BGC0000309: bacillibactin biosynthetic gene cluster from Bacillus subtilis subsp. subtilis str. 168
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Location: 3,280,293 - 3,293,359 nt. (total: 13,067 nt).
This entry is originally from NCBI GenBank AL009126.3.

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core biosynthetic genes
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General
Compounds
Genes
Biosynthesis
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0000309
Short description bacillibactin biosynthetic gene cluster from Bacillus subtilis subsp. subtilis str. 168
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: unknown
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRPS (Type I)
Loci
AL009126.3
3280293 - 3293359
via
Compounds
  • bacillibactin
Species Bacillus subtilis subsp. subtilis str. 168 [taxonomy]
References
Chemical products information
bacillibactin Evidence:
Copy SMILES
C39H42N6O18
Chemical database entries
PubCHEM
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • BSU_31959
  • CAX52685.1
  • mbtH
 3280294 - 3280503 (-) stimulator of DhbF tyrosine adenylation activity
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    • BSU_31960
    • CAB15186.3
    • dhbF
    		 3280519 - 3287655 (-) siderophore 2,3-dihydroxybenzoate-glycine-threonine trimeric ester bacillibactin synthetase
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      • BSU_31970
      • CAB15187.1
      • dhbB
      		 3287675 - 3288613 (-) isochorismatase (siderophore specific)
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        • BSU_31980
        • CAB15188.1
        • dhbE
        		 3288641 - 3290260 (-) 2,3-dihydroxybenzoate-AMP ligase
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          • BSU_31990
          • CAB15189.2
          • dhbC
          		 3290289 - 3291485 (-) isochorismate synthase (siderophore-specific)
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            • BSU_32000
            • CAB15190.2
            • dhbA
            		 3291511 - 3292296 (-) 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase
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              • BSU_32010
              • CAB15191.2
              • besA
              		 3292490 - 3293359 (-) bacillibactin trilactone hydrolase
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                Biosynthesis information

                Biosynthetic modules

                Name
                Unk01
                Type
                nrps-type1
                Genes
                dhbF
                Substrates
                glycine (evidence: Mass spectrometry [1])
                Integrated Monomers
                Domains
                adenylation
                Name
                Unk02
                Type
                nrps-type1
                Genes
                dhbF
                Substrates
                threonine (evidence: Mass spectrometry [1])
                Integrated Monomers
                Domains
                adenylation
                Name
                Unk03
                Type
                nrps-type1
                Genes
                dhbE
                Substrates
                2,3-dihydroxybenzoic acid (evidence: Mass spectrometry [1])
                Integrated Monomers
                Domains
                adenylation
                Annotation changelog

                Entry version: 4

                Date
                Changes
                Submitters
                Reviewers
                2022-10-07
                Update chemical activity to schema version 2.11
                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                Entry version: 3

                Date
                Changes
                Submitters
                Reviewers
                2022-09-15
                Refined reference coordinates
                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                2022-09-15
                Updated bioactivity data
                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                2022-09-15
                Added NRP substrate specificities
                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                Entry version: 2

                Date
                Changes
                Submitters
                Reviewers
                2019-10-16
                Migrated from v1.4
                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                Entry version: 1

                Date
                Changes
                Submitters
                Reviewers
                2015-06-12
                Submitted
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                Detailed domain annotation
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