LOCUS BGC0000295 13141 bp DNA linear BCT 25-APR-2013 DEFINITION Acinetobacter haemolyticus DNA, acinetoferrin biosynthesis gene cluster and transport genes, strain: ATCC 17906. ACCESSION BGC0000295 VERSION BGC0000295 KEYWORDS . SOURCE Acinetobacter haemolyticus ORGANISM Acinetobacter haemolyticus Bacteria; Proteobacteria; Gammaproteobacteria; Moraxellales; Moraxellaceae; Acinetobacter. COMMENT ##antiSMASH-Data-START## Version :: False Run date :: 2022-11-07 18:08:53 NOTE: This is a single region extracted from a larger record! Orig. start :: 0 Orig. end :: 13141 ##antiSMASH-Data-END## FEATURES Location/Qualifiers source 1..13141 /db_xref="taxon:29430" /mol_type="genomic DNA" /note="type strain of Acinetobacter haemolyticus" /organism="Acinetobacter haemolyticus" /strain="ATCC 17906" /type_material="type strain of Acinetobacter haemolyticus" subregion 1..13141 /aStool="mibig" /contig_edge="True" /label="NRP" /subregion_number="1" /tool="antismash" region 1..13141 /contig_edge="True" /product="unknown" /region_number="1" /subregion_numbers="1" /tool="antismash" gene 570..2354 /gene="acbA" CDS 570..2354 /codon_start=1 /gene="acbA" /gene_functions="biosynthetic (rule-based-clusters) siderophore: IucA_IucC" /gene_kind="biosynthetic" /product="putative acinetoferrin biosynthesis protein" /protein_id="BAM09326.1" /sec_met_domain="IucA_IucC (E-value: 7.3e-68, bitscore: 218.1, seeds: 168, tool: rule-based-clusters)" /transl_table=11 /translation="MQSLANRLALQHFVNAYTQETGKGHLLHKSQQSLQLQTFSQGLTL LSIPITSIQARCFFPLSYVSCVGRHRLADLPQIIIDEKIKVFSPVAIVGLLLEELVQEA AVHLDAASLVEKWIQSRDALQQFLQNREYEFDDLVKAGQSFIETEQALILGHSMHPAPK SRTGFVHEDWLNFSPENKGKTQLHYWLVHQDYIAEGSATDEPISAQLKTALQWYLSESD LNLLKTHAEYKLLPLHPWQARYLQGKAWFERLKQTGQLIDLGLRGWQFSPTTSIRTLAS FNAPWMVKPSLSVMITNSIRVNLAKECHRGELTHRLWHSEFGQNILKQCPSLKAVNDPA WIALKIDDEVINESICIFRDQPFHPQQQVTCIASLCQDHPIKPLNRFNALFAKIAKAHP DAEVSEIASDWFNRFLEVSLQPLMYLYHRYGMAFESHQQNVLLELENHFPKTLWLRDNQ GFYYIEEFATEILQALPELKEKAFAVGPKAFVDERFSYYFFGNTLFGIINAIGATGYIT EDELLAHLTGFVEEQLQQYPESTLIQGLLFNSTLPYKGNLLTRLHELDELIAPVENQSV YVQLPNPLRISQKDVSYA" gene 2347..3828 /gene="acbB" CDS 2347..3828 /codon_start=1 /gene="acbB" /gene_functions="biosynthetic-additional (smcogs) SMCOG1080:lysine/ornithine N-monooxygenase (Score: 404.4; E-value: 8.3e-123)" /gene_kind="biosynthetic-additional" /product="putative acinetoferrin biosynthesis protein" /protein_id="BAM09327.1" /transl_table=11 /translation="MLDFIGVGLGPFNLSLASLLQNKSSLNYVFFEQKAQFDWHAGMQL PNTVLQVPFMADLVSMVDPTSPFSFLNYLRHQQRLYKFYFLEQPHIPRCEYNHYCQWVA EQLDCIEYQSQVLKIEPQTIGFKVVVESNGVQQSYLCRHLVVGSGNVPYLPECLAKIQK IRPQQCLHSAQYMTHADTDLHGDVVVLGSGQSAAEVFIDLFDEQQDTVNHQFDLHWFTR SQGFFPMEYAPLGLEHFSPDYAQHFYDLTVQQKEHQLKQQALLYKGISAKTIREIYQKF YHRSIAGQSLQTHLHSQCDLKDAEALDTQKIRLHFQHRATAQSFHLDCDFLVAATGYFT PDFGFMQLLKPYIEFDHKQRWQITDDYRVVHRLNGHIFVQNQEMHSHGVGTPDLGLGAY RAATIINQLLAEPLYELGNQAQTFQHFNLSQNPKICMADDKAQSNECLCENSPNKNHSI FKKTEQNVMTAHPNRRGANTRTQTASVHSTYEKLI" gene 3825..5642 /gene="acbC" CDS 3825..5642 /codon_start=1 /gene="acbC" /gene_functions="biosynthetic (rule-based-clusters) siderophore: IucA_IucC" /gene_kind="biosynthetic" /product="putative acinetoferrin biosynthesis protein" /protein_id="BAM09328.1" /sec_met_domain="IucA_IucC (E-value: 9.3e-66, bitscore: 211.2, seeds: 168, tool: rule-based-clusters)" /transl_table=11 /translation="MNFATLKINQQQWRAAGQRLIEMAIAEFLYEEIIEVKALSAGRYR LDLGNRQYEFQGNQYLLGHWNIQEASVRDVTHSQENDQPAWNLHEFIVAMSDSSNVKPF TKAYLIKEMNNTWLAEAHLFNETRLPSIAVLTEPHYKVEGMLRGHPWLIMSKGRMGFGY DDYLSAAPELSPEVKVLWLAVHRDLAEYRSTEDWSACGLYQHEFDANELQQFINILQEK NLDPQNYFLIPVHAWQWHQWLVPTYANEIVDQKIIELNISQDSYVPMQSIRTLCNTSNL QRHYIKLPVSIFNTAVYRGLPSKRNLAAPAVTAWLKRIHQQDQDLQNTGVIFLGEVATL TIHQPCFDRIDGAPYQFKELFGCLWRESVDRYVDSSHQVLSQAALLHRDISGQSILSVL IQASGLSPLAWLAQFAQVSMSPLLLCLYRYGLAFSPHGENTMLVHENGVPKAMVLKDFI DDINLVDEDFPELAQLPPEAALLLRHEATDLSHFIFTGLFMVHYRYICNVFLQDYPEYS ELDFWQTISNTIVEFNHKHPELAERADKFAMLRPNYTKICLNRVRLFTTSYNDEAERPV PVFLDPIANPVSPETLKTWAQQPRQAKVG" gene 5670..6308 /gene="acbD" CDS 5670..6308 /codon_start=1 /gene="acbD" /gene_functions="biosynthetic-additional (smcogs) SMCOG1203:putative siderophore biosynthesis protein (Score: 173.7; E-value: 1.3e-52)" /gene_kind="biosynthetic-additional" /product="putative acinetoferrin biosynthesis protein" /protein_id="BAM09329.1" /transl_table=11 /translation="MKTISQQLPDYFEYFEDGTQYYLRQVKYPQDIPLLHKWMHEPHVI PQWQLNKSELELQVYFDKMLADDHHRLLIVGIDGKDVGYTEIYEGKRDRLGRYYDGDDN DLGWHLLFGDKSVFGKGFLRPTIRLLSFYIFEHSKAKKIVGEPDHTVKPYAAVVAELCY ESQRLIPMPEKTAMLYYCFRETFYHKFGEYYQTSQQQLADRPAKILSVT" gene 6305..6676 /gene="actB" CDS 6305..6676 /codon_start=1 /gene="actB" /product="hypothetical protein" /protein_id="BAM09330.1" /transl_table=11 /translation="MSLYINEMHILDMRFAAHVSVAEFEQWLARIQHYFEHQRNFVLIM QTDENTEFPEEYRAIQGKWYKQYKQDFYQYCLGFARIAQDDEDRIRLDTPALHKAWHVP YFVSVDKTEAMQWAMQRYL" gene 6673..7908 /gene="actC" CDS 6673..7908 /codon_start=1 /gene="actC" /gene_functions="transport (smcogs) SMCOG1131:major facilitator transporter (Score: 304.5; E-value: 1.4e-92)" /gene_kind="transport" /product="putative ferric acinetoferrin transporter" /protein_id="BAM09331.1" /transl_table=11 /translation="MNQNSLNIQKVSALSLSVVVVLYLAHALPLYFYNVALPAILRHQG VDLRWIGMLSLLYIPWAFKFFWAPLIDRFYLKKLGKRKTWLLFTQIALVLGVVALALTQ FDYGLGVFVIVGLWISTFAATQDIAIDGYTVETFSESEYRLGSMAQSIGVALGSMVGGA ATLWLYQLYGWQTALISLAAMTALTMFAIFQIKEKSISEKIAKHPPSLIRAFKRPEMLW ALALIVCYRFVEAPAMAMLNPMLIDQKWSLAEIGVLMSVIGAGIGLLAAVSAAFLLKKI AATQLLIWAGWARTLIYALLGAAVLLSWFDQWHRLLGVFVVVILAIRYIAMTALYAHFM QTSSKDQAGTDFTILVCFELLVYFIGGAMSGFLAKAFGYGNFYLILAAASILSVLLSQV LISKAKQSKQLI" gene 7918..10176 /gene="actA" CDS 7918..10176 /codon_start=1 /gene="actA" /gene_functions="transport (smcogs) SMCOG1082:TonB-dependent siderophore receptor family (Score: 250.5; E-value: 8.6e-76)" /gene_kind="transport" /product="putative ferric acinetoferrin receptor" /protein_id="BAM09332.1" /transl_table=11 /translation="MKVHTLSTTLTLLSLAVSAQLYAQTTEIDTTIQNNVAAEVQKPTQ LAPIVMTATRSAQSIAEIAGTVQSIEQKQIGQQAAAGRKLADILAQLVPSLSPSSGTTT NYGQTMRGRQVLVLIDGVAQTGSRDAARQLNSISPDSIEKIEVVSGASSIYGSGATGGI INIITKKGTGDGVNFESKLGVTSGDNFKNDALAYEAYQSVGFNQGDWSGFLGAGYTKRG EIQDSHGNRIGPEIAQTDRQDTETVDVNGRLSWQFTDTQKISLGAQYYNDKQDSEYGPD YGPDFAVLKGNPPSLKALKGFEIDDQPFTKRYDVNTQYQNTDLLGQELNIEAYYRNEKA RFYPTVLANFIPAGYYLAYQSESDIDVAGIRAAMTSKLNVADRDLKLTYGIDYDREKDK QTADLYSFTHNGLKYQNTGRSYDFGPDATIKNLGAFVQGNYDLTDALNVQAGIRYQRIE SDTSAFQPTVAAIQGDITGQPVGMVAAGSVKHDKTLFNLGAVYKLNDQQQVFANFSQGF SLPDIQRVLRDVSAGYVVRSGNVDPITVNSYELGWRLQNDLGANLGLTTFYNTSDKVIQ FKADRSVTVADTDQRIYGLEANASMPVLDQFSVGGTLSYTRGQFKDASGSWRELNAFQI SPIKGTLFGEWNDGKGNSLRVQMLAVKGTDKAYEDSLVAKYDENVRPNAATKIKGYAVM DVIANAKAGPGTVGFGVYNVWNADYKTVYGQAAEAVYGPISSLPAQGRTYGLSYTLKY" gene 10231..11457 /gene="actD" CDS 10231..11457 /codon_start=1 /gene="actD" /gene_functions="transport (smcogs) SMCOG1202:major facilitator transporter (Score: 61.5; E-value: 9.1e-19)" /gene_kind="transport" /product="putative acinetoferrin exporter" /protein_id="BAM09333.1" /transl_table=11 /translation="MQQNFKLLAWATLANGTCFSMILPLLAPLIRELGLTEVQGGVIVS AGAICMAIASILIARGEKIQTPYQLMNYGFWGMTITWAIFTAILYWGIQQTLPVMIVFA LLVISRASTGGFMAMPQIGLQSYVMQHVTEEQQRSQKMAMYGAMNSLGMIVGPFLTSVL LFGGILLPMWIAVILLVIFSLIITMYFKHDEGKQNTILDQKQPVKIEHSFSLKPAMPWL ILGFTTYMAIVTLNMTAGFYIQDHFHLSSQQSAIYFSQCMLIVGFSLVITQILIVKVLH LKLKALVLLGTFSMVSGLILSLSAIHIWMFQISYLFYGVGVASLLPAFTTGAAQSVPQT AQVKMASICTATQAIGLIVAPLLSTFLYQFGIQLPFYLLLILMIAVAIYLLIISYSNQN TMISNKVNS" CDS 11775..12332 /codon_start=1 /product="putative IS4 family transposase ORF 1" /protein_id="BAM09334.1" /transl_table=11 /translation="MTHFNELHLILNKYLKWNKSHAKCFTLIMLALIVKQTCNLSSASK ALPIKCLPQSFYRRIQRFFADQYFDYRQISQLIFNIFSFDKVQLTLDRTNWKWGKRDIN ILMLAIVYRGIAIPIVWTLLNKRGNSDTKERIALIQRFISIFGKDRIVNVFADREFIGE KWFTWLIENDINFCIRVKKTLL" CDS 12431..12865 /codon_start=1 /product="putative IS4 family transposase ORF 2" /protein_id="BAM09335.1" /transl_table=11 /translation="MKLYISALRLEDGELLLVVSPMFNASAIRDYALRWEIETLFSCLK GRGFNLENTRLTDPRRVKKLIAVLAIGFCWCYLTGEWQHDRKKAIKIKKHGRLSVSLFR YGLDYVQMAILRLIGFGKKEEFKKVLAILRKKKPDRTRIL" ORIGIN 1 ctgcagttgg ttgtaaaaag ttgcagatgg caaatcccaa agatgctgag cgtttgactg 61 gctatcttgt tggggggatt agccccttgg gtcaaaagaa acgcttaaag actgtgatcg 121 ataaaagtgc acaagcattt gataaaattt acgttagtgg tggaaagcgt gggcttgata 181 ttggactaaa gccgcaagat ttggcaagtt tattaaatgc ttcatttttt gacatattag 241 atttttgatg tggggaaata ttacatttga gactatttaa aaattttata catctataaa 301 aactattgat ggctacaagc tgatcatttt atttaatgag aattattatt atctttttgt 361 atctttactg agcaatatcc cttattaaac aaaataaatt caatgattta gtgctgtttt 421 tctaggttct tttatggaat tgaaatagta aatgataata attatcatta gttccatctt 481 aactacaaac tcccttgtac ttaagatgtg tttcaggcct aaaacatttc gaaaaacaaa 541 ttaactcttt tgaaagagga tatcgacaga tgcaatcact tgctaatcgg ttggcgttac 601 aacatttcgt caatgcatat acgcaagaaa ctggcaaagg tcacttgctt cataaaagtc 661 agcaatctct tcaactacag acgtttagcc aaggtttgac gctgttatca ataccgatta 721 cctctattca agcacgttgc tttttccctt tatcttatgt gagctgtgtg gggcgacatc 781 gcttagcaga tcttccgcaa attattatcg atgaaaaaat taaggtattt agtcctgtag 841 caattgttgg gttgttgcta gaagaacttg ttcaagaagc cgctgttcat ctagatgctg 901 cttcattagt tgaaaaatgg attcaaagtc gagatgcgct acaacagttt ttacaaaatc 961 gtgaatatga atttgatgat ttagtaaaag cagggcaaag ctttattgaa acagagcaag 1021 ctttgatttt agggcatagt atgcatcccg cgccaaaaag taggacaggc tttgttcatg 1081 aagattggtt gaacttttct cctgaaaata aaggtaagac tcaacttcat tattggctag 1141 tgcaccaaga ttatattgca gaaggtagtg cgactgatga acctatttca gcgcaattaa 1201 aaaccgcgtt acagtggtat ttatctgaaa gtgatctcaa tttattaaag acacatgcgg 1261 aatataagtt acttccttta catccatggc aagcgcgtta tttacagggc aaagcttggt 1321 ttgaacgatt aaagcaaaca gggcaactga ttgatttggg cttgcgtggt tggcaattct 1381 ctccaaccac ttccatacgc acattagcga gcttcaatgc accttggatg gtgaagccgt 1441 cactttcagt gatgattacc aattctattc gagtgaattt ggccaaagaa tgtcatcgtg 1501 gtgaattgac acatcgtctg tggcatagtg agtttgggca aaatattctt aaacagtgtc 1561 caagtctaaa agcagtcaat gatccagctt ggatcgcttt aaaaatcgat gatgaagtga 1621 tcaatgaaag tatttgtatt ttccgagatc aaccattcca tccacaacaa caagtcactt 1681 gtatcgcatc tttgtgccaa gatcatccga ttaagccttt aaatcgtttt aatgccttat 1741 ttgcaaaaat tgcgaaagcc catcctgatg ctgaagtttc agagattgct tcagattggt 1801 ttaatcggtt cctcgaagtc agtttgcagc ctttgatgta tctataccat cgttatggta 1861 tggcatttga gtcacatcaa caaaatgtat tattagaact cgaaaaccat tttcctaaaa 1921 ctttatggtt acgtgataac caaggttttt attatattga agaatttgcc actgaaattc 1981 tgcaagcact tcctgaactg aaagaaaaag cctttgcggt aggtccgaaa gcttttgttg 2041 atgaacgttt tagttattat ttctttggca atactttgtt cgggattatt aatgccatcg 2101 gtgcaacagg ctatattact gaagatgaat tgttagcgca tctaactgga tttgtagaag 2161 agcaattaca gcaatatcct gagagtacct taatacaagg actactgttc aattcaacgc 2221 tgccttataa aggcaacttg ctgacacgtt tgcatgaatt agacgagttg atcgcacctg 2281 tagaaaatca atctgtttac gtgcaactgc caaatccgct gcgtatttca cagaaggatg 2341 tcagttatgc ttgattttat tggagttggt ctagggcctt ttaatttaag tcttgctagt 2401 ttgctacaaa acaaaagctc actcaattac gtgttttttg agcaaaaggc gcaatttgat 2461 tggcatgcag gtatgcaact acctaatacg gtattacaag tgccatttat ggcagatttg 2521 gtctcgatgg ttgatccaac cagtccattt agttttttga attatctgcg tcatcagcaa 2581 cgtttgtata agttttactt tttagagcag ccacatattc cacgttgtga atacaaccat 2641 tattgccaat gggttgcaga acaacttgat tgtatcgaat accagtcgca ggttctaaag 2701 attgaacctc aaacgatagg ttttaaagta gtcgttgaat caaacggtgt tcagcaaagt 2761 tatttatgcc gtcatttggt ggttggtagt ggcaatgtgc cttatttgcc tgaatgtttg 2821 gcaaaaattc agaaaatccg tccacaacaa tgtcttcatt cagcacagta tatgacgcat 2881 gccgatacag atttacatgg cgatgtggtc gtacttggtt ctggacaatc tgcagctgaa 2941 gtgtttatcg acttatttga tgaacagcaa gatactgtca atcatcagtt tgatttgcat 3001 tggtttacgc gttctcaggg tttcttcccg atggagtatg cgccattagg tttggaacat 3061 tttagtccag attatgctca gcatttttat gatttgactg tgcagcaaaa ggaacatcag 3121 ttaaagcaac aagccttgtt atacaaggga attagcgcaa aaaccattcg tgaaatttat 3181 cagaaatttt atcaccgcag tattgcaggt caaagcttac agacacattt acatagtcaa 3241 tgtgatttga aagatgcaga agcattggat acacaaaaaa tccgactgca tttccagcat 3301 cgtgctacag ctcagtcttt tcatctcgac tgtgattttc ttgtagccgc gacgggttat 3361 ttcacgcctg attttggttt tatgcagttg ctcaagccat acatagagtt tgatcataaa 3421 cagcgttggc agattacaga cgactatcgt gttgtacatc ggctgaatgg tcatattttt 3481 gttcaaaatc aggaaatgca tagtcatggt gtcggcacac ctgatttagg tcttggtgct 3541 tatcgtgcag caacgatcat taatcaattg cttgctgagc ctctttatga attaggcaat 3601 caagcgcaga cattccaaca ctttaatctc tctcaaaatc caaaaatttg tatggcagat 3661 gacaaagcac aatcaaacga gtgcctttgc gaaaattctc ccaataaaaa ccattcaatt 3721 ttcaagaaaa cagaacagaa cgtgatgacg gcgcatccta atcgtcgtgg tgcaaacact 3781 cgtacacaaa ctgcttctgt acattcaaca tatgagaaac tgatatgaac tttgcaactt 3841 taaaaattaa tcagcagcaa tggcgtgccg caggacaacg tcttattgaa atggcgattg 3901 cagagtttct atacgaagaa attattgaag ttaaagcatt gtcagcaggg cgttatcgtt 3961 tagatttagg caatcgtcag tatgagtttc aaggaaatca atatctactc ggacactgga 4021 atattcagga agcttcggta cgcgatgtga ctcatagtca ggaaaatgat caacctgctt 4081 ggaacttaca tgagttcatt gtcgcaatgt ctgacagttc taatgttaag ccatttacca 4141 aagcgtattt gatcaaagaa atgaataata cttggcttgc agaagcacat ttgttcaatg 4201 aaacacgttt gccaagtata gcggttttga cagagccaca ttacaaagtt gaaggcatgc 4261 tacgtggtca tccctggctc atcatgagta aagggcgtat gggttttggt tatgatgatt 4321 atttaagcgc tgcaccagag ctttcacctg aagttaaagt attgtggtta gccgtacatc 4381 gtgatttggc agagtatcga agtactgaag attggagtgc ctgcggttta tatcaacatg 4441 aatttgatgc caatgaacta cagcaattca tcaatattct ccaagaaaaa aatctagacc 4501 cgcaaaatta ctttttaatt ccagtacacg catggcaatg gcatcaatgg ctcgttccga 4561 cttatgccaa tgagattgtc gatcagaaaa tcattgagct gaatatcagc caagatagct 4621 atgtgccgat gcaatcaatc cgcacattat gcaatacgtc aaacctacaa cgccattaca 4681 ttaagttgcc tgtcagtatt tttaataccg ctgtttatcg tggattaccc tcaaagcgta 4741 atctagcagc tccagcagtg accgcatggt taaaaagaat tcatcaacaa gatcaagact 4801 tacaaaatac aggtgtgatt ttcttaggtg aagttgcgac tttaactatc catcagcctt 4861 gtttcgatcg cattgatggc gcaccgtatc aatttaaaga gctgttcggt tgtttatggc 4921 gtgaaagtgt tgatcgttat gttgattcat ctcatcaagt gttatctcaa gcagcattgt 4981 tacaccgtga tatttcaggt caatcgatct tgagcgtgtt gatccaggca tcaggtttaa 5041 gccctttggc ttggttagca caatttgctc aagtaagtat gagtccatta ttactttgct 5101 tataccgcta tggtttggca ttttcaccac acggtgagaa cacgatgttg gtacatgaaa 5161 atggagtacc aaaagctatg gtattaaaag atttcattga tgacattaat ttggtggatg 5221 aggatttccc tgagttagct cagttaccac ctgaagcggc tttgttatta cgacatgagg 5281 cgaccgatct aagtcatttt atcttcactg gtctgttcat ggttcattac cgctatatct 5341 gtaatgtgtt cttgcaagac tatcctgaat attctgagct tgatttctgg cagaccattt 5401 ccaacacaat tgttgaattt aaccacaaac atccagaact ggctgaacgt gctgataaat 5461 tcgccatgct gcgtcctaac tacaccaaaa tttgcctaaa ccgtgtacgt ctatttacca 5521 caagttataa cgatgaagca gagcgtcctg tgcctgtctt tcttgatccc attgcaaatc 5581 cagttagccc agaaacattg aaaacgtggg cacagcaacc tcgccaagcg aaagtgggct 5641 aattttattc gtcattttat aggttcgata tgaaaacaat ctctcagcaa ttaccagatt 5701 attttgaata ctttgaagat ggaactcagt actacttacg acaagtgaaa tatccgcagg 5761 atattccttt attgcacaaa tggatgcatg aaccacatgt gattccacag tggcagctaa 5821 ataaatcgga actggagtta caagtttact tcgacaaaat gcttgcagat gaccatcacc 5881 gtttattgat cgtcggaatt gatggcaaag atgtgggcta taccgaaatt tatgagggta 5941 aacgagatcg tttaggccgt tattacgatg gtgatgacaa tgatctcggt tggcatttgc 6001 tatttggtga caaatcagtg ttcggtaaag gttttttacg cccaactatt cgtttactca 6061 gcttctatat ttttgagcac tctaaagcga aaaaaattgt gggtgagcca gatcataccg 6121 tcaaacctta tgcagcagtg gtggcagagc tttgttatga aagccaacgt ttaataccga 6181 tgcctgaaaa aacagcgatg ttgtactact gctttagaga aactttttat cacaagtttg 6241 gggaatatta ccaaacatca caacaacagc tagcagatcg gccagccaaa atcctgagtg 6301 ttacatgagc ttatatatca atgaaatgca tatcctagac atgcgctttg cagcgcatgt 6361 ctcggtagca gaatttgaac aatggttagc acgaattcag cactatttcg aacatcagcg 6421 aaattttgtg ttgatcatgc aaactgatga aaatacagaa tttccggagg aatatagagc 6481 aatccaaggc aagtggtata aacaatataa acaagatttt taccaatatt gcttaggttt 6541 tgcgcgtatt gctcaggatg acgaagatcg tattcgattg gatacaccag cactacacaa 6601 agcttggcac gtcccatatt ttgtcagcgt agataaaact gaagccatgc aatgggcgat 6661 gcagaggtat ttatgaatca aaattcatta aatattcaga aagtttcagc cttaagccta 6721 agtgtcgtgg tggttttata cctcgcgcat gctttaccac tgtattttta caacgtggca 6781 ttaccagcga ttctgcgcca tcaaggtgta gatttacgtt ggattggcat gttgtcgttg 6841 ctttatattc cttgggcatt caaattcttt tgggcgcctt taattgatcg tttctactta 6901 aaaaaactag gaaagcgtaa gacttggttg ctatttacac aaattgcact ggtgctaggt 6961 gttgttgctt tggcattaac acagtttgat tatggcctcg gtgtatttgt cattgttggt 7021 ttatggattt caacttttgc agcaactcaa gatattgcca ttgatggcta taccgtcgaa 7081 accttttcag agtctgaata tcgcttagga agcatggcac aaagcatcgg cgttgcgctc 7141 ggtagtatgg tgggtggagc agcaacttta tggctttacc agctttatgg ctggcaaact 7201 gcattgattt ccttagccgc aatgacggca ctgactatgt ttgcgatttt ccaaatcaaa 7261 gaaaaatcaa tttctgagaa aatcgctaaa catccaccaa gtctgattcg tgcgtttaaa 7321 cgtccagaaa tgttatgggc tttagctttg atcgtgtgtt atcgcttcgt tgaagcacct 7381 gcaatggcaa tgctgaatcc gatgctaatt gatcaaaagt ggtctttggc agagattgga 7441 gtgttgatgt ctgtgatcgg tgcgggtatt ggattattag ctgctgtatc tgctgcattt 7501 ctcttgaaaa aaatagcagc tacacaatta ctgatctggg caggctgggc acgtactttg 7561 atttatgcct tgttgggtgc agctgttcta ctcagttggt ttgatcaatg gcacagatta 7621 cttggtgtat ttgtagttgt cattcttgca attcgttata tcgcgatgac ggcgttatat 7681 gcacatttca tgcagaccag ctctaaagat caagcaggaa cggattttac gattttggtc 7741 tgttttgaat tattggttta tttcattggt ggtgcgatgt caggtttctt agctaaagcg 7801 tttggctatg gaaattttta tttaattctc gccgctgcat ccattttaag cgttttactc 7861 agtcaagttt tgatttctaa agcaaaacaa tcgaaacaac ttatctaggg gctacttatg 7921 aaagttcata cactttcgac aacactaaca cttctaagct tggcagtaag tgcccagctt 7981 tatgctcaaa caactgagat cgataccacg attcaaaata atgttgcagc agaagtccaa 8041 aaaccaacac aacttgcgcc aattgttatg acagcaactc gttcagcaca aagtatcgct 8101 gaaattgcag ggacagttca atcaatcgaa cagaaacaaa ttggacaaca agcggcggct 8161 ggacgaaagt tggcagatat tctagctcaa ctggttccat cactcagccc gagtagcgga 8221 acaaccacta attacggtca aactatgcgt ggccgtcagg tgcttgtcct tattgatggg 8281 gttgcccaaa caggttcacg tgatgccgca cgccaactaa atagtattag ccctgattca 8341 attgaaaaaa ttgaggtggt ttcaggtgca agtagtatct acggttccgg tgcaacaggc 8401 ggtattatta atatcatcac aaagaaaggg actggtgatg gtgtaaattt tgaatcaaaa 8461 cttggtgtta catctggcga taattttaaa aatgatgcac tagcttatga agcttatcaa 8521 tcagttgggt ttaatcaagg tgattggagt ggtttcttag gggcaggcta taccaaacgt 8581 ggtgaaatcc aagacagtca tggtaatcgc attggaccag agattgcaca aacggatcgc 8641 caagatacag aaacggttga tgtgaatggt cgtttaagct ggcaatttac tgatacccaa 8701 aaaataagtt tgggggctca gtattataat gacaaacaag attcagagta tggtccagat 8761 tatggtccag acttcgcagt tttaaaaggc aatccaccga gtttaaaagc actcaaaggt 8821 tttgaaatcg atgatcagcc attcaccaaa cgttatgatg taaatacgca atatcaaaac 8881 acggatttac ttgggcaaga gctgaatata gaagcatatt atcgcaatga aaaagcgcgc 8941 ttttacccga cggttttagc taactttatt cctgctggat attatttggc ttaccaatct 9001 gagtctgata ttgatgttgc cggtattcgt gctgcaatga catcaaagtt gaatgttgct 9061 gatcgtgatc taaaactgac ttatggtatt gattatgacc gtgagaaaga taagcaaaca 9121 gctgatttat atagttttac ccacaatggt ctgaaatatc aaaatacagg gcggagttat 9181 gactttggcc cagatgcaac cattaaaaac ttaggtgcat ttgttcaagg aaattatgat 9241 ttaacggatg cattgaatgt tcaagcgggc attcgttatc aacgtattga aagcgacacc 9301 agtgcatttc aacccactgt tgcagctatt caaggtgata tcaccggaca gccggttgga 9361 atggtcgctg caggttctgt taaacacgac aaaacattat ttaatttagg cgctgtgtac 9421 aaattaaatg accagcaaca agtatttgca aacttctctc aaggttttag cttaccagat 9481 attcaacgtg tattacgcga tgtttctgct ggttatgtag ttcgatcagg caatgttgat 9541 ccaattactg tcaatagtta cgaattgggt tggagattgc aaaatgacct tggtgcaaat 9601 cttggattaa caacgttcta caatacttct gataaagtca tccagtttaa agctgatcgt 9661 tctgtaactg ttgcagatac agaccaacgt atttatggtc ttgaagcgaa tgcaagcatg 9721 ccagtattgg atcaatttag tgtcggtggg acattatctt atactcgagg tcaatttaaa 9781 gacgcgagtg gttcttggcg agagctgaac gcttttcaaa tttccccaat caaaggaaca 9841 ttattcggtg agtggaatga tggcaagggc aatagtctaa gagttcagat gcttgccgtg 9901 aaaggtactg ataaagcata tgaagattcc ctcgttgcca aatatgatga aaatgttcgc 9961 ccaaatgcgg caactaaaat caaggggtat gcagtcatgg atgtgattgc caatgccaaa 10021 gcaggtcctg gaactgtagg ttttggtgtc tataatgttt ggaatgcaga ctataaaacg 10081 gtatatggcc aagcggctga agcagtttat ggtccaattt ctagtctacc agctcaaggt 10141 cgtacctacg gtctaagcta tacacttaaa tactaatcca atcataaagg catctgatta 10201 agatgccttt tcttttgatg aatactacct atgcaacaaa attttaaatt attggcttgg 10261 gcaactctag ccaacggtac ttgtttttca atgattttac ctttacttgc cccattaatt 10321 cgtgagcttg gcttaacaga agtacagggc ggagtaattg tttcagcggg tgcaatttgt 10381 atggcgattg catctattct gattgcccga ggggaaaaaa tacagactcc ttatcaatta 10441 atgaattatg gtttctgggg catgaccatt acttgggcta tatttacagc gattctttat 10501 tggggaatac aacaaacatt acccgtaatg atagtttttg ctttgttggt gattagtcga 10561 gcgagtactg gtggttttat ggctatgcca caaattggtc tacaaagtta tgtcatgcaa 10621 catgtcacag aggaacaaca acgcagtcaa aaaatggcaa tgtatggtgc gatgaatagc 10681 ttaggtatga tcgtcggtcc atttctgacg tccgtgttat tgtttggtgg cattctattg 10741 ccaatgtgga ttgctgttat tttgttagtg atttttagtt tgattatcac aatgtatttt 10801 aaacatgatg agggtaaaca aaacacaata ttggatcaaa aacagcctgt aaaaatagag 10861 cattcatttt cattaaaacc agctatgcct tggcttattt taggatttac tacctatatg 10921 gctatcgtga cgctcaatat gactgcagga ttctatattc aagaccattt tcatttaagc 10981 tcacaacaaa gtgcgattta tttttcccaa tgtatgctca ttgttggttt tagcttagtg 11041 attactcaga tcctgattgt aaaagtactt catttaaaac taaaagcttt ggtattgctg 11101 ggtacgttta gcatggttag tggacttatc ctatctttaa gtgcaatcca tatttggatg 11161 tttcaaataa gttatttatt ttatggggtc ggggtggcaa gccttttgcc tgcatttacc 11221 acaggggcgg ctcaatctgt tccgcaaact gctcaagtca aaatggcaag tatttgtaca 11281 gctactcaag cgattggtct cattgtggcg cctttactga gcacttttct atatcagttc 11341 ggcattcaat taccttttta tttactctta atattgatga ttgctgtggc gatctacttg 11401 ttgatcatat cctattcaaa tcagaatacg atgataagca ataaggttaa ctcctaaatc 11461 aaatatgctt gaaagacaga gaatattaaa tttttatgat tgcagtctcg taatcaattc 11521 ttagatgatt atttttagtt ggacgtttga tctaggcgta tggatattca ttctgcagtt 11581 tattcacatt ttctatccaa ggggacttac taagacagaa aaacataaaa acccatatat 11641 aaaaaatgtc aatcacaata cctttcataa tgcaaatttt ttgaccaata ctataggtat 11701 tcgctttgta cacgacaaaa aaagataact cattgaaata atggcataat acttgttttc 11761 tgacgacgaa tatgatgaca catttcaatg agttacatct catcttaaac aaatatctaa 11821 agtggaacaa gtcacatgca aaatgtttta cactgattat gcttgcatta attgtaaaac 11881 agacatgtaa tctttcttct gcatctaaag ccttacccat caagtgctta ccacaatcat 11941 tttatcgacg tatacaacgc ttctttgcag atcagtattt cgattatcgt caaatttctc 12001 agttaatttt caatatattt tcattcgata aagtccaatt aactttggat agaactaatt 12061 ggaaatgggg aaaacgagat attaatatct tgatgttagc catcgtctat cgtggaatag 12121 cgatacctat tgtttggaca ttgctcaata aacgtggaaa ttcagataca aaagagcgta 12181 ttgctttgat tcaacgcttt atctccattt ttggtaaaga tcgtattgtg aatgtgtttg 12241 cagacagaga atttatcggt gagaaatggt ttacatggtt aattgaaaat gacattaact 12301 tctgtatacg tgttaaaaaa actttattgt gaccaatcac ttagccaaga atcataaaat 12361 tagtgattta tttcgtcatc ttcaagttgg tcaaactgaa tgtcgtaaac gacgtatttg 12421 ggttggtcga gtgaaactgt atattagtgc gctacgatta gaagatggag agcttttact 12481 tgttgtttct cctatgttta atgcttctgc tattcgtgat tatgcattac gctgggaaat 12541 cgaaacgtta tttagttgtc tcaaaggacg tggattcaat cttgaaaata ctcgtttaac 12601 agaccctaga cgagtcaaga aattgatagc agtgctagct atcggtttct gttggtgcta 12661 tttaacaggt gaatggcaac atgatcggaa aaaagcgata aaaataaaga agcatggacg 12721 actttcagta agtttatttc gctacggttt ggactatgtt caaatggcta ttctacgttt 12781 gattggtttt ggaaaaaaag aagaatttaa gaaagtgcta gcaattttaa gaaagaaaaa 12841 gcctgatagg acaaggatcc tatgaaattt gtcgtgtaca gagaggtatt cgataaatat 12901 tttaaatgca tggttaaaat ttaatcattt ttatttcatt tatttacaac ttggattatc 12961 acaaatttta ttcggtatgc taaaagatcg tgataacaat caaggagtaa taatgctgat 13021 ttttcatgat tatcctgtcc atggggcgat ctttgatatg gatggcacaa tgtttgatac 13081 tgagcgatta cgctttcaaa cattaaaaca agcctctcaa gaactcattg gacaggaatt 13141 c //