BGC0000297: aeruginoside 126B biosynthetic gene cluster from Planktothrix agardhii NIVA-CYA 126
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Location: 1 - 31,449 nt. (total: 31,449 nt).
This entry is originally from NCBI GenBank AM071396.2.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
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Gene details
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General
Compounds
Genes
Biosynthesis
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0000297
Short description aeruginoside 126B biosynthetic gene cluster from Planktothrix agardhii NIVA-CYA 126
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: complete
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRPS (Type I)
  • PKS (Unknown)
  • saccharide (hybrid/tailoring)
Loci
AM071396.2
via Knock-out studies, Enzymatic assays
Compounds
  • aeruginoside 126B
  • aeruginoside 126A
Species Planktothrix agardhii NIVA-CYA 126 [taxonomy]
References
Chemical products information
aeruginoside 126B Evidence:
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C34H54N6O9
Chemical database entries
NPAtlas
aeruginoside 126A Evidence:
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C36H54N6O9
Chemical database entries
NPAtlas
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • CAM59600.1
  • ORF2
 1264 - 2010 (-) hypothetical protein
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    • CAM59601.1
    • aerA
    		 2649 - 6899 (+) non-ribosomal peptide synthetase/polyketide synthase hybrid enzyme
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      • CAJ21198.2
      • aerB
      		 7116 - 11912 (+) non-ribosomal peptide synthetase
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        • CAM59602.1
        • ORF3
        		 11949 - 12815 (+) hypothetical protein
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          • CAJ21199.2
          • aerC
          		 12856 - 15066 (+) putative oxygenase
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            • CAM59603.1
            • aerD
            		 15167 - 15775 (+) Prephenate decarboxylase
            • Precursor biosynthesis
            • Knock-out Activity assay
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            • CAM59604.1
            • aerE
            		 15822 - 16463 (+) hypothetical protein
            • Precursor biosynthesis
            • Knock-out
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            • CAM59605.1
            • aerF
            		 16492 - 17286 (+) putative reductase
            • Precursor biosynthesis
            • Knock-out
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            • CAM59606.1
            • aerG
            		 17416 - 22284 (+) non-ribosomal peptide synthetase
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              • CAM59607.1
              • aerH
              		 22651 - 23382 (+) putative dioxygenase
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                • CAM59608.1
                • aerI
                		 23429 - 24685 (-) putative glycosyltransferase
                • Tailoring
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                • CAM59609.1
                • ORF4
                		 24913 - 25602 (+) hypothetical protein
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                  • CAM59610.1
                  • ORF5
                  		 26387 - 26899 (+) hypothetical protein
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                    • CAM59611.1
                    • ORF6
                    		 26844 - 28130 (+) hypothetical protein
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                      • CAM59612.1
                      • ORF7
                      		 28548 - 29246 (+) hypothetical protein
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                        • CAM59613.1
                        • ORF8
                        		 29310 - 30470 (+) hypothetical protein
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                          • CAM59614.1
                          • ORF9
                          		 30626 - >31426 (+) hypothetical protein
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                            Biosynthesis information

                            Biosynthetic modules

                            Name
                            1
                            Type
                            nrps-type1
                            Genes
                            aerB
                            Substrates
                            leucine (evidence: Sequence-based prediction)
                            Integrated Monomers
                            Domains
                            condensation (LCL), adenylation, epimerase
                            Name
                            2
                            Type
                            nrps-type1
                            Genes
                            aerG
                            Substrates
                            2-carboxy-6-hydroxyoctahydroindole (evidence: )
                            Integrated Monomers
                            Domains
                            condensation (DCL), adenylation
                            Annotation changelog

                            Entry version: 4

                            Date
                            Changes
                            Submitters
                            Reviewers
                            2022-10-07
                            Update chemical activity to schema version 2.11
                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                            Entry version: 3

                            Date
                            Changes
                            Submitters
                            Reviewers
                            2022-09-15
                            Updated NRP substrate specificities
                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                            Entry version: 2

                            Date
                            Changes
                            Submitters
                            Reviewers
                            2019-10-16
                            Migrated from v1.4
                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                            2019-10-16
                            Updated compound(s) information (NPAtlas curation)
                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                            Entry version: 1

                            Date
                            Changes
                            Submitters
                            Reviewers
                            2015-06-12
                            Submitted
                            • (ID: F65XGYSSLMUEJC2Q4T3BLCPS)
                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                            Detailed domain annotation
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