BGC0000303: anthramycin biosynthetic gene cluster from Streptomyces refuineus subsp. thermotolerans
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Location: 1 - 33,150 nt. (total: 33,150 nt).
This entry is originally from NCBI GenBank EU195114.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
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Gene details
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General
Compounds
Genes
Biosynthesis
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0000303
Short description anthramycin biosynthetic gene cluster from Streptomyces refuineus subsp. thermotolerans
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: unknown
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRPS (Type I)
Loci
EU195114.1
via
Compounds
  • anthramycin
Species Streptomyces refuineus subsp. thermotolerans [taxonomy]
References
Chemical products information
anthramycin Evidence:
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C16H17N3O4
Chemical database entries
NPAtlas
PubCHEM
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • ABW71832.1
 1 - 1860 (-) putative amidotransferase
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    • ABW71833.1
    		 1883 - 3385 (-) putative aldehyde dehydrogease
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      • ABW71834.1
      		 3382 - 4446 (-) putative alcohol dehydrogenase
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        • ABW71835.1
        		 4468 - 5700 (-) cytochrome P-450 hydroxylase
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          • ABW71836.1
          		 5697 - 6755 (-) methyltransferase
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            • ABW71837.1
            		 6789 - 8654 (-) hypothetical protein
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              • ABW71838.1
              		 8651 - 10114 (-) FAD oxidoreductase
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                • ABW71839.1
                		 10514 - 12808 (+) drug-resistance pump
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                  • ABW71840.1
                  		 12855 - 13625 (+) putative hydroxylase/glyoxylase
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                    • ABW71841.1
                    		 13654 - 14847 (+) transporter
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                      • ABW71842.1
                      		 14967 - 15236 (+) hypothetical protein
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                        • ABW71843.1
                        		 15320 - 15829 (+) putative L-DOPA 2,3-dioxygenase
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                          • ABW71844.1
                          		 15826 - 16734 (+) putative L-tyosine 3-hydroxylase
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                            • ABW71845.1
                            		 16731 - 17624 (+) hypothetical protein
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                              • ABW71846.1
                              		 17615 - 18445 (+) hypothetical protein
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                                • ABW71847.1
                                		 18442 - 19683 (+) putative kynureninase
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                                  • ABW71848.1
                                  		 19694 - 20479 (+) putative tryptophan 2,3-dioxygenase
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                                    • ABW71849.1
                                    		 20514 - 20690 (+) hypothetical protein
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                                      • ABW71850.1
                                      		 20687 - 21730 (+) putative aromatic C-methyltransferase
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                                        • ABW71851.1
                                        		 21723 - 22613 (+) putative aryl formamidase
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                                          • ABW71852.1
                                          		 22610 - 24412 (+) nonribosomal peptide synthetase
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                                            • ABW71853.1
                                            		 24414 - 28754 (+) nonribosomal peptide synthetase
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                                              • ABW71854.1
                                              		 28633 - 30135 (+) putative kynurenine 3-monooxygenase
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                                                • ABW71855.1
                                                		 30248 - 31684 (-) flavin-containing oxidoreductase
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                                                  • ABW71856.1
                                                  		 31715 - 32536 (-) putative regulator
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                                                    Biosynthesis information
                                                    Annotation changelog

                                                    Entry version: 4

                                                    Date
                                                    Changes
                                                    Submitters
                                                    Reviewers
                                                    2022-10-07
                                                    Update chemical activity to schema version 2.11
                                                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                    Entry version: 3

                                                    Date
                                                    Changes
                                                    Submitters
                                                    Reviewers
                                                    2022-09-15
                                                    Updated bioactivity data
                                                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                    Entry version: 2

                                                    Date
                                                    Changes
                                                    Submitters
                                                    Reviewers
                                                    2019-10-16
                                                    Migrated from v1.4
                                                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                    2019-10-16
                                                    Updated compound(s) information (NPAtlas curation)
                                                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                    Entry version: 1

                                                    Date
                                                    Changes
                                                    Submitters
                                                    Reviewers
                                                    2015-06-12
                                                    Submitted
                                                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                    Detailed domain annotation
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