BGC0000309: bacillibactin biosynthetic gene cluster from Bacillus subtilis subsp. subtilis str. 168
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Location: 3,280,293 - 3,293,359 nt. (total: 13,067 nt).
This entry is originally from NCBI GenBank AL009126.3.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
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Gene details
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General
Compounds
Genes
NRP
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0000309
Short description bacillibactin biosynthetic gene cluster from Bacillus subtilis subsp. subtilis str. 168
Status Minimal annotation: no
A minimal annotation only contains information on the BGC loci and one or more linked chemical product(s)

Completeness: Unknown
Whether the loci encodes everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRP
Loci NCBI GenBank: AL009126.3
Compounds
  • bacillibactin
Species Bacillus subtilis subsp. subtilis str. 168 [taxonomy]
References
Chemical products information
bacillibactin
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C39H42N6O18
Chemical database entries
PubCHEM
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • BSU_31959
  • CAX52685.1
  • mbtH
 3280294 - 3280503 (-) stimulator of DhbF tyrosine adenylation activity
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  • BSU_31960
  • CAB15186.3
  • dhbF
 3280519 - 3287655 (-) siderophore 2,3-dihydroxybenzoate-glycine-threonine trimeric ester bacillibactin synthetase
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  • BSU_31970
  • CAB15187.1
  • dhbB
 3287675 - 3288613 (-) isochorismatase (siderophore specific)
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  • BSU_31980
  • CAB15188.1
  • dhbE
 3288641 - 3290260 (-) 2,3-dihydroxybenzoate-AMP ligase
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  • BSU_31990
  • CAB15189.2
  • dhbC
 3290289 - 3291485 (-) isochorismate synthase (siderophore-specific)
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  • BSU_32000
  • CAB15190.2
  • dhbA
 3291511 - 3292296 (-) 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase
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  • BSU_32010
  • CAB15191.2
  • besA
 3292490 - 3293359 (-) bacillibactin trilactone hydrolase
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NRP-specific information
Subclass N/A
Cyclic? no
NRP-synthases
Gene Modules
dhbF
Module ?
Specificity: glycine
Evidence for specificity:
  • Mass spectrometry
Module ?
Specificity: threonine
Evidence for specificity:
  • Mass spectrometry
dhbE
Module ?
Specificity: 2,3-dihydroxybenzoic acid
Evidence for specificity:
  • Mass spectrometry
Annotation changelog
MIBiG version Submitter Notes
1.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Submitted
2.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Migrated from v1.4
3.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Refined reference coordinates
  • Updated bioactivity data
  • Added NRP substrate specificities
3.1
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Update chemical activity to schema version 2.11
Detailed domain annotation
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