BGC0000305: arthrofactin A biosynthetic gene cluster from Pseudomonas sp. MIS38
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Location: 1 - 40,430 nt. (total: 40,430 nt).
This entry is originally from NCBI GenBank AB107223.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
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Gene details
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General
Compounds
Genes
Biosynthesis
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0000305
Short description arthrofactin A biosynthetic gene cluster from Pseudomonas sp. MIS38
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: complete
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRPS (Type I)
Loci
AB107223.1
via Knock-out studies, Enzymatic assays
Compounds
  • arthrofactin A
Species Pseudomonas sp. MIS38 [taxonomy]
References
Chemical products information
arthrofactin A Evidence:
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C64H111N11O20
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • BAC67533.1
 359 - 1153 (-) putative DNA binding protein
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    • BAC67534.2
    • arfA
    		 1642 - 8055 (+) arthrofactin synthetase A
    • Scaffold biosynthesis
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    • BAC67535.1
    • arfB
    		 8237 - 21253 (+) arthrofactin synthetase B
    • Scaffold biosynthesis
    • Knock-out
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    • BAC67536.1
    • arfC
    		 21319 - 39093 (+) arthrofactin synthetase C
    • Scaffold biosynthesis
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    • BAC67537.1
    		 39220 - 40308 (+) putative periplasmic protein
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      • BAC67538.1
      		 40311 - >40430 (+) putative ABC transporter protein
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        Biosynthesis information

        Biosynthetic modules

        Name
        2
        Type
        nrps-type1
        Genes
        arfA
        Substrates
        aspartic acid (evidence: Structure-based inference)
        Integrated Monomers
        Domains
        condensation (Dual), adenylation, epimerase
        Name
        1
        Type
        nrps-type1
        Genes
        arfA
        Substrates
        leucine (evidence: Structure-based inference)
        Integrated Monomers
        Domains
        condensation (Starter), adenylation, epimerase
        Name
        3
        Type
        nrps-type1
        Genes
        arfB
        Substrates
        threonine (evidence: Structure-based inference)
        Integrated Monomers
        Domains
        condensation (Dual), adenylation, epimerase
        Name
        4
        Type
        nrps-type1
        Genes
        arfB
        Substrates
        leucine (evidence: Structure-based inference)
        Integrated Monomers
        Domains
        condensation (Dual), adenylation, epimerase
        Name
        5
        Type
        nrps-type1
        Genes
        arfB
        Substrates
        leucine (evidence: Structure-based inference)
        Integrated Monomers
        Domains
        condensation (Dual), adenylation, epimerase
        Name
        6
        Type
        nrps-type1
        Genes
        arfB
        Substrates
        serine (evidence: Structure-based inference)
        Integrated Monomers
        Domains
        condensation (Dual), adenylation, epimerase
        Name
        7
        Type
        nrps-type1
        Genes
        arfC
        Substrates
        leucine (evidence: Structure-based inference)
        Integrated Monomers
        Domains
        condensation (Dual), adenylation
        Name
        8
        Type
        nrps-type1
        Genes
        arfC
        Substrates
        serine (evidence: Structure-based inference)
        Integrated Monomers
        Domains
        condensation (LCL), adenylation, epimerase
        Name
        9
        Type
        nrps-type1
        Genes
        arfC
        Substrates
        isoleucine (evidence: Structure-based inference)
        Integrated Monomers
        Domains
        condensation (Dual), adenylation
        Name
        10
        Type
        nrps-type1
        Genes
        arfC
        Substrates
        isoleucine (evidence: Structure-based inference)
        Integrated Monomers
        Domains
        condensation (LCL), adenylation
        Name
        11
        Type
        nrps-type1
        Genes
        arfC
        Substrates
        aspartic acid (evidence: Structure-based inference)
        Integrated Monomers
        Domains
        condensation (LCL), adenylation
        Annotation changelog

        Entry version: 4

        Date
        Changes
        Submitters
        Reviewers
        2022-10-07
        Update chemical activity to schema version 2.11
        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

        Entry version: 3

        Date
        Changes
        Submitters
        Reviewers
        2022-09-15
        Corrected NRP module activity
        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
        2022-09-15
        Updated NRP substrate specificities
        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

        Entry version: 2

        Date
        Changes
        Submitters
        Reviewers
        2019-10-16
        Migrated from v1.4
        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

        Entry version: 1

        Date
        Changes
        Submitters
        Reviewers
        2015-06-12
        Submitted
        • (ID: KRKW7VUNYGF36O3Z7FAQ6YXG)
        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
        Detailed domain annotation
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