Genomic loci for this biosynthetic pathway

Cluster Type From To
The following clusters are from record BGC0000298.1:
Cluster 1NRP125401

BGC0000298, aeruginosin biosynthetic gene cluster from Microcystis aeruginosa. Locus 1. Full MIBiG entry.

Chemical compounds

Compound: Aeruginosin 98-A
ChemSpider ID: 8502749
SMILES string: Copy to clipboard
Molecular formula:
Average molecular mass: Da
Molecular activity: Inhibitor
Molecular target: Trypsin, Plasmin, Thrombin

Class-specific details

Biosynthetic class(es):
NRP
Other (linear)
Thioesterase type:
None
Release / cyclization type:
None

Nonribosomal peptide synthetases:
aerA (ACM68682.1)
Module 0
A specificity: Unknown
Evidence for specificity: Unknown
C domain subtype: None
Scaffold-modifying domain: Keto reductase
aerB (ACM68684.1)
Module 1
A specificity: Isoleucine
Evidence for specificity: Sequence-based prediction
AA is epimerized
C domain subtype: Other
aerG1 (ACM68690.1)
Module 2
A specificity: 2-carboxy-6-hydroxyoctahydroindole
Evidence for specificity: Unknown
Amino acid biosynthesis subcluster: acm68685.1,acm68686.1,acm68687.1,acm68688.1
C domain subtype: DCL
aerG2 (ACM68691.1)
Module 3
A specificity: None
Evidence for specificity: Unknown
C domain subtype: LCL

Gene cluster description

aeruginosin (BGC0000298). Gene Cluster 1. Biosynthetic class = NRP. GenBank FJ609416. Click on genes for more information.

Legend:

biosynthetic genes
transport-related genes
regulatory genes
other genes

Domain annotation

Homologous known gene clusters

General MIBiG information on this cluster

Complete gene cluster sequence?complete
Evidence for cluster-compound connection:Sequence-based prediction
MIxS-compliance:Unknown
Contact for this cluster:Keishi Ishida (Leipniz Institute for Natural Product Research and Infection Biology)

Literature references

1. Mahlstedt S et al. (2010) Prephenate decarboxylases: a new prephenate-utilizing enzyme family that performs nonaromatizing decarboxylation en route to diverse secondary metabolites. Biochemistry 49(42):9021-3. doi: 10.1021/bi101457h.
2. Ishida K et al. (2007) Biosynthesis and structure of aeruginoside 126A and 126B, cyanobacterial peptide glycosides bearing a 2-carboxy-6-hydroxyoctahydroindole moiety. Chem Biol 14(5):565-576. doi: 10.1016/j.chembiol.2007.04.006.
3. Cadel-Six S et al. (2008) Halogenase genes in nonribosomal peptide synthetase gene clusters of Microcystis (cyanobacteria): sporadic distribution and evolution. Mol Biol Evol 25(9):2031-41. doi: 10.1093/molbev/msn150. Epub 2008 Jul