BGC0000306 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0000306 (Streptomyces filamentosus NRRL 11379)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	NRPS	1	30,611	salinamide A / salinamide B / salinamide C / salinamide D / salinamide E / salinamide F / desmethylsalinamide C / desmethylsalinamide E	NRP:Cyclic depsipeptide + Polyketide:Modular type I	35%

BGC0000306 - Region 1 - NRPS

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Location: 1 - 30,611 nt. (total: 30,611 nt) Show pHMM detection rules used

Region on contig edge.

NRPS: cds(Condensation and (AMP-binding or A-OX))

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

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Gene details

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MIBiG

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

External annotation

Name		MIBiG
Version		3.0

Type		Subregion
Location		1 - 30,612
Label		BGC0000306

Detailed domain annotation

Selected features only

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Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000306.1	0.83	NRP	arylomycin	Streptomyces filamentosus NRRL 11379
BGC0001185.1	0.33	NRP	bacillibactin	Bacillus velezensis FZB42
BGC0001878.1	0.33	NRP, Polyketide	detoxin N2, detoxin N3	Streptomyces sp. NRRL B-1347
BGC0001841.1	0.32	NRP, Polyketide	detoxin P1, detoxin P2, detoxin P3	Amycolatopsis jejuensis
BGC0002075.1	0.32	NRP, Alkaloid	Pyreudione A, Pyreudione B, Pyreudione C, Pyreudione D, Pyreudione E	Pseudomonas fluorescens
BGC0000417.1	0.32	NRP	rhodochelin	Rhodococcus jostii RHA1
BGC0000348.1	0.30	NRP	ergovaline	Epichloe festucae var. lolii
BGC0000401.1	0.30	NRP	paenibactin	Paenibacillus elgii B69
BGC0001132.1	0.30	NRP	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0001149.1	0.28	NRP, Saccharide	brabantamide A	Pseudomonas sp. SHC52

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000306.1	0.94	NRP	arylomycin	Streptomyces filamentosus NRRL 11379
BGC0001185.1	0.67	NRP	bacillibactin	Bacillus velezensis FZB42
BGC0001878.1	0.66	NRP, Polyketide	detoxin N2, detoxin N3	Streptomyces sp. NRRL B-1347
BGC0001841.1	0.66	NRP, Polyketide	detoxin P1, detoxin P2, detoxin P3	Amycolatopsis jejuensis
BGC0002075.1	0.66	NRP, Alkaloid	Pyreudione A, Pyreudione B, Pyreudione C, Pyreudione D, Pyreudione E	Pseudomonas fluorescens
BGC0000417.1	0.66	NRP	rhodochelin	Rhodococcus jostii RHA1
BGC0000348.1	0.64	NRP	ergovaline	Epichloe festucae var. lolii
BGC0000401.1	0.64	NRP	paenibactin	Paenibacillus elgii B69
BGC0001132.1	0.63	NRP	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0001149.1	0.62	NRP, Saccharide	brabantamide A	Pseudomonas sp. SHC52

Similar known gene clusters

Module view

Legend

NRPS/PKS products

NRPS/PKS monomers

Predicted core structure(s)

For candidate cluster 1, location 0 - 30611:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (D-NMe-ser - D-ala) + (gly - NMe-hpg - ala - tyr)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS monomer predictions

SSIG_07966

Search NORINE for peptide: strict or relaxed

AMP-binding (463..870): ser

NRPSPredictor2: ser

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic
Large clusters prediction:: ser, thr, dhpg, hpg
Small clusters prediction:: ser
Single AA prediction:: ser

Stachelhaus prediction details:

Stachelhaus sequence:: DVWHMSLIDK
Nearest Stachelhaus code:: ser
Stachelhaus code match:: 100% (strong)

AMP-binding (2409..2806): ala

NRPSPredictor2: ala

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic
Large clusters prediction:: gly, ala, val, leu, ile, abu, iva
Small clusters prediction:: gly, ala
Single AA prediction:: ala

Stachelhaus prediction details:

Stachelhaus sequence:: DVFSVaLVyK
Nearest Stachelhaus code:: d-lyserg
Stachelhaus code match:: 80% (moderate)

SSIG_05823

Search NORINE for peptide: strict or relaxed

AMP-binding (11..270): gly

NRPSPredictor2: gly

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic
Large clusters prediction:: gly, ala, val, leu, ile, abu, iva
Small clusters prediction:: gly, ala
Single AA prediction:: gly

Stachelhaus prediction details:

Stachelhaus sequence:: DILQLGVIWK
Nearest Stachelhaus code:: gly
Stachelhaus code match:: 100% (strong)

AMP-binding (952..1344): hpg

NRPSPredictor2: hpg

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic
Large clusters prediction:: ser, thr, dhpg, hpg
Small clusters prediction:: dhpg, hpg
Single AA prediction:: hpg

Stachelhaus prediction details:

Stachelhaus sequence:: DiYHLGLLCK
Nearest Stachelhaus code:: hpg
Stachelhaus code match:: 90% (moderate)

AMP-binding (2411..2806): ala

NRPSPredictor2: ala

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic
Large clusters prediction:: gly, ala, val, leu, ile, abu, iva
Small clusters prediction:: gly, ala
Single AA prediction:: ala

Stachelhaus prediction details:

Stachelhaus sequence:: DVFSVaLVyK
Nearest Stachelhaus code:: d-lyserg
Stachelhaus code match:: 80% (moderate)

AMP-binding (3464..3865): tyr

NRPSPredictor2: tyr

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aromatic
Large clusters prediction:: phe, trp, phg, tyr, bht
Small clusters prediction:: tyr, bht
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DASTVAAVCK
Nearest Stachelhaus code:: tyr
Stachelhaus code match:: 100% (strong)