BGC0000289

BGC0000289: A40926 biosynthetic gene cluster from Nonomuraea gerenzanensis

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Location: 1 - 89,153 nt. (total: 89,153 nt).
This entry is originally from NCBI GenBank AJ561198.1.

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

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Gene details

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General

Compounds

Genes

NRP

Saccharide

History

NRPS/PKS domains

KnownClusterBlast

General information about the BGC

MIBiG accession	BGC0000289
Short description	A40926 biosynthetic gene cluster from Nonomuraea gerenzanensis
Status	Minimal annotation: no A minimal annotation only contains information on the BGC loci and one or more linked chemical product(s) Completeness: complete Whether the loci encodes everything needed for the pathway producing the compound(s)
Biosynthetic class(es)	NRP (Glycopeptide) Saccharide (hybrid/tailoring)
Loci	NCBI GenBank: AJ561198.1
Compounds	A40926
Species	Nonomuraea gerenzanensis [taxonomy]
References	The gene cluster for the biosynthesis of the glycopeptide antibiotic A40926 by nonomuraea species. Sosio M et al., Chem Biol (2003) PMID:12837387 Tailoring of glycopeptide scaffolds by the acyltransferases from the teicoplanin and A-40,926 biosynthetic operons. Kruger RG et al., Chem Biol (2005) PMID:15664522 Comparative analysis and insights into the evolution of gene clusters for glycopeptide antibiotic biosynthesis. Donadio S et al., Mol Genet Genomics (2005) PMID:16007453 A derivative of the glycopeptide A40926 produced by inactivation of the beta-hydroxylase gene in Nonomuraea sp. ATCC39727. Stinchi S et al., FEMS Microbiol Lett (2006) PMID:16499611 Glycopeptide biosynthesis: Dbv21/Orf2 from dbv/tcp gene clusters are N-Ac-Glm teicoplanin pseudoaglycone deacetylases and Orf15 from cep gene cluster is a Glc-1-P thymidyltransferase. Ho JY et al., J Am Chem Soc (2006) PMID:17044690 A unique flavin mononucleotide-linked primary alcohol oxidase for glycopeptide A40926 maturation. Li YS et al., J Am Chem Soc (2007) PMID:17935335 Improved production of A40926 by Nonomuraea sp. through deletion of a pathway-specific acetyltransferase. Sosio M et al., Appl Microbiol Biotechnol (2010) PMID:20414653 Phosphate-controlled regulator for the biosynthesis of the dalbavancin precursor A40926. Alduina R et al., J Bacteriol (2007) PMID:17873036

Chemical products information

A40926

(no structure information available)

Chemical database entries
ChemSpider

List of genes involved in compound(s) production

Identifiers	Position	Product	Functions	Evidence	Extra
CAD91190.1	1 - 141 (-)	hypothetical protein	Unknown	Sequence-based prediction	copy AA seq copy Nt seq
CAD91191.1	347 - 1207 (-)	hypothetical protein	Unknown	Sequence-based prediction	copy AA seq copy Nt seq
CAD91192.1	1797 - 2627 (-)	hypothetical protein	Unknown	Sequence-based prediction	copy AA seq copy Nt seq
CAD91193.1	3225 - 4181 (-)	hypothetical protein	Unknown	Sequence-based prediction	copy AA seq copy Nt seq
CAD91194.1	4178 - 4690 (-)	hypothetical protein	Unknown	Sequence-based prediction	copy AA seq copy Nt seq
CAD91195.1	4838 - 6202 (+)	hypothetical protein	Unknown	Sequence-based prediction	copy AA seq copy Nt seq
CAD91196.1 dbv1	6242 - 7342 (-)	putative hydroxymandelate oxidase	Precursor biosynthesis	Sequence-based prediction	copy AA seq copy Nt seq
CAD91197.1 dbv2	7461 - 8531 (-)	putative hydroxymandelate synthase	Precursor biosynthesis	Sequence-based prediction	copy AA seq copy Nt seq
CAD91198.1 dbv3	8760 - 11363 (-)	putative regulator LuxR family	Regulation	Knock-out	copy AA seq copy Nt seq
CAD91199.1 dbv4	11468 - 12433 (-)	putative regulator StrR family	Regulation	Activity assay	copy AA seq copy Nt seq
CAD91200.1 dbv5	13385 - 14494 (+)	putative prephenate dehydrogenase	Precursor biosynthesis	Sequence-based prediction	copy AA seq copy Nt seq
CAD91201.1 dbv6	14522 - 15175 (+)	putative response regulator	Regulation	Sequence-based prediction	copy AA seq copy Nt seq
CAD91202.1 dbv7	15271 - 15861 (+)	putative VanY-type carboxypeptidase	Resistance/immunity	Other in vivo study	copy AA seq copy Nt seq
CAD91203.1 dbv8	15910 - 16869 (-)	Dbv8 protein	Tailoring (Acylation)	Activity assay	copy AA seq copy Nt seq
CAD91204.1 dbv9	16872 - 18098 (-)	glycosyltransferase	Tailoring (Glycosylation)	Activity assay	copy AA seq copy Nt seq
CAD91205.1 dbv10	18152 - 19621 (-)	halogenase	Tailoring (Halogenation)	Knock-out	copy AA seq copy Nt seq
CAD91206.1 dbv11	19681 - 20943 (-)	putative oxygenase OxyC	Scaffold biosynthesis	Sequence-based prediction	copy AA seq copy Nt seq
CAD91207.1 dbv12	21025 - 22221 (-)	putative OxyB monooxigenase	Scaffold biosynthesis	Sequence-based prediction	copy AA seq copy Nt seq
CAD91208.1 dbv13	22211 - 23365 (-)	putative monooxygenase	Scaffold biosynthesis	Sequence-based prediction	copy AA seq copy Nt seq
CAD91209.1 dbv14	23387 - 24568 (-)	putative OxyA monooxygenase	Scaffold biosynthesis	Sequence-based prediction	copy AA seq copy Nt seq
CAD91210.1 dbv15	24664 - 24873 (-)	Dbv15 protein	Scaffold biosynthesis	Sequence-based prediction	copy AA seq copy Nt seq
CAD91211.1 dbv16	24870 - 30461 (-)	putative non-ribosomal peptide synthetase, module 7	Scaffold biosynthesis	Sequence-based prediction	copy AA seq copy Nt seq
CAD91212.1 dbv17	30480 - 42731 (-)	putative non-ribosomal peptide synthetase, modules 4-6	Scaffold biosynthesis	Sequence-based prediction	copy AA seq copy Nt seq
CAD91213.1 dbv18	42962 - 45223 (-)	putative ABC transporter, Dbv18	Transport	Sequence-based prediction	copy AA seq copy Nt seq
CAD91214.1 dbv19	45355 - 46053 (-)	putative ABC transporter, Dbv19	Transport	Sequence-based prediction	copy AA seq copy Nt seq
CAD91215.1 dbv20	46327 - 47934 (-)	putative mannosyltransferase	Tailoring (Glycosylation)	Sequence-based prediction	copy AA seq copy Nt seq
CAD91216.1 dbv21	47974 - 48786 (-)	Dbv21 protein	Tailoring (Unknown)	Activity assay	copy AA seq copy Nt seq
CAD91217.1 dbv22	49070 - 50332 (-)	putative sensory kinase	Regulation	Sequence-based prediction	copy AA seq copy Nt seq
CAD91218.1 dbv23	50428 - 52557 (-)	putative acyltransferase	Tailoring (Acetylation)	Knock-out	copy AA seq copy Nt seq
CAD91219.1 dbv24	52834 - 54780 (+)	putative ABC transporter, Dbv24	Transport	Sequence-based prediction	copy AA seq copy Nt seq
CAD91220.1 dbv25	54777 - 61070 (+)	putative non-ribosomal peptide synthetase, modules 1-2	Scaffold biosynthesis	Sequence-based prediction	copy AA seq copy Nt seq
CAD91221.1 dbv26	61067 - 64258 (+)	putative non-ribosomal peptide synthetase, module 3	Scaffold biosynthesis	Sequence-based prediction	copy AA seq copy Nt seq
CAD91222.1 dbv27	64354 - 65187 (+)	putative methyltransferase	Tailoring (Methylation)	Sequence-based prediction	copy AA seq copy Nt seq
CAD91223.1 dbv28	65248 - 66843 (+)	putative beta-hydroxylase	Tailoring (Hydroxylation)	Knock-out	copy AA seq copy Nt seq
CAD91224.1 dbv29	67076 - 68647 (-)	putative hexose oxidase	Tailoring (Oxidation)	Activity assay	copy AA seq copy Nt seq
CAD91225.1 dbv30	69089 - 69514 (+)	Dbv30 protein	Unknown	Sequence-based prediction	copy AA seq copy Nt seq
CAD91226.1 dbv31	69671 - 70789 (+)	putative DpgA protein	Precursor biosynthesis	Sequence-based prediction	copy AA seq copy Nt seq
CAD91227.1 dbv32	70801 - 71442 (+)	putative DpgB protein	Precursor biosynthesis	Sequence-based prediction	copy AA seq copy Nt seq
CAD91228.1 dbv33	71439 - 72743 (+)	putative DpgC protein	Precursor biosynthesis	Sequence-based prediction	copy AA seq copy Nt seq
CAD91229.1 dbv34	72740 - 73537 (+)	putative DpgD protein	Precursor biosynthesis	Sequence-based prediction	copy AA seq copy Nt seq
CAD91230.1 dbv35	73534 - 74820 (+)	putative integral membrane ion antiporter	Transport	Sequence-based prediction	copy AA seq copy Nt seq
CAD91231.1 dbv36	74887 - 75642 (-)	putative type II thioesterase	Unknown	Sequence-based prediction	copy AA seq copy Nt seq
CAD91232.1 dbv37	75810 - 77096 (+)	putative HpgT aminotransferase	Precursor biosynthesis	Sequence-based prediction	copy AA seq copy Nt seq
CAD91233.1	77423 - 77842 (+)	hypothetical protein			copy AA seq copy Nt seq
CAD91234.1	77990 - 78658 (+)	hypothetical protein			copy AA seq copy Nt seq
CAD91235.1	78655 - 79155 (+)	hypothetical protein			copy AA seq copy Nt seq
CAD91236.1	79142 - 80188 (-)	hypothetical protein			copy AA seq copy Nt seq
CAD91237.1	80333 - 81178 (-)	hypothetical protein			copy AA seq copy Nt seq
CAD91238.1	81706 - 83250 (+)	hypothetical protein			copy AA seq copy Nt seq
CAD91239.1	83696 - 84547 (-)	hypothetical protein			copy AA seq copy Nt seq
CAD91240.1	84588 - 85538 (-)	hypothetical protein			copy AA seq copy Nt seq
CAD91241.1	85535 - 86311 (-)	hypothetical protein			copy AA seq copy Nt seq
CAD91242.1	86308 - 87483 (-)	hypothetical protein			copy AA seq copy Nt seq
CAD91243.1	87476 - 88129 (-)	hypothetical protein			copy AA seq copy Nt seq
CAD91244.1	88596 - >89153 (+)	hypothetical protein			copy AA seq copy Nt seq

NRP-specific information

Subclass	Glycopeptide
Cyclic?	no
Release type	Hydrolysis
Thioesterase genes	dbv16 (Type I)

NRP-synthases

Gene	Modules
dbv25	Module 1 Specificity: 4-hydroxyphenylglycine Evidence for specificity: Sequence-based prediction
dbv25	Module 2 Specificity: tyrosine Evidence for specificity: Sequence-based prediction Condensation domain type: Unknown
dbv26	Module 3 Specificity: 3,5-dihydroxyphenylglycine Evidence for specificity: Sequence-based prediction Condensation domain type: Unknown
dbv17	Module 4 Specificity: 4-hydroxyphenylglycine Evidence for specificity: Sequence-based prediction Condensation domain type: Unknown
	Module 5 Specificity: 4-hydroxyphenylglycine Evidence for specificity: Sequence-based prediction Condensation domain type: Unknown
	Module 6 Specificity: tyrosine Evidence for specificity: Sequence-based prediction Condensation domain type: Unknown
dbv16	Module 7 Specificity: 3,5-dihydroxyphenylglycine Evidence for specificity: Sequence-based prediction Condensation domain type: Unknown Modification domains: Unknown

Saccharide-specific information

Subclass	hybrid/tailoring
Glycosyltransferases	dbv9 Specificity: N-acetyl-D-glucosamine Evidence: Activity assay

Annotation changelog

MIBiG version	Submitter	Notes
1.0	Hidden contributor (ID: NELCJYN3677BXW76PLWVRCJG, no GDPR consent given).	Submitted
2.0	Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).	Migrated from v1.4
3.0	Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).	Corrected NRP module activity Removed gene names of 'No gene ID' Removed duplicate gene name Corrected gene identifiers Updated NRP substrate specificities
3.1	Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).	Update chemical activity to schema version 2.11

Detailed domain annotation

Selected features only

Show module domains

Similar known gene clusters