BGC0000310: bacitracin biosynthetic gene cluster from Bacillus licheniformis
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Location: 1 - 48,774 nt. (total: 48,774 nt).
This entry is originally from NCBI GenBank AF007865.2.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
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Gene details
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General
Compounds
Genes
Biosynthesis
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0000310
Short description bacitracin biosynthetic gene cluster from Bacillus licheniformis
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: unknown
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRPS (Type I)
Loci
AF007865.2
via
Compounds
  • bacitracin
Species Bacillus licheniformis [taxonomy]
References
Chemical products information
bacitracin Evidence:
Copy SMILES
C66H103N17O16S1
Chemical database entries
PubCHEM
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • AAD21211.1
  • bacT
 411 - 1115 (+) BacT
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    • AAC06346.1
    • bacA
    		 1451 - 17218 (+) bacitracin synthetase 1
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      • AAC06347.1
      • bacB
      		 17330 - 25153 (+) bacitracin synthetase 2
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        • AAC06348.1
        • bacC
        		 25258 - 44337 (+) bacitracin synthetase 3
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          • AAD21216.2
          • bacR
          		 44497 - 45213 (+) BacR
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            • AAD21212.2
            • bacS
            		 45191 - 46237 (+) BacS
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              • AAD21213.1
              • bcrA
              		 46313 - 47233 (+) BcrA
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                • AAD21214.1
                • bcrB
                		 47334 - 47960 (+) BcrB
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                  • AAD21215.1
                  • bcrC
                  		 48081 - 48692 (+) BcrC
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                    Biosynthesis information

                    Biosynthetic modules

                    Name
                    Unk01
                    Type
                    nrps-type1
                    Genes
                    bacA
                    Substrates
                    isoleucine (evidence: )
                    Integrated Monomers
                    Domains
                    adenylation
                    Name
                    Unk02
                    Type
                    nrps-type1
                    Genes
                    bacA
                    Substrates
                    cysteine (evidence: )
                    Integrated Monomers
                    Domains
                    adenylation
                    Name
                    Unk03
                    Type
                    nrps-type1
                    Genes
                    bacA
                    Substrates
                    leucine (evidence: )
                    Integrated Monomers
                    Domains
                    adenylation
                    Name
                    Unk04
                    Type
                    nrps-type1
                    Genes
                    bacA
                    Substrates
                    glutamic acid (evidence: )
                    Integrated Monomers
                    Domains
                    adenylation
                    Name
                    Unk05
                    Type
                    nrps-type1
                    Genes
                    bacA
                    Substrates
                    isoleucine (evidence: )
                    Integrated Monomers
                    Domains
                    adenylation
                    Name
                    Unk06
                    Type
                    nrps-type1
                    Genes
                    bacB
                    Substrates
                    lysine (evidence: Structure-based inference [1], [2])
                    Integrated Monomers
                    Domains
                    adenylation
                    Name
                    Unk07
                    Type
                    nrps-type1
                    Genes
                    bacB
                    Substrates
                    ornithine (evidence: )
                    Integrated Monomers
                    Domains
                    adenylation
                    Name
                    Unk08
                    Type
                    nrps-type1
                    Genes
                    bacC
                    Substrates
                    isoleucine (evidence: )
                    Integrated Monomers
                    Domains
                    adenylation
                    Name
                    Unk09
                    Type
                    nrps-type1
                    Genes
                    bacC
                    Substrates
                    phenylalanine (evidence: Structure-based inference [1], [2])
                    Integrated Monomers
                    Domains
                    adenylation
                    Name
                    Unk10
                    Type
                    nrps-type1
                    Genes
                    bacC
                    Substrates
                    histidine (evidence: Structure-based inference [1], [2])
                    Integrated Monomers
                    Domains
                    adenylation
                    Name
                    Unk11
                    Type
                    nrps-type1
                    Genes
                    bacC
                    Substrates
                    aspartic acid (evidence: )
                    Integrated Monomers
                    Domains
                    adenylation
                    Name
                    Unk12
                    Type
                    nrps-type1
                    Genes
                    bacC
                    Substrates
                    asparagine (evidence: )
                    Integrated Monomers
                    Domains
                    adenylation
                    Annotation changelog

                    Entry version: 4

                    Date
                    Changes
                    Submitters
                    Reviewers
                    2022-10-07
                    Update chemical activity to schema version 2.11
                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                    Entry version: 3

                    Date
                    Changes
                    Submitters
                    Reviewers
                    2022-09-15
                    Updated bioactivity data
                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                    2022-09-15
                    Added NRP substrate specificities
                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                    Entry version: 2

                    Date
                    Changes
                    Submitters
                    Reviewers
                    2019-10-16
                    Migrated from v1.4
                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                    Entry version: 1

                    Date
                    Changes
                    Submitters
                    Reviewers
                    2015-06-12
                    Submitted
                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                    Detailed domain annotation
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