BGC0000311: balhimycin biosynthetic gene cluster from Amycolatopsis balhimycina DSM 5908
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Location: 1 - 66,669 nt. (total: 66,669 nt).
This entry is originally from NCBI GenBank Y16952.3.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
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General
Compounds
Genes
Biosynthesis
History
KnownClusterBlast
NRPS/PKS domains
General information about the BGC
MIBiG accession BGC0000311
Short description balhimycin biosynthetic gene cluster from Amycolatopsis balhimycina DSM 5908
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: complete
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • saccharide (None)
  • NRPS (Type I)
Loci
Y16952.3
1 - 66669
via Knock-out studies
Compounds
  • balhimycin
Species Amycolatopsis balhimycina DSM 5908 [taxonomy]
References
Chemical products information
balhimycin Evidence:
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C66H73Cl2N9O24
Chemical database entries
PubCHEM
NPAtlas
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • CAG25751.1
  • vanS
 <1 - 759 (-) putative two-component system sensor kinase
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    • CAG25752.1
    • vanR
    		 770 - 1447 (-) putative two-component system response regulator
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      • CAG25753.1
      • vanY
      		 1537 - 2157 (+) putative VanY-type carboxypeptidase
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        • CAG25754.1
        • bbr
        		 3011 - 3976 (+) StrR family transcriptional regulator
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          • CAG25755.1
          • pdh
          		 4106 - 4981 (+) putative prephenate dehydrogenase
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            • CAG25756.1
            • abc
            		 5180 - 7135 (+) putative ABC transporter ATP-binding protein
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              • CAC48360.1
              • bpsA
              		 7138 - 16635 (+) peptide synthetase
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                • CAC48361.1
                • bpsB
                		 16635 - 28868 (+) peptide synthetase
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                  • CAC48362.1
                  • bpsC
                  		 28888 - 34464 (+) peptide synthetase
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                    • CAC48363.1
                    		 34461 - 34670 (+) hypothetical protein
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                      • CAA76547.1
                      • oxyA
                      		 34782 - 35957 (+) Cyclase
                      • Cyclization
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                      • CAA76548.1
                      • oxyB
                      		 36007 - 37203 (+) Cyclase
                      • Cyclization
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                      • CAA76549.1
                      • oxyC
                      		 37353 - 38573 (+) Cyclase
                      • Cyclization
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                      • CAA76550.1
                      • bhaA
                      		 38634 - 40109 (+) Halogenase
                      • Halogenation
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                      • CAA76551.1
                      • bgtfA
                      		 40192 - 41382 (+) glycosyltransferase
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                        • CAA76552.1
                        • bgtfB
                        		 41447 - 42676 (+) glycosyltransferase
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                          • CAA76553.1
                          • bgtfC
                          		 42824 - 44053 (+) glycosyltransferase
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                            • CAC48364.1
                            • dvaC
                            		 44087 - 45313 (+) putative C-3 methyl transferase
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                              • CAC48365.1
                              		 45409 - 46233 (+) hypothetical protein
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                                • CAC48366.1
                                • bmt
                                		 46265 - 47119 (+) putative N-methyl transferase
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                                  • CAC48367.1
                                  • pgat
                                  		 47100 - 48404 (-) phenylglycine amino transferase
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                                    • CAC48368.1
                                    • bhp
                                    		 48610 - 49464 (+) putative hydrolase
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                                      • CAC48369.1
                                      • bpsD
                                      		 49530 - 51275 (+) peptide synthetase
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                                        • CAC48370.1
                                        • oxyD
                                        		 51289 - 52479 (+) putative P450 monooxygenase
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                                          • CAC48371.1
                                          • hmaS
                                          		 52645 - 53715 (+) putative hydroxyphenyl pyruvate dioxygenase
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                                            • CAC48372.1
                                            • hmo
                                            		 53712 - 54788 (+) putative phenylglycolate oxidase
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                                              • CAC48373.1
                                              		 54879 - 56237 (+) putative antiporter
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                                                • CAC48374.1
                                                • dvaA
                                                		 56501 - 57913 (+) putative NDP-hexose 2,3-dehydratase
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                                                  • CAC48375.1
                                                  • dvaE
                                                  		 57915 - 58214 (+) putative 4-ketoreductase
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                                                    • CAC48376.1
                                                    • dvaB
                                                    		 58211 - 59320 (+) putative C-3 amino transferase
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                                                      • CAC48377.1
                                                      • dvaD
                                                      		 59344 - 59961 (+) putative 3,5 epimerase
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                                                        • CAC48378.1
                                                        • dpgA
                                                        		 60179 - 61297 (+) dihydroxyphenylacetic acid synthase
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                                                          • CAC48379.1
                                                          • dpgB
                                                          		 61294 - 61947 (+) putative enoyl-CoA hydratase
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                                                            • CAC48380.1
                                                            • dpgC
                                                            		 61944 - 63248 (+) hydroxyacyl-dehydrogenase
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                                                              • CAC48381.1
                                                              • dpgD
                                                              		 63245 - 64054 (+) putative enoyl-CoA-isomerase
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                                                                • CAG25757.1
                                                                • ald
                                                                		 64162 - 65259 (+) putative alodlase
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                                                                  • CAG25758.1
                                                                  • pks
                                                                  		 65378 - >66669 (+) putative type I polyketide synthase
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                                                                    Biosynthesis information

                                                                    Biosynthetic modules

                                                                    Name
                                                                    Unk01
                                                                    Type
                                                                    nrps-type1
                                                                    Genes
                                                                    bpsA
                                                                    Substrates
                                                                    leucine (evidence: )
                                                                    Integrated Monomers
                                                                    Domains
                                                                    adenylation
                                                                    Name
                                                                    Unk02
                                                                    Type
                                                                    nrps-type1
                                                                    Genes
                                                                    bpsA
                                                                    Substrates
                                                                    R-beta-hydroxytyrosine (evidence: Structure-based inference, Feeding study)
                                                                    Integrated Monomers
                                                                    Domains
                                                                    adenylation
                                                                    Name
                                                                    Unk03
                                                                    Type
                                                                    nrps-type1
                                                                    Genes
                                                                    bpsA
                                                                    Substrates
                                                                    asparagine (evidence: )
                                                                    Integrated Monomers
                                                                    Domains
                                                                    adenylation
                                                                    Name
                                                                    Unk04
                                                                    Type
                                                                    nrps-type1
                                                                    Genes
                                                                    bpsB
                                                                    Substrates
                                                                    4-hydroxyphenylglycine (evidence: ATP-PPi exchange assay [2], [6], [8])
                                                                    Integrated Monomers
                                                                    Domains
                                                                    adenylation
                                                                    Name
                                                                    Unk05
                                                                    Type
                                                                    nrps-type1
                                                                    Genes
                                                                    bpsB
                                                                    Substrates
                                                                    4-hydroxyphenylglycine (evidence: ATP-PPi exchange assay [2], [6], [8])
                                                                    Integrated Monomers
                                                                    Domains
                                                                    adenylation
                                                                    Name
                                                                    Unk06
                                                                    Type
                                                                    nrps-type1
                                                                    Genes
                                                                    bpsB
                                                                    Substrates
                                                                    R-beta-hydroxytyrosine (evidence: ATP-PPi exchange assay [6])
                                                                    Integrated Monomers
                                                                    Domains
                                                                    adenylation
                                                                    Name
                                                                    Unk07
                                                                    Type
                                                                    nrps-type1
                                                                    Genes
                                                                    bpsC
                                                                    Substrates
                                                                    3,5-dihydroxyphenylglycine (evidence: ATP-PPi exchange assay [6])
                                                                    Integrated Monomers
                                                                    Domains
                                                                    adenylation
                                                                    Name
                                                                    Unk08
                                                                    Type
                                                                    nrps-type1
                                                                    Genes
                                                                    bpsD
                                                                    Substrates
                                                                    tyrosine (evidence: Structure-based inference, Knock-out studies, Feeding study)
                                                                    Integrated Monomers
                                                                    Domains
                                                                    adenylation
                                                                    Annotation changelog

                                                                    Entry version: 6

                                                                    Date
                                                                    Changes
                                                                    Submitters
                                                                    Reviewers
                                                                    2024-06-07
                                                                    MIBiG v4 annotathon
                                                                    • (ID: 37IOAS4X5OHP34DPN55OLFBF)
                                                                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                                    Entry version: next

                                                                    Date
                                                                    Changes
                                                                    Submitters
                                                                    Reviewers
                                                                    2023-10-24
                                                                    Added 'Saccharide' as additional biosynthetic class. Specified BGC evidence according to 'pubmed:11932455'.
                                                                    • (ID: C62OJVVH7XOTOTFZSJT727YU)
                                                                    • (ID: 25OPJFS6AQU3ROUADEVDYF5E)

                                                                    Entry version: 4

                                                                    Date
                                                                    Changes
                                                                    Submitters
                                                                    Reviewers
                                                                    2022-10-07
                                                                    Update chemical activity to schema version 2.11
                                                                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                                    Entry version: 3

                                                                    Date
                                                                    Changes
                                                                    Submitters
                                                                    Reviewers
                                                                    2022-09-15
                                                                    Updated bioactivity data
                                                                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                    2022-09-15
                                                                    Added NRP substrate specificities
                                                                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                                    Entry version: 2

                                                                    Date
                                                                    Changes
                                                                    Submitters
                                                                    Reviewers
                                                                    2019-10-16
                                                                    Migrated from v1.4
                                                                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                    2019-10-16
                                                                    Updated compound(s) information (NPAtlas curation)
                                                                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                                    Entry version: 1

                                                                    Date
                                                                    Changes
                                                                    Submitters
                                                                    Reviewers
                                                                    2015-06-12
                                                                    Submitted
                                                                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
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