BGC0000311: balhimycin biosynthetic gene cluster from Amycolatopsis balhimycina DSM 5908
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Location: 1 - 66,669 nt. (total: 66,669 nt).
This entry is originally from NCBI GenBank Y16952.3.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
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Gene details
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General
Compounds
Genes
NRP
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0000311
Short description balhimycin biosynthetic gene cluster from Amycolatopsis balhimycina DSM 5908
Status Minimal annotation: no
A minimal annotation only contains information on the BGC loci and one or more linked chemical product(s)

Completeness: Unknown
Whether the loci encodes everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRP
Loci NCBI GenBank: Y16952.3
Compounds
  • balhimycin
Species Amycolatopsis balhimycina DSM 5908 [taxonomy]
References
Chemical products information
balhimycin
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C66H73Cl2N9O24
Chemical database entries
NPAtlas
PubCHEM
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • CAG25751.1
  • vanS
 1 - 759 (-) putative two-component system sensor kinase
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  • CAG25752.1
  • vanR
 770 - 1447 (-) putative two-component system response regulator
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  • CAG25753.1
  • vanY
 1537 - 2157 (+) putative VanY-type carboxypeptidase
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  • CAG25754.1
  • bbr
 3011 - 3976 (+) StrR family transcriptional regulator
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  • CAG25755.1
  • pdh
 4106 - 4981 (+) putative prephenate dehydrogenase
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  • CAG25756.1
  • abc
 5180 - 7135 (+) putative ABC transporter ATP-binding protein
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  • CAC48360.1
  • bpsA
 7138 - 16635 (+) peptide synthetase
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  • CAC48361.1
  • bpsB
 16635 - 28868 (+) peptide synthetase
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  • CAC48362.1
  • bpsC
 28888 - 34464 (+) peptide synthetase
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  • CAC48363.1
 34461 - 34670 (+) hypothetical protein
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  • CAA76547.1
  • oxyA
 34782 - 35957 (+) P450 monooxygenase
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  • CAA76548.1
  • oxyB
 36007 - 37203 (+) P450 monooxygenase
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  • CAA76549.1
  • oxyC
 37353 - 38573 (+) P450 monooxygenase
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  • CAA76550.1
  • bhaA
 38634 - 40109 (+) halogenase
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  • CAA76551.1
  • bgtfA
 40192 - 41382 (+) glycosyltransferase
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  • CAA76552.1
  • bgtfB
 41447 - 42676 (+) glycosyltransferase
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  • CAA76553.1
  • bgtfC
 42824 - 44053 (+) glycosyltransferase
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  • CAC48364.1
  • dvaC
 44087 - 45313 (+) putative C-3 methyl transferase
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  • CAC48365.1
 45409 - 46233 (+) hypothetical protein
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  • CAC48366.1
  • bmt
 46265 - 47119 (+) putative N-methyl transferase
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  • CAC48367.1
  • pgat
 47100 - 48404 (-) phenylglycine amino transferase
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  • CAC48368.1
  • bhp
 48610 - 49464 (+) putative hydrolase
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  • CAC48369.1
  • bpsD
 49530 - 51275 (+) peptide synthetase
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  • CAC48370.1
  • oxyD
 51289 - 52479 (+) putative P450 monooxygenase
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  • CAC48371.1
  • hmaS
 52645 - 53715 (+) putative hydroxyphenyl pyruvate dioxygenase
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  • CAC48372.1
  • hmo
 53712 - 54788 (+) putative phenylglycolate oxidase
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  • CAC48373.1
 54879 - 56237 (+) putative antiporter
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  • CAC48374.1
  • dvaA
 56501 - 57913 (+) putative NDP-hexose 2,3-dehydratase
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  • CAC48375.1
  • dvaE
 57915 - 58214 (+) putative 4-ketoreductase
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  • CAC48376.1
  • dvaB
 58211 - 59320 (+) putative C-3 amino transferase
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  • CAC48377.1
  • dvaD
 59344 - 59961 (+) putative 3,5 epimerase
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  • CAC48378.1
  • dpgA
 60179 - 61297 (+) dihydroxyphenylacetic acid synthase
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  • CAC48379.1
  • dpgB
 61294 - 61947 (+) putative enoyl-CoA hydratase
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  • CAC48380.1
  • dpgC
 61944 - 63248 (+) hydroxyacyl-dehydrogenase
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  • CAC48381.1
  • dpgD
 63245 - 64054 (+) putative enoyl-CoA-isomerase
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  • CAG25757.1
  • ald
 64162 - 65259 (+) putative alodlase
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  • CAG25758.1
  • pks
 65378 - >66669 (+) putative type I polyketide synthase
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NRP-specific information
Subclass N/A
Cyclic? no
NRP-synthases
Gene Modules
bpsA
Module ?
Specificity: leucine
Evidence for specificity:
Module ?
Specificity: R-beta-hydroxytyrosine
Evidence for specificity:
  • Structure-based inference
  • Feeding study
Module ?
Specificity: asparagine
Evidence for specificity:
bpsB
Module ?
Specificity: 4-hydroxyphenylglycine
Evidence for specificity:
  • ATP-PPi exchange assay
Module ?
Specificity: 4-hydroxyphenylglycine
Evidence for specificity:
  • ATP-PPi exchange assay
Module ?
Specificity: R-beta-hydroxytyrosine
Evidence for specificity:
  • ATP-PPi exchange assay
bpsC
Module ?
Specificity: 3,5-dihydroxyphenylglycine
Evidence for specificity:
  • ATP-PPi exchange assay
bpsD
Module ?
Specificity: tyrosine
Evidence for specificity:
  • Structure-based inference
  • Knock-out studies
  • Feeding study
Annotation changelog
MIBiG version Submitter Notes
1.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Submitted
2.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Migrated from v1.4
  • Updated compound(s) information (NPAtlas curation)
3.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Updated bioactivity data
  • Added NRP substrate specificities
3.1
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Update chemical activity to schema version 2.11
Detailed domain annotation
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