BGC0000289: A40926 biosynthetic gene cluster from Nonomuraea gerenzanensis
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Location: 1 - 89,153 nt. (total: 89,153 nt).
This entry is originally from NCBI GenBank AJ561198.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
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Gene details
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General
Compounds
Genes
Biosynthesis
History
Tailoring
KnownClusterBlast
NRPS/PKS domains
General information about the BGC
MIBiG accession BGC0000289
Short description A40926 biosynthetic gene cluster from Nonomuraea gerenzanensis
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: complete
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRPS (Type I)
  • saccharide (hybrid/tailoring)
Loci
AJ561198.1
via Knock-out studies, Enzymatic assays, Gene expression correlated with compound production
Compounds
  • A40926
Species Nonomuraea gerenzanensis [taxonomy]
References
Chemical products information
A40926 Evidence:
(no structure information available)
Chemical database entries
ChemSpider
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • CAD91190.1
 <1 - 141 (-) hypothetical protein
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    • CAD91191.1
    		 347 - 1207 (-) hypothetical protein
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      • CAD91192.1
      		 1797 - 2627 (-) hypothetical protein
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        • CAD91193.1
        		 3225 - 4181 (-) hypothetical protein
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          • CAD91194.1
          		 4178 - 4690 (-) hypothetical protein
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            • CAD91195.1
            		 4838 - 6202 (+) hypothetical protein
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              • CAD91196.1
              • dbv1
              		 6242 - 7342 (-) putative hydroxymandelate oxidase
              • Precursor biosynthesis
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              • CAD91197.1
              • dbv2
              		 7461 - 8531 (-) putative hydroxymandelate synthase
              • Precursor biosynthesis
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              • CAD91198.1
              • dbv3
              		 8760 - 11363 (-) putative regulator LuxR family
              • Regulation
              • Knock-out
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              • CAD91199.1
              • dbv4
              		 11468 - 12433 (-) putative regulator StrR family
              • Regulation
              • Activity assay
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              • CAD91200.1
              • dbv5
              		 13385 - 14494 (+) putative prephenate dehydrogenase
              • Precursor biosynthesis
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              • CAD91201.1
              • dbv6
              		 14522 - 15175 (+) putative response regulator
              • Regulation
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              • CAD91202.1
              • dbv7
              		 15271 - 15861 (+) putative VanY-type carboxypeptidase
              • Resistance/immunity
              • Other in vivo study
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              • CAD91203.1
              • dbv8
              		 15910 - 16869 (-) Dbv8 protein
              • Tailoring
              • Activity assay
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              • CAD91204.1
              • dbv9
              		 16872 - 18098 (-) glycosyltransferase
              • Tailoring
              • Activity assay
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              • CAD91205.1
              • dbv10
              		 18152 - 19621 (-) halogenase
              • Tailoring
              • Knock-out
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              • CAD91206.1
              • dbv11
              		 19681 - 20943 (-) putative oxygenase OxyC
              • Scaffold biosynthesis
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              • CAD91207.1
              • dbv12
              		 21025 - 22221 (-) putative OxyB monooxigenase
              • Scaffold biosynthesis
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              • CAD91208.1
              • dbv13
              		 22211 - 23365 (-) putative monooxygenase
              • Scaffold biosynthesis
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              • CAD91209.1
              • dbv14
              		 23387 - 24568 (-) putative OxyA monooxygenase
              • Scaffold biosynthesis
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              • CAD91210.1
              • dbv15
              		 24664 - 24873 (-) Dbv15 protein
              • Scaffold biosynthesis
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              • CAD91211.1
              • dbv16
              		 24870 - 30461 (-) putative non-ribosomal peptide synthetase, module 7
              • Scaffold biosynthesis
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              • CAD91212.1
              • dbv17
              		 30480 - 42731 (-) putative non-ribosomal peptide synthetase, modules 4-6
              • Scaffold biosynthesis
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              • CAD91213.1
              • dbv18
              		 42962 - 45223 (-) putative ABC transporter, Dbv18
              • Transport
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              • CAD91214.1
              • dbv19
              		 45355 - 46053 (-) putative ABC transporter, Dbv19
              • Transport
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              • CAD91215.1
              • dbv20
              		 46327 - 47934 (-) putative mannosyltransferase
              • Tailoring
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              • CAD91216.1
              • dbv21
              		 47974 - 48786 (-) Dbv21 protein
              • Tailoring
              • Activity assay
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              • CAD91217.1
              • dbv22
              		 49070 - 50332 (-) putative sensory kinase
              • Regulation
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              • CAD91218.1
              • dbv23
              		 50428 - 52557 (-) putative acyltransferase
              • Tailoring
              • Knock-out
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              • CAD91219.1
              • dbv24
              		 52834 - 54780 (+) putative ABC transporter, Dbv24
              • Transport
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              • CAD91220.1
              • dbv25
              		 54777 - 61070 (+) putative non-ribosomal peptide synthetase, modules 1-2
              • Scaffold biosynthesis
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              • CAD91221.1
              • dbv26
              		 61067 - 64258 (+) putative non-ribosomal peptide synthetase, module 3
              • Scaffold biosynthesis
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              • CAD91222.1
              • dbv27
              		 64354 - 65187 (+) putative methyltransferase
              • Tailoring
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              • CAD91223.1
              • dbv28
              		 65248 - 66843 (+) putative beta-hydroxylase
              • Tailoring
              • Knock-out
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              • CAD91224.1
              • dbv29
              		 67076 - 68647 (-) putative hexose oxidase
              • Tailoring
              • Activity assay
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              • CAD91225.1
              • dbv30
              		 69089 - 69514 (+) Dbv30 protein
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                • CAD91226.1
                • dbv31
                		 69671 - 70789 (+) putative DpgA protein
                • Precursor biosynthesis
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                • CAD91227.1
                • dbv32
                		 70801 - 71442 (+) putative DpgB protein
                • Precursor biosynthesis
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                • CAD91228.1
                • dbv33
                		 71439 - 72743 (+) putative DpgC protein
                • Precursor biosynthesis
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                • CAD91229.1
                • dbv34
                		 72740 - 73537 (+) putative DpgD protein
                • Precursor biosynthesis
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                • CAD91230.1
                • dbv35
                		 73534 - 74820 (+) putative integral membrane ion antiporter
                • Transport
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                • CAD91231.1
                • dbv36
                		 74887 - 75642 (-) putative type II thioesterase
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                  • CAD91232.1
                  • dbv37
                  		 75810 - 77096 (+) putative HpgT aminotransferase
                  • Precursor biosynthesis
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                  • CAD91233.1
                  		 77423 - 77842 (+) hypothetical protein
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                    • CAD91234.1
                    		 77990 - 78658 (+) hypothetical protein
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                      • CAD91235.1
                      		 78655 - 79155 (+) hypothetical protein
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                        • CAD91236.1
                        		 79142 - 80188 (-) hypothetical protein
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                          • CAD91237.1
                          		 80333 - 81178 (-) hypothetical protein
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                            • CAD91238.1
                            		 81706 - 83250 (+) hypothetical protein
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                              • CAD91239.1
                              		 83696 - 84547 (-) hypothetical protein
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                                • CAD91240.1
                                		 84588 - 85538 (-) hypothetical protein
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                                  • CAD91241.1
                                  		 85535 - 86311 (-) hypothetical protein
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                                    • CAD91242.1
                                    		 86308 - 87483 (-) hypothetical protein
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                                      • CAD91243.1
                                      		 87476 - 88129 (-) hypothetical protein
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                                        • CAD91244.1
                                        		 88596 - >89153 (+) hypothetical protein
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                                          Biosynthesis information

                                          Biosynthetic modules

                                          Name
                                          1
                                          Type
                                          nrps-type1
                                          Genes
                                          dbv25
                                          Substrates
                                          4-hydroxyphenylglycine (evidence: Sequence-based prediction)
                                          Integrated Monomers
                                          Domains
                                          adenylation, epimerase
                                          Name
                                          2
                                          Type
                                          nrps-type1
                                          Genes
                                          dbv25
                                          Substrates
                                          tyrosine (evidence: Sequence-based prediction)
                                          Integrated Monomers
                                          Domains
                                          condensation, adenylation, epimerase
                                          Name
                                          3
                                          Type
                                          nrps-type1
                                          Genes
                                          dbv26
                                          Substrates
                                          3,5-dihydroxyphenylglycine (evidence: Sequence-based prediction)
                                          Integrated Monomers
                                          Domains
                                          condensation, adenylation
                                          Name
                                          4
                                          Type
                                          nrps-type1
                                          Genes
                                          dbv17
                                          Substrates
                                          4-hydroxyphenylglycine (evidence: Sequence-based prediction)
                                          Integrated Monomers
                                          Domains
                                          condensation, adenylation, epimerase
                                          Name
                                          5
                                          Type
                                          nrps-type1
                                          Genes
                                          dbv17
                                          Substrates
                                          4-hydroxyphenylglycine (evidence: Sequence-based prediction)
                                          Integrated Monomers
                                          Domains
                                          condensation, adenylation, epimerase
                                          Name
                                          6
                                          Type
                                          nrps-type1
                                          Genes
                                          dbv17
                                          Substrates
                                          tyrosine (evidence: Sequence-based prediction)
                                          Integrated Monomers
                                          Domains
                                          condensation, adenylation
                                          Name
                                          7
                                          Type
                                          nrps-type1
                                          Genes
                                          dbv16
                                          Substrates
                                          3,5-dihydroxyphenylglycine (evidence: Sequence-based prediction)
                                          Integrated Monomers
                                          Domains
                                          condensation, adenylation
                                          Annotation changelog

                                          Entry version: 4

                                          Date
                                          Changes
                                          Submitters
                                          Reviewers
                                          2022-10-07
                                          Update chemical activity to schema version 2.11
                                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                          Entry version: 3

                                          Date
                                          Changes
                                          Submitters
                                          Reviewers
                                          2022-09-15
                                          Corrected NRP module activity
                                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                          2022-09-15
                                          Removed gene names of 'No gene ID'
                                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                          2022-09-15
                                          Removed duplicate gene name
                                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                          2022-09-15
                                          Corrected gene identifiers
                                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                          2022-09-15
                                          Updated NRP substrate specificities
                                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                          Entry version: 2

                                          Date
                                          Changes
                                          Submitters
                                          Reviewers
                                          2019-10-16
                                          Migrated from v1.4
                                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                          Entry version: 1

                                          Date
                                          Changes
                                          Submitters
                                          Reviewers
                                          2015-06-12
                                          Submitted
                                          • (ID: NELCJYN3677BXW76PLWVRCJG)
                                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                          Tailoring functions
                                          Tailoring enzymes detected in this region
                                          Oxidoreductases: dehydrogenase oxidase oxygenase
                                          CAD91239.1: short-chain dehydrogenase/reductase SDR
                                          smcogs
                                          SMCOG1001: short-chain dehydrogenase/reductase SDR
                                          dbv11: Cyclization
                                          MITE
                                          MITE0000027Cyclization (identity: 72.50%)
                                          smcogs
                                          SMCOG1007: cytochrome P450
                                          dbv12: Cyclization
                                          MITE
                                          MITE0000041Cyclization (identity: 80.90%)
                                          smcogs
                                          SMCOG1007: cytochrome P450
                                          dbv13: cytochrome P450
                                          smcogs
                                          SMCOG1007: cytochrome P450
                                          dbv14: Cyclization
                                          MITE
                                          MITE0000038Cyclization (identity: 70.30%)
                                          smcogs
                                          SMCOG1007: cytochrome P450
                                          dbv29: FAD linked oxidase domain protein
                                          smcogs
                                          SMCOG1138: FAD linked oxidase domain protein
                                          Transferases: acyltransferase aminotransferase glycosyltransferase halogenase methyltransferase
                                          dbv10: flavin-dependent tyrosine-like hpg halogenase
                                          halogenases
                                          flavin-dependent tyrosine-like hpg halogenase
                                          MITE
                                          MITE0000028Halogenation (identity: 81.40%)
                                          smcogs
                                          SMCOG1119: halogenase
                                          dbv23: acyltransferase 3
                                          smcogs
                                          SMCOG1088: acyltransferase 3
                                          dbv27: methyltransferase
                                          smcogs
                                          SMCOG1248: methyltransferase
                                          dbv37: aminotransferase
                                          smcogs
                                          SMCOG1019: aminotransferase
                                          dbv9: Glycosylation
                                          MITE
                                          MITE0000033Glycosylation (identity: 74.10%)
                                          smcogs
                                          SMCOG1102: glycosyltransferase
                                          Hydrolases: Acylation dehalogenase esterase
                                          CAD91191.1: haloalkane dehalogenase
                                          smcogs
                                          SMCOG1262: haloalkane dehalogenase
                                          dbv36: thioesterase
                                          smcogs
                                          SMCOG1004: thioesterase
                                          dbv8: Acylation, Hydrolysis
                                          MITE
                                          MITE0000035Acylation, Hydrolysis (identity: 71.20%)
                                          Lyases: hydratase
                                          dbv33: enoyl-CoA hydratase
                                          smcogs
                                          SMCOG1023: enoyl-CoA hydratase
                                          dbv34: enoyl-CoA hydratase
                                          smcogs
                                          SMCOG1023: enoyl-CoA hydratase
                                          Ligases: Acylation ligase synthase
                                          dbv17: condensation domain-containing protein
                                          smcogs
                                          SMCOG1127: condensation domain-containing protein
                                          dbv25: AMP-dependent synthetase and ligase
                                          smcogs
                                          SMCOG1002: AMP-dependent synthetase and ligase
                                          dbv26: AMP-dependent synthetase and ligase
                                          smcogs
                                          SMCOG1002: AMP-dependent synthetase and ligase
                                          dbv31: chalcone and stilbene synthase domain protein
                                          smcogs
                                          SMCOG1024: chalcone and stilbene synthase domain protein
                                          dbv8: Acylation, Hydrolysis
                                          MITE
                                          MITE0000035Acylation, Hydrolysis (identity: 71.20%)
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                                          Detailed domain annotation
                                          Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
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