BGC0000304: apicidin biosynthetic gene cluster from Fusarium incarnatum
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Location: 1 - 63,164 nt. (total: 63,164 nt).
This entry is originally from NCBI GenBank GQ331953.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
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Gene details
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General
Compounds
Genes
NRP
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0000304
Short description apicidin biosynthetic gene cluster from Fusarium incarnatum
Status Minimal annotation: no
A minimal annotation only contains information on the BGC loci and one or more linked chemical product(s)

Completeness: Unknown
Whether the loci encodes everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRP
Loci NCBI GenBank: GQ331953.1
Compounds
  • apicidin
Species Fusarium incarnatum [taxonomy]
References
Chemical products information
apicidin
Copy SMILES
C34H49N5O6
Chemical database entries
NPAtlas
PubCHEM
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • ACZ66248.1
  • aps2
 9934 - 11129 (+) APS2
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  • ACZ66249.1
  • aps3
 11170 - 12153 (-) APS3
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  • ACZ66250.1
  • aps4
 12703 - 14066 (-) APS4
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  • ACZ66251.1
  • aps5
 14493 - 19523 (+) APS5
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  • ACZ66252.1
  • aps6
 23702 - 24928 (+) APS6
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  • ACZ66253.1
  • aps7
 25175 - 26995 (-) APS7
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  • ACZ66254.1
  • aps8
 27326 - 29141 (+) APS8
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  • ACZ66255.1
  • aps9
 29500 - 31442 (+) APS9
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  • ACZ66256.1
  • aps10
 32219 - 32971 (-) APS10
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  • ACZ66257.1
  • aps11
 33385 - 35362 (-) APS11
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  • ACZ66258.1
  • aps1
 35951 - 51438 (+) APS1
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NRP-specific information
Subclass N/A
Cyclic? no
NRP-synthases
Gene Modules
aps1
Module ?
Specificity: pipecolic acid / proline
Evidence for specificity:
  • Structure-based inference
  • Knock-out studies
Module ?
Specificity: isoleucine
Evidence for specificity:
  • Structure-based inference
Module ?
Specificity: N1-methoxytryptophan
Evidence for specificity:
  • Structure-based inference
Module ?
Specificity: 2S-amino-8-oxodecanoic acid / 2S-aminodecanoic acid / 2S-amino-8S-hydroxydecanoic acid
Evidence for specificity:
  • Structure-based inference
  • Knock-out studies
Annotation changelog
MIBiG version Submitter Notes
1.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Submitted
2.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Migrated from v1.4
  • Updated compound(s) information (NPAtlas curation)
3.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Added NRP substrate specificities
Detailed domain annotation
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Similar known gene clusters
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