BGC0000293 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0000293 (Aspergillus fischeri NRRL 181 (Neosartorya fischeri NRRL 181))

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	indole,NRPS	1	12,765	acetylaszonalenin	NRPS:Type I	100%

BGC0000293 - Region 1 - NRPS,indole

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Location: 1 - 12,765 nt. (total: 12,765 nt) Show pHMM detection rules used

Region on contig edge.

indole: (indsynth or dmat or indole_PTase)
NRPS: cds(Condensation and (AMP-binding or A-OX))

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

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Gene details

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Gene overview

MIBiG

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 12,766
Label		BGC0000293

Detailed domain annotation

Selected features only

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Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000293	2.00	NRP	acetylaszonalenin	Aspergillus fischeri NRRL 181
BGC0002272	0.86	NRP	asterrelenin, epi-aszonalenin A	Aspergillus terreus NIH2624
BGC0000900	0.66	Other	ferrichrome	Aspergillus oryzae
BGC0001249	0.65	NRP	dimethylcoprogen	Alternaria alternata
BGC0002199	0.57	Alkaloid	nanangelenin A	Aspergillus nanangensis
BGC0000357	0.53	NRP	cyclo-(D-Phe-L-Phe-D-Val-L-Val), cyclo-(D-Tyr-L-Phe-D-Val-L-Val), cyclo-(D-Tyr-L-Trp-D-Val-L-Val), cyclo-(D-Phe-L-Trp-D-Val-L-Val), cyclo-(D-Phe-L-Phe-D-Val-L-Ile), cyclo-(D-Phe-L-Phe-D-Ile-L-Val), cyclo-(D-Tyr-L-Trp-D-Val-L-Ile), cyclo-(D-Tyr-L-Trp-D-Ile-L-Val), cyclo-(D-Tyr-L-Phe-D-Val-L-Ile), cyclo-(D-Tyr-L-Phe-D-Ile-L-Val)	Penicillium rubens Wisconsin 54-1255
BGC0001261	0.51	NRP	AM-toxin	Alternaria alternata
BGC0001240	0.50	NRP	serinocyclin A, serinocyclin B	Metarhizium robertsii
BGC0002164	0.50	NRP	peramine	Epichloe festucae
BGC0002166	0.49	NRP	peramine, intermediate 1, intermediate 2	Metarhizium rileyi

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000293	1.00	NRP	acetylaszonalenin	Aspergillus fischeri NRRL 181
BGC0002272	0.74	NRP	asterrelenin, epi-aszonalenin A	Aspergillus terreus NIH2624
BGC0000900	0.66	Other	ferrichrome	Aspergillus oryzae
BGC0001249	0.66	NRP	dimethylcoprogen	Alternaria alternata
BGC0002199	0.62	Alkaloid	nanangelenin A	Aspergillus nanangensis
BGC0000357	0.60	NRP	cyclo-(D-Phe-L-Phe-D-Val-L-Val), cyclo-(D-Tyr-L-Phe-D-Val-L-Val), cyclo-(D-Tyr-L-Trp-D-Val-L-Val), cyclo-(D-Phe-L-Trp-D-Val-L-Val), cyclo-(D-Phe-L-Phe-D-Val-L-Ile), cyclo-(D-Phe-L-Phe-D-Ile-L-Val), cyclo-(D-Tyr-L-Trp-D-Val-L-Ile), cyclo-(D-Tyr-L-Trp-D-Ile-L-Val), cyclo-(D-Tyr-L-Phe-D-Val-L-Ile), cyclo-(D-Tyr-L-Phe-D-Ile-L-Val)	Penicillium rubens Wisconsin 54-1255
BGC0001261	0.59	NRP	AM-toxin	Alternaria alternata
BGC0001240	0.58	NRP	serinocyclin A, serinocyclin B	Metarhizium robertsii
BGC0002164	0.58	NRP	peramine	Epichloe festucae
BGC0002166	0.58	NRP	peramine, intermediate 1, intermediate 2	Metarhizium rileyi

Similar known gene clusters from MIBiG 4.0

Module view

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NRPS/PKS products

NRPS/PKS substrates

Predicted core structure(s)

For candidate cluster 1, location 0 - 12765:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (X - D-Trp)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

NFIA_055290

Search NORINE for peptide: strict or relaxed

AMP-binding (238..633): X

nrpys: Ant

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
Small clusters prediction:: Aliphatic, branched hydrophobic (Val, Leu, Ile, Abu, Ival)
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: GALFFAAGVK
Nearest Stachelhaus code(s):: Ant GALFFAAGVK (100% 8Å match); Trp GALFFAAGVK (91% 8Å match)
Stachelhaus code match:: 100% (strong)

AMP-binding (1320..1709): Trp

nrpys: Trp

SVM prediction details:

Predicted physicochemical class:: N/A
Large clusters prediction:: N/A
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DVMFVGEVAK
Nearest Stachelhaus code(s):: Trp DVMFVGEVAK (100% 8Å match); Ant DVMFVGEVAK (94% 8Å match)
Stachelhaus code match:: 100% (strong)