Genomic loci for this biosynthetic pathway

Cluster Type From To
The following clusters are from record BGC0000311.1:
Cluster 1NRP166669

BGC0000311, balhimycin biosynthetic gene cluster from Amycolatopsis balhimycina. Locus 1. Partial MIBiG entry.

Chemical compounds

Compound: balhimycin
PubChem ID: 16131414
SMILES string: Copy to clipboard
Molecular formula: C66H73Cl2N9O24
Average molecular mass: 1447.249 Da

Class-specific details

Biosynthetic class(es):
NRP

Gene cluster description

balhimycin (BGC0000311). Gene Cluster 1. Biosynthetic class = NRP. GenBank Y16952. Click on genes for more information.

Legend:

biosynthetic genes
transport-related genes
regulatory genes
other genes

Domain annotation

Homologous known gene clusters

Literature references

1. Pelzer S et al. (1999) Identification and analysis of the balhimycin biosynthetic gene cluster and its use for manipulating glycopeptide biosynthesis in Amycolatopsis mediterranei DSM5908. Antimicrob Agents Chemother 43(7):1565-73.
2. Pfeifer V et al. (2001) A polyketide synthase in glycopeptide biosynthesis: the biosynthesis of the non-proteinogenic amino acid (S)-3,5-dihydroxyphenylglycine. J Biol Chem 276(42):38370-7. doi: 10.1074/jbc.M106580200. Epub 2001
3. Bischoff D et al. (2001) The Biosynthesis of Vancomycin-Type Glycopeptide Antibiotics-The Order of the Cyclization Steps This work was supported by the Deutsche Forschungsgemeinschaft (SFB 323) and by a grant of the EU (MEGATOP, QLK3-1999-00650). R. D. S. gratefully acknowledges the support of a Feodor-Lynen Fellowship granted by the Alexander-von-Humboldt Stiftung. We thank Corina Bihlmaier and Volker Pfeifer for help with transformation and Southern hybridization, J. A. Moss (La Jolla (USA)) for critical comments on the manuscript and Prof. Dr. M. E. Maier and Prof. Dr. H.-P. Fiedler (Tubingen) for generous support. Angew Chem Int Ed Engl 40(24):4688-4691.
4. Puk O et al. (2002) Glycopeptide biosynthesis in Amycolatopsis mediterranei DSM5908: function of a halogenase and a haloperoxidase/perhydrolase. Chem Biol 9(2):225-35.
5. Recktenwald J et al. (2002) Nonribosomal biosynthesis of vancomycin-type antibiotics: a heptapeptide backbone and eight peptide synthetase modules. Microbiology 148(Pt 4):1105-18. doi: 10.1099/00221287-148-4-1105.