BGC0000306: arylomycin biosynthetic gene cluster from Streptomyces filamentosus NRRL 11379
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Location: 6,273,710 - 6,304,320 nt. (total: 30,611 nt).
This entry is originally from NCBI GenBank ABYX02000001.1.

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core biosynthetic genes
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Gene details
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General
Compounds
Genes
NRP
History
KnownClusterBlast
NRPS/PKS domains
General information about the BGC
MIBiG accession BGC0000306
Short description arylomycin biosynthetic gene cluster from Streptomyces filamentosus NRRL 11379
Status Minimal annotation: no
A minimal annotation only contains information on the BGC loci and one or more linked chemical product(s)

Completeness: complete
Whether the loci encodes everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRP (Other lipopeptide)
Loci NCBI GenBank: ABYX02000001.1
Compounds
  • arylomycin
Species Streptomyces filamentosus NRRL 11379 [taxonomy]
References
Chemical products information
arylomycin
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C46H68N6O11
Chemical database entries
PubCHEM
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • SSIG_07966
  • EWS95122.1
6273710 - 6284167 (-) hypothetical protein
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  • SSIG_05822
  • EWS95123.1
6284796 - 6285965 (+) hypothetical protein
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  • SSIG_05823
  • EWS95124.1
6286024 - 6298917 (+) hypothetical protein
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  • SSIG_05824
  • EWS95125.1
6298943 - 6299164 (+) MbtH domain-containing protein
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  • SSIG_05825
  • EWS95126.1
6299212 - 6300276 (+) 4-hydroxyphenylpyruvate dioxygenase
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  • SSIG_05826
  • EWS95127.1
6300273 - 6301388 (+) L-lactate oxidase
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  • SSIG_05827
  • EWS95128.1
6301381 - 6302730 (+) GntR family transcriptional regulator
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  • SSIG_05828
  • EWS95129.1
6302792 - 6303664 (+) heme ABC exporter, ATP-binding protein CcmA
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  • SSIG_05829
  • EWS95130.1
6303697 - 6304320 (+) hypothetical protein
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NRP-specific information
Subclass Other lipopeptide
Cyclic? no
Release type
  • Hydrolysis
Lipid moiety 10-methylundecanoic acid
Thioesterase genes
  • SSIG_05823 (Unknown)
NRP-synthases
Gene Modules
EWS95122.1
Module 1
Specificity: Serine
Evidence for specificity:
  • Structure-based inference
Condensation domain type: Starter
Modification domains: Methylation
Module 2
Specificity: Alanine
Evidence for specificity:
  • Structure-based inference
Condensation domain type: Unknown
EWS95124.1
Module 2
Specificity: Glycine
Evidence for specificity:
  • Structure-based inference
Module 3
Specificity: 4-Hydroxyphenylglycine
Evidence for specificity:
  • Structure-based inference
Condensation domain type: LCL
Modification domains: Methylation
Module 4
Specificity: Alanine
Evidence for specificity:
  • Structure-based inference
Condensation domain type: LCL
Module 5
Specificity: Tyrosine
Evidence for specificity:
  • Structure-based inference
Condensation domain type: LCL
Annotation changelog
MIBiG version Submitter Notes
1.0
  • Hidden contributor (ID: UK5BZZ5BLXFR5LGS2GITT5IB, no GDPR consent given).
  • Submitted
2.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Migrated from v1.4
Similar known gene clusters
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Detailed domain annotation
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