LOCUS       BGC0000286             19462 bp    DNA     linear   BCT 08-FEB-2006
DEFINITION  Streptomyces sp. KO-3988 viguiepinol
            [3-hydroxypimara-9(11),15-diene] biosynthetic gene cluster and
            mevalonate gene cluster, complete cds.
ACCESSION   BGC0000286
VERSION     BGC0000286
KEYWORDS    .
SOURCE      Streptomyces sp. KO-3988
  ORGANISM  Streptomyces sp. KO-3988
            Bacteria; Actinobacteria; Streptomycetales; Streptomycetaceae;
            Streptomyces.
COMMENT     ##antiSMASH-Data-START##
            Version      :: 6.2.0-924c3663(changed)
            Run date     :: 2022-11-07 18:04:49
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 19462
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     source          1..19462
                     /db_xref="taxon:285219"
                     /mol_type="genomic DNA"
                     /organism="Streptomyces sp. KO-3988"
                     /strain="KO-3988"
     protocluster    1..19462
                     /aStool="rule-based-clusters"
                     /category="PKS"
                     /contig_edge="True"
                     /core_location="[10703:11879]"
                     /cutoff="20000"
                     /detection_rule="(Chal_sti_synt_C or Chal_sti_synt_N)"
                     /neighbourhood="20000"
                     /product="T3PKS"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10704..11879
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(Chal_sti_synt_C or Chal_sti_synt_N)"
                     /neighbourhood="20000"
                     /product="T3PKS"
                     /protocluster_number="1"
     cand_cluster    1..19462
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(Chal_sti_synt_C or Chal_sti_synt_N)"
                     /kind="single"
                     /product="T3PKS"
                     /protoclusters="1"
                     /tool="antismash"
     subregion       1..19462
                     /aStool="externally annotated by: MIBiG"
                     /contig_edge="True"
                     /label="BGC0000286"
                     /subregion_number="1"
                     /tool="antismash"
     region          1..19462
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="T3PKS"
                     /region_number="1"
                     /rules="(Chal_sti_synt_C or Chal_sti_synt_N)"
                     /subregion_numbers="1"
                     /tool="antismash"
     gene            18..1406
                     /gene="p450"
     CDS             18..1406
                     /codon_start=1
                     /gene="p450"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) p450"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1034:cytochrome P450 (Score: 402.5; E-value:
                     4.1e-122)"
                     /gene_kind="biosynthetic-additional"
                     /product="putative P450"
                     /protein_id="BAD86796.1"
                     /sec_met_domain="p450 (E-value: 3.8e-72, bitscore: 233.4,
                     seeds: 50, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPELPAIRRAPRRLPLAGHAVPLLVQPLEFLKSLPALGDMVRVRM
                     GPDDAYVPCDPALFRQILKDTRLYDKGGLFYDRGREAVGNGLVTSRWADHRRQRPLMQP
                     SFDHRHIGHYAELMADETEALMRSWRSGEVVDVDKAMARLTLRITTRSLFSVPADHTLV
                     AQVEKWLPILMDGFFRRMFVPARVLSLVPGKMNRQYPPPIAEMRKLTEEIIDEVRRKKD
                     EDPGLLAGLMNARDETTGAPLGTQEIFDQVLILLIAGSETTATALAFTFHLLGAHPEIG
                     ARLREEVDGALGGRTPRFEDLSGLTFTRQVLMESLRLYPPAWMFTRSTTTACELGGHAF
                     PEGTTFLLSPYILQHDPELFPRPERFDPDRWRPGAMSDVARRSVLPFGAGGRKCIGDQF
                     ALNEAMLAVAAIAGRWNLTPVGDRPIRPIARATLKTGPLPMRLQERPHEPVRNATTTDL
                     RDQR"
     gene            1414..2949
                     /gene="ent-cdps"
     CDS             1414..2949
                     /codon_start=1
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /gene="ent-cdps"
                     /product="ent-copalyl diphosphate synthase"
                     /protein_id="BAD86797.1"
                     /transl_table=11
                     /translation="MNVTSFAALRAAAQDIVDEMIADPYGLTSPSVYETARMVVSAPWL
                     EGHRQRVEFLLAQQHEDGTWGGPAAYGLLPTLSAVDALLSVAGTQDARRVAGAVESGLA
                     ALAGRFPRNVELPDTIAVELLVPWLIEQVDQRLSRMDDRGDLPGRLDLQADTGTLSGIR
                     ELLRQNTGIPEKTWHSLEALGAPAVRSGTVTPMGGAVGASPAATSAWLGDPPHTDAAKA
                     CLAYLHQTQARHGGPVSGITSISYFELAWVVTALSGSGLDVDIPAQVPDILRTALGANG
                     LSAGPGLPADSDDTSAALHALDLLGKPESVDCLWEYDTGLYFTCFPKERTPSTSTNAHI
                     LVALADRRGQGDTRYDHAAERVGGWLVEQQQPDGRWMDKWHASPYYATACGAAAMARLD
                     GPRTSAALDDAIRWVLDTQHADGSWGRWEGTGEETAYALQVLNHRAAPDRPALEAIRAG
                     RAFLSGHVEDDRRNPPLWHDKDLYTPVRVIRAEILGTLAATQRLAEAEKEARA"
     CDS             2990..3877
                     /codon_start=1
                     /product="hypothetical protein"
                     /protein_id="BAD86798.1"
                     /transl_table=11
                     /translation="MRARHRVALKVLADLRSWAAEYPQVLEATPIEALAISTAAISPWR
                     GANELRLSAPDVRCGPTPLDDHVEQNVRSLDELDDLFGRCEAIVRGGDRDDGHPLLASL
                     SGWQSALERAPHYPKLAGLWGDRFAEALRGERYDWTAGLARDRGEGPSDPQEYLTYAAS
                     SNAWITHFPRWATSDRDDLLDGLPVLDNALEAIEVAVRLSNDLATFERERAEPGQNNIL
                     MYDTSPDWVHDELDRHSRKAQEQLDPLATAGFPPAVELLRLLDWSVTFYSGADFRGWGS
                     DRDLTGPSGLPSDM"
     gene            4011..5177
                     /gene="ggdps"
     CDS             4011..5177
                     /codon_start=1
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /gene="ggdps"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1182:Polyprenyl synthetase (Score: 285; E-value:
                     1e-86)"
                     /gene_kind="biosynthetic-additional"
                     /product="geranylgeranyl diphosphate synthase"
                     /protein_id="BAD86799.1"
                     /transl_table=11
                     /translation="MLPFGGSPPVPRPHGRGPHGLHEQEQRHMSPTTSLHELGSGVLDS
                     VHLRGLIDERLNAFLDAKSGRDTDVHLVSLIEHLRDFLAAGGKRIRPLLCMVGWHAAGG
                     YGETEPIIGAAASLELFHAFTLIHDDVMDASDTRRGRPTLHRTLETGANGTTAERFGTN
                     SAILLGDLVMVWSDELLYSSGLDQQQLVAVRPLLDAMRTEVMIGQYRDLLSTGQPTADV
                     ERSLAVIRYKTAKYTVERPLHIGAALAGADQSLLDVCTAYALPIGEAFQLRDDLLGVFG
                     DPSKTGKSTLDDLREGKATALMAHALHTAGTEQARVLRSLVGDPDLDEAGAETVRGVLR
                     ATGAADKVEQMITDRVQRARRVLDEAPFPDEVKKTLDTFVTTTTLRTT"
     gene            5355..6386
                     /gene="mevk"
     CDS             5355..6386
                     /codon_start=1
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /gene="mevk"
                     /product="mevalonate kinase"
                     /protein_id="BAD86800.1"
                     /transl_table=11
                     /translation="MKFRQGELNTSTPPASVAGTAESRRARSVGTGRAHAKSILLGEHA
                     VVYGAPALALPVPQLSITASAGFSNRGGEAAGVSFTMTGSAWKQVGTQASEGLRRLTTD
                     FRASMGIDEGPHLDVIIDGSIPLGRGLGSSAACARAVVLALADLCGREVSQRTTFDLVQ
                     TAENVMHGKASGVDAVTVGASAPLLFQAGEARTLRVGCDALFVIADSGAVGSTKEAVDK
                     LRERFRLHAGTQERFVRRASELTGEPVAALAAGQPEELGSLLTEYHGLLREAGLSTDRI
                     EAMVSAALAADSLGAKITGGGLGGCVLALTQPEQAREVTRRLHEAGAVQTWIVPLRRLV
                     THV"
     gene            6379..7431
                     /gene="mdpd"
     CDS             6379..7431
                     /codon_start=1
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /gene="mdpd"
                     /product="mevalonate diphosphate decarboxylase"
                     /protein_id="BAD86801.1"
                     /transl_table=11
                     /translation="MSEQQIAVLRPREQPGANGVTAVAQPNIALIKYWGKRDEHLFLPW
                     TSSLSMTLDIFPTTTRVHLDAEATDDEVTFNGAPAAGEERRRITGFLDLVRQRAGLTHR
                     AVVDTRNTVPTGAGLASSAGGFAALAVAAATAYGLDLDDTGLSRLARRGSGSASRSIFG
                     GFAVWNAGTPTAPPAEADLSSYAEPVPVGDLDPALVIAVVNAGPKDVSSRAAMRRTVET
                     SPLFEPWAASSRDDLTEMRQALLRADLDAVGEIAERNSLGMHATMLSARPAVRYLSPAS
                     LTVLDSVLRLRRDGISAYATMDAGPNVKVLCRRADADLVAEAVRAAAAGGTVHIAGTGQ
                     GARLIDEDGR"
     gene            7428..8555
                     /gene="pmk"
     CDS             7428..8555
                     /codon_start=1
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /gene="pmk"
                     /product="phosphomevalonate kinase"
                     /protein_id="BAD86802.1"
                     /transl_table=11
                     /translation="MTSGRTVVRSAPGKLFVAGEYAVVEPGTPAVLVAVDREITVMATL
                     SDAADIVISSDLVPRAVTWRWRDGRLHAPGTKNGDADGDGARGALAHVVSAVETVRRLL
                     VERGLPLPGLEISISSRLHDNGRKYGLGSSGAVTVATIDALTSLCGLDLSLDARYRLAV
                     ISSAGIDPKGSGGDLAASTWGGWIAYQAPDRAFVLDLTRRHGIEEALRTPWPGLAVRRL
                     PAPRGLTLEVGWTGSPASTTSLVSGLHRRTWRGTASHRAFLETSTDFVRASITALEAGD
                     DQSLLRQIRRARQELACLDDEVGLGIFTPELTALCAVAETVGGAAKPSGAGGGDCGIAL
                     LDAEATHDISHVRQGWAAAGVLALPVRPAPKGIEE"
     gene            8552..9643
                     /gene="fni"
     CDS             8552..9643
                     /codon_start=1
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /gene="fni"
                     /product="isopentenyl diphosphate isomerase"
                     /protein_id="BAD86803.1"
                     /transl_table=11
                     /translation="MSVQRKDDHVRLAIEQQDTRSGINQFDEVSFVHHALAGIDRPQVS
                     LGTSFAGISWQVPLYINAMTGGTARTGVINRGLATAARETGVPLASGSVHAYLKDPTCA
                     DTFRVLRRENPHGFVMANVNATASVADTRRAIDLLEADALQIHVNTAQETAMPEGDRSF
                     GSWVSQIEKITAAVDLPVIVKEVGNGLSRETVLTLRQLGVSVADLGGRGGTDFARIENG
                     RRPLGDYAFLHDWGQSTAACLLDAQGAGLPVLASGGVRHPLDAARALALGASGVGASGV
                     FPRTLLDGGVEALIAQITNWLDQLAALQTMLGARTPAELASKDLLIHGTLRTFCADRDI
                     DAGRLARRTRSADALHDSTGRAR"
     gene            9640..10701
                     /gene="hmgr"
     CDS             9640..10701
                     /codon_start=1
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /gene="hmgr"
                     /note="A 1.8 kb-BamHI fragment containing this CDS is
                     deposited in Acc# AB015627"
                     /product="3-hydroxy-3-methylglutaryl-CoA reductase"
                     /protein_id="BAD86804.1"
                     /transl_table=11
                     /translation="MTDTHAIARVPMKWVGPLRISGNVATTETHVPLATYETPLWPSVG
                     RGAKVSMLSERGIAATLVDERMTRSVLVEATDAQTAYTAARAIEARIEELRAVVRTCSR
                     FAELLQVRHEIAGNLLFVRFEFSTGDASGHNMATLASDALLAHLLQTIPGISYGSISGN
                     YCTDKKATAINGILGRGKNVVTELVVEREVVERVLHTTAAKIVELNIRKNLLGTLLAGG
                     IRSANAHYANMLLGFYLATGQDAANIVEGSQGVTLAEDRDGDLYFSCNLPNLIVGTVGN
                     GKGLEFVETNLNRLGCREDRAPGENARRLAVIAAATVLCGELSLLAAQTNPGELMRAHV
                     ELERDNTTAEVGV"
     gene            10704..11879
                     /gene="hmgs"
     CDS             10704..11879
                     /codon_start=1
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /gene="hmgs"
                     /gene_functions="biosynthetic (rule-based-clusters) T3PKS:
                     Chal_sti_synt_N"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1043:hydroxymethylglutaryl-CoA synthase (Score: 472;
                     E-value: 2.3e-143)"
                     /gene_kind="biosynthetic"
                     /product="3-hydroxy-3-methylglutaryl-CoA synthase"
                     /protein_id="BAD86805.1"
                     /sec_met_domain="Chal_sti_synt_N (E-value: 1.6e-10,
                     bitscore: 30.8, seeds: 21, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSHESFFGIHDLSFATTEYVLSHEALAEYNGTEIGKYHIGIGQRS
                     MSVPAADEDIVTLGAAAAAPIIARHGSGRIRTVVLATESSIDQAKSAGVYVHSLLGLPS
                     ACRVVELKQACYGATAALQFAIGLVRRDPDQQVLVIASDVSKYELDSPGEATQGAAAVA
                     MLVSADPALVRIENPSGLFTADVMDFWRPNYLTTALVDGQESVQAYLQAVASSWKDYGE
                     QGGRALDEFAAFCYHQPFTKMAYKAHHHLLNYAGQETDKADIEHAIGRTVAYNATIGNS
                     YTASVYLALAALLDQADDLTDRPIGFLSYGSGSVAEFFAGTAAPGYREHLRTEANLEAI
                     ARRKPVDHARYRELHERSFPADGGEHLTPQQTTGPFRLAGLSGHKRIYQAR"
     misc_feature    10941..10943
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     CDS             11991..12971
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) fabH"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1084:3-oxoacyl-(acyl carrier protein) synthase III
                     (Score: 361.6; E-value: 5.4e-110)"
                     /gene_kind="biosynthetic-additional"
                     /product="putative 3-oxoacyl-[acyl-carrier-protein]"
                     /protein_id="BAD86806.1"
                     /sec_met_domain="fabH (E-value: 1e-93, bitscore: 303.9,
                     seeds: 7, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTDLRILGTGAYVPERIASNDEVAAAAGVDDAWITAKTGIRERRW
                     AADDQATSDLATAAGRAALRSAGITAEDLSVIVVATSTPDRPQPPTAAYVQQRLGASDA
                     AAFDVNAVCSGMVFALAAAEGVLTRTGGHALVIGADLYSRILNRADRRTVILFGDGAGA
                     VILGSSVDHGPRIRHLALHSFGELSGLIEVPAGGSRMPVDQTVLDAGLQYFAMDGRGVR
                     NFVCDHLPQLVKGFLHKCGVVPDDIDHFVPHQANGTMLDSLFADLELPRATMHRTLTHY
                     ANTGAASIPITLDAAARAGAFNPGDLILMAGFGGGMSAGFALVEW"
     CDS             13090..13872
                     /codon_start=1
                     /product="hypothetical protein"
                     /protein_id="BAD86807.1"
                     /transl_table=11
                     /translation="MTTPNRFPLASGGRGGGEVRRRLGARDPAQRPVVPRPGAPVPNRF
                     RRQGEQVTDRPFYVLLGPDYAGKSSVMTELSAAMPGWQTLSTDDDLVAGEHRLISQLRR
                     NVVRDVLPGLGPTYSADFLASLLGTAVVHLRDQLERQEPDVPVLMDSYYYKILAKCRLA
                     GLEMHPLYTWWRSFPLPRGVIYLDVSPETAWRRSGRGAQLNPLEHFGDRPEWFGFESYQ
                     KNLGKLLLEETGQLPVTVVEERSGTAATAAAVREVLAA"
     CDS             13869..15569
                     /codon_start=1
                     /product="hypothetical protein"
                     /protein_id="BAD86808.1"
                     /transl_table=11
                     /translation="MSETQGWGTPGHADRYRERVFAERAQLSAGLDDLPQQQQRVLDDL
                     LEFNGGTEFGRRHGFAAIRTLKDYRAAVPIQDYAAHAPLIERMAAGEPNLLTQDAPVVY
                     FTSSGSTGDHKKIPITRRFMKTVFFPFYYAAWAPLIESLPELMERPDAVLNLKHDPLAV
                     PPVTTSGRPHVGASQVDFGAAFGEPLSAELGTAAPWATLPVDVAPDDHLEKMYLRLRLA
                     VQSDVRGLIGINPAMIAAVPYQLELWWQRIVKEVRDGTLGGVPYGDPDPERAARLEFLA
                     GHFGRPSPAHVWPQVRALFGWSTGVASLYMPGLRERFGAGVRVLPAPVAASEGPVAVPL
                     DRHPAAGSLVPSAAVYEFVDADEDLGPGAETLVAEELEPNRDYHVLFSHVGGLYRYAVG
                     DVVRVVDRVRGVPRVLYAGRATRSDAAGERLREAQVVRALGEALASTGLALRNVACRVE
                     ETAGEAPRYVFAVAPEAPWLESETVRFARLLDAALAAESPGYARALRERRLGAATLRLL
                     HIDAFQREWHARVADGVRPTQVKDRLFRQDESQWRRLIAASDALRGEGT"
     CDS             15566..16432
                     /codon_start=1
                     /product="hypothetical protein"
                     /protein_id="BAD86809.1"
                     /transl_table=11
                     /translation="MMHVQDPVDPVETTALLTAALRAAESGREDRLYKDPYAAALVGDA
                     GPRLLAEIRAATFPPDGPRSVPSTPDYNAIRTRFFDDLLQEAVQDQGMTQLVVAPAGMD
                     SRAYRLPWPRHLRYFEVDRPSVLAFKEERLRGVDPRVDHVTVAVDLTADDWEDRLRASG
                     YDPSTPSTWLLEGLLYYIPEKDTERMLERVGAFCAPGSRIAADLVNSAALTLPHMRPLL
                     DVFSGWGCPWLFGSDEPEALFERYGFDVAAVQPGEPGAHFGRWPDPVPDRAVKDVRRVF
                     FVHGQRR"
     CDS             16429..17862
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1246:monooxygenase FAD-binding (Score: 343.8; E-value:
                     2.4e-104)"
                     /gene_kind="biosynthetic-additional"
                     /product="hypothetical protein"
                     /protein_id="BAD86810.1"
                     /transl_table=11
                     /translation="MTGPVVVGGSVAGLAAGLALALRGLPVRVLEQAPVPPEGPPGKAA
                     ELWKRPTVAQNGHSHVLTSLGVRVLRAHVPQVLDAALEAGARMLDLMRALPVRADDGIR
                     RQGDEELVALAVRRPVFELVLRQALRSLPNVTISHDVKVIGLRTTPSGNRVTGLVTGDG
                     EDIPTHTVVDATGRRSASRSWLTAAGFPPEAARTAPTRVRAFTRFYRLRSPGTLPGPLN
                     RGNAAGGIWDHYAAVAHLADNDTYALTVGVPTADPATTGLRHPAAFTAVARLSPYLAAW
                     ADPAVGEPISAVRAITLPPNTLHCAPDAGAGPIAGLYPVGDAACVTDPLFGRGMSLALR
                     HAFLLADFLADEPAVEEQGERAARIADGVYRSWYEQSVREDAARTALWQARVTGCPPPT
                     VSESGRAALSEVARAAAADGTVWRGLTRVLMGLETVEDVFDDEAFRRRVRTAPEPAAAA
                     PRPLTREELVAAVRDEVRA"
     misc_feature    16492..16494
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
ORIGIN
        1 ctgcagtact tggagccatg ccggagctac ctgccatcag acgagcccct cgacgcctgc
       61 ctctcgcagg ccatgccgta cctctgctcg tacagccgtt ggaattcctg aagtcactcc
      121 cggcactcgg cgacatggtc agagtcagga tgggtcccga cgacgcctat gtgccctgcg
      181 atcccgccct gttccggcag atactcaagg acacccggct ctacgacaag ggcggcctgt
      241 tctacgatcg gggccgcgag gccgtgggaa acggcctggt caccagtcgc tgggccgatc
      301 accgtcggca acgcccgctg atgcagccgt cgttcgacca ccggcacatc ggccactacg
      361 ccgaactgat ggcggacgag acggaagccc tgatgcgctc ctggcgatcg ggcgaggtcg
      421 tcgacgtcga caaggcgatg gcaagactca ctcttcgcat cacgaccaga tcccttttct
      481 cggtgcccgc ggaccacacg ttggtggccc aggtggagaa atggctgccg attctcatgg
      541 acggcttctt ccggcgcatg ttcgtgccgg cgcgggttct ctcgctcgtt cccgggaaga
      601 tgaaccggca ataccccccc cccatcgcgg agatgcgcaa gctcaccgaa gagatcatcg
      661 acgaggtgcg gcgcaagaag gacgaggacc ccggcctgct cgcgggcctg atgaacgcgc
      721 gcgacgagac caccggggcc ccgctcggaa cgcaggagat cttcgaccag gtcctgatcc
      781 tgctgatcgc cgggtcggag accaccgcga cggcgctggc gttcaccttc catctgctcg
      841 gcgcgcaccc cgagatcggc gcccgcctgc gggaggaggt cgacggcgcg ctcggcggcc
      901 ggacgccccg cttcgaggat ctctccgggc tgacgttcac gaggcaggtg ctcatggaga
      961 gccttcgcct ctatccgccg gcgtggatgt tcacccggtc caccaccacg gcctgcgaac
     1021 tcggcgggca cgcgttcccc gagggaacca ccttcctgct cagcccctac atcctgcagc
     1081 acgacccgga gttgttcccc cggccggaga ggttcgatcc ggatcgctgg cggcccggcg
     1141 cgatgagcga cgtcgcacgc cggtcggtgc tgcccttcgg cgcgggcggc aggaagtgca
     1201 tcggcgacca gttcgcgctc aacgaggcga tgttggccgt cgcggcgatc gccggccgct
     1261 ggaacctgac ccccgtcggt gaccggccga tacggcccat cgcccgcgcc acgctcaaga
     1321 cgggccctct tccgatgagg ctccaggagc gcccgcacga accggtgcgg aatgcgacga
     1381 ccaccgatct ccgagaccag aggtagccgg atcatgaacg tgacctcctt cgcagccctg
     1441 cgtgccgcgg ctcaggacat cgtcgacgag atgatcgccg acccctacgg actcacctcg
     1501 ccgtcggtgt acgagaccgc gcggatggtg gtgtccgccc cctggctgga gggccatcgg
     1561 cagcgcgtgg agttcctgct ggcccagcag cacgaggacg gaacgtgggg cgggcctgcg
     1621 gcctacgggc tgctgcccac gctcagcgcc gtcgacgccc tgctgtccgt cgccggtacg
     1681 caggacgcgc ggcgggtcgc cggggccgtg gagtcggggc tggccgcgct ggccgggcgg
     1741 ttcccccgga acgtcgaact gccggacacc atcgccgtgg agctgctggt gccctggctg
     1801 atcgagcagg tcgatcagcg gctctcccgg atggacgacc ggggcgatct gcccggccgt
     1861 ctggacctcc aagccgatac gggaacgctg agcgggatcc gcgagctgct gcgtcagaac
     1921 accggcatac cggagaagac ctggcactcg ctggaggccc tcggcgcccc ggccgtgcgg
     1981 tccggcacgg tgacgccgat gggcggggcg gtgggagcct cccccgccgc cacctccgcc
     2041 tggctgggcg atccgcctca tacggacgcc gcgaaggcgt gcctggcgta tctgcatcag
     2101 acccaggcac gtcatggcgg cccggtctcg ggcatcacct cgatcagcta cttcgaactg
     2161 gcctgggtgg tgacggcgtt gtccggctcc ggcctggacg tggacatccc cgcccaggtc
     2221 ccggacattc tgcggaccgc gctgggggcg aacggactgt ccgccggccc gggtctcccg
     2281 gccgactccg acgacacgtc ggccgccctg cacgccctcg atctcctcgg gaagccggaa
     2341 tcggtcgatt gcctgtggga gtacgacacc ggcctgtact tcacctgctt cccgaaggaa
     2401 cgcaccccct ccacctcgac gaacgcacac atcctcgtcg ccctggcgga tcgccgcgga
     2461 cagggcgaca cgcgctacga ccacgccgcc gagcgggtgg gaggctggct cgtcgagcag
     2521 cagcagccgg acggccggtg gatggacaag tggcacgcct ctccgtacta cgcgaccgcc
     2581 tgcggcgctg ccgccatggc ccgcctggac gggccgcgca cgtccgccgc cctggacgac
     2641 gccatccgct gggtgctcga cacccagcac gccgacgggt catggggacg ctgggagggc
     2701 accggcgagg agaccgccta tgcccttcag gtgctgaacc atcgcgccgc ccccgaccga
     2761 ccggccctcg aagcgatccg ggcgggcagg gcgttcctgt caggccatgt cgaggacgat
     2821 cgtaggaatc ctccgctgtg gcacgacaag gacctgtaca caccggtccg ggtcatccgc
     2881 gccgagatcc tcggcaccct ggccgcgacg cagcgcctgg ccgaggccga gaaggaggca
     2941 cgagcgtgac ccggcccctt ggcgacctct ccctcccctc cgcggcgcaa tgcgtgcccg
     3001 tcaccgtgtg gcgctgaagg tcctggccga tctgcggtcc tgggcggcgg aatacccgca
     3061 ggtcctcgag gccacgccga tcgaagccct ggcgatctcc accgcggcga tcagcccgtg
     3121 gcgcggagcg aacgagctcc ggctgtcggc cccggatgta cgctgtgggc ctacgcccct
     3181 ggacgaccac gtcgagcaga acgtccggag cctcgacgaa ctcgacgacc tgttcggtcg
     3241 ctgcgaggcc atcgtccggg gcggcgaccg ggacgacggc catcccctgc tggcctccct
     3301 gtccggctgg cagtccgctt tggagcgggc tccccactac ccgaaactgg ccggcctgtg
     3361 gggcgaccga ttcgccgagg ccctgcgcgg cgagcggtac gactggaccg cgggtctggc
     3421 cagggaccgc ggcgagggcc cttccgatcc gcaggagtac ctgacgtacg ccgccagctc
     3481 caatgcgtgg ataacccact tcccgcgctg ggcgaccagc gaccgggacg atctcctcga
     3541 tggcctgccg gtcctggaca acgccctgga ggcgatcgaa gtcgccgtgc gcctctccaa
     3601 cgacctggcc accttcgagc gggagcgggc cgagcccggt cagaacaaca tcctgatgta
     3661 cgacacctca cccgactggg tgcacgacga actcgaccgg cattcccgca aggcgcagga
     3721 gcagctcgac ccgctggcga cggccgggtt cccacccgct gtcgagctgc tccgcctgct
     3781 cgattggtcg gtcaccttct acagcggcgc cgacttccgg ggatggggat ccgaccgcga
     3841 tctcaccggg ccgtccggcc tgccctccga catgtgaacc cacgtgtacg gagggccggc
     3901 cacgcggcgc ggtccgaaca gcccgtcacc gctcgcccct ccatcggcga ctcgcacccg
     3961 cggcgcggcc cggcgactgc cgggaccctc ctccgcccgg ccggaaagtg atgcttccct
     4021 tcggcggttc ccctcccgtg ccacgccctc acggacgcgg cccacacggt cttcacgaac
     4081 aggagcaacg acacatgagc cccaccacca gccttcacga gctgggatcc ggcgtcctgg
     4141 actcggttca tctgcgcggc ctgatcgacg aaagactgaa cgccttcctc gacgccaagt
     4201 ccggcaggga cacggatgtc cacctggtct cgctcatcga gcacctgcgt gacttcctgg
     4261 ccgcgggcgg caagcgcata cggccgctct tgtgcatggt gggctggcac gcggcgggag
     4321 gatacggcga aacggagccc atcatcggcg cggcggcctc gctcgaactc ttccacgcct
     4381 tcaccctcat ccatgacgac gtgatggacg cctccgacac ccggcgcggc cgtccgaccc
     4441 ttcaccgcac gctggagacg ggtgcgaacg gcacgaccgc cgagcggttc ggcaccaaca
     4501 gcgcgatcct gctcggcgac ctggtcatgg tgtggtcgga cgagctgctg tactcaagcg
     4561 gcctcgacca gcagcaactg gtcgccgttc gaccgctgtt ggacgccatg cgtaccgagg
     4621 tgatgatcgg tcagtaccgg gatctgctgt ccaccgggca gcccaccgcg gacgtcgaac
     4681 ggtcgctggc agtgatccgc tacaaaacgg ccaagtacac cgtggagcgg ccgctgcaca
     4741 tcggcgcggc ccttgccgga gcggaccagt ccctgctgga cgtctgcacc gcctacgctc
     4801 ttccgatcgg agaggccttc caactgcgcg acgacctgct cggcgtcttc ggcgacccgt
     4861 ccaagaccgg caagtcgacc ctggacgacc tgcgggaggg caaagcgaca gccctgatgg
     4921 cgcacgccct ccacaccgcc ggcaccgagc aggcgcgggt gctgaggtcc ctggtcggcg
     4981 acccggacct ggacgaagca ggcgccgaga cggtccgcgg ggttctacgg gccacgggcg
     5041 ccgccgacaa ggtggagcag atgatcaccg atcgggtgca gcgtgcccgg cgggtcctgg
     5101 acgaggcccc gttcccggac gaggtcaaga agaccctcga caccttcgtc accaccacca
     5161 cgctcaggac cacctgagca ccacgtcggc gcgggtcacc accgtctcga cgccctgact
     5221 cgccccgagc gatgacggcg ccggcggccg cgaccaccgg ccacggtggt ccctgggtgg
     5281 ccggagcatg acgcgacacg cggtcgaacg ggcttacttc attccttcct agaagtctgg
     5341 atgacgcgat ctcaatgaaa tttcgacaag gggagctgaa tacgtcgact ccaccggcct
     5401 cggtggcggg gacagcggaa agccgccgcg cccgctcggt cggcaccggc cgcgcccacg
     5461 ccaagtccat tttgctgggg gagcacgcgg tcgtctacgg agccccggcg ctcgccctgc
     5521 ccgttccgca gctgtcgatc accgccagcg ccgggttctc caaccgcggt ggggaagcgg
     5581 ccggcgtgtc cttcacgatg accggatccg cctggaagca ggtcggaacg caggcatccg
     5641 aggggctgcg ccggctgacc accgacttca gggcgtccat gggcatcgac gagggaccgc
     5701 acctcgatgt gatcatcgac ggttccatcc cgctcggcag gggacttggc tccagcgcgg
     5761 cctgcgcccg tgccgtcgtc ctcgccctgg ccgacctctg cggccgcgag gtctcgcagc
     5821 ggacgacgtt cgacctggtg cagaccgccg agaacgtgat gcacggcaag gccagcggcg
     5881 tcgacgccgt caccgtgggc gcgagcgccc cgttgctgtt ccaggcgggc gaggcccgca
     5941 cgctgcgtgt cggctgcgac gcgctgttcg tcatcgcgga cagcggcgcc gtcggcagca
     6001 ccaaagaagc ggtcgacaaa ctgcgggaga ggttccggct ccacgccgga acacaggaga
     6061 ggttcgtacg ccgggcgtcg gaactgactg gcgaaccggt ggccgccctc gccgccggcc
     6121 agccggagga gctcggctcc ctgctgacgg agtaccacgg actgctccgc gaggccgggc
     6181 tgagcaccga ccggatcgag gcgatggtga gtgccgcgct cgccgcagac agcctcggcg
     6241 ccaagatcac cggcggcgga ctgggcggct gcgtccttgc gctgacccag cccgagcagg
     6301 cgagagaggt cacccggcgg ctgcacgaag cgggggccgt gcagacgtgg atcgtcccgc
     6361 tgaggaggct cgtcactcat gtctgagcaa cagatcgccg tcctccgccc gcgggaacag
     6421 ccgggtgcga acggggtcac cgccgtcgcg cagccgaaca tcgcgctgat caagtactgg
     6481 gggaagcggg acgagcacct cttcctcccg tggaccagca gcctgtcgat gaccctggac
     6541 atcttcccca cgaccacccg tgtccacctc gacgccgagg ccacggacga cgaagtgacc
     6601 ttcaacggcg cacccgcggc gggcgaagaa cggcggcgca tcaccggatt cctcgatctg
     6661 gtgcgccaac gggccgggct cacgcaccgg gccgtcgtcg acacccgcaa caccgtgccc
     6721 accggggcgg gcctcgcgtc ctccgccggc gggttcgccg cactcgccgt cgccgccgcc
     6781 accgcgtacg gactggacct cgacgacacc ggtctctccc gcctggcccg ccgcggctcc
     6841 ggctcggcct cgcggtcgat cttcggcggc ttcgccgtct ggaacgccgg cactcccacg
     6901 gcgccccctg cggaggccga cctcagctcc tacgcggagc cggtacctgt gggcgacctc
     6961 gaccccgcac tggtcatcgc ggtggtgaac gccggtccca aggacgtgtc cagccgcgcg
     7021 gccatgcgcc gaaccgtcga gacctcaccc ctgttcgagc cctgggccgc gtcgagccgg
     7081 gacgacctga ccgagatgag acaggcgctc ctgcgcgccg acctcgacgc ggtgggcgag
     7141 atcgccgagc gcaactcgct cggcatgcac gcgaccatgc tgagcgcgcg ccctgcggtg
     7201 cgctacctct cgcccgcctc gctcaccgtc ctcgacagcg tgctgcggct tcggcgcgac
     7261 ggcatatcgg cctacgcgac catggacgcc ggaccgaatg tcaaggtgct ctgccgtcgt
     7321 gcggacgccg acctggtcgc cgaggccgtg cgcgccgccg ccgcgggcgg caccgtgcac
     7381 atcgccggga cggggcaggg cgcccgcctg atcgacgagg acggacgatg acctccgggc
     7441 gaacggtcgt ccgcagcgcg cccggcaagc tgttcgtcgc gggcgagtac gcggtggtgg
     7501 agcccggtac cccggccgtc ctggtggccg tggaccggga gatcaccgtc atggcgaccc
     7561 tctccgacgc ggccgacatc gtgatctcct ccgatctcgt cccccgagcg gtgacgtggc
     7621 gatggcgcga cgggcggctc cacgcgcccg gcacgaagaa cggggacgcc gacggggacg
     7681 gcgcacgcgg cgcactggcg cacgtggtgt cagcggtcga gaccgtgcgg agactcctgg
     7741 tcgaacgcgg cctgcccctg cccgggctgg agatctcgat cagcagccgg ctgcacgaca
     7801 acggccgcaa gtacggcctg gggtcgagcg gtgcggtgac cgtggccacg atcgacgccc
     7861 tcacgtccct gtgcggactg gacctctcgc tcgacgcccg gtaccgcctg gccgtgatct
     7921 cctcggccgg gatcgacccc aagggctccg gcggtgacct cgccgccagt acatggggcg
     7981 gctggatcgc gtaccaggca cccgaccggg ccttcgtgct cgacctcacc cgccgccacg
     8041 gcatcgagga agcgctccgc accccctggc cgggcctcgc ggtccgaagg cttccggccc
     8101 cccgcggcct caccctcgaa gtcggctgga ccggcagccc ggcctcgacc acctcgctcg
     8161 tgtccggtct gcaccgccgg acctggcgcg gcaccgcctc gcaccgcgcg ttcctggaga
     8221 cctccaccga cttcgtacgc gcctcgatca ccgccctcga ggccggcgac gaccagagcc
     8281 tgctgcgcca gatccgccgt gcccggcagg agctggcctg cctcgacgac gaagtcgggc
     8341 tcggcatctt cacacccgag ctgacggccc tgtgcgcggt cgccgaaacc gtcggcggcg
     8401 ccgccaagcc gtcgggcgcg ggcggcggcg actgcggcat cgctctgctc gacgccgaag
     8461 ccacgcacga catctcgcac gtacggcaag ggtgggccgc ggccggtgtg ctggccctgc
     8521 ccgtccggcc cgccccgaaa gggatcgagg aatgagcgtt cagcgcaagg acgaccacgt
     8581 ccggctcgcc atcgagcagc aggacacccg cagcgggatc aatcagttcg acgaggtgtc
     8641 cttcgtacac cacgccctgg ccggcatcga ccggccgcag gtgtccctgg gcacgagctt
     8701 cgccgggatc tcctggcagg tgccgctcta catcaacgcg atgaccggcg gcaccgccag
     8761 gaccggcgtc atcaaccggg gcctggcgac ggccgcccgc gagaccgggg tacccctcgc
     8821 gtcgggctcc gtgcacgcct acctcaagga cccgacgtgc gccgacacct tccgcgtcct
     8881 gcgccgggag aacccccacg ggttcgtcat ggccaacgtg aacgcgacgg catcggtcgc
     8941 cgacacccgg cgtgccatcg atctgctgga ggccgacgcc ctgcagatcc acgtcaatac
     9001 ggcgcaggag acggcgatgc cggagggcga ccggtccttc ggatcctggg tctcgcagat
     9061 cgagaagatc acggcggccg tcgacctgcc cgtgatcgtc aaggaggtcg gcaacggcct
     9121 gagccgcgag accgtcctga cgctgcgaca gctgggtgtc agcgtggcgg acctcggcgg
     9181 ccggggcggc accgacttcg cccgcatcga gaacggccgg cgcccgctcg gcgactacgc
     9241 cttcctccac gactggggcc agtccaccgc cgcctgcctc ctggacgcgc agggcgccgg
     9301 tctccccgtg ctcgcctccg gcggcgtccg ccatcccctc gacgccgccc gagccctggc
     9361 cttgggcgcc tccggcgtcg gggcctccgg agtgttcccg cgcaccctgc tcgacggcgg
     9421 tgtcgaggcg ctgatcgcac agatcacgaa ctggctggac cagctcgcgg ccctgcagac
     9481 catgctcggc gcacgcaccc ccgccgagct cgcgagcaag gacctgctga tccacggcac
     9541 cctgcgaacc ttctgcgccg accgggacat cgacgcgggg cgactcgccc ggcgtacccg
     9601 atcggccgac gccctccacg attcgacggg aagagcacga tgaccgacac gcacgccatt
     9661 gccagggtcc ccatgaagtg ggtcggcccc cttcgcatct ccgggaacgt cgccaccacc
     9721 gaaacgcacg tcccgctcgc cacctacgag acgccgctgt ggccctccgt gggccggggc
     9781 gcgaaggtgt ccatgctgtc cgagcggggc atcgccgcga ccctcgtcga cgagcggatg
     9841 acccgctcgg tgctggtcga ggcgaccgac gcccagaccg cgtacacggc cgcccgcgcc
     9901 atcgaggcgc ggatcgagga actgcgcgcc gtggtccgca cctgcagccg gttcgccgag
     9961 ctgctccagg tccggcacga gatcgcgggc aacctgctgt tcgtccgctt cgagttcagc
    10021 accggcgacg cctccggcca caacatggcc accctcgcct ccgacgcgct gctggcgcac
    10081 ctgctgcaga cgatcccggg catctcctac ggctcgatct ccgggaacta ctgcacggac
    10141 aagaaggcga ccgcgatcaa cggcatcctc ggccgcggca agaacgtggt caccgagctg
    10201 gtcgtggagc gcgaggtggt ggaacgcgtc ctgcacacca cggccgccaa gatcgtcgag
    10261 ctgaacatcc gcaagaacct gctcggcacc ctgctcgccg gcggcatccg ctcggccaac
    10321 gcccactacg ccaacatgct gctcggcttc tacctggcca ccggccagga cgcggccaac
    10381 atcgtcgagg gctcccaggg cgtcaccctg gcggaggacc gcgacggcga cctctacttc
    10441 tcctgcaacc tgcccaacct catcgtcggc accgtgggca acggcaaggg cctggagttc
    10501 gtggagacga acctgaaccg cctcggctgc cgcgaagacc gcgcccccgg cgagaacgcc
    10561 cgccggctcg ccgtcatcgc agcggcgacg gtcctctgcg gcgagctctc ccttctcgcg
    10621 gcccagacca acccgggcga actcatgcgc gcacacgtcg aactggagcg cgacaacacg
    10681 acagcagagg tcggtgtctg agaatgtccc acgagtcttt cttcggaatc cacgatctgt
    10741 ccttcgcgac gaccgagtac gtcctgtcgc acgaggcgct cgccgagtac aacggcaccg
    10801 agatcggcaa gtaccacatc ggcatcggcc agcggtcgat gagcgtgccc gccgcggacg
    10861 aggacatcgt gacgctgggc gccgccgccg ccgccccgat catcgcccgg cacggttccg
    10921 gacggatccg aacggtggtc ttagcgacgg aatcctcgat cgaccaggcg aagtccgcag
    10981 gcgtgtacgt gcactcactg ctcggcctgc catcggcctg ccgcgtcgtc gaactgaagc
    11041 aggcctgcta cggagccacg gccgccctgc agttcgccat cggactcgta cggcgcgacc
    11101 ccgaccagca ggtcctcgtg atcgcgagcg acgtctccaa gtacgaactg gacagccccg
    11161 gcgaggcgac ccagggcgcc gccgcggtgg cgatgctggt cagcgccgac cccgccctgg
    11221 tccgcatcga gaacccctca ggactgttca cggccgacgt catggacttc tggcggccga
    11281 actacctcac caccgccctg gtcgacgggc aggaatccgt ccaggcgtac ctgcaggcgg
    11341 tcgcgagcag ctggaaggac tacggcgagc agggcggccg cgcactcgac gagttcgccg
    11401 cgttctgcta ccaccaaccg ttcacgaaga tggcctacaa ggcacaccac cacctgctca
    11461 actacgcggg ccaggaaacc gacaaggccg acatcgagca tgccatcggg cggaccgtgg
    11521 cctacaacgc caccatcggc aacagctaca ccgcctcggt gtacctcgct ctcgccgcgc
    11581 tgctcgacca ggcggacgac ctgaccgacc gacccatcgg cttcctcagc tacggctccg
    11641 gcagcgtcgc cgagttcttc gcgggcaccg ccgcccccgg ctaccgcgaa cacctgcgga
    11701 ccgaggcgaa cctggaggcg atagcccggc gcaagccggt cgaccacgcc cgctaccgcg
    11761 agctgcacga gcggtccttc ccggccgacg gaggagaaca cctcaccccg cagcagacca
    11821 ccggcccctt ccgcctggcc ggcctcagcg gtcacaagcg catctaccag gcgcgctaga
    11881 acacctccgg tcccgcgggt gcgggggcgg cctccacggt cgcccccgct acggccgcac
    11941 gccagttttc acacaccgtt ctccatacca cttgagggga gggcagccgt atgaccgacc
    12001 tcaggattct cggtacgggt gcctatgtgc cggagcgaat cgcgtccaat gacgaggtcg
    12061 ccgcggcggc gggggtcgac gacgcgtgga tcaccgccaa gaccggcatc cgggaacggc
    12121 gatgggctgc cgacgaccag gccacctcgg acctggccac cgccgcgggg cgggccgcgc
    12181 tgcggtcggc cggcatcacc gccgaggacc tgtccgtgat cgtggtcgcc acgtccacac
    12241 ccgaccggcc ccaaccgccc accgccgcct acgtccagca gcggctcggc gcgagcgacg
    12301 cggccgcgtt cgacgtcaac gcggtctgct ccggcatggt gttcgcgctc gccgcggccg
    12361 agggcgtact cacccgcacc ggcggccacg cactggtcat cggcgcggac ctgtattccc
    12421 gcatcctgaa ccgggccgac cgcaggaccg tgatcctttt cggggacggt gccggagcgg
    12481 tgatcctggg gtcgtcggtc gaccacggac cacgtatccg gcacctcgcg ctgcactcgt
    12541 tcggcgaact gtcggggctc atcgaggtgc ccgccggcgg cagtcgcatg cccgtggacc
    12601 agacagtcct cgacgcaggg cttcagtact tcgcgatgga cgggcgaggc gtgcggaact
    12661 tcgtctgtga ccacctgccg cagctggtca agggattcct gcacaaatgc ggtgtcgtac
    12721 ccgacgacat cgaccacttc gtaccgcacc aggccaacgg caccatgctg gacagcctct
    12781 tcgccgattt ggaactgcct cgcgcgacca tgcaccgcac actgacgcac tacgccaaca
    12841 cgggagccgc ctccatcccg atcaccctgg acgcggccgc ccgcgccggc gccttcaacc
    12901 ccggcgacct gatcctcatg gccggcttcg gcggcggcat gtcggcggga ttcgcgctgg
    12961 tcgagtggtg agagaactca ggccggtggg tgggtggctg tctcggcgaa cccgtcggag
    13021 cgttcggaag ggctgccctt cgcagctcgt ccggcttcac agcgacgaac gggagctcag
    13081 gatccaccga tgacgacgcc gaaccgcttc ccactcgcat ccggcggacg cggtggcgga
    13141 gaagttcggc ggcgactcgg tgcccgagac ccggcgcaac gtccagtcgt acctcggcca
    13201 ggtgccccgg tacccaatcg attccgaagg caaggggaac aagtgacaga ccgtccgttc
    13261 tacgtgctgc tggggccgga ctacgccggg aagtcctccg tgatgacgga gctctcggcg
    13321 gcgatgcccg gctggcagac cctgtcgacc gacgacgacc tcgtggccgg ggagcaccgt
    13381 ctgatctcgc agctgcgccg gaacgtcgtc cgggacgtgc tgccgggcct ggggcccacg
    13441 tactccgccg acttcctcgc gagtctgctg ggcacggccg tcgtgcacct gagggatcag
    13501 ctcgaacggc aggagccgga cgtgccggtc ttgatggact cgtactacta caagatcctc
    13561 gcgaagtgtc gactcgccgg gcttgaaatg caccccctgt acacctggtg gcgttccttt
    13621 cccctgccgc gcggagtgat ctatctggac gtctcgcccg agaccgcctg gcgtcgctcg
    13681 ggacgcggag cgcagctcaa ccccctcgag cacttcggcg accggcccga gtggttcggc
    13741 ttcgagagct atcagaagaa cctcggcaag ctgttgctgg aggaaacggg acaactgccc
    13801 gtcacggtgg tcgaggagcg gtccgggacg gctgcgaccg ccgcggccgt gcgggaggtc
    13861 ctggcggcat gagcgagacc cagggctggg gcacacccgg ccacgccgac cgctaccggg
    13921 agcgggtgtt cgccgagcgg gcgcagctga gcgcgggcct cgacgacctg ccgcaacagc
    13981 aacaacgtgt gctggacgat ctgttggagt tcaacggcgg taccgagttc ggacgccgcc
    14041 acggcttcgc cgcaatccgt actctgaagg actaccgggc ggccgtgccc atccaggact
    14101 acgcggcgca cgccccgctg atcgaacgca tggcggcggg cgagccgaac ctgctgaccc
    14161 aggacgcgcc ggtggtgtac ttcaccagca gcggaagcac cggggaccac aagaagatcc
    14221 cgatcacccg ccgcttcatg aagaccgtct tcttcccctt ctactacgcg gcctgggcgc
    14281 cgttgatcga aagtctcccg gagctcatgg agcgcccgga cgcggtgctg aacctcaagc
    14341 acgatccgct cgccgttcct cccgtcacga ccagcgggcg tccccatgtg ggggccagcc
    14401 aggtcgactt cggcgcggcg ttcggcgaac cgctctcggc cgaactgggc accgccgcgc
    14461 cctgggccac ccttcccgtg gacgtcgcgc ccgacgacca cctggagaag atgtacctgc
    14521 ggttgcgact ggcggtgcag agcgacgtgc ggggcctcat cgggatcaac ccggcgatga
    14581 tcgcggccgt gccctatcag ctcgagctgt ggtggcagcg catcgtcaag gaggtccgcg
    14641 acgggaccct gggcggagtg ccgtacgggg accccgatcc ggagcgcgcc gcccggctgg
    14701 agttcctcgc cggccacttc ggacggccca gcccggctca cgtctggccg caggttcgag
    14761 cgttgtttgg ctggtcgacc ggcgtggcct ccctgtacat gccgggcctg cgtgagcggt
    14821 tcggggctgg agtcagggtc ctgcccgcgc cggtggccgc gtcggagggg ccggtggcgg
    14881 tgccgctcga ccggcacccc gccgcgggca gcctcgtccc ctccgccgcc gtgtacgagt
    14941 tcgtggacgc cgacgaggac ctcggccccg gcgccgagac gctcgtggcg gaggaactcg
    15001 aaccgaaccg ggactaccac gtgctcttca gccacgtcgg aggcctctac cggtacgccg
    15061 tcggggacgt ggtccgcgtg gtggaccgtg tccggggggt gccgcgggtc ctgtacgcgg
    15121 gccgtgccac ccggtcggat gcggccgggg agcggctgcg cgaggcccag gtggtgcggg
    15181 cgttgggaga agcactggcg agcactggcc tcgcgctgcg caacgtggcg tgccgggtgg
    15241 aggaaacggc gggcgaggcg ccccggtatg tgttcgcggt ggccccggag gctccgtggc
    15301 tggagtccga gaccgtgcgg ttcgccagac tgctcgatgc ggcgctcgcc gccgagtccc
    15361 cgggatacgc cagggctctg cgggagcggc ggctcggtgc cgcgacgctg cggctgctgc
    15421 acatcgacgc cttccagcgc gagtggcacg cccgcgtggc ggacggcgtc cggcccaccc
    15481 aggtcaagga ccggctgttc cggcaggacg agagccagtg gcggcgactg atcgccgcgt
    15541 ccgacgcact acgaggagaa ggcacatgat gcatgtccag gatcccgtcg accccgtgga
    15601 gacgactgcc ctgctgaccg ccgccctgcg cgccgccgag agcgggcggg aggaccggct
    15661 ctacaaggat ccgtacgcgg ccgcgctggt gggggacgca ggcccccggc tcctggcgga
    15721 gatccgtgcc gcgaccttcc cgccggacgg gccgcggagc gtgcccagta cccccgacta
    15781 caacgcgatc cgcaccagat tcttcgatga cctcctccaa gaggccgtac aggaccaggg
    15841 gatgacccag ctcgtcgtgg ccccggccgg catggactcc cgtgcctacc ggctgccctg
    15901 gccgcgacac ctgcggtact tcgaggtcga ccggccgtcg gtgctcgcgt tcaaggagga
    15961 gcgcctgcgc ggggtcgacc cgcgcgtcga ccacgtcacc gtcgccgtcg acctgaccgc
    16021 ggacgactgg gaggaccggc tccgcgcctc cggatacgac ccgagcacgc cgtccacctg
    16081 gctgctcgaa gggctgctgt actacatccc tgagaaggac accgagcgca tgctggagcg
    16141 ggtcggcgca ttctgtgctc cgggcagccg catcgccgcc gacctcgtca actccgcggc
    16201 cctcaccctc ccgcacatgc gtcccctcct ggacgtcttc agcggctggg gctgcccctg
    16261 gctcttcggc agcgacgagc ccgaggcgct cttcgagcgg tacggcttcg acgtggccgc
    16321 ggtccagccc ggtgagcccg gggcccactt cggacgctgg ccggacccgg tccccgaccg
    16381 cgccgtcaag gacgtgcggc gggtgttctt cgtgcacggc caacgccggt gaccgggccc
    16441 gtcgtggtgg gcggcagcgt cgcggggctc gccgccggcc tcgccctggc gttacggggc
    16501 ctgcccgtcc gggtgctgga gcaggcgccc gtaccgccgg aagggccgcc ggggaaggcg
    16561 gccgagctgt ggaagaggcc cactgtcgcg cagaacggcc actcccacgt cctgacctcg
    16621 ctcggcgtac gggtgctgcg ggcccacgtc cctcaggtgc tcgacgccgc tttggaggcc
    16681 ggcgcacgca tgctcgacct catgcgggcg ctgccggtac gggccgacga tgggatccgc
    16741 cgccagggcg acgaggaact cgtggccctc gccgtgcgcc gcccggtctt cgaactcgtc
    16801 ctccgccagg cgctgcggtc gctgccgaac gtcacgatca gccatgacgt caaggtcata
    16861 ggcctgcgca cgacgccctc ggggaaccgg gtgacgggcc tggtgaccgg cgacggcgag
    16921 gacatcccca cgcatacggt cgtggacgcc accggacgcc ggtcggcgtc gcggtcctgg
    16981 ctcaccgccg ccggatttcc cccggaagcc gcgaggaccg cccccacccg ggtgcgcgcc
    17041 ttcacccgct tctaccggct caggtccccc ggcacgctgc ccggaccgct caaccgcggc
    17101 aacgcggcgg gcggcatctg ggaccactac gcggcggtcg cacacctcgc cgacaacgac
    17161 acgtacgccc tgaccgtcgg cgtgcccact gcggatccgg cgacgacagg cctgcggcat
    17221 ccggccgcct tcaccgcggt cgcccgtctt tcgccgtacc tcgccgcctg ggccgatccc
    17281 gcggtggggg agccgatcag cgcggtgcga gccatcaccc tgccgcccaa cacgctgcac
    17341 tgcgcacccg acgccggcgc cgggccgatc gcgggcctgt acccggtcgg ggacgccgcg
    17401 tgtgtcaccg acccgctctt cgggcggggc atgtcgctgg ccctgcggca cgctttcctg
    17461 ctcgcggatt tcctggcgga cgagccggcg gtcgaggagc agggtgaacg tgccgcacgc
    17521 atcgccgacg gcgtctaccg gtcgtggtac gagcagtccg tccgcgagga cgcggcacgc
    17581 acggccctgt ggcaggcgag ggtcacggga tgcccgccgc cgacggtatc ggagtccggc
    17641 cgcgcagcac tgtccgaagt cgcccgggcg gcggccgccg acgggaccgt gtggcgcggc
    17701 ctcacccgcg tgctgatggg cctggagacc gtcgaggacg tcttcgacga cgaggcgttc
    17761 cgccgacggg tacggacggc ccccgaaccg gccgcggccg cgccgcgccc actgacgcgg
    17821 gaggaactgg tcgccgccgt cagagacgag gtgcgcgcat gaccgcgtcg gaccgttccc
    17881 agacgcgccg tcgaaaggtg ctgctcgcac ccgtcacggt taccccggcc aaaccgctca
    17941 cacccagcca cctcaaaggt ctgctgtgga ccgacgtcat gttccgggcc accgcgccgc
    18001 tcgcggacgt gacctaccgc tacagcccca cgacctacca cctcaccgaa cagaccctag
    18061 gattctggga gttcctcgac cgcacgcaga agggcctgcc ctacgcctca ctttccgagg
    18121 aggagatcgg cgagctgtac gtccggttcc gggcctgcgc gcccccaccg gccgacgcct
    18181 tgcgccccta cgcacaccag gtcgagagca acggctgggt gcacccggcc agtgaacgcg
    18241 ttctgcgcct gtggcgcgag cactacgctc aactcggact ccacgaccct ggcctgacgg
    18301 tccatcaacc gccagggctc ggcacggagg agatgatcga acggctcgtc gccctcggcc
    18361 tggggctcga ccatcgctcc agcggcggtc ccgtgtacct cgacgccact cggcacggtc
    18421 tgcccctgcg ccagatcgtg acggcggacg gccgcccgaa ctaccttgcc tgcgccctgc
    18481 gggaactgct tccgctggca cccgcgtatg acgaggtcgt gctcctgtac gacaccgatc
    18541 tcgacgcgga ctaccggctg ctgcagcgcg cgctgaccca gctggggccg ctggtgcacc
    18601 gcgtcccgat cggtcgcgtg cccatcgacg gcacgatcag atcggcgcgg cacggcggct
    18661 ggcacgctta cacggcgggc gccctgctca aggccgtcgg cacggaggcc gacgcggacg
    18721 tacgccgtct cggcgtacgg ctgtacttcg tcgccgtcct cggtcccgga caggcgcagt
    18781 ccttccgcac cgacctgctt cacaggagcc tggaccgggc gcggcagctg ctgcgccgga
    18841 cgaccgagcg cgggcccggc acttcgcctc tcgtggacga cctgcgccgg caccggcgcg
    18901 accacaccca tgtcgatccc tatcggctca cctcgtccct gctggcccgg gcccgccgca
    18961 ccatcgaccg cgacctgctc tccacggtgt acctatgagc ctctcccccg agctgctgct
    19021 caccgtcgcc gccgaacgcc tgcgggccgc ccgccccgac ctcgcggccc atgcgacccc
    19081 ggtcaccccg caatccctgc tcgcggcgaa gaagcagatc gaggacgacg ccgtcggccg
    19141 caccgacgag gtgtcggcgg tcgccgtcgt ccgcgacgtc cgactcgtct cctgggtacg
    19201 ggagacctgc gcgttcgtgc tgtccctgcc gccggagcag gccgacgcct ggcgccgctc
    19261 cttcacccgg accctctacc tggccggccg ccccgacaac ctgagcgagc ggttcacttt
    19321 cgcgcacatc gccgccgacg gctcggccgc ctggaccggt ccgctgccgg acgaggccac
    19381 gaccggcctg cgcagactgc tcaagacgtt cagcggacga ggtccgctgc cggcctggcg
    19441 gcccgtcacc gtcgacctgc ag
//
