BGC0000300: amychelin biosynthetic gene cluster from Streptomyces sp. AA4
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Location: 2,722,391 - 2,757,628 nt. (total: 35,238 nt).
This entry is originally from NCBI GenBank GG657746.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
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General
Compounds
Genes
Biosynthesis
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0000300
Short description amychelin biosynthetic gene cluster from Streptomyces sp. AA4
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: unknown
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRPS (Type I)
Loci
GG657746.1
2722391 - 2757628
via
Compounds
  • amychelin
Species Streptomyces sp. AA4 [taxonomy]
References
Chemical products information
amychelin Evidence:
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C30H42N8O14
Chemical database entries
NPAtlas
PubCHEM
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • SSMG_02531
  • EFL06860.1
 2722391 - 2722987 (-) TetR family transcriptional regulator
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    • SSMG_02532
    • EFL06861.1
    		 2723073 - 2724563 (+) predicted protein
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      • SSMG_02533
      • EFL06862.1
      		 2724610 - 2725971 (+) amine oxidase
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        • SSMG_02534
        • EFL06863.1
        		 2726287 - 2727519 (+) predicted protein
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          • SSMG_02535
          • EFL06864.1
          		 2727576 - 2730929 (-) non-ribosomal peptide synthetase
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            • SSMG_02536
            • EFL06865.1
            		 2730923 - 2738011 (-) hypothetical protein
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              • SSMG_02537
              • EFL06866.1
              		 2738004 - 2742209 (-) predicted protein
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                • SSMG_02538
                • EFL06867.1
                		 2742194 - 2749195 (-) predicted protein
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                  • SSMG_02539
                  • EFL06868.1
                  		 2749192 - 2749413 (-) mbtH protein
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                    • SSMG_02540
                    • EFL06869.1
                    		 2749462 - 2750268 (-) LipE protein
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                      • SSMG_02541
                      • EFL06870.1
                      		 2750241 - 2751416 (-) major facilitator superfamily transporter multidrug resistance protein
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                        • SSMG_02542
                        • EFL06871.1
                        		 2751559 - 2753106 (+) 2,3-dihydroxybenzoate-AMP ligase
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                          • SSMG_02543
                          • EFL06872.1
                          		 2753103 - 2754086 (+) predicted protein
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                            • SSMG_02544
                            • EFL06873.1
                            		 2754083 - 2755066 (+) predicted protein
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                              • SSMG_02545
                              • EFL06874.1
                              		 2755074 - 2756384 (-) salicylate synthase
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                                • SSMG_02546
                                • EFL06875.1
                                		 2756348 - 2757628 (-) peptide monooxygenase
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                                  Biosynthesis information

                                  Biosynthetic modules

                                  Name
                                  Unk01
                                  Type
                                  nrps-type1
                                  Genes
                                  SSMG_02535
                                  Substrates
                                  serine (evidence: Structure-based inference, X-ray crystallography)
                                  Integrated Monomers
                                  Domains
                                  adenylation
                                  Name
                                  Unk02
                                  Type
                                  nrps-type1
                                  Genes
                                  SSMG_02536
                                  Substrates
                                  serine (evidence: Structure-based inference, X-ray crystallography)
                                  Integrated Monomers
                                  Domains
                                  adenylation
                                  Name
                                  Unk03
                                  Type
                                  nrps-type1
                                  Genes
                                  SSMG_02536
                                  Substrates
                                  serine (evidence: Structure-based inference, X-ray crystallography)
                                  Integrated Monomers
                                  Domains
                                  adenylation
                                  Name
                                  Unk04
                                  Type
                                  nrps-type1
                                  Genes
                                  SSMG_02537
                                  Substrates
                                  N5-hydroxyornithine (evidence: Structure-based inference, X-ray crystallography)
                                  Integrated Monomers
                                  Domains
                                  adenylation
                                  Name
                                  Unk05
                                  Type
                                  nrps-type1
                                  Genes
                                  SSMG_02538
                                  Substrates
                                  serine (evidence: Structure-based inference, X-ray crystallography)
                                  Integrated Monomers
                                  Domains
                                  adenylation
                                  Name
                                  Unk06
                                  Type
                                  nrps-type1
                                  Genes
                                  SSMG_02538
                                  Substrates
                                  N5-formyl-N5-hydroxyornithine (evidence: Structure-based inference, X-ray crystallography)
                                  Integrated Monomers
                                  Domains
                                  adenylation
                                  Name
                                  Unk07
                                  Type
                                  nrps-type1
                                  Genes
                                  SSMG_02542
                                  Substrates
                                  salicylic acid (evidence: Homology, X-ray crystallography)
                                  Integrated Monomers
                                  Domains
                                  adenylation
                                  Annotation changelog

                                  Entry version: 4

                                  Date
                                  Changes
                                  Submitters
                                  Reviewers
                                  2022-10-07
                                  Update chemical activity to schema version 2.11
                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                  Entry version: 3

                                  Date
                                  Changes
                                  Submitters
                                  Reviewers
                                  2022-09-15
                                  Updated bioactivity data
                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                  2022-09-15
                                  Added NRP substrate specificities
                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                  Entry version: 2

                                  Date
                                  Changes
                                  Submitters
                                  Reviewers
                                  2019-10-16
                                  Migrated from v1.4
                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                  2019-10-16
                                  Updated compound(s) information (NPAtlas curation)
                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                  Entry version: 1

                                  Date
                                  Changes
                                  Submitters
                                  Reviewers
                                  2015-06-12
                                  Submitted
                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
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