Genomic loci for this biosynthetic pathway

Cluster Type From To
The following clusters are from record BGC0000302.1:
Cluster 1NRP136200

BGC0000302, anabaenopeptin biosynthetic gene cluster from Anabaena sp. 90. Locus 1. Full MIBiG entry.

Chemical compounds

Compound: anabaenopeptin
PubChem ID: 44558924
SMILES string: Copy to clipboard
Molecular formula: C42H62N10O9
Average molecular mass: 851.019 Da
Molecular activity: Inhibitor
Molecular target: protease inhibitor

Class-specific details

Biosynthetic class(es):
NRP
Other (cyclic)
Thioesterase type:
Unknown
Release / cyclization type:
Hydrolysis

Nonribosomal peptide synthetases:
aptA1 (ACZ55945.1)
Module A0
A specificity: Arginine / Lysine
Evidence for specificity: None
C domain subtype: N/A
Module A1
A specificity: Lysine
Evidence for specificity: Activity assay
AA is epimerized
C domain subtype: LCL
aptA2 (ACZ55942.1)
Module B0
A specificity: Tyrosine
Evidence for specificity: Activity assay
C domain subtype: N/A
Module B1
A specificity: Lysine
Evidence for specificity: Activity assay
AA is epimerized
C domain subtype: LCL
aptB (ACZ55943.1)
Module 2
A specificity: Valine
Evidence for specificity: Activity assay
C domain subtype: DCL
aptC (ACZ55944.1)
Module 3
A specificity: Homotyrosine
Evidence for specificity: Activity assay
C domain subtype: LCL
Module 4
A specificity: N-Methyl-alanine
Evidence for specificity: None
C domain subtype: LCL
Scaffold-modifying domain: Methylation
aptD (ACZ55946.1)
Module 5
A specificity: Phenylalanine
Evidence for specificity: Activity assay
C domain subtype: LCL

Gene cluster description

anabaenopeptin (BGC0000302). Gene Cluster 1. Biosynthetic class = NRP. GenBank GU174493, positions 1-36200. Click on genes for more information.

Legend:

biosynthetic genes
transport-related genes
regulatory genes
other genes

Domain annotation

Homologous known gene clusters

General MIBiG information on this cluster

Complete gene cluster sequence?complete
Evidence for cluster-compound connection:Enzymatic assays
MIxS-compliance:Unknown
Contact for this cluster:David Fewer (University of Helsinki)

Literature references

1. Rouhiainen L et al. (2010) Two alternative starter modules for the non-ribosomal biosynthesis of specific anabaenopeptin variants in Anabaena (Cyanobacteria). Chem Biol 17(3):265-73. doi: 10.1016/j.chembiol.2010.01.017.