Genomic loci for this biosynthetic pathway

Cluster Type From To
The following clusters are from record BGC0000314.1:
Cluster 1NRP / Polyketide133868

BGC0000314, bromoalterochromides biosynthetic gene cluster from Pseudoalteromonas piscicida. Locus 1. Full MIBiG entry.

Chemical compounds

Compound: bromoalterochromide A
SMILES string: Copy to clipboard
Molecular formula: C38H50BrN7O10
Exact molecular mass: 844.2881 Da ([M+H]+)
Molecular activity: Antibacterial, Cytotoxic

Class-specific details

Biosynthetic class(es):
NRP / Polyketide
Cyclic depsipeptide (cyclic)
Thioesterase type:
Type I & II
Release / cyclization type:
Macrolactamization

Nonribosomal peptide synthetases:
altC (WP_010369400.1)
Module A0
A specificity: Coumaric acid
Evidence for specificity: Other
C domain subtype: N/A
altK (WP_010369425.1)
Module B1
A specificity: Threonine
Evidence for specificity: Sequence-based prediction
AA is epimerized
C domain subtype: LCL
altL (WP_010369428.1)
Module B2
A specificity: Valine
Evidence for specificity: Sequence-based prediction
AA is epimerized
C domain subtype: DCL
Module B3
A specificity: Asparagine
Evidence for specificity: Sequence-based prediction
C domain subtype: DCL
altM (WP_010369430.1)
Module B4
A specificity: Asparagine
Evidence for specificity: Sequence-based prediction
AA is epimerized
C domain subtype: LCL
Module B5
A specificity: Isoleucine
Evidence for specificity: Sequence-based prediction
AA is epimerized
C domain subtype: DCL

Modular polyketide synthases:
altD (WP_010369404.1)
Module A1
Scaffold-modifying domain: None
Module is iterated
Evidence for iteration: Unknown

Gene cluster description

bromoalterochromides (BGC0000314). Gene Cluster 1. Biosynthetic class = NRP/Polyketide. GenBank NZ_AHCC01000002, positions 204471-238338. Click on genes for more information.

Legend:

biosynthetic genes
transport-related genes
regulatory genes
other genes

Domain annotation

Homologous known gene clusters

General MIBiG information on this cluster

Complete gene cluster sequence?complete
Evidence for cluster-compound connection:Knock-out studies, Heterologous expression, Gene expression correlated with compound production, Sequence-based prediction
MIxS-compliance:Unknown
Contact for this cluster:Neha Garg (University of California at San Diego)

Literature references

1. Nguyen DD et al. (2013) MS/MS networking guided analysis of molecule and gene cluster families. Proc Natl Acad Sci U S A 110(28):E2611-20. doi:
2. Ross AC et al. (2015) Targeted capture and heterologous expression of the Pseudoalteromonas alterochromide gene cluster in Escherichia coli represents a promising natural product exploratory platform. ACS Synth Biol 4(4):414-20. doi: 10.1021/sb500280q. Epub 2014 Aug