BGC0000302: anabaenopeptin biosynthetic gene cluster from Anabaena sp. 90
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
View antiSMASH-generated output
Download Cluster GenBank file
Download region SVG
Location: 1 - 36,200 nt. (total: 36,200 nt).
This entry is originally from NCBI GenBank GU174493.1.

Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset zoomreset view
zoomzoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
General
Compounds
Genes
Biosynthesis
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0000302
Short description anabaenopeptin biosynthetic gene cluster from Anabaena sp. 90
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: complete
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRPS (Type I)
Loci
GU174493.1
via Enzymatic assays
Compounds
  • anabaenopeptin
Species Anabaena sp. 90 [taxonomy]
References
Chemical products information
anabaenopeptin Evidence:
Copy SMILES
C42H62N10O9
Chemical database entries
PubCHEM
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • ACZ55945.1
  • aptA1
 745 - 7332 (+) non-ribosomal peptide synthetase
    copy AA seq
    copy Nt seq
    • ACZ55942.1
    • aptA2
    		 7422 - 13946 (+) non-ribosomal peptide synthetase
      copy AA seq
      copy Nt seq
      • ACZ55943.1
      • aptB
      		 14004 - 17213 (+) non-ribosomal peptide synthetase
        copy AA seq
        copy Nt seq
        • ACZ55944.1
        • aptC
        		 17408 - 25105 (+) non-ribosomal peptide synthetase
          copy AA seq
          copy Nt seq
          • ACZ55946.1
          • aptD
          		 25102 - 29313 (+) non-ribosomal peptide synthetase
            copy AA seq
            copy Nt seq
            • ACZ55947.1
            • aptE
            		 29356 - 30534 (+) hydroxymethylglutaryl-CoA lyase-like protein
              copy AA seq
              copy Nt seq
              • ACZ55948.1
              • aptF
              		 30943 - 33240 (+) ABC transporter
                copy AA seq
                copy Nt seq
                Biosynthesis information

                Biosynthetic modules

                Name
                A0
                Type
                nrps-type1
                Genes
                aptA1
                Substrates
                arginine, lysine (evidence: Structure-based inference [1])
                Integrated Monomers
                Domains
                adenylation
                Name
                A1
                Type
                nrps-type1
                Genes
                aptA1
                Substrates
                lysine (evidence: ATP-PPi exchange assay [1])
                Integrated Monomers
                Domains
                condensation (LCL), adenylation, epimerase
                Name
                B0
                Type
                nrps-type1
                Genes
                aptA2
                Substrates
                tyrosine (evidence: ATP-PPi exchange assay [1])
                Integrated Monomers
                Domains
                adenylation
                Name
                B1
                Type
                nrps-type1
                Genes
                aptA2
                Substrates
                lysine (evidence: ATP-PPi exchange assay [1])
                Integrated Monomers
                Domains
                condensation (LCL), adenylation, epimerase
                Name
                2
                Type
                nrps-type1
                Genes
                aptB
                Substrates
                valine (evidence: ATP-PPi exchange assay)
                Integrated Monomers
                Domains
                condensation (DCL), adenylation
                Name
                3
                Type
                nrps-type1
                Genes
                aptC
                Substrates
                homotyrosine, alanine, isoleucine, valine, leucine, tyrosine (evidence: ATP-PPi exchange assay [1])
                Integrated Monomers
                Domains
                condensation (LCL), adenylation
                Name
                4
                Type
                nrps-type1
                Genes
                aptC
                Substrates
                alanine (evidence: Structure-based inference [1])
                Integrated Monomers
                Domains
                condensation (LCL), adenylation, methyltransferase
                Name
                5
                Type
                nrps-type1
                Genes
                aptD
                Substrates
                phenylalanine (evidence: ATP-PPi exchange assay [1])
                Integrated Monomers
                Domains
                condensation (LCL), adenylation
                Annotation changelog

                Entry version: 4

                Date
                Changes
                Submitters
                Reviewers
                2022-10-07
                Update chemical activity to schema version 2.11
                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                Entry version: 3

                Date
                Changes
                Submitters
                Reviewers
                2022-09-15
                Corrected NRP module activity
                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                2022-09-15
                Updated NRP substrate specificities
                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                Entry version: 2

                Date
                Changes
                Submitters
                Reviewers
                2019-10-16
                Migrated from v1.4
                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                Entry version: 1

                Date
                Changes
                Submitters
                Reviewers
                2015-06-12
                Submitted
                • (ID: BAJIZJS2YANDM4M7JHS5DFUK)
                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                Detailed domain annotation
                Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
                A domain glossary is available here, and an explanation of the visualisation is available here.
                Selected features only
                Show module domains
                Similar known gene clusters from MIBiG 4.0
                Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
                Click on reference genes to show details of similarities to genes within the current region.
                Click on an accession to open that entry in the MiBIG database.