BGC0000290: A-47934 biosynthetic gene cluster from Streptomyces toyocaensis
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Location: 1 - 69,301 nt. (total: 69,301 nt).
This entry is originally from NCBI GenBank U82965.2.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
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Gene details
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General
Compounds
Genes
Biosynthesis
History
KnownClusterBlast
NRPS/PKS domains
General information about the BGC
MIBiG accession BGC0000290
Short description A-47934 biosynthetic gene cluster from Streptomyces toyocaensis
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: complete
Whether the entry covers everything needed for the pathway producing the compound(s)
Remarks "Glycopeptide stereochemistry is known not to correlate with the presence of E domains."
Biosynthetic class(es)
  • NRPS (Type I)
Loci
U82965.2
via Enzymatic assays, Heterologous expression
Compounds
  • A-47934
Species Streptomyces toyocaensis [taxonomy]
References
Chemical products information
A-47934 Evidence:
Copy SMILES
C58H44Cl3N7O21S1
Chemical database entries
NPAtlas
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • AAM80527.1
 766 - 2022 (-) StaN
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    • AAM80528.1
    		 2485 - 4071 (-) StaM
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      • AAM80529.1
      		 4151 - 4963 (-) StaL
      • Tailoring
      • Heterologous expression Activity assay
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      • AAM80530.1
      		 4960 - 6267 (-) StaK
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        • AAM80531.1
        		 6312 - 7490 (-) StaJ
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          • AAM80532.1
          		 7534 - 9072 (-) StaI
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            • AAM80533.1
            		 9077 - 10273 (-) StaH
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              • AAM80534.1
              		 10263 - 11417 (-) StaG
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                • AAM80535.1
                		 11438 - 12613 (-) StaF
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                  • AAM80536.1
                  		 12951 - 18518 (-) StaD
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                    • AAM80537.1
                    		 18538 - 30738 (-) StaC
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                      • AAM80538.1
                      		 30768 - 35243 (-) StaB
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                        • AAM80539.1
                        		 35246 - 41458 (-) StaA
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                          • AAM80540.1
                          		 41455 - 43398 (-) StaU
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                            • AAM80541.1
                            		 43657 - 44352 (+) VanRst
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                              • AAM80542.1
                              		 44339 - 45442 (+) VanSst
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                                • AAM80543.1
                                		 45521 - 45985 (-) StaS
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                                  • AAM80544.1
                                  		 46330 - 49038 (+) StaR
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                                    • AAM80545.1
                                    		 49419 - 50222 (-) DpgD
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                                      • AAM80546.1
                                      		 50219 - 51535 (-) DpgC
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                                        • AAM80547.1
                                        		 51532 - 52209 (-) DpgB
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                                          • AAM80548.1
                                          		 52221 - 53393 (-) DpgA
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                                            • AAM80549.1
                                            		 53539 - 54897 (-) HpgT
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                                              • AAM80550.1
                                              		 55059 - 56213 (-) Pdh
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                                                • AAM80551.1
                                                		 56388 - 57497 (+) HmaS
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                                                  • AAM80552.1
                                                  		 57481 - 58581 (+) Hmo
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                                                    • AAM80553.1
                                                    		 58703 - 59704 (-) StaQ
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                                                      • AAM80554.1
                                                      		 61296 - 62138 (+) StaP
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                                                        • AAM80555.1
                                                        		 62227 - 63393 (+) StaO
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                                                          • AAC23581.2
                                                          • murX
                                                          		 63406 - 64746 (-) MurX
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                                                            • AAC23583.1
                                                            • DLDHStoy
                                                            		 64874 - 65866 (+) D-lactate dehydrogenase
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                                                              • AAC23582.2
                                                              • DdlM
                                                              		 65854 - 66894 (+) D-alanine:D-alanine ligase-related protein
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                                                                • AAD02118.1
                                                                • vanXst
                                                                		 66891 - 67517 (+) D-ala-D-ala dipeptidase
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                                                                  • AAD02119.1
                                                                  		 67715 - 69301 (+) unknown
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                                                                    Biosynthesis information

                                                                    Biosynthetic modules

                                                                    Name
                                                                    1
                                                                    Type
                                                                    nrps-type1
                                                                    Genes
                                                                    AAM80539.1
                                                                    Substrates
                                                                    4-hydroxyphenylglycine (evidence: Structure-based inference)
                                                                    Integrated Monomers
                                                                    Domains
                                                                    condensation, adenylation, epimerase
                                                                    Name
                                                                    2
                                                                    Type
                                                                    nrps-type1
                                                                    Genes
                                                                    AAM80539.1
                                                                    Substrates
                                                                    tyrosine (evidence: Structure-based inference)
                                                                    Integrated Monomers
                                                                    Domains
                                                                    condensation, adenylation, epimerase
                                                                    Name
                                                                    3
                                                                    Type
                                                                    nrps-type1
                                                                    Genes
                                                                    AAM80538.1
                                                                    Substrates
                                                                    3,5-dihydroxyphenylglycine (evidence: Structure-based inference)
                                                                    Integrated Monomers
                                                                    Domains
                                                                    condensation, adenylation
                                                                    Name
                                                                    4
                                                                    Type
                                                                    nrps-type1
                                                                    Genes
                                                                    AAM80537.1
                                                                    Substrates
                                                                    4-hydroxyphenylglycine (evidence: Structure-based inference)
                                                                    Integrated Monomers
                                                                    Domains
                                                                    condensation, adenylation, epimerase
                                                                    Name
                                                                    5
                                                                    Type
                                                                    nrps-type1
                                                                    Genes
                                                                    AAM80537.1
                                                                    Substrates
                                                                    4-hydroxyphenylglycine (evidence: Structure-based inference)
                                                                    Integrated Monomers
                                                                    Domains
                                                                    condensation, adenylation, epimerase
                                                                    Name
                                                                    6
                                                                    Type
                                                                    nrps-type1
                                                                    Genes
                                                                    AAM80537.1
                                                                    Substrates
                                                                    tyrosine (evidence: Structure-based inference)
                                                                    Integrated Monomers
                                                                    Domains
                                                                    condensation, adenylation
                                                                    Name
                                                                    7
                                                                    Type
                                                                    nrps-type1
                                                                    Genes
                                                                    AAM80536.1
                                                                    Substrates
                                                                    3,5-dihydroxyphenylglycine (evidence: Structure-based inference)
                                                                    Integrated Monomers
                                                                    Domains
                                                                    condensation, adenylation
                                                                    Annotation changelog

                                                                    Entry version: 4

                                                                    Date
                                                                    Changes
                                                                    Submitters
                                                                    Reviewers
                                                                    2022-10-07
                                                                    Update chemical activity to schema version 2.11
                                                                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                                    Entry version: 3

                                                                    Date
                                                                    Changes
                                                                    Submitters
                                                                    Reviewers
                                                                    2022-09-15
                                                                    Corrected NRP module activity
                                                                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                    2022-09-15
                                                                    Updated bioactivity data
                                                                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                    2022-09-15
                                                                    Updated NRP substrate specificities
                                                                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                                    Entry version: 2

                                                                    Date
                                                                    Changes
                                                                    Submitters
                                                                    Reviewers
                                                                    2019-10-16
                                                                    Migrated from v1.4
                                                                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                    2019-10-16
                                                                    Updated compound(s) information (NPAtlas curation)
                                                                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                                    Entry version: 1

                                                                    Date
                                                                    Changes
                                                                    Submitters
                                                                    Reviewers
                                                                    2015-06-12
                                                                    Submitted
                                                                    • (ID: L2Z4MI3G5WXN6AS52Y55RDTF)
                                                                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
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