BGC0000315 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0000315 (Streptomyces coelicolor A3(2))

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	NRPS	1	82,872	CDA1b/CDA2a/CDA2b/CDA3a/CDA3b/CDA4a/CDA4b	NRPS:Type I	100%

BGC0000315 - Region 1 - NRPS

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Location: 1 - 82,872 nt. (total: 82,872 nt) Show pHMM detection rules used

Region on contig edge.

NRPS: cds(Condensation and (AMP-binding or A-OX))

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

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Gene details

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Gene overview

MIBiG

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 82,873
Label		BGC0000315

Detailed domain annotation

Selected features only

Show module domains

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000315	1.00	NRP	CDA1b, CDA2a, CDA2b, CDA3a, CDA3b, CDA4a, CDA4b	Streptomyces coelicolor A3(2)
BGC0001370	0.45	NRP	lipopeptide 8D1-1, lipopeptide 8D1-2	Streptomyces rochei
BGC0001133	0.45	NRP	taxlllaid A	Xenorhabdus bovienii SS-2004
BGC0001050	0.38	NRP, Polyketide	thalassospiramide A	Tistrella bauzanensis
BGC0002071	0.37	NRP	virginiafactin A, virginiafactin B, virginiafactin C, virginiafactin D	Pseudomonas sp. QS1027
BGC0002017	0.36	NRP	potensibactin	Nocardiopsis potens DSM 45234
BGC0001185	0.35	NRP	bacillibactin	Bacillus velezensis FZB42
BGC0001844	0.35	NRP	holrhizin	Paraburkholderia rhizoxinica HKI 454
BGC0000417	0.35	NRP	rhodochelin	Rhodococcus jostii RHA1
BGC0001833	0.35	NRP	icosalide A, icosalide B	Burkholderia gladioli

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000315	1.00	NRP	CDA1b, CDA2a, CDA2b, CDA3a, CDA3b, CDA4a, CDA4b	Streptomyces coelicolor A3(2)
BGC0001133	0.75	NRP	taxlllaid A	Xenorhabdus bovienii SS-2004
BGC0001370	0.73	NRP	lipopeptide 8D1-1, lipopeptide 8D1-2	Streptomyces rochei
BGC0001050	0.70	NRP, Polyketide	thalassospiramide A	Tistrella bauzanensis
BGC0002071	0.70	NRP	virginiafactin A, virginiafactin B, virginiafactin C, virginiafactin D	Pseudomonas sp. QS1027
BGC0002017	0.69	NRP	potensibactin	Nocardiopsis potens DSM 45234
BGC0001844	0.68	NRP	holrhizin	Paraburkholderia rhizoxinica HKI 454
BGC0000417	0.68	NRP	rhodochelin	Rhodococcus jostii RHA1
BGC0001833	0.68	NRP	icosalide A, icosalide B	Burkholderia gladioli
BGC0001758	0.68	NRP	rhizomide A, rhizomide B, rhizomide C	Paraburkholderia rhizoxinica HKI 454

Similar known gene clusters from MIBiG 4.0

Module view

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NRPS/PKS products

NRPS/PKS substrates

Predicted core structure(s)

For candidate cluster 1, location 3886 - 82872:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (Ser - Thr - D-Trp - Asp - Asp - D-Hpg) + (Asp - Gly - D-Asn) + (Glu - Trp)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

SCO3230

Search NORINE for peptide: strict or relaxed

AMP-binding (475..883): Ser

nrpys: Ser

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Aliphatic chain or phenyl group with -OH (Ser, Thr, Dhpg, Hpg)
Small clusters prediction:: ser (Ser)
Single AA prediction:: ser (Ser)

Stachelhaus prediction details:

Stachelhaus sequence:: DVWHFSLVDK
Nearest Stachelhaus code(s):: Ser DVWHFSLVDK (100% 8Å match); Ala or Ser DVWHFSLVDK (97% 8Å match)
Stachelhaus code match:: 100% (strong)

AMP-binding (1674..2097): Thr

nrpys: Thr

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Aliphatic chain or phenyl group with -OH (Ser, Thr, Dhpg, Hpg)
Small clusters prediction:: thr (Thr)
Single AA prediction:: thr (Thr)

Stachelhaus prediction details:

Stachelhaus sequence:: DFWNVGMVHK
Nearest Stachelhaus code(s):: Thr DFWNVGMVHK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

AMP-binding (2759..3160): Trp

nrpys: Trp

SVM prediction details:

Predicted physicochemical class:: N/A
Large clusters prediction:: Aromatic side chain (Phe, Trp, Ph-Gly, Tyr, bOH-Tyr)
Small clusters prediction:: Unpolar aromatic ring (Phe, Trp)
Single AA prediction:: trp (Trp)

Stachelhaus prediction details:

Stachelhaus sequence:: DAWSVGSVCK
Nearest Stachelhaus code(s):: Trp DAWSVGSVCK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

AMP-binding (4283..4657): Asp

nrpys: Asp

SVM prediction details:

Predicted physicochemical class:: hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
Large clusters prediction:: Aliphatic chain with H-bond donor (Asp, Asn, Glu, Gln, Aad)
Small clusters prediction:: asp,asn (Asp, Asn)
Single AA prediction:: asp (Asp)

Stachelhaus prediction details:

Stachelhaus sequence:: DLTKIGAVNK
Nearest Stachelhaus code(s):: Asp DLTKIGAVNK (100% 8Å match); OH-Asp or OMe-Asp DLTKIGAVNK (76% 8Å match)
Stachelhaus code match:: 100% (strong)

AMP-binding (5323..5697): Asp

nrpys: Asp

SVM prediction details:

Predicted physicochemical class:: hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
Large clusters prediction:: Aliphatic chain with H-bond donor (Asp, Asn, Glu, Gln, Aad)
Small clusters prediction:: asp,asn (Asp, Asn)
Single AA prediction:: asp (Asp)

Stachelhaus prediction details:

Stachelhaus sequence:: DLTKIGAVNK
Nearest Stachelhaus code(s):: Asp DLTKIGAVNK (100% 8Å match); OH-Asp or OMe-Asp DLTKIGAVNK (76% 8Å match)
Stachelhaus code match:: 100% (strong)

AMP-binding (6360..6777): Hpg

nrpys: Hpg

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Aliphatic chain or phenyl group with -OH (Ser, Thr, Dhpg, Hpg)
Small clusters prediction:: Polar, uncharged (hydroxy-phenyl) (Dhpg, Hpg)
Single AA prediction:: hpg (Hpg)

Stachelhaus prediction details:

Stachelhaus sequence:: DVYHLGLLCK
Nearest Stachelhaus code(s):: Hpg DVYHLGLLCK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

SCO3231

Search NORINE for peptide: strict or relaxed

AMP-binding (472..845): Asp

nrpys: Asp

SVM prediction details:

Predicted physicochemical class:: hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
Large clusters prediction:: Aliphatic chain with H-bond donor (Asp, Asn, Glu, Gln, Aad)
Small clusters prediction:: asp,asn (Asp, Asn)
Single AA prediction:: asp (Asp)

Stachelhaus prediction details:

Stachelhaus sequence:: DLTKIGAVNK
Nearest Stachelhaus code(s):: Asp DLTKIGAVNK (100% 8Å match); OH-Asp or OMe-Asp DLTKIGAVNK (76% 8Å match)
Stachelhaus code match:: 100% (strong)

AMP-binding (1504..1884): Gly

nrpys: Gly

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
Small clusters prediction:: Tiny, hydrophilic, transition to aliphatic (Gly, Ala)
Single AA prediction:: gly (Gly)

Stachelhaus prediction details:

Stachelhaus sequence:: DILQLGLIWK
Nearest Stachelhaus code(s):: Gly DILQLGLIWK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

AMP-binding (2567..2973): Asn

nrpys: Asn

SVM prediction details:

Predicted physicochemical class:: hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
Large clusters prediction:: Aliphatic chain with H-bond donor (Asp, Asn, Glu, Gln, Aad)
Small clusters prediction:: asp,asn (Asp, Asn)
Single AA prediction:: asn (Asn)

Stachelhaus prediction details:

Stachelhaus sequence:: DLTKVGEVGK
Nearest Stachelhaus code(s):: Asn DLTKVGEVGK (100% 8Å match); OH-Asn DLTKVGEVGK (79% 8Å match); Trp DLTKVGEVGK (76% 8Å match)
Stachelhaus code match:: 100% (strong)

SCO3232

Search NORINE for peptide: strict or relaxed

AMP-binding (467..874): Glu

nrpys: Glu

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
Small clusters prediction:: asp,asn (Asp, Asn)
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DQGKTGVGHK
Nearest Stachelhaus code(s):: Glu DQGKTGVGHK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

AMP-binding (1541..1936): Trp

nrpys: Trp

SVM prediction details:

Predicted physicochemical class:: N/A
Large clusters prediction:: Aromatic side chain (Phe, Trp, Ph-Gly, Tyr, bOH-Tyr)
Small clusters prediction:: Unpolar aromatic ring (Phe, Trp)
Single AA prediction:: trp (Trp)

Stachelhaus prediction details:

Stachelhaus sequence:: DGWAVASVCK
Nearest Stachelhaus code(s):: Trp DGWAVASVCK (100% 8Å match)
Stachelhaus code match:: 100% (strong)