Genomic loci for this biosynthetic pathway

Cluster Type From To
The following clusters are from record BGC0000306.1:
Cluster 1NRP130611

BGC0000306, arylomycin biosynthetic gene cluster from Streptomyces roseosporus. Locus 1. Full MIBiG entry.

Chemical compounds

Compound: Arylomycin
PubChem ID: 54586211
SMILES string: Copy to clipboard
Molecular formula: C46H68N6O11
Average molecular mass: 881.081 Da
Molecular activity: Antibacterial
Molecular target: typeI signal peptidases

Class-specific details

Biosynthetic class(es):
NRP
Nonribosomal peptide subclass:
Other lipopeptide (linear)
10-methylundecanoic acid
Thioesterase type:
Unknown
Release / cyclization type:
Hydrolysis

Nonribosomal peptide synthetases:
No gene ID (EWS95122.1)
Module 1
A specificity: Serine
Evidence for specificity: Structure-based inference
AA is epimerized
C domain subtype: Starter
Scaffold-modifying domain: Methylation
Module 2
A specificity: Alanine
Evidence for specificity: Structure-based inference
AA is epimerized
C domain subtype: Other
No gene ID (EWS95124.1)
Module 2
A specificity: Glycine
Evidence for specificity: Structure-based inference
C domain subtype: N/A
Module 3
A specificity: 4-Hydroxyphenylglycine
Evidence for specificity: Structure-based inference
C domain subtype: LCL
Scaffold-modifying domain: Methylation
Module 4
A specificity: Alanine
Evidence for specificity: Structure-based inference
C domain subtype: LCL
Module 5
A specificity: Tyrosine
Evidence for specificity: Structure-based inference
C domain subtype: LCL

Gene cluster description

arylomycin (BGC0000306). Gene Cluster 1. Biosynthetic class = NRP. GenBank ABYX02000001, positions 6273710-6304320. Click on genes for more information.

Legend:

biosynthetic genes
transport-related genes
regulatory genes
other genes

Domain annotation

Homologous known gene clusters

General MIBiG information on this cluster

Complete gene cluster sequence?complete
Evidence for cluster-compound connection:Sequence-based prediction
MIxS-compliance:Unknown
Contact for this cluster:Neha Garg (University of California at San Diego)

Literature references

1. Liu WT et al. (2011) Imaging mass spectrometry and genome mining via short sequence tagging identified the anti-infective agent arylomycin in Streptomyces roseosporus. J Am Chem Soc 133(45):18010-3. doi: 10.1021/ja2040877. Epub 2011 Oct