BGC0000296: actinomycin D biosynthetic gene cluster from Streptomyces anulatus
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
View antiSMASH-generated output
Download Cluster GenBank file
Download region SVG
Location: 1 - 66,086 nt. (total: 66,086 nt).
This entry is originally from NCBI GenBank HM038106.1.

Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
reset zoomreset view
zoomzoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
General
Compounds
Genes
Biosynthesis
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0000296
Short description actinomycin D biosynthetic gene cluster from Streptomyces anulatus
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: unknown
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRPS (Type I)
Loci
HM038106.1
via
Compounds
  • actinomycin D
Species Streptomyces anulatus [taxonomy]
References
Chemical products information
actinomycin D Evidence:
Copy SMILES
C62H86N12O16
Chemical database entries
NPAtlas
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • ADG27345.1
  • acmrC
 936 - 3206 (-) UrvA-like protein
    copy AA seq
    copy Nt seq
    • ADG27346.1
    • acmrB
    		 3293 - 4060 (-) ABC 2-type transporter
      copy AA seq
      copy Nt seq
      • ADG27347.1
      • acmrA
      		 4050 - 5033 (-) ABC transporter ATPase subunit
        copy AA seq
        copy Nt seq
        • ADG27348.1
        • acmQ
        		 5113 - 5997 (-) siderophore-interacting protein
          copy AA seq
          copy Nt seq
          • ADG27349.1
          • acmP
          		 6112 - 6954 (+) TetR family transcriptional regulator
            copy AA seq
            copy Nt seq
            • ADG27350.1
            • acmO
            		 7181 - 7828 (+) LbmU-like protein
              copy AA seq
              copy Nt seq
              • ADG27351.1
              • acmL
              		 9455 - 10495 (-) methyltransferase
                copy AA seq
                copy Nt seq
                • ADG27352.1
                • acmK
                		 10548 - 11447 (-) kynureninase
                  copy AA seq
                  copy Nt seq
                  • ADG27353.1
                  • acmT
                  		 11598 - 12233 (-) hypothetical protein
                    copy AA seq
                    copy Nt seq
                    • ADG27354.1
                    • acmS
                    		 12244 - 12804 (-) unknown
                      copy AA seq
                      copy Nt seq
                      • ADG27355.1
                      • acmR
                      		 12817 - 13017 (-) MbtH-like protein
                        copy AA seq
                        copy Nt seq
                        • ADG27356.1
                        • acmD
                        		 13084 - 13320 (-) 4-MHA carrier protein
                          copy AA seq
                          copy Nt seq
                          • ADG27357.1
                          • acmA
                          		 13317 - 14735 (-) peptide synthetase
                            copy AA seq
                            copy Nt seq
                            • ADG27358.1
                            • acmB
                            		 15166 - 23001 (+) peptide synthetase
                              copy AA seq
                              copy Nt seq
                              • ADG27359.1
                              • acmC
                              		 22998 - 35741 (+) peptide synthetase
                                copy AA seq
                                copy Nt seq
                                • ADG27360.1
                                • acmE
                                		 35738 - 36445 (+) hypothetical protein
                                  copy AA seq
                                  copy Nt seq
                                  • ADG27361.1
                                  • acmF
                                  		 36480 - 37394 (+) aryl formamidase
                                    copy AA seq
                                    copy Nt seq
                                    • ADG27362.1
                                    • acmG
                                    		 37391 - 38233 (+) tryptophan 2,3-dioxygenase
                                      copy AA seq
                                      copy Nt seq
                                      • ADG27363.1
                                      • acmH
                                      		 38294 - 39556 (+) kynureninase
                                        copy AA seq
                                        copy Nt seq
                                        • ADG27364.1
                                        • acmI
                                        		 39628 - 40668 (+) methyltransferase
                                          copy AA seq
                                          copy Nt seq
                                          • ADG27365.1
                                          • acmJ
                                          		 40804 - 41439 (-) LbmU-like protein
                                            copy AA seq
                                            copy Nt seq
                                            • ADG27366.1
                                            • acmU
                                            		 41560 - 42450 (-) TetR family transcriptional regulator
                                              copy AA seq
                                              copy Nt seq
                                              • ADG27367.1
                                              • acmV
                                              		 42565 - 43461 (+) siderophore-interacting protein
                                                copy AA seq
                                                copy Nt seq
                                                • ADG27368.1
                                                • acmW
                                                		 43561 - 44544 (+) ABC transporter ATPase subunit
                                                  copy AA seq
                                                  copy Nt seq
                                                  • ADG27369.1
                                                  • acmX
                                                  		 44534 - 45301 (+) ABC 2-type transporter
                                                    copy AA seq
                                                    copy Nt seq
                                                    • ADG27370.1
                                                    • orf120
                                                    		 47456 - 47818 (-) transposase
                                                      copy AA seq
                                                      copy Nt seq
                                                      • ADG27371.1
                                                      • orf157
                                                      		 47962 - 48435 (-) transposase
                                                        copy AA seq
                                                        copy Nt seq
                                                        • ADG27372.1
                                                        • orf238
                                                        		 49372 - 50088 (+) transposase
                                                          copy AA seq
                                                          copy Nt seq
                                                          Biosynthesis information

                                                          Biosynthetic modules

                                                          Name
                                                          Unk01
                                                          Type
                                                          nrps-type1
                                                          Genes
                                                          acmB
                                                          Substrates
                                                          threonine (evidence: )
                                                          Integrated Monomers
                                                          Domains
                                                          adenylation
                                                          Name
                                                          Unk02
                                                          Type
                                                          nrps-type1
                                                          Genes
                                                          acmB
                                                          Substrates
                                                          valine (evidence: )
                                                          Integrated Monomers
                                                          Domains
                                                          adenylation
                                                          Name
                                                          Unk03
                                                          Type
                                                          nrps-type1
                                                          Genes
                                                          acmC
                                                          Substrates
                                                          proline (evidence: )
                                                          Integrated Monomers
                                                          Domains
                                                          adenylation
                                                          Name
                                                          Unk04
                                                          Type
                                                          nrps-type1
                                                          Genes
                                                          acmC
                                                          Substrates
                                                          glycine (evidence: )
                                                          Integrated Monomers
                                                          Domains
                                                          adenylation
                                                          Name
                                                          Unk05
                                                          Type
                                                          nrps-type1
                                                          Genes
                                                          acmC
                                                          Substrates
                                                          valine (evidence: )
                                                          Integrated Monomers
                                                          Domains
                                                          adenylation
                                                          Annotation changelog

                                                          Entry version: 4

                                                          Date
                                                          Changes
                                                          Submitters
                                                          Reviewers
                                                          2022-10-07
                                                          Update chemical activity to schema version 2.11
                                                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                          Entry version: 3

                                                          Date
                                                          Changes
                                                          Submitters
                                                          Reviewers
                                                          2022-09-15
                                                          Updated bioactivity data
                                                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                          2022-09-15
                                                          Added NRP substrate specificities
                                                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                          Entry version: 2

                                                          Date
                                                          Changes
                                                          Submitters
                                                          Reviewers
                                                          2019-10-16
                                                          Migrated from v1.4
                                                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                          2019-10-16
                                                          Updated compound(s) information (NPAtlas curation)
                                                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                          Entry version: 1

                                                          Date
                                                          Changes
                                                          Submitters
                                                          Reviewers
                                                          2015-06-12
                                                          Submitted
                                                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                          Detailed domain annotation
                                                          Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
                                                          A domain glossary is available here, and an explanation of the visualisation is available here.
                                                          Selected features only
                                                          Show module domains
                                                          Similar known gene clusters from MIBiG 4.0
                                                          Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
                                                          Click on reference genes to show details of similarities to genes within the current region.
                                                          Click on an accession to open that entry in the MiBIG database.