LOCUS       BGC0000301             23949 bp    DNA     linear   BCT 21-JUL-2011
DEFINITION  Planktothrix agardhii NIVA-CYA 126/8 anabaenopeptin biosynthesis
            gene cluster, complete sequence.
ACCESSION   BGC0000301
VERSION     BGC0000301
KEYWORDS    .
SOURCE      Planktothrix agardhii NIVA-CYA 126/8
  ORGANISM  Planktothrix agardhii NIVA-CYA 126/8
            Bacteria; Cyanobacteriota; Cyanophyceae; Oscillatoriophycideae;
            Oscillatoriales; Microcoleaceae; Planktothrix.
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-10-17 13:21:05
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     gene            1..6501
                     /gene="apnA"
     CDS             1..6501
                     /NRPS_PKS="Domain: AMP-binding (9-417). E-value: 3.1e-113.
                     Score: 370.3. Matches aSDomain:
                     nrpspksdomains_apnA_AMP-binding.1"
                     /NRPS_PKS="Domain: PCP (527-596). E-value: 1.6e-25. Score:
                     80.9. Matches aSDomain: nrpspksdomains_apnA_PCP.1"
                     /NRPS_PKS="Domain: Condensation_LCL (616-916). E-value:
                     1.9e-98. Score: 321.0. Matches aSDomain:
                     nrpspksdomains_apnA_Condensation_LCL.1"
                     /NRPS_PKS="Domain: AMP-binding (1098-1502). E-value:
                     3.4e-113. Score: 370.2. Matches aSDomain:
                     nrpspksdomains_apnA_AMP-binding.2"
                     /NRPS_PKS="Domain: PCP (1610-1676). E-value: 9.6e-26.
                     Score: 81.7. Matches aSDomain: nrpspksdomains_apnA_PCP.2"
                     /NRPS_PKS="Domain: Epimerization (1688-1993). E-value:
                     9.2e-142. Score: 465.2. Matches aSDomain:
                     nrpspksdomains_apnA_Epimerization.1"
                     /NRPS_PKS="Domain: TIGR01720 (1999-2153). E-value: 2.7e-43.
                     Score: 139.3. Matches aSDomain:
                     nrpspksdomains_apnA_TIGR01720.1"
                     /NRPS_PKS="Domain: NRPS-COM_Cterm (2137-2158). E-value:
                     1.1e-08. Score: 26.6. Matches aSDomain:
                     nrpspksdomains_apnA_NRPS-COM_Cterm.1"
                     /codon_start=1
                     /gene="apnA"
                     /gene_functions="biosynthetic (rule-based-clusters) NRPS:
                     Condensation"
                     /gene_functions="biosynthetic (rule-based-clusters) NRPS:
                     AMP-binding"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1002:AMP-dependent synthetase and ligase (Score:
                     368.7; E-value: 6.2e-112)"
                     /gene_kind="biosynthetic"
                     /note="nonribosomal peptide synthetase; A1-T-C-A2-T-E;
                     A1:activation of both arginine and tyrosine, A2: activation
                     of lysine"
                     /product="ApnA"
                     /protein_id="ABV79985.1"
                     /sec_met_domain="AMP-binding (E-value: 7.8e-122, bitscore:
                     395.1, seeds: 400, tool: rule-based-clusters)"
                     /sec_met_domain="PP-binding (E-value: 6.3e-17, bitscore:
                     50.4, seeds: 164, tool: rule-based-clusters)"
                     /sec_met_domain="Condensation (E-value: 3.7e-68, bitscore:
                     218.1, seeds: 42, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MFKQSIHQLFETQVERAPEAVAVLSEQGQLTYEELNTKANQLAHY
                     LRTLGVKSETLVGLCVDRSLEMIIGLLAILKAGGAYVPLDPTYPRERLTYMVQDAQISV
                     LVTQTQWSNLISDYEGQVVCLDSQWAKIASCSQENLVNTVNPENLAYVIYTSGSTGKPK
                     GVMIEHQSLVNFTKLAIAQYQITKRDRTLQFVSISFDVAAEEIYVTLCSGATLILRTEE
                     MISSIPSFVQKSQDWQITVWSLPTAYWHLLVNELVKSKIALPDSLRLVIIGGERVQPEL
                     VRMWFKNVGNFPELINAYGPTEGTIAVSLCRLSQLAESQRNRTEIPIGKSLGENISVYV
                     LDETLKTVSPETPGEIYIGGTAVARGYLNRPELTAQKFIQAPFSPSERLYKTGDLGRYL
                     ADGNLEYLGRVDHQVKINGFRVELGEIETVLLQHHQVAQAVVIDREDTLGNKRLVAYLI
                     PHSKEENLTETLQQFLKDQLPSYMIPATFVVLNELPLSPNGKIDRKALPVPDYDGNERQ
                     TPFIAPRNQQEEKLAKIWHQVFGLEKIGVNDNFFHLGGHSLIATQILSRIRDIFEIEVS
                     FKKLLENPTIGDLSQTITEQQQDKKTTSFKTIKPIARDGYLPVSFAQERVYFIEQLAPS
                     ITAYQFQESLRIKGFLDVSILEKSISEILRRHEIFRTTFPSVAGKLVQVIHPPEPVTIP
                     IIDLQNISKDKQQEEVQKLTEQAIHKPFDISQLPLIHWTLLKLNEQEWVLIHVEHHMVH
                     DGWSFNLFLKELVTLYQAFSQGKPSPLSEPSLQFVDFAHWQREWTKTEEATTQLNYWHQ
                     KLAGIPPLLELPYDRPRPTEQTYGGGRVRVDLPLDICQLLRSLGRQEGVTLFMSMFAVF
                     VAQIYRYTGQEDICVGSGVANRRLRETEGLIGMIVNNIVLRTDVSGNPTFKQLLEQVRQ
                     VTLEGYANEDLPFDKVVEVLKPVRHLSYNPLFQVMFSFHDAQLPDLNLPGLSIKPNDAL
                     ANNSAKFDLDIVVIPRSEQRVGRNSTAETKGIETEGITMVWEYNTGLFEESTINRMVED
                     YQTLLQEILTNPNQRLSQYSLLTEQQKHQLLVEWNNTQAEYPKVKGIHQLFEEQVKKTP
                     EAIAVIFEDKYLSYQQLNEQANQLAHYLQTLGVEADNLVGIFLDRSLEMLIGLLGILKA
                     GGAYLPLDPSYPEDRLAYMVNDAQVSIVVTLEKWANLTTQQALQWVCLDSQKDIIAQQS
                     SNNINVAIEEKNLAYVIYTSGSTGQPKGVLIEHQSLINFTKSAIEKYEITEQDTVLQFA
                     SINFDAAAEEIYPCLSSGGTLVLRTEEMMKSVSAFIQESQKKEVTIWDLPTAYWHLLVS
                     EIIQENLQLPPSLRLVILGGERVLPERVKMWQEYVGQYPQLVNSYGPTESTVVSTLHYL
                     EESPINQAEIPIGKPINNVQVYILDQYLQPMPIGVPGELHIGGLGIARGYLNRPELTVE
                     KFIDNPFKAGEKLYKTGDLVRYKFNGNLEFLGRIDSQVKIRGFRIELTEIETVLNQYSS
                     IKQSVVIAREDSPGIKRLVAYIVGNKNQNKIEEIRYYLKQKLPPYMVPSAFVFLEEIPI
                     TTNGKVDHRALPIPEMTSSLASEFTAPKTPIEERLTAIWAEVLRLEKVSIHDNFFELGG
                     DSIISIQMISKANQMGLQLSPKQLFQYQTIAELATVVGIDKQIKANQGLVTGIIPLTPI
                     QHWLFEQDLPDVNYFNQSALIEVTATVNPERLKQVIQALLNHHDALRLHYLQEGESLTQ
                     ISETTKDAIPLEVIDLSQLSPSAQKTAIIAKDEETQRSLNLTTGDIVKVVLFNLGNEQP
                     SQLLIVIHHLAIDGISWRILLEDLATAYQQISQSQEIKLPLKTTSFQDWSNQLVTYSQS
                     EKLKQERDYWISQLTKEIASLPMDYSGTKESNQLSSAKAINLFLNEEETRGLLQDVPGV
                     YNTQINDVLLTALLESFSQWTGEKSLIVDLEGHGREDLFEVIDLSRTVGWFTTLFPVRL
                     EGSKTGQLPETLKSVKEQLRRLPNRGIGHGILKYLSKDQEVKKQFQDLIKAQVSFNYLG
                     QFDQVLSASGVLGEVKEWKTERSLVGNRSHLLEISGLIRSQKLEMQFVYSEKVHQRETI
                     ERLANGFMSVLKSLIIHCQSSKDKGYTPSDFSAAQVSQEQLDKFLSKINQKKGKTR"
     source          1..23949
                     /db_xref="taxon:388467"
                     /mol_type="genomic DNA"
                     /organism="Planktothrix agardhii NIVA-CYA 126/8"
                     /strain="NIVA-CYA 126/8"
     misc_feature    1..23949
                     /note="anabaenopeptin biosynthesis gene cluster"
     protocluster    1..23949
                     /aStool="rule-based-clusters"
                     /category="NRPS"
                     /contig_edge="True"
                     /core_location="[0:21865]"
                     /cutoff="20000"
                     /detection_rule="cds(Condensation and (AMP-binding or
                     A-OX))"
                     /neighbourhood="20000"
                     /product="NRPS"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      1..21865
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="cds(Condensation and (AMP-binding or
                     A-OX))"
                     /neighbourhood="20000"
                     /product="NRPS"
                     /protocluster_number="1"
     cand_cluster    1..23949
                     /SMILES="NC(CCCNC(N)=N)C(=O)NC(CCCCN)C(=O)NC(C(C)C)C(=O)NC(
                     [*])C(=O)NC([*])C(=O)NC(C(C)CC)C(=O)O"
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="cds(Condensation and (AMP-binding or
                     A-OX))"
                     /kind="single"
                     /product="NRPS"
                     /protoclusters="1"
                     /tool="antismash"
     subregion       1..23949
                     /aStool="externally annotated by: MIBiG"
                     /contig_edge="True"
                     /label="BGC0000301"
                     /subregion_number="1"
                     /tool="antismash"
     region          1..23949
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="NRPS"
                     /region_number="1"
                     /rules="cds(Condensation and (AMP-binding or A-OX))"
                     /subregion_numbers="1"
                     /tool="antismash"
     aSDomain        28..1251
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_apnA_AMP-binding.1"
                     /evalue="3.10E-113"
                     /label="apnA_AMP-binding.1"
                     /locus_tag="apnA"
                     /protein_end="417"
                     /protein_start="9"
                     /score="370.3"
                     /specificity="substrate consensus: Arg"
                     /tool="antismash"
                     /translation="FETQVERAPEAVAVLSEQGQLTYEELNTKANQLAHYLRTLGVKSE
                     TLVGLCVDRSLEMIIGLLAILKAGGAYVPLDPTYPRERLTYMVQDAQISVLVTQTQWSN
                     LISDYEGQVVCLDSQWAKIASCSQENLVNTVNPENLAYVIYTSGSTGKPKGVMIEHQSL
                     VNFTKLAIAQYQITKRDRTLQFVSISFDVAAEEIYVTLCSGATLILRTEEMISSIPSFV
                     QKSQDWQITVWSLPTAYWHLLVNELVKSKIALPDSLRLVIIGGERVQPELVRMWFKNVG
                     NFPELINAYGPTEGTIAVSLCRLSQLAESQRNRTEIPIGKSLGENISVYVLDETLKTVS
                     PETPGEIYIGGTAVARGYLNRPELTAQKFIQAPFSPSERLYKTGDLGRYLADGNLEYLG
                     RVDHQVKIN"
     aSModule        28..1788
                     /complete
                     /domains="nrpspksdomains_apnA_AMP-binding.1"
                     /domains="nrpspksdomains_apnA_PCP.1"
                     /locus_tags="apnA"
                     /monomer_pairings="Arg -> Arg"
                     /starter_module
                     /tool="antismash"
                     /type="nrps"
     CDS_motif       214..255
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_apnA_0001"
                     /evalue="4.20E-06"
                     /label="NRPS-A_a2"
                     /locus_tag="apnA"
                     /protein_end="85"
                     /protein_start="71"
                     /score="19.8"
                     /tool="antismash"
                     /translation="LAILKAGGAYVPLD"
     CDS_motif       448..507
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_apnA_0002"
                     /evalue="1.50E-11"
                     /label="NRPS-A_a3"
                     /locus_tag="apnA"
                     /protein_end="169"
                     /protein_start="149"
                     /score="35.9"
                     /tool="antismash"
                     /translation="AYVIYTSGSTGKPKGVMIEH"
     CDS_motif       895..921
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_apnA_0003"
                     /evalue="2.70E-01"
                     /label="NRPS-A_a5"
                     /locus_tag="apnA"
                     /protein_end="307"
                     /protein_start="298"
                     /score="4.7"
                     /tool="antismash"
                     /translation="YGPTEGTIA"
     CDS_motif       1054..1134
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_apnA_0004"
                     /evalue="7.70E-15"
                     /label="NRPS-A_a6"
                     /locus_tag="apnA"
                     /protein_end="378"
                     /protein_start="351"
                     /score="47.0"
                     /tool="antismash"
                     /translation="TPGEIYIGGTAVARGYLNRPELTAQKF"
     CDS_motif       1216..1281
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_apnA_0005"
                     /evalue="6.90E-12"
                     /label="NRPS-A_a8"
                     /locus_tag="apnA"
                     /protein_end="427"
                     /protein_start="405"
                     /score="37.3"
                     /tool="antismash"
                     /translation="YLGRVDHQVKINGFRVELGEIE"
     CDS_motif       1495..1521
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_apnA_0006"
                     /evalue="1.20E-01"
                     /label="NRPS-A_a10"
                     /locus_tag="apnA"
                     /protein_end="507"
                     /protein_start="498"
                     /score="5.4"
                     /tool="antismash"
                     /translation="GKIDRKALP"
     aSDomain        1582..1788
                     /aSDomain="PCP"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_apnA_PCP.1"
                     /evalue="1.60E-25"
                     /label="apnA_PCP.1"
                     /locus_tag="apnA"
                     /protein_end="596"
                     /protein_start="527"
                     /score="80.9"
                     /tool="antismash"
                     /translation="EEKLAKIWHQVFGLEKIGVNDNFFHLGGHSLIATQILSRIRDIFE
                     IEVSFKKLLENPTIGDLSQTITEQ"
     aSDomain        1849..2748
                     /aSDomain="Condensation"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_apnA_Condensation_LCL.1"
                     /domain_subtypes="Condensation_LCL"
                     /evalue="1.90E-98"
                     /label="apnA_Condensation_LCL.1"
                     /locus_tag="apnA"
                     /protein_end="916"
                     /protein_start="616"
                     /score="321.0"
                     /tool="antismash"
                     /translation="LPVSFAQERVYFIEQLAPSITAYQFQESLRIKGFLDVSILEKSIS
                     EILRRHEIFRTTFPSVAGKLVQVIHPPEPVTIPIIDLQNISKDKQQEEVQKLTEQAIHK
                     PFDISQLPLIHWTLLKLNEQEWVLIHVEHHMVHDGWSFNLFLKELVTLYQAFSQGKPSP
                     LSEPSLQFVDFAHWQREWTKTEEATTQLNYWHQKLAGIPPLLELPYDRPRPTEQTYGGG
                     RVRVDLPLDICQLLRSLGRQEGVTLFMSMFAVFVAQIYRYTGQEDICVGSGVANRRLRE
                     TEGLIGMIVNNIVLRTDVS"
     aSModule        1849..6459
                     /complete
                     /domains="nrpspksdomains_apnA_Condensation_LCL.1"
                     /domains="nrpspksdomains_apnA_AMP-binding.2"
                     /domains="nrpspksdomains_apnA_PCP.2"
                     /domains="nrpspksdomains_apnA_Epimerization.1"
                     /domains="nrpspksdomains_apnA_TIGR01720.1"
                     /locus_tags="apnA"
                     /monomer_pairings="Lys -> D-Lys"
                     /tool="antismash"
                     /type="nrps"
     CDS_motif       1909..2025
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_apnA_0007"
                     /evalue="3.20E-13"
                     /label="C2_LCL_024-062"
                     /locus_tag="apnA"
                     /protein_end="675"
                     /protein_start="636"
                     /score="42.0"
                     /tool="antismash"
                     /translation="TAYQFQESLRIKGFLDVSILEKSISEILRRHEIFRTTFP"
     CDS_motif       2245..2307
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_apnA_0008"
                     /evalue="1.30E-08"
                     /label="C3_LCL_132-143"
                     /locus_tag="apnA"
                     /protein_end="769"
                     /protein_start="748"
                     /score="27.3"
                     /tool="antismash"
                     /translation="HHMVHDGWSFNLFLKELVTLY"
     CDS_motif       2356..2391
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_apnA_0009"
                     /evalue="2.20E-04"
                     /label="C4_LCL_164-176"
                     /locus_tag="apnA"
                     /protein_end="797"
                     /protein_start="785"
                     /score="13.9"
                     /tool="antismash"
                     /translation="QFVDFAHWQREW"
     CDS_motif       2647..2736
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_apnA_0010"
                     /evalue="2.80E-10"
                     /label="C5_LCL_267-296"
                     /locus_tag="apnA"
                     /protein_end="912"
                     /protein_start="882"
                     /score="32.6"
                     /tool="antismash"
                     /translation="DICVGSGVANRRLRETEGLIGMIVNNIVLR"
     CDS_motif       2785..2904
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_apnA_0011"
                     /evalue="1.10E-20"
                     /label="C67_LCL_14fromHMM"
                     /locus_tag="apnA"
                     /protein_end="968"
                     /protein_start="928"
                     /score="66.0"
                     /tool="antismash"
                     /translation="RQVTLEGYANEDLPFDKVVEVLKPVRHLSYNPLFQVMFSF"
     aSDomain        3295..4506
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_apnA_AMP-binding.2"
                     /evalue="3.40E-113"
                     /label="apnA_AMP-binding.2"
                     /locus_tag="apnA"
                     /protein_end="1502"
                     /protein_start="1098"
                     /score="370.2"
                     /specificity="substrate consensus: Lys"
                     /tool="antismash"
                     /translation="FEEQVKKTPEAIAVIFEDKYLSYQQLNEQANQLAHYLQTLGVEAD
                     NLVGIFLDRSLEMLIGLLGILKAGGAYLPLDPSYPEDRLAYMVNDAQVSIVVTLEKWAN
                     LTTQQALQWVCLDSQKDIIAQQSSNNINVAIEEKNLAYVIYTSGSTGQPKGVLIEHQSL
                     INFTKSAIEKYEITEQDTVLQFASINFDAAAEEIYPCLSSGGTLVLRTEEMMKSVSAFI
                     QESQKKEVTIWDLPTAYWHLLVSEIIQENLQLPPSLRLVILGGERVLPERVKMWQEYVG
                     QYPQLVNSYGPTESTVVSTLHYLEESPINQAEIPIGKPINNVQVYILDQYLQPMPIGVP
                     GELHIGGLGIARGYLNRPELTVEKFIDNPFKAGEKLYKTGDLVRYKFNGNLEFLGRIDS
                     QVKIR"
     CDS_motif       3481..3522
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_apnA_0012"
                     /evalue="2.30E-05"
                     /label="NRPS-A_a2"
                     /locus_tag="apnA"
                     /protein_end="1174"
                     /protein_start="1160"
                     /score="17.5"
                     /tool="antismash"
                     /translation="LGILKAGGAYLPLD"
     CDS_motif       3715..3774
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_apnA_0013"
                     /evalue="1.10E-10"
                     /label="NRPS-A_a3"
                     /locus_tag="apnA"
                     /protein_end="1258"
                     /protein_start="1238"
                     /score="33.2"
                     /tool="antismash"
                     /translation="AYVIYTSGSTGQPKGVLIEH"
     CDS_motif       4159..4188
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_apnA_0014"
                     /evalue="4.30E-02"
                     /label="NRPS-A_a5"
                     /locus_tag="apnA"
                     /protein_end="1396"
                     /protein_start="1386"
                     /score="7.0"
                     /tool="antismash"
                     /translation="SYGPTESTVV"
     CDS_motif       4300..4389
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_apnA_0015"
                     /evalue="1.30E-16"
                     /label="NRPS-A_a6"
                     /locus_tag="apnA"
                     /protein_end="1463"
                     /protein_start="1433"
                     /score="52.6"
                     /tool="antismash"
                     /translation="PIGVPGELHIGGLGIARGYLNRPELTVEKF"
     CDS_motif       4471..4536
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_apnA_0016"
                     /evalue="1.90E-11"
                     /label="NRPS-A_a8"
                     /locus_tag="apnA"
                     /protein_end="1512"
                     /protein_start="1490"
                     /score="35.9"
                     /tool="antismash"
                     /translation="FLGRIDSQVKIRGFRIELTEIE"
     CDS_motif       4747..4773
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_apnA_0017"
                     /evalue="1.10E+00"
                     /label="NRPS-A_a10"
                     /locus_tag="apnA"
                     /protein_end="1591"
                     /protein_start="1582"
                     /score="2.9"
                     /tool="antismash"
                     /translation="GKVDHRALP"
     aSDomain        4831..5028
                     /aSDomain="PCP"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_apnA_PCP.2"
                     /evalue="9.60E-26"
                     /label="apnA_PCP.2"
                     /locus_tag="apnA"
                     /protein_end="1676"
                     /protein_start="1610"
                     /score="81.7"
                     /tool="antismash"
                     /translation="EERLTAIWAEVLRLEKVSIHDNFFELGGDSIISIQMISKANQMGL
                     QLSPKQLFQYQTIAELATVVG"
     aSDomain        5065..5979
                     /aSDomain="Epimerization"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_apnA_Epimerization.1"
                     /evalue="9.20E-142"
                     /label="apnA_Epimerization.1"
                     /locus_tag="apnA"
                     /protein_end="1993"
                     /protein_start="1688"
                     /score="465.2"
                     /tool="antismash"
                     /translation="TGIIPLTPIQHWLFEQDLPDVNYFNQSALIEVTATVNPERLKQVI
                     QALLNHHDALRLHYLQEGESLTQISETTKDAIPLEVIDLSQLSPSAQKTAIIAKDEETQ
                     RSLNLTTGDIVKVVLFNLGNEQPSQLLIVIHHLAIDGISWRILLEDLATAYQQISQSQE
                     IKLPLKTTSFQDWSNQLVTYSQSEKLKQERDYWISQLTKEIASLPMDYSGTKESNQLSS
                     AKAINLFLNEEETRGLLQDVPGVYNTQINDVLLTALLESFSQWTGEKSLIVDLEGHGRE
                     DLFEVIDLSRTVGWFTTLFPVRLE"
     CDS_motif       5080..5109
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_apnA_0018"
                     /evalue="8.20E-04"
                     /label="NRPS-E1"
                     /locus_tag="apnA"
                     /protein_end="1703"
                     /protein_start="1693"
                     /score="12.4"
                     /tool="antismash"
                     /translation="LTPIQHWLFE"
     CDS_motif       5137..5241
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_apnA_0019"
                     /evalue="1.90E-05"
                     /label="C2_LCL_024-062"
                     /locus_tag="apnA"
                     /protein_end="1747"
                     /protein_start="1712"
                     /score="17.1"
                     /tool="antismash"
                     /translation="NQSALIEVTATVNPERLKQVIQALLNHHDALRLHY"
     CDS_motif       5452..5517
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_apnA_0020"
                     /evalue="1.10E-10"
                     /label="NRPS-E2"
                     /locus_tag="apnA"
                     /protein_end="1839"
                     /protein_start="1817"
                     /score="33.8"
                     /tool="antismash"
                     /translation="LLIVIHHLAIDGISWRILLEDL"
     CDS_motif       5926..5976
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_apnA_0021"
                     /evalue="4.80E-09"
                     /label="NRPS-E5"
                     /locus_tag="apnA"
                     /protein_end="1992"
                     /protein_start="1975"
                     /score="28.1"
                     /tool="antismash"
                     /translation="DLSRTVGWFTTLFPVRL"
     aSDomain        5998..6459
                     /aSDomain="TIGR01720"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_apnA_TIGR01720.1"
                     /evalue="2.70E-43"
                     /label="apnA_TIGR01720.1"
                     /locus_tag="apnA"
                     /protein_end="2153"
                     /protein_start="1999"
                     /score="139.3"
                     /tool="antismash"
                     /translation="LPETLKSVKEQLRRLPNRGIGHGILKYLSKDQEVKKQFQDLIKAQ
                     VSFNYLGQFDQVLSASGVLGEVKEWKTERSLVGNRSHLLEISGLIRSQKLEMQFVYSEK
                     VHQRETIERLANGFMSVLKSLIIHCQSSKDKGYTPSDFSAAQVSQEQLDK"
     CDS_motif       6019..6081
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_apnA_0022"
                     /evalue="1.10E-09"
                     /label="NRPS-E6"
                     /locus_tag="apnA"
                     /protein_end="2027"
                     /protein_start="2006"
                     /score="30.5"
                     /tool="antismash"
                     /translation="VKEQLRRLPNRGIGHGILKYL"
     aSDomain        6412..6474
                     /aSDomain="NRPS-COM_Cterm"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_apnA_NRPS-COM_Cterm.1"
                     /evalue="1.10E-08"
                     /label="apnA_NRPS-COM_Cterm.1"
                     /locus_tag="apnA"
                     /protein_end="2158"
                     /protein_start="2137"
                     /score="26.6"
                     /tool="antismash"
                     /translation="PSDFSAAQVSQEQLDKFLSKI"
     gene            6507..9743
                     /gene="apnB"
     CDS             6507..9743
                     /NRPS_PKS="Domain: NRPS-COM_Nterm (1-27). E-value: 3.2e-18.
                     Score: 56.6. Matches aSDomain:
                     nrpspksdomains_apnB_NRPS-COM_Nterm.1"
                     /NRPS_PKS="Domain: Condensation_DCL (4-305). E-value:
                     7.5e-118. Score: 384.8. Matches aSDomain:
                     nrpspksdomains_apnB_Condensation_DCL.1"
                     /NRPS_PKS="Domain: AMP-binding (470-869). E-value: 2e-109.
                     Score: 357.7. Matches aSDomain:
                     nrpspksdomains_apnB_AMP-binding.1"
                     /NRPS_PKS="Domain: PCP (978-1044). E-value: 5.4e-27. Score:
                     85.7. Matches aSDomain: nrpspksdomains_apnB_PCP.1"
                     /codon_start=1
                     /gene="apnB"
                     /gene_functions="biosynthetic (rule-based-clusters) NRPS:
                     Condensation"
                     /gene_functions="biosynthetic (rule-based-clusters) NRPS:
                     AMP-binding"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1127:condensation domain-containing protein (Score:
                     346; E-value: 6.3e-105)"
                     /gene_kind="biosynthetic"
                     /note="nonribosomal peptide synthetase; C-A-T; activation
                     of valine"
                     /product="ApnB"
                     /protein_id="ABV79986.1"
                     /sec_met_domain="Condensation (E-value: 5.2e-81, bitscore:
                     260.3, seeds: 42, tool: rule-based-clusters)"
                     /sec_met_domain="AMP-binding (E-value: 4.1e-116, bitscore:
                     376.3, seeds: 400, tool: rule-based-clusters)"
                     /sec_met_domain="PP-binding (E-value: 9.7e-18, bitscore:
                     53.0, seeds: 164, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNNIEDIYSLSPMQQGMLFHTLYSPESEVYFEQLVCTLKGQLNLS
                     FFQQAWQKVVAKYPVLRSSFHWEEIEKPLQMVSQKVELPWMVYDWKHWDNLQQKEALES
                     FLKGDRTSGIELDQPPLMRFALIQLETDSYQFIWSHHHILFDGWSMQIILQEVFDLYES
                     YNRGESLQLKSCHPYREYISWLQQQDSSQAQKFWQQRLKGIEAPTPLVVDKLIDNKPQE
                     EAYQEIPFKLSFEITNQLQSLAQKHHLTLNNLVQGAWGLLLSRYSGETDIVFGATASGR
                     TSELPNIDTMVGLFINTLPVRLQISGKEELIPWLKALQSQQFEQEPYTYYSLADIQKNS
                     DIPPKMSLFESILVFENYPVDSSKNAPQRTLEITDIRCLERTNYPLTVVIIPNVELSGR
                     IVYDTRRFEAETIERMIGHLQTLLAGMANHPELRLSEFSLLTKAEEEQLILAENQNDSL
                     IKTIDYQCIHRLFEKQVEKTPNAIAIVYKDEQLTYQELNQRANQLAHYLQFLGIKLEDK
                     IGVCIERSPLMAIAILGILKAGGAYVPLDSAYPVERLAFMLEDVKCPILLTQTHLSNQL
                     PVDDIKQVINIESEWKNISQYSSDNLLTQVTPNNLAYIIYTSGSTGTPKGTEIPHRSFI
                     GFMFGVNYIKLGADNIWLQHSSISWDALTLELWTPLLYGGRCVLYPDNITTPENLSKII
                     KEEGVNILWLTCALFNLIIDTMPEALLEVKQLIIGGESLSVSHVRRALNLLPQTQIING
                     YGPSECTVFTACYVIPKQLDQNVNSIPIGKPIGDRRVYLLDQNLQRVPIAVPGEVYIGG
                     KSVARGYLNQPILTHEKFIDNPFVDGDTLYKTGDLVRRLSDENLEFLGRIDNQVKIRGF
                     RIELGEIETVLTNYSEIREAIVTIREDQPGDKSLVAYIVPHNHQLTTRDLRNFLSQKLP
                     NYMIPNAFVFLDKFPLTPNGKINRLGLPAPNISQQNLGIEFVAPRTSTERELVTIWTEV
                     LQLTKVGIYDNFFELGGHSLLATQLISRLKETFEIEFPFRYLFENPTISQLAEKVVNQQ
                     IELAEGDEFAQILGEIDELSEDEVAQQLFL"
     aSDomain        6510..6587
                     /aSDomain="NRPS-COM_Nterm"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_apnB_NRPS-COM_Nterm.1"
                     /evalue="3.20E-18"
                     /label="apnB_NRPS-COM_Nterm.1"
                     /locus_tag="apnB"
                     /protein_end="27"
                     /protein_start="1"
                     /score="56.6"
                     /tool="antismash"
                     /translation="NNIEDIYSLSPMQQGMLFHTLYSPES"
     aSDomain        6519..7421
                     /aSDomain="Condensation"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_apnB_Condensation_DCL.1"
                     /domain_subtypes="Condensation_DCL"
                     /evalue="7.50E-118"
                     /label="apnB_Condensation_DCL.1"
                     /locus_tag="apnB"
                     /protein_end="305"
                     /protein_start="4"
                     /score="384.8"
                     /tool="antismash"
                     /translation="EDIYSLSPMQQGMLFHTLYSPESEVYFEQLVCTLKGQLNLSFFQQ
                     AWQKVVAKYPVLRSSFHWEEIEKPLQMVSQKVELPWMVYDWKHWDNLQQKEALESFLKG
                     DRTSGIELDQPPLMRFALIQLETDSYQFIWSHHHILFDGWSMQIILQEVFDLYESYNRG
                     ESLQLKSCHPYREYISWLQQQDSSQAQKFWQQRLKGIEAPTPLVVDKLIDNKPQEEAYQ
                     EIPFKLSFEITNQLQSLAQKHHLTLNNLVQGAWGLLLSRYSGETDIVFGATASGRTSEL
                     PNIDTMVGLFINTLPVRLQI"
     aSModule        6519..9638
                     /complete
                     /domains="nrpspksdomains_apnB_Condensation_DCL.1"
                     /domains="nrpspksdomains_apnB_AMP-binding.1"
                     /domains="nrpspksdomains_apnB_PCP.1"
                     /locus_tags="apnB"
                     /monomer_pairings="Val -> Val"
                     /tool="antismash"
                     /type="nrps"
     CDS_motif       6528..6566
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_apnB_0001"
                     /evalue="3.20E-05"
                     /label="C1_dual_004-017"
                     /locus_tag="apnB"
                     /protein_end="20"
                     /protein_start="7"
                     /score="16.6"
                     /tool="antismash"
                     /translation="YSLSPMQQGMLFH"
     CDS_motif       6591..6707
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_apnB_0002"
                     /evalue="2.70E-17"
                     /label="C2_DCL_024-062"
                     /locus_tag="apnB"
                     /protein_end="67"
                     /protein_start="28"
                     /score="55.0"
                     /tool="antismash"
                     /translation="VYFEQLVCTLKGQLNLSFFQQAWQKVVAKYPVLRSSFHW"
     CDS_motif       6924..6989
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_apnB_0003"
                     /evalue="2.20E-11"
                     /label="C3_DCL_135-156"
                     /locus_tag="apnB"
                     /protein_end="161"
                     /protein_start="139"
                     /score="36.1"
                     /tool="antismash"
                     /translation="HHHILFDGWSMQIILQEVFDLY"
     CDS_motif       7035..7073
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_apnB_0004"
                     /evalue="4.70E-04"
                     /label="C4_DCL_171-183"
                     /locus_tag="apnB"
                     /protein_end="189"
                     /protein_start="176"
                     /score="12.6"
                     /tool="antismash"
                     /translation="PYREYISWLQQQD"
     CDS_motif       7317..7412
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_apnB_0005"
                     /evalue="4.30E-19"
                     /label="C5_DCL_263-294"
                     /locus_tag="apnB"
                     /protein_end="302"
                     /protein_start="270"
                     /score="60.9"
                     /tool="antismash"
                     /translation="DIVFGATASGRTSELPNIDTMVGLFINTLPVR"
     CDS_motif       7401..7463
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_apnB_0006"
                     /evalue="2.60E-01"
                     /label="C2_dual_024-063"
                     /locus_tag="apnB"
                     /protein_end="319"
                     /protein_start="298"
                     /score="3.9"
                     /tool="antismash"
                     /translation="LPVRLQISGKEELIPWLKALQ"
     CDS_motif       7461..7583
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_apnB_0007"
                     /evalue="3.10E-19"
                     /label="C67_DCL_14fromHMM"
                     /locus_tag="apnB"
                     /protein_end="359"
                     /protein_start="318"
                     /score="61.4"
                     /tool="antismash"
                     /translation="QSQQFEQEPYTYYSLADIQKNSDIPPKMSLFESILVFENYP"
     aSDomain        7917..9113
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_apnB_AMP-binding.1"
                     /evalue="2.00E-109"
                     /label="apnB_AMP-binding.1"
                     /locus_tag="apnB"
                     /protein_end="869"
                     /protein_start="470"
                     /score="357.7"
                     /specificity="substrate consensus: Val"
                     /tool="antismash"
                     /translation="FEKQVEKTPNAIAIVYKDEQLTYQELNQRANQLAHYLQFLGIKLE
                     DKIGVCIERSPLMAIAILGILKAGGAYVPLDSAYPVERLAFMLEDVKCPILLTQTHLSN
                     QLPVDDIKQVINIESEWKNISQYSSDNLLTQVTPNNLAYIIYTSGSTGTPKGTEIPHRS
                     FIGFMFGVNYIKLGADNIWLQHSSISWDALTLELWTPLLYGGRCVLYPDNITTPENLSK
                     IIKEEGVNILWLTCALFNLIIDTMPEALLEVKQLIIGGESLSVSHVRRALNLLPQTQII
                     NGYGPSECTVFTACYVIPKQLDQNVNSIPIGKPIGDRRVYLLDQNLQRVPIAVPGEVYI
                     GGKSVARGYLNQPILTHEKFIDNPFVDGDTLYKTGDLVRRLSDENLEFLGRIDNQVKIR
                     "
     CDS_motif       8103..8144
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_apnB_0008"
                     /evalue="3.10E-06"
                     /label="NRPS-A_a2"
                     /locus_tag="apnB"
                     /protein_end="546"
                     /protein_start="532"
                     /score="20.1"
                     /tool="antismash"
                     /translation="LGILKAGGAYVPLD"
     CDS_motif       8340..8399
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_apnB_0009"
                     /evalue="3.90E-09"
                     /label="NRPS-A_a3"
                     /locus_tag="apnB"
                     /protein_end="631"
                     /protein_start="611"
                     /score="28.6"
                     /tool="antismash"
                     /translation="AYIIYTSGSTGTPKGTEIPH"
     CDS_motif       8907..8996
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_apnB_0010"
                     /evalue="2.30E-13"
                     /label="NRPS-A_a6"
                     /locus_tag="apnB"
                     /protein_end="830"
                     /protein_start="800"
                     /score="42.3"
                     /tool="antismash"
                     /translation="PIAVPGEVYIGGKSVARGYLNQPILTHEKF"
     CDS_motif       9078..9143
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_apnB_0011"
                     /evalue="9.00E-13"
                     /label="NRPS-A_a8"
                     /locus_tag="apnB"
                     /protein_end="879"
                     /protein_start="857"
                     /score="40.0"
                     /tool="antismash"
                     /translation="FLGRIDNQVKIRGFRIELGEIE"
     aSDomain        9441..9638
                     /aSDomain="PCP"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_apnB_PCP.1"
                     /evalue="5.40E-27"
                     /label="apnB_PCP.1"
                     /locus_tag="apnB"
                     /protein_end="1044"
                     /protein_start="978"
                     /score="85.7"
                     /tool="antismash"
                     /translation="ERELVTIWTEVLQLTKVGIYDNFFELGGHSLLATQLISRLKETFE
                     IEFPFRYLFENPTISQLAEKV"
     gene            9882..17606
                     /gene="apnC"
     CDS             9882..17606
                     /NRPS_PKS="Domain: Condensation_LCL (48-348). E-value:
                     5.4e-113. Score: 368.8. Matches aSDomain:
                     nrpspksdomains_apnC_Condensation_LCL.1"
                     /NRPS_PKS="Domain: AMP-binding (512-906). E-value:
                     1.6e-115. Score: 377.8. Matches aSDomain:
                     nrpspksdomains_apnC_AMP-binding.1"
                     /NRPS_PKS="Domain: PCP (1012-1081). E-value: 1.2e-27.
                     Score: 87.8. Matches aSDomain: nrpspksdomains_apnC_PCP.1"
                     /NRPS_PKS="Domain: Condensation_LCL (1097-1400). E-value:
                     1.5e-110. Score: 360.7. Matches aSDomain:
                     nrpspksdomains_apnC_Condensation_LCL.2"
                     /NRPS_PKS="Domain: AMP-binding (1566-1960). E-value:
                     2.8e-116. Score: 380.3. Matches aSDomain:
                     nrpspksdomains_apnC_AMP-binding.2"
                     /NRPS_PKS="Domain: nMT (2052-2270). E-value: 8.3e-93.
                     Score: 302.6. Matches aSDomain: nrpspksdomains_apnC_nMT.1"
                     /NRPS_PKS="Domain: PCP (2484-2551). E-value: 5.9e-25.
                     Score: 79.2. Matches aSDomain: nrpspksdomains_apnC_PCP.2"
                     /codon_start=1
                     /gene="apnC"
                     /gene_functions="biosynthetic (rule-based-clusters) NRPS:
                     Condensation"
                     /gene_functions="biosynthetic (rule-based-clusters) NRPS:
                     AMP-binding"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1127:condensation domain-containing protein (Score:
                     377.9; E-value: 1.4e-114)"
                     /gene_kind="biosynthetic"
                     /note="nonribosomal peptide synthetase; C-A1-T-C-A2(Nmt)T;
                     A1,A2: activation of homotyrosine"
                     /product="ApnC"
                     /protein_id="ABV79987.1"
                     /sec_met_domain="Condensation (E-value: 6.7e-82, bitscore:
                     263.3, seeds: 42, tool: rule-based-clusters)"
                     /sec_met_domain="AMP-binding (E-value: 6.5e-124, bitscore:
                     402.0, seeds: 400, tool: rule-based-clusters)"
                     /sec_met_domain="PP-binding (E-value: 4.1e-18, bitscore:
                     54.3, seeds: 164, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSDLLKRLENLSPEKRELVLQKLKQQQSKTSNNQKKQKLSLIPVP
                     REGDIPLSFAQTRLWFLAQFDQENSPYHVPIFWQIKGSLNLNALEQAIAEIIDRHEVLR
                     TTFSVVNESPVQVINPPYQLSIPVINLEGETENIKLEKARQLATEELQTSFDLSISPLL
                     RVKLLKINPRFHILLLVIHHIIFDGWSVDLFRQELSTLYSSFSLNKPASLPKLALQYAD
                     FAHWQRQWLQGEILETQLNYWRQQLKNAPPLLEFPIDKPRPSLQTYEGSSQSIHLNLTL
                     TQQLKGLSQTSGTTLFMTLLTAFTVLLYRYSEQEDIVIGTAIANRNRQELEPLMGFFVN
                     TLALRTNLQGHLTFLELLQQVKDRTLESYDHQDLPFEKLIDELHIERSLSNHPLFQVFF
                     TLQNEAKETLELPELTISNFDWENKITLFDLGLICRETPQGLIAELEYRTDLFAAKTIQ
                     GIVEHLEILLHGIVDNPQQSINTLPLLTESNQKQLEIWNQTDSNYFQDKTLIDLFEEQV
                     NKTPDKTALVFEQTSLTYQELNQKANQLAHYLRENYQIEPDSLIGICTERSLEMVIGLL
                     GVLKAGAAYVPIDSDYPEDRIRFILENSKISVLLTQSFVQDKLSLSYLKSLSKFIDLDQ
                     FDYDLFPNYNLTVQSKPNHLAYVIYTSGSTGQPKGVMIEHQSIVNLCLNWGKLFHVNPQ
                     SRLLQFGSFSFDLSIGEIATNLSHGACLYLAGKETLLPTQTLVNFLETNQITHSFLSPS
                     ALSILPQANLSHLENITVGGEACSSEVVEKWANQRRLFNCYGPTETTVTATFSPCEANG
                     QKPNIGKPLDNIRAYILDRNQQILPPAIPGELCIAGVCLARGYLNRPDLTAEKFVEVNL
                     LGKTERIYKTGDLAKCGDDGNLEFLGRIDQQVKLRGFRIELGEIEAVLLEHPVVKEAVV
                     NLYETENNQQLVAYIIPQEKQRDVRDELKSLLKSRLPNYMIPSQIMILETLPLTPNGKL
                     DKKALPIPDLKIFTDGEMPVIPTEELLASLWQDLLQIKSVGRRDNFFELGGHSLLATQL
                     VTRIRNSFGVELAVRKVFEQSILAELATAIEQENRAIALPPLNPQPPQEPKVLSFAQSR
                     LWFMAQLEGDGTSLTYNMPSALQLEGNLNLEALRNSFEYLLSRHTILRTSFPLQSGEPQ
                     IFVHNTEEISVLEILNLQELDPQSQAKTVQELIDSDAQYPFDLSKGPLFKAKLLQLNPE
                     KNVLLLNMHHIISDGWSMGVFKNEWEQAYNAFTAGNTPNLAPLPIQYSDYAVWQRYWLT
                     GEVLENQENYWKKQLKDAPKLLDLPTDYPRPAKPTYQGGREEYRLSQELTEKLKNLSQK
                     QGVSLFMTLFTAFSILLSRYSRQEDLCIGTGIANRTHSYTEKSLGFFVNTLILRSQIKS
                     EQSFSKLLQKSRQICLDAYASQDIPFEYLVEKLQPERTLSYNPLYQVVIVLQNTEKSGK
                     NVSLTGLKIESLEQNYPFAKVDLLLDLAERDGQLDCMWEYATDLFETSTIERMAEQFEV
                     LLQGIVSNPQQSINSLPLLTETNQQELQLWNQTGTPYCQDKTLVDLFEEQVKKNPDNLA
                     LVFEQHSLTYQQLNEKANQLAHYLLKHYSIKPDTLISICVERSLEMIIGMLGIFKAGSA
                     YVPIDPNYPSDRIRLILEDCEATVLLTQSNLKDQLFLAQGLQSDQVLCLDEDKFAQYPI
                     NNPTVKSKPNNLAYVIYTSGSTGRPKGVMVEHQSIVNLCLNWGKLFHVKPQSRLLQFGS
                     FSFDLSIGEIATNLSHGACLYLAQKETLLPTQTLVNFLQTNKITHSFLSPSALSVLPQA
                     NLSHLENITVGGEVCSTEVIEKWANQRRLFNCYGPTETTVTATLSLCQANGQKPNIGKP
                     LDNIRVYILDDNQQLLPPGMPGELSIAGVGLARGYLNRPDLTAEKFIEVNLWGKTERIY
                     KTGDLAKWRTDGNLEFLGRIDQQVKLRGFRIELGEIETSLAQHPNIKESVVILREDLGF
                     EPRLVAYIVPSEMGKDSEVEQLAGQQVELWQSIFDDGYYQQDTEIDDPTLNFTGWNDSY
                     TGQPYAKTEMEEWRDKTVEQILELSPKRVWEIGCGTGMLLFKIAPHCQTFIGTDFSTKA
                     LQYVQENLTSQNLEKKVKLKQSPANQFEGITPQSYDLVILNSVIQYFPSVDYLLAVLDG
                     VINSIETGGKILIGDVRNFKLLEAFHTAVEFYRADDDLSIKELRQRIRNSLRTEEELLI
                     DPNLFIYLRQKYPRISQVQIELKRGYNQTEMNRFRYDVILYLDQPQTQPLVTEWQWLNW
                     EVEQLSLEKIEHILETQVPDLLGIENIPNIRLISEMVLLEKIPEFEGTAKQLKAILSQM
                     EIGINPEVLRTLTEDLPYTPFIQYSDRKFSTYQVIFQRNTTYPFSQPRFALKQTLNSLS
                     WQDYANQPLTVNPNSIDPVLIKQWRDFLGQTLPDYMIPSHFIQQSKLPITPNGKIDRKA
                     LPAPEIFIVSTDIELPQTTTELTLAAIWSKLLKYEGISRQDNFFYLGGHSLLATQLISR
                     IRDQFQIELSVSKLFEYPVLKELASYLDTCLWVNASEDSQPLDLDEEEIEL"
     aSDomain        10026..10925
                     /aSDomain="Condensation"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_apnC_Condensation_LCL.1"
                     /domain_subtypes="Condensation_LCL"
                     /evalue="5.40E-113"
                     /label="apnC_Condensation_LCL.1"
                     /locus_tag="apnC"
                     /protein_end="348"
                     /protein_start="48"
                     /score="368.8"
                     /tool="antismash"
                     /translation="DIPLSFAQTRLWFLAQFDQENSPYHVPIFWQIKGSLNLNALEQAI
                     AEIIDRHEVLRTTFSVVNESPVQVINPPYQLSIPVINLEGETENIKLEKARQLATEELQ
                     TSFDLSISPLLRVKLLKINPRFHILLLVIHHIIFDGWSVDLFRQELSTLYSSFSLNKPA
                     SLPKLALQYADFAHWQRQWLQGEILETQLNYWRQQLKNAPPLLEFPIDKPRPSLQTYEG
                     SSQSIHLNLTLTQQLKGLSQTSGTTLFMTLLTAFTVLLYRYSEQEDIVIGTAIANRNRQ
                     ELEPLMGFFVNTLALRTNL"
     aSModule        10026..13124
                     /complete
                     /domains="nrpspksdomains_apnC_Condensation_LCL.1"
                     /domains="nrpspksdomains_apnC_AMP-binding.1"
                     /domains="nrpspksdomains_apnC_PCP.1"
                     /locus_tags="apnC"
                     /monomer_pairings="X -> X"
                     /tool="antismash"
                     /type="nrps"
     CDS_motif       10038..10067
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_apnC_0001"
                     /evalue="2.80E-02"
                     /label="C1_LCL_004-017"
                     /locus_tag="apnC"
                     /protein_end="62"
                     /protein_start="52"
                     /score="7.5"
                     /tool="antismash"
                     /translation="SFAQTRLWFL"
     CDS_motif       10092..10202
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_apnC_0002"
                     /evalue="6.40E-16"
                     /label="C2_LCL_024-062"
                     /locus_tag="apnC"
                     /protein_end="107"
                     /protein_start="70"
                     /score="50.7"
                     /tool="antismash"
                     /translation="PYHVPIFWQIKGSLNLNALEQAIAEIIDRHEVLRTTF"
     CDS_motif       10422..10487
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_apnC_0003"
                     /evalue="1.20E-10"
                     /label="C3_LCL_132-143"
                     /locus_tag="apnC"
                     /protein_end="202"
                     /protein_start="180"
                     /score="33.8"
                     /tool="antismash"
                     /translation="IHHIIFDGWSVDLFRQELSTLY"
     CDS_motif       10536..10574
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_apnC_0004"
                     /evalue="1.00E-05"
                     /label="C4_LCL_164-176"
                     /locus_tag="apnC"
                     /protein_end="231"
                     /protein_start="218"
                     /score="18.0"
                     /tool="antismash"
                     /translation="QYADFAHWQRQWL"
     CDS_motif       10827..10916
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_apnC_0005"
                     /evalue="4.00E-16"
                     /label="C5_LCL_267-296"
                     /locus_tag="apnC"
                     /protein_end="345"
                     /protein_start="315"
                     /score="51.3"
                     /tool="antismash"
                     /translation="DIVIGTAIANRNRQELEPLMGFFVNTLALR"
     CDS_motif       10965..11084
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_apnC_0006"
                     /evalue="1.40E-19"
                     /label="C67_LCL_14fromHMM"
                     /locus_tag="apnC"
                     /protein_end="401"
                     /protein_start="361"
                     /score="62.5"
                     /tool="antismash"
                     /translation="KDRTLESYDHQDLPFEKLIDELHIERSLSNHPLFQVFFTL"
     aSDomain        11418..12599
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_apnC_AMP-binding.1"
                     /evalue="1.60E-115"
                     /label="apnC_AMP-binding.1"
                     /locus_tag="apnC"
                     /protein_end="906"
                     /protein_start="512"
                     /score="377.8"
                     /specificity="substrate consensus: X"
                     /tool="antismash"
                     /translation="FEEQVNKTPDKTALVFEQTSLTYQELNQKANQLAHYLRENYQIEP
                     DSLIGICTERSLEMVIGLLGVLKAGAAYVPIDSDYPEDRIRFILENSKISVLLTQSFVQ
                     DKLSLSYLKSLSKFIDLDQFDYDLFPNYNLTVQSKPNHLAYVIYTSGSTGQPKGVMIEH
                     QSIVNLCLNWGKLFHVNPQSRLLQFGSFSFDLSIGEIATNLSHGACLYLAGKETLLPTQ
                     TLVNFLETNQITHSFLSPSALSILPQANLSHLENITVGGEACSSEVVEKWANQRRLFNC
                     YGPTETTVTATFSPCEANGQKPNIGKPLDNIRAYILDRNQQILPPAIPGELCIAGVCLA
                     RGYLNRPDLTAEKFVEVNLLGKTERIYKTGDLAKCGDDGNLEFLGRIDQQVKLR"
     CDS_motif       11607..11648
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_apnC_0007"
                     /evalue="8.70E-06"
                     /label="NRPS-A_a2"
                     /locus_tag="apnC"
                     /protein_end="589"
                     /protein_start="575"
                     /score="18.8"
                     /tool="antismash"
                     /translation="LGVLKAGAAYVPID"
     CDS_motif       11847..11906
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_apnC_0008"
                     /evalue="2.90E-11"
                     /label="NRPS-A_a3"
                     /locus_tag="apnC"
                     /protein_end="675"
                     /protein_start="655"
                     /score="35.0"
                     /tool="antismash"
                     /translation="AYVIYTSGSTGQPKGVMIEH"
     CDS_motif       12261..12287
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_apnC_0009"
                     /evalue="4.90E-02"
                     /label="NRPS-A_a5"
                     /locus_tag="apnC"
                     /protein_end="802"
                     /protein_start="793"
                     /score="6.8"
                     /tool="antismash"
                     /translation="YGPTETTVT"
     CDS_motif       12390..12479
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_apnC_0010"
                     /evalue="9.60E-16"
                     /label="NRPS-A_a6"
                     /locus_tag="apnC"
                     /protein_end="866"
                     /protein_start="836"
                     /score="49.9"
                     /tool="antismash"
                     /translation="PPAIPGELCIAGVCLARGYLNRPDLTAEKF"
     CDS_motif       12564..12629
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_apnC_0011"
                     /evalue="1.00E-11"
                     /label="NRPS-A_a8"
                     /locus_tag="apnC"
                     /protein_end="916"
                     /protein_start="894"
                     /score="36.7"
                     /tool="antismash"
                     /translation="FLGRIDQQVKLRGFRIELGEIE"
     CDS_motif       12840..12866
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_apnC_0012"
                     /evalue="2.50E+00"
                     /label="NRPS-A_a10"
                     /locus_tag="apnC"
                     /protein_end="995"
                     /protein_start="986"
                     /score="2.0"
                     /tool="antismash"
                     /translation="GKLDKKALP"
     aSDomain        12918..13124
                     /aSDomain="PCP"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_apnC_PCP.1"
                     /evalue="1.20E-27"
                     /label="apnC_PCP.1"
                     /locus_tag="apnC"
                     /protein_end="1081"
                     /protein_start="1012"
                     /score="87.8"
                     /tool="antismash"
                     /translation="EELLASLWQDLLQIKSVGRRDNFFELGGHSLLATQLVTRIRNSFG
                     VELAVRKVFEQSILAELATAIEQE"
     aSDomain        13173..14081
                     /aSDomain="Condensation"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_apnC_Condensation_LCL.2"
                     /domain_subtypes="Condensation_LCL"
                     /evalue="1.50E-110"
                     /label="apnC_Condensation_LCL.2"
                     /locus_tag="apnC"
                     /protein_end="1400"
                     /protein_start="1097"
                     /score="360.7"
                     /tool="antismash"
                     /translation="PKVLSFAQSRLWFMAQLEGDGTSLTYNMPSALQLEGNLNLEALRN
                     SFEYLLSRHTILRTSFPLQSGEPQIFVHNTEEISVLEILNLQELDPQSQAKTVQELIDS
                     DAQYPFDLSKGPLFKAKLLQLNPEKNVLLLNMHHIISDGWSMGVFKNEWEQAYNAFTAG
                     NTPNLAPLPIQYSDYAVWQRYWLTGEVLENQENYWKKQLKDAPKLLDLPTDYPRPAKPT
                     YQGGREEYRLSQELTEKLKNLSQKQGVSLFMTLFTAFSILLSRYSRQEDLCIGTGIANR
                     THSYTEKSLGFFVNTLILRSQI"
     aSModule        13173..17534
                     /complete
                     /domains="nrpspksdomains_apnC_Condensation_LCL.2"
                     /domains="nrpspksdomains_apnC_AMP-binding.2"
                     /domains="nrpspksdomains_apnC_nMT.1"
                     /domains="nrpspksdomains_apnC_PCP.2"
                     /locus_tags="apnC"
                     /monomer_pairings="X -> NMe-X"
                     /tool="antismash"
                     /type="nrps"
     CDS_motif       13185..13214
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_apnC_0013"
                     /evalue="4.50E-02"
                     /label="C1_LCL_004-017"
                     /locus_tag="apnC"
                     /protein_end="1111"
                     /protein_start="1101"
                     /score="6.9"
                     /tool="antismash"
                     /translation="SFAQSRLWFM"
     CDS_motif       13245..13358
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_apnC_0014"
                     /evalue="5.20E-15"
                     /label="C2_LCL_024-062"
                     /locus_tag="apnC"
                     /protein_end="1159"
                     /protein_start="1121"
                     /score="47.8"
                     /tool="antismash"
                     /translation="TYNMPSALQLEGNLNLEALRNSFEYLLSRHTILRTSFP"
     CDS_motif       13578..13643
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_apnC_0015"
                     /evalue="2.70E-10"
                     /label="C3_LCL_132-143"
                     /locus_tag="apnC"
                     /protein_end="1254"
                     /protein_start="1232"
                     /score="32.7"
                     /tool="antismash"
                     /translation="MHHIISDGWSMGVFKNEWEQAY"
     CDS_motif       13692..13730
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_apnC_0016"
                     /evalue="1.50E-04"
                     /label="C4_LCL_164-176"
                     /locus_tag="apnC"
                     /protein_end="1283"
                     /protein_start="1270"
                     /score="14.4"
                     /tool="antismash"
                     /translation="QYSDYAVWQRYWL"
     CDS_motif       13983..14072
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_apnC_0017"
                     /evalue="2.30E-10"
                     /label="C5_LCL_267-296"
                     /locus_tag="apnC"
                     /protein_end="1397"
                     /protein_start="1367"
                     /score="32.9"
                     /tool="antismash"
                     /translation="DLCIGTGIANRTHSYTEKSLGFFVNTLILR"
     CDS_motif       14121..14237
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_apnC_0018"
                     /evalue="3.00E-19"
                     /label="C67_LCL_14fromHMM"
                     /locus_tag="apnC"
                     /protein_end="1452"
                     /protein_start="1413"
                     /score="61.4"
                     /tool="antismash"
                     /translation="RQICLDAYASQDIPFEYLVEKLQPERTLSYNPLYQVVIV"
     aSDomain        14580..15761
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_apnC_AMP-binding.2"
                     /evalue="2.80E-116"
                     /label="apnC_AMP-binding.2"
                     /locus_tag="apnC"
                     /protein_end="1960"
                     /protein_start="1566"
                     /score="380.3"
                     /specificity="substrate consensus: X"
                     /tool="antismash"
                     /translation="FEEQVKKNPDNLALVFEQHSLTYQQLNEKANQLAHYLLKHYSIKP
                     DTLISICVERSLEMIIGMLGIFKAGSAYVPIDPNYPSDRIRLILEDCEATVLLTQSNLK
                     DQLFLAQGLQSDQVLCLDEDKFAQYPINNPTVKSKPNNLAYVIYTSGSTGRPKGVMVEH
                     QSIVNLCLNWGKLFHVKPQSRLLQFGSFSFDLSIGEIATNLSHGACLYLAQKETLLPTQ
                     TLVNFLQTNKITHSFLSPSALSVLPQANLSHLENITVGGEVCSTEVIEKWANQRRLFNC
                     YGPTETTVTATLSLCQANGQKPNIGKPLDNIRVYILDDNQQLLPPGMPGELSIAGVGLA
                     RGYLNRPDLTAEKFIEVNLWGKTERIYKTGDLAKWRTDGNLEFLGRIDQQVKLR"
     CDS_motif       14769..14810
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_apnC_0019"
                     /evalue="3.20E-04"
                     /label="NRPS-A_a2"
                     /locus_tag="apnC"
                     /protein_end="1643"
                     /protein_start="1629"
                     /score="14.1"
                     /tool="antismash"
                     /translation="LGIFKAGSAYVPID"
     CDS_motif       15009..15068
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_apnC_0020"
                     /evalue="2.10E-11"
                     /label="NRPS-A_a3"
                     /locus_tag="apnC"
                     /protein_end="1729"
                     /protein_start="1709"
                     /score="35.4"
                     /tool="antismash"
                     /translation="AYVIYTSGSTGRPKGVMVEH"
     CDS_motif       15423..15449
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_apnC_0021"
                     /evalue="4.90E-02"
                     /label="NRPS-A_a5"
                     /locus_tag="apnC"
                     /protein_end="1856"
                     /protein_start="1847"
                     /score="6.8"
                     /tool="antismash"
                     /translation="YGPTETTVT"
     CDS_motif       15552..15641
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_apnC_0022"
                     /evalue="3.90E-16"
                     /label="NRPS-A_a6"
                     /locus_tag="apnC"
                     /protein_end="1920"
                     /protein_start="1890"
                     /score="51.1"
                     /tool="antismash"
                     /translation="PPGMPGELSIAGVGLARGYLNRPDLTAEKF"
     CDS_motif       15726..15791
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_apnC_0023"
                     /evalue="1.00E-11"
                     /label="NRPS-A_a8"
                     /locus_tag="apnC"
                     /protein_end="1970"
                     /protein_start="1948"
                     /score="36.7"
                     /tool="antismash"
                     /translation="FLGRIDQQVKLRGFRIELGEIE"
     aSDomain        16038..16691
                     /aSDomain="MT"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_apnC_nMT.1"
                     /domain_subtypes="nMT"
                     /evalue="8.30E-93"
                     /label="apnC_nMT.1"
                     /locus_tag="apnC"
                     /protein_end="2270"
                     /protein_start="2052"
                     /score="302.6"
                     /tool="antismash"
                     /translation="GQPYAKTEMEEWRDKTVEQILELSPKRVWEIGCGTGMLLFKIAPH
                     CQTFIGTDFSTKALQYVQENLTSQNLEKKVKLKQSPANQFEGITPQSYDLVILNSVIQY
                     FPSVDYLLAVLDGVINSIETGGKILIGDVRNFKLLEAFHTAVEFYRADDDLSIKELRQR
                     IRNSLRTEEELLIDPNLFIYLRQKYPRISQVQIELKRGYNQTEMNRFRYDVILYL"
     CDS_motif       17253..17279
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_apnC_0024"
                     /evalue="1.50E-01"
                     /label="NRPS-A_a10"
                     /locus_tag="apnC"
                     /protein_end="2466"
                     /protein_start="2457"
                     /score="5.2"
                     /tool="antismash"
                     /translation="GKIDRKALP"
     aSDomain        17334..17534
                     /aSDomain="PCP"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_apnC_PCP.2"
                     /evalue="5.90E-25"
                     /label="apnC_PCP.2"
                     /locus_tag="apnC"
                     /protein_end="2551"
                     /protein_start="2484"
                     /score="79.2"
                     /tool="antismash"
                     /translation="ELTLAAIWSKLLKYEGISRQDNFFYLGGHSLLATQLISRIRDQFQ
                     IELSVSKLFEYPVLKELASYLD"
     gene            17603..21865
                     /gene="apnD"
     CDS             17603..21865
                     /NRPS_PKS="Domain: Condensation_LCL (79-378). E-value:
                     3.9e-114. Score: 372.5. Matches aSDomain:
                     nrpspksdomains_apnD_Condensation_LCL.1"
                     /NRPS_PKS="Domain: AMP-binding (542-944). E-value: 6e-113.
                     Score: 369.4. Matches aSDomain:
                     nrpspksdomains_apnD_AMP-binding.1"
                     /NRPS_PKS="Domain: PCP (1049-1117). E-value: 1.5e-25.
                     Score: 81.0. Matches aSDomain: nrpspksdomains_apnD_PCP.1"
                     /NRPS_PKS="Domain: Thioesterase (1137-1394). E-value:
                     9.5e-31. Score: 99.8. Matches aSDomain:
                     nrpspksdomains_apnD_Thioesterase.1"
                     /codon_start=1
                     /gene="apnD"
                     /gene_functions="biosynthetic (rule-based-clusters) NRPS:
                     Condensation"
                     /gene_functions="biosynthetic (rule-based-clusters) NRPS:
                     AMP-binding"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1127:condensation domain-containing protein (Score:
                     394.7; E-value: 1e-119)"
                     /gene_kind="biosynthetic"
                     /note="nonribosomal peptide synthetase; C-A-T-Te;
                     activation of isoleucine"
                     /product="ApnD"
                     /protein_id="ABV79988.1"
                     /sec_met_domain="Condensation (E-value: 6e-83, bitscore:
                     266.7, seeds: 42, tool: rule-based-clusters)"
                     /sec_met_domain="AMP-binding (E-value: 4.6e-119, bitscore:
                     386.0, seeds: 400, tool: rule-based-clusters)"
                     /sec_met_domain="PP-binding (E-value: 2.9e-18, bitscore:
                     54.7, seeds: 164, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSNDQQIINLMGRLRELGCRISADGDKLRLRKTKNDIPAELIQQI
                     KINKTEILAFLNTAKDQVVTSQKDIPKLPTNALKQLSFAQQRLWFLGQMENSNATYNMP
                     MGLQLEGKLNVHALSESFAYVINRHESLRMYFPTVEGQPQIRIKKIENFNFLSIQDLSN
                     LDQLTQSVTVETLINNHVQEPFNLKTGPLFKAKLLQLKDNQFILLLNMHHISSDGWSMG
                     IFIRELRHAYLAFSQGQKPSLEPLPIQYSDFATWQRNWLQGEVLETQINYWKHQLKDAP
                     PRLELPTDYPRPPIQSYRGSHYSQTLTPELTGQLNSLSQQEGVSLYMLLLAVFNLLLSR
                     YSRQNDLCIGSPIANRPHRQTEGLIGFFANTLVLRNQIKSEQSFQEFLQQTRQTCLEAY
                     HHQDIPFEFLVEQLKPVRSLSYNPIFQVIFAVENNDSEALNLPELKIEWLDSSYPFAKF
                     DLSLLALESDGQLNCTWEYATDLFETITIQRMAEHWEVLLQQIVTNPQQKISNLSWLTK
                     ADQKQLELWNQTNTNYPQDKTLVDLFEEQVNKTPGNIALVFEEQSLTYQELNQKANQLA
                     HYLRENYQIEPDSLIGICIEPSLEMIVGLLGILKSGSAYVPIDPNYPESRINYIISDSK
                     ISILLTQSVIKDKFLLSQGKNLDHLICLDKCDFELKSKDNLTVKNQPNNLAYIIYTSGS
                     TGKPKGVAVNHQAISRLVLKTNYIQIMPEDRVAQAANIAFDAATFEIWGALLNGAKVII
                     IPKSILLSPSEFAASIQSQEVSVLFLTTALFNQLAALFPETFSSLRYLLFGGEAVDPKW
                     VQEVLDKGSPQNLLHVYGPTENTTFSSWYLVEKSPKNAITIPIGKPISNTRIYILDQYL
                     QPVPVGIPGELCIAGVGLAIAYLNRPDLTDEKFIEVNLFGKIERIYKTGDLAKWGDDGN
                     LEFLGRIDHQIKLRGFRIELGEIESVLLEHPAVKEAIVNLHKTENNQQLVAYVTGELID
                     DLSQQLKQHLKTYLPDYMIPSQIIRLDEFPLTPNGKIDRQALPHPNHESHSLYEAPRNT
                     IEQQLTEIWSLILEYEKISIHDNFFDLGGHSILAIKLLNEIQKSFNKELSLTSLFQNPT
                     IAQLAQQLSQFEAQPSISDLLVLQASGQKTPIFCVAGSNGHAFYFRDLAMNFADEHPVY
                     GLETPGRDGSHPLPISVEDHASSLIATLRQKQPKGPYILTGYSSGCSVALEMAFQLEQQ
                     GETISLLGIFDAGLVANPDYITQRSDLDWIWNMIERIEAVKGISLGLNYEQLAAQSDDQ
                     NRWDLAAEALYHHNVLPEHSTLSLLKTNLEVMKRVTLNYADYQPNFVISAPIVLFRAQD
                     VKEIVVQEHQAMSHYEQSDWGWQPYSNKAVQVVSVPGNHGQMLYEPNVKILADQLKKSI
                     QEHFNQPETESKALLADL"
     aSDomain        17840..18736
                     /aSDomain="Condensation"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_apnD_Condensation_LCL.1"
                     /domain_subtypes="Condensation_LCL"
                     /evalue="3.90E-114"
                     /label="apnD_Condensation_LCL.1"
                     /locus_tag="apnD"
                     /protein_end="378"
                     /protein_start="79"
                     /score="372.5"
                     /tool="antismash"
                     /translation="QLSFAQQRLWFLGQMENSNATYNMPMGLQLEGKLNVHALSESFAY
                     VINRHESLRMYFPTVEGQPQIRIKKIENFNFLSIQDLSNLDQLTQSVTVETLINNHVQE
                     PFNLKTGPLFKAKLLQLKDNQFILLLNMHHISSDGWSMGIFIRELRHAYLAFSQGQKPS
                     LEPLPIQYSDFATWQRNWLQGEVLETQINYWKHQLKDAPPRLELPTDYPRPPIQSYRGS
                     HYSQTLTPELTGQLNSLSQQEGVSLYMLLLAVFNLLLSRYSRQNDLCIGSPIANRPHRQ
                     TEGLIGFFANTLVLRNQI"
     aSModule        17840..21784
                     /complete
                     /domains="nrpspksdomains_apnD_Condensation_LCL.1"
                     /domains="nrpspksdomains_apnD_AMP-binding.1"
                     /domains="nrpspksdomains_apnD_PCP.1"
                     /domains="nrpspksdomains_apnD_Thioesterase.1"
                     /final_module
                     /locus_tags="apnD"
                     /monomer_pairings="Ile -> Ile"
                     /tool="antismash"
                     /type="nrps"
     CDS_motif       17846..17875
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_apnD_0001"
                     /evalue="4.30E-03"
                     /label="C1_LCL_004-017"
                     /locus_tag="apnD"
                     /protein_end="91"
                     /protein_start="81"
                     /score="9.7"
                     /tool="antismash"
                     /translation="SFAQQRLWFL"
     CDS_motif       17897..18013
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_apnD_0002"
                     /evalue="2.70E-14"
                     /label="C2_LCL_024-062"
                     /locus_tag="apnD"
                     /protein_end="137"
                     /protein_start="98"
                     /score="45.5"
                     /tool="antismash"
                     /translation="ATYNMPMGLQLEGKLNVHALSESFAYVINRHESLRMYFP"
     CDS_motif       18233..18298
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_apnD_0003"
                     /evalue="5.30E-11"
                     /label="C3_LCL_132-143"
                     /locus_tag="apnD"
                     /protein_end="232"
                     /protein_start="210"
                     /score="34.9"
                     /tool="antismash"
                     /translation="MHHISSDGWSMGIFIRELRHAY"
     CDS_motif       18347..18385
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_apnD_0004"
                     /evalue="3.70E-06"
                     /label="C4_LCL_164-176"
                     /locus_tag="apnD"
                     /protein_end="261"
                     /protein_start="248"
                     /score="19.3"
                     /tool="antismash"
                     /translation="QYSDFATWQRNWL"
     CDS_motif       18638..18727
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_apnD_0005"
                     /evalue="8.70E-17"
                     /label="C5_LCL_267-296"
                     /locus_tag="apnD"
                     /protein_end="375"
                     /protein_start="345"
                     /score="53.4"
                     /tool="antismash"
                     /translation="DLCIGSPIANRPHRQTEGLIGFFANTLVLR"
     CDS_motif       18776..18892
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_apnD_0006"
                     /evalue="4.50E-21"
                     /label="C67_LCL_14fromHMM"
                     /locus_tag="apnD"
                     /protein_end="430"
                     /protein_start="391"
                     /score="67.3"
                     /tool="antismash"
                     /translation="RQTCLEAYHHQDIPFEFLVEQLKPVRSLSYNPIFQVIFA"
     aSDomain        19229..20434
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_apnD_AMP-binding.1"
                     /evalue="6.00E-113"
                     /label="apnD_AMP-binding.1"
                     /locus_tag="apnD"
                     /protein_end="944"
                     /protein_start="542"
                     /score="369.4"
                     /specificity="substrate consensus: Ile"
                     /tool="antismash"
                     /translation="FEEQVNKTPGNIALVFEEQSLTYQELNQKANQLAHYLRENYQIEP
                     DSLIGICIEPSLEMIVGLLGILKSGSAYVPIDPNYPESRINYIISDSKISILLTQSVIK
                     DKFLLSQGKNLDHLICLDKCDFELKSKDNLTVKNQPNNLAYIIYTSGSTGKPKGVAVNH
                     QAISRLVLKTNYIQIMPEDRVAQAANIAFDAATFEIWGALLNGAKVIIIPKSILLSPSE
                     FAASIQSQEVSVLFLTTALFNQLAALFPETFSSLRYLLFGGEAVDPKWVQEVLDKGSPQ
                     NLLHVYGPTENTTFSSWYLVEKSPKNAITIPIGKPISNTRIYILDQYLQPVPVGIPGEL
                     CIAGVGLAIAYLNRPDLTDEKFIEVNLFGKIERIYKTGDLAKWGDDGNLEFLGRIDHQI
                     KLR"
     CDS_motif       19418..19459
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_apnD_0007"
                     /evalue="2.10E-04"
                     /label="NRPS-A_a2"
                     /locus_tag="apnD"
                     /protein_end="619"
                     /protein_start="605"
                     /score="14.7"
                     /tool="antismash"
                     /translation="LGILKSGSAYVPID"
     CDS_motif       19658..19717
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_apnD_0008"
                     /evalue="2.00E-10"
                     /label="NRPS-A_a3"
                     /locus_tag="apnD"
                     /protein_end="705"
                     /protein_start="685"
                     /score="32.5"
                     /tool="antismash"
                     /translation="AYIIYTSGSTGKPKGVAVNH"
     CDS_motif       20225..20314
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_apnD_0009"
                     /evalue="2.90E-14"
                     /label="NRPS-A_a6"
                     /locus_tag="apnD"
                     /protein_end="904"
                     /protein_start="874"
                     /score="45.1"
                     /tool="antismash"
                     /translation="PVGIPGELCIAGVGLAIAYLNRPDLTDEKF"
     CDS_motif       20399..20464
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_apnD_0010"
                     /evalue="6.10E-12"
                     /label="NRPS-A_a8"
                     /locus_tag="apnD"
                     /protein_end="954"
                     /protein_start="932"
                     /score="37.4"
                     /tool="antismash"
                     /translation="FLGRIDHQIKLRGFRIELGEIE"
     aSDomain        20750..20953
                     /aSDomain="PCP"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_apnD_PCP.1"
                     /evalue="1.50E-25"
                     /label="apnD_PCP.1"
                     /locus_tag="apnD"
                     /protein_end="1117"
                     /protein_start="1049"
                     /score="81.0"
                     /tool="antismash"
                     /translation="EQQLTEIWSLILEYEKISIHDNFFDLGGHSILAIKLLNEIQKSFN
                     KELSLTSLFQNPTIAQLAQQLSQ"
     aSDomain        21014..21784
                     /aSDomain="Thioesterase"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_apnD_Thioesterase.1"
                     /evalue="9.50E-31"
                     /label="apnD_Thioesterase.1"
                     /locus_tag="apnD"
                     /protein_end="1394"
                     /protein_start="1137"
                     /score="99.8"
                     /tool="antismash"
                     /translation="PIFCVAGSNGHAFYFRDLAMNFADEHPVYGLETPGRDGSHPLPIS
                     VEDHASSLIATLRQKQPKGPYILTGYSSGCSVALEMAFQLEQQGETISLLGIFDAGLVA
                     NPDYITQRSDLDWIWNMIERIEAVKGISLGLNYEQLAAQSDDQNRWDLAAEALYHHNVL
                     PEHSTLSLLKTNLEVMKRVTLNYADYQPNFVISAPIVLFRAQDVKEIVVQEHQAMSHYE
                     QSDWGWQPYSNKAVQVVSVPGNHGQMLYEPNVKIL"
     CDS_motif       21194..21268
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_apnD_0011"
                     /evalue="2.10E-10"
                     /label="NRPS-te1"
                     /locus_tag="apnD"
                     /protein_end="1222"
                     /protein_start="1197"
                     /score="33.0"
                     /tool="antismash"
                     /translation="QPKGPYILTGYSSGCSVALEMAFQL"
     gene            21913..23949
                     /gene="apnE"
     CDS             21913..23949
                     /codon_start=1
                     /gene="apnE"
                     /gene_functions="transport (smcogs) SMCOG1000:ABC
                     transporter ATP-binding protein (Score: 107.4; E-value:
                     1.6e-32)"
                     /gene_kind="transport"
                     /note="ABC transporter"
                     /product="ApnE"
                     /protein_id="ABV79989.1"
                     /transl_table=11
                     /translation="MQSQHTPKQSQKNSDSNLNFLEFWNKLKLVLGAYWYPMEADGRVF
                     SEVIKSWGMLILLLSLIIGLVAVSAFNSFVLRQLVNVIDEKNLSGFTNNLSILIVSFVF
                     ITLLTGLSKFVREKMALDWYEWLNNYMLQKYFSNRAYYKINFDSNIDNPDQRLTQEIKP
                     IAKTTLSFFATCVEKILEMIVFFVILWQISKTIGVVLIIYTTIGNLIAFYLSQEFNKIN
                     QEELEVEANYNYAVTHVRNHAESIAFFQGEDQEFNILKKRFSSLIQTALQKINWERSKN
                     FFDRGYQSIINVFPFLIVAPLYIRDEIDFGQVNQASLAANFFATALGTLITEFATSGRL
                     SSYIERLVNFSETLETITQQAEGVSTIKSIEENRLAFEDVTLQTPNYEKVIVENLTIEL
                     APEQGLLIVGPSGRGKSSLLRAIASLWNSGTGRLIRPPGKEILFLPQRPYIILGTLREQ
                     LLYPNVDRQVSDQELSEVLQQVNLQDVLTRVGGFDQEVPWENILSLGEQQRLAFARILV
                     TRPHFVILDESTSALDLINEKNLYQQLKETKTTFISVGHRESLFDYHQWVLELSPDSGW
                     QLLTVQDYQRQKAKEIINIPLDNAQITIDNLSSNESPTQPIPEIAVLTDKFEGFSHKEM
                     EVLTNYSIGTIRSKASLGKSITGNDGFTYRYNKDYRVSKWLRV"
ORIGIN
        1 atgttcaagc aatctatcca ccagttattt gaaacccaag ttgaacgcgc accagaagca
       61 gtggccgtcc tttcagaaca agggcaattg acctatgagg aattaaatac taaagcgaat
      121 caactagccc attatttgcg aaccctgggg gttaagtccg agacattggt gggactttgt
      181 gttgatcgtt ccctagagat gattattggc ttattggcta ttcttaaggc ggggggagcc
      241 tatgtgccgc tcgatccaac ttatcccagg gaaagattga cctacatggt gcaggatgct
      301 caaatatccg tgttggtcac gcaaacgcaa tggtctaact taatttccga ctatgaagga
      361 caggtagttt gtttagatag tcaatgggca aaaattgcca gttgtagtca agagaatctg
      421 gttaatacgg taaatcctga aaatttagcc tatgtcatct atacatcggg atcaacggga
      481 aaacccaagg gggtaatgat tgaacaccaa tccttggtaa acttcactaa actagcgatc
      541 gctcaatacc agataactaa acgcgatcgc actcttcaat ttgtctctat cagttttgat
      601 gtggccgcag aggaaatcta tgttactctt tgttctggtg ctaccttaat cttacgaact
      661 gaagaaatga tcagttctat tccttcattt gttcaaaaat cccaagattg gcaaataact
      721 gtttggagct tacccaccgc ttactggcat ttattagtca atgaattagt taagagtaaa
      781 atagcattac cagacagctt gcgattagtc attatcggcg gagaaagagt tcaaccagaa
      841 ttggtgagaa tgtggtttaa aaatgtagga aattttcctg aattaattaa tgcctatggc
      901 cccacagaag ggacaattgc ggtaagcctt tgtcgtctat cccaactagc agaaagtcaa
      961 cgcaacagga cagaaattcc tattggaaag agtttaggag aaaatatttc agtttacgtt
     1021 ttagatgaaa ccttaaaaac cgtttctcct gaaacaccag gagaaattta tatcgggggt
     1081 actgcggttg ccaggggtta tttgaatcgt ccagaattaa ctgctcaaaa atttattcaa
     1141 gctcccttta gcccctcaga aagattatat aaaaccggag atttaggaag gtatttggcc
     1201 gacggtaatt tagagtattt aggaagagtc gatcatcaag ttaaaatcaa cggttttaga
     1261 gttgaattag gagaaattga aaccgtttta cttcaacatc atcaagtcgc tcaagccgtt
     1321 gttattgatc gagaagatac tctgggaaat aaaagattag ttgcctatct tattccccat
     1381 tcaaaagagg aaaatctaac agaaactctg caacaatttc tgaaggatca gcttccgagc
     1441 tatatgattc ctgcgacttt tgttgtatta aatgagttgc cccttagtcc caatggaaaa
     1501 attgatcgta aagctttacc cgtaccagat tatgacggga acgagcgtca aactcccttt
     1561 attgcccctc gtaatcaaca agaagaaaaa ttagcaaaaa tttggcatca agtatttgga
     1621 ttagaaaaaa ttggggtcaa tgacaacttt tttcacttgg ggggacattc cctaattgcc
     1681 acacaaattt tatctcgaat acgggatatt tttgagattg aagtttcctt taaaaaattg
     1741 ttggagaatc ccacaattgg agatttaagt caaacaatta cagagcaaca gcaagataaa
     1801 aaaacaacta gctttaaaac aatcaagcct attgcacggg acggttattt gcctgtttct
     1861 tttgctcaag aaagggttta ttttattgaa caattagccc cctcgatcac cgcctatcaa
     1921 tttcaagaaa gtttacgcat taaaggcttt ttagatgtat ctattttaga aaaaagtatc
     1981 agtgaaattc tacgtcgtca tgaaatattc cgcaccacat ttccctctgt agcggggaaa
     2041 ctggtacaag tcattcatcc acccgaaccc gttacaatac ccattattga cttacaaaat
     2101 atttccaaag ataaacagca agaagaggtt caaaaactga ctgagcaggc aatccacaaa
     2161 ccctttgata ttagtcaatt accgttaata cattggacat tgttaaaatt aaatgagcaa
     2221 gaatgggtgt taattcatgt ggaacatcac atggtacatg atggctggtc atttaattta
     2281 tttttaaagg aattagtcac cctttatcaa gcattttctc aaggaaaacc ttctccatta
     2341 agtgaacctt ccttacagtt tgtggacttt gctcattggc agcgagaatg gacgaaaaca
     2401 gaggaagcaa caacacaact caactattgg catcaaaaat tagcgggtat tcctcctcta
     2461 ttggaattac cctatgatcg tcctcggcca accgagcaaa cctatggggg cggaagggta
     2521 cgggtggatc ttcccttaga tatttgccaa ctcctgagaa gcctgggtcg tcaagagggg
     2581 gtaacgctct tcatgagtat gtttgcagtc tttgtcgcac agatttatcg ctatacaggc
     2641 caagaagaca tctgtgtggg ttctggagtg gctaaccgac ggttgcggga gacagaggga
     2701 cttattggca tgattgtcaa taatatcgtg cttcgtactg atgtttcggg aaatcccact
     2761 tttaaacaac tgttagagca agtacgtcaa gtcaccctag aaggctatgc caatgaggac
     2821 ttaccttttg ataaagtcgt cgaagtgtta aaacccgttc gtcatttaag ttataacccc
     2881 ttatttcagg tgatgtttag tttccatgat gctcagttac ctgatttgaa tttgcctgga
     2941 ttgagcatta aaccgaatga tgcccttgct aataattcgg caaaatttga cttagatatt
     3001 gtggttattc ctcgttctga gcaacgagtt ggacgtaatt ctaccgcaga aacaaaggga
     3061 attgaaaccg aaggaattac gatggtttgg gaatataata cgggactctt cgaggaatct
     3121 actatcaaca gaatggtcga agattatcaa accctattac aagaaatttt aacaaatccc
     3181 aaccaaagac tatctcaata ttccctgtta acggaacagc aaaaacatca gttattagtg
     3241 gaatggaata acactcaagc tgagtatccg aaagttaagg gaattcatca actctttgaa
     3301 gaacaagtca agaaaacacc agaggcgatc gcagttatat ttgaggataa atatctcagc
     3361 tatcaacaat taaacgaaca ggcaaaccaa cttgctcatt atctccaaac attaggagtt
     3421 gaagctgata acctagtggg gattttcctg gatcgttcct tagaaatgct cattggacta
     3481 ttgggaatac tcaaagcagg aggagcctat ctacccctag accccagcta tccagaagac
     3541 agattagcct atatggttaa tgatgctcaa gtttctattg tggttacttt ggaaaagtgg
     3601 gcaaatttaa caactcaaca ggcacttcaa tgggtttgtt tagatagtca aaaagatatt
     3661 attgctcaac aaagtagtaa taatatcaat gttgccatag aagagaaaaa tcttgcttat
     3721 gtcatctata catcaggctc tacgggacaa cccaaaggag tcttgattga acatcaatcc
     3781 ttgattaact ttaccaaaag tgcgatagaa aaatatgaaa taacggaaca agatacggtc
     3841 ttacaatttg cttccattaa ttttgatgct gcggctgaag aaatttatcc ctgtttaagt
     3901 tctgggggaa ccttagttct gagaacagaa gaaatgatga aatctgtctc agcatttata
     3961 caagaatctc agaaaaaaga agtaacaatt tgggatttac ccaccgctta ctggcattta
     4021 ttagtcagtg aaattattca agaaaatctc caattaccgc catctttgag actggtaatt
     4081 ttagggggtg agcgggtgtt accagaaagg gtaaaaatgt ggcaggaata cgtgggacaa
     4141 tatccccaat tagttaatag ttatggcccg acagaatcca ccgttgtctc taccctacac
     4201 tatctggaag aaagccctat taatcaagca gaaattccca tcggaaaacc cattaataac
     4261 gtccaagttt acatattaga tcaatactta caaccgatgc ccattggcgt acctggagaa
     4321 cttcatatcg ggggtttagg gatagcaagg gggtatttaa accgaccaga attaacggta
     4381 gaaaaattta tagataatcc ttttaaagca ggagaaaaac tctataaaac aggagattta
     4441 gtccgctata aattcaacgg taatttggaa tttttaggac gcattgactc tcaagttaaa
     4501 attcggggtt ttcgcattga attgactgaa attgaaacag tcttaaatca atattcatcc
     4561 atcaaacaat cggtagttat tgccagggaa gatagtccag ggattaagcg attagttgcc
     4621 tatatcgtag ggaataaaaa tcaaaacaaa atcgaagaaa ttcgctatta tcttaagcag
     4681 aaattaccgc cttatatggt tccctctgct ttcgttttcc tggaagaaat tcccatcact
     4741 actaatggaa aagttgacca tcgtgcctta cctattccag aaatgacttc ctcgttagcg
     4801 agtgagttca ctgctcctaa aacccccata gaagaacgtt taacagcaat ttgggctgag
     4861 gtcttaagac tggaaaaagt tagtatccat gataacttct ttgaactggg aggggattca
     4921 attattagta ttcagatgat ttccaaagcg aatcaaatgg gattacaatt aagtcctaag
     4981 caactttttc agtatcaaac tattgcagaa ttagctaccg ttgtcggaat agataagcaa
     5041 ataaaagcta atcaaggatt agtcacagga attatccctt taacgcccat tcaacattgg
     5101 ttgtttgagc aagatttacc tgatgttaat tactttaatc aatcagcatt aattgaagtt
     5161 acagcaacag taaacccaga acgattaaaa caagttatac aagcattatt gaatcatcat
     5221 gatgctttgc ggttgcatta tcttcaagaa ggtgaaagtc taactcaaat tagtgagaca
     5281 acaaaagatg caataccttt agaggtaatt gatttatcac aactgtctcc aagcgcacaa
     5341 aaaacagcaa ttatagccaa agatgaagaa actcaaagga gtctaaacct aaccacagga
     5401 gatattgtca aagttgtttt atttaactta ggaaatgaac aaccaagtca attactcatc
     5461 gtaattcatc acttagcgat cgatggaatt tcttggcgta ttttacttga agatttagct
     5521 acagcttatc aacaaattag tcaaagtcaa gaaattaaat taccactaaa aaccacttca
     5581 tttcaagatt ggtctaacca attagtcacc tatagtcaat ctgaaaaatt aaaacaagaa
     5641 agggattatt ggatatccca attaacaaaa gaaattgctt ctttacctat ggattattct
     5701 gggacaaaag agagtaatca gttaagttcg gcaaaagcca ttaacctatt tttaaatgaa
     5761 gaagaaactc gtggattatt gcaagatgtt cctggtgttt ataataccca aattaacgat
     5821 gtcttgttaa ctgctttatt ggaaagtttt agccaatgga caggagaaaa atctttaatt
     5881 gttgacttag aaggccatgg acgggaagat ttatttgaag taatagactt gtctcgtact
     5941 gttggttggt ttaccaccct atttccagtg cgactagaag gcagtaaaac gggacaactt
     6001 ccagaaacct taaaatcagt taaagagcaa ctgcgtcgtt tacccaatcg tggtataggt
     6061 catggtattt tgaagtattt gtctaaagat caagaggtta aaaagcaatt tcaggactta
     6121 ataaaagcac aagttagttt caattattta ggtcaatttg atcaggtact atcggcatca
     6181 ggagttttag gagaagtcaa agaatggaaa acggaacgaa gtcttgtggg aaaccgcagt
     6241 catttgttag aaattagtgg attaattcgt tcccagaaat tagaaatgca atttgtttat
     6301 agtgagaaag ttcatcaacg agagaccatt gaaagattgg caaatggatt tatgagcgtc
     6361 ttaaaaagtc taattattca ctgtcagtcg tccaaggata aaggttatac accatcagac
     6421 ttttctgctg ctcaagttag tcaagaacag ctagataaat tcctgtccaa aatcaatcaa
     6481 aagaaaggta aaacgaggta attttgatga acaacattga agatatttat tctctctctc
     6541 caatgcaaca aggtatgctc tttcataccc tttattcccc agagtctgag gtttattttg
     6601 agcagctagt ttgtactttg aaaggacaat taaatctttc attttttcaa caggcttggc
     6661 aaaaagttgt ggccaaatat cctgtgttaa gaagttcttt tcattgggaa gaaattgaaa
     6721 agcctctgca aatggtcagt cagaaagtag aattaccttg gatggtttat gactggaaac
     6781 attgggataa tttacaacaa aaagaagcgt tagagtcgtt tttgaaaggc gatcgcactt
     6841 cagggattga acttgatcaa ccacctttaa tgcgttttgc tttaatacag ttagaaaccg
     6901 acagttacca atttatttgg agtcatcatc atattctctt tgatggttgg tcaatgcaga
     6961 tcattcttca agaggttttt gatttatatg aaagttataa tcgaggtgaa tctttacaat
     7021 taaaatcctg tcatccctat cgggaatata ttagttggtt acagcaacaa gatagttctc
     7081 aagctcagaa gttttggcaa caaagactta aggggattga agcacctaca cctctggttg
     7141 ttgataaatt gattgataat aaaccccaag aagaggctta tcaagaaata ccttttaagt
     7201 tatcttttga gattacaaac caattacaat cattggcaca aaaacatcat ttaaccctta
     7261 ataatttagt gcaaggagct tggggtttac tgctttcccg ttatagtgga gaaacggata
     7321 ttgtttttgg cgcaacggca tctggacgca cgagtgagtt accaaatatt gatacaatgg
     7381 ttgggctatt tatcaatacc ttaccagtgc gattacaaat ttctgggaaa gaggaattaa
     7441 ttccttggtt aaaagcatta caaagtcagc aatttgaaca agaaccctat acttattatt
     7501 ccctagctga tattcagaaa aatagtgata ttccgcctaa aatgtcttta tttgaaagta
     7561 ttttggtatt tgaaaattat cccgtagatt cctcgaaaaa tgctccgcaa agaaccttag
     7621 aaattaccga tattcggtgt ttagaaagaa caaactatcc tttgacagtt gtgattattc
     7681 ctaatgtaga attatcagga agaattgtct atgatacccg tcgctttgaa gcggaaacga
     7741 ttgagcgtat gattggacat ttgcaaacct tattagcagg aatggcgaat catccagaac
     7801 tacgtctttc tgaattttca ttattaacta aagcggaaga agaacaatta atattggcag
     7861 aaaatcaaaa tgattccctg atcaaaacta ttgactatca atgtattcat cggttatttg
     7921 agaaacaggt agaaaagact cctaatgcga tcgcgatcgt ttataaagat gaacaattaa
     7981 cctatcaaga attaaaccaa agagctaatc aattagccca ttatttacaa tttctaggta
     8041 taaaattaga ggataaaata ggggtttgca ttgaaagatc acctttaatg gcgatcgcaa
     8101 ttttagggat tcttaaagca ggaggagctt atgttccttt agattctgct tatccagttg
     8161 aaagattagc tttcatgctc gaagatgtaa aatgccccat acttttaact caaactcatt
     8221 tatctaatca attaccagtt gatgatatta aacaggttat taatatcgaa tcagaatgga
     8281 aaaatattag tcaatattcc tctgacaatt tattaactca agttactccc aataacttag
     8341 cttatattat ttacacgtca ggttcaactg gaaccccgaa aggaacagaa attcctcatc
     8401 gtagcttcat cggttttatg tttggggtta attatattaa gctgggggct gacaatattt
     8461 ggctacaaca ttcttcaatt tcttgggatg ctttaacttt agaattgtgg acaccattgc
     8521 tttatggggg gcgttgtgtg ctttatccag acaatattac gactcctgaa aacttgagca
     8581 aaattatcaa agaagaaggg gttaatattc tctggctgac ttgtgcttta tttaacctaa
     8641 ttattgatac aatgccagaa gctttattag aagttaaaca attaataata ggaggagaat
     8701 ctttatctgt ttctcatgtt cgtcgtgctt taaatttatt accacaaaca caaattatta
     8761 atggttatgg cccttcagaa tgtactgtat ttaccgcttg ttatgtgatt ccaaaacaac
     8821 tcgatcaaaa tgtcaattca attcccattg gtaaaccgat tggagataga agagtttact
     8881 tacttgatca gaatttacaa cgagttccga tcgcggttcc tggggaagtt tacataggcg
     8941 gaaaaagtgt tgccaggggt tatttgaatc agccaatatt aactcacgaa aagtttattg
     9001 ataatccttt tgttgatgga gatactcttt ataaaacagg agatttagtg cgtcgtctga
     9061 gcgatgaaaa tctagaattt ttaggacgta ttgataatca ggtcaaaatt cgcggttttc
     9121 gcattgaatt aggggaaatt gagacggttt taactaatta ttctgaaata agggaagcga
     9181 ttgttacaat acgagaagat caacctggag ataaatcttt agttgcttat attgttcccc
     9241 ataatcatca attaactact cgtgatctca gaaattttct gagtcaaaag ttgcctaatt
     9301 atatgattcc gaatgctttt gtctttttag acaaatttcc tctcactcct aatggtaaaa
     9361 ttaatcgtct tggtttacct gctcccaata tttctcagca gaatttaggg attgaatttg
     9421 ttgctcctcg gacttctaca gaacgggaat tagtaacaat ttggactgag gttctacagt
     9481 tgacaaaagt aggaatatat gataattttt ttgaattagg aggtcattct ttactagcaa
     9541 ctcaactaat ttctcgatta aaagaaacct ttgaaattga gtttcctttc cgctacttat
     9601 ttgaaaatcc taccattagc caactagcag agaaagttgt taaccaacag attgaactag
     9661 cagaaggtga tgaatttgcg caaatcttag gggagattga cgagttatct gaagatgaag
     9721 tggcacaaca attattttta tgattttcaa gtcaaataat gttataatgg taggtaggaa
     9781 tgaggaatac aaaatgtgac cactaatggt aattctacat aacttctaaa agtctttctt
     9841 ttttgcttct atttttttaa aactaatctt ccataaatcc tatgagtgat ctgctaaaac
     9901 gtttagaaaa tctttctcct gaaaaacgag aattagtgct acaaaagctg aagcagcagc
     9961 aatcaaaaac aagtaataat caaaagaaac aaaaattatc attgattcct gtaccaagag
    10021 aaggagatat tcctctatct tttgctcaaa cgagactctg gtttttagct caatttgatc
    10081 aagaaaattc tccttatcat gtgcctattt tttggcaaat taagggaagt cttaatttaa
    10141 acgccctaga gcaagcgatc gcagaaatta ttgaccgtca tgaagtatta cggacgactt
    10201 tttctgtggt taatgagtct cctgtacagg ttattaatcc tccttatcag ttaagcatac
    10261 cagtaattaa tttagaggga gagacagaaa atattaaatt agagaaggcg cgacaattag
    10321 caaccgaaga actgcaaacc tcttttgact tatcaataag tcctttatta cgggtaaaat
    10381 tactcaaaat taaccctcga tttcatattt tattgttggt tattcatcac attatttttg
    10441 atggttggtc ggttgatcta ttccgtcaag aattatctac tctttatagc tctttttccc
    10501 taaataaacc tgcttctttg ccaaaattag ctcttcaata tgctgatttt gcccattggc
    10561 agcgacaatg gttacaggga gaaatactag aaacccaact taattattgg cggcaacagt
    10621 taaaaaatgc tccccctctc ttagaattcc ccattgataa acctcgtccc tctctacaaa
    10681 cctatgaggg ttctagtcaa tctatacatc tcaatctgac tttaacgcag caattgaagg
    10741 gattaagtca aacatcagga acaactctgt ttatgaccct tctaactgcc tttaccgtcc
    10801 tactttatcg ctatagtgaa caggaagata ttgtcattgg aacggcgatc gctaatcgaa
    10861 atcgtcaaga attagagcca ttaatgggct tttttgttaa cactttagct ttacgaacta
    10921 atttgcaagg tcatcttact tttttagaat tattgcaaca agttaaggat agaactctgg
    10981 aatcctatga tcatcaagac ttaccctttg agaaattaat tgatgaatta cacattgagc
    11041 gatcgctgag taatcatccc ttatttcaag tattttttac cctacagaat gaagctaaag
    11101 agaccttaga attgccagaa ttaactatca gtaattttga ttgggaaaac aaaataacgt
    11161 tatttgattt aggattaatt tgtcgagaaa ctccccaagg gttaatcgca gaattagaat
    11221 atcggacaga tttatttgca gccaaaacta ttcaaggaat agtagaacat ttagaaattt
    11281 tattacatgg aattgttgat aatcctcaac agtcaattaa tactttacct ttactaacag
    11341 aatctaatca aaaacaacta gaaatttgga atcaaacgga tagtaactat tttcaagata
    11401 aaactttaat tgatttattt gaagaacaag taaataaaac ccctgacaag acagcattgg
    11461 tctttgaaca gacaagttta acttatcaag aactaaatca aaaagctaat cagttggctc
    11521 attatttacg agaaaactat cagattgaac cagatagctt aattggcatt tgtaccgaac
    11581 gttcattaga gatggttatc ggtttattag gtgttttaaa agcgggtgct gcttatgttc
    11641 cgattgactc cgattatcca gaagatagaa ttagatttat tttagaaaat agtaaaattt
    11701 cagtcttatt aacccagagt tttgttcaag ataaattatc cctatcttac ttaaaatctt
    11761 taagtaagtt tattgattta gatcagtttg attatgactt atttcctaac tataatttaa
    11821 cagttcaaag taaacctaat cacctagctt atgtgattta tacttctggt tcaacaggac
    11881 aacctaaagg ggtaatgatt gaacaccaat caattgttaa tctttgctta aattggggca
    11941 aactatttca cgttaatccg caaagtcgtt tacttcaatt tgggtctttt agttttgatt
    12001 tatctattgg agaaattgcc actaatctta gtcatggtgc ttgtttatat ttagcaggaa
    12061 aagaaacatt actacccact caaaccttag taaactttct ggaaacgaac caaatcaccc
    12121 atagcttttt atctccttca gccctatcta ttttacctca agccaactta tcccatttag
    12181 aaaatataac ggttggaggt gaagcttgtt cttctgaagt cgtagaaaaa tgggcaaatc
    12241 aaagacgttt attcaactgc tatggcccta cagaaacgac ggtaacagcg acattttctc
    12301 cttgtgaagc aaatggtcaa aaacccaata ttggtaaacc attagataat attcgcgcct
    12361 atattttaga taggaatcag caaatcttac caccagcaat accaggagaa ttatgtattg
    12421 caggagtctg tttagcgagg ggttatttga atcgtccaga cttaacggct gagaaatttg
    12481 ttgaagttaa cctattagga aaaactgaac gaatttataa aacaggggat ttagcaaaat
    12541 gtggagatga tggaaatctg gaatttttgg gacgtattga ccagcaagta aaactgcgag
    12601 gatttcgcat tgaattaggg gaaattgaag cagttttgtt ggagcatcct gttgttaaag
    12661 aagctgttgt taacctatat gaaacagaaa ataatcagca attagtggct tatattatcc
    12721 cgcaagaaaa acagcgtgat gttagggatg aactgaaaag cttactgaaa agccgtttgc
    12781 caaattacat gattccaagt cagattatga tcttggaaac tcttccccta acccctaatg
    12841 gaaaattaga taaaaaagcc ctaccgatcc ctgatttaaa aatatttacc gatggcgaaa
    12901 tgcctgttat tcccacagaa gaattattag ccagtctatg gcaagatctc ttgcaaatca
    12961 agtctgtggg tcgtcgggat aacttctttg aattgggggg acattctcta ttagctaccc
    13021 aattagtcac ccgtattcgt aacagttttg gggtagaatt agccgttcgt aaagtatttg
    13081 aacagagtat tttagctgaa ttagcaacag caattgaaca agaaaatagg gcgatcgcct
    13141 tacctcctct caacccacag ccaccccagg aaccgaaagt gttatccttt gcccaatcaa
    13201 gactttggtt tatggcccaa ctggaaggag atgggacttc actcacctac aatatgccta
    13261 gtgcgctgca acttgagggt aacttaaatc tagaagcgtt gcgtaacagt tttgaatatc
    13321 ttctctcacg tcatactatt ctgcgtacct ccttccccct ccaatcagga gaaccgcaaa
    13381 tttttgtcca taatacggag gaaattagtg tactggaaat cctgaactta caagaacttg
    13441 atccccaatc tcaagccaaa acggtgcaag aactgattga tagtgatgct caatatccct
    13501 ttgatttaag caaaggccct ctatttaaag ccaaattact gcaattaaat ccagaaaaaa
    13561 acgttttact cttgaatatg caccatatta tcagtgatgg ctggtcaatg ggggtgttca
    13621 aaaacgaatg ggaacaagct tataatgcct ttactgctgg aaatacgccg aatttagccc
    13681 ccttgccgat tcaatatagt gattatgctg tttggcagcg ttattggtta actggggaag
    13741 tcttggaaaa tcaagaaaat tattggaaaa aacaactaaa agatgcccct aaattattag
    13801 atttacccac agattatcct cgtccagcaa aaccaactta tcaaggggga cgagaagaat
    13861 atagattgag tcaagaactc acggaaaaat taaaaaattt gagtcaaaaa cagggggtta
    13921 gtttatttat gaccctgttt actgcgttta gtattttact gtcccgttac agtcgccaag
    13981 aagatttatg tatcggcact ggtattgcca atcgtaccca tagttataca gaaaaatctc
    14041 tcggtttttt tgtcaatact ttaatcttgc gtagtcaaat taaatctgaa caaagcttta
    14101 gtaaattgct acaaaaaagc cgtcaaattt gtttagatgc ttatgctagt caggatattc
    14161 cttttgagta tttggtcgaa aaattacaac ccgaacgcac attaagttat aaccccttat
    14221 atcaagtggt tattgtgtta caaaacaccg aaaaatcagg aaaaaatgtg agtttaacag
    14281 ggcttaaaat tgaatcttta gaacaaaatt atccatttgc taaggtagat ttactattag
    14341 atttagcgga aagagatggc caactagatt gtatgtggga atatgccacc gatctctttg
    14401 aaacaagcac cattgaaaga atggcagaac agtttgaagt gttgctacag ggaattgtta
    14461 gtaacccaca acagtctatt aatagcttac ctttactgac agaaactaat cagcaagaat
    14521 tacaattatg gaatcaaaca gggactcctt attgccaaga caaaacctta gtagatttat
    14581 ttgaggaaca agtcaagaaa aatcctgata atttagcctt agtctttgaa caacacagtt
    14641 taacctatca acaactcaat gaaaaagcca atcaattagc tcattattta ctaaaacatt
    14701 actcgattaa accagacact ttaattagta tctgtgttga acgttcctta gaaatgatta
    14761 ttggaatgtt gggtattttt aaagcaggtt ctgcttatgt acccattgat cccaattatc
    14821 ccagcgatcg cattcgtcta atcttagaag attgtgaggc aacagtttta ttaactcaga
    14881 gtaaccttaa agatcaattg tttttagctc aggggcttca atctgatcaa gttttgtgtt
    14941 tagatgaaga taaatttgcc caatacccta ttaataatcc caccgttaaa agtaagccaa
    15001 ataatttagc ttatgtgatt tatacttctg gttcgacagg acgaccaaaa ggagtgatgg
    15061 ttgaacatca atcaattgtt aatctttgct taaattgggg caagctgttt cacgttaaac
    15121 cgcaaagtcg tttacttcaa tttgggtctt ttagttttga tttatccatt ggtgaaatcg
    15181 ctactaatct tagtcatggt gcttgtttat acttagccca aaaagaaaca ttgctaccca
    15241 ctcaaacctt agtaaacttt ctacaaacta acaaaataac ccatagcttt ttatcgcctt
    15301 cagccttatc cgttttacct caagccaact tatcccattt agaaaatata acagttgggg
    15361 gtgaagtttg ttctactgaa gtgatagaaa aatgggcaaa tcaaagacgt ttatttaact
    15421 gctatggccc tacagaaacg acggtaacag cgacactttc tctttgtcaa gcgaatggtc
    15481 aaaaacccaa tattggtaaa ccattagata atattcgggt ttatatttta gatgataatc
    15541 agcaactttt acccccagga atgccaggag aattatctat tgcaggagtt ggcttggcga
    15601 ggggatattt gaatcgtccc gacttaacgg ctgagaaatt tattgaggtt aacctatggg
    15661 gaaaaaccga acgaatttat aaaacaggag acttagctaa atggcgaact gatggcaatc
    15721 tggaattttt aggacgcatt gatcaacaag taaaactgcg tgggtttcgc attgaattag
    15781 gggaaattga aacttcatta gcccagcatc ctaacattaa agaatctgtt gtaatcttac
    15841 gagaagatct agggtttgaa ccccgtttgg tcgcctatat tgttcccagt gaaatgggaa
    15901 aagattcaga agtagaacaa ctggcagggc aacaagtaga actgtggcag agtatttttg
    15961 atgatggcta ctatcagcaa gatactgaaa ttgatgaccc cacacttaat tttacaggtt
    16021 ggaatgatag ctacacagga caaccttatg ctaagacaga gatggaagaa tggcgagaca
    16081 aaactgttga gcaaattcta gaattatcac ctaaacgagt ttgggaaatt ggttgtggaa
    16141 cagggatgtt attgtttaaa attgcgcccc attgtcaaac ctttatcggc acagattttt
    16201 caaccaaagc tttacagtat gttcaggaaa atttaacatc acaaaatctt gagaaaaagg
    16261 ttaaattaaa acagagtcca gcgaaccaat ttgagggaat taccccccaa agttatgact
    16321 tagttattct caattctgtg attcaatatt tcccctcagt tgattactta ttggctgttt
    16381 tagatggggt gatcaactct atagagacag gaggtaaaat cttaattggg gatgtgagaa
    16441 actttaaact tctagaggct tttcatacag ccgttgaatt ctatcgtgca gatgatgacc
    16501 tatccattaa agaattacgt caacgaatta gaaacagtct gaggacagaa gaagaattac
    16561 tgattgatcc caatctcttt atttacttaa gacaaaaata tcctcgtatt agtcaagtcc
    16621 aaatcgaatt aaaacggggt tataatcaga cagaaatgaa tcgttttcgt tacgatgtta
    16681 ttctatattt agatcaacct caaactcaac cattagttac agaatggcaa tggttgaact
    16741 gggaagttga acaactcagt ctagaaaaga ttgaacatat tttagaaact caagtacctg
    16801 atttgttagg gattgaaaat attcccaata ttcgtctgat ttcagaaatg gtattattgg
    16861 aaaaaattcc tgagtttgag ggaactgcta aacaattaaa agctatttta agccagatgg
    16921 aaattggtat caaccctgaa gtattgcgaa ccttaacgga ggacttaccc tatactccat
    16981 ttattcaata tagcgatcgc aaattttcca cttatcaagt catttttcaa cgcaatacaa
    17041 cctatccttt tagtcagcct cgttttgctt taaaacagac cttaaattcc ctatcttggc
    17101 aggattatgc aaatcaacct ttaaccgtta atcctaattc tattgatcca gttttaatta
    17161 agcagtggcg agatttttta gggcagactc tccctgacta tatgattcct agtcatttta
    17221 ttcaacagtc gaaattaccc ataactccca atggaaagat agaccgcaaa gccttaccag
    17281 cacctgaaat atttattgtc tcaacagata ttgaattacc tcaaacaacc acagaactca
    17341 ccctggccgc tatctggtca aaattgctta aatatgaagg aatttcccga caagataatt
    17401 tcttttactt aggagggcat tctttattag caactcaatt aattagccgt attcgggatc
    17461 aatttcaaat cgaattgtct gtaagtaaac tatttgaata tcccgttctc aaggaattag
    17521 caagctatct tgatacctgt ttatgggtta atgcttcaga agattctcaa cctttagatt
    17581 tagatgaaga ggaaattgaa ttatgagtaa tgatcaacaa attattaact taatgggacg
    17641 attacgggaa ctcggatgtc gcatttctgc tgatggagac aagttacgcc ttcggaaaac
    17701 aaaaaatgac attcctgctg agttaatcca acaaataaaa attaataaaa cagaaatttt
    17761 agctttttta aatacagcta aagatcaagt tgttacatct caaaaagata ttcctaaatt
    17821 acctacaaat gccttaaaac agctttcttt cgctcaacaa aggctttggt ttttagggca
    17881 aatggaaaac tctaatgcca cctataatat gcccatgggt ttacaattgg agggaaaact
    17941 taatgttcat gctctctctg agagtttcgc ctatgtcatc aatcgccatg aaagtttgcg
    18001 aatgtatttt ccgactgtag aagggcaacc ccaaattcgg attaaaaaga tagaaaattt
    18061 caattttttg agcatacaag atttaagcaa tcttgatcaa ctcactcagt ctgtaacggt
    18121 tgaaacatta attaataatc atgttcaaga accgtttaat ctcaagactg gccctttatt
    18181 taaagccaaa ttactacaat taaaagataa ccaatttatt ttgctgctaa atatgcacca
    18241 tatcagcagt gatggctggt caatgggtat ctttattcgt gaattacgtc atgcttatct
    18301 ggccttttcc caaggacaaa aaccaagcct tgaaccttta cccattcaat atagtgactt
    18361 tgccacttgg cagcgaaatt ggttgcaggg agaggtatta gaaactcaga ttaactattg
    18421 gaaacaccaa ctaaaagacg caccaccacg attagaatta cccacagatt atcctcgtcc
    18481 cccaatacaa agttatagag gttctcatta tagccagact ttaacccctg aattaactgg
    18541 gcaattaaac agcctcagtc aacaagaagg ggtaagttta tatatgctct tattggcagt
    18601 ttttaacctt ttactctccc gttatagccg ccaaaatgac ctatgtattg gttcacccat
    18661 tgccaatcgt ccccatcgtc aaactgaagg attaatcggt ttttttgcca atactttagt
    18721 gctgcgaaat caaattaaat cggaacaaag ttttcaagaa tttttacagc aaactcgtca
    18781 aacttgttta gaagcttatc atcatcagga tattcctttt gagtttcttg tcgaacaatt
    18841 aaagcctgtt cgtagcctta gctataatcc tatttttcaa gtaatatttg ctgtagaaaa
    18901 taatgacagt gaagctctca atttgccaga attaaagatt gaatggctag actcaagtta
    18961 tccctttgct aagtttgatt tatccctttt agctttagaa tctgatggtc aattaaattg
    19021 tacatgggaa tacgcaaccg atctatttga aacaataacc attcaacgaa tggcagaaca
    19081 ttgggaagtt ttgttacaac aaattgttac taacccacag caaaaaattt ctaacctatc
    19141 ttggctaaca aaagctgacc aaaaacaatt agaactttgg aatcaaacga atacaaatta
    19201 tcctcaagat aaaaccttag ttgatttatt tgaagaacaa gtaaataaaa cccctggcaa
    19261 tatagcatta gtctttgaag aacaaagttt aacttatcaa gaactaaatc aaaaagctaa
    19321 ccagttagct cattatttac gagaaaatta tcagattgaa ccagatagct taattggtat
    19381 ttgtatcgag ccttcgttgg aaatgattgt cgggttatta ggtattctta aatcagggtc
    19441 tgcttatgtt cccattgatc ccaactatcc tgaatcacga ataaattata taattagtga
    19501 tagtaaaatt tcaattttat taacgcaaag tgttattaaa gataaatttt tgttatctca
    19561 aggcaagaac cttgaccatt taatttgctt agataaatgt gattttgaac tcaaatcaaa
    19621 ggataactta actgtcaaaa atcagccgaa taatttggct tatataattt atacatctgg
    19681 ttcgacaggt aaacctaaag gggttgcggt aaatcatcaa gctatcagtc gcttggtatt
    19741 aaaaactaac tacatacaaa taatgcctga agacagagtt gctcaagcag caaatattgc
    19801 ttttgatgct gcgacctttg aaatttgggg cgcattactt aacggagcaa aggtcatcat
    19861 tattcctaaa tccatactgc tttcaccatc agaatttgct gctagtattc aatctcaaga
    19921 agttagtgta ttattcctaa caacagcctt gttcaatcag ttggctgcat tgtttccaga
    19981 aacatttagt tctctccgtt atctattatt tggtggggaa gcagttgatc caaaatgggt
    20041 acaagaagtc ttagacaaag gttcaccaca gaacttgctg cacgtctatg ggccaacaga
    20101 aaatacaacg ttttcttctt ggtatttggt cgagaaatca cctaaaaatg caataactat
    20161 tcctattgga aaacccataa gtaacaccag aatttatatt ttagaccaat atctgcaacc
    20221 tgttcctgtt ggtattccag gagaattatg tattgcagga gttgggttag cgatcgcgta
    20281 tttgaatcgt cctgacttaa cagatgagaa atttattgaa gttaatttat tcggaaaaat
    20341 agaacgaatt tataaaacag gggatttagc aaaatgggga gatgatggaa atctggaatt
    20401 tttaggacgc attgatcatc aaataaaatt gcgaggtttt cgcattgaat taggggaaat
    20461 tgagtcagtt ctattggaac atcctgccgt taaagaagca attgttaact tacataaaac
    20521 cgaaaataat cagcagttag tggcctatgt aacaggcgaa ctaattgatg atctttccca
    20581 acaattaaaa caacacctca aaacttattt acctgattat atgattccta gccaaattat
    20641 caggttagat gaatttccct taacccccaa tggcaaaatt gatcgtcaag ctttacccca
    20701 tcccaatcat gaatcccata gtctatatga agctcctcgt aacacaattg aacaacaatt
    20761 aaccgaaatt tggtctttaa tacttgaata tgaaaaaatt agcattcatg ataacttttt
    20821 tgatttaggc ggccattcaa tactagcgat taagctccta aatgagattc aaaaaagctt
    20881 taacaaagaa ctgtctttaa ccagtctgtt tcagaatccc accattgctc aattggcaca
    20941 acaactgtct caatttgagg cacaaccgtc catttctgac ttattagtat tgcaagcttc
    21001 gggacagaaa acccctatat tttgtgttgc tgggtctaat ggacacgcct tctattttcg
    21061 agatttagcc atgaattttg ccgatgaaca tcctgtttat ggactagaaa caccaggcag
    21121 ggacggttct catcctctcc cgatttcggt agaagatcat gccagttccc tgattgcaac
    21181 cttacgacaa aaacaaccga aagggcctta tatcttaaca ggatattcat caggttgttc
    21241 tgttgctttg gaaatggctt ttcaactaga acaacaagga gaaacaatca gtttattagg
    21301 aatatttgat gcgggactgg tggctaatcc tgattatatt acccaaagaa gcgacctaga
    21361 ttggatctgg aatatgattg aacggattga agctgttaaa gggatttctt tgggtcttaa
    21421 ctatgaacaa ttagcagccc aatccgatga tcaaaaccgt tgggatctgg cggcggaggc
    21481 tttatatcat cacaatgtgt tacccgaaca ttctacccta tctttgctca aaaccaatct
    21541 tgaggtgatg aaacgagtta ctcttaatta tgcggattac caacccaatt ttgtgatttc
    21601 tgcccctatt gttttatttc gcgcccaaga tgtcaaagaa attgtggtgc aagaacatca
    21661 agccatgtcc cattatgagc aatccgattg gggatggcaa ccttatagta acaaagctgt
    21721 gcaagtggtt tccgtaccag gaaatcatgg acaaatgctc tatgaaccca atgtcaaaat
    21781 tctggctgat caacttaaaa aatccataca agagcatttt aatcaacctg aaaccgaaag
    21841 caaagctttg cttgctgatc tttaatttaa tcaactaacc tattggaaaa ttcatttact
    21901 taatttataa ctatgcaatc acaacatact cctaaacaat cgcaaaaaaa ctctgattca
    21961 aatcttaatt ttctggaatt ttggaataag ctgaagttag ttcttggagc ctattggtat
    22021 ccaatggaag cagatggtag agttttttct gaggttatta aatcctgggg aatgttaata
    22081 cttttactat cattaatcat cggtttagtg gctgttagtg ccttcaatag ttttgttttg
    22141 cgtcaattgg ttaatgtaat tgatgagaaa aatttatctg ggtttacgaa caatctttct
    22201 attttgattg ttagctttgt gtttatcact ctcttgacgg gactttctaa gtttgtgaga
    22261 gagaaaatgg cccttgactg gtatgaatgg ctgaataatt atatgttgca gaaatatttt
    22321 agcaatcgtg cctattataa gattaacttt gactcaaaca ttgataatcc tgatcaacgt
    22381 ctaacccaag aaattaaacc catcgccaaa acaaccctca gtttttttgc aacttgtgtc
    22441 gagaaaatct tggaaatgat agtttttttc gtgattctct ggcagatttc taaaaccatt
    22501 ggagtggttt tgattattta taccactatt ggtaatttga ttgcctttta tttaagccaa
    22561 gaatttaata agattaatca agaagaactc gaagttgaag ccaattataa ttatgctgtt
    22621 acccatgttc gtaatcatgc tgaatctatt gctttttttc agggagaaga tcaagaattt
    22681 aatattctta aaaaacgatt tagttctttg attcaaactg ctttgcaaaa gattaattgg
    22741 gaaagaagta agaacttttt tgaccgaggc tatcagtcaa ttattaacgt ttttcccttt
    22801 ttaatcgtcg cccctttata tatcagagat gaaattgatt ttggacaggt aaatcaggct
    22861 agtttagcag ctaatttttt cgccacagct ttgggtacat tgatcactga atttgcaact
    22921 tcaggaagac tttctagtta tattgagcgt ttggtgaatt tttcagaaac cttagaaaca
    22981 attacccaac aagctgaggg tgtaagtacc attaaaagta ttgaagaaaa ccgtctcgct
    23041 tttgaggatg ttaccttaca aactcctaat tatgaaaaag taatcgttga aaatttaaca
    23101 attgagttag caccagaaca gggtttatta attgttggac cgagtggacg gggcaaaagt
    23161 tctcttttaa gagcgatcgc tagtttatgg aattcaggca ctggacgttt aatacgacca
    23221 ccaggaaaag aaatcctatt tctaccccag cgtccatata tcattctcgg aacattacgc
    23281 gaacaattac tttatccgaa tgtggatcgt caagtgagcg atcaagaact cagtgaagtt
    23341 ctacaacaag tgaatcttca agatgtgctt accagggtcg gaggctttga tcaagaagtc
    23401 ccttgggaaa atatattatc actaggggaa caacaacgtt tggcttttgc ccgaatatta
    23461 gtgacccgtc ctcattttgt tatcttagat gaatcaacta gtgctttgga tttgatcaat
    23521 gaaaagaatt tatatcaaca gttaaaagaa acaaaaacaa cctttattag tgtgggacat
    23581 cgggaaagtc tttttgatta ccaccaatgg gttttggaac tctcacccga ttctggttgg
    23641 caactgttaa ccgtacagga ttatcagcgg caaaaagcta aagaaattat caatattccc
    23701 cttgacaatg ctcaaatcac catagacaat ctttctagta atgaatcccc gactcagccc
    23761 atacctgaaa tagcggtatt aactgacaaa tttgagggat tttcccataa agaaatggag
    23821 gttttgacca actactcaat aggcactatc agaagtaaag ccagccttgg taagtctatt
    23881 actggcaatg acggctttac ctatcgctat aacaaagatt acagggtctc taagtggcta
    23941 agggtttag
//
