BGC0000300: amychelin biosynthetic gene cluster from Streptomyces sp. AA4
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
View antiSMASH-generated output
Download Cluster GenBank file
Download region SVG
Location: 2,722,391 - 2,757,628 nt. (total: 35,238 nt).
This entry is originally from NCBI GenBank GG657746.1.

Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
reset zoomreset view
zoomzoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
General
Compounds
Genes
NRP
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0000300
Short description amychelin biosynthetic gene cluster from Streptomyces sp. AA4
Status Minimal annotation: no
A minimal annotation only contains information on the BGC loci and one or more linked chemical product(s)

Completeness: Unknown
Whether the loci encodes everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRP
Loci NCBI GenBank: GG657746.1
Compounds
  • amychelin
Species Streptomyces sp. AA4 [taxonomy]
References
Chemical products information
amychelin
Copy SMILES
C30H42N8O14
Chemical database entries
NPAtlas
PubCHEM
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • SSMG_02531
  • EFL06860.1
 2722391 - 2722987 (-) TetR family transcriptional regulator
copy AA seq
copy Nt seq
  • SSMG_02532
  • EFL06861.1
 2723073 - 2724563 (+) predicted protein
copy AA seq
copy Nt seq
  • SSMG_02533
  • EFL06862.1
 2724610 - 2725971 (+) amine oxidase
copy AA seq
copy Nt seq
  • SSMG_02534
  • EFL06863.1
 2726287 - 2727519 (+) predicted protein
copy AA seq
copy Nt seq
  • SSMG_02535
  • EFL06864.1
 2727576 - 2730929 (-) non-ribosomal peptide synthetase
copy AA seq
copy Nt seq
  • SSMG_02536
  • EFL06865.1
 2730923 - 2738011 (-) hypothetical protein
copy AA seq
copy Nt seq
  • SSMG_02537
  • EFL06866.1
 2738004 - 2742209 (-) predicted protein
copy AA seq
copy Nt seq
  • SSMG_02538
  • EFL06867.1
 2742194 - 2749195 (-) predicted protein
copy AA seq
copy Nt seq
  • SSMG_02539
  • EFL06868.1
 2749192 - 2749413 (-) mbtH protein
copy AA seq
copy Nt seq
  • SSMG_02540
  • EFL06869.1
 2749462 - 2750268 (-) LipE protein
copy AA seq
copy Nt seq
  • SSMG_02541
  • EFL06870.1
 2750241 - 2751416 (-) major facilitator superfamily transporter multidrug resistance protein
copy AA seq
copy Nt seq
  • SSMG_02542
  • EFL06871.1
 2751559 - 2753106 (+) 2,3-dihydroxybenzoate-AMP ligase
copy AA seq
copy Nt seq
  • SSMG_02543
  • EFL06872.1
 2753103 - 2754086 (+) predicted protein
copy AA seq
copy Nt seq
  • SSMG_02544
  • EFL06873.1
 2754083 - 2755066 (+) predicted protein
copy AA seq
copy Nt seq
  • SSMG_02545
  • EFL06874.1
 2755074 - 2756384 (-) salicylate synthase
copy AA seq
copy Nt seq
  • SSMG_02546
  • EFL06875.1
 2756348 - 2757628 (-) peptide monooxygenase
copy AA seq
copy Nt seq
NRP-specific information
Subclass N/A
Cyclic? no
NRP-synthases
Gene Modules
SSMG_02535
Module ?
Specificity: serine
Evidence for specificity:
  • Structure-based inference
  • X-ray crystallography
SSMG_02536
Module ?
Specificity: serine
Evidence for specificity:
  • Structure-based inference
  • X-ray crystallography
Module ?
Specificity: serine
Evidence for specificity:
  • Structure-based inference
  • X-ray crystallography
SSMG_02537
Module ?
Specificity: N5-hydroxyornithine
Evidence for specificity:
  • Structure-based inference
  • X-ray crystallography
SSMG_02538
Module ?
Specificity: serine
Evidence for specificity:
  • Structure-based inference
  • X-ray crystallography
Module ?
Specificity: N5-formyl-N5-hydroxyornithine
Evidence for specificity:
  • Structure-based inference
  • X-ray crystallography
SSMG_02542
Module ?
Specificity: salicylic acid
Evidence for specificity:
  • Homology
  • X-ray crystallography
Annotation changelog
MIBiG version Submitter Notes
1.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Submitted
2.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Migrated from v1.4
  • Updated compound(s) information (NPAtlas curation)
3.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Updated bioactivity data
  • Added NRP substrate specificities
3.1
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Update chemical activity to schema version 2.11
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A glossary is available here.
Selected features only
Show module domains
Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.