BGC0000287 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0000287 (Pseudomonas aeruginosa PAO1)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	NRPS	1	13,011	L-2-amino-4-methoxy-trans-3-butenoic acid	NRPS:Type I	100%

BGC0000287 - Region 1 - NRPS

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Location: 1 - 13,011 nt. (total: 13,011 nt) Show pHMM detection rules used

Region on contig edge.

NRPS: cds(Condensation and (AMP-binding or A-OX))

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

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Gene details

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Gene overview

MIBiG

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 13,012
Label		BGC0000287

Detailed domain annotation

Selected features only

Show module domains

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000287	1.00	NRP	L-2-amino-4-methoxy-trans-3-butenoic acid	Pseudomonas aeruginosa PAO1
BGC0000375	0.35	NRP	indigoidine	Streptomyces chromofuscus
BGC0001527	0.33	Other	basidioferrin	Gelatoporia subvermispora
BGC0002710	0.32	NRP	metachelin C, metachelin A, metachelin A-CE, metachelin B, dimerumic acid 11-mannoside, dimerumic acid	Metarhizium robertsii ARSEF 23
BGC0001249	0.32	NRP	dimethylcoprogen	Alternaria alternata
BGC0000979	0.26	NRP, Polyketide	cylindrospermopsin	Aphanizomenon sp. 10E9
BGC0000980	0.26	NRP, Polyketide	cylindrospermopsin	Aphanizomenon sp. 22D11
BGC0002002	0.26	NRP	1,6-phenazinedimethanol, fontizine A	Serratia fonticola
BGC0001561	0.25	NRP	curacomycin	Streptomyces curacoi
BGC0001261	0.25	NRP	AM-toxin	Alternaria alternata

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000287	1.00	NRP	L-2-amino-4-methoxy-trans-3-butenoic acid	Pseudomonas aeruginosa PAO1
BGC0000375	0.68	NRP	indigoidine	Streptomyces chromofuscus
BGC0001527	0.66	Other	basidioferrin	Gelatoporia subvermispora
BGC0002710	0.65	NRP	metachelin C, metachelin A, metachelin A-CE, metachelin B, dimerumic acid 11-mannoside, dimerumic acid	Metarhizium robertsii ARSEF 23
BGC0001249	0.65	NRP	dimethylcoprogen	Alternaria alternata
BGC0000979	0.60	NRP, Polyketide	cylindrospermopsin	Aphanizomenon sp. 10E9
BGC0000980	0.60	NRP, Polyketide	cylindrospermopsin	Aphanizomenon sp. 22D11
BGC0002002	0.59	NRP	1,6-phenazinedimethanol, fontizine A	Serratia fonticola
BGC0001561	0.59	NRP	curacomycin	Streptomyces curacoi
BGC0001261	0.58	NRP	AM-toxin	Alternaria alternata

Similar known gene clusters from MIBiG 4.0

Module view

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NRPS/PKS products

NRPS/PKS substrates

Predicted core structure(s)

For candidate cluster 1, location 0 - 13011:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (Ala) + (X)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

PA2302

AMP-binding (454..848): X

nrpys: Asp, Asn, Glu, Gln, Aad

SVM prediction details:

Predicted physicochemical class:: hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
Large clusters prediction:: Aliphatic chain with H-bond donor (Asp, Asn, Glu, Gln, Aad)
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DSKDLGLVNK
Nearest Stachelhaus code(s):: Glu DAKDLGVVDK (65% 8Å match)
Stachelhaus code match:: 70% (weak)

PA2305

Search NORINE for peptide: strict or relaxed

AMP-binding (244..633): Ala

nrpys: Ala

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
Small clusters prediction:: Tiny, hydrophilic, transition to aliphatic (Gly, Ala)
Single AA prediction:: ala (Ala)

Stachelhaus prediction details:

Stachelhaus sequence:: DLYNNALTYK
Nearest Stachelhaus code(s):: Ala DLYNNALTYK (88% 8Å match)
Stachelhaus code match:: 100% (strong)