BGC0000306 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0000306 (Streptomyces filamentosus NRRL 11379)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	NRPS	1	30,611	arylomycin	NRPS:Type I	100%

BGC0000306 - Region 1 - NRPS

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Location: 1 - 30,611 nt. (total: 30,611 nt) Show pHMM detection rules used

Region on contig edge.

NRPS: cds(Condensation and (AMP-binding or A-OX))

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

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Gene details

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Gene overview

MIBiG

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 30,612
Label		BGC0000306

Detailed domain annotation

Selected features only

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Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000306	1.00	NRP	arylomycin	Streptomyces filamentosus NRRL 11379
BGC0000313	0.33	NRP	beauvericin	Beauveria bassiana
BGC0002075	0.32	NRP, Alkaloid	pyreudione A, pyreudione B, pyreudione C, pyreudione D, pyreudione E	Pseudomonas fluorescens
BGC0000342	0.32	NRP	enniatin	Fusarium equiseti
BGC0002631	0.32	RiPP	myxarylin	Pyxidicoccus fallax
BGC0000417	0.32	NRP	rhodochelin	Rhodococcus jostii RHA1
BGC0000375	0.32	NRP	indigoidine	Streptomyces chromofuscus
BGC0002157	0.32	NRP, Alkaloid	(-)-ditryptophenaline	Aspergillus flavus
BGC0000901	0.31	Other	ferrichrome	Aspergillus niger
BGC0001132	0.31	NRP	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000306	1.00	NRP	arylomycin	Streptomyces filamentosus NRRL 11379
BGC0000313	0.66	NRP	beauvericin	Beauveria bassiana
BGC0002075	0.66	NRP, Alkaloid	pyreudione A, pyreudione B, pyreudione C, pyreudione D, pyreudione E	Pseudomonas fluorescens
BGC0000342	0.66	NRP	enniatin	Fusarium equiseti
BGC0002631	0.65	RiPP	myxarylin	Pyxidicoccus fallax
BGC0000417	0.65	NRP	rhodochelin	Rhodococcus jostii RHA1
BGC0000375	0.65	NRP	indigoidine	Streptomyces chromofuscus
BGC0002157	0.65	NRP, Alkaloid	(-)-ditryptophenaline	Aspergillus flavus
BGC0000901	0.65	Other	ferrichrome	Aspergillus niger
BGC0001132	0.64	NRP	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061

Similar known gene clusters from MIBiG 4.0

Module view

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NRPS/PKS products

NRPS/PKS substrates

Predicted core structure(s)

For candidate cluster 1, location 0 - 30611:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (D-NMe-Ser - D-Ala) + (Gly - NMe-Hpg - Ala - Tyr)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

SSIG_07966

Search NORINE for peptide: strict or relaxed

AMP-binding (463..870): Ser

nrpys: Ser

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Aliphatic chain or phenyl group with -OH (Ser, Thr, Dhpg, Hpg)
Small clusters prediction:: ser (Ser)
Single AA prediction:: ser (Ser)

Stachelhaus prediction details:

Stachelhaus sequence:: DVWHMSLIDK
Nearest Stachelhaus code(s):: Ser DVWHMSLIDK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

AMP-binding (2409..2806): Ala

nrpys: Ala

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
Small clusters prediction:: Tiny, hydrophilic, transition to aliphatic (Gly, Ala)
Single AA prediction:: ala (Ala)

Stachelhaus prediction details:

Stachelhaus sequence:: DVFSVALVYK
Nearest Stachelhaus code(s):: Ala DVFSVALVYK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

SSIG_05823

Search NORINE for peptide: strict or relaxed

AMP-binding (11..270): Gly

nrpys: Gly

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
Small clusters prediction:: Tiny, hydrophilic, transition to aliphatic (Gly, Ala)
Single AA prediction:: gly (Gly)

Stachelhaus prediction details:

Stachelhaus sequence:: DILQLGVIWK
Nearest Stachelhaus code(s):: Gly DILQLGVIWK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

AMP-binding (952..1344): Hpg

nrpys: Hpg

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Aliphatic chain or phenyl group with -OH (Ser, Thr, Dhpg, Hpg)
Small clusters prediction:: Polar, uncharged (hydroxy-phenyl) (Dhpg, Hpg)
Single AA prediction:: hpg (Hpg)

Stachelhaus prediction details:

Stachelhaus sequence:: DIYHLGLLCK
Nearest Stachelhaus code(s):: Hpg DIYHLGLLCK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

AMP-binding (2411..2806): Ala

nrpys: Ala

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
Small clusters prediction:: Tiny, hydrophilic, transition to aliphatic (Gly, Ala)
Single AA prediction:: ala (Ala)

Stachelhaus prediction details:

Stachelhaus sequence:: DVFSVALVYK
Nearest Stachelhaus code(s):: Ala DVFSVALVYK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

AMP-binding (3464..3865): Tyr

nrpys: Tyr

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aromatic (Phe, Tyr, diOH-Bz, Ph-Gly, bOH-Tyr)
Large clusters prediction:: Aromatic side chain (Phe, Trp, Ph-Gly, Tyr, bOH-Tyr)
Small clusters prediction:: Polar aromatic ring (Tyr, bOH-Tyr)
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DASTVAAVCK
Nearest Stachelhaus code(s):: Tyr DASTVAAVCK (100% 8Å match)
Stachelhaus code match:: 100% (strong)