BGC0000291: A54145 biosynthetic gene cluster from Streptomyces fradiae
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Location: 1 - 126,933 nt. (total: 126,933 nt).
This entry is originally from NCBI GenBank DQ118863.1.

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
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Gene details
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General
Compounds
Genes
Biosynthesis
History
KnownClusterBlast
NRPS/PKS domains
General information about the BGC

MIBiG accession | BGC0000291
Short description | A54145 biosynthetic gene cluster from Streptomyces fradiae
Status | Quality: questionable The quality level of this entry. Status: active The status of this entry. Completeness: unknown Whether the entry covers everything needed for the pathway producing the compound(s)

Biosynthetic class(es)

- NRPS (Type I)

Loci
DQ118863.1
via
Compounds

- A54145

Species Streptomyces fradiae [taxonomy]
References

- [1] The lipopeptide antibiotic A54145 biosynthetic gene cluster from Streptomyces fradiae. Miao, V et al., Journal of Industrial Microbiology & Biotechnology (2005) DOI:10.1007/s10295-005-0028-5
- [2] The lipopeptide antibiotic A54145 biosynthetic gene cluster from Streptomyces fradiae. Miao V et al., J Ind Microbiol Biotechnol (2006) PMID:16208464

Chemical products information
A54145 Evidence:
(no structure information available)
List of genes involved in compound(s) production

Identifiers | Position | Product | Functions | Evidence | Extra
--- | --- | --- | --- | --- | ---
AAZ23044.1 | <5 - 851 (+) | hypothetical protein |  |  | copy AA seq copy Nt seq
AAZ23045.1 | 848 - 2473 (+) | probable p-aminobenzoyl-glutamate transporter |  |  | copy AA seq copy Nt seq
AAZ23046.1 | 3365 - 4900 (-) | probable histidine ammonia-lyase |  |  | copy AA seq copy Nt seq
AAZ23047.1 | 5048 - 5815 (+) | transcriptional regulator |  |  | copy AA seq copy Nt seq
AAZ23048.1 | 6739 - 7635 (+) | probable hydrolase |  |  | copy AA seq copy Nt seq
AAZ23049.1 | 8966 - 10024 (+) | possible oxidoreductase |  |  | copy AA seq copy Nt seq
AAZ23050.1 | 10027 - 10467 (+) | hypothetical protein |  |  | copy AA seq copy Nt seq
AAZ23051.1 | 11363 - 12862 (-) | probable sugar kinase |  |  | copy AA seq copy Nt seq
AAZ23052.1 | 13059 - 15098 (-) | probable dehydrogenase |  |  | copy AA seq copy Nt seq
AAZ23053.1 | 15190 - 16359 (-) | probable sugar isomerase |  |  | copy AA seq copy Nt seq
AAZ23054.1 | 18507 - 19304 (+) | hypothetical protein |  |  | copy AA seq copy Nt seq
AAZ23055.1 | 19323 - 20366 (-) | hypothetical protein |  |  | copy AA seq copy Nt seq
AAZ23056.1 | 20753 - 21838 (-) | hypothetical protein |  |  | copy AA seq copy Nt seq
AAZ23057.1 | 21918 - 23210 (-) | probable integral membrane protein |  |  | copy AA seq copy Nt seq
AAZ23058.1 | 23207 - 24364 (-) | probable secreted protein |  |  | copy AA seq copy Nt seq
AAZ23059.1 | 24542 - 25225 (-) | probable putative response regulator |  |  | copy AA seq copy Nt seq
AAZ23060.1 | 25222 - 26619 (-) | probable sensor kinase |  |  | copy AA seq copy Nt seq
AAZ23061.1 | 26669 - 28321 (-) | probable D-aminoacylase |  |  | copy AA seq copy Nt seq
AAZ23062.1 | 28359 - 29798 (-) | possible permease |  |  | copy AA seq copy Nt seq
AAZ23063.1 | 29795 - 31207 (-) | probable decarboxylase |  |  | copy AA seq copy Nt seq
AAZ23064.1 | 31333 - 33018 (-) | possible DNA-binding protein |  |  | copy AA seq copy Nt seq
AAZ23065.1 | 33118 - 34419 (-) | hypothetical protein |  |  | copy AA seq copy Nt seq
AAZ23066.1 | 34423 - 35001 (+) | hypothetical protein |  |  | copy AA seq copy Nt seq
AAZ23067.1 | 34950 - 35426 (+) | hypothetical protein |  |  | copy AA seq copy Nt seq
AAZ23068.1 | 35510 - 36931 (-) | hypothetical protein |  |  | copy AA seq copy Nt seq
AAZ23069.1 | 37360 - 38181 (+) | hypothetical protein |  |  | copy AA seq copy Nt seq
AAZ23070.1 | 38233 - 38958 (-) | possible response regulator |  |  | copy AA seq copy Nt seq
AAZ23071.1 | 38955 - 39803 (-) | possible sensor kinase |  |  | copy AA seq copy Nt seq
AAZ23072.1 | 39941 - 40651 (+) | hypothetical protein |  |  | copy AA seq copy Nt seq
AAZ23073.1 | 40648 - 42957 (+) | hypothetical protein |  |  | copy AA seq copy Nt seq
AAZ23074.1 lptEF | 43616 - 45814 (+) | acyl-CoA ligase |  |  | copy AA seq copy Nt seq
AAZ23075.1 lptA | 45924 - 64802 (+) | peptide synthetase |  |  | copy AA seq copy Nt seq
AAZ23076.1 lptB | 64799 - 71230 (+) | peptide synthetase |  |  | copy AA seq copy Nt seq
AAZ23077.1 lptC | 71227 - 86967 (+) | peptide synthetase |  |  | copy AA seq copy Nt seq
AAZ23078.1 lptD | 86967 - 94121 (+) | peptide synthetase |  |  | copy AA seq copy Nt seq
AAZ23079.1 lptG | 94118 - 94360 (+) | hypothetical protein |  |  | copy AA seq copy Nt seq
AAZ23080.1 lptH | 94443 - 95237 (+) | possible thioesterase |  |  | copy AA seq copy Nt seq
AAZ23081.1 lptJ | 95249 - 96244 (+) | hypothetical protein |  |  | copy AA seq copy Nt seq
AAZ23082.1 lptK | 96241 - 97029 (+) | possible O-methyltransferase |  |  | copy AA seq copy Nt seq
AAZ23083.1 lptL | 97099 - 98058 (+) | possible hydrolase |  |  | copy AA seq copy Nt seq
AAZ23084.1 lptM | 98058 - 99119 (+) | possible ABC transporter |  |  | copy AA seq copy Nt seq
AAZ23085.1 lptN | 99116 - 99964 (+) | possible ABC transporter permease |  |  | copy AA seq copy Nt seq
AAZ23086.1 lptP | 100029 - 100649 (-) | hypothetical protein |  |  | copy AA seq copy Nt seq
AAZ23087.1 lptI | 101479 - 102537 (+) | possible methyltransferase |  |  | copy AA seq copy Nt seq
AAZ23088.1 | 104185 - 105123 (+) | possible regulator |  |  | copy AA seq copy Nt seq
AAZ23089.1 | 105287 - 105697 (+) | hypothetical protein |  |  | copy AA seq copy Nt seq
AAZ23090.1 | 105694 - 105879 (-) | hypothetical protein |  |  | copy AA seq copy Nt seq
AAZ23091.1 | 106395 - 107252 (-) | possible transposase |  |  | copy AA seq copy Nt seq
AAZ23092.1 | 110701 - 112812 (-) | possible protein kinase |  |  | copy AA seq copy Nt seq
AAZ23093.1 | 112824 - 113243 (-) | hypothetical protein |  |  | copy AA seq copy Nt seq
AAZ23094.1 | 113931 - 114662 (-) | possible transposase |  |  | copy AA seq copy Nt seq
AAZ23095.1 | 118101 - 119465 (+) | possible DNA helicase |  |  | copy AA seq copy Nt seq
AAZ23096.1 | 118989 - 120017 (-) | hypothetical protein |  |  | copy AA seq copy Nt seq
AAZ23097.1 | 120066 - 120731 (-) | hypothetical protein |  |  | copy AA seq copy Nt seq
AAZ23098.1 | 121573 - 121971 (+) | hypothetical protein |  |  | copy AA seq copy Nt seq
AAZ23099.1 | 122339 - 123214 (-) | probable transposase |  |  | copy AA seq copy Nt seq
AAZ23100.1 | 123359 - 123673 (+) | hypothetical protein |  |  | copy AA seq copy Nt seq
AAZ23101.1 | 123917 - 124387 (+) | possible transposase |  |  | copy AA seq copy Nt seq
AAZ23102.1 | 124378 - 124752 (+) | possible transposase |  |  | copy AA seq copy Nt seq
AAZ23103.1 | 125782 - 126729 (+) | hypothetical protein |  |  | copy AA seq copy Nt seq

Biosynthesis information

#### Biosynthetic modules

Name
Unk01
Type
nrps-type1
Genes
lptA
Substrates
tryptophan (evidence: Structure-based inference [1])
Integrated Monomers
Domains
adenylation
Name
Unk02
Type
nrps-type1
Genes
lptA
Substrates
glutamic acid (evidence: Structure-based inference [1])
Integrated Monomers
Domains
adenylation
Name
Unk03
Type
nrps-type1
Genes
lptA
Substrates
asparagine, 3-hydroxyasparagine (evidence: Structure-based inference, Knock-out studies)
Integrated Monomers
Domains
adenylation
Name
Unk04
Type
nrps-type1
Genes
lptA
Substrates
threonine (evidence: Structure-based inference [1])
Integrated Monomers
Domains
adenylation
Name
Unk05
Type
nrps-type1
Genes
lptA
Substrates
glycine (evidence: Structure-based inference [1])
Integrated Monomers
Domains
adenylation
Name
Unk06
Type
nrps-type1
Genes
lptB
Substrates
alanine (evidence: Structure-based inference [1])
Integrated Monomers
Domains
adenylation
Name
Unk07
Type
nrps-type1
Genes
lptB
Substrates
aspartic acid (evidence: Structure-based inference [1])
Integrated Monomers
Domains
adenylation
Name
Unk08
Type
nrps-type1
Genes
lptC
Substrates
lysine (evidence: Structure-based inference [1])
Integrated Monomers
Domains
adenylation
Name
Unk09
Type
nrps-type1
Genes
lptC
Substrates
aspartic acid, 3-hydroxyaspartic acid, 3-methoxyaspartic acid (evidence: Structure-based inference, Knock-out studies)
Integrated Monomers
Domains
adenylation
Name
Unk10
Type
nrps-type1
Genes
lptC
Substrates
glycine (evidence: Structure-based inference [1])
Integrated Monomers
Domains
adenylation
Name
Unk11
Type
nrps-type1
Genes
lptC
Substrates
asparagine (evidence: Structure-based inference [1])
Integrated Monomers
Domains
adenylation
Name
Unk12
Type
nrps-type1
Genes
lptD
Substrates
3R-methylglutamic acid, glutamic acid (evidence: Structure-based inference, Knock-out studies)
Integrated Monomers
Domains
adenylation
Name
Unk13
Type
nrps-type1
Genes
lptD
Substrates
isoleucine, valine (evidence: Structure-based inference [1])
Integrated Monomers
Domains
adenylation
Annotation changelog

#### Entry version: 4

Date
Changes
Submitters
Reviewers
2022-10-07
Update chemical activity to schema version 2.11

- (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

- (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

#### Entry version: 3

Date
Changes
Submitters
Reviewers
2022-09-15
Updated bioactivity data

- (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

- (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

2022-09-15
Added NRP substrate specificities

- (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

- (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

#### Entry version: 2

Date
Changes
Submitters
Reviewers
2019-10-16
Migrated from v1.4

- (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

- (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

#### Entry version: 1

Date
Changes
Submitters
Reviewers
2015-06-12
Submitted

- (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

- (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

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