Genomic loci for this biosynthetic pathway

Cluster Type From To
The following clusters are from record BGC0000296.1:
Cluster 1NRP166086

BGC0000296, actinomycin biosynthetic gene cluster from Streptomyces anulatus. Locus 1. Partial MIBiG entry.

Chemical compounds

Compound: actinomycin
PubChem ID: 2019
SMILES string: Copy to clipboard
Molecular formula: C62H86N12O16
Average molecular mass: 1255.438 Da

Class-specific details

Biosynthetic class(es):

Gene cluster description

actinomycin (BGC0000296). Gene Cluster 1. Biosynthetic class = NRP. GenBank HM038106. Click on genes for more information.


biosynthetic genes
transport-related genes
regulatory genes
other genes

Domain annotation

Homologous known gene clusters

Literature references

1. Pfennig F et al. (1999) Molecular characterization of the genes of actinomycin synthetase I and of a 4-methyl-3-hydroxyanthranilic acid carrier protein involved in the assembly of the acylpeptide chain of actinomycin in Streptomyces. J Biol Chem 274(18):12508-16.
2. Schauwecker F et al. (2000) Construction and in vitro analysis of a new bi-modular polypeptide synthetase for synthesis of N-methylated acyl peptides. Chem Biol 7(4):287-97.
3. Keller U et al. (2010) The actinomycin biosynthetic gene cluster of Streptomyces chrysomallus: a genetic hall of mirrors for synthesis of a molecule with mirror symmetry. J Bacteriol 192(10):2583-95. doi: 10.1128/JB.01526-09. Epub 2010 Mar