BGC0000314: bromoalterochromide A biosynthetic gene cluster from Pseudoalteromonas piscicida JCM 20779
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Location: 204,471 - 238,338 nt. (total: 33,868 nt).
This entry is originally from NCBI GenBank NZ_AHCC01000002.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
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Gene details
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General
Compounds
Genes
Polyketide
NRP
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0000314
Short description bromoalterochromide A biosynthetic gene cluster from Pseudoalteromonas piscicida JCM 20779
Status Minimal annotation: no
A minimal annotation only contains information on the BGC loci and one or more linked chemical product(s)

Completeness: complete
Whether the loci encodes everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRP (Cyclic depsipeptide)
  • Polyketide
  • Other (Aminocoumarin)
Loci NCBI GenBank: NZ_AHCC01000002.1
Compounds
  • bromoalterochromide A
Species Pseudoalteromonas piscicida JCM 20779 [taxonomy]
References
Chemical products information
bromoalterochromide A
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C38H50Br1N7O10
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • PpisJ2_010100002366
  • WP_010369397.1
 204471 - 206090 (+) aromatic amino acid ammonia-lyase
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  • PpisJ2_010100002371
  • WP_010369398.1
 206228 - 206521 (+) phosphopantetheine-binding protein
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  • PpisJ2_010100002376
  • WP_010369400.1
 206556 - 208052 (+) AMP-binding protein
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  • PpisJ2_010100002381
  • WP_010369404.1
 208045 - 210228 (+) beta-ketoacyl-[acyl-carrier-protein] synthase family protein
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  • PpisJ2_010100002386
  • WP_010369407.1
 210230 - 210997 (+) ABC transporter ATP-binding protein
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  • PpisJ2_010100002391
  • WP_010369409.1
 210990 - 212105 (+) ABC transporter permease
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  • PpisJ2_010100002396
  • WP_010369411.1
 212102 - 212500 (+) 3-hydroxyacyl-ACP dehydratase FabZ
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  • PpisJ2_010100002401
  • WP_010369414.1
 212512 - 213243 (+) SDR family oxidoreductase
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  • PpisJ2_010100002406
  • WP_010369417.1
 213240 - 213947 (+) hypothetical protein
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  • PpisJ2_010100002411
  • WP_010369421.1
 213944 - 214699 (+) alpha/beta fold hydrolase
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  • PpisJ2_010100002416
  • WP_010369425.1
 214723 - 219276 (+) non-ribosomal peptide synthetase
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  • PpisJ2_010100002421
  • WP_010369428.1
 219280 - 227127 (+) non-ribosomal peptide synthetase
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  • PpisJ2_010100002426
  • WP_010369430.1
 227130 - 236972 (+) non-ribosomal peptide synthetase
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  • PpisJ2_010100002431
  • WP_010369433.1
 237100 - 238338 (+) tryptophan 7-halogenase
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Polyketide-specific information
Subclass Unknown
Cyclic? no
Polyketide-synthases
Genes Properties Modules
PpisJ2_010100002381 Synthase subclass:
Module A1
Genes: PpisJ2_010100002381
Core domains: Ketosynthase
Non-canonical activity:
  • Iterated
Evidence for non-canonical activity:
  • Structure-based inference
NRP-specific information
Subclass Cyclic depsipeptide
Cyclic? yes
Release type
  • Macrolactamization
NRP-synthases
Gene Modules
PpisJ2_010100002376
Module A0
Specificity: coumaric acid
Evidence for specificity:
PpisJ2_010100002416
Module B1
Specificity: threonine
Evidence for specificity:
  • Structure-based inference
Condensation domain type: LCL
PpisJ2_010100002421
Module B2
Specificity: valine
Evidence for specificity:
  • Sequence-based prediction
Condensation domain type: DCL
Module B3
Specificity: asparagine
Evidence for specificity:
  • Sequence-based prediction
Condensation domain type: DCL
PpisJ2_010100002426
Module B4
Specificity: asparagine
Evidence for specificity:
  • Sequence-based prediction
Condensation domain type: LCL
Module B5
Specificity: isoleucine
Evidence for specificity:
  • Sequence-based prediction
Condensation domain type: DCL
Annotation changelog
MIBiG version Submitter Notes
1.0
  • Hidden contributor (ID: UK5BZZ5BLXFR5LGS2GITT5IB, no GDPR consent given).
  • Submitted
2.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Migrated from v1.4
3.0
  • Hidden contributor (ID: 3UOU7PODQJXIM6BEPUHHRRA5, no GDPR consent given).
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Update NCBI taxid after old taxid was merged
  • Corrected NRP module activity
  • Removed ketoreductase stereochemistry annotation from modules without ketoreductases
  • Updated NRP substrate specificities
3.1
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Update chemical activity to schema version 2.11
Detailed domain annotation
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