BGC0000308 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0000308 (Staphylococcus aureus subsp. aureus str. JKD6008)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	NRPS	1	7,851	aureusimine A/aureusimine B/aureusimine C	NRPS:Type I	100%

BGC0000308 - Region 1 - NRPS

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Location: 1 - 7,851 nt. (total: 7,851 nt) Show pHMM detection rules used

Region on contig edge.

NRPS: cds(Condensation and (AMP-binding or A-OX))

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

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Gene details

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Gene overview

MIBiG

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 7,852
Label		BGC0000308

Detailed domain annotation

Selected features only

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Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000308	1.00	NRP	aureusimine A, aureusimine B, aureusimine C	Staphylococcus aureus subsp. aureus str. JKD6008
BGC0001132	0.23	NRP	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0001135	0.23	NRP	bicornutin A1, bicornutin A2	Xenorhabdus budapestensis
BGC0001128	0.23	NRP	gamexpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0002286	0.23	NRP	ririwpeptide A, ririwpeptide B, ririwpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001641	0.22	NRP	kolossin	Photorhabdus laumondii subsp. laumondii TTO1
BGC0000307	0.22	NRP	AbT1	Aureobasidium pullulans
BGC0002437	0.22	NRP	thermoactinoamide A	Thermoactinomyces sp. AS95
BGC0001240	0.21	NRP	serinocyclin A, serinocyclin B	Metarhizium robertsii
BGC0001561	0.21	NRP	curacomycin	Streptomyces curacoi

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000308	1.00	NRP	aureusimine A, aureusimine B, aureusimine C	Staphylococcus aureus subsp. aureus str. JKD6008
BGC0001132	0.57	NRP	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0001135	0.56	NRP	bicornutin A1, bicornutin A2	Xenorhabdus budapestensis
BGC0001128	0.56	NRP	gamexpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0002286	0.56	NRP	ririwpeptide A, ririwpeptide B, ririwpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001641	0.55	NRP	kolossin	Photorhabdus laumondii subsp. laumondii TTO1
BGC0000307	0.55	NRP	AbT1	Aureobasidium pullulans
BGC0002437	0.55	NRP	thermoactinoamide A	Thermoactinomyces sp. AS95
BGC0001240	0.54	NRP	serinocyclin A, serinocyclin B	Metarhizium robertsii
BGC0001561	0.54	NRP	curacomycin	Streptomyces curacoi

Similar known gene clusters from MIBiG 4.0

Module view

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NRPS/PKS products

NRPS/PKS substrates

Predicted core structure(s)

For candidate cluster 1, location 0 - 7851:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (Val - Tyr)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

SAA6008_00157

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AMP-binding (423..813): Val

nrpys: Val

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
Small clusters prediction:: Aliphatic, branched hydrophobic (Val, Leu, Ile, Abu, Ival)
Single AA prediction:: val (Val)

Stachelhaus prediction details:

Stachelhaus sequence:: DAFWLGGTFK
Nearest Stachelhaus code(s):: Val DAFWLGGTFK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

AMP-binding (1448..1840): Tyr

nrpys: Tyr

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: N/A
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DAMSIGAVIK
Nearest Stachelhaus code(s):: Tyr DAMSIGAVIK (100% 8Å match)
Stachelhaus code match:: 100% (strong)