BGC0000296: actinomycin D biosynthetic gene cluster from Streptomyces anulatus
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Location: 1 - 66,086 nt. (total: 66,086 nt).
This entry is originally from NCBI GenBank HM038106.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
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Gene details
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General
Compounds
Genes
NRP
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0000296
Short description actinomycin D biosynthetic gene cluster from Streptomyces anulatus
Status Minimal annotation: no
A minimal annotation only contains information on the BGC loci and one or more linked chemical product(s)

Completeness: Unknown
Whether the loci encodes everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRP
Loci NCBI GenBank: HM038106.1
Compounds
  • actinomycin D
Species Streptomyces anulatus [taxonomy]
References
Chemical products information
actinomycin D
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C62H86N12O16
Chemical database entries
NPAtlas
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • ADG27345.1
  • acmrC
 936 - 3206 (-) UrvA-like protein
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  • ADG27346.1
  • acmrB
 3293 - 4060 (-) ABC 2-type transporter
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  • ADG27347.1
  • acmrA
 4050 - 5033 (-) ABC transporter ATPase subunit
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  • ADG27348.1
  • acmQ
 5113 - 5997 (-) siderophore-interacting protein
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  • ADG27349.1
  • acmP
 6112 - 6954 (+) TetR family transcriptional regulator
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  • ADG27350.1
  • acmO
 7181 - 7828 (+) LbmU-like protein
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  • ADG27351.1
  • acmL
 9455 - 10495 (-) methyltransferase
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  • ADG27352.1
  • acmK
 10548 - 11447 (-) kynureninase
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  • ADG27353.1
  • acmT
 11598 - 12233 (-) hypothetical protein
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  • ADG27354.1
  • acmS
 12244 - 12804 (-) unknown
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  • ADG27355.1
  • acmR
 12817 - 13017 (-) MbtH-like protein
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  • ADG27356.1
  • acmD
 13084 - 13320 (-) 4-MHA carrier protein
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  • ADG27357.1
  • acmA
 13317 - 14735 (-) peptide synthetase
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  • ADG27358.1
  • acmB
 15166 - 23001 (+) peptide synthetase
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  • ADG27359.1
  • acmC
 22998 - 35741 (+) peptide synthetase
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  • ADG27360.1
  • acmE
 35738 - 36445 (+) hypothetical protein
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  • ADG27361.1
  • acmF
 36480 - 37394 (+) aryl formamidase
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  • ADG27362.1
  • acmG
 37391 - 38233 (+) tryptophan 2,3-dioxygenase
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  • ADG27363.1
  • acmH
 38294 - 39556 (+) kynureninase
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  • ADG27364.1
  • acmI
 39628 - 40668 (+) methyltransferase
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  • ADG27365.1
  • acmJ
 40804 - 41439 (-) LbmU-like protein
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  • ADG27366.1
  • acmU
 41560 - 42450 (-) TetR family transcriptional regulator
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  • ADG27367.1
  • acmV
 42565 - 43461 (+) siderophore-interacting protein
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  • ADG27368.1
  • acmW
 43561 - 44544 (+) ABC transporter ATPase subunit
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  • ADG27369.1
  • acmX
 44534 - 45301 (+) ABC 2-type transporter
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  • ADG27370.1
  • orf120
 47456 - 47818 (-) transposase
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  • ADG27371.1
  • orf157
 47962 - 48435 (-) transposase
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  • ADG27372.1
  • orf238
 49372 - 50088 (+) transposase
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NRP-specific information
Subclass N/A
Cyclic? no
NRP-synthases
Gene Modules
acmB
Module ?
Specificity: threonine
Evidence for specificity:
Module ?
Specificity: valine
Evidence for specificity:
acmC
Module ?
Specificity: proline
Evidence for specificity:
Module ?
Specificity: glycine
Evidence for specificity:
Module ?
Specificity: valine
Evidence for specificity:
Annotation changelog
MIBiG version Submitter Notes
1.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Submitted
2.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Migrated from v1.4
  • Updated compound(s) information (NPAtlas curation)
3.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Updated bioactivity data
  • Added NRP substrate specificities
3.1
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Update chemical activity to schema version 2.11
Detailed domain annotation
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