BGC0000304: apicidin biosynthetic gene cluster from Fusarium incarnatum
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Location: 1 - 63,164 nt. (total: 63,164 nt).
This entry is originally from NCBI GenBank GQ331953.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
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Gene details
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General
Compounds
Genes
Biosynthesis
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0000304
Short description apicidin biosynthetic gene cluster from Fusarium incarnatum
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: unknown
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRPS (Type I)
Loci
GQ331953.1
via
Compounds
  • apicidin
Species Fusarium incarnatum [taxonomy]
References
Chemical products information
apicidin Evidence:
Copy SMILES
C34H49N5O6
Chemical database entries
NPAtlas
PubCHEM
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • ACZ66248.1
  • aps2
 9934 - 11129 (+) APS2
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    • ACZ66249.1
    • aps3
    		 11170 - 12153 (-) APS3
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      • ACZ66250.1
      • aps4
      		 12703 - 14066 (-) APS4
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        • ACZ66251.1
        • aps5
        		 14493 - 19523 (+) APS5
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          • ACZ66252.1
          • aps6
          		 23702 - 24928 (+) APS6
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            • ACZ66253.1
            • aps7
            		 25175 - 26995 (-) APS7
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              • ACZ66254.1
              • aps8
              		 27326 - 29141 (+) APS8
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                • ACZ66255.1
                • aps9
                		 29500 - 31442 (+) APS9
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                  • ACZ66256.1
                  • aps10
                  		 32219 - 32971 (-) APS10
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                    • ACZ66257.1
                    • aps11
                    		 33385 - 35362 (-) APS11
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                      • ACZ66258.1
                      • aps1
                      		 35951 - 51438 (+) APS1
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                        Biosynthesis information

                        Biosynthetic modules

                        Name
                        Unk01
                        Type
                        nrps-type1
                        Genes
                        aps1
                        Substrates
                        pipecolic acid, proline (evidence: Structure-based inference, Knock-out studies)
                        Integrated Monomers
                        Domains
                        adenylation
                        Name
                        Unk02
                        Type
                        nrps-type1
                        Genes
                        aps1
                        Substrates
                        isoleucine (evidence: Structure-based inference [1])
                        Integrated Monomers
                        Domains
                        adenylation
                        Name
                        Unk03
                        Type
                        nrps-type1
                        Genes
                        aps1
                        Substrates
                        N1-methoxytryptophan (evidence: Structure-based inference [1])
                        Integrated Monomers
                        Domains
                        adenylation
                        Name
                        Unk04
                        Type
                        nrps-type1
                        Genes
                        aps1
                        Substrates
                        2S-amino-8-oxodecanoic acid, 2S-aminodecanoic acid, 2S-amino-8S-hydroxydecanoic acid (evidence: Structure-based inference, Knock-out studies)
                        Integrated Monomers
                        Domains
                        adenylation
                        Annotation changelog

                        Entry version: next

                        Date
                        Changes
                        Submitters
                        Reviewers
                        2024-07-23
                        MIBiG v4 annotathon
                        • (ID: 4B6CAZ6GBFQV2DK75DYGLHB6)
                        • (ID: C62OJVVH7XOTOTFZSJT727YU)
                        • (ID: X3QVFXOIMTNXSB4JQGP4RI6A)
                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                        Entry version: 3

                        Date
                        Changes
                        Submitters
                        Reviewers
                        2022-09-15
                        Added NRP substrate specificities
                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                        Entry version: 2

                        Date
                        Changes
                        Submitters
                        Reviewers
                        2019-10-16
                        Migrated from v1.4
                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                        2019-10-16
                        Updated compound(s) information (NPAtlas curation)
                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                        Entry version: 1

                        Date
                        Changes
                        Submitters
                        Reviewers
                        2015-06-12
                        Submitted
                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                        Detailed domain annotation
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