BGC0000298: aeruginosin 98-A biosynthetic gene cluster from Microcystis aeruginosa NIES-98
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Location: 1 - 25,401 nt. (total: 25,401 nt).
This entry is originally from NCBI GenBank FJ609416.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
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General
Compounds
Genes
Biosynthesis
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0000298
Short description aeruginosin 98-A biosynthetic gene cluster from Microcystis aeruginosa NIES-98
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: complete
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRPS (Type I)
Loci
FJ609416.1
via
Compounds
  • aeruginosin 98-A
  • aeruginosin 98-B
  • aeruginosin 98-C
Species Microcystis aeruginosa NIES-98 [taxonomy]
References
Chemical products information
aeruginosin 98-A Evidence:
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C29H45Cl1N6O9S1
Chemical database entries
NPAtlas
ChemSpider
aeruginosin 98-B Evidence:
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C29H46N6O9S1
Chemical database entries
ChemSpider
PubCHEM
NPAtlas
aeruginosin 98-C Evidence:
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C29H45Br1N6O9S1
Chemical database entries
NPAtlas
ChemSpider
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • ACM68682.1
  • aerA
 106 - 4365 (+) NRPS/PKS hybrid; aeruginosin synthetase; first module with adenylation, ketoreductase, and thiolation domains
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    • ACM68683.1
    • aerJ
    		 4610 - 6487 (+) FADH2-dependent halogenas
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      • ACM68684.1
      • aerB
      		 6611 - 11395 (+) "NRPS module; aeruginosin synthetase; second module with adenylation, condensation, thiolation, and epimerization domains
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        • ACM68685.1
        • aerK
        		 11435 - 12478 (+) putative isopentenyl pyrophosphate isomerase
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          • ACM68686.1
          • aerD
          		 12472 - 13104 (+) AerD
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            • ACM68687.1
            • aerE
            		 13201 - 13827 (+) AerE
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              • ACM68688.1
              • aerF
              		 13876 - 14676 (+) short-chain dehydrogenase/reductase
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                • ACM68689.1
                • aerL
                		 14715 - 15659 (+) putative sulfotransferase
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                  • ACM68690.1
                  • aerG1
                  		 15751 - 19029 (+) NRPS module; aeruginosin synthetase; third module with adenylation, condensation, and thiolation domains
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                    • ACM68691.1
                    • aerG2
                    		 19068 - 20804 (+) NRPS module (truncated)
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                      • ACM68692.1
                      		 20865 - 21641 (+) putative oxidoreductase
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                        • aerM_
                        		 21722 - 22234 (+)
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                          • ACM68693.1
                          		 22314 - 22922 (+) hypothetical protein
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                            • ACM68694.1
                            • aerN
                            		 23096 - 25090 (+) ABC-type transporter
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                              Biosynthesis information

                              Biosynthetic modules

                              Name
                              1
                              Type
                              nrps-type1
                              Genes
                              aerB
                              Substrates
                              isoleucine (evidence: Sequence-based prediction)
                              Integrated Monomers
                              Domains
                              condensation, adenylation, epimerase
                              Name
                              2
                              Type
                              nrps-type1
                              Genes
                              aerG1
                              Substrates
                              2-carboxy-6-hydroxyoctahydroindole (evidence: )
                              Integrated Monomers
                              Domains
                              condensation (DCL), adenylation
                              Annotation changelog

                              Entry version: next

                              Date
                              Changes
                              Submitters
                              Reviewers
                              2024-05-14
                              MIBiG v4 annotathon
                              • (ID: NHJ6M55E7ZEHUFNMEG4QIZWY)
                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                              Entry version: 4

                              Date
                              Changes
                              Submitters
                              Reviewers
                              2022-10-07
                              Update chemical activity to schema version 2.11
                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                              Entry version: 3

                              Date
                              Changes
                              Submitters
                              Reviewers
                              2022-09-15
                              Corrected NRP module activity
                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                              2022-09-15
                              Updated bioactivity data
                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                              2022-09-15
                              Updated NRP substrate specificities
                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                              Entry version: 2

                              Date
                              Changes
                              Submitters
                              Reviewers
                              2019-10-16
                              Migrated from v1.4
                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                              2019-10-16
                              Updated compound(s) information (NPAtlas curation)
                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                              Entry version: 1

                              Date
                              Changes
                              Submitters
                              Reviewers
                              2015-06-12
                              Submitted
                              • (ID: F65XGYSSLMUEJC2Q4T3BLCPS)
                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                              Detailed domain annotation
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