ID BGC0000315; SV 1; ; DNA; ; UNC; 82872 BP. XX AC BGC0000315; XX DE Calcium-dependent antibiotic biosynthetic gene cluster XX KW complete genome XX OS Streptomyces coelicolor A3(2) OC Bacteria; Actinobacteria; Actinobacteridae; Actinomycetales; OC Streptomycineae; Streptomycetaceae; Streptomyces; Streptomyces albidoflavus OC group. XX CC MIBiG: Minimum Information about a Biosynthetic Gene cluster CC This entry originates from the region between 3519449-3602320 nt CC from GenBank ID AL645882.2. XX FH Key Location/Qualifiers FT gene complement(1..1455) FT /gene="SCO3210" FT /gene_synonym="SCE8.03c" FT CDS complement(1..1455) FT /product="putative 2-dehydro-3-deoxyheptonate aldolase" FT /codon_start=1 FT /gene_synonym="SCE8.03c" FT /transl_table=11 FT /note="SCE8.03c, aro, probable 2-dehydro-3-deoxyheptonate FT aldolase, len: 484 aa; similar to many e.g. TR:O52308 FT (EMBL:AF035756) 2-dehydro-3-deoxyheptonate aldolase from FT Streptomyces sp. fasta scores; opt: 1619, z-score: 1722.0, FT E(): 0, (54.5% identity in 440 aa overlap) and FT SW:AROF_ARATH phospho-2-dehydro-3-deoxyheptonate aldolase 1 FT from Arabidopsis thaliana (525 aa) fasta scores; opt: 1457, FT z-score: 1549.2, E(): 0, (48.4% identity in 457 aa FT overlap)." FT /db_xref="GI:4490619" FT /db_xref="GOA:Q9Z4X1" FT /db_xref="InterPro:IPR002480" FT /db_xref="UniProtKB/TrEMBL:Q9Z4X1" FT /translation="MTASDTYTQPRTAPAGTGTAAPGPTGPAADAGRGGWTPGSWRSRP FT AAQQPEWPDPGELRGVEDTLALRPPLVLPDEILDLRRSLAQVAAGEGFLLQAGDCAERF FT GSCTEAGVRGKLRVILQVAILLTYGSGLPVVKVGRIAGQFGKPRSRPTEAVDGVELPVY FT RGDIVNGPEFTAEARRPDAGRLLSAYHHASAALNVLRALTLGGYADLGQVHEWNQEFVR FT RSPAGQRYEKAADDITWALRFMSACGLDTRSQAALHQVQLYTSHEALLPQYEQALIRYD FT EKRRGWFDTSAHLLWIGDRTRRVDGAHVELLAGVDNPVGVKVGPTMGVDDLRELCERLD FT PDRAPGRLVLISRLGAGRGAELLPPLLRAVRDAGHAPVWACDPMHGNTFVSASGYKTRR FT LSDITTEVAEFFAVHREEGLHPGGIHLELTGDDVTECLGGDLDEVLDTHLASRYETACD FT PRLNAAQSIELAFGVARLLRELRGGA" FT /gene="SCO3210" FT /protein_id="CAB38581.1" FT source 1..82872 FT /strain="A3(2)" FT /mol_type="genomic DNA" FT /organism="Streptomyces coelicolor A3(2)" FT /db_xref="taxon:100226" FT cluster 1..82872 FT /note="Cluster number: 1" FT /note="Detection rule(s) for this cluster type: nrps: FT ((Condensation & AMP-binding) or (Condensation & A-OX) or FT cluster(Condensation,AMP-binding));" FT /note="Structure image: structures/compound1.png; FT structures/compound2.png; structures/compound3.png; FT structures/compound4.png; structures/compound5.png; FT structures/compound6.png; structures/compound7.png; " FT /product="nrps" FT gene complement(1452..2228) FT /gene="SCO3211" FT /gene_synonym="SCE8.04c" FT /gene_synonym="trpC2" FT CDS complement(1452..2228) FT /product="putative indoleglycerol phosphate synthase" FT /codon_start=1 FT /gene_synonym="SCE8.04c" FT /gene_synonym="trpC2" FT /transl_table=11 FT /note="SCE8.04c, trpC2, probable indoleglycerol phosphate FT synthase, len: 258aa; similar to many inluding another from FT Streptomyces coelicolor TR:O68814 (EMBL:AF054585) located FT in the trpCBA locus which maps (by hybridisation) to the FT overlap between cosmids 3A3 and 4G6 (269 aa) fasta scores; FT opt: 652, z-score: 740.9, E(): 0, (47.2% identity in 254 aa FT overlap). Also similar to SW:TRPC_PSEAE trpC, probable FT indoleglycerol phosphate synthase from Pseudomonas FT aeruginosa (278 aa) fasta scores; opt: 632, z-score: 718.3, FT E(): 1.1e-32, (43.5% identity in 260 aa overlap). Contains FT Pfam match to entry PF00218 IGPS, Indole-3-glycerol FT phosphate synthases, score 316.20, E-value 3.8e-91." FT /db_xref="GI:4490620" FT /db_xref="GOA:Q9Z4X0" FT /db_xref="InterPro:IPR001468" FT /db_xref="InterPro:IPR011060" FT /db_xref="InterPro:IPR013785" FT /db_xref="InterPro:IPR013798" FT /db_xref="UniProtKB/Swiss-Prot:Q9Z4X0" FT /translation="MSGILAGLVAEAESQTGRRRALRTEAKLTELAAAAPPARDFAAAL FT REPGLAVIAEMKPRSPSKGPLTDDYRPAELARAYQGGGAHAVSVLTHEAGFGGSPDHLA FT VARAACELPVLRKDFVVDEYQILEARALGADALLLIVAALAPARLAALLARTRACGMEA FT LVEVHDEREVDVALEAGADVIGVNHRDLRDFSIDRTLSARLRGRVGTGRVMVGESGVRG FT APDARALEAAGVDAVLVGELLMRAGDPGTTIKGLVG" FT /gene="SCO3211" FT /protein_id="CAB38582.1" FT misc_feature complement(1461..2126) FT /note="Pfam match to entry PF00218 IGPS, Indole-3-glycerol FT phosphate synthases, score 316.20, E-value 3.8e-91." FT /gene="SCO3211" FT /gene_synonym="SCE8.04c" FT /gene_synonym="trpC2" FT gene complement(2225..3232) FT /gene="SCO3212" FT /gene_synonym="SCE8.05c" FT /gene_synonym="trpD2" FT CDS complement(2225..3232) FT /product="probable anthranilate phosphoribotransferase" FT /codon_start=1 FT /gene_synonym="SCE8.05c" FT /gene_synonym="trpD2" FT /transl_table=11 FT /note="SCE8.05c, trpD2, anthranilate FT phosphoribotransferase, len: 335 aa; similar to many e.g. FT SW:TRPD_AZOBR TrpD, anthranilate phosphoribotransferase FT from Azospirillum brasilense (355 aa) fasta scores; opt: FT 924, z-score: 1056.6, E(): 0, (49.5% identity in 315 aa FT overlap). Contains Pfam match to entry PF00591 FT Glycos_transf_3, glycosyl transferase family, score 223.70, FT E-value 2.8e-63." FT /db_xref="GI:4490621" FT /db_xref="GOA:Q9Z4W9" FT /db_xref="InterPro:IPR000312" FT /db_xref="InterPro:IPR005940" FT /db_xref="InterPro:IPR017459" FT /db_xref="InterPro:IPR020072" FT /db_xref="UniProtKB/Swiss-Prot:Q9Z4W9" FT /translation="MQRPLTEAEAADAMRVIMRGEATAAQIAAFALAVTVRGASADNLA FT GMARAAQEFATPVPRAGGDLLDTCGTGGDGLNTFNISTAAAIVAAACGVRVAKHGNRSA FT SSACGSADVLEELGVRIDLGAEEAAACLDRTGITFLFAPVFHPAFRHTAGPRRELGART FT VFNLLGPLCNPSGARLRTLGVPSRELVEPMTEVLERLGVTRALVFHSADGMDELSTAAP FT AHLVELRDGRRTTHRFDPAEHGLARSRPGDLAGGDRAVNAAVLRRVLAGGRGPARDVVL FT LNAAAALRVAGVAGTWSDGLRLAASAVDGGAAAGLLDRWAHASWQRADLVEVPA" FT /gene="SCO3212" FT /protein_id="CAB38583.1" FT misc_feature complement(2804..3229) FT /note="Pfam match to entry PF00591 Glycos_transf_3, FT glycosyl transferase family, score 223.70, E-value FT 2.8e-63." FT /gene="SCO3212" FT /gene_synonym="SCE8.05c" FT /gene_synonym="trpD2" FT gene complement(3249..3851) FT /gene="SCO3213" FT /gene_synonym="SCE8.06c" FT /gene_synonym="trpG" FT CDS complement(3249..3851) FT /product="probable anthranilate synthase component II" FT /codon_start=1 FT /gene_synonym="SCE8.06c" FT /gene_synonym="trpG" FT /transl_table=11 FT /note="SCE8.06c, trpG, anthranilate synthase component II, FT len: 200aa; similar to many eg. TR:G4185545 (EMBL:AF108766) FT TrpG, anthranilate synthase component II, from Rhodobacter FT sphaeroides (195 aa) fasta scores; opt: 728, z-score: FT 825.0, E(): 0, (60.2% identity in 186 aa overlap). Contains FT matches to Pfam entry PF00117 GATase, Glutamine FT amidotransferases class-I, score 332.60, E-value 4.3e-96 FT and Prosite PS00442 Glutamine amidotransferases class-I FT active site." FT /note="smCOG: FT SMCOG1249:carbamoyl_phosphate_synthase_small_subunit FT (Score: 137.5; E-value: 8.4e-42);" FT /db_xref="GI:4490622" FT /db_xref="GOA:Q9Z4W8" FT /db_xref="HSSP:1I1Q" FT /db_xref="InterPro:IPR000991" FT /db_xref="InterPro:IPR001317" FT /db_xref="InterPro:IPR006220" FT /db_xref="InterPro:IPR006221" FT /db_xref="InterPro:IPR011702" FT /db_xref="InterPro:IPR017926" FT /db_xref="UniProtKB/TrEMBL:Q9Z4W8" FT /translation="MSAPTGTRAGAAPRVAVIDNYDSFTYNLVHYVAELGGRPTVFRND FT AVTVAELAGFDLLLLSPGPGTPAGAGICVDAVRALGARLPVLGVCLGHQAVAVAYGGSV FT VRGEQVHGKASAVHHDGGGVFAGLPDPFSATRYHSLVVEPAGLPDELTVTARTADGTVM FT GLRHRTHPVHGVQFHPESVLSPEGKQLIANFLECADD" FT /gene="SCO3213" FT /protein_id="CAB38584.1" FT misc_feature complement(3261..3812) FT /note="Pfam match to entry PF00117 GATase, Glutamine FT amidotransferases class-I, score 332.60, E-value 4.3e-96" FT /gene="SCO3213" FT /gene_synonym="SCE8.06c" FT /gene_synonym="trpG" FT misc_feature complement(3564..3599) FT /note="PS00442 Glutamine amidotransferases class-I active FT site." FT /gene="SCO3213" FT /gene_synonym="SCE8.06c" FT /gene_synonym="trpG" FT gene complement(3848..5383) FT /gene="SCO3214" FT /gene_synonym="SCE8.07c" FT /gene_synonym="trpE2" FT CDS complement(3848..5383) FT /product="probable anthranilate synthase component I" FT /codon_start=1 FT /gene_synonym="SCE8.07c" FT /gene_synonym="trpE2" FT /transl_table=11 FT /note="SCE8.07c, trpE2, anthranilate synthase component I, FT len: 511aa; similar to many eg. SW:TRPE_PSEPU TrpE, FT anthranilate synthase component I from Pseudomonas putida FT (493 aa) fasta scores; opt: 1173, z-score: 1253.8, E(): 0, FT (44.3% identity in 492 aa overlap). Contains Pfam match to FT entry PF00425 chorismate_bind, chorismate binding enzyme, FT score 529.40, E-value 2.5e-155." FT /note="smCOG: SMCOG1018:isochorismate_synthase (Score: FT 385.7; E-value: 6.2e-117);" FT /db_xref="GI:4490623" FT /db_xref="GOA:Q9Z4W7" FT /db_xref="InterPro:IPR005256" FT /db_xref="InterPro:IPR005801" FT /db_xref="InterPro:IPR006805" FT /db_xref="InterPro:IPR015890" FT /db_xref="InterPro:IPR019999" FT /db_xref="UniProtKB/Swiss-Prot:Q9Z4W7" FT /translation="MTTHAAEAPTTDPQGAPGSQKTPDATEAEEAARATVPHRAAAAAL FT AREHDVVPLHQEFLDDSVSPVTAFAQLCGPDEAGFLLESVPVSGGVARYSYVGHRPVPL FT EPTGGDPLTALRSHLARSVAPVPGLPPFHGGVVGYLGYEAARHFEDLPLAAGPPPGLPE FT SAFLAADDLVVFDHATRRVLLMTLYRPARESYDDAVARIVRLNRALRRAPAPAAFSGRP FT LAAATPADHGTQGWTANLTEAQFTERVARAREHIAAGDAFQIVLSRRLSRPLRARPTDL FT YRHLRATNPSPYMYHLSLGGGRHVIGASPELLVKAEGRTVRTRPLAGTRPRHPDPAEDL FT RLERELRADEKERAEHVMLVDLGRNDLGRVTEPGTVRVERLMRVERFSHVMHLSSTVRG FT RLAEGRDALDALRSAFPAGTLSGAPKIRAMEIIAELEPEQRGVYGGALGFVGADGLTDF FT AIALRTMVVADGHVHVQAGAGIVADSDPAAEFRETLHKSRAMLTAVRRAEAAA" FT /gene="SCO3214" FT /protein_id="CAB38585.1" FT misc_feature complement(3872..4663) FT /note="Pfam match to entry PF00425 chorismate_bind, FT chorismate binding enzyme, score 529.40, E-value 2.5e-155" FT /gene="SCO3214" FT /gene_synonym="SCE8.07c" FT /gene_synonym="trpE2" FT gene complement(5380..6396) FT /gene="SCO3215" FT /gene_synonym="SCE8.08c" FT CDS complement(5380..6396) FT /product="hypothetical protein" FT /codon_start=1 FT /gene_synonym="SCE8.08c" FT /transl_table=11 FT /note="SCE8.08c, unknown, len: 338 aa" FT /note="smCOG: SMCOG1089:methyltransferase (Score: 57.7; FT E-value: 2.1e-17);" FT /db_xref="GI:4490624" FT /db_xref="GOA:Q9Z4W6" FT /db_xref="InterPro:IPR013216" FT /db_xref="UniProtKB/TrEMBL:Q9Z4W6" FT /translation="MTGDDVQGQLAELRRSHPELHALADPRRIAAWEAARGSAPGRHDD FT FGADGEGSRGVEYVQAQALNRRARETGIRKLLGFAETARRTAAGDRPVLVDLLGGDGLV FT RKVCEELGIGDFNILTCDASPHMVTTAWAAGVPALLQRAEQPLLRDHSVDAVLLAYGSH FT HVPSSDRQTVATEARRMLRPGGTFVLHDFLVGSPVDVWFEEVTDVYSATGHKFLHFTRD FT EIEGYLEKAGYDHREVVEIDDPYTAVAATPEEAELEIGRYLLNMYGLVKVFEGRTEQEA FT YRWVAETAKAVFRYPDAEGGLASSELRQEGTGGWRVTIPRRAVVGVGRVSATAGKAA" FT /gene="SCO3215" FT /protein_id="CAB38586.1" FT gene 6689..9079 FT /gene="SCO3216" FT /gene_synonym="SCE8.09" FT CDS 6689..9079 FT /product="putative integral membrane ATPase" FT /codon_start=1 FT /gene_synonym="SCE8.09" FT /transl_table=11 FT /note="SCE8.09, probable integral membrane ATPase, len: 796 FT aa; member of a large family including SW:Y1B2_MYCTU FT putative cation-transporting ATPase from Mycobacterium FT tuberculosis (797 aa) fasta scores; opt: 2741, z-score: FT 2896.9, E(): 0, (56.8% identity in 791 aa overlap). FT Contains two Pfam matches to entry PF00122 E1-E2_ATPase, FT E1-E2 ATPases, score 109.40, E-value 9.7e-30 and score FT 155.80, E-value 7.3e-43, and Prosite match to PS00154 E1-E2 FT ATPases phosphorylation site." FT /note="smCOG: FT SMCOG1037:heavy_metal_translocating_P-type_ATPase (Score: FT 464.6; E-value: 1e-140);" FT /db_xref="GI:4490625" FT /db_xref="GOA:Q9Z4W5" FT /db_xref="InterPro:IPR000695" FT /db_xref="InterPro:IPR001757" FT /db_xref="InterPro:IPR005834" FT /db_xref="InterPro:IPR008250" FT /db_xref="InterPro:IPR018303" FT /db_xref="UniProtKB/TrEMBL:Q9Z4W5" FT /translation="MKNQLDEPGGAVRVGGGGGLSAAEVAERVAAGQVNDVPARSSRTI FT GEIVRSNLFTRINAIIGVLFVIVMIVGPVQDGLFGGVILANTAIGIIQEVRAKRTLDQL FT AIVGESRPRVWRDGQRLELSASEIVIDDSIDLGQGDKIVVDGTVTSGDSLEVDESLLTG FT EADPVVKQPGDPVMSGSFVVAGSGTFTATRVGKEAYASQLADEARRFSLVNSELRNGID FT RILKFVTYAIVPAGIALIITQFVVNDDNFSEAIRRMVGGLVPMVPEGLVLLTSLAFAVG FT VVRLGKKQCLVQELPAIEGLARVDTVCLDKTGTLTEASMDVDEVLPLLPELPVDAVLGA FT LGAADERPNASLQAIIESYPAPEGWRRTATAPFSSARRWSGASFAEPSGTESAWLLGAP FT DTMLPAGHSVLTAADSYGARGLRVLLLARSDRPLDTLMDDPAAVPAAVTAAALVVIKQR FT VRPEARATLDYFADQGVTAKVISGDNAVSVGAVASSLSLPGAERPVDARFLPDEPAELA FT DAVEENTVFGRVGPQQKRDMVGALQSRGHTVAMTGDGVNDVLALKDADIGVGMGSGSPA FT TRAVAQIVLLNNNFSALPSVVAEGRRVIGNIERVANLFLTKTVYSVLMALVVVIAQVPY FT PFLPRHITLVGSLTIGIPAFFLALAPNKERARSNFVGRVLRFAIPAGALAAAATSVAYL FT IARSVYDDNLDAETSAATLALFLTALWALAVIARPYTWWRVLLVLTMAVGFAVVLVVPY FT LQEFFQLKLVGVTAPWAAVACAAVAGLVLELVWARMRRRLDAD" FT /gene="SCO3216" FT /protein_id="CAB38587.1" FT misc_feature 6917..7672 FT /note="Pfam match to entry PF00122 E1-E2_ATPase, E1-E2 FT ATPases, score 155.80, E-value 7.3e-43" FT /gene="SCO3216" FT /gene_synonym="SCE8.09" FT misc_feature 7616..7636 FT /note="PS00154 E1-E2 ATPases phosphorylation site." FT /gene="SCO3216" FT /gene_synonym="SCE8.09" FT misc_feature 8063..8671 FT /note="Pfam match to entry PF00122 E1-E2_ATPase, E1-E2 FT ATPases, score 109.40, E-value 9.7e-30" FT /gene="SCO3216" FT /gene_synonym="SCE8.09" FT gene 9824..11740 FT /gene="SCO3217" FT /gene_synonym="cdaR" FT /gene_synonym="SCE8.10" FT CDS 9824..11740 FT /product="putative transcriptional regulator" FT /codon_start=1 FT /gene_synonym="cdaR" FT /gene_synonym="SCE8.10" FT /transl_table=11 FT /note="SCE8.10, cdaR, transcriptional activator protein, FT len: 638 aa; Previously sequenced and therefore identical FT to CdaR (EM:AF124138) transcriptional activator protein for FT the CDA biosynthesis cluster in Streptomyces coelicolor. FT Also similar to many including SW:AFSR_STRCO AfsR, a global FT regulatory protein for secondary metabolite formation in FT Streptomyces coelicolor A3(2) (993 aa) fasta scores; opt: FT 972, z-score: 1087.1, E(): 0, (36.6% identity in 610 aa FT overlap) and SW:REDD_STRCO regulator of undecylprodigiosin FT production in Streptomyces coelicolor A3(2) (350 aa) fasta FT scores; opt: 382, z-score: 432.2, E(): 9.1e-17, (32.6% FT identity in 258 aa overlap). Contains match to PS00017 FT ATP/GTP-binding site motif A (P-loop)." FT /note="smCOG: FT SMCOG1041:transcriptional_regulator,_SARP_family (Score: FT 596.4; E-value: 1.8e-180);" FT /db_xref="GI:4490626" FT /db_xref="GOA:Q9Z389" FT /db_xref="InterPro:IPR000767" FT /db_xref="InterPro:IPR001867" FT /db_xref="InterPro:IPR002182" FT /db_xref="InterPro:IPR003593" FT /db_xref="InterPro:IPR005158" FT /db_xref="InterPro:IPR011990" FT /db_xref="InterPro:IPR011991" FT /db_xref="InterPro:IPR016032" FT /db_xref="UniProtKB/TrEMBL:Q9Z389" FT /translation="MDLRLIEPIYQRIGNAEVSQKETPTAGLEFGVLGPLEVHMNGRGL FT TVGGPRQRAVLSALLLSANQVVSFDSLIEEVWNGRPPSTARTQVAICIATLRKIFRTAG FT WEQETIITATPGYMLSLAGHSLDSLRFEQLVSRATELTADERPAPAAEALRQALALWRG FT PALGGVHAPFAETEAARLDEQRMLAVEQHMALRLQLGEHQSVLGELQALVGACPLRDRL FT RYYLMLAQYRSGRRAEALTTFRDGMRYSIEEIGLELGTDLQSLHDSILRDEFPQLGVLG FT IAAARKDRQQTVPSQLPESDAYFIGRSREQWLMDDVLLDGSAQNPPAIAYLTGSPGIGK FT TSLAVNWAHRAAHRFPDGQLFADLREGGPLEVLHQFLRQLGDEGPLPAEPAEAAERYRG FT LLEGRRVLIVLDHASSYAQVRHLLPTSGGCCVLITGRANLDELMQKYRTFRLRVAPLSD FT DEARETLAGVLRDSRAQDVPEATSRLAALCGHSPLALRAAAARLLTKTHWRVLDLVCRL FT ERSGDRLTALSIGEDSLRARLDRSMRELDPRVAFAYRELSRLGDADFDAEQAAQVLGTD FT LLEAEDLIETLVDAQLLEAVGRSRWGGMRFKWQELVRLHASHCLTAAGSLETPAPVAVA FT LTD" FT /gene="SCO3217" FT /protein_id="CAB38588.1" FT misc_feature 10823..10846 FT /note="PS00017 ATP/GTP-binding site motif A (P-loop)." FT /gene="SCO3217" FT /gene_synonym="cdaR" FT /gene_synonym="SCE8.10" FT gene complement(11802..12017) FT /gene="SCO3218" FT /gene_synonym="SCE8.11c" FT CDS complement(11802..12017) FT /product="putative small conserved hypothetical protein" FT /codon_start=1 FT /gene_synonym="SCE8.11c" FT /transl_table=11 FT /note="SCE8.11c, small conserved hypothetical protein, len: FT 71aa; similar to others located within antibiotic synthesis FT clusters egs. TR:O52824 (EMBL:AJ223999) hypothetical FT protein located within the vancomycin biosynthesis cluster FT in Amycolatopsis orientalis (56 aa) fasta scores; opt: 281, FT z-score: 402.6, E(): 4e-15, (67.3% identity in 52 aa FT overlap) and SW:YBDZ_ECOLI hypothetical protein located FT within the enterobactin region of Escherichia coli (72 aa) FT fasta scores; opt: 186, z-score: 272.4, E(): 7.3e-08, FT (32.8% identity in 64 aa overlap)." FT /note="smCOG: SMCOG1009:mbtH-like_protein (Score: 112.4; FT E-value: 1e-34);" FT /db_xref="GI:4490627" FT /db_xref="InterPro:IPR005153" FT /db_xref="InterPro:IPR015166" FT /db_xref="UniProtKB/TrEMBL:Q9Z388" FT /translation="MTNPFEDADGRYLVLVNDEGQHSLWPSFVDVPAGWTVALGESDRE FT ACLEYVEKNWTDMRPRSLVEAMSTGN" FT /gene="SCO3218" FT /protein_id="CAB38589.1" FT gene complement(12140..13315) FT /gene="SCO3219" FT /gene_synonym="SCE8.12c" FT CDS complement(12140..13315) FT /product="putative lipase (putative secreted protein)" FT /codon_start=1 FT /gene_synonym="SCE8.12c" FT /transl_table=11 FT /note="SCE8.12c, possible lipase (putative secreted FT protein), len: 391 aa; weak similarity to many eukaryotic FT lipases e.g. SW:PAFA_CAVPO platelet-activating FT factor-acetylhydrolase from guinea pig (Cavia porcellus) FT (436 aa) fasta scores; opt: 153, z-score: 161.7, E(): 0.11, FT (22.9% identity in 319 aa overlap). Contains PS00120 FT Lipases, serine active site. Contains possible N-terminal FT region signal peptide sequence" FT /db_xref="GI:4490628" FT /db_xref="GOA:Q9Z360" FT /db_xref="InterPro:IPR005065" FT /db_xref="UniProtKB/TrEMBL:Q9Z360" FT /translation="MPNVREAGRPARRCATLVAALLLALVPFGAGAPGTAAARAAPAAD FT AAWTASAVPAPTGALPVGVRTAHLRDTSRRDPWNPDRYRELALSLWYPALPSRAPRASY FT VTARESALILRFHRVEGVPADLLARFRVHARTAPPPLPAPARGLPLVLLSPGFALPRSS FT LTGLAEELASRGYAVAAVDHAYEAPAISHPDGRVTGCLACRRHPEGARVAATRAADLRF FT VRERLLRSPGAVGLPRLDPSRVAVVGHSMGGAAAFEALRTDAGFAAAANLDGTVHTGGR FT SPVDRPFLLLGAGEHGRPGADPTWQRAWRDLSGPRRWLSVRGAGHLSFTDYARLLERTG FT TAGEEVTLGAADAGRVTRELVVAFLDERLRRYGPRLDTAARQDPEVVTHGR" FT /gene="SCO3219" FT /protein_id="CAB38590.1" FT misc_feature complement(12557..12586) FT /note="PS00120 Lipases, serine active site." FT /gene="SCO3219" FT /gene_synonym="SCE8.12c" FT gene complement(13523..13951) FT /gene="SCO3220" FT /gene_synonym="SCE8.13c" FT CDS complement(13523..13951) FT /product="putative secreted protein" FT /codon_start=1 FT /gene_synonym="SCE8.13c" FT /transl_table=11 FT /note="SCE8.13c, putative secreted protein, len: 142 aa; FT contains alanine-rich N-terminal region and possible FT N-terminal region signal peptide sequence" FT /db_xref="GI:4490629" FT /db_xref="UniProtKB/TrEMBL:Q9Z4W4" FT /translation="MRGILRATALTAAIGAVALLPTTAASAAPAGPAASGCVTDSETED FT FGRGEITVCVEDGEVRVTGHVEDLKPGGPFNGGDSGCVGWWIDWETASGPDSSTSTLAC FT PHFTDKPYVEFDYDPTESEYGPKDVTGVADTHLTMVFM" FT /gene="SCO3220" FT /protein_id="CAB38591.1" FT gene complement(14044..14898) FT /gene="SCO3221" FT /gene_synonym="SCE8.14c" FT CDS complement(14044..14898) FT /product="putative oxidoreductase" FT /codon_start=1 FT /gene_synonym="SCE8.14c" FT /transl_table=11 FT /note="SCE8.14c, probable oxidoreductase, len: 284 aa; FT similar to many e.g. TR:O52817 (EMBL:AJ223999) protein FT similar to prephenate dehydrogenase from the vancomycin FT biosynthesis of Amycolatopsis orientalis (367 aa) fasta FT scores; opt: 757, z-score: 865.8, E(): 0, (49.8% identity FT in 283 aa overlap) and SW:TYRA_BACSU prephenate FT dehydrogenase from Bacillus subtilis (372 aa) fasta scores; FT opt: 251, z-score: 291.1, E(): 6.6e-09, (28.3% identity in FT 251 aa overlap)." FT /db_xref="GI:4490630" FT /db_xref="GOA:Q9Z4W3" FT /db_xref="InterPro:IPR003099" FT /db_xref="InterPro:IPR008927" FT /db_xref="InterPro:IPR016040" FT /db_xref="UniProtKB/TrEMBL:Q9Z4W3" FT /translation="MRSVVIVGAGVIGRSVGLALRRHGVTTYLTDADPEAALAGERCGA FT GFAAPPPRQADIAVLAVPPDQVAPVLAEHQKLGTARCYTDVSGVKVRLHREVRAHGCDL FT TSLVSGAPVVGGSGPVQARADLFDGRPWALTPTEATGNLALNCALELVALCGAVSVLLD FT PETHDRAVALVSHAPHLVASLVAARLLGGDESAVRLAGQDLRDVTRTADANPERWARIL FT TANAGPVADQLDDWAAEAQAMARELRDAARSGDTDGPVRLRETLRFGVAGRARIREPHT FT PSS" FT /gene="SCO3221" FT /protein_id="CAB38592.1" FT gene complement(14996..15451) FT /gene="SCO3222" FT /gene_synonym="SCE8.15c" FT CDS complement(14996..15451) FT /product="putative secreted protein" FT /codon_start=1 FT /gene_synonym="SCE8.15c" FT /transl_table=11 FT /note="SCE8.15c, possible small secreted protein, len: 169 FT aa; similar to TR:Q9K3L2 (EMBL:AL360055) Streptomyces FT coelicolor putative secreted protein SCG20A.28c, 150 aa; FT fasta scores: opt: 727 Z-score: 859.9 E(): 2.9e-40; 72.109% FT identity in 147 aa overlap. Contains possible N-terminal FT signal sequence" FT /db_xref="GI:4490631" FT /db_xref="InterPro:IPR015141" FT /db_xref="InterPro:IPR016090" FT /db_xref="PDB:1FAZ" FT /db_xref="UniProtKB/TrEMBL:Q9Z4W2" FT /translation="MRTTTRTRTTLAAVGAALALGVAAAPAQAAPADKPQVLASFTQTS FT ASSQNAWLAANRNQSAWAAYEFDWSTDLCTQAPDNPFGFPFNTACARHDFGYRNYKAAG FT SFDANKSRIDSAFYEDMKRVCTGYTGEKNTACNSTAWTYYQAVKIFG" FT /gene="SCO3222" FT /protein_id="CAB38593.1" FT gene complement(15606..16400) FT /gene="SCO3223" FT /gene_synonym="SCE8.16c" FT CDS complement(15606..16400) FT /product="putative ABC transporter integral membrane FT protein" FT /codon_start=1 FT /gene_synonym="SCE8.16c" FT /transl_table=11 FT /note="SCE8.16c, probable ABC transporter integral membrane FT protein, len: 266aa; located directly downstream of a FT probable ABC transporter ATP-binding protein (6bp gap). FT Similar to many particularly TR:O86630 (EMBL:AL031155) an FT integral membrane protein located directly downstream of a FT probable ABC transporter ATP-binding protein (2bp gap) from FT Streptomyces coelicolor (279 aa) fasta scores; opt: 460, FT z-score: 539.7, E(): 9.4e-23, (37.0% identity in 273 aa FT overlap). Contains several probable membrane spanning FT hydrophobic regions." FT /db_xref="GI:4490632" FT /db_xref="UniProtKB/TrEMBL:Q9Z4W1" FT /translation="MTTTTVPKLVGPVKGGGFKGAVAFEWTKFWSVRATWWNLAVGLLL FT TVAFAAMVGASADASAKKGVDVTMPAPHHASQAFLISQLTIVVLATLALTSEYSSGSIR FT TTLQSVPARGRMLRSKTLVVAAVVVASGFVFSLLGTLVAAPLMGDYGDYSSGQLFGTAL FT GAGVYLALLAVMAIGLGTVLRSAAGTITTLIMVLLALPQLMGVVGAKWLETASDYMPSV FT AGTVLLTQDSDPYGAGTALLVLLLWALAAYAAGTAVLRRRDA" FT /gene="SCO3223" FT /protein_id="CAB38594.1" FT gene complement(16407..17360) FT /gene="SCO3224" FT /gene_synonym="SCE8.17c" FT CDS complement(16407..17360) FT /product="putative ABC transporter ATP-binding protein" FT /codon_start=1 FT /gene_synonym="SCE8.17c" FT /transl_table=11 FT /note="SCE8.17c, probable ABC transporter ATP-binding FT protein, len: 317aa; similar to many egs. TR:O86629 FT (EMBL:AL031155) ABC transporter ATP-binding protein from FT Streptomyces coelicolor (312 aa) fasta scores; opt: 1080, FT z-score: 1174.5, E(): 0, (57.4% identity in 303 aa overlap) FT and SW:BCRA_BACLI bacitracin-resistance ABC transporter FT from Bacillus licheniformis (306 aa) fasta scores; opt: FT 567, z-score: 621.0, E(): 2.8e-27, (42.4% identity in 217 FT aa overlap). N-terminal region previously sequenced FT therefore identical to TR:P72389 (EMBL:U51332) partial, FT designated D7 (103 aa) fasta scores; opt: 666, z-score: FT 734.8, E(): 0, (99.0% identity in 103 aa overlap). Contains FT Pfam match to entry PF00005 ABC_tran, ABC transporter, FT score 151.20, E-value 1.9e-41 and PS00017 ATP/GTP-binding FT site motif A (P-loop)." FT /note="smCOG: SMCOG1000:ABC_transporter_ATP-binding_protein FT (Score: 167.7; E-value: 5.8e-51);" FT /db_xref="GI:4490633" FT /db_xref="GOA:Q9S6T6" FT /db_xref="InterPro:IPR003439" FT /db_xref="InterPro:IPR003593" FT /db_xref="UniProtKB/TrEMBL:Q9S6T6" FT /translation="MITLDRLTKRYGDKTAVSDLSFEINPGKVTGFLGPNGAGKSTTMR FT MIVGLDAPTSGRALVGGKRYEELRHPLREVGALLDARAGHPGRSARHHLLGLARSNGIP FT ASRVGEVLQTVGLSEVANKRIGSFSLGMGQRLGIAAALLGDPKVLLFDEPVNGLDPDGV FT RWVRELMRSLAAEGRTIFVSSHLMSEMQETADHLLVIGRGKIIADAPIEEVIAGSSLTA FT VRVRTPQPDVLRRELLEFGLRVEPNADSAPDELLVVGGTLEEIGDLAFHHRVPIHELSM FT RKASLEQAYMELTAASVEYGSPALSQVTEVPDHQKA" FT /gene="SCO3224" FT /protein_id="CAB38595.1" FT misc_feature complement(16752..17282) FT /note="Pfam match to entry PF00005 ABC_tran, ABC FT transporter, score 151.20, E-value 1.9e-41." FT /gene="SCO3224" FT /gene_synonym="SCE8.17c" FT misc_feature complement(17238..17261) FT /note="PS00017 ATP/GTP-binding site motif A (P-loop)." FT /gene="SCO3224" FT /gene_synonym="SCE8.17c" FT gene 17497..19212 FT /gene="SCO3225" FT /gene_synonym="absA1" FT /gene_synonym="SCE8.18" FT CDS 17497..19212 FT /product="two component sensor kinase" FT /codon_start=1 FT /gene_synonym="absA1" FT /gene_synonym="SCE8.18" FT /transl_table=11 FT /note="SCE8.18, absA1, two component sensor kinase, len: FT 571aa; sequenced previously therefore identical to FT TR:Q53893 (EMBL:U51332) AbsA1, predicted sensor histidine FT kinase which acts as part of a two component signal FT transduction system in the global regulation of antibiotic FT synthesis in Streptomyces coelicolor (571 aa) fasta scores; FT opt: 3782, z-score: 3585.7, E(): 0, (100.0% identity in 571 FT aa overlap)." FT /note="smCOG: SMCOG1048:sensor_histidine_kinase (Score: FT 160.0; E-value: 9.46e-48);" FT /db_xref="GI:4490634" FT /db_xref="GOA:Q53893" FT /db_xref="InterPro:IPR003594" FT /db_xref="InterPro:IPR011712" FT /db_xref="UniProtKB/TrEMBL:Q53893" FT /translation="MHRWQAVRRRIESLVRVLGSERPFTRRADLVLLLVLLVPSAFATG FT TLETAPVAWLTACLLIAAAVVVQRTAPLLSLLLAALLTLFYPWFGANLWPSMATVVLSC FT LAGRRLTRLWPAHLVFLCVAAAGLLLVATVGQGKDWLSLLMTEFVACVLPWWAGNWWSQ FT RTALTHAGWEHAEQLEWRQRYIADQARMKERARIAQDIHDSLGHELSVMALLAGGLELA FT PGLSDPHRESVGQLRERCTMATERLHEVIGLLREDPNPSLTPADESVAQLVRRFQRSGT FT PVRFQEDGARDRPGTPLLSDLAAYRVVQEALTNAAKHAPGAPIDVRVTHTADETVVSVV FT NERPERGGSVPAAGSGSGLIGLDERVRLAGGTLRTGPRAGGFEVYARLPRGASSPSRST FT EPPGPADGDGTAGGSGDGTAPGAATAGNEGRAAAAAADLPAPSGPWRSASRAALLRTRA FT RIRRDARRAALIPAVLGAAIVAFLGGLYVFTSATTSLAPEDYARIRVGETRADLAPALP FT ERRIKKPPPVTSEPSVPAGTTCEYYRASSGLLDFGGAMYRLCFKDDVLMAKDTL" FT /gene="SCO3225" FT /protein_id="CAB38596.1" FT gene 19231..19899 FT /gene="SCO3226" FT /gene_synonym="absA2" FT /gene_synonym="SCE8.19" FT CDS 19231..19899 FT /product="two component system response regulator" FT /codon_start=1 FT /gene_synonym="absA2" FT /gene_synonym="SCE8.19" FT /transl_table=11 FT /note="SCE8.19, absA2, two component system response FT regulator, len: 222aa; sequenced previously therefore FT identical to TR:Q53894 (EMBL:U51332) AbsA2, predicted FT response regulator which acts as part of a two component FT signal transduction system in the global regulation of FT antibiotic synthesis in Streptomyces coelicolor (222 aa) FT fasta scores; opt: 1376, z-score: 1584.1, E(): 0, (100.0% FT identity in 222 aa overlap). Contains Pfam matches to FT entries PF00072 response_reg, Response regulator receiver FT domain, score 138.20, E-value 1.5e-37 and PF00196 GerE, FT Bacterial regulatory proteins, luxR family, score 70.90, FT E-value 2.7e-17. Contains a probable helix-turn-helix motif FT at 171-192aa (Score 1177 (+3.20 SD))." FT /note="smCOG: FT SMCOG1016:LuxR_family_DNA-binding_response_regulator FT (Score: 209.9; E-value: 4.3e-64);" FT /db_xref="GI:4490635" FT /db_xref="GOA:Q53894" FT /db_xref="HSSP:1A04" FT /db_xref="InterPro:IPR000792" FT /db_xref="InterPro:IPR001789" FT /db_xref="InterPro:IPR011006" FT /db_xref="InterPro:IPR011991" FT /db_xref="InterPro:IPR016032" FT /db_xref="UniProtKB/TrEMBL:Q53894" FT /translation="MIRVLLADDETIIRAGVRSILTTEPGIEVVAEASDGREAVELARK FT HRPDVALLDIRMPEMDGLTAAGEMRTTNPDTAVVVLTTFGEDRYIERALDQGVAGFLLK FT ASDPRDLISGVRAVASGGSCLSPLVARRLMTELRRAPSPRSEVSGERTTLLTKREQEVL FT GMLGAGLSNAEIAQRLHLVEGTIKTYVSAIFTQLEVRNRVQAAIIAYEAGLVKDADLNR FT " FT /gene="SCO3226" FT /protein_id="CAB38597.1" FT misc_feature 19234..19575 FT /note="Pfam match to entry PF00072 response_reg, Response FT regulator receiver domain, score 138.20, E-value 1.5e-37." FT /gene="SCO3226" FT /gene_synonym="absA2" FT /gene_synonym="SCE8.19" FT misc_feature 19684..19881 FT /note="Pfam match to entry PF00196 GerE, Bacterial FT regulatory proteins, luxR family, score 70.90, E-value FT 2.7e-17." FT /gene="SCO3226" FT /gene_synonym="absA2" FT /gene_synonym="SCE8.19" FT gene complement(19889..21223) FT /gene="SCO3227" FT /gene_synonym="SCE63.06" FT /gene_synonym="SCE8.20c" FT CDS complement(19889..21223) FT /product="putative aminotransferase" FT /codon_start=1 FT /gene_synonym="SCE63.06" FT /gene_synonym="SCE8.20c" FT /transl_table=11 FT /note="SCE8.20c, partial CDS, possible aminotransferase, FT len: 431 aa; similar to many of undefined function e.g. FT TR:O52815 (EMBL:AJ223998) a protein similar to FT aminotransferase, from a cluster of genes involved in the FT biosynthesis of a vancomycin group antibiotic in FT Amycolatopsis orientalis (Actinomycete) (438 aa) fasta FT scores; opt: 953, z-score: 1093.1, E(): 0, (48.4% identity FT in 426 aa overlap). Also similar to TR:Q64602 (EMBL:Z50144) FT kynurenine/alpha-aminoadipate aminotransferase from rat FT (Rattus norvegicus) kidney (425 aa) fasta scores; opt: 293, FT z-score: 338.4, E(): 1.5e-11, (25.8% identity in 419 aa FT overlap).; SCE63.06, partial CDS, possible FT aminotransferase, len: >45 aa; similar to the N-terminal FT region of TR:O52815 (EMBL:AJ223998) a protein similar to FT aminotransferase from a cluster of genes nvolved in the FT biosynthesis of a vancomycin group antibiotic in FT Amycolatopsis orientalis (Actinomycete) (438 aa) fasta FT scores; opt: 87, z-score: 147.0, E(): 0.69, (45.2% identity FT in 31 aa overlap). The remainder of this CDS lies on the FT neighbouring Streptomyces coelicolor cosmid E8." FT /note="smCOG: SMCOG1019:aminotransferase (Score: 318.7; FT E-value: 8.9e-97);" FT /db_xref="GI:24426511" FT /db_xref="GOA:Q8CJX3" FT /db_xref="InterPro:IPR004839" FT /db_xref="InterPro:IPR015421" FT /db_xref="InterPro:IPR015422" FT /db_xref="InterPro:IPR015424" FT /db_xref="UniProtKB/TrEMBL:Q8CJX3" FT /sec_met="NRPS/PKS subtype: PKS/NRPS-like protein" FT /sec_met="NRPS/PKS Domain: Aminotran_1_2 (86-431). E-value: FT 1.6e-31. Score: 100.9;" FT /translation="MTTTTPARTDRDGVLARTALHPSLSAPLLDTMNFLNEVTLRYPQA FT ISFAPGRPYEGDFDVARVPGYIETYLDHLRGRGHSEERVRTALYQYGETAGQIRDIVAR FT MLEVDEDLTVDPASVVVTVGCQEAVLLTLRALFTGPEDVLLVDSPAYVGITGAAGLLDI FT PVVPVPGTPDGPSPEGLERTVREIEASGRRARCLYVVPDCSNPTGVSLRREARTALLDA FT AARLDLLLLEDNPYGVFSRVRRPTLKSLDTERRVVYLGSFAKTAFPGARVGFVVADQLV FT AGADGRPPGLLAHELAKVKSMVTVNTPTLSQAAVAGLLLQNGGGLRAANEASARHYQST FT MRCLRDTLAAELPPGAPESGGVRWNDPDGGFFLTLDVPFEADEAALDVSAEKYGVIWTP FT MRHFHLDDAGDRQIRLSCSYLTTDRAAEGATRLARFVKDRAASNG" FT /gene="SCO3227" FT /protein_id="CAD55497.1" FT gene complement(21220..22353) FT /gene="SCO3228" FT /gene_synonym="SCE63.05" FT CDS complement(21220..22353) FT /product="putative glycolate oxidase" FT /codon_start=1 FT /gene_synonym="SCE63.05" FT /transl_table=11 FT /note="SCE63.05, probable glycolate oxidase, len: 377 aa; FT similar to many both prokaryotic and eukaryotic e.g. FT TR:O52792 (EMBL:AJ223998) similar to glycolate oxidase from FT a cluster of genes nvolved in the biosynthesis of a FT vancomycin group antibiotic in Amycolatopsis orientalis FT (Actinomycete) (357 aa) fasta scores; opt: 995, z-score: FT 998.4, E(): 0, (47.5% identity in 343 aa overlap) and FT SW:GOX_SPIOL glycolate oxidase from Spinacia oleracea FT (spinach) (369 aa) fasta scores; opt: 917, z-score: 920.7, FT E(): 0, (41.9% identity in 360 aa overlap). Contains Pfam FT match to entry PF01070 FMN_dh, FMN-dependent de FT hydrogenase, score 412.60, E-value 3.6e-120 and PS00557 FT FMN-dependent alpha-hydroxy acid dehydrogenases active FT site." FT /db_xref="GI:4481936" FT /db_xref="GOA:Q9Z4X8" FT /db_xref="HSSP:1GOX" FT /db_xref="InterPro:IPR000262" FT /db_xref="InterPro:IPR008259" FT /db_xref="InterPro:IPR012133" FT /db_xref="InterPro:IPR013785" FT /db_xref="UniProtKB/TrEMBL:Q9Z4X8" FT /translation="MREPLTLDDFARLARGQLPAATWDFIAGGAGRERTLAANEAVFGA FT VRLRPRALPGIEEPDTSVEVLGSRWPAPVGIAPVAYHGLAHPDGEPATAAAAGALGLPL FT VVSTFAGRSLEEVARAASAPLWLQLYCFRDHETTLGLARRARDSGYQALVLTVDTPFTG FT RRLRDLRNGFAVPAHITPANLTGTAAAGSATPGAHSRLAFDRRLDWSFVARLGAASGLP FT VLAKGVLTAPDAEAAVAAGVAGIVVSNHGGRQLDGAPATLEALPEVVSAVRGRCPVLLD FT GGVRTGADVLAALALGARAVLVGRPALYALAVGGASGVRRMLTLLTEDFADTMVLTGHA FT ATGTIGPDTLAPPHHAPPHHGPPTAPRPAPHRDRSHG" FT /gene="SCO3228" FT /protein_id="CAB38520.1" FT misc_feature complement(21298..22314) FT /note="Pfam match to entry PF01070 FMN_dh, FMN-dependent de FT hydrogenase, score 412.60, E-value 3.6e-120" FT /gene="SCO3228" FT /gene_synonym="SCE63.05" FT misc_feature complement(21592..21612) FT /note="PS00557 FMN-dependent alpha-hydroxy acid dehydrogena FT ses active site." FT /gene="SCO3228" FT /gene_synonym="SCE63.05" FT gene complement(22503..23618) FT /gene="SCO3229" FT /gene_synonym="SCE63.04" FT CDS complement(22503..23618) FT /product="putative 4-hydroxyphenylpyruvic acid dioxygenase" FT /codon_start=1 FT /gene_synonym="SCE63.04" FT /transl_table=11 FT /note="SCE63.04, probable 4-hydroxyphenylpyruvic acid FT dioxygenase, len: 371 aa; similar to many both prokaryotic FT and eukaryotic e.g. TR:O52791 (EMBL:AJ223998) similar to FT hydroxyphenyl pyruvate dioxygenase from a cluster of genes FT involved in the biosynthesis of a vancomycin group FT antibiotic in Amycolatopsis orientalis (Actinomycete) (357 FT aa) fasta scores; opt: 989, z-score: 1130.3, E(): 0, (48.7% FT identity in 355 aa overlap) and SW:HPPD_MOUSE hpd, FT 4-hydroxyphenylpyruvic acid dioxygenase from Mus musculus FT (mouse) (392 aa) fasta scores; opt: 610, z-score: 698.5, FT E(): 1.3e-31, (31.6% identity in 361 aa overlap)." FT /db_xref="GI:4481935" FT /db_xref="GOA:Q9Z4X7" FT /db_xref="InterPro:IPR004360" FT /db_xref="InterPro:IPR005956" FT /db_xref="UniProtKB/TrEMBL:Q9Z4X7" FT /translation="MLPPFPFLHWRAAMPPSDIAYAELYVADDREASGFLVDSLGFVPL FT AVAGPATGTHDRRSTVLRSGEVTLVVTQALAPDTPVARYVERHGDSIADLAFGCDDVRS FT CFDRAVLAGAEALQAPTPSHRAGQDAWFATVSGFGDIRHTLVPAADGDGAGLLPPDRDW FT ALLPAATGRTGPRPLLDHVAVCLESGTLRSTAEFYEAAFDMPYYSSEYIEVGEQAMDSI FT VVRNAGGGITFTLIEPDDTRVPGQIDQFLSAHDGPGVQHLAFLVDDIVGSVRSLGDRGV FT AFLRTPGAYYDLLTERVGAMADAIEDLRETNVLADRDEWGYLLQIFTRSPYPRGTLFYE FT YIQRNGARGFGSSNIKALYEAVEREREVAGR" FT /gene="SCO3229" FT /protein_id="CAB38519.1" FT gene 23887..46278 FT /gene="SCO3230" FT /gene_synonym="cdaPSI" FT /gene_synonym="SCE63.03c" FT CDS 23887..46278 FT /product="CDA peptide synthetase I" FT /codon_start=1 FT /gene_synonym="cdaPSI" FT /gene_synonym="SCE63.03c" FT /transl_table=11 FT /note="SCE63.03c, cdaPSI, CDA peptide synthetase I, len: FT 7463 aa; part of the calcium-dependent antibiotic (CDA) FT biosynthetic cluster from Streptomyces coelicolor. CDA is a FT peptide antibiotic which is synthesised non-ribosomally by FT a putative multifunctional peptide synthetase enzyme. This FT CDS encodes a subunit of this enzyme and is suspected to be FT responsible for the incorperation of the first 6 amino FT acids into the antibiotic structure. This ORF overlaps the FT downstream (cdaPSII) ORF by one base indicating possible FT translational coupling. Contains eight separate Pfam FT matches to entry PF00668 DUF4, Domain of unknown function FT (U), six separate Pfam matches to entry PF00501 FT AMP-binding, AMP-binding enzyme (A) and six separate Pfam FT matches to entry PF00550 pp-binding, Phosphopantetheine FT attachment site (P). These Pfam matches cover the full FT length of the protein in the following order from N to FT C-terminal U-A-P-U-A-P-U-A-P-U-U-A-P-U-A-P-U-A-P-U." FT /note="smCOG: FT SMCOG1127:condensation_domain-containing_protein (Score: FT 278.0; E-value: 1.824e-83);" FT /db_xref="GI:4481934" FT /db_xref="GOA:Q9Z4X6" FT /db_xref="HSSP:1AMU" FT /db_xref="InterPro:IPR000873" FT /db_xref="InterPro:IPR001242" FT /db_xref="InterPro:IPR006162" FT /db_xref="InterPro:IPR006163" FT /db_xref="InterPro:IPR009081" FT /db_xref="InterPro:IPR010060" FT /db_xref="InterPro:IPR010071" FT /db_xref="InterPro:IPR020806" FT /db_xref="InterPro:IPR020845" FT /db_xref="UniProtKB/TrEMBL:Q9Z4X6" FT /sec_met="Type: nrps" FT /sec_met="Domains detected: Condensation (E-value: 7.4e-37, FT bitscore: 118.3, seeds: 42); Condensation (E-value: FT 3.1e-67, bitscore: 218.1, seeds: 42); Condensation FT (E-value: 1.2e-68, bitscore: 222.7, seeds: 42); FT Condensation (E-value: 2.8e-44, bitscore: 142.7, seeds: FT 42); Condensation (E-value: 1.4e-63, bitscore: 206.1, FT seeds: 42); Condensation (E-value: 7e-72, bitscore: 233.3, FT seeds: 42); Condensation (E-value: 3.5e-71, bitscore: FT 231.0, seeds: 42); Condensation (E-value: 2.2e-34, FT bitscore: 110.2, seeds: 42); AMP-binding (E-value: FT 9.6e-127, bitscore: 414.3, seeds: 400); AMP-binding FT (E-value: 6.4e-126, bitscore: 411.5, seeds: 400); FT AMP-binding (E-value: 1.7e-111, bitscore: 364.0, seeds: FT 400); AMP-binding (E-value: 4.6e-101, bitscore: 329.7, FT seeds: 400); AMP-binding (E-value: 8.8e-103, bitscore: FT 335.3, seeds: 400); AMP-binding (E-value: 4.3e-116, FT bitscore: 379.2, seeds: 400); PP-binding (E-value: 4.5e-16, FT bitscore: 50.6, seeds: 164); PP-binding (E-value: 9e-18, FT bitscore: 56.0, seeds: 164); PP-binding (E-value: 3.4e-13, FT bitscore: 41.4, seeds: 164); PP-binding (E-value: 3.3e-17, FT bitscore: 54.2, seeds: 164); PP-binding (E-value: 6.5e-17, FT bitscore: 53.3, seeds: 164); PP-binding (E-value: 1.7e-13, FT bitscore: 42.4, seeds: 164)" FT /sec_met="Kind: biosynthetic" FT /sec_met="NRPS/PKS subtype: NRPS" FT /sec_met="NRPS/PKS Domain: Condensation_Starter (7-318). FT E-value: 1.6e-103. Score: 337.4;" FT /sec_met="NRPS/PKS Domain: AMP-binding (496-907). E-value: FT 8.9e-127. Score: 414.3;" FT /sec_met="NRPS/PKS Domain: PCP (1092-1160). E-value: FT 5.3e-27. Score: 85.1;" FT /sec_met="NRPS/PKS Domain: Condensation_LCL (1174-1480). FT E-value: 4.1e-114. Score: 371.9;" FT /sec_met="NRPS/PKS Domain: AMP-binding (1695-2121). FT E-value: 5.9e-126. Score: 411.5;" FT /sec_met="NRPS/PKS Domain: PCP (2202-2270). E-value: FT 1.5e-27. Score: 86.9;" FT /sec_met="NRPS/PKS Domain: Condensation_LCL (2284-2585). FT E-value: 1.5e-116. Score: 379.8;" FT /sec_met="NRPS/PKS Domain: AMP-binding (2784-3184). FT E-value: 1.6e-111. Score: 364.0;" FT /sec_met="NRPS/PKS Domain: PCP (3267-3333). E-value: FT 5.6e-20. Score: 62.6;" FT /sec_met="NRPS/PKS Domain: Epimerization (3349-3651). FT E-value: 3.3e-133. Score: 436.3;" FT /sec_met="NRPS/PKS Domain: Condensation_DCL (3824-4122). FT E-value: 5.1e-114. Score: 371.7;" FT /sec_met="NRPS/PKS Domain: AMP-binding (4303-4681). FT E-value: 4.3e-101. Score: 329.7;" FT /sec_met="NRPS/PKS Domain: PCP (4764-4833). E-value: FT 8.5e-29. Score: 90.9;" FT /sec_met="NRPS/PKS Domain: Condensation_LCL (4846-5147). FT E-value: 3.9e-118. Score: 385.1;" FT /sec_met="NRPS/PKS Domain: AMP-binding (5343-5721). FT E-value: 8.1e-103. Score: 335.3;" FT /sec_met="NRPS/PKS Domain: PCP (5804-5871). E-value: FT 6.6e-27. Score: 84.8;" FT /sec_met="NRPS/PKS Domain: Condensation_LCL (5886-6187). FT E-value: 7.4e-119. Score: 387.4;" FT /sec_met="NRPS/PKS Domain: AMP-binding (6381-6801). FT E-value: 3.9e-116. Score: 379.2;" FT /sec_met="NRPS/PKS Domain: PCP (6886-6953). E-value: FT 1.3e-23. Score: 74.3;" FT /sec_met="NRPS/PKS Domain: Epimerization (6969-7279). FT E-value: 3.3e-113. Score: 370.2;" FT /translation="MSENSSVRHGLTSAQHEVWLAQQLDPRGAHYRTGSCLEIDGPLDH FT AVLSRALRLTVAGTETLCSRFLTDEEGRPYRAYCPPAPEGSAAVEDPDGVPYTPVLLRH FT IDLSGHEDPEGEAQRWMDRDRATPLPLDRPGLSSHALFTLGGGRHLYYLGVHHIVIDGT FT SMALFYERLAEVYRALRDGRAVPAAAFGDTDRMVAGEEAYRASARYERDRAYWTGLFTD FT RPEPVSLTGRGGGRALAPTVRSLGLPPERTEVLGRAAEATGAHWARVVIAGVAAFLHRT FT TGARDVVVSVPVTGRYGANARITPGMVSNRLPLRLAVRPGESFARVVETVSEAMSGLLA FT HSRFRGEDLDRELGGAGVSGPTVNVMPYIRPVDFGGPVGLMRSISSGPTTDLNIVLTGT FT PESGLRVDFEGNPQVYGGQDLTVLQERFVRFLAELAADPAATVDEVALLTPDERERVLD FT GWNDTAHEVPETTLPELFAARAARTPGHEALVYEGTSLTYAELDARAERLAGALTARGA FT GPERFVAVAVERSAELVVALLAVLKSGAAYVPVDPGYPADRIAHILRDAGAMLVLTTRD FT TAERLPGDGTPRLLLDEPAAAGTTAAGAPAPPGTLPRALPAPGHPAYVIYTSGSTGRPK FT GVVISHRAIVNRLAWMQDTYGLEPSDRVLQKTPSGFDVSVWEFFWPLVQGATLVVARPG FT GHTDPAYLAGTVRREGVTTLHFVPSMLDVFLREPAAAALGGATPVRRVFCSGEALPAEL FT RARFRAVSDVPLHNLYGPTEAAVDVTYWPCAEDTGDGPVPIGRPVWNTRMYVLDAALRP FT VPAGVPGELYIAGVQLARGYLGRPALSAERFTADPHGAPGSRMYRTGDLARWNHDGSLD FT YLGRADHQVKLRGFRIELGEIEAALVRQPEIAQAAVVLREDRPGDQRLVAYTVPARDAD FT TLTGPPAEAGTHPGPGAAPDTDPATGPAAGTDSGPGSGTGSGTGSGTGSGARPGPDGTA FT THTVAGAGPAAAGETAAGADAGTGTGETGAGADAGTGTGAHAGPDGAVLAARLRELLPG FT YMVPSAFVALPRLPVTPNGKLDRRALPAPAESGRAAGRAPRTPGEELLCALFAEVLGVA FT EVRVDDGFFDLGGHSLLATRLISRIRATAGAEVPIRRVFEAPTVAELAPALTDGGRARA FT AVTARPRPDRLPLSFAQRRLWFIHQYEGPSPLYNIPAALRLTGPVDGAALSAALGDVVA FT RHESLRTVFAEDAHGPHQVILSAERAAPRLKTLDSDPERLAADLARTARHTFDLTRDVP FT LRATLLRVAPEEHVLLLVLHHIAGDGWSLAPLARDLGTAYAARTAGTAPDWAPLPVQYA FT DYTLWQRELLGADGNGAGTGDGGEGARQLAHWREALAGLPERLELPSDRPRPARRDNSG FT ARLDVSVPAGLHRSLAALAAETRTSVFMVLQAALAGLLTRLGAGEDVPIGSTIAGRTDA FT AVENLVGFFVNTLVLRTDTGGDPAFRELLSRVRERDLAAYAHQDVPFERLVEAVNPDRA FT TSHHPLFQVMLTFDTTQQDALGELGRLPGITTSLLPVHTGLSRFDLVFAFDERRDAAGG FT QAGLDLAVEFSTELFDAGTVRALTERLLLLLTQVAADPGVRLGDLDVLLPGEHHDLLVA FT ANRPGTAPASPAPASPEPASPEPASPAPGTATLPELFERQAARHPDRTALTFEGTSLSY FT AELNARANRLARLLTARGIGPDALVALALPRSAELVVALLAVVKSGAAYVPLDPGYPAD FT RLAHALSDSAPAALLTDRATAGRLPAHEVPRIVLDAPAPADGGTTGGDPADAHPATDLA FT QGERVRPLDPRDTAYVIYTSGSTGRPKGVAVPHGNVVRLFSATAPWFGFDEHDVWTLFH FT SYAFDFSVWELWGPLLHGGRLVVVPHDVTRDPAAFLALLARERVTVLNQTPSAFHQLAA FT ADRENPTELALRTVVFGGEALDLSRLADWYERHAEDAPALVNMYGITETTVHVSHFALD FT RATAAASSASTIGVNIPDLRVYVLDDRLRPTAPGVTGEMYVAGAGLARGYLGRPALTAD FT RFPADPYAALFGERGTRMYRTGDLARRRTDGGLDYLGRADQQVKIRGFRIEPGEIEAVL FT AAHPAVDDVAVVAREDVQGDPRLVAYVVTGSGATARALHDHAAGHLPDHMLPSAFVTLD FT VLPLTPNGKLDTKALPAPAHAGQVTGRAPRGPREEILCALFAEVLGVPRLTVDDSFFDL FT GGHSLLATRLAGRIRGTLGVELSVRRLFETPTVAGLSAALDGAERSGTGPTAGERPERL FT PLSYAQQRLWFLHQLEGPSPTYNITGALRLTGDLDPGALRAAFQDVVTRHESLRTVFSE FT DGHGARQTVLDAAGVRFELPVADVSEDRLDARLEEAARHCFDLTTDIPVRAELFRLGAR FT EHVLLLMVHHIAGDGWSLGPLIRDLAAAYTARAARRAPDWAPLPVQYADFALWQRAALG FT DAADATSPAGRQLAHWKEALAGLPDRLELPADRPLPAVASHRGGRVPLTVPAPLHSGVA FT ELARESRTSVFMVLQAALAALLTRMGAGEDVPLGTPVAGRGDDAVDQVVGFFVNTLVLR FT TDTGGNPTFRALLDRVRDTDLTAYDHQDLPFEHLVDVLSPTRSLSHNPLFQVLLSLDTT FT QQDALAALSATGLGVRLLNVTTGVAKLDLALEIAEHRDADGAPAGLVGAAEYSADLFDE FT GTVTLLVERFLRLLDALVADPSRRIGDVDVLGPRERERVLTEWNDTPRRPVQGTFADHV FT ARHAAERPGHLAVETAGAAAPGGALTYGELNERANRLARALLARGAGPERFVAVALPRS FT ADLVLSALAAFKAGAAYLPVDPAHPAERITHLVSDAAPTLIVTTSALAASLPDTGTPVL FT LLDTPETAATLAALPGHDVTDADRPVPLRPEHPAYMIYTSGTTGRPKGVVVTHTGLPGL FT LDIFTRDCAAGPGSRILQHLSPSFDASFWELAMGLLTGATLVVAPPETTPGPELAELAT FT RHAATHLSLTTSVLGLLPPDSLPDGLTLVVGAEAIPPELVERWSPGRTMLNSYGPTETT FT VCSTMSGPLSGPAVPPIGSPVANSAVYVLDAALRPVPPGVPGELYAAGAHLARGYHDRR FT ALTAERFVANPFGEPGSRLYRTGDLVRWRPDGQLEYLGRADTQVKIRGLRIEPTEIEAV FT ITERPHLARAAVIVREDRPGDRRLVAYVVPEPGATVDTAELRAALRETLPDHMIPTAFV FT VLDALPLTLNGKLDRKALPAPDYSARTSGRAARDPRERLLTALFGEILGVEPAGVDDGF FT FDLGGDSILSIQLVARARAAGLVLSVRDVFEHQTPALLARSAAAAPAGDRTARDSDVPA FT DGPAPRTPMMGWFAALGSDLAAFNQSLVLRVPAALDPDTLDTALRAVLDRHDALRMRVA FT DDWTIEIPPPGSVTPADCLVRFDAVGLDEAAVRSAVTEQARTARDRLAPADGRMLQAVW FT LDRGADRDGLLLLVANHLVVDGVTWRILVPDLAAAYAGETLAPVGTPWRHWALSLSDLA FT GQPRTEEELDHWHSVLGDTPHTLRLDPARDTHATAGEITAELDADTTEALLTWVPGVCH FT ATVNDVFLSTFALAVAGWRRGRGEDADAPVVLDLESHGRHEEAVPGVELSRTAGWFTSM FT YPVRLAPPAGASGDGSALRALKAVKEQLRTVPGDGLGYGLLRHLNPRTRAALAALPLPE FT FGFNYLGRIGQEGTDEAPWTIEGGDVAGIDGAMPLAHPVDVNAVARETADGTRLRARWT FT YSRTALEPEDTQRLADTWFRLLRRLVEEARQPGAGGLTPSDIAHPALAQDEIEDLEHTV FT PGLQDILPLAPLQEGFLFLNLYDENARDVYVGQLAFDLEGSFDGTRMRAAAGALLRRHA FT NLRAGFRQTATGTWVQVVPAELEPDWRECDLTDRADEAERDAEAGRLAAGDRERRFDLT FT SPPLMRFTAIRLSADRVRLVMTNHHILLDGWSMPLLWQELTELYVSGGDPVSLPPVRPY FT RDHLAWLGARDRDAARDAWRRSLSGLDEATLLAPDAGPAEAAPLGIPFGLDRDATAALS FT AWARGRGVTMNTVVQGAWALALAQATGRDDVVFGATVSGRPPELPGVESMIGLFINTLP FT VRARLDQAEPLGDLFRRLQNEQARLLDHQWPGLADIQHWAGHGELFDTAMVFQNYPVSA FT DTTSRQLDGLRVAGYDAVESTDFAVNLVAHTRDDALRLRLDYRADACAGDLVRSLADRM FT LRVLEALVTDSDRPVAHLDTLDPAVRERVLVEWNGAPTQLPGTPLHELISEQARLTPDA FT VAVVCDGTSLTYAELDGGANQLARHLLGEGLGAEDFVAIALAKSLDAVISMLAVLKTGA FT AYLPIDPDYPAERITYMLDDARPALTLTEPVPVERYTGHSVTAVTDEERRSPWSARHAA FT YMIYTSGSTGRPKGVVIEHHALATYLHRARNTYTAMTGVTVLHSPLAFDLTITALWTPL FT TSGGTVHLTSLEESDTQPSLIKATPSHLPLLTTLPETASPSHTLILGGEALHTDHLVTW FT RTQHPGVQIINAYGPTESTVNITDHHVGEDTPDGPVPIGRPFANTQVYVLDSALRPVAP FT GVTGELYLAGEQLARGYLGRPALTAERFTANPHSSTPGARMYRTGDLAHWNHHGHLTYD FT GRADHQIKLRGHRIEPGEIEATLTAQTGITQATVQLREDQPGDQRLVAYLVVNDSTEYD FT EKTVRDALTSALPDYMVPSALVTLDALPLTPNGKLDRTALPAPAYSASTAGRAPRTPRE FT EVLCTLFAEVLGVDLVTIDDNFFDLGGHSLLATRLVSRTRTALGVELSIRQLFETPTVA FT GLAEALDASGTVRTALTARPRPERIPLSYAQQRLWFLHQLEGPSATYNTVLTLRLGGAL FT DVDALRAAISDVVARHESLRTVFTEDERGAYQIVLPVEAASTPFTVVDVAEEEIGDRLD FT EAVGHCFDLAQELPARTSLFRVSEREHVLLLLIHHIASDAWSRAPLAQDLTAAYAARVR FT SEAPMWAPLTVQYADYALWQQEILGDDTDADSLAGRQLAYWKQQLAGLPEQLDLPTDRP FT RPAVAGYSGDRVPFTVPTELHTRLTELARATNTSAFMVIQAAVAVLLTRLGAGEDIPIG FT TPVAGRTDDAADDLIGLFINTLVLRTDTSGDPTFRRLLDRVRDTDLAAYAHQDLPFERL FT VEALNPARTLSHHPLFQVLLTFNNTDHEGALKDISELPGLTVALREVQRTSSKFDLSFG FT FAESFDTSRRPQGIEAALDFSTELLDRRSAQAIADRFLRVLEAVTTAPDRPIGAVELMD FT PAERERVLVEWNGAPTQLPGTPLHELISEQARLTPDAVAVVCDGTTLTYAELDRRANQL FT ARHLLGEGLGAEDFVAIALAKSLDAVISMLAVLKTGAAYLPIDPDYPAERITYMLDDAQ FT PALTLTAPIPPASYDSRPTSEITDVERRSPWSARHAAYMIYTSGSTGRPKGVVIEHHAL FT ATYLHRARNTYTAMTGVTVLHSPLAFDLTITALWTPLTAGGTVHLTSLEEAEVQPSLIK FT ATPSHLPLLTTLPETASPSHTLILGGEALHTDHLATWRTQHPGAQIINAYGPTESTVNI FT TDHHVSEDTPDGPVPIGRPFANTQVYVLDSALRPVAPGVTGELYLAGEQLARGYLGRPA FT LTAERFTANPHSSTPGARMYRTGDLAHWNHDGHLTYDGRADHQIKLRGHRIEPGEIETT FT LTAQTGITQTTVQLREDTPGDQRLVAYLVVNDSTEYDEPTLRDALASALPDYMRPSAYV FT TLDALPLTPNGKLDRTALPAPAYSASTTGRTPRTPREEILCTLFAEVLGVDLVTIDDNF FT FDLGGHSLLATRLVSRARTALGVELSVRQFFETPTIAGLSGAFDRAGRARAALTARPRP FT ERIPLSYAQQRLWFLHQLEGPSATYNIPTTLRLTGTLDTDALQSALNDLLARHESLRTT FT YTEDGEGPRQVIHAWEPGMLPLGVVDTGEGELDAMLSAGVHHAFDLTAGIPVRATLFRI FT SEQEHVLLLLIHHIATDAWSRTPLGHDLAAAYSARCAGDVPAWEPLPVQYADYALWQRE FT VLGDEGDADAPAGRQLAYWTRQLADLPEQLDLPTDRPRPAVASQDGDRVAFSLDADLYV FT RLTELARATHSSTFMVVQAALAVLLTRLGAGEDIPIGTPVAGRTDDATENLVGFFVNTL FT VLRNDTSGNPTFRELLEETRRTDLAAYAHQDLPFERLVEALNPARTLAHHPLFQVMLIL FT STAETDPDASLALPGLRVGAERSRLGAAKVDLAFALAEVRDGEGRSTGLTGALDFRTDL FT FDRSTARSLVERFVRTLEAVVADPGVRLSRVPVLTGSERRSLLDRGTGPLLEGLDATLP FT ELFAEQALRTPGAPALVRGGTTVSYAELDLRTNRLARLLRQQGVRPGTPVVMLMERSPA FT HVVATLAIAKAGGAYVPLHDTYPLDRMRHVVADTAATLILTDRAEAARAGQLGARVMVV FT DEFGAAPSGSEADAAPGTGTGTGTGSRSGYVDDAPEVGLRPQDLAYVMYTSGSTGVPKG FT VAVTHRGVVDLVRDHCWRPGVHERVLLHAPHAFDVSCYEMWVPLVSGGTVVVAPPGHLD FT PAAITDLITAHDITAIHLTAGFFRVVAEEAPECFAGVREVLTGGDVVSPAAVARVLAHH FT PRIVLRHLYGPTETTLCVTQHEVTAPYEARGSLPVGRATGNTRAYVLDRYLQPVPAGVP FT GELFISGSGLARGYLDRPDLTCERFVADPYGGSGERMYRTGDLVRYNAAGELEYLARAD FT DQVKIRGFRVELGEIEAVLATRPELAQAAVVVREDRPGDRRLVGYVVAAAGRDGEVDPD FT ALRAFSRQALPDYMVPSAFVVLGTLPLTANGKLDRKALPAPDYGAASTGRAARTPAEEL FT LCTLFAQVLGLSAVGVDDGFFDLGGDSILSIQLVSRARAAGLALAVRDVFEHQSTARLA FT AALTDRDDAASVPEAEAVPPYGPAPLTPVMARIAELGLGGDDFNQSVVVSLPPAVDRDR FT LVPALQRVLDHHDALRLRVLPDGSTEVRAPGSVPAADVLSVVTRAPGATGEARDALLVE FT AACAARDRLAPAEGRMLQAVLVDGTDDTDGTGGTSGADGVLILVAHHLVVDSVTWSIVV FT PDLAAAYRGEEPAPVGTSWRQWATSLARLATDPRVEAETAHWEHTLTGAGTLRLDRGRD FT LQGDAGRISLDLAPHTTEALLTRLPGGVNASVHDVLLTAFAFAVAGWRRGRGEDPDAPV FT VLDLESHGRHEEAVPGAELSRTAGWFTALHPVRLAPDVTDWARLHQDGDALRDGLKQVK FT EQLRSVPGDGLGHGLLRHLNPTAGPRLARLPEPDFGFNYLGRRVTPATGTPEPWTVTGG FT GLAASRPTAPMAHAVELSAVVHEGADGPRLRAEWTYARRLVPDHDARRLAEQWFRALEA FT LVEQADRAGTGGLTPSDVTLGSLSQSEIEEFESDLESEWEIEQ" FT /gene="SCO3230" FT /protein_id="CAB38518.1" FT misc_feature 23899..25089 FT /note="Pfam match to entry PF00668 DUF4, Domain of unknown FT function, score 80.00, E-value 5e-20" FT /gene="SCO3230" FT /gene_synonym="cdaPSI" FT /gene_synonym="SCE63.03c" FT CDS_motif 23914..23952 FT /note="NRPS/PKS Motif: C1_starter_004-017 (e-value: 0.03, FT bit-score: 7.6);" FT CDS_motif 23974..24087 FT /note="NRPS/PKS Motif: C2_starter_024-063 (e-value: FT 8.9e-13, bit-score: 40.8);" FT misc_feature 24295..24327 FT /note="PS00639 Eukaryotic thiol (cysteine) proteases FT histidine active site." FT /gene="SCO3230" FT /gene_synonym="cdaPSI" FT /gene_synonym="SCE63.03c" FT CDS_motif 24349..24414 FT /note="NRPS/PKS Motif: C3_starter_134-155 (e-value: FT 2.9e-08, bit-score: 26.6);" FT CDS_motif 24742..24831 FT /note="NRPS/PKS Motif: C5_starter_265-294 (e-value: FT 9.7e-12, bit-score: 37.2);" FT CDS_motif 24883..24981 FT /note="NRPS/PKS Motif: C67_starter_14fromHMM (e-value: FT 9.7e-08, bit-score: 24.6);" FT misc_feature 25375..26607 FT /note="Pfam match to entry PF00501 AMP-binding, AMP-binding FT enzyme, score 601.30, E-value 5.6e-177" FT /gene="SCO3230" FT /gene_synonym="cdaPSI" FT /gene_synonym="SCE63.03c" FT CDS_motif 25498..25539 FT /note="NRPS/PKS Motif: NRPS-A_a2 (e-value: 0.0001, FT bit-score: 15.6);" FT CDS_motif 25750..25809 FT /note="NRPS/PKS Motif: NRPS-A_a3 (e-value: 2.6e-10, FT bit-score: 32.1);" FT misc_feature 25756..25791 FT /note="PS00455 Putative AMP-binding domain signature." FT /gene="SCO3230" FT /gene_synonym="cdaPSI" FT /gene_synonym="SCE63.03c" FT CDS_motif 26191..26214 FT /note="NRPS/PKS Motif: NRPS-A_a5 (e-value: 1.7, bit-score: FT 2.4);" FT CDS_motif 26326..26415 FT /note="NRPS/PKS Motif: NRPS-A_a6 (e-value: 5.9e-16, FT bit-score: 50.5);" FT CDS_motif 26500..26565 FT /note="NRPS/PKS Motif: NRPS-A_a8 (e-value: 9.3e-12, FT bit-score: 36.9);" FT CDS_motif 27085..27111 FT /note="NRPS/PKS Motif: NRPS-A_a10 (e-value: 0.84, FT bit-score: 3.2);" FT misc_feature 27166..27360 FT /note="Pfam match to entry PF00550 pp-binding, Phosphopante FT theine attachment site, score 74.30, E-value 6.3e-19" FT /gene="SCO3230" FT /gene_synonym="cdaPSI" FT /gene_synonym="SCE63.03c" FT CDS_motif 27169..27201 FT /note="NRPS/PKS Motif: Cy4 (e-value: 0.09, bit-score: FT 6.1);" FT misc_feature 27235..27282 FT /note="PS00012 Phosphopantetheine attachment site." FT /gene="SCO3230" FT /gene_synonym="cdaPSI" FT /gene_synonym="SCE63.03c" FT misc_feature 27403..28605 FT /note="Pfam match to entry PF00668 DUF4, Domain of unknown FT function, score 318.40, E-value 8.5e-92" FT /gene="SCO3230" FT /gene_synonym="cdaPSI" FT /gene_synonym="SCE63.03c" FT CDS_motif 27424..27456 FT /note="NRPS/PKS Motif: C1_LCL_004-017 (e-value: 0.046, FT bit-score: 6.9);" FT CDS_motif 27475..27591 FT /note="NRPS/PKS Motif: C2_LCL_024-062 (e-value: 1.1e-18, FT bit-score: 59.6);" FT CDS_motif 27793..27858 FT /note="NRPS/PKS Motif: C3_LCL_132-143 (e-value: 4.4e-09, FT bit-score: 28.8);" FT CDS_motif 27907..27945 FT /note="NRPS/PKS Motif: C4_LCL_164-176 (e-value: 0.0001, FT bit-score: 14.9);" FT CDS_motif 28228..28317 FT /note="NRPS/PKS Motif: C5_LCL_267-296 (e-value: 1.3e-14, FT bit-score: 46.5);" FT CDS_motif 28366..28485 FT /note="NRPS/PKS Motif: C67_LCL_14fromHMM (e-value: 3.3e-22, FT bit-score: 70.9);" FT misc_feature 28972..30249 FT /note="Pfam match to entry PF00501 AMP-binding, AMP-binding FT enzyme, score 563.60, E-value 1.2e-165" FT /gene="SCO3230" FT /gene_synonym="cdaPSI" FT /gene_synonym="SCE63.03c" FT CDS_motif 29095..29136 FT /note="NRPS/PKS Motif: NRPS-A_a2 (e-value: 0.00021, FT bit-score: 14.7);" FT CDS_motif 29371..29430 FT /note="NRPS/PKS Motif: NRPS-A_a3 (e-value: 9.8e-10, FT bit-score: 30.4);" FT misc_feature 29377..29412 FT /note="PS00455 Putative AMP-binding domain signature." FT /gene="SCO3230" FT /gene_synonym="cdaPSI" FT /gene_synonym="SCE63.03c" FT CDS_motif 29815..29838 FT /note="NRPS/PKS Motif: NRPS-A_a5 (e-value: 8.8, bit-score: FT 0.5);" FT CDS_motif 29959..30045 FT /note="NRPS/PKS Motif: NRPS-A_a6 (e-value: 4.3e-15, FT bit-score: 47.8);" FT CDS_motif 30142..30207 FT /note="NRPS/PKS Motif: NRPS-A_a8 (e-value: 6.1e-12, FT bit-score: 37.4);" FT CDS_motif 30415..30441 FT /note="NRPS/PKS Motif: NRPS-A_a10 (e-value: 18.0, FT bit-score: -0.2);" FT misc_feature 30496..30690 FT /note="Pfam match to entry PF00550 pp-binding, Phosphopante FT theine attachment site, score 82.80, E-value 2.8e-21" FT /gene="SCO3230" FT /gene_synonym="cdaPSI" FT /gene_synonym="SCE63.03c" FT CDS_motif 30499..30531 FT /note="NRPS/PKS Motif: Cy4 (e-value: 0.17, bit-score: FT 5.2);" FT misc_feature 30565..30612 FT /note="PS00012 Phosphopantetheine attachment site." FT /gene="SCO3230" FT /gene_synonym="cdaPSI" FT /gene_synonym="SCE63.03c" FT misc_feature 30733..31917 FT /note="Pfam match to entry PF00668 DUF4, Domain of unknown FT function, score 302.10, E-value 6.9e-87" FT /gene="SCO3230" FT /gene_synonym="cdaPSI" FT /gene_synonym="SCE63.03c" FT CDS_motif 30754..30786 FT /note="NRPS/PKS Motif: C1_LCL_004-017 (e-value: 0.016, FT bit-score: 8.1);" FT CDS_motif 30805..30918 FT /note="NRPS/PKS Motif: C2_LCL_024-062 (e-value: 4.7e-19, FT bit-score: 60.8);" FT CDS_motif 31123..31188 FT /note="NRPS/PKS Motif: C3_LCL_132-143 (e-value: 7.5e-11, FT bit-score: 34.4);" FT CDS_motif 31237..31275 FT /note="NRPS/PKS Motif: C4_LCL_164-176 (e-value: 0.0001, FT bit-score: 14.9);" FT CDS_motif 31543..31632 FT /note="NRPS/PKS Motif: C5_LCL_267-296 (e-value: 1.8e-12, FT bit-score: 39.6);" FT CDS_motif 31681..31800 FT /note="NRPS/PKS Motif: C67_LCL_14fromHMM (e-value: 6.9e-21, FT bit-score: 66.7);" FT misc_feature 32239..33438 FT /note="Pfam match to entry PF00501 AMP-binding, AMP-binding FT enzyme, score 484.60, E-value 8.1e-142" FT /gene="SCO3230" FT /gene_synonym="cdaPSI" FT /gene_synonym="SCE63.03c" FT CDS_motif 32362..32403 FT /note="NRPS/PKS Motif: NRPS-A_a2 (e-value: 0.0024, FT bit-score: 11.5);" FT misc_feature 32491..32508 FT /note="PS00343 Gram-positive cocci surface proteins 'anchor FT ing' hexapeptide." FT /gene="SCO3230" FT /gene_synonym="cdaPSI" FT /gene_synonym="SCE63.03c" FT CDS_motif 32617..32676 FT /note="NRPS/PKS Motif: NRPS-A_a3 (e-value: 2.3e-09, FT bit-score: 29.3);" FT misc_feature 32623..32658 FT /note="PS00455 Putative AMP-binding domain signature." FT /gene="SCO3230" FT /gene_synonym="cdaPSI" FT /gene_synonym="SCE63.03c" FT CDS_motif 33025..33057 FT /note="NRPS/PKS Motif: NRPS-A_a5 (e-value: 0.035, FT bit-score: 7.2);" FT CDS_motif 33157..33246 FT /note="NRPS/PKS Motif: NRPS-A_a6 (e-value: 8.7e-14, FT bit-score: 43.6);" FT CDS_motif 33331..33396 FT /note="NRPS/PKS Motif: NRPS-A_a8 (e-value: 2.1e-10, FT bit-score: 32.7);" FT CDS_motif 33610..33636 FT /note="NRPS/PKS Motif: NRPS-A_a10 (e-value: 0.84, FT bit-score: 3.2);" FT misc_feature 33691..33873 FT /note="Pfam match to entry PF00550 pp-binding, Phosphopante FT theine attachment site, score 59.80, E-value 6.3e-15" FT /gene="SCO3230" FT /gene_synonym="cdaPSI" FT /gene_synonym="SCE63.03c" FT misc_feature 33760..33807 FT /note="PS00012 Phosphopantetheine attachment site." FT /gene="SCO3230" FT /gene_synonym="cdaPSI" FT /gene_synonym="SCE63.03c" FT misc_feature 33931..35139 FT /note="Pfam match to entry PF00668 DUF4, Domain of unknown FT function, score 166.50, E-value 4.5e-46" FT /gene="SCO3230" FT /gene_synonym="cdaPSI" FT /gene_synonym="SCE63.03c" FT CDS_motif 33994..34104 FT /note="NRPS/PKS Motif: C2_LCL_024-062 (e-value: 1.8e-08, FT bit-score: 26.8);" FT CDS_motif 34318..34383 FT /note="NRPS/PKS Motif: NRPS-E2 (e-value: 2.4e-09, FT bit-score: 29.5);" FT CDS_motif 34786..34833 FT /note="NRPS/PKS Motif: NRPS-E5 (e-value: 2.1e-07, FT bit-score: 23.1);" FT CDS_motif 34888..34950 FT /note="NRPS/PKS Motif: NRPS-E6 (e-value: 1e-09, bit-score: FT 30.5);" FT misc_feature 35356..36507 FT /note="Pfam match to entry PF00668 DUF4, Domain of unknown FT function, score 275.20, E-value 8.5e-79" FT /gene="SCO3230" FT /gene_synonym="cdaPSI" FT /gene_synonym="SCE63.03c" FT CDS_motif 35431..35550 FT /note="NRPS/PKS Motif: C2_DCL_024-062 (e-value: 4.9e-14, FT bit-score: 44.6);" FT CDS_motif 35770..35835 FT /note="NRPS/PKS Motif: C3_DCL_135-156 (e-value: 1.2e-10, FT bit-score: 33.8);" FT CDS_motif 36145..36240 FT /note="NRPS/PKS Motif: C5_DCL_263-294 (e-value: 8.7e-22, FT bit-score: 69.6);" FT CDS_motif 36289..36402 FT /note="NRPS/PKS Motif: C67_DCL_14fromHMM (e-value: 1.5e-18, FT bit-score: 59.2);" FT misc_feature 36796..37929 FT /note="Pfam match to entry PF00501 AMP-binding, AMP-binding FT enzyme, score 435.90, E-value 3.5e-127" FT /gene="SCO3230" FT /gene_synonym="cdaPSI" FT /gene_synonym="SCE63.03c" FT CDS_motif 36919..36960 FT /note="NRPS/PKS Motif: NRPS-A_a2 (e-value: 0.00024, FT bit-score: 14.5);" FT CDS_motif 37117..37176 FT /note="NRPS/PKS Motif: NRPS-A_a3 (e-value: 6.6e-10, FT bit-score: 30.9);" FT misc_feature 37123..37158 FT /note="PS00455 Putative AMP-binding domain signature." FT /gene="SCO3230" FT /gene_synonym="cdaPSI" FT /gene_synonym="SCE63.03c" FT CDS_motif 37510..37536 FT /note="NRPS/PKS Motif: NRPS-A_a5 (e-value: 0.45, bit-score: FT 4.1);" FT CDS_motif 37648..37734 FT /note="NRPS/PKS Motif: NRPS-A_a6 (e-value: 1.8e-15, FT bit-score: 49.0);" FT CDS_motif 37822..37887 FT /note="NRPS/PKS Motif: NRPS-A_a8 (e-value: 3.4e-10, FT bit-score: 32.0);" FT CDS_motif 38101..38127 FT /note="NRPS/PKS Motif: NRPS-A_a10 (e-value: 3.0, bit-score: FT 1.8);" FT misc_feature 38182..38376 FT /note="Pfam match to entry PF00550 pp-binding, Phosphopante FT theine attachment site, score 87.10, E-value 1.8e-22" FT /gene="SCO3230" FT /gene_synonym="cdaPSI" FT /gene_synonym="SCE63.03c" FT CDS_motif 38185..38217 FT /note="NRPS/PKS Motif: Cy4 (e-value: 0.053, bit-score: FT 6.8);" FT misc_feature 38419..39609 FT /note="Pfam match to entry PF00668 DUF4, Domain of unknown FT function, score 322.70, E-value 4.3e-93" FT /gene="SCO3230" FT /gene_synonym="cdaPSI" FT /gene_synonym="SCE63.03c" FT CDS_motif 38440..38472 FT /note="NRPS/PKS Motif: C1_LCL_004-017 (e-value: 0.016, FT bit-score: 8.1);" FT CDS_motif 38491..38604 FT /note="NRPS/PKS Motif: C2_LCL_024-062 (e-value: 3.9e-16, FT bit-score: 51.4);" FT CDS_motif 38809..38874 FT /note="NRPS/PKS Motif: C3_LCL_132-143 (e-value: 5.1e-08, FT bit-score: 25.5);" FT CDS_motif 38923..38961 FT /note="NRPS/PKS Motif: C4_LCL_164-176 (e-value: 0.00011, FT bit-score: 14.8);" FT CDS_motif 39229..39318 FT /note="NRPS/PKS Motif: C5_LCL_267-296 (e-value: 1.3e-13, FT bit-score: 43.3);" FT CDS_motif 39367..39486 FT /note="NRPS/PKS Motif: C67_LCL_14fromHMM (e-value: 2.2e-23, FT bit-score: 74.8);" FT misc_feature 39916..41049 FT /note="Pfam match to entry PF00501 AMP-binding, AMP-binding FT enzyme, score 453.50, E-value 1.8e-132" FT /gene="SCO3230" FT /gene_synonym="cdaPSI" FT /gene_synonym="SCE63.03c" FT CDS_motif 40039..40080 FT /note="NRPS/PKS Motif: NRPS-A_a2 (e-value: 0.00024, FT bit-score: 14.5);" FT CDS_motif 40237..40296 FT /note="NRPS/PKS Motif: NRPS-A_a3 (e-value: 6.6e-10, FT bit-score: 30.9);" FT misc_feature 40243..40278 FT /note="PS00455 Putative AMP-binding domain signature." FT /gene="SCO3230" FT /gene_synonym="cdaPSI" FT /gene_synonym="SCE63.03c" FT CDS_motif 40630..40656 FT /note="NRPS/PKS Motif: NRPS-A_a5 (e-value: 0.45, bit-score: FT 4.1);" FT CDS_motif 40768..40854 FT /note="NRPS/PKS Motif: NRPS-A_a6 (e-value: 1.8e-15, FT bit-score: 49.0);" FT CDS_motif 40942..41007 FT /note="NRPS/PKS Motif: NRPS-A_a8 (e-value: 3.4e-10, FT bit-score: 32.0);" FT CDS_motif 41221..41247 FT /note="NRPS/PKS Motif: NRPS-A_a10 (e-value: 3.0, bit-score: FT 1.8);" FT misc_feature 41302..41496 FT /note="Pfam match to entry PF00550 pp-binding, Phosphopante FT theine attachment site, score 84.80, E-value 7.6e-22" FT /gene="SCO3230" FT /gene_synonym="cdaPSI" FT /gene_synonym="SCE63.03c" FT CDS_motif 41305..41337 FT /note="NRPS/PKS Motif: Cy4 (e-value: 0.16, bit-score: FT 5.3);" FT misc_feature 41371..41418 FT /note="PS00012 Phosphopantetheine attachment site." FT /gene="SCO3230" FT /gene_synonym="cdaPSI" FT /gene_synonym="SCE63.03c" FT misc_feature 41539..42723 FT /note="Pfam match to entry PF00668 DUF4, Domain of unknown FT function, score 313.50, E-value 2.5e-90" FT /gene="SCO3230" FT /gene_synonym="cdaPSI" FT /gene_synonym="SCE63.03c" FT CDS_motif 41560..41592 FT /note="NRPS/PKS Motif: C1_LCL_004-017 (e-value: 0.016, FT bit-score: 8.1);" FT CDS_motif 41611..41724 FT /note="NRPS/PKS Motif: C2_LCL_024-062 (e-value: 5.6e-18, FT bit-score: 57.3);" FT misc_feature 41827..41859 FT /note="PS00626 Regulator of chromosome condensation (RCC1) FT signature 2." FT /gene="SCO3230" FT /gene_synonym="cdaPSI" FT /gene_synonym="SCE63.03c" FT CDS_motif 41929..41994 FT /note="NRPS/PKS Motif: C3_LCL_132-143 (e-value: 2.8e-07, FT bit-score: 23.1);" FT CDS_motif 42043..42081 FT /note="NRPS/PKS Motif: C4_LCL_164-176 (e-value: 1.8e-05, FT bit-score: 17.3);" FT CDS_motif 42349..42438 FT /note="NRPS/PKS Motif: C5_LCL_267-296 (e-value: 1.9e-15, FT bit-score: 49.1);" FT CDS_motif 42487..42603 FT /note="NRPS/PKS Motif: C67_LCL_14fromHMM (e-value: 4.2e-23, FT bit-score: 73.8);" FT misc_feature 43030..44289 FT /note="Pfam match to entry PF00501 AMP-binding, AMP-binding FT enzyme, score 471.80, E-value 5.5e-138" FT /gene="SCO3230" FT /gene_synonym="cdaPSI" FT /gene_synonym="SCE63.03c" FT CDS_motif 43153..43191 FT /note="NRPS/PKS Motif: NRPS-A_a2 (e-value: 0.00076, FT bit-score: 13.0);" FT CDS_motif 43447..43506 FT /note="NRPS/PKS Motif: NRPS-A_a3 (e-value: 2.8e-09, FT bit-score: 29.0);" FT misc_feature 43453..43488 FT /note="PS00455 Putative AMP-binding domain signature." FT /gene="SCO3230" FT /gene_synonym="cdaPSI" FT /gene_synonym="SCE63.03c" FT CDS_motif 43870..43896 FT /note="NRPS/PKS Motif: NRPS-A_a5 (e-value: 0.28, bit-score: FT 4.7);" FT CDS_motif 44008..44097 FT /note="NRPS/PKS Motif: NRPS-A_a6 (e-value: 6.2e-15, FT bit-score: 47.3);" FT CDS_motif 44182..44247 FT /note="NRPS/PKS Motif: NRPS-A_a8 (e-value: 2.9e-11, FT bit-score: 35.3);" FT CDS_motif 44467..44493 FT /note="NRPS/PKS Motif: NRPS-A_a10 (e-value: 0.84, FT bit-score: 3.2);" FT misc_feature 44548..44739 FT /note="Pfam match to entry PF00550 pp-binding, Phosphopante FT theine attachment site, score 69.40, E-value 1.5e-17" FT /gene="SCO3230" FT /gene_synonym="cdaPSI" FT /gene_synonym="SCE63.03c" FT CDS_motif 44551..44583 FT /note="NRPS/PKS Motif: Cy4 (e-value: 0.19, bit-score: FT 5.0);" FT misc_feature 44617..44664 FT /note="PS00012 Phosphopantetheine attachment site." FT /gene="SCO3230" FT /gene_synonym="cdaPSI" FT /gene_synonym="SCE63.03c" FT misc_feature 44788..46041 FT /note="Pfam match to entry PF00668 DUF4, Domain of unknown FT function, score 108.80, E-value 1.1e-28" FT /gene="SCO3230" FT /gene_synonym="cdaPSI" FT /gene_synonym="SCE63.03c" FT CDS_motif 44890..44964 FT /note="NRPS/PKS Motif: C2_starter_024-063 (e-value: FT 0.00015, bit-score: 14.5);" FT CDS_motif 45205..45270 FT /note="NRPS/PKS Motif: NRPS-E2 (e-value: 4.8e-07, FT bit-score: 22.3);" FT CDS_motif 45670..45717 FT /note="NRPS/PKS Motif: NRPS-E5 (e-value: 3.7e-06, FT bit-score: 19.3);" FT CDS_motif 45787..45849 FT /note="NRPS/PKS Motif: NRPS-E6 (e-value: 4.2e-09, FT bit-score: 28.6);" FT gene 46275..57287 FT /gene="SCO3231" FT /gene_synonym="cdaPS2" FT /gene_synonym="SCE63.02c" FT CDS 46275..57287 FT /product="CDA peptide synthetase II" FT /codon_start=1 FT /gene_synonym="cdaPS2" FT /gene_synonym="SCE63.02c" FT /transl_table=11 FT /note="SCE63.02c, cdaPS2, CDA peptide synthetase II, len: FT 3670 aa; part of the calcium-dependent antibiotic (CDA) FT biosynthetic cluster from Streptomyces coelicolor. CDA is a FT peptide antibiotic which is synthesised non-ribosomally by FT a putative multifunctional peptide synthetase enzyme. This FT CDS encodes a subunit of this enzyme and is suspected to be FT responsible for the addition of 3 amino acids to the FT peptide antibiotic. This ORF overlaps the upstream (cdaPSI) FT and downstream (cdaPSIII) ORFs by one base indicating FT possible translational coupling of all three. Contains four FT separate Pfam matches to entry PF00668 DUF4, Domain of FT unknown function (U), three separate Pfam matches to entry FT PF00501 AMP-binding, AMP-binding enzyme (A) and three FT separate Pfam matches to entry PF00550 pp-binding, FT Phosphopantetheine attachment site (P). These Pfam matches FT cover the full length of the protein in the following order FT from N to C-terminal U-A-P-U-A-P-U-A-P-U. The first and FT third Pfam matches to entry PF00501 also contain Prosite FT matches to PS00455 Putative AMP-binding domain signature. FT All three Pfam matches to entry PF00550 also contain FT Prosite matches to PS00012 Phosphopantetheine attachment FT site." FT /note="smCOG: FT SMCOG1127:condensation_domain-containing_protein (Score: FT 358.0; E-value: 1.4e-108);" FT /db_xref="GI:4481933" FT /db_xref="GOA:Q9Z4X5" FT /db_xref="HSSP:1AMU" FT /db_xref="InterPro:IPR000873" FT /db_xref="InterPro:IPR001242" FT /db_xref="InterPro:IPR006162" FT /db_xref="InterPro:IPR006163" FT /db_xref="InterPro:IPR009081" FT /db_xref="InterPro:IPR010060" FT /db_xref="InterPro:IPR010071" FT /db_xref="InterPro:IPR020806" FT /db_xref="InterPro:IPR020845" FT /db_xref="UniProtKB/TrEMBL:Q9Z4X5" FT /sec_met="Type: nrps" FT /sec_met="Domains detected: Condensation (E-value: 2.5e-68, FT bitscore: 221.7, seeds: 42); Condensation (E-value: FT 1.4e-74, bitscore: 242.2, seeds: 42); Condensation FT (E-value: 7.6e-74, bitscore: 239.8, seeds: 42); FT Condensation (E-value: 4e-34, bitscore: 109.3, seeds: 42); FT AMP-binding (E-value: 5.3e-102, bitscore: 332.8, seeds: FT 400); AMP-binding (E-value: 2.8e-105, bitscore: 343.6, FT seeds: 400); AMP-binding (E-value: 7.9e-107, bitscore: FT 348.7, seeds: 400); PP-binding (E-value: 5.7e-15, bitscore: FT 47.1, seeds: 164); PP-binding (E-value: 1.7e-17, bitscore: FT 55.1, seeds: 164); PP-binding (E-value: 2.7e-15, bitscore: FT 48.1, seeds: 164)" FT /sec_met="Kind: biosynthetic" FT /sec_met="NRPS/PKS subtype: Glycopeptide NRPS" FT /sec_met="NRPS/PKS Domain: NRPS-COM_Nterm (7-34). E-value: FT 4.4e-07. Score: 20.3;" FT /sec_met="NRPS/PKS Domain: Cglyc (11-309). E-value: FT 9.2e-120. Score: 390.6;" FT /sec_met="NRPS/PKS Domain: AMP-binding (492-869). E-value: FT 4.9e-102. Score: 332.8;" FT /sec_met="NRPS/PKS Domain: PCP (950-1018). E-value: FT 6.6e-27. Score: 84.8;" FT /sec_met="NRPS/PKS Domain: Condensation_LCL (1032-1333). FT E-value: 1.8e-123. Score: 402.6;" FT /sec_met="NRPS/PKS Domain: AMP-binding (1525-1908). FT E-value: 2.6e-105. Score: 343.6;" FT /sec_met="NRPS/PKS Domain: PCP (1999-2068). E-value: FT 4.6e-29. Score: 91.8;" FT /sec_met="NRPS/PKS Domain: Condensation_LCL (2081-2382). FT E-value: 1.5e-122. Score: 399.5;" FT /sec_met="NRPS/PKS Domain: AMP-binding (2588-2996). FT E-value: 7.3e-107. Score: 348.7;" FT /sec_met="NRPS/PKS Domain: PCP (3082-3148). E-value: FT 7.5e-24. Score: 75.0;" FT /sec_met="NRPS/PKS Domain: Epimerization (3177-3482). FT E-value: 4.1e-129. Score: 422.8;" FT /translation="MSQQPTRARGKIEDILPLSPLQEGFVFLGLLHTEGPDLYIGQVAF FT DLEGPFDGARMREAARALLRRHANLRAGFRQRKNGAWAQLVLRDVDLPWQDADLSTLSE FT EERRAEADRLAAADRARRFDLGRPPLLRFTAIRLSADRVRLVMTNHHIVLDGWSMPVLL FT RELMALYAAEGDPSALPRVRPYRDYLAWLDARDRDAARDAWRRSLSGLDEATLLAPDAG FT PASTAPSQVSFTVDSEVSGALSAWARGQGVTMNTVVQGAWALALAQATGRDDVVFGATV FT SGRPPELPGVESMIGLFINTLPVRARLDQAEPLGDLFRRLQNEQARLLDHQWPGLADIQ FT HWAGHGELFDTAMVFQNYPVEEGDLTAPADPDRLRVASADIKGGTHFAVNVVATMRGAE FT LSFRVDYRPDLYDEAYARDFGRRMLRVLETLISDPDRPVAHLDTLDPAVRERVLVEWNG FT APTQLPGTPLHELISEQARLTPDAVAVVCDGTSLTYAELDGRANQLARHLLERGLGAED FT FVAIALHKSLDAVTSMLAVLKTGAAYLPIDPDYPAERITYMLDDARPALTLREPVPAAA FT YGHRPTDDVTDAERRTPWSALHAAYMIYTSGSTGRPKGVVIEHHALATYLHRARNTYTA FT MTGVTVLHSPLAFDLTITALWTPLTAGGTVHLTSLEEAEVQPSLIKATPSHLPLLTNLA FT ATASPSHTLILGGEALHTDQLTDWRTQHPGAQIINAYGPTESTVNITDHRLDGTEEGPV FT PIGRPFANTQVYVLDSALRPVAPGTTGELYLAGEQLARGYLGRPALTAERFTANPHSSV FT PGARMYRTGDLAHWNHHGHLTYDGRADHQIKLRGHRIEPGEIETTLTAQTGITQATVQL FT REDQPGDQRLVAYLVTSTGYDENTVRDALVSALPDYMVPSALVTLDALPLTPNGKLDRT FT ALPAPAYSASTTGRTPRTPREEILCTLYSEILSVNTVGIDDSFFDLGGHSLLATRLVSR FT IRTTLGRELPIRQLFETPTVAGLSRALDTSGTLRTALTARPRPERIPLSYAQQRLWFLH FT QLEGPTATYNIPTTLRLTGTLDTDALQSAFNDLLARHESLRTTYTEDDQGAQQIVLPVE FT AVATPFAVVDVAAEDVAERVAEAAAHAFDLGAEIPVRARLFRVSEREHVLLLLVHHIAS FT DAWSRGPLAQDLTAAYTARCADDAPAWQPLPVQYADYALWQQEILGDDTDPDTLAGRQL FT AYWKQQLAGLPEQLDLPTDRPRPATADHTGDRVTFTVPADLHTRLTELARETNTTAFMV FT IQAALAALLTRHGAGEDIPIGTPVAGRTDDATDHLIGFFVNTLVLRTDTSGNPTFRDLL FT TRVRDTDLTAYTHQDLPFERLVEALNPTRSLTHHPLFQTMLTLHNTQGTKTDRFAGLAA FT EVVASESVSARFDLSFALAEHFGADHSCAGMSGGVTYSTALFDRATVRDLADRLVRLLA FT AAVAHPGRSVGQLEIMDAAERRLVLQEWNDTAAEPPAASVTGLFERQARRSPGATALEF FT GEVRLSYAELNARANRLARHLVARGAAPGRFVAVALPRSAELVVTLLAVLKSGAAYLPI FT DPHYPADRVEYMLADAGPALTVTEPVAEAGLSGYGDADLGADELRGPVHGAHPAYTIYT FT SGSTGRPKGVVVPRGALDNFLADMGRRFTPGSGDRLLAVTTVGFDIAGLEIFLPLLHGA FT VLVLADEETARDPHALLHRVSASGITMVQATPSLWQGVAAVAGDELAGVRVLVGGEALP FT SELARALTDRARSVTNLYGPTEATIWATAADVAESGPVIGRPLANTSAYVLDSALRPVP FT VGVPGELYLAGEQLAQGYHLRPALTSERFTADPYGPAGTRMYRTGDLVCRRRDGALRYL FT SRVDQQVKLRGFRIELGEIEAELSRHPAVAESAVTVREDRPGDRRLVGYVVPKGPEGPA FT GPTGPVPSARELRERLRGRLPEFMVPTAFVVLDALPLTPNRKLDRKALPAPEYDGEPVG FT RGPRDPREEILCALFAEVLGVARVGIDDGFFDLGGHSLLATRLVSRIRTALGVELSVRQ FT FFETPTIAGLSGALDRAAGARAPLAARPRPERVPLSPAQQRLWFLHQFEGPSATYNMPT FT ALRLSGPVDRAALERAIGDVLVRHESLRTVFAADDGGSWQVVLPADRAVGRLDVVDVTA FT GEVAERVGEAARHAFDLTADIPFLARLFRVSDTEHVLLLLIHHIAGDGWSMAPLARDLT FT AAYAARCAGAAPDWEPLPVQYADYALWQREVLGDESDPDSVAARQLAYWKDALAGLPEQ FT LELPTDRPRPATAGYTGDRIAFTVPTALHARLTELARSTHSSLFMVVQAAFATLLTRLG FT AGEDIPVGTAVAGRNDAATEDLVGFFVNTLVLRTDTGGNPTFRELLGRVRERDLAAYAH FT QDVPFERLVEALNPARSLAHHPLYQVMITFNNTAGAGDRTAPASPDTPDVSGQAGALLN FT ATRMTAGTGVAKFDLALTFGERHDPSGGPAGMRGSLEYRTELFDRETAESVISRLLGVL FT GSVTADPDRPIGGIGLLDPAERRQVLREWNDTARPQREGTLPRLFEEQVARTPRRPAFS FT AAGTTLTYAELNSRANRLAHLLAESGAGPEQVVAISLPPSVEMGVAVLAVLKTGAAYLP FT VDPGSPRERIATMAEDAAPVCALTTSAVPAGVFPAELPRLLLDDPDVTARLAAQPAHDL FT TDEDRTQPLSPWNAAYIIYTSGSTGRPKGVLVEHQPVLNYLAVSAELYPGVAGNALLHS FT PLSFDLTVTGLFAPLLNGGCVHLADLEELHARALDGEVPDLPQTTFLKATPSHLPLITG FT LPGVCVPDGELVLGGESLTGRAVRTLLAAHPGARVLNEYGPTETIVGCTTWRVEAPDDL FT ADGVLTIGRPFPNTRMLVLDPYLQPVPAGVPGELYVSGVQLARGYLNRPGQSASRFVAN FT PFEGPGERMYRTGDIVRWNRRGDLEFISRVDDQVKIRGFRVELGEVESALSRQPGVPEA FT VAVVREDRPGDRRLVAYLVTGAGPVPVPSDEELRERLRETLPDYMVPSAFVRLPELPLT FT GNGKLDRGRLPAPDYAAAGTGRAPVTAREELLCALFAEALGLESVGVDDGFFDLGGDSI FT LSIQLVSRARAKGLTLSVRDVFEHQSVARVAEALELAEAQAADGAAGASAGAVPGAAEE FT EAAASGPVPATPIMGWFAALGGPVAPFNQSVVVSVPADLDAERLVAALGALLDRHDSLR FT LRVAADWSMSVPEPEPGGTDAAGLLTRRAAGDVDDAGLHALLAEAGAAERDRLSPADGR FT MLRACHVDRGPDRPGLLVLVAHHLAVDAVSWRLLVPDLAAAYEGRPLSPAGTGWRRWAS FT ALRDLAGSPVTEAETDHWLDAARPAAEPADPVLDPARDTHARSGQVVLDLDPDTTDALL FT TWVPGVFRAEINDLLLTAFGLAVADWRRDRGARGTAPVTVDLESHGRHEHLVPGADLTR FT TTGWFTSMHPVPLHPEVDDPDWAEVWDGGAAAGRALKRVKEQLRAVPRDGVGHGLLRHL FT NPRTRDRFAALPTPAYGFNYLGRHTGGRGGGAPGGGAGPEPWSVLGRGVAGQHPDTPLA FT HPVELVAGAHDTDAGPTLHSVWTYADAVLSETEVRRLGEGWFRALKALVEHAGRPEASG FT LTPSDVSLTSLSEDDISRLESEWGSL" FT /gene="SCO3231" FT /protein_id="CAB38517.1" FT misc_feature 46308..47462 FT /note="Pfam match to entry PF00668 DUF4, Domain of unknown FT function, score 290.10, E-value 2.7e-83" FT /gene="SCO3231" FT /gene_synonym="cdaPS2" FT /gene_synonym="SCE63.02c" FT CDS_motif 46383..46502 FT /note="NRPS/PKS Motif: C2_DCL_024-062 (e-value: 7.2e-16, FT bit-score: 50.4);" FT CDS_motif 46719..46784 FT /note="NRPS/PKS Motif: C3_DCL_135-156 (e-value: 3.4e-13, FT bit-score: 41.9);" FT CDS_motif 46827..46850 FT /note="NRPS/PKS Motif: C4_LCL_164-176 (e-value: 17.0, FT bit-score: -1.1);" FT CDS_motif 47094..47189 FT /note="NRPS/PKS Motif: C5_DCL_263-294 (e-value: 4.1e-22, FT bit-score: 70.6);" FT CDS_motif 47238..47351 FT /note="NRPS/PKS Motif: C67_DCL_14fromHMM (e-value: 7.3e-19, FT bit-score: 60.2);" FT misc_feature 47751..48881 FT /note="Pfam match to entry PF00501 AMP-binding, AMP-binding FT enzyme, score 446.50, E-value 2.3e-130" FT /gene="SCO3231" FT /gene_synonym="cdaPS2" FT /gene_synonym="SCE63.02c" FT CDS_motif 47874..47915 FT /note="NRPS/PKS Motif: NRPS-A_a2 (e-value: 0.00011, FT bit-score: 15.5);" FT CDS_motif 48072..48131 FT /note="NRPS/PKS Motif: NRPS-A_a3 (e-value: 3e-10, FT bit-score: 31.9);" FT misc_feature 48078..48113 FT /note="PS00455 Putative AMP-binding domain signature." FT /gene="SCO3231" FT /gene_synonym="cdaPS2" FT /gene_synonym="SCE63.02c" FT CDS_motif 48465..48491 FT /note="NRPS/PKS Motif: NRPS-A_a5 (e-value: 0.19, bit-score: FT 5.1);" FT CDS_motif 48600..48686 FT /note="NRPS/PKS Motif: NRPS-A_a6 (e-value: 3.5e-15, FT bit-score: 48.1);" FT CDS_motif 48774..48839 FT /note="NRPS/PKS Motif: NRPS-A_a8 (e-value: 1.6e-10, FT bit-score: 33.1);" FT CDS_motif 49047..49073 FT /note="NRPS/PKS Motif: NRPS-A_a10 (e-value: 1.2, bit-score: FT 2.8);" FT misc_feature 49128..49322 FT /note="Pfam match to entry PF00550 pp-binding, Phosphopante FT theine attachment site, score 78.00, E-value 5.9e-20" FT /gene="SCO3231" FT /gene_synonym="cdaPS2" FT /gene_synonym="SCE63.02c" FT misc_feature 49197..49244 FT /note="PS00012 Phosphopantetheine attachment site." FT /gene="SCO3231" FT /gene_synonym="cdaPS2" FT /gene_synonym="SCE63.02c" FT misc_feature 49365..50543 FT /note="Pfam match to entry PF00668 DUF4, Domain of unknown FT function, score 332.60, E-value 4.3e-96" FT /gene="SCO3231" FT /gene_synonym="cdaPS2" FT /gene_synonym="SCE63.02c" FT CDS_motif 49386..49418 FT /note="NRPS/PKS Motif: C1_LCL_004-017 (e-value: 0.007, FT bit-score: 9.1);" FT CDS_motif 49437..49550 FT /note="NRPS/PKS Motif: C2_LCL_024-062 (e-value: 2.2e-18, FT bit-score: 58.6);" FT CDS_motif 49755..49820 FT /note="NRPS/PKS Motif: C3_LCL_132-143 (e-value: 6.2e-09, FT bit-score: 28.4);" FT CDS_motif 49869..49907 FT /note="NRPS/PKS Motif: C4_LCL_164-176 (e-value: 5.2e-05, FT bit-score: 15.8);" FT CDS_motif 50175..50264 FT /note="NRPS/PKS Motif: C5_LCL_267-296 (e-value: 7.7e-15, FT bit-score: 47.2);" FT CDS_motif 50313..50432 FT /note="NRPS/PKS Motif: C67_LCL_14fromHMM (e-value: 4.9e-22, FT bit-score: 70.4);" FT misc_feature 50850..51998 FT /note="Pfam match to entry PF00501 AMP-binding, AMP-binding FT enzyme, score 472.70, E-value 3e-138" FT /gene="SCO3231" FT /gene_synonym="cdaPS2" FT /gene_synonym="SCE63.02c" FT CDS_motif 50973..51014 FT /note="NRPS/PKS Motif: NRPS-A_a2 (e-value: 8.4e-05, FT bit-score: 15.9);" FT CDS_motif 51171..51227 FT /note="NRPS/PKS Motif: NRPS-A_a3 (e-value: 2.3e-08, FT bit-score: 26.2);" FT CDS_motif 51594..51617 FT /note="NRPS/PKS Motif: NRPS-A_a5 (e-value: 0.21, bit-score: FT 5.1);" FT CDS_motif 51717..51806 FT /note="NRPS/PKS Motif: NRPS-A_a6 (e-value: 2.7e-14, FT bit-score: 45.3);" FT CDS_motif 51891..51956 FT /note="NRPS/PKS Motif: NRPS-A_a8 (e-value: 1.2e-10, FT bit-score: 33.4);" FT CDS_motif 52197..52220 FT /note="NRPS/PKS Motif: NRPS-A_a10 (e-value: 3.0, bit-score: FT 1.8);" FT misc_feature 52275..52469 FT /note="Pfam match to entry PF00550 pp-binding, Phosphopante FT theine attachment site, score 88.00, E-value 1e-22" FT /gene="SCO3231" FT /gene_synonym="cdaPS2" FT /gene_synonym="SCE63.02c" FT misc_feature 52344..52391 FT /note="PS00012 Phosphopantetheine attachment site." FT /gene="SCO3231" FT /gene_synonym="cdaPS2" FT /gene_synonym="SCE63.02c" FT misc_feature 52512..53732 FT /note="Pfam match to entry PF00668 DUF4, Domain of unknown FT function, score 326.10, E-value 3.9e-94" FT /gene="SCO3231" FT /gene_synonym="cdaPS2" FT /gene_synonym="SCE63.02c" FT CDS_motif 52533..52565 FT /note="NRPS/PKS Motif: C1_LCL_004-017 (e-value: 0.022, FT bit-score: 7.8);" FT CDS_motif 52584..52700 FT /note="NRPS/PKS Motif: C2_LCL_024-062 (e-value: 2.5e-18, FT bit-score: 58.5);" FT CDS_motif 52902..52967 FT /note="NRPS/PKS Motif: C3_LCL_132-143 (e-value: 3e-10, FT bit-score: 32.5);" FT CDS_motif 53016..53054 FT /note="NRPS/PKS Motif: C4_LCL_164-176 (e-value: 8.1e-06, FT bit-score: 18.3);" FT CDS_motif 53322..53411 FT /note="NRPS/PKS Motif: C5_LCL_267-296 (e-value: 5.9e-15, FT bit-score: 47.6);" FT CDS_motif 53460..53576 FT /note="NRPS/PKS Motif: C67_LCL_14fromHMM (e-value: 3e-22, FT bit-score: 71.1);" FT misc_feature 54039..55265 FT /note="Pfam match to entry PF00501 AMP-binding, AMP-binding FT enzyme, score 428.90, E-value 4.6e-125" FT /gene="SCO3231" FT /gene_synonym="cdaPS2" FT /gene_synonym="SCE63.02c" FT CDS_motif 54162..54203 FT /note="NRPS/PKS Motif: NRPS-A_a2 (e-value: 0.0002, FT bit-score: 14.7);" FT CDS_motif 54417..54476 FT /note="NRPS/PKS Motif: NRPS-A_a3 (e-value: 2.1e-10, FT bit-score: 32.4);" FT misc_feature 54423..54458 FT /note="PS00455 Putative AMP-binding domain signature." FT /gene="SCO3231" FT /gene_synonym="cdaPS2" FT /gene_synonym="SCE63.02c" FT CDS_motif 54840..54866 FT /note="NRPS/PKS Motif: NRPS-A_a5 (e-value: 0.72, bit-score: FT 3.5);" FT CDS_motif 54984..55073 FT /note="NRPS/PKS Motif: NRPS-A_a6 (e-value: 1.7e-15, FT bit-score: 49.1);" FT CDS_motif 55158..55223 FT /note="NRPS/PKS Motif: NRPS-A_a8 (e-value: 5.8e-11, FT bit-score: 34.4);" FT CDS_motif 55443..55469 FT /note="NRPS/PKS Motif: NRPS-A_a10 (e-value: 9.8, bit-score: FT 0.4);" FT misc_feature 55524..55715 FT /note="Pfam match to entry PF00550 pp-binding, Phosphopante FT theine attachment site, score 71.90, E-value 2.9e-18" FT /gene="SCO3231" FT /gene_synonym="cdaPS2" FT /gene_synonym="SCE63.02c" FT misc_feature 55593..55640 FT /note="PS00012 Phosphopantetheine attachment site" FT /gene="SCO3231" FT /gene_synonym="cdaPS2" FT /gene_synonym="SCE63.02c" FT misc_feature 55800..57047 FT /note="Pfam match to entry PF00668 DUF4, Domain of unknown FT function, score 87.50, E-value 2.7e-22" FT /gene="SCO3231" FT /gene_synonym="cdaPS2" FT /gene_synonym="SCE63.02c" FT CDS_motif 55869..55973 FT /note="NRPS/PKS Motif: C2_LCL_024-062 (e-value: 7e-07, FT bit-score: 21.7);" FT CDS_motif 56193..56258 FT /note="NRPS/PKS Motif: NRPS-E2 (e-value: 1.9e-09, FT bit-score: 29.8);" FT CDS_motif 56664..56711 FT /note="NRPS/PKS Motif: NRPS-E5 (e-value: 1.3e-06, FT bit-score: 20.7);" FT CDS_motif 56790..56852 FT /note="NRPS/PKS Motif: NRPS-E6 (e-value: 2.4e-09, FT bit-score: 29.4);" FT misc_feature 57287..58267 FT /note="Pfam match to entry PF00668 DUF4, Domain of unknown FT function, score 187.70, E-value 1.9e-52." FT /gene="SCO3232" FT /gene_synonym="cdaPS3" FT /gene_synonym="SCE29.01" FT /gene_synonym="SCE63.01" FT gene 57287..64540 FT /gene="SCO3232" FT /gene_synonym="cdaPS3" FT /gene_synonym="SCE29.01" FT /gene_synonym="SCE63.01" FT CDS 57287..64540 FT /product="CDA peptide synthetase III" FT /codon_start=1 FT /gene_synonym="cdaPS3" FT /gene_synonym="SCE29.01" FT /gene_synonym="SCE63.01" FT /transl_table=11 FT /note="SCE63.01, partial CDS, cdaPS3, CDA peptide FT synthetase III, len: >332 aa; Constitutes the N-terminus of FT cdaPS3, CDA peptide synthetase III, part of the FT calcium-dependent antibiotic (CDA) biosynthetic cluster FT from Streptomyces coelicolor. CDA is a peptide antibiotic FT which is synthesised non-ribosomally by a putative FT multifunctional peptide synthetase enzyme. This partial CDS FT encodes the N-terminus of a subunit of this enzyme FT suspected to be responsible for the addition of 2 amino FT acids to the peptide antibiotic. This ORF overlaps the FT upstream (cdaPSII) by one base indicating possible FT translational coupling. Contains Pfam match to entry FT PF00668 DUF4, Domain of unknown function.; SCE29.01, FT partial CDS, cdaPS3, CDA peptide synthetase III, len: FT >332aa; Constitutes the the majority of cdaPS3, CDA peptide FT synthetase III, part of the calcium-dependent antibiotic FT (CDA) biosynthetic cluster from Streptomyces coelicolor. FT CDA is a peptide antibiotic which is synthesised FT non-ribosomally by a putative multifunctional peptide FT synthetase enzyme. This partial CDS encodes a subunit of FT this enzyme suspected to be responsible for the addition of FT 2 amino acids to the peptide antibiotic. This ORF overlaps FT the upstream (cdaPSII) by one base indicating possible FT translational coupling. Contains two Pfam matches to entry FT PF00501 AMP-binding, AMP-binding enzyme, a Pfam match to FT entry PF00668 DUF4, Domain of unknown function, a Pfam FT match to entry PF00975 Thioesterase, Thioesterase domain FT and two Pfam matches to entry PF00550 pp-binding, FT Phosphopantetheine attachment site. Each PF00501 contains a FT Prosite match PS00455 Putative AMP-binding domain FT signature. Each PF00550 contains a Prosite match PS00012 FT Phosphopantetheine attachment site." FT /note="smCOG: FT SMCOG1127:condensation_domain-containing_protein (Score: FT 346.1; E-value: 6.1e-105);" FT /db_xref="GI:24426512" FT /db_xref="GOA:Q8CJX2" FT /db_xref="HSSP:1AMU" FT /db_xref="InterPro:IPR000873" FT /db_xref="InterPro:IPR001031" FT /db_xref="InterPro:IPR001242" FT /db_xref="InterPro:IPR006162" FT /db_xref="InterPro:IPR006163" FT /db_xref="InterPro:IPR009081" FT /db_xref="InterPro:IPR010071" FT /db_xref="InterPro:IPR020806" FT /db_xref="InterPro:IPR020845" FT /db_xref="UniProtKB/TrEMBL:Q8CJX2" FT /sec_met="Type: nrps" FT /sec_met="Domains detected: Condensation (E-value: 6.4e-68, FT bitscore: 220.3, seeds: 42); Condensation (E-value: FT 2.8e-75, bitscore: 244.5, seeds: 42); AMP-binding (E-value: FT 1.8e-104, bitscore: 340.9, seeds: 400); AMP-binding FT (E-value: 7.9e-112, bitscore: 365.1, seeds: 400); FT PP-binding (E-value: 2.3e-15, bitscore: 48.3, seeds: 164); FT PP-binding (E-value: 1.9e-16, bitscore: 51.8, seeds: 164)" FT /sec_met="Kind: biosynthetic" FT /sec_met="NRPS/PKS subtype: NRPS" FT /sec_met="NRPS/PKS Domain: NRPS-COM_Nterm (2-28). E-value: FT 1.7e-11. Score: 34.5;" FT /sec_met="NRPS/PKS Domain: Condensation_DCL (6-302). FT E-value: 3e-116. Score: 379.0;" FT /sec_met="NRPS/PKS Domain: AMP-binding (488-898). E-value: FT 1.6e-104. Score: 340.9;" FT /sec_met="NRPS/PKS Domain: PCP (980-1048). E-value: FT 5.7e-27. Score: 85.0;" FT /sec_met="NRPS/PKS Domain: Condensation_LCL (1062-1363). FT E-value: 3.3e-120. Score: 391.8;" FT /sec_met="NRPS/PKS Domain: AMP-binding (1562-1960). FT E-value: 7.3e-112. Score: 365.1;" FT /sec_met="NRPS/PKS Domain: PCP (2042-2110). E-value: FT 1.1e-29. Score: 93.8;" FT /sec_met="NRPS/PKS Domain: Thioesterase (2129-2369). FT E-value: 2.3e-40. Score: 130.7;" FT /translation="MAKSGLEDILPLSPLQEGMLFHNLFDEEELDAYNVQVFIDLEGGT FT DPERLRRAGQALLERHANLRAAFRHEGLKRPVQLIPRRVVLPWGEEDLSGVAEPEREAA FT AERVAERDRWTRFDLSRPPLIRFTLVRLGPARHRLLLTLHHILADGWSMPILLRELMTL FT YTVHGDGTALPRVRPYRDYLGWLGGRDRDAARQAWTEAFAGLDAPSIVAPGRGALTAAP FT ERIDFSEDEAASAALTRFARSNGLTVNTVIQGCWGLVLSHLTGRDDVVFGVTVSGRPPE FT LPGIDTMVGLFMNTLPLRVRLRPAETLTGFLRRLQGEQARLIDHQWVGLAEIQRWAGSG FT ELFDTAMVFENYPLNSSRGRPPGAAPDADLPTVLGVRSKDQMHYPLGLLALPRETLRFS FT LGYLPQVFDPARVEAVIAAFRRALRTVLDAPDTRVGAVALLDPEVRGTVLEKWSGSDDV FT RPAERFTDLFEEQVARTPGKTALIAPDGRLTYAELDAAANRLARRLVELGVGPERHVAV FT AVGRRTELVVGMLAVLKAGGAYVPVDPEYPPDRIRHMIQDADPALVLTTSDVDDRIGEE FT CCGPLTFVMDDPNTGTSLGRHSGTALTDADRAAPLLPGHPAYVIYTSGTTGRPKGVVVE FT HRALSAFVRHCRSSQAPDISGLSVMQASASFDQSVGSLHAPLISGGCVRLTDLRALAET FT AGSEPGFHRATFMKGTPSHLALLATMPPEVAPSGTLTLGGEELRGEILAPWREAAGDVT FT VVNVYGPTEATGHCLEHWIAPDRTVEPGPVPIGTPHEGVRVYVLDSALRPVAPGLDGEV FT YLAGVQLARGYLGRGGLTAERFTADPFGAPGSRMYRTGDVAHWNEAGELVFAGRADRQV FT KLRGYRIELGEIEAAVAGGPGVRQAAVVLREDRPGDQRLVAYVVPDPGHWDEAAARARL FT ALSLPDFMMPSAFVALDALPLSPNGKLDRAALPAPTYTGRTAGRAPRTPAEEILCDLYA FT EVLSLPGVTVDDDFFDLGGHSLLATRLVSRVRTTLGAELSIRQFFEAPTPAALAVVLAG FT AGRARAALTARPRPERLPLSYAQQRLWFLHLLEGPSPTYNIPTVLRLSGPLRPDALRAA FT LLDVVGRHESLRTTFTEDERGARQVVHPADGVRPVFETAESTEADYEADLARAARHAFD FT LGAEIPVRARLLRLSEREHVLLLLVHHIASDAWSRGPLAQDLTAAYTARCAGDAPAWQP FT LPVQYADYALWQQEILGDDTDPDTLAGRQLAYWKQQLAGLPERLDLPTDRPRPATADHT FT GDRVEFALPADLHTRLTELARATDTTLYMVLQAALATLLTRHGAGEDIPIGTPVAGRTD FT DATDHLVGFFVNTLVLRTDTSGNPTFRDLLTRVRDTDLTAYTHQDLPFERLVEALNPTR FT SLTHHPLFQVVLSLRSTAPRRADGEGAPALPGGLRVSGTGGAAATAAKVDLGFSVTERR FT AADHTPDGVAGVLDFRTDLFDRGTAQGLVDRLVRVLADAAAHPDRPLSRIDVLGPRERH FT RVVEEWNATAKGLAPATLPELFERHVRERPGAEAVVAGDTSLSYAELNARANRLARLLV FT ARGAGPERLVALALPRSAELPVAVLAVAKAGAAYLPLDPAHPAERIAGTLDDAAPVALL FT TTAAVAAGLPDTDVPRLLLDEEPAAGGGEDAADLTDADRLAPLLPGHPAYVIYTSGTTG FT RPKGVTVTHSGLPALLDIFTSQLDVVPGSRVLHHLSPAFDGGFWELAMGLLTGAALVVV FT EPGTVPGPALAALAVRHRVTHAAITPAVLQLIPEGALPAGTTLVVAAETCPPELVARWS FT AGRLMRNSYGPTETTVCATMSAPLAGAAVPPIGRPIADTAGYVLDDALQPVPPGVPGEL FT YVRGPGLARGYLGRPSLTAGRFVACPFGPAGGVMYRTGDLVRHRADGDLEYLGRTDTQV FT KLRGMRVEPAEIEAVTAGLPGVAQAAVLVREDTPGDRRLVGYVVPDAGASVDPGALRQA FT LRGSLPEYMVPAALVVLDALPLTTNGKLDHRALPAPEYRTVEGRSPRTPREEALCRLFA FT EVLGLELVGLDDGFFDLGGHSLLAIRLVERVRAELGEELGVRDLFAAPTVADLAVRLAA FT RGGREPMERLLPLRAAGTARPVFCVHPGSGMSWCYSGLVRHLPPGIPVYGLQAAGLDGD FT GPLPATLQEMAAEYADLVRQTQPEGPYRLLGWSLGGNVAFAMARELRARGQEVELLAFL FT DAYPRRAGAGPEAPLAEVFAHNLRDAGFDVAEEELTGGRFPTARYRAFLNAAGDPMGRL FT DEAELAAVLEVFMNNAALMRGHTPGTYDGDVLVLAAERADGDKLARRGAESWRPHVRGR FT IERVGVDADHLGLVQSDAALAVIGRALAGRLDPATGHAASAAVPETEGVTAMNPSPEPA FT PSPESLDSTEVA" FT /gene="SCO3232" FT /protein_id="CAD55498.1" FT CDS_motif 57317..57352 FT /note="NRPS/PKS Motif: C1_dual_004-017 (e-value: 0.00013, FT bit-score: 14.7);" FT CDS_motif 57377..57496 FT /note="NRPS/PKS Motif: C2_DCL_024-062 (e-value: 1.4e-16, FT bit-score: 52.8);" FT CDS_motif 57713..57778 FT /note="NRPS/PKS Motif: C3_DCL_135-156 (e-value: 8.5e-13, FT bit-score: 40.6);" FT CDS_motif 58088..58183 FT /note="NRPS/PKS Motif: C5_DCL_263-294 (e-value: 1.1e-19, FT bit-score: 62.9);" FT misc_feature complement(58185..58285) FT /note="Overlap with Streptomyces coelicolor cosmid StE63." FT CDS_motif 58232..58345 FT /note="NRPS/PKS Motif: C67_DCL_14fromHMM (e-value: 1.8e-20, FT bit-score: 65.4);" FT misc_feature 58751..59978 FT /note="Pfam match to entry PF00501 AMP-binding, AMP-binding FT enzyme, score 385.20, E-value 6.6e-112" FT /gene="SCO3232" FT /gene_synonym="cdaPS3" FT /gene_synonym="SCE29.01" FT /gene_synonym="SCE63.01" FT CDS_motif 58874..58915 FT /note="NRPS/PKS Motif: NRPS-A_a2 (e-value: 1.3e-05, FT bit-score: 18.3);" FT CDS_motif 59135..59194 FT /note="NRPS/PKS Motif: NRPS-A_a3 (e-value: 1e-10, FT bit-score: 33.3);" FT misc_feature 59141..59176 FT /note="PS00455 Putative AMP-binding domain signature." FT /gene="SCO3232" FT /gene_synonym="cdaPS3" FT /gene_synonym="SCE29.01" FT /gene_synonym="SCE63.01" FT CDS_motif 59558..59581 FT /note="NRPS/PKS Motif: NRPS-A_a5 (e-value: 0.38, bit-score: FT 4.3);" FT CDS_motif 59702..59788 FT /note="NRPS/PKS Motif: NRPS-A_a6 (e-value: 3.6e-11, FT bit-score: 35.3);" FT CDS_motif 59873..59938 FT /note="NRPS/PKS Motif: NRPS-A_a8 (e-value: 2.3e-11, FT bit-score: 35.6);" FT misc_feature 60230..60422 FT /note="Pfam match to entry PF00550 pp-binding, FT Phosphopantetheine attachment site, score 78.40, E-value FT 4.6e-20" FT /gene="SCO3232" FT /gene_synonym="cdaPS3" FT /gene_synonym="SCE29.01" FT /gene_synonym="SCE63.01" FT misc_feature 60299..60346 FT /note="PS00012 Phosphopantetheine attachment site." FT /gene="SCO3232" FT /gene_synonym="cdaPS3" FT /gene_synonym="SCE29.01" FT /gene_synonym="SCE63.01" FT misc_feature 60467..61664 FT /note="Pfam match to entry PF00668 DUF4, Domain of unknown FT function, score 335.30, E-value 6.9e-97" FT /gene="SCO3232" FT /gene_synonym="cdaPS3" FT /gene_synonym="SCE29.01" FT /gene_synonym="SCE63.01" FT CDS_motif 60488..60520 FT /note="NRPS/PKS Motif: C1_LCL_004-017 (e-value: 0.0042, FT bit-score: 9.7);" FT CDS_motif 60539..60652 FT /note="NRPS/PKS Motif: C2_LCL_024-062 (e-value: 5e-18, FT bit-score: 57.5);" FT CDS_motif 60857..60922 FT /note="NRPS/PKS Motif: C3_LCL_132-143 (e-value: 4e-09, FT bit-score: 29.0);" FT CDS_motif 60971..61009 FT /note="NRPS/PKS Motif: C4_LCL_164-176 (e-value: 3.3e-05, FT bit-score: 16.4);" FT CDS_motif 61277..61366 FT /note="NRPS/PKS Motif: C5_LCL_267-296 (e-value: 7.1e-15, FT bit-score: 47.3);" FT CDS_motif 61415..61534 FT /note="NRPS/PKS Motif: C67_LCL_14fromHMM (e-value: 1.2e-21, FT bit-score: 69.2);" FT misc_feature 61973..63164 FT /note="Pfam match to entry PF00501 AMP-binding, AMP-binding FT enzyme, score 448.70, E-value 5.2e-131" FT /gene="SCO3232" FT /gene_synonym="cdaPS3" FT /gene_synonym="SCE29.01" FT /gene_synonym="SCE63.01" FT CDS_motif 62096..62137 FT /note="NRPS/PKS Motif: NRPS-A_a2 (e-value: 0.00011, FT bit-score: 15.5);" FT CDS_motif 62345..62404 FT /note="NRPS/PKS Motif: NRPS-A_a3 (e-value: 9.7e-10, FT bit-score: 30.4);" FT misc_feature 62351..62386 FT /note="PS00455 Putative AMP-binding domain signature." FT /gene="SCO3232" FT /gene_synonym="cdaPS3" FT /gene_synonym="SCE29.01" FT /gene_synonym="SCE63.01" FT CDS_motif 62753..62782 FT /note="NRPS/PKS Motif: NRPS-A_a5 (e-value: 0.011, FT bit-score: 8.6);" FT CDS_motif 62885..62974 FT /note="NRPS/PKS Motif: NRPS-A_a6 (e-value: 1e-15, FT bit-score: 49.8);" FT CDS_motif 63059..63124 FT /note="NRPS/PKS Motif: NRPS-A_a8 (e-value: 3.1e-10, FT bit-score: 32.1);" FT misc_feature 63416..63608 FT /note="Pfam match to entry PF00550 pp-binding, FT Phosphopantetheine attachment site, score 76.90, E-value FT 1.2e-19" FT /gene="SCO3232" FT /gene_synonym="cdaPS3" FT /gene_synonym="SCE29.01" FT /gene_synonym="SCE63.01" FT misc_feature 63485..63532 FT /note="PS00012 Phosphopantetheine attachment site." FT /gene="SCO3232" FT /gene_synonym="cdaPS3" FT /gene_synonym="SCE29.01" FT /gene_synonym="SCE63.01" FT misc_feature 63674..64403 FT /note="Pfam match to entry PF00975 Thioesterase, FT Thioesterase domain, score 139.00, E-value 8.5e-38" FT /gene="SCO3232" FT /gene_synonym="cdaPS3" FT /gene_synonym="SCE29.01" FT /gene_synonym="SCE63.01" FT CDS_motif 63677..63706 FT /note="NRPS/PKS Motif: NRPS-beforete1 (e-value: 0.004, FT bit-score: 10.2);" FT CDS_motif 63857..63931 FT /note="NRPS/PKS Motif: NRPS-te1 (e-value: 1.1e-15, FT bit-score: 49.8);" FT gene 64544..65362 FT /gene="SCO3233" FT /gene_synonym="SCE29.0" FT CDS 64544..65362 FT /product="putative hydrolase" FT /codon_start=1 FT /gene_synonym="SCE29.0" FT /transl_table=11 FT /note="SCE29.02, probable hydrolase, len: 272 aa; similar FT to many e.g. TR:O52809 (EMBL:AJ223998) from the vancomycin FT biosynthesis cluster of Amycolatopsis orientalis (276 aa) FT fasta scores; opt: 892, z-score: 1028.9, E(): 0, (50.9% FT identity in 271 aa overlap) and TR:O67982 (EMBL:AF003947) FT PcaL; single polypeptide combining 3-oxoadipate FT enol-lactone hydrolyzing and 4-carboxymuconolactone FT decarboxylating activityfrom Rhodococcus opacus (400 aa) FT fasta scores; opt: 288, z-score: 335.4, E(): 2.3e-11, FT (32.0% identity in 256 aa overlap). Contains Pfam match to FT entry PF00561 abhydrolase, alpha/beta hydrolase fold, score FT 77.80, E-value 2.2e-19." FT /note="smCOG: SMCOG1036:alpha/beta_hydrolase_fold_protein FT (Score: 162.1; E-value: 3.7e-49);" FT /db_xref="GI:4490980" FT /db_xref="GOA:Q9Z4Z8" FT /db_xref="InterPro:IPR000073" FT /db_xref="InterPro:IPR000639" FT /db_xref="UniProtKB/TrEMBL:Q9Z4Z8" FT /translation="MPVLTVNGIRINYYDDAPPAGAQNAPAVLLVMGSGGSGRAWHLHQ FT VPALVAAGFRVISFDNRGIAPSEECPGGFGIDDLVADTAALVEELRLGPCRVAGISMGA FT HIAQELALSRPDLVDRLVLMATRARPDALREALCRAEMELYDQGIRLPAAYEAVVQAMQ FT NLSPRTLDNDVQARDWLDVLELTRRSGAGYRAQLGVRVDGDRREAYRGIRAATRVVAFQ FT DDLIAPPHLGREVADAIPGAEYELVPDCGHYGYLESPDAVNKSLVEFLRR" FT /gene="SCO3233" FT /protein_id="CAB38877.1" FT misc_feature 64703..65353 FT /note="Pfam match to entry PF00561 abhydrolase, alpha/beta FT hydrolase fold, score 77.80, E-value 2.2e-19." FT /gene="SCO3233" FT /gene_synonym="SCE29.0" FT gene 65374..66276 FT /gene="SCO3234" FT /gene_synonym="SCE29.03" FT CDS 65374..66276 FT /product="putative phosphotransferase" FT /codon_start=1 FT /gene_synonym="SCE29.03" FT /transl_table=11 FT /note="SCE29.03, possible phosphotransferase, len: 300 aa; FT weak similarity to TR:P72441 (EMBL:U70376) spectinomycin FT phosphotransferase from spectinomycin producer Streptomyces FT flavopersicus (330 aa) fasta scores; opt: 145, z-score: FT 177.0, E(): 0.015, (25.3% identity in 261 aa overlap)." FT /db_xref="GI:4490981" FT /db_xref="GOA:Q9Z4Z7" FT /db_xref="InterPro:IPR002575" FT /db_xref="InterPro:IPR011009" FT /db_xref="UniProtKB/Swiss-Prot:Q9Z4Z7" FT /translation="MKTESDVQTGAPTAADGALIALAREVCPGFAPGEVVYRSRTSLVV FT GGELDGVEALAKVRTPDWRRQCLREIDTYDLFDAVPPPVPVPRRFASDRERAVLVMERL FT TGEVLAPDRFPVTPVSREDLAGVLEAVERLRHWRPAAAGAWAVDYRGMLEGVHAQGVFD FT DGHWADLLRLLELSGAPREFGHGDLVLANVVRSRGRQVLIDWASSALYLPGLDLAQLWM FT LLGDVPGARARIEVEVADRADDRDGMMPFLVNLTLLLYRERRAHRRFTDDASRARAVGL FT DAAWELTRHRVRQCLATAG" FT /gene="SCO3234" FT /protein_id="CAB38878.1" FT stem_loop 66281..66343 FT /note="Possible stem loop with 8 base loop." FT gene complement(66352..68199) FT /gene="SCO3235" FT /gene_synonym="SCE29.04c" FT CDS complement(66352..68199) FT /product="putative ABC transporter" FT /codon_start=1 FT /gene_synonym="SCE29.04c" FT /transl_table=11 FT /note="SCE29.04c, probable ABC transporter, len: 615aa; FT similar to many eg. TR:D1035364 (EMBL:AB019513) ABC FT transporter from Streptomyces coelicolor fasta scores; opt: FT 783, z-score: 794.3, E(): 0, (42.8% identity in 596 aa FT overlap). C-terminal half contains Pfam match to entry FT PF00005 ABC_tran, ABC transporter (score 184.50, E-value FT 1.7e-51) which itself contains Prosite matches to PS00211 FT ABC transporters family signature and PS00017 FT ATP/GTP-binding site motif A (P-loop). N-terminal half FT contains Pfam match to entry PF00664 ABC_membrane, ABC FT transporter transmembrane region., score 129.80, E-value FT 4.9e-35. Contains probable transmembrane hydrophobic FT regions." FT /note="smCOG: SMCOG1288:ABC_transporter_related_protein FT (Score: 339.0; E-value: 8.6e-103);" FT /db_xref="GI:4490982" FT /db_xref="GOA:Q9Z4Z6" FT /db_xref="HSSP:1MV5" FT /db_xref="InterPro:IPR001140" FT /db_xref="InterPro:IPR003439" FT /db_xref="InterPro:IPR003593" FT /db_xref="InterPro:IPR011527" FT /db_xref="InterPro:IPR017871" FT /db_xref="InterPro:IPR017940" FT /db_xref="UniProtKB/TrEMBL:Q9Z4Z6" FT /translation="MTSTQTRERPPARKTGAKNAPEPGPPAPPVRKVGLRSLFPYLQGY FT WPTLGIVAVLSLVVTLLTLSQPVLTRDVLADIEADRPVGRLVALLIGVLVVVAVLGGVR FT DYLLQRAAEGLVLTARRRLVARLLRLPITEYDQRRTGDMLSRVGADTTMLRAVVTSGLF FT DTVTNVVMVGGSALMMCLIDPTLFAATALGLGLGVLAVVGLSRRVRGASRDAQDRIGEM FT TSAVERAISAVRTIRASGAEEREGKAVDGYAQQAYHAGMRIARLQAMINPITSTTIQVA FT FLVVLGLGGARVASGAIQVGDMVAFVLFLFMLWFPLGRALTAYSRLQSGLGALQRIEEM FT VDLPQETDAVAGPLTVRERTRPGTEPADAEPRPPAIEFEGVSFGYGDGETVLRDVSLAV FT PRGTRTALVGPSGAGKSTLLSLVERFYDVTSGTVRVGGTDVRDLPRRELRGRLGYVEQS FT APVLAGTVRDNLSLAAPDATDDDMREVLRSVNLMGVIERAPQGLDTEVGEGGVLLSGGE FT RQRLALARTFLAAPPIMLLDEATSNLDARNEALMREAIGTVTADRTLLVVAHRLSTVVD FT SDQIVVLEHGRVVAAGRHEELTGTSPLYRELASHQLLIQ" FT /gene="SCO3235" FT /protein_id="CAB38879.1" FT misc_feature complement(66442..66996) FT /note="Pfam match to entry PF00005 ABC_tran, ABC FT transporter, score 184.50, E-value 1.7e-51" FT /gene="SCO3235" FT /gene_synonym="SCE29.04c" FT misc_feature complement(66619..66663) FT /note="PS00211 ABC transporters family signature." FT /gene="SCO3235" FT /gene_synonym="SCE29.04c" FT misc_feature complement(66952..66975) FT /note="PS00017 ATP/GTP-binding site motif A (P-loop)." FT /gene="SCO3235" FT /gene_synonym="SCE29.04c" FT misc_feature complement(67249..68055) FT /note="Pfam match to entry PF00664 ABC_membrane, ABC FT transporter transmembrane region., score 129.80, E-value FT 4.9e-35." FT /gene="SCO3235" FT /gene_synonym="SCE29.04c" FT gene complement(68239..69240) FT /gene="SCO3236" FT /gene_synonym="SCE29.05c" FT CDS complement(68239..69240) FT /product="putative oxygenase" FT /codon_start=1 FT /gene_synonym="SCE29.05c" FT /transl_table=11 FT /note="SCE29.05c, possible oxygenase, len: 333 aa; similar FT to TR:Q05581 (EMBL:L06213) clavaminate synthase I, an FT alpha-ketoglutarate-dependent oxygenase central to the FT biosynthesis of clavulanic acid, a potent inhibitor of FT beta-lactamases (324 aa) fasta scores; opt: 498, z-score: FT 571.8, E(): 1.5e-24, (34.3% identity in 283 aa overlap)." FT /note="smCOG: SMCOG1046:Dioxygenase_TauD/TfdA (Score: 24.4; FT E-value: 7.68e-06);" FT /db_xref="GI:4490983" FT /db_xref="GOA:Q9Z4Z5" FT /db_xref="InterPro:IPR003819" FT /db_xref="InterPro:IPR014503" FT /db_xref="PDB:2OG5" FT /db_xref="PDB:2OG6" FT /db_xref="PDB:2OG7" FT /db_xref="UniProtKB/Swiss-Prot:Q9Z4Z5" FT /translation="MAANAAGPASRYDVTLDQSDAELVEEIAWKLATQATGRPDDAEWV FT EAARNAWHAWPATLRRDLAGFRRDSGPDGAIVLRGLPVDSMGLPPTPRVNGSVQREASL FT GAAVLLMTACGLGDPGAFLPEKNGALVQDVVPVPGMEEFQGNAGSTLLTFHNENAFHEH FT RPDFVMLLCLRADPTGRAGLRTACVRRVLPLLSDSTVDALWAPEFRTAPPPSFQLSGPE FT EAPAPVLLGDRSDPDLRVDLAATEPVTERAAEALRELQAHFDATAVTHRLLPGELAIVD FT NRVTVHGRTEFTPRYDGTDRWLQRTFVLTDLRRSRAMRPADGYVLGAAPQPA" FT /gene="SCO3236" FT /protein_id="CAB38880.1" FT gene complement(69298..70686) FT /gene="SCO3237" FT /gene_synonym="SCE29.06c" FT CDS complement(69298..70686) FT /product="conserved hypothetical protein" FT /codon_start=1 FT /gene_synonym="SCE29.06c" FT /transl_table=11 FT /note="SCE29.06c, unknown, len: 462 aa; similar to FT TR:O69954 (EMBL:AL023862) hypothetical protein from FT Streptomyces coelicolor (465 aa) fasta scores; opt: 2210, FT z-score: 2646.8, E(): 0, (70.8% identity in 452 aa FT overlap)." FT /db_xref="GI:4490984" FT /db_xref="GOA:Q9Z4Z4" FT /db_xref="InterPro:IPR002591" FT /db_xref="InterPro:IPR017849" FT /db_xref="InterPro:IPR017850" FT /db_xref="UniProtKB/TrEMBL:Q9Z4Z4" FT /translation="MLDVVGLTPRLLAHMPRLSALRDAGTGARLDTVLPAVTCSVQSTL FT LTGRPPAEHGVVGNGWYFRDLGEVLLWRQHNRLVGGEKVWQAARALHPGYTVANVCWWY FT AMGADVDWTVTPRPVYYADGRKEPDCYTHPASLHDELTGRLGPFPLFHYWGPTADLASS FT RWIVDAARHLHRAHKPDLNLVYVPHLDYDLQRFGPDSRRARRAAAELDRTLAPLLDEAR FT RDGVTVVVLSEYGITPVSRPVDINRALRRAGLLAVHTQDGMEYLDPWTSRAFAVADHQV FT AHVYVRDAADLPRVEELLHGLDGVAEVLGEAGKKEHGLDHERAGELVAVARPEAWFTYY FT YWLDDARAPDFARTVEIHRKPGYDPAELGFDHHAPAKARLRAAAALARKKLGLRYTMNV FT VPLDGSRVRGSHGRLPGRPEDAPVLLVSDPDAPLGELVAATEVKELLLSLAGISPHAHS FT IRGR" FT /gene="SCO3237" FT /protein_id="CAB38881.1" FT gene complement(70698..71858) FT /gene="SCO3238" FT /gene_synonym="SCE29.07c" FT CDS complement(70698..71858) FT /product="hypothetical protein" FT /codon_start=1 FT /gene_synonym="SCE29.07c" FT /transl_table=11 FT /note="SCE29.07c, unknown, len: 386 aa; similar to FT TR:O69953 (EMBL:AL023862) hypothetical protein from FT Streptomyces coelicolor (391 aa) fasta scores; opt: 1396, FT z-score: 1559.7, E(): 0, (58.6% identity in 389 aa FT overlap). Contains PS00730 AP endonucleases family 2 FT signature 2." FT /db_xref="GI:4490985" FT /db_xref="GOA:Q9Z4Z3" FT /db_xref="InterPro:IPR012307" FT /db_xref="InterPro:IPR013022" FT /db_xref="InterPro:IPR018246" FT /db_xref="UniProtKB/TrEMBL:Q9Z4Z3" FT /translation="MRLRHRDGTTVHLAYCTNVHAAEDLDGVLAQLARYGEPVRERLGA FT DRIGLGLWLAAPVVTALAADRSALDLLRKELDLRGIEVVTLNAFPYAGFHAPTVKKAVY FT RPDWTERPRLDHTLACARVLAELLPPDAARGSVSTLPLAWRTPWTPRRDDLARRHLDLL FT SQGLAALNADTGRTVRVGFEPEPGCLIETTGQAVARLAGADPERLGVCVDTCHLAVAFE FT EPGPALTRLAAALPVVKTQASCAVHADRPADPAARAALAAFAERRFLHQTRQAAPGGPS FT AVDDLPEALGGALNGDAAWRIHYHVPVQRDLPPPLRSTRPELVAALTTLLGGPTALTDH FT VEVETYTWPVLPGAPDGGGLVDGIAGELAWTRSALTALGLTEESTP" FT /gene="SCO3238" FT /protein_id="CAB38882.1" FT misc_feature complement(71211..71234) FT /note="PS00730 AP endonucleases family 2 signature 2." FT /gene="SCO3238" FT /gene_synonym="SCE29.07c" FT gene complement(71865..72734) FT /gene="SCO3239" FT /gene_synonym="SCE29.08c" FT CDS complement(71865..72734) FT /product="conserved hypothetical protein" FT /codon_start=1 FT /gene_synonym="SCE29.08c" FT /transl_table=11 FT /note="SCE29.08c, unknown, len: 289 aa; similar to FT TR:O69952 (EMBL:AL023862) hypothetical protein from FT Streptomyces coelicolor (282 aa) fasta scores; opt: 1391, FT z-score: 1679.9, E(): 0, (72.3% identity in 285 aa FT overlap)." FT /db_xref="GI:4490986" FT /db_xref="GOA:Q9Z4Z2" FT /db_xref="InterPro:IPR001130" FT /db_xref="InterPro:IPR012022" FT /db_xref="UniProtKB/TrEMBL:Q9Z4Z2" FT /translation="MTRIFDPHIHMTSRTTDDYEAMAAAGVRALVEPAFWLGQPRTGVS FT SFTDYFDALLGWEPYRAEQFGIRHHCALALNPKEANDPRLAGVLDVLPDYLVRDRVVAV FT GEVGYDAMTPQEDKAFTVQLELAVRHALPVLVHTPHRDKANGTRRTLDVVRESGIDPGL FT VVVDHLNEVTVRAVADSGCWMGFSIYPDTKMSEDRMVALLREYGTARILVNSAADWGRS FT DPLKTRRTADAMRAAGFGEDDVDQVLWRNPVAFYGQSGRLELDGPEGAEASGVRAEFEG FT SSIRRGER" FT /gene="SCO3239" FT /protein_id="CAB38883.1" FT gene complement(72731..73441) FT /gene="SCO3240" FT /gene_synonym="SCE29.09c" FT CDS complement(72731..73441) FT /product="conserved hypothetical protein" FT /codon_start=1 FT /gene_synonym="SCE29.09c" FT /transl_table=11 FT /note="SCE29.09c, unknown, len: 236 aa; similar to FT TR:O69951 (EMBL:AL023862) hypothetical protein from FT Streptomyces coelicolor (245 aa) fasta scores; opt: 416, FT z-score: 464.9, E(): 1.4e-18, (45.5% identity in 220 aa FT overlap)." FT /db_xref="GI:4490987" FT /db_xref="UniProtKB/TrEMBL:Q9Z4Z1" FT /translation="MNPGGDGPRSLPDALAGALDRALAPDAAAWLEQACAAVRCEPGEV FT EGTFAVAARRCGRGALDAGAEAGAGADAGTGLGAGWSVDDAARVLLLAALPVRGAALAA FT VVSRLYRIGGGPERRAVLRSLSLLEAAGDLGDLGLPLVEDALRCNDPRLIAAAVGPYGA FT RRLGAHAFRQAVLKCVFVGVPLDLVAALDARADAELDRMMADFAAERRAAGRALPPDVA FT AYLHTHRVSTEATA" FT /gene="SCO3240" FT /protein_id="CAB38884.1" FT gene complement(73438..74310) FT /gene="SCO3241" FT /gene_synonym="SCE29.10c" FT CDS complement(73438..74310) FT /product="putaive isomerase" FT /codon_start=1 FT /gene_synonym="SCE29.10c" FT /transl_table=11 FT /note="SCE29.10c, possible isomerase, len: 290 aa; similar FT to TR:O69950 (EMBL:AL023862) hypothetical protein from FT Streptomyces coelicolor (315 aa) fasta scores; opt: 1116, FT z-score: 1331.4, E(): 0, (62.5% identity in 283 aa FT overlap). Also similar to SW:XYLA_STRDI xylose isomerase FT from Streptomyces diastaticus (388 aa) fasta scores; opt: FT 122, z-score: 148.8, E(): 0.56,25.0% identity in 296 aa FT overlap." FT /db_xref="GI:4490988" FT /db_xref="GOA:Q9Z4Z0" FT /db_xref="InterPro:IPR012307" FT /db_xref="InterPro:IPR013022" FT /db_xref="UniProtKB/TrEMBL:Q9Z4Z0" FT /translation="MSAGTRFGYGTNGFGDHPLEDALAVLADLGYEGVGLTLDPRHLDP FT FADDLPHRLRRLAARLDRLGLAVVVETGGRYVLDPWRKHQPVLMSAEGAGRRVDLLLRA FT VRIAADLGAEAVSFWSGAAPADTPRQVVWDRLLAGCGTVVEAAARAGVVLGFEPEPGMF FT VDTLDAYDELCRRLGGPHPLGLTLDIGHCRCLEPQPVADCVRRVADRLVNVQIEDMRRG FT THEHLEFGSGEIDFPPVLSALAATGYRGLVSVELPRHSHAAPEVARRSLDFLRAADAGA FT RPATRGAAA" FT /gene="SCO3241" FT /protein_id="CAB38885.1" FT gene complement(74307..75182) FT /gene="SCO3242" FT /gene_synonym="SCE29.11c" FT CDS complement(74307..75182) FT /product="puitative transferase" FT /codon_start=1 FT /gene_synonym="SCE29.11c" FT /transl_table=11 FT /note="SCE29.11c, possible transferase, len: 291 aa; FT similar to TR:O69949 (EMBL:AL023862) hypothetical protein FT from Streptomyces coelicolor (363 aa) fasta scores; opt: FT 666, z-score: 682.9, E(): 9.9e-31, (51.3% identity in 312 FT aa overlap). Also similar to SW:UBIA_ECOLI FT 4-hydroxybenzoate octaprenyl transferase from Escherichia FT coli (290 aa) fasta scores; opt: 137, z-score: 150.2, E(): FT 0.47, (31.8% identity in 110 aa overlap)." FT /db_xref="GI:4490989" FT /db_xref="GOA:Q9Z4Y9" FT /db_xref="InterPro:IPR000537" FT /db_xref="UniProtKB/TrEMBL:Q9Z4Y9" FT /translation="MSALPRVHDLARLVRAPAALSVPGDVLAGAAAARRPLGPGLLGMT FT ASSVCLYWAGMALNDYADRDLDAVERPERPVPSGAVSPAAARAVGCGLTAAGLGLAALS FT RGRRGLATALPLAGVVWAYDLVLKPTPAGAAAMAAARALNVLGGAGPGGLRRALPAAAT FT VALHTGMVTRLSRYEVSGAPRAVPRQSLAVGGAVGAAVLLRGRRRPARDRVLAAGLTAV FT YAYGGAAAQLAAARSPAAPQVRRAVAAGIHALIPLQAALTATAGRGAAGAALACALPWA FT RRLGRKVSPT" FT /gene="SCO3242" FT /protein_id="CAB38886.1" FT gene complement(75179..76345) FT /gene="SCO3243" FT /gene_synonym="SCE29.12c" FT CDS complement(75179..76345) FT /product="putative myo-inositol phosphate synthase" FT /codon_start=1 FT /gene_synonym="SCE29.12c" FT /transl_table=11 FT /note="SCE29.12c, possible myo-inositol phosphate synthase, FT len: 388 aa; similar to many e.g. TR:O69948 (EMBL:AL023862) FT from Streptomyces coelicolor (417 aa) fasta scores; opt: FT 955, z-score: 1034.1, E(): 0, (60.3% identity in 380 aa FT overlap) and SW:INO1_CITPA myo-inositol phosphate synthase FT from Citrus paradisi (grapefruit) fasta scores; opt: 323, FT z-score: 352.1, E(): 2.6e-12, (26.9% identity in 364 aa FT overlap)." FT /db_xref="GI:4490990" FT /db_xref="GOA:Q9Z4Y8" FT /db_xref="InterPro:IPR002587" FT /db_xref="InterPro:IPR013021" FT /db_xref="InterPro:IPR016040" FT /db_xref="UniProtKB/TrEMBL:Q9Z4Y8" FT /translation="MRTGIWLVGARGSVATTTVVGAAALRAGLVPATGCVSALEAFDGV FT PLPGFDELVFGGHDVVGTGLVKRAEQLAEAGVVPRGLPGVLTAELDAADAEIRPAPPGT FT EEGGDGTPDQASAAGAIVADLTGFRERLGLDRVVVVNVSSTQPPAVPHPAHASAAALRE FT ALARGERPLPVSSLYAYAALRAGCAFVDFTPSTGARLPALDELAREQGLPYAGSDGKTG FT ETLVKSVLAPMFARRALRVRSWSGTNLLGGGDGATLADPERVVSKNASKGLVLEAELGH FT AVEGGVHIHHVPDLGEWKTAWDHVTFEGFLGARMTLQFTWQGCDSSLAAPLVLDLARFM FT ALAHRAGVAGPVPELGFFFKDPVGSAEHDLAAQYASLAAWARSVGAPA" FT /gene="SCO3243" FT /protein_id="CAB38887.1" FT gene complement(76395..77192) FT /gene="SCO3244" FT /gene_synonym="SCE29.13c" FT CDS complement(76395..77192) FT /product="putative secreted protein" FT /codon_start=1 FT /gene_synonym="SCE29.13c" FT /transl_table=11 FT /note="SCE29.13c, putative secreted protein, len: 265 aa; FT similar to SW:Y0BO_MYCTU hypothetical protein from FT Mycobacterium tuberculosis (529 aa) fasta scores; opt: 116, FT z-score: 133.8, E(): 3.8, (38.2% identity in 76 aa FT overlap). Contains possible N-terminal region signal FT peptide sequence" FT /db_xref="GI:4490991" FT /db_xref="InterPro:IPR006311" FT /db_xref="UniProtKB/TrEMBL:Q9Z4Y7" FT /translation="MSNHLDRRRLMTTALGGAAAVGLGAGAGLLGAAPAGAAERPVTPH FT RGHDDFPDVPGMLGDRRANELWYMFDETTLYNVGPELEQAFTDIETALGDGWERAIFDA FT WMAMAATSDYPNNFIEYVTPIKGPLQVLSKAQLGVFDTYYRPYGHGIVGAFADFAQGVL FT NDPRRERPVHTMNGNPPPGYHIWFIFMRSMMLLDISRHRWERMAPINAMAWAIQTIAKP FT SQFEVKEPLPRRVVAREAAKWLPRSVHRLDRDFLSYPLPEGMS" FT /gene="SCO3244" FT /protein_id="CAB38888.1" FT gene complement(77260..78522) FT /gene="SCO3245" FT /gene_synonym="SCE29.14c" FT CDS complement(77260..78522) FT /product="putative salicylate hydroxylase (putative FT secreted protein)" FT /codon_start=1 FT /gene_synonym="SCE29.14c" FT /transl_table=11 FT /note="SCE29.14c, possible salicylate hydroxylase (putative FT secreted protein), len: 420 aa; similar to many e.g. FT TR:P96555 (EMBL:AB000564) salicylate hydroxylase from FT Sphingomonas sp. AJ1 (395 aa) fasta scores; opt: 830, FT z-score: 827.2, E(): 0, (41.9% identity in 320 aa overlap) FT and TR:G4104775 (EMBL:AF039534) salicylate hydroxylase from FT Pseudomonas stutzeri strain AN10 (389 aa) fasta scores; FT opt: 707, z-score: 706.0, E(): 5.1e-32, (34.7% identity in FT 401 aa overlap). Contains Pfam match to entry PF01360 FT Monooxygenase, Monooxygenase, score 91.00, E-value 2.4e-23. FT Contains possible N-terminal region signal peptide FT sequence" FT /note="smCOG: SMCOG1087:hypothetical_protein (Score: 375.6; FT E-value: 5.2e-114);" FT /db_xref="GI:4490992" FT /db_xref="GOA:Q9Z4Y6" FT /db_xref="InterPro:IPR002938" FT /db_xref="InterPro:IPR003042" FT /db_xref="UniProtKB/TrEMBL:Q9Z4Y6" FT /translation="MPKLRIAVVGGGIGGLAAALALTRKGHEVRVYEQAPELREAGVGM FT HLGPNGSRLLERWGLGERLRALGVRPAGMEVRDWSHGGTLVRQPMGEEWLAEFGAPYYT FT IHRADLHTMLAESLPSGTVRAGHRLERFTETGGGVRLEFADGSTAGADVLIGADGAHSV FT VRRTLAGPDTAVFSGQSAFRGVVARDQVPGLPGDTLLVWAGPDARMLVYPVRGGRFLTF FT VAVVPDPRWRLESWSAPGDLDELAARFDGWNTDVKSLVAAVRESRRWALYDREPLARWS FT AGAVTLLGDAAHPMLPHHGQGVSQAVEDAAVLAHCLDAPTGPDPSASVSAAAAASAPAA FT AAASAPAARRAIAAALDAYEGVRRPHTTRVQLGSRGGGSQRLRPDEDGTESTGTMSSLV FT EDVSWIQRHDAEAGLPPLPPP" FT /gene="SCO3245" FT /protein_id="CAB38889.1" FT misc_feature complement(77398..78075) FT /note="Pfam match to entry PF01360 Monooxygenase, FT Monooxygenase, score 91.00, E-value 2.4e-23." FT /gene="SCO3245" FT /gene_synonym="SCE29.14c" FT gene complement(78569..79561) FT /gene="SCO3246" FT /gene_synonym="fabH4" FT /gene_synonym="SCE29.15c" FT CDS complement(78569..79561) FT /product="putative 3-oxoacyl-[acyl carrier protein] FT synthase III" FT /codon_start=1 FT /gene_synonym="fabH4" FT /gene_synonym="SCE29.15c" FT /transl_table=11 FT /note="SCE29.15c, fabH4, probable 3-oxoacyl-[acyl carrier FT protein] synthase III, len: aa; similar to many eg. FT SW:FABH_ECOLI 3-oxoacyl-[acyl carrier protein] synthase FT III, FabH, from Escherichia coli (317 aa) fasta scores; FT opt: 765, z-score: 862.6, E(): 0, (40.8% identity in 314 aa FT overlap). Also similar to two from Streptomyces coelicolor FT - TR:O54151 (EMBL:AL021409) (335 aa) fasta scores; opt: FT 694, z-score: 782.9, E(): 0, (53.5% identity in 331 aa FT overlap) and TR:E1359140 (EMBL:AL034443) (316 aa) fasta FT scores; opt: 685, z-score: 773.2, E(): 0, (40.6% identity FT in 313 aa overlap)." FT /note="smCOG: FT SMCOG1084:3-oxoacyl-(acyl_carrier_protein)_synthase_III FT (Score: 355.8; E-value: 3.2e-108);" FT /db_xref="GI:4490993" FT /db_xref="GOA:Q9Z4Y5" FT /db_xref="InterPro:IPR004655" FT /db_xref="InterPro:IPR013747" FT /db_xref="InterPro:IPR013751" FT /db_xref="InterPro:IPR016038" FT /db_xref="InterPro:IPR016039" FT /db_xref="UniProtKB/Swiss-Prot:Q9Z4Y5" FT /translation="MSAARGGRAGAVVTGVGTCLPETVVDNDEVSRHLDTDHAWIHSRT FT GIERRRRVSPGTTTGDLAVTAGAAALKSAGRDDCDLVLLATTTPDRRCPATAPRVASRL FT GLRAAAAFDLSAVCSGFVYGLSVASAMITAGTCDRALVIGADVYSSIVDPDDRGTAVVF FT GDGAGAVLLERGDTGDPGAVLHTELGSDGTGDELITIPPDGAYLTMRGSDVYTRAVTTM FT AESARSTAAHAGWDLADVDAFVGHQANLRILTSVAKRLRLPPERVVSNIADVANTAAAS FT IPLALADAAAQGRIGSGDRLLLTAFGGGLTWGSAAVVWSGAEPVQDQRS" FT /gene="SCO3246" FT /protein_id="CAB38890.1" FT gene complement(79558..81360) FT /gene="SCO3247" FT /gene_synonym="SCE29.16c" FT CDS complement(79558..81360) FT /product="putative acyl CoA oxidase" FT /codon_start=1 FT /gene_synonym="SCE29.16c" FT /transl_table=11 FT /note="SCE29.16c, possible acyl CoA oxidase, len: 600 aa; FT similar to many acyl CoA oxidases, especially from FT eukaryotes e.g. SW:CAOP_RAT acyl CoA oxidase from Rattus FT norvegicus (rat) (661 aa) fasta scores; opt: 462, z-score: FT 477.6, E(): 2.7e-19, (27.8% identity in 425 aa overlap). FT Contains PS00017 ATP/GTP-binding site motif A (P-loop)." FT /note="smCOG: SMCOG1006:acyl-CoA_dehydrogenase (Score: FT 133.0; E-value: 1.56e-39);" FT /db_xref="GI:4490994" FT /db_xref="GOA:Q9Z4Y4" FT /db_xref="InterPro:IPR006090" FT /db_xref="InterPro:IPR006091" FT /db_xref="InterPro:IPR009075" FT /db_xref="InterPro:IPR009100" FT /db_xref="InterPro:IPR012258" FT /db_xref="UniProtKB/TrEMBL:Q9Z4Y4" FT /translation="MTQREEELARVLSGPEFATIRPDDLSVLDYSLLTLRRARLLNGAG FT FAANSLWLGRGDSARFPEFLRTMGWIGAYDLSLLNVLVSHQIAGDALLSHGGPEQLDAW FT AGEIDAMERMYCFAGSELLAGSDLKRVRTTAVYDPHGRSLVLNTPRPADSKVWTGNSLH FT TGDVAMVLARLEVGGRDEGHHWLRVPLREAGAVLPGVRIGRAEPKGGVTANQTGVLTFT FT DHRLPLSALMNRWASIDEDGTYRSPLPRHRRFEECLATFTHERLFPSVGAAYAQLLACT FT ITTRFAAVKQTFGRPLIGHEHYRMRLSAAVGRSLAARHAMTALAEVAVARSAEGAPARD FT QVLHALISCGKSGCTGDARQTLAETRELCGGLGYHDANQIAPLLHDYEIAVTFGGDNTV FT LGYQATRFALRHREDFDRVLDEAVAGAGRLDAVRVLRAVCDVLLDRVERDGAGEASAQW FT SRAVHQTLAIGHWARQASTPLSERLLAQYAAVCVLEHALAALRAGILDQDALLGFEAAR FT HEAAGAPLDADALLRELAVPEGLISAPIAHPDFAERHAAAAHAGTAAAHAGTVPSPGTG FT PSPGTGPAPGTVQAPGTVQAGVRP" FT /gene="SCO3247" FT /protein_id="CAB38891.1" FT misc_feature complement(80305..80328) FT /note="PS00017 ATP/GTP-binding site motif A (P-loop)." FT /gene="SCO3247" FT /gene_synonym="SCE29.16c" FT gene complement(81410..82630) FT /gene="SCO3248" FT /gene_synonym="fabF3" FT /gene_synonym="SCE29.17c" FT CDS complement(81410..82630) FT /product="putative 3-oxoacyl-[acyl carrier protein] FT synthase II" FT /codon_start=1 FT /gene_synonym="fabF3" FT /gene_synonym="SCE29.17c" FT /transl_table=11 FT /note="SCE29.17c, fabF3, probable 3-oxoacyl-[acyl carrier FT protein] synthase II, len: 406 aa; similar to many e.g. FT TR:O54149 (EMBL:AL021409) 3-oxoacyl acyl carrier protein FT synthase II from the Red cluster of Streptomyces coelicolor FT (407 aa) fasta scores; opt: 1217, z-score: 1314.2, E(): 0, FT (50.1% identity in 407 aa overlap) and SW:FABF_ECOLI FT 3-oxoacyl-[acyl carrier protein] synthase II FabF, from FT Escherichia coli (412 aa) fasta scores; opt: 843, z-score: FT 912.2, E(): 0, (35.4% identity in 404 aa overlap). Contains FT Pfam match to entry PF00109 ketoacyl-synt, Beta-ketoacyl FT synthase, score 92.60, E-value 7.7e-24 and Prosite match FT PS00606 Beta-ketoacyl synthases active site." FT /note="smCOG: SMCOG1022:Beta-ketoacyl_synthase (Score: FT 348.8; E-value: 7.6e-106);" FT /db_xref="GI:4490995" FT /db_xref="GOA:Q9Z4Y3" FT /db_xref="HSSP:1E5M" FT /db_xref="InterPro:IPR000794" FT /db_xref="InterPro:IPR014030" FT /db_xref="InterPro:IPR014031" FT /db_xref="InterPro:IPR016038" FT /db_xref="InterPro:IPR016039" FT /db_xref="UniProtKB/TrEMBL:Q9Z4Y3" FT /sec_met="NRPS/PKS subtype: PKS/NRPS-like protein" FT /sec_met="NRPS/PKS Domain: PKS_KS (65-404). E-value: FT 6.6e-52. Score: 168.1;" FT /translation="MTEGPAAITGVGLVTPAGTDADSTWEAMCAARSLEGGDPEPLAGT FT GAWHSLRVPALRPGQLTGRGTARTDPFIRFALVAVAEALAQSGLDPDSWDGSRVGVVVG FT SAFGGVTTHDEQHRRLERQGAAMVSPYLHPRALINMAAGTIGARYGITGPGHTVAAACA FT SGASAFGLGKTLLDAGVCDTVVVCGTDAAVTPLVVSGFARMGALSEQKATDASRPFGAD FT RDGFVMSEGAAAVVMEKPAKARARGAEVLGRLLGHADTSDAHHPTAPRPDGAGAAAAVE FT RALAAARMSVRNVTTVNAHGTSTPQNDLTEARLIARLFPHGPSVTANKGLLGHTLGAAG FT AIEAVLTLRSLRTGVLPPIAHTERADPGLPELDLVLGGVRRHDGNVAVSTSFGFGGSNC FT ALVLDAG" FT /gene="SCO3248" FT /protein_id="CAB38892.1" FT misc_feature complement(81413..82615) FT /note="Pfam match to entry PF00109 ketoacyl-synt, FT Beta-ketoacyl synthase, score 92.60, E-value 7.7e-24." FT /gene="SCO3248" FT /gene_synonym="fabF3" FT /gene_synonym="SCE29.17c" FT misc_feature complement(82124..82174) FT /note="PS00606 Beta-ketoacyl synthases active site." FT /gene="SCO3248" FT /gene_synonym="fabF3" FT /gene_synonym="SCE29.17c" FT gene complement(82627..82872) FT /gene="SCO3249" FT /gene_synonym="SCE29.18c" FT CDS complement(82627..82872) FT /product="putative acyl carrier protein" FT /codon_start=1 FT /gene_synonym="SCE29.18c" FT /transl_table=11 FT /note="SCE29.18c, probable acyl carrier protein, len: 81 FT aa; member of a large family including SW:ACP_HELPY acyl FT carrier protein from Helicobacter pylori (78 aa) fasta FT scores; opt: 121, z-score: 179.0, E(): 0.012, (37.5% FT identity in 64 aa overlap). Contains Pfam match to entry FT PF00550 pp-binding, Phosphopantetheine attachment site, FT score 31.20, E-value 5.3e-07." FT /db_xref="GI:4490996" FT /db_xref="GOA:Q9Z4Y2" FT /db_xref="InterPro:IPR006163" FT /db_xref="InterPro:IPR009081" FT /db_xref="UniProtKB/TrEMBL:Q9Z4Y2" FT /sec_met="NRPS/PKS subtype: PKS/NRPS-like protein" FT /sec_met="NRPS/PKS Domain: ACP (7-56). E-value: 4.7e-09. FT Score: 27.8;" FT /translation="MSTDPKSVVHGILAEDLEVDPAEITDGASLRNLELDSLAVAELIV FT RIKEETGVDLSGDETRIADLTVGEVVLLAGSGLEAA" FT /gene="SCO3249" FT /protein_id="CAB38893.1" FT misc_feature complement(82696..82854) FT /note="Pfam match to entry PF00550 pp-binding, FT Phosphopantetheine attachment site, score 31.20, E-value FT 5.3e-07." FT /gene="SCO3249" FT /gene_synonym="SCE29.18c" SQ Sequence 82872 BP; 10726 A; 31202 C; 30262 G; 10682 T; 0 other; tcacgcaccg ccgcgcagct cacgcagcaa ccgggcgact ccgaaggcga gttcgatcga 60 ctgggcggcg ttcagccggg gatcgcaggc cgtctcgtac cggctggcca ggtgggtgtc 120 cagcacctcg tcgaggtcgc cgccgaggca ctcggtgacg tcgtcgccgg tgagttcgag 180 atggatgccg cccgggtgca ggccctcctc gcggtgcacc gcgaagaact cggccacctc 240 ggtcgtgatg tccgagagcc ggcgggtctt gtagccgctc gcggagacga aggtgttccc 300 gtgcatgggg tcgcaggccc acaccggggc gtgtccggcg tcccgcacgg cccgcagcag 360 cggcggcagc agctccgcgc cgcgcccggc gccgagcctg ctgatcagga cgagccggcc 420 cggcgcccgg tcggggtcca gccgctcgca cagttcccgc aggtcgtcga cgcccatggt 480 gggccccacc ttgacgccga ccgggttgtc caccccggcg agcagttcca cgtgcgcgcc 540 gtcgacgcgg cgggtgcggt cgccgatcca cagcaggtgc gcactggtgt cgaaccagcc 600 ccgccgcttc tcgtcgtacc ggatcagcgc ctgctcgtac tgcggcagca gcgcctcgtg 660 cgaggtgtag agctggacct ggtgcagggc ggcctgggag cgggtgtcca ggccgcaggc 720 ggacatgaac ctgagggccc aggtgatgtc gtcggcggcc ttctcgtacc gctgtccggc 780 ggggctgcgc cggacgaact cctggttcca ttcgtggacc tggcccaggt cggcgtagcc 840 gcccagggtc agcgcccgca gcacgttcag ggccgccgag gcgtggtggt aggcgctcag 900 cagccggccg gcgtccgggc ggcgggcctc ggcggtgaac tcggggccgt tgacgatgtc 960 cccgcggtag acgggcagtt cgacgccgtc gacggcctcc gtggggcggc tgcggggctt 1020 gccgaactgg ccggcgatcc tgcccacctt caccaccggc agcccggagc cgtaggtgag 1080 caggatggcc acctggagga tgacccgcag cttgccgcgc acccctgcct cggtgcagga 1140 cccgaaccgc tccgcgcagt cgcccgcctg gagcaggaag ccctcccccg cggcgacctg 1200 ggccagggag cggcgcaggt cgaggatctc gtcgggcagc accaggggcg gcctgagcgc 1260 gagggtgtcc tccacgccgc gcagttcccc ggggtcgggc cactcaggct gctgcgcggc 1320 cggccggctc cgccacgagc cgggggtcca tccgccccgc ccggcgtcgg ccgcggggcc 1380 ggtcgggccc ggggccgcgg tgccggtccc ggccggggcc gtgcggggtt gcgtgtacgt 1440 gtcgctcgcc gtcatccgac cagtcccttg atcgtggtac cggggtcacc ggcccgcatg 1500 agcagttctc cgaccaggac cgcgtccacc ccggccgctt ccagcgcgcg ggcgtcgggt 1560 gcgccgcgca cgccgctctc cccgaccatg acccgcccgg tgccgacccg cccccgcagc 1620 cgggccgaaa gggtccggtc gatcgagaag tcccgcaggt cgcggtggtt gacgccgatc 1680 acgtcggcgc ccgcctccag ggccacgtcc acttcccgtt cgtcgtgcac ctcgaccagc 1740 gcctccatgc cgcaggcacg ggtgcgggcc aggagtgcgg cgagccgtgc gggggcgagc 1800 gcggcgacga tcagcagcag ggcgtcggcg ccgagcgccc gggcctccag gatctggtac 1860 tcgtcgacga cgaagtcctt gcgcaggacg gggagttcgc aggccgcgcg ggcgacggcc 1920 aggtggtccg ggctgccgcc gaagcccgcc tcgtgggtga gcaccgacac ggcgtgggcg 1980 ccgccgccct gataggcgcg ggccagttcg gccggccggt agtcgtcggt gagcggcccc 2040 ttggaggggc tgcggggctt catctcggcg atgaccgcga gcccgggttc gcgcagcgcg 2100 gcggcgaagt cccgggccgg gggcgccgcg gcggccagct cggtcagctt cgcctcggtg 2160 cgcagcgcgc gccggcgccc ggtctgcgac tcggcctcgg cgacgaggcc ggcgaggatg 2220 ccgctcatgc cggcacctcc accaggtccg cccgctgcca ggaggcgtgg gcccagcggt 2280 cgagcaggcc ggcggcggcg cccccgtcga cggcggacgc tgccagccgc agcccgtcgg 2340 accaggtgcc ggccacgccg gcgacccgca gcgccgcggc ggcgttgagc aggacgacgt 2400 cccgcgcggg tccgcgcccg ccggccagga cacggcgcag gacggccgcg ttgacggcgc 2460 ggtcgccgcc cgccaggtcg ccggggcggg accgggccag gccgtgctcg gcggggtcga 2520 agcggtgggt ggtgcgccgt ccgtcgcgca gttcgaccag gtgggcgggg gcggcggtgc 2580 tcagttcgtc catgccgtcc gcgctgtgga aaaccagggc gcgggtgacg ccgagtcgtt 2640 cgaggacctc ggtcatcggt tccaccagct cgcggctcgg cacccccagg gtgcgcagcc 2700 gggcgcccga ggggttgcac aggggtccca gcaggttgaa gacggtccgc gcgcccagtt 2760 cccggcgcgg tcccgccgtg tgccggaagg ccgggtggaa gaccggggcg aacaggaagg 2820 tgatcccggt gcggtccagg caggcggcgg cctcctcggc gccgaggtcg atgcggacgc 2880 ccagttcctc cagcacgtcg gcgctgccgc aggcggagga cgcgctgcgg ttgccgtgct 2940 tggcgacccg taccccgcag gcggcggcga cgatcgcggc ggcggtggag atgttgaagg 3000 tgttcagccc gtcgccgccg gtcccgcagg tgtcgagcag atcgccgccc gcgcgcggga 3060 ccggggtggc gaactcctgg gcggcgcggg ccatgccggc caggttgtcg gcggaggcgc 3120 cgcggaccgt gacggccagt gcgaaggcgg cgatctgggc ggccgtggcc tcgccgcgca 3180 tgatcacgcg catcgcgtcg gccgcctcgg cctcggtgag gggccgttgc acgagcgttc 3240 tcagtgactc aatcatcggc gcactccagg aagttcgcga tcagctgctt gccctcgggg 3300 ctgagcaccg actcggggtg gaactgcacc ccgtggaccg ggtgcgtgcg gtggcgcagg 3360 cccatgaccg tgccgtccgc ggtgcgggcg gtgacggtca gctcgtccgg caggccggcg 3420 ggctcgacca cgagcgagtg gtagcgggtg gcgctgaacg ggtcgggcag gccggcgaac 3480 accccgccgc cgtcgtggtg cacggcactg gccttgccgt gcacctgctc gccgcgcacc 3540 accgagccgc cgtaggcgac ggcgacggcc tggtggccca ggcacacgcc gaggacgggc 3600 agccgtgcgc cgagtgcgcg gaccgcgtcc acgcagatgc cggcgccggc gggggtgccg 3660 gggcccggcg agagcagcag caggtcgaat ccggcgagtt cggcgacggt gacggcgtcg 3720 ttgcggaaca ccgtggggcg gccgcccagt tcggcgacgt agtggacgag gttgtaggtg 3780 aacgagtcgt agttgtcgat caccgcgacc cgtggcgccg cgcccgcgcg ggtgccggtg 3840 ggggcgctca tgccgccgcc tccgcccgcc gtacggccgt gagcatggcg cgcgacttgt 3900 gcagggtctc gcggaactcg gccgcggggt cggagtcggc gacgatcccg gcgcccgcct 3960 gcacgtgcac gtggccgtcg gcgacgacca tggtgcgcag ggcgatggcg aagtcggtca 4020 gaccgtccgc gccgacgaag ccgagggcgc cgccgtacac cccgcgctgc tcgggctcca 4080 gctcggcgat gatctccatg gcccggatct tgggcgcccc ggagagcgtt ccggcgggga 4140 aggccgagcg cagggcgtcc agcgcgtccc ggccctcggc gagccgtccg cgcacggtgg 4200 acgacaggtg catcacgtgg gagaagcgct cgacccgcat cagccgctcc acccggaccg 4260 tgcccggctc ggtgacccgg cccaggtcgt tgcgaccgag gtcgaccagc atgacgtgtt 4320 cggcgcgttc cttctcgtcg gcgcgcagct cccgctccag ccgcaggtcc tcggcggggt 4380 cggggtggcg gggccgggtg cccgcgaggg gccgggtgcg caccgtccgg ccctccgcct 4440 tgacgagcag ctcgggcgag gcgccgatca cgtgccggcc tcctcccagg ctcaggtggt 4500 acatgtacgg cgaggggttg gtggcccgca ggtgccggta caggtcggtc ggccgggcgc 4560 gcagcggcct gctgagccgc cgggagagca cgatctggaa ggcgtcaccg gccgcgatgt 4620 gctcccgggc gcgggcgacc cgctcggtga actgtgcctc ggtgaggttc gcggtccagc 4680 cctgcgtccc gtggtcggcc ggcgtggcgg cggcgagcgg gcggccggag aaggcggcgg 4740 gtgccggcgc gcggcgcagg gcgcggttga ggcgcacgat gcgggcgacg gcgtcgtcgt 4800 aggactcgcg ggccgggcgg tagagggtca tcagcaggac gcgccgggtc gcgtggtcga 4860 agacgacgag gtcgtcggcg gcgaggaagg cggactcggg cagtccgggc ggcggtccgg 4920 cggccagggg caggtcctcg aagtggcggg ccgcctcgta cccgaggtag ccgacgacgc 4980 cgccgtggaa cggcggcagt ccgggcaccg gcgccacgga ccgggccagg tgggaccgca 5040 gcgcggtcag cgggtcgccg ccggtcggct cgagcggcac cggtcggtga ccgacgtacg 5100 agtaccgtgc cacgccgccg gagaccggca cgctctccag caggaagccc gcctcgtccg 5160 gtccgcacag ctgggcgaag gcggtgacgg ggctgaccga gtcgtccagg aactcctggt 5220 ggagcgggac gacgtcgtgc tcgcgggcga gtgccgcggc ggcggcgcgg tgcgggacgg 5280 tggcgcgggc ggcctcctcg gcctccgtcg cgtccggagt cttctgtgag cccggtgcgc 5340 cctgtgggtc cgtcgtgggc gcctcggcgg cgtgggtggt catgccgcct tcccggcggt 5400 ggccgagacc cggcccactc cgacgacggc acgccgcgga atggtgacgc gccacccgcc 5460 ggtgccctcc tggcgcagtt cgctcgaggc gaggccgccc tcggcgtccg ggtagcggaa 5520 gacggccttg gcggtctcgg cgacccagcg gtacgcctcc tgctcggtgc gcccctcgaa 5580 gaccttgacc aggccgtaca tgttcagcag gtaccggccg atctccagct ccgcctcctc 5640 gggggtggcg gcgaccgcgg tgtaggggtc gtcgatctcc acgacctcgc ggtggtcgta 5700 gccggccttc tccaggtatc cctcgatctc gtcccgggtg aagtgcagga acttgtggcc 5760 ggtcgccgag tacacgtcgg tgacctcctc gaaccacacg tccacgggcg agccgacgag 5820 gaagtcgtgc aggacgaacg tgccgccggg gcggagcatc cggcgggcct cggtggccac 5880 cgtctgccgg tccgaggacg gcacgtggtg cgagccgtag gccagcagta cggcgtcgac 5940 gctgtggtcg cgcagcagcg gctgctcggc ccgctggagc agggcgggca cgccggccgc 6000 ccacgccgtg gtcaccatgt ggggggacgc gtcgcaggtg aggatgttga agtcgccgat 6060 gcccagctcc tcgcagacct tgcgcaccag tccgtcgccg ccgagcaggt cgaccaggac 6120 gggccggtcg ccggccgcgg tgcggcgggc ggtctcggcg aagccgagga gcttcctgat 6180 ccccgtctcg cgggcgcgcc ggttgagggc ctgggcctgt acgtactcca cgccccggct 6240 gccctcgccg tcggcgccga agtcgtcgtg ccgcccgggg gcgctgcccc tggccgcctc 6300 ccaggcggcg atccgccggg ggtcggccag ggcgtgcagc tcggggtggc tccgccgcag 6360 ttccgccagc tgcccctgca cgtcgtcccc ggtcacggtg ggtccgctcg tctgtgcgcg 6420 catgcgtcgg gatctcctcg ggtgggggtg gacgcgggca agacgatgcc cgccgggcct 6480 gcccgcacga cggtaggagc gtcaactttc tcctcgatat cgattggttt tcgccccgcc 6540 cggccaagat ccgtccctgt cgaaagtaag gcccaagaga cgtcgttcgt gcctggtgac 6600 ggcggatgac gggctcctac agtcacttcg cgggggacgc agccgagacc ggaactgagc 6660 gcggagtcga gcccggaggg cgtcagggat gaagaaccag ttggacgagc cggggggcgc 6720 ggtccgcgtc ggcgggggtg gcggcctgag cgcggcggag gtcgccgaac gggtcgcggc 6780 ggggcaggtc aacgacgtac cggcgcggtc gagccgcacg atcggggaga tcgtccgcag 6840 caacctgttc acccgcatca acgcgatcat cggcgtgctg ttcgtcatcg tgatgatcgt 6900 cgggccggtg caggacggtc tgttcggcgg cgtcatcctc gccaacaccg cgatcggcat 6960 catccaggag gtgcgcgcca agcggaccct ggaccagctg gcgatcgtcg gcgagagccg 7020 gccgcgggtg tggcgggacg ggcagcggct ggaactcagc gcctccgaga tcgtcatcga 7080 cgactccatc gacctcggtc agggcgacaa gatcgtggtg gacggcaccg tcacctcggg 7140 cgacagcctg gaggtcgacg agtcgctgct caccggcgag gccgacccgg tggtcaagca 7200 gcccggcgac ccggtgatgt ccggcagttt cgtggtggcc ggctcgggga cgttcaccgc 7260 cacccgggtg ggcaaggagg cgtacgcctc gcagctcgcc gacgaggcgc ggcgcttcag 7320 cctcgtcaac tccgagctgc gcaacggcat cgaccggatc ctgaagttcg tcacctacgc 7380 gatcgtcccg gcgggcatcg cgctgatcat cacccagttc gtggtgaacg acgacaactt 7440 ctcggaggcg atccggcgca tggtgggcgg tctcgtcccc atggtgcccg agggcctggt 7500 gctgctgacc tcgctggcct tcgcggtcgg cgtggtccgg ctcggcaaga agcagtgcct 7560 cgtgcaggag ctgcccgcca tcgaggggct ggcgcgggtg gacacggtct gcctggacaa 7620 gacgggcacg ctcaccgagg cgtcgatgga cgtcgacgag gtccttccgc tgctgccgga 7680 gctgccggtc gacgcggtgc tcggtgccct gggcgccgcc gacgagcggc ccaacgccag 7740 cctccaggcg atcatcgagt cgtaccccgc ccccgagggc tggcggcgca ccgccaccgc 7800 gccgttctcg tccgcccggc gctggagcgg cgcctccttc gccgagccct ccggcacgga 7860 gtcggcgtgg ctgctggggg caccggacac gatgctgccg gccgggcact cggtgctcac 7920 cgccgccgac tcctacgggg cccggggcct gcgggtcctg ctcctggcgc gcagcgaccg 7980 gccgctggac acgctgatgg acgaccccgc ggccgtgccc gccgccgtca cggccgccgc 8040 gctcgtcgtc atcaagcagc gggtgcggcc ggaggcgcgg gccaccctgg actacttcgc 8100 cgaccagggc gtcacggcca aggtgatctc gggcgacaac gcggtctcgg tgggagccgt 8160 ggcgtcgagc ctgtcgctgc ccggggcgga acggccggtg gacgcccggt tcctgccgga 8220 cgagccggcc gaactggccg acgcggtcga ggagaacacc gtcttcggac gggtggggcc 8280 gcagcagaag cgggacatgg tgggcgcgct ccagtcccgc gggcacaccg tggcgatgac 8340 gggcgacggc gtcaacgacg tcctcgcgct caaggacgcg gacatcggcg tggggatggg 8400 ctcgggcagc ccggccaccc gggcggtcgc gcagatcgtc ctgctgaaca acaacttctc 8460 ggcgctgccc tcggtggtcg cggaggggcg ccgggtcatc ggcaacatcg agcgggtggc 8520 caacctcttc ctcaccaaga ccgtctactc ggtgctgatg gcgctggtgg tcgtgatcgc 8580 ccaggtgccc tacccgttcc tgccgcgcca catcacgctg gtcgggtcgc tgaccatcgg 8640 catccccgcg ttcttcctcg ccctcgcgcc caacaaggag cgggcccggt ccaacttcgt 8700 cggccgggtg ctcaggttcg cgatcccggc cggcgcgctc gcggccgccg ccacctcggt 8760 cgcctatctg atcgcccggt cggtgtacga cgacaacctg gacgccgaga cctcggcggc 8820 gaccctcgcg ctgttcctca cggccctgtg ggcgctggcc gtcatcgccc gcccctacac 8880 ctggtggcgc gtgctgctgg tgctgaccat ggcggtgggc ttcgccgtgg tgctggtggt 8940 gccctacctc caggagttct tccagctgaa gctggtcggc gtcaccgcgc cgtgggcggc 9000 ggtcgcctgt gcggcggtcg ccgggctggt gctggagttg gtgtgggcac gtatgcggcg 9060 tcgtctcgac gccgactgag cccaccgggc ggtcgacccc cgtaccgccc ggtgaagagg 9120 aggggacgcc cggtccgtgc cgggcgtccc ctccgtcttt gtgcgccccc cgccgaccgg 9180 aacggcacga tccggccaaa cctgcgcagc ggtgcggccg gaggagccgc ttccgggccg 9240 ttcgacgggc ggcccgccac gggaccggaa cgagccccgg catccgccgc caccagcgga 9300 tttcacattc cttacgcaat cggcggcgag agcgaccggc aggtaacctc ggggctgaat 9360 ccaggccatc ggggaatagc aaacggcgca ctgacgaaag caagggcaga gacctgccga 9420 aagttgagtg ttggattcaa agaagatccg tattattccg actgcaggca ggggggagcc 9480 ggctacgaag gaaaagttcc gcaggtcaga ttgggccggg tcgcaggcag cgccgcaccg 9540 gcaaccacga ccgcgacttt cgtcgacgca ccccctcgca ccgccgcccg gccaccggtc 9600 cgggcgcacg acccgaaggg aagtgaggct cacgcacgga ccagcagctc ctgacgcagc 9660 gacccggacc cggaggtgag tgacatgacg acgaggcccc gaccagcggt gaaccctgct 9720 gacccggccg taacgaagtc ttcatgcccg tggcacccga cggcttcgga gagtttcggc 9780 acgcagacat cagcacaact tgacgcgggg gtatcaagag gtcatggatc ttcggctgat 9840 agaaccgata taccagagaa tcggaaatgc ggaagtctcc caaaaggaaa ccccgaccgc 9900 cggtctcgaa ttcggagtgc tcgggccact cgaagtgcac atgaatggcc gaggtcttac 9960 ggtgggcggc ccccggcaac gggccgtgct ctccgcacta cttctctccg ctaatcaggt 10020 cgtttctttc gactccctga tcgaggaggt ctggaacggc cgtccgccca gtaccgcgcg 10080 cacccaggtg gccatttgca tcgccacact gcgcaaaatc ttccgtaccg cgggctggga 10140 acaggaaacc atcatcacgg ccacacccgg ctacatgctc agcctcgccg gccactcact 10200 cgactcgctc cgtttcgaac aactggtctc cagagccacc gaactgacgg cggacgaacg 10260 tccggccccg gcggccgagg cgctgcgcca ggccctggcc ctgtggcgcg gccccgccct 10320 gggcggcgtc cacgcaccct tcgccgagac cgaggcggcc cggctggacg aacagcgcat 10380 gctggccgtc gaacagcaca tggcgctgcg cctccaactc ggcgagcacc agtcggtcct 10440 gggcgaactc caggcactgg tcggtgcctg cccgctgcgc gaccggctgc gctactacct 10500 gatgctcgct cagtaccgtt cgggacggcg ggcggaggca ctcacgacat tccgcgacgg 10560 aatgcggtat tccatcgaag agatcggtct tgaactgggt accgacctcc agtcgctgca 10620 cgactcgatc ctgcgcgacg aattcccgca gctcggcgtc ctgggcatag cggcggcgcg 10680 aaaggaccgg cagcagaccg ttccgagtca gcttccggaa agcgacgcct acttcatcgg 10740 gcgtagccgc gagcagtggt tgatggatga tgtgctgctc gacggatcgg cgcagaatcc 10800 gcccgccatc gcctacctca ccggaagtcc cggaatcgga aagacgagcc tggcggtcaa 10860 ctgggcgcac cgtgcggcgc acagatttcc cgacgggcag ctcttcgccg acctgcggga 10920 gggcggcccg ctggaggtgc tccaccagtt cctgcgccag ctgggggacg agggtccgct 10980 gcccgccgag cccgcggagg cggcggagcg gtaccgcgga ctgctggagg gccggcgggt 11040 cctgatcgtg ctcgaccacg cctcctccta cgcccaggta cgtcatctgc tgcccacgag 11100 cggcgggtgc tgcgtactca tcaccggccg ggccaatctg gacgagctga tgcagaagta 11160 ccgcaccttc cggctgcggg tcgcgcccct gtcggacgac gaggcgcggg agacgctggc 11220 cggcgtgctg cgggactcac gggcgcagga cgtgcccgag gcgaccagca ggctcgccgc 11280 gctgtgcggg cattcgccgc tggcgctgcg ggccgccgcg gccaggctgc tcaccaagac 11340 gcactggcgg gtgctcgacc tggtatgccg gctggaacgc tcgggcgacc ggctgacggc 11400 cctcagcatc ggggaggact cgctgcgcgc ccggctggac cgcagcatgc gggagctgga 11460 ccccagggtg gccttcgcct accgggagct gagccgcctc ggcgacgcgg acttcgacgc 11520 ggagcaggcg gcccaggtgc tcggcacgga cctgctggag gccgaggacc tgatcgagac 11580 cctggtcgac gcgcagctcc tggaggcggt cggccgcagc cgctggggcg ggatgcgctt 11640 taagtggcag gagctggtac ggctgcacgc gtcccactgc ctgacggccg cggggtccct 11700 ggagaccccg gccccggtcg ccgtggccct caccgactga gccgggaacg gcgacggccc 11760 gtacgccccc tgccggggac gtacgggccg tcgtggtccg gtcagttgcc ggtgctcatc 11820 gcctccacga ggctcctggg ccgcatgtcg gtccagttct tctccacgta ctccaggcac 11880 gcctcccggt cggactcgcc gagggcgacc gtccacccgg cgggcacgtc cacgaaggac 11940 ggccacagcg agtgctgccc ctcatcgttg accagcacga gatagcggcc gtctgcgtct 12000 tcgaacggat tggtcacgtc gcattccttc cgggagcgtc gggctggaga ctctgcgcgg 12060 gtcgcggacc ctgccgaccc cggtcaaggt actgagaccg tctttccttc cgatatcgat 12120 ccgttttccc acgggccgct cagcgtccgt gggtgacgac ctccgggtcc tgccgggcgg 12180 cggtgtcgag gcgtggcccg taccgccgca gccgttcgtc gaggaaggcc accaccagct 12240 ccctggtgac gcgcccggcg tcggccgcgc cgagcgtgac ctcctcgccc gccgtgccgg 12300 tgcgttcgag gagccgggcg tagtcggtga aggacaggtg cccggcgccc cgcaccgaca 12360 gccagcggcg cggccccgac aggtcccgcc aggcccgctg ccaggtgggg tcggcgccgg 12420 gccggccgtg ttcgccggcg ccgagcagca ggaacggccg gtccaccggg ctcctgccgc 12480 cggtgtggac ggtgccgtcc aggttggccg cggcggcgaa gccggcgtcg gtgcgcagcg 12540 cctcgaaggc ggcggcgccg cccatcgagt ggcccaccac cgccacccgc gacgggtcga 12600 gccgcggcag ccccacggcg cccggcgacc gcagcagccg ctcgcgcacg aagcggaggt 12660 ccgcggcgcg ggtggcggcg acccgtgcgc cctccgggtg ccgtcggcag gccaggcagc 12720 cggtcacgcg gccgtcgggg tggctgatgg ccggggcctc gtaggcgtgg tcgaccgcgg 12780 cgacggcgta cccgcggctc gccagctcct cggcgagccc ggtcagcgac gagcggggca 12840 gcgcgaagcc cggcgagagc aggacgaggg gcagcccgcg ggcgggcgcg ggcagcggcg 12900 gcggggccgt gcgcgcgtgg acgcggaaac gggcgagcag gtcggcgggc acgccctcga 12960 cccggtggaa gcgcaggatc agcgccgact cccgggccgt gacgtacgag gcgcgcggcg 13020 cccgcgaggg cagcgccggg taccagagcg agagggccag ctcgcggtac cggtcggggt 13080 tccaggggtc gcgccgggag gtgtcgcgca ggtgcgcggt gcgcacgccg accggcaggg 13140 cgccggtcgg cgcgggcacg gcggacgcgg tccacgcggc gtcggcggcc ggcgcggccc 13200 gcgcggctgc cgtgccgggg gcgcccgcgc cgaagggcac gagggccagc agcagggccg 13260 ccacgagggt ggcacaccgg cgcgccggac gaccggcttc cctcacgttc ggcatcagcg 13320 ctcacttcgt cggaagcagg aacaccgatc acgctaggag cgggaagcac gaggtgaaag 13380 cggcaacggc ggtttcatca ccttggtcgc cacaagtgga tgcgatcttc gtgggccggc 13440 cggtgaagcg cctggacttc cgtcgtccgc ccgcacgccc ggccctgtcc tttcgacagg 13500 gccgggcgtg cgggcgggag cgtcacatga agaccatcgt gagatgggtg tccgccacgc 13560 ccgtgacatc cttggggccg tactccgact cggtcgggtc gtagtcgaac tcgacgtagg 13620 gcttgtcggt gaagtgcggg caggccaggg tgctggtgct ggagtcgggt ccggacgccg 13680 tctcccagtc gatccaccag cccacgcagc cggagtcgcc tccgttgaag gggccgccgg 13740 gcttgaggtc ctcgacgtgg ccggtcaccc gtacctcgcc gtcctcgacg cagacggtga 13800 tctcgccccg gccgaagtcc tcggtctcgc tgtccgtgac acagccggag gccgcgggcc 13860 cggcgggcgc ggcggaggcg gccgtcgtcg ggagcagggc gaccgcgccg atcgccgcgg 13920 tgagcgccgt ggcgcgcagg attccacgca tggtcgtgtc ctttccatcg gtggtgccgg 13980 atgacggtgg tggcgcgggt cctcgggatg ccggggccgc ggcggtccgt cgcccccggg 14040 gggtcaggac gagggagtgt gcggctcccg gatgcgggcg cgtccggcca cgccgaagcg 14100 cagggtctcc cgcagccgga ccgggccgtc ggtgtcgccg gaccgcgcgg cgtccctcag 14160 ttcgcgggcc atcgcctgcg cctcggccgc ccagtcgtcc aactggtcgg cgacgggacc 14220 ggcgttggcg gtcaggatgc gggcccagcg ttccgggttg gcgtccgcgg tcctggtgac 14280 gtcccgcagg tcctggccgg ccagccgtac ggccgactcg tcgccgccga gcagccgcgc 14340 ggcgaccagg ctcgcgacca ggtgcggggc gtgcgagacg agggccacgg cgcggtcgtg 14400 ggtctcgggg tccagcagca ccgagaccgc cccgcacagc gcgaccagtt ccagcgcgca 14460 gttcagggcg aggttcccgg tggcctcggt gggcgtgagc gcccagggcc tgccgtcgaa 14520 gaggtcggcg cgggcctgga cggggccgct gccgccgacc acgggggcgc cgctgaccag 14580 ggaggtcagg tcgcagccgt gcgccctgac ctcccggtgc agacgcacct tgacgccgga 14640 gacgtcggtg tagcagcggg ccgtgccgag cttctggtgc tcggcgagca ccggcgcgac 14700 ctggtcgggc ggcaccgcga gcaccgcgat gtcggcctgt cgcggcggcg gcgccgcgaa 14760 gccggccccg cagcgttcgc ccgccagcgc cgcctcgggg tcggcgtcgg tcaggtacgt 14820 ggtcacgccg tgccgccgca gggcgagccc gacggagcgg ccgatcacac cggcgcccac 14880 gatgacgacg ctgcgcatgc gtcttcccct cctcggcccg gggcccgcgc tgcctgctcc 14940 gccctgctcg gctcggcagg ctcgttcggc tcggctcggc tcagctcggc tcggctcagc 15000 cgaagatctt gacggcctgg tagtaggtcc aggcggtgct gttgcaggcc gtgttcttct 15060 cgccggtgta gccggtgcag acgcgcttca tgtcctcgta gaaggcgctg tcgatacggc 15120 tcttgttggc gtcgaagctg cccgccgcct tgtagttgcg gtaaccgaag tcgtggcgcg 15180 cgcaggccgt gttgaacggg aagccgaagg ggttgtcggg cgcctgggtg cacaggtccg 15240 tggaccagtc gaactcgtag gcggcccagg cggactggtt ccggttggcc gcgagccagg 15300 cgttctggct ggacgcgctg gtctgcgtga aggaggcgag tacctggggc ttgtccgcgg 15360 gggccgcctg ggcgggcgcg gcggcgacgc cgagggcgag cgccgcaccg acggcggcga 15420 gcgtggtccg ggtcctggtg gtggtgcgca cgggcggcct ccaaggtggg gggcggatac 15480 ggctccacca ccttggctgg gcccgctatg ggccccttat cgcaccggta tcgacgaagg 15540 ggccgtgctc cggcagccgg agcacggccc ccggctcccc ctggggagcc cggacgagtg 15600 gcgggtcagg cgtcgcggcg gcgcagcacc gcggtgccgg cggcgtaggc ggccagggcc 15660 cacagcagga ggaccagcag tgcggtgccg gcgccgtagg ggtcgctgtc ctgggtcagc 15720 aggacggtac cggcgacgct cggcatgtag tccgaggcgg tctccagcca cttggcgccg 15780 acgacgccca tcagctgggg cagcgcgagc aggaccatga tgagggtggt gatggtgccc 15840 gcggcgctgc gcaggacggt gccgagcccg atggccatga cggcgaggag ggcgaggtag 15900 accccggcgc cgagcgcggt gccgaacagc tggccgctgc tgtagtcgcc gtagtcgccc 15960 atcaggggcg cggccaccag ggtgcccagc aggctgaaga cgaagcccga cgcgaccacg 16020 acggcggcga cgaccagggt cttggagcgc agcatccggc cgcgcgcggg cacgctctgc 16080 aacgtggtgc ggatcgagcc gctggagtac tcgctggtga gggcgagggt ggcgaggacc 16140 acgatggtca gctgggagat gaggaaggcc tgcgaggcgt ggtgcggggc gggcatcgtg 16200 acgtcgacgc ccttcttcgc gctggcgtcg gcggaggcgc cgaccatggc ggcgaaggcc 16260 acggtgagca gcaggccgac ggccaggttc caccaggtgg cccgcacgct ccagaacttg 16320 gtccactcga aggcgacggc gcccttgaag ccgccgccct tcacgggacc cacgagcttg 16380 gggacggttg tagtagtcat atccagttac gccttctggt ggtccgggac ttcggtgacc 16440 tgggagagcg cgggagagcc gtactccacg ctcgcggcgg tgagttccat gtacgcctgt 16500 tccaggctgg ccttgcgcat gctgagttcg tggatcggaa cgcggtggtg gaaggcgagg 16560 tcgccgatct cctccagggt tccgccgacg acgaggagtt cgtcgggcgc ggagtccgcg 16620 ttcggctcga cgcgcagtcc gaactccagc agctcccgcc tgagcacgtc gggctgcggg 16680 gtccgcaccc gtacggcggt cagcgagctg cccgcgatga cctcctcgat cggcgcatcg 16740 gcgatgatct ttccgcgccc gatgaccagg aggtggtcgg cggtctcctg catctcgctc 16800 atcaggtgac tggacacgaa gatcgtcctg ccctccgccg cgagggaacg catcagctcg 16860 cggacccagc ggacaccgtc cgggtccagt ccgttgaccg gttcgtcgaa gagcagcacc 16920 ttggggtcgc ccagcagggc ggcggcgatc ccgagccgct ggcccatgcc gagggagaag 16980 gagccgatgc gcttgttcgc cacctcggac aggcccacgg tctgaaggac ctcgccgacc 17040 cgggacgccg ggatcccgtt gctgcgggcc agcccgagca ggtggtgccg ggccgaacgg 17100 ccggggtggc ccgcgcgggc gtcgagcagc gcaccgacct cgcgcaacgg gtgccgcagc 17160 tcctcgtaac gcttgccgcc caccagggcc cgccccgagg tgggcgcgtc cagaccgacg 17220 atcatgcgca tcgtcgtcga ctttcccgcg ccgttcgggc cgaggaatcc ggtgaccttt 17280 cccggattga tctcgaacga gaggtccgag acggccgtct tgtcgccgta ccgcttggtc 17340 agtcggtcca aagtgatcat cgcctggtgg ctccttccaa agtcacgtcc tcaacgctag 17400 ggagaggcag gggcacgaaa catctggcga tcggcaacga ccgcagtcga ctttcggcag 17460 atccggcggc cggggccgct cttgtagcgt gctggaatgc accgatggca ggccgtgcgc 17520 cgacgaatcg aatcgcttgt acgggtcctc ggctccgagc gcccgttcac ccggcgcgcc 17580 gatctggtgc tgctgctcgt actgctcgtg ccctccgcgt tcgccaccgg gacgctcgag 17640 accgcgccgg tcgcctggct gaccgcgtgt ctgctcatcg cggccgcggt cgtggtgcag 17700 cgcaccgcgc cgctgctgtc cctgctgctc gcggcgctgc tcacgctgtt ctatccgtgg 17760 ttcggggcga acctgtggcc gtcgatggcg acggtggtgc tgagctgcct cgcgggccgc 17820 agactgaccc ggctgtggcc cgcgcacctg gtgttcctct gtgtcgccgc ggccgggctc 17880 ctgctggtgg ccaccgtcgg ccagggcaag gactggctga gcctgctgat gaccgagttc 17940 gtcgcctgtg tgctgccctg gtgggcgggc aactggtgga gccagcgcac cgcgctgacc 18000 cacgccggct gggagcacgc cgagcaactg gagtggcgcc agcgctacat cgccgaccag 18060 gccaggatga aggagcgggc caggatcgcg caggacatcc acgactccct gggccacgaa 18120 ctgagcgtga tggccctgct cgccggcggc ctggagctgg cccccgggct gtcggacccg 18180 caccgggagt cggtgggcca gttgcgggag cggtgcacga tggccaccga gcggctgcac 18240 gaggtgatcg ggctgctgcg ggaggacccc aatccgtcgc tgacccccgc cgacgagtcc 18300 gtcgcccagc tcgtgcgccg tttccagcgc tccggtacgc cggtccggtt ccaggaggac 18360 ggggcccggg accgccccgg cacgccgctg ctgtccgacc tcgcggccta ccgggtggtg 18420 caggaggcgc tgacgaacgc ggccaagcac gcgccgggcg cgcccatcga cgtacgggtg 18480 acgcacaccg cggacgagac ggtggtgtcg gtcgtcaacg agcggccgga gcggggcggg 18540 agtgttccgg cggccgggag cgggtcgggg ctgatcggcc tcgacgagcg ggtccggctc 18600 gcgggcggca cgctgcgcac gggcccgcgg gcgggcggtt tcgaggtgta cgcgcgactg 18660 ccgcgcggcg cctcctcgcc gtcgcggtcc accgagccgc cggggccggc cgacggggac 18720 ggcacggccg gtggctcggg cgacggcacg gcgcccgggg ccgcgacggc cggcaacgag 18780 gggcgggccg cggccgccgc ggcggacctg cccgccccct ccgggccgtg gcgcagcgcc 18840 tcccgggccg cgctgctgcg cacccgggcc cggatcaggc gggacgcccg gcgggccgcg 18900 ctgatacccg cggtgctcgg cgccgccatc gtggccttcc tcggcgggct ctacgtcttc 18960 acctcggcga ccacgtccct cgcccccgag gactacgccc ggatccgggt gggcgagacc 19020 cgcgccgatc tggcgcccgc gctgccggag cgccggatca agaagccgcc gccggtcacc 19080 tccgagccgt ccgtcccggc cggcacgacc tgcgagtact accgggcgag cagcggtctg 19140 ctcgacttcg gcggcgccat gtaccggctg tgcttcaagg atgatgtcct catggccaag 19200 gacacgctct gaccaccagg gaaggatcgg atgattcgcg tactgctcgc cgacgacgag 19260 accatcatca gggccggggt tcgctccatc ctgacgaccg aaccgggcat cgaggtggtc 19320 gccgaggcgt ccgacgggcg ggaggcggtg gaactggccc gcaagcaccg gcccgacgtg 19380 gccctgctcg acatccggat gccggagatg gacggcctga cggccgcggg tgagatgcgg 19440 accaccaacc cggacaccgc ggtcgtcgtc ctcaccacct tcggggagga ccggtacatc 19500 gaacgggccc tggaccaggg cgtggccggg ttcctgctca aggcgtccga tccgcgggac 19560 ctgatctccg gcgtacgggc cgtggcgtcc ggcggctcct gcctctcccc gctggtggcg 19620 cggcggctga tgaccgagct gcgccgggcc ccctcaccgc gctcggaggt gtcgggggag 19680 cgcacgacgc tgctgaccaa gcgggagcag gaggtcctcg gcatgctggg ggccgggctg 19740 tcgaacgcgg agatcgcgca gcggctgcac ctggtcgagg gcacgatcaa gacgtatgtc 19800 agcgccatct tcacccagtt ggaggtccgc aaccgggtgc aggcggcgat catcgcgtac 19860 gaggcgggac tggtgaagga cgccgacctc aaccgttaga cgccgcgcgg tccttgacga 19920 agcgggccag ccgcgtcgcc ccctcggcgg cgcggtcggt ggtgaggtag ctgcacgaga 19980 ggcggatctg ccggtcgccc gcgtcgtcca ggtggaagtg gcgcatcggg gtccagatga 20040 cgccgtactt ctccgcggag acgtccagcg cggcctcgtc cgcctcgaag ggcacgtcga 20100 gggtcaggaa gaacccgccg tccgggtcgt tccaccgcac gccgcccgat tccggtgcgc 20160 cgggcggcag ttcggcggcg agggtgtcgc gcaggcaccg catcgtggac tggtagtggc 20220 gggccgaggc ctcgttcgcc gcccgcagtc ccccgccgtt ctgcagcagc agtccggcga 20280 ccgcggcctg gctcagggtg ggggtgttga cggtgaccat gctcttgacc ttggccagtt 20340 cgtgggcgag cagaccgggc ggccgcccgt ccgcgccggc cacgagctgg tcggcgacga 20400 cgaagccgac gcgggcgccc gggaaggccg tcttcgcgaa ggaaccgagg tagacgacgc 20460 gccgttcggt gtcgagggac ttgagggtgg ggcggcgcac ccggctgaac accccgtagg 20520 gattgtcctc caggaggagc aggtccagcc gcgcggcggc gtcgagcagg gcggtgcggg 20580 cctcgcggcg caagctgacg ccggtcgggt tggagcagtc gggcaccacg tacaggcacc 20640 tggcgcgccg gccgctcgcc tcgatctccc ggacggtgcg ctccagccct tccgggctcg 20700 gcccgtcggg ggtgccgggc accggcacga cggggatgtc cagcaggccg gccgcgccgg 20760 tgatgccgac gtaggcggga ctgtcgacga ggagcacgtc ctccggaccg gtgaacaggg 20820 cgcgcagggt gagcaggacg gcctcctggc agccgaccgt caccaccacg gaggcggggt 20880 cgaccgtcag gtcctcgtcc acctcgagca tgcgggcgac gatgtccctg atctgcccgg 20940 cggtctcgcc gtactggtag agcgcggtgc ggacgcgctc ctcggagtgg ccgcgcccgc 21000 gcaggtggtc gaggtaggtc tcgatgtacc cggggacgcg tgcgacgtcg aagtctccct 21060 cgtaggggcg tcccggggcg aaggagatcg cctgcgggta gcggagggtc acctcgttga 21120 ggaagttcat cgtgtcgagc agcggggcgg acaggctggg gtgcagggcg gtccgcgcca 21180 ggacgccgtc ccggtccgtg cgcgctgggg tggtggtggt catccgtggc tcctgtctcg 21240 gtgcggcgcc gggcggggcg cggtgggcgg cccgtggtgc ggcggggcgt ggtgcggcgg 21300 ggccagggtg tccgggccga tcgtgccggt ggcggcgtgg ccggtgagca ccatcgtgtc 21360 cgcgaagtcc tcggtcagca gggtgagcat ccggcgcacg cccgaggcgc cgccgaccgc 21420 cagcgcgtac agcgcggggc gcccgaccag gacggcacgg gcaccgaggg ccagggcggc 21480 gaggacgtcg gcgccggtgc ggacgccgcc gtcgaggagg accgggcagc gtccgcgcac 21540 ggcggacacc acctcgggca gcgcctccag ggtggccggt gcgccgtcga gttggcggcc 21600 cccgtggttg gagacgacga tgcccgcgac gcccgccgcg accgcggcct cggcgtccgg 21660 cgcggtcagc acgcccttgg ccagcaccgg caggccgctc gccgcgccca ggcgggccac 21720 gaaggaccag tccaggcggc ggtcgaaggc cagcctgctg tgcgcgccgg gggtggcgct 21780 gccggccgcc gccgtgccgg tcaggttggc cggggtgatg tgggcgggga ccgcgaagcc 21840 gttgcgcagg tcgcgcagcc ggcggccggt gaacggggtg tcgacggtga gcaccagcgc 21900 ctggtagccg ctgtcgcggg ccctgcgggc caggcccagg gtggtctcgt ggtcgcggaa 21960 gcagtacagc tggagccaca gcggtgcgct cgccgcgcgg gccacctctt cgaggctccg 22020 gccggcgaag gtgctgacga cgagcgggag tccgagcgcg cccgccgccg cggcggtcgc 22080 cggttcgccg tcggggtggg cgagcccgtg gtaggccacc ggcgcgatgc ccacgggcgc 22140 cggccaccgg gagccgagca cctccacgga ggtgtccggc tcctcgatgc cgggcagtgc 22200 cctgggccgc agccgtacgg ctccgaagac ggcctcgttg gcggcgaggg tccgctcccg 22260 ccccgcgccg cccgcaatga agtcccaggt ggcggcaggc agttgcccgc gtgcgagtcg 22320 tgcgaagtcg tcgagcgtga gcggctcccg caccccggcg ccggcgccgc ccgccgcgct 22380 cccggccgcc actggcgccg gggccccgga cccgccgggt gccgccggtg ccgtgccccc 22440 ggacccgccg cggtccgccg gtgccgggtc ttcggggtcc gccgggtgcc ggacggcgga 22500 ggtcatcggc cggccacttc ccgctcccgc tcgacggcct cgtacagggc cttgatgttg 22560 gaactgccga agccgcgggc gccgttgcgc tggatgtact cgtagaagag ggtgccgcgc 22620 gggtagggcg agcgggtgaa gatctgcagc aggtagcccc actcgtcgcg gtccgcgagg 22680 acgttggtct cgcgcaggtc ctcgatggcg tcggccatcg cgccgacccg ctcggtgagc 22740 aggtcgtagt aggcgcccgg ggtgcgcagg aaggccacgc cgcggtcgcc gagcgagcgg 22800 accgagccga cgatgtcgtc caccaggaag gccaggtgct ggacgcccgg cccgtcgtgg 22860 gcgctcagga actggtcgat ctggcccggc acccgggtgt cgtccggttc gatgagcgtg 22920 aaggtgatgc cgccgccggc gttgcgcacg acgatggagt ccatcgcctg ctcgcccacc 22980 tcgatgtact cggaggagta gtagggcatg tcgaaggccg cttcgtagaa ctcggcggtg 23040 ctccgcagcg tgccggactc caggcagacg gcgacgtggt cgaggagggg ccgcggcccc 23100 gtgcggccgg tggcggccgg gagcagcgcc cagtcccggt cgggcggcag cagccccgcg 23160 ccgtccccgt ccgccgccgg gaccagggtg tgccggatgt ccccgaagcc ggagacggtg 23220 gcgaaccacg cgtcctggcc cgcccggtgg gagggcgtcg gggcctgaag cgcctcggca 23280 ccggcgagga ccgcgcggtc gaagcaggag cgcacgtcgt cgcagccgaa ggcgaggtcg 23340 gcgatggagt cgccgtgccg ctccacgtac cgggcgaccg gggtgtccgg cgccagcgcc 23400 tgggtgacca cgagcgtgac ctcgccgctg cgcagcaccg tggaccggcg gtcgtgggtg 23460 ccggtggcgg ggcccgccac cgccaggggg acgaaaccga ggctgtcgac gaggaagccg 23520 gaggcctccc ggtcgtccgc gacgtacagc tcggcgtacg cgatgtcact gggcggcatg 23580 gcggctctcc aatgaaggaa ggggaaagga gggagcactg agggagcgcc cgccggggag 23640 agggaagggg gccctctctt tctccggcag caatgagaaa tgcacgttgc cacactctac 23700 aaatgacccg tataacctcg ctatcgactg gttatcaagg ctcctacctg cggttatctt 23760 ccctaataag catattgacc agctcgtcgc ggccttgcta gcgtcccagt tcgccctcaa 23820 tttaatgccg tccggtaaat gccgcacggg cacacatctt gttcgttttg cattgtgagg 23880 agacaggtgt ctgagaactc ttcggttcgg cacggtctga cgagcgcgca gcacgaggtg 23940 tggctcgccc agcagctgga tccgcgtggc gcgcactacc ggacgggatc ctgcctggag 24000 atcgacggac ccctggacca cgcggtgctg agccgcgccc tgcggctcac cgtggccggt 24060 acggagacgc tctgctcgcg cttcctcacc gacgaggagg gccggccgta ccgcgcgtac 24120 tgcccgcccg cgccggaggg ttcggccgcc gtcgaggacc cggacggggt gccgtacacc 24180 cccgtgctgc tgcgccacat cgacctctcc ggtcacgagg accccgaggg cgaggcccag 24240 cggtggatgg accgggaccg cgcgacgccg ctgccgctgg accggcccgg cctgagcagc 24300 cacgcgctgt tcacgctcgg cgggggccgg cacctgtact acctgggcgt ccaccacatc 24360 gtgatcgacg gcaccagcat ggccctgttc tacgagcggc tggccgaggt gtaccgcgcg 24420 ctgcgggacg ggcgtgcggt gcccgcggcc gccttcgggg acacggaccg gatggtcgcg 24480 ggcgaggagg cctaccgcgc gtcggcgcgg tacgagcgtg accgggccta ctggaccggc 24540 ctgttcaccg accgccccga gcccgtctcg ctcaccgggc gcggcggcgg ccgggccctc 24600 gcgccgaccg tgaggagcct gggcctgccc ccggagcgca cggaggtgct cggccgggcc 24660 gccgaggcga ccggtgcgca ctgggcgcgc gtggtcatcg ccggtgtggc cgccttcctg 24720 caccggacga cgggcgcccg ggacgtcgtg gtgtcggtgc cggtcaccgg gcgctacggc 24780 gcgaacgccc ggatcacccc cggcatggtc tccaaccggc tgccgctgcg gctggcggtg 24840 cgccccggcg agagtttcgc gcgggtggtc gagaccgtgt ccgaggcgat gagcggcctc 24900 ctggcgcaca gccgcttccg cggcgaggac ctcgaccggg agctgggcgg cgcgggggtg 24960 tcggggccca ccgtcaacgt catgccgtac atcaggccgg tggacttcgg cggtccggtc 25020 ggcctgatgc gcagcatcag ttcgggtccg accaccgatc tgaacatcgt gctgaccggc 25080 acccccgagt ccggcctgcg cgtcgacttc gagggcaacc cgcaggtgta cggcggccag 25140 gacctgacgg tgctgcagga acgcttcgtc cggttcctgg cggagctggc ggccgacccc 25200 gcagccaccg tcgacgaggt cgcgctgctg acgccggacg agcgggagcg ggtcctcgac 25260 gggtggaacg acaccgccca cgaggtcccg gagaccacgc tgcccgagct gttcgccgcg 25320 cgggccgcgc gcacgcccgg gcacgaggcc ctggtctacg agggcacctc gctgacgtac 25380 gccgaactgg acgcccgcgc cgagcggctg gccggtgcgc tgacggcgcg gggcgcgggc 25440 ccggagcggt tcgtcgcggt cgccgtggag cggtccgcgg agctggtggt ggcgctgctc 25500 gcggtgctca agtcgggcgc ggcgtacgta cccgtggacc ccggctaccc ggccgaccgc 25560 atcgcgcaca tcctgcggga cgcgggcgcg atgctggtgc tgaccacccg ggacacggcg 25620 gagcggctgc ccggggacgg cacgccgcgg ctgctgctcg acgagccggc cgcggcgggg 25680 accaccgcgg cgggggcacc cgccccgccc ggcaccctcc cgcgggcgct gcccgctccc 25740 ggccaccccg cctacgtcat ctacacctcg gggtccaccg gccgccccaa gggcgtggtg 25800 atctcccacc gggcgatcgt caaccggctg gcctggatgc aggacaccta cggcctggag 25860 ccgtccgacc gggtgctgca gaagacgccg tccggtttcg acgtgtccgt gtgggagttc 25920 ttctggccgc tcgtccaggg cgccaccctg gtcgtggccc ggcccggggg ccacactgac 25980 ccggcctacc tggccggcac cgtccggcgc gagggcgtga ccaccctgca cttcgtgccg 26040 tcgatgctcg acgtgttcct gcgggagccc gccgcggccg cgctgggcgg tgcgacgccg 26100 gtgcggcggg tgttctgcag cggcgaggcg ctcccggcgg agctgcgggc ccgtttccgg 26160 gccgtgtcgg acgtgcccct gcacaacctg tacgggccca ccgaggccgc cgtcgacgtg 26220 acgtactggc cgtgcgccga ggacaccggc gacgggccgg tgccgatcgg acggccggtg 26280 tggaacaccc ggatgtacgt gctcgacgcc gcgctgcggc cggtcccggc cggggtgccc 26340 ggcgagctgt acatcgccgg tgtgcagctc gcccgcggct acctgggccg ccccgcgctg 26400 agcgccgaac gcttcaccgc cgacccgcac ggcgcgcccg gcagccggat gtaccgcacc 26460 ggcgacctgg cgcgctggaa ccacgacggc agcctcgact acctcgggcg cgccgaccac 26520 caggtcaagc tgcgcggctt ccgcatcgaa ctcggcgaga tcgaggccgc gctcgtacgg 26580 cagccggaga tcgcccaggc cgccgtcgtc ctgcgcgagg accgccccgg cgaccagcgc 26640 ctggtcgcct acaccgtgcc ggctcgggac gcggacacgc tcacgggccc gcctgcggag 26700 gcggggacgc accccgggcc gggcgccgca ccggacacag acccggccac cgggcccgcc 26760 gccgggacgg actccggccc ggggtccgga acggggtccg gaacggggtc cggaacgggg 26820 tccggagcgc gccccggacc ggacggcacg gcgacgcaca ccgttgccgg cgccggaccg 26880 gccgcggccg gggaaaccgc cgccggggcg gacgccggga ccgggaccgg ggaaaccggc 26940 gccggggcgg acgccgggac cgggaccggg gcacacgccg gcccggacgg tgccgtgctc 27000 gccgcgcggc tgcgggagtt gctgcccggg tacatggtgc cctcggcctt cgtcgcgctg 27060 ccccggctgc ccgtcacacc gaacggcaag ctggaccggc gggccctgcc cgcccccgcg 27120 gagtccgggc gcgccgccgg gcgggcgccg cgcacgccgg gcgaggagct gctgtgcgcg 27180 ctcttcgccg aggtgctcgg cgtggccgag gtcagggtcg acgacggctt cttcgacctg 27240 ggcggccact cgctgctcgc cacccggctg atcagccgca tccgcgccac cgccggggcg 27300 gaggtgccga tccggcgcgt cttcgaggcg ccgaccgtgg cggagctggc cccggcgctg 27360 acggacggcg ggcgggcccg tgccgcggtc accgcccggc cgcgccccga ccgcctgccg 27420 ctctccttcg cgcagcggcg cctgtggttc atccaccagt acgaggggcc ctcgccgctc 27480 tacaacatcc cggccgcgct gcggctgacg ggcccggtgg acggcgccgc cctgtcggcg 27540 gccctcggcg acgtggtggc ccggcacgag agcctgcgca ccgtcttcgc cgaggacgcg 27600 cacggccccc accaggtgat cctgtccgcc gagcgggccg cgccccggct caagacgctg 27660 gacagcgacc cggagcggct ggccgccgac ctcgcgcgca ccgcccggca caccttcgac 27720 ctgacccggg acgtaccgct gcgggccacc ctgctgcggg tggcgcccga ggagcacgtg 27780 ctgctcctcg tcctgcacca catcgcgggc gacggctggt cgctggcgcc cctcgcccgg 27840 gacctgggca ccgcctacgc cgcccggacc gccggcacgg cccccgactg ggcgccgctg 27900 ccggtgcagt acgccgacta cacgctgtgg cagcgtgaac tgctcggcgc cgacgggaac 27960 ggcgcgggca ccggggacgg cggtgagggc gcccggcagc tcgcccactg gcgcgaggcg 28020 ctggccgggc tgccggagcg gctggagctg ccgagcgacc ggccgcgacc ggcgcgccgc 28080 gacaactccg gcgcgcgcct ggacgtgtcc gtgcccgccg ggctgcaccg ctcgctggcc 28140 gcgctcgccg ccgagacgcg gaccagcgtc ttcatggtgc tccaggccgc gctggcgggg 28200 ctgctgaccc ggctcggcgc gggcgaggac gtgcccatcg gctcgaccat cgcgggccgc 28260 accgacgccg ccgtcgagaa cctggtcggc ttcttcgtca acacgctggt gctgcgcacc 28320 gacaccggcg gcgacccggc cttccgcgag ctgctctccc gcgtccgcga gcgcgacctg 28380 gccgcctacg cccaccagga cgtgcccttc gagcggctcg tcgaggcggt caacccggac 28440 cgggccacct cccaccaccc gctgttccag gtgatgctga ccttcgacac cacccagcag 28500 gacgccctcg gcgagctggg ccggctgccc gggatcacga cctcgctgct gcccgtgcac 28560 accgggctgt cccggttcga cctcgtgttc gccttcgacg agcggcggga cgccgcgggc 28620 gggcaggccg gtctcgacct cgcggtggag ttcagcaccg agctgttcga cgccggcacc 28680 gtgcgcgccc tcaccgagcg gctgctgcta ctgctcacgc aggtcgccgc cgatcccggc 28740 gtgcgcctgg gcgacctcga cgtcctcctc cccggcgagc accacgacct gctggtggcc 28800 gccaaccggc ccggcaccgc gcccgcttca ccggcacccg cttcaccgga gcccgcgtca 28860 ccggagcccg cgtcccccgc gccggggacg gccacgctcc ccgagctgtt cgagcggcag 28920 gccgcccggc accccgaccg caccgcgctg accttcgagg gcacctcgct gtcctacgcc 28980 gagctgaacg cgcgcgccaa ccgcctggcc cggctgctga ccgcccgcgg gatcggcccc 29040 gacgcgctgg tcgccctggc cctgccccgc tccgccgaac tggtcgtggc cctgctcgcg 29100 gtggtcaagt cgggcgccgc ctacgtgccg ctcgacccgg gataccccgc cgaccggctc 29160 gcccacgcgc tgtccgactc cgcgcccgcg gccctgctca ccgaccgcgc caccgccggc 29220 cggctgcccg cccacgaggt gccccgcatc gtcctcgacg cccccgcccc ggcggacggc 29280 ggcaccacgg gcggcgaccc ggcggacgcc caccccgcca ccgacctggc gcagggcgag 29340 cgggtcagac cgctggaccc gagggacacg gcgtacgtca tctacacctc cggctcgacg 29400 ggccgcccca agggcgtggc cgtgccgcac ggcaacgtcg tacggctctt ctccgccacc 29460 gcgccctggt tcggcttcga cgagcacgac gtgtggacgc tcttccactc gtacgccttc 29520 gacttctcgg tgtgggagct gtggggtccg ctgctgcacg gcggccggct cgtcgtcgtc 29580 ccgcacgacg tcacccggga ccccgccgcc ttcctcgccc tgctcgcgcg cgaacgcgtc 29640 accgtcctca accagacgcc gtccgccttc caccagctgg ccgccgccga ccgtgagaac 29700 cccaccgaac tcgccctgcg caccgtggtg ttcggcggtg aggccctgga cctgtcccgg 29760 ctggccgact ggtacgagcg gcacgccgag gacgcgcccg ccctggtcaa catgtacggc 29820 atcaccgaga ccaccgtcca cgtctcgcac ttcgccctgg accgggccac cgcggccgcc 29880 tcgtccgcca gcaccatcgg cgtcaacatc cccgacctgc gggtctacgt cctcgacgac 29940 cggctgcgcc ccaccgctcc cggcgtcacc ggcgagatgt acgtggccgg tgcgggcctc 30000 gcccgcggct atctgggccg cccggcgctg accgcggacc gcttccccgc cgacccgtac 30060 gccgccctct tcggcgagcg cggcacccgc atgtaccgca ccggcgacct ggccaggcgc 30120 cgcaccgacg gcggcctcga ctacctgggc cgcgccgacc agcaggtcaa gatccgcggc 30180 ttccgcatcg agcccggcga gatcgaggcc gtgctcgccg cccaccccgc cgtcgacgac 30240 gtggccgtgg tggcgcgcga ggacgtccag ggcgaccccc ggctcgtcgc gtacgtggtg 30300 accggctccg gcgccacggc ccgcgcgctg cacgaccacg cggccgggca cctgcccgac 30360 cacatgctgc cgtcggcgtt cgtcaccctg gacgtgctgc cgctgacgcc caacggcaag 30420 ctcgacacca aggcactgcc cgccccggcc cacgcggggc aggtgaccgg acgcgcgccg 30480 cgcgggccgc gcgaggagat cctgtgcgcc ctgttcgccg aggtgctcgg ggtgccccgg 30540 ctgaccgtcg acgacagctt cttcgacctc ggcgggcact ccctgctcgc cacccggctg 30600 gccggccgca tccgcggcac cctcggcgtg gagctgtccg tgcggcggct gttcgagacc 30660 cccacggtcg ccgggctgtc cgccgccctc gacggcgccg aacggtccgg caccggcccg 30720 acggccgggg agcgcccgga gcggctgccg ctgtcgtacg cccagcagcg gctgtggttc 30780 ctgcaccagc tggagggccc ctcccccacg tacaacatca ccggcgccct gcggctgacc 30840 ggcgacctcg accccggggc gctgcgcgcg gccttccagg acgtcgtcac gcgccacgag 30900 agcctgcgga ccgtcttctc ggaggacggg cacggcgccc ggcagaccgt gctcgacgcc 30960 gccggtgtgc gcttcgagct gccggtcgcc gacgtgagcg aggaccggct ggacgcgcgc 31020 ctcgaggagg ccgcccggca ctgcttcgac ctgacgaccg acatcccggt gcgggcggag 31080 ctgttccggc tcggcgcgcg ggagcacgtc ctgctgctga tggtgcacca catcgccggt 31140 gacggctggt ccctcggccc gctgatccgc gacctggccg ccgcctacac ggcccgcgcg 31200 gcccgtcgcg cccccgactg ggcgccgctg cccgtgcagt acgcggactt cgccctgtgg 31260 cagcgcgccg cgctcgggga cgccgccgac gccaccagcc cggcgggccg gcagctcgcg 31320 cactggaagg aggccctggc cggactgccc gaccggctgg aactgcccgc ggaccggccg 31380 ctgcccgccg tcgcctcgca ccgcggcggc cgggtgccgc tcaccgtccc cgcgcccctg 31440 cacagcggtg tcgcggagct ggccagggag tcccgcacca gcgtcttcat ggtgctccag 31500 gcggcactgg cggcactgct gacccggatg ggcgcgggcg aggacgtacc gctcggcacc 31560 ccggtggcgg gccgcggcga cgacgccgtc gaccaggtcg tcggcttctt cgtcaacacc 31620 ctggtcctgc gcaccgacac cggcggcaac cccaccttcc gcgcactcct cgaccgggtc 31680 cgcgacaccg acctgaccgc ctacgaccac caggacctgc cgttcgagca cctggtggac 31740 gtcctctccc cgaccaggtc gctctcccac aacccgctgt tccaggtgct gctgagcctg 31800 gacaccaccc agcaggacgc cctggccgcg ctctccgcca ccggcctcgg cgtgcggctg 31860 ctgaacgtca ccaccggggt cgccaagctg gacctcgccc tggagatcgc cgagcaccgc 31920 gacgccgacg gcgcccccgc cgggctggtg ggcgcggccg agtacagcgc ggacctcttc 31980 gacgagggca ccgtcacgct gctggtggag cggttcctgc ggcttctgga cgcgctggtc 32040 gcggacccgt cccggcgcat cggcgacgtc gacgtgctcg gcccccggga acgggagcgg 32100 gtcctgaccg agtggaacga caccccccgc cggccggtgc agggcacctt cgccgaccac 32160 gtcgcccggc acgccgccga gcgccccggc cacctcgcgg tcgagacggc cggcgccgcg 32220 gcgcccggcg gcgcgctgac ctacggcgaa ctgaacgagc gcgccaaccg gctggcccgc 32280 gccctgctcg cgcggggcgc gggcccggag cggttcgtgg cggtcgccct gccccgctcc 32340 gccgacctgg tcctctcggc gctcgccgcc ttcaaggcgg gcgcggccta cctgcccgtg 32400 gaccccgcgc accccgccga acggatcacc cacctcgtct cggacgcggc gcccaccctc 32460 atcgtgacca cgtccgccct ggccgcgagc ctcccggaca ccggcacgcc ggtcctcctg 32520 ctcgacaccc ccgagaccgc cgcgaccctc gccgcactcc ccggccacga cgtcaccgac 32580 gccgaccggc cggtaccgct gcgccccgag caccccgcgt acatgatcta cacctcggga 32640 acgaccggcc gccccaaggg cgtcgtcgtc acccacaccg ggctgcccgg cctcctggac 32700 atcttcaccc gcgactgcgc ggccggcccg ggcagcagga tcctccagca cctctccccg 32760 agcttcgacg cctcgttctg ggagctggcg atgggcctgc tcaccggggc caccctggtc 32820 gtggcgccgc cggagaccac gccgggaccg gagctggccg agctggcgac ccggcacgcg 32880 gcgacccacc tgagcctgac cacgtccgtc ctcgggctcc tgccgccgga ctcgctgccc 32940 gacggactga ccctcgtcgt gggcgccgag gccatcccgc ccgagctggt ggagcgctgg 33000 tcgccgggcc gtacgatgct gaactcctac gggcccaccg agaccaccgt ctgctccacc 33060 atgagcggcc cgctgtccgg ccccgccgtc ccgcccatcg gctcccccgt cgccaacagc 33120 gccgtgtacg tgctggacgc ggcgctgcgt ccggtcccgc ccggcgtgcc cggcgagctg 33180 tacgcggccg gagcgcatct ggcccgcggc taccacgacc gccgggcgct gaccgccgaa 33240 cggttcgtgg ccaacccctt cggcgagccc ggcagccggc tctaccgcac cggcgacctg 33300 gtccgctggc ggcccgacgg acagctggag tacctggggc gcgccgacac ccaggtcaag 33360 atccgcggcc tgcggatcga gcccaccgag atcgaggcgg tcatcaccga acgcccgcac 33420 ctggcgcggg cggccgtgat cgtacgcgag gaccggcccg gcgaccggcg gctcgtcgcc 33480 tacgtcgtgc ccgagcccgg cgccaccgtg gacaccgccg aactccgcgc cgcactgcgc 33540 gagaccctgc ccgaccatat gatcccgacc gcgttcgtgg tgctggacgc gctgccgctg 33600 accctcaacg gcaagctgga ccgcaaggcg ctgcccgccc ccgactactc cgcccgcacc 33660 tccggccggg ccgcccgcga cccgcgcgag cggctgctga ccgcactgtt cggcgagatc 33720 ctcggcgtgg agccggccgg cgtcgacgac ggcttcttcg acctgggcgg ggacagcatc 33780 ctctccatcc agctcgtcgc ccgcgcccgc gcggcgggcc tggtcctgtc ggtgcgggac 33840 gtcttcgaac accagacgcc cgcgctgctc gcccggtcgg ccgccgccgc acccgccggg 33900 gaccgcacgg cgcgggactc cgacgtgccc gccgacggcc cggcgccgcg caccccgatg 33960 atgggctggt tcgccgctct cggctccgac ctggccgcgt tcaaccagtc gctggtcctg 34020 cgcgtgcccg ccgccctcga ccccgacacg ctcgacaccg ccctgcgggc cgtgctcgac 34080 cggcacgacg cgctgcgcat gcgggtggcc gacgactgga ccatcgagat cccgccgccc 34140 ggctcggtga ccccggccga ctgcctggtc cgcttcgacg ccgtaggcct cgacgaggcc 34200 gccgtgcgct cggcggtcac cgagcaggca cggacggccc gcgaccggct ggccccggcg 34260 gacggccgca tgctccaggc cgtctggctc gaccgcggcg ccgaccggga cgggctgctc 34320 ctcctggtcg ccaaccacct ggtcgtggac ggcgtcacct ggcgcatcct ggtccccgac 34380 ctggcggccg cctacgcggg cgagaccctc gccccggtgg gcaccccgtg gcggcactgg 34440 gccctgtccc tctccgacct cgccgggcag ccgcgaaccg aggaggagct ggaccactgg 34500 cactcggtcc tcggcgacac cccgcacacg ctccgcctgg accccgcgcg ggacacccac 34560 gcgaccgccg gcgagatcac cgccgaactc gacgcagaca ccaccgaggc cctgctcacc 34620 tgggtccccg gcgtctgcca cgccacggtc aacgacgtgt tcctgagcac cttcgccctg 34680 gccgtcgccg ggtggcggcg cgggcgcggc gaggacgccg acgcacccgt cgtgctcgac 34740 ctggagagcc acggccgcca cgaggaggcg gtcccgggcg tcgaactcag ccgcacggcg 34800 ggctggttca cgtcgatgta ccccgtccgt ctcgcaccac ccgccggcgc ctccggggac 34860 ggatcggcgc tccgcgcgct gaaggccgtc aaggagcagc tgcgcaccgt cccgggcgac 34920 ggcctcggct acggcctgct gcgccacctc aacccccgca cccgggccgc cctcgccgcc 34980 ctgcccctcc ccgagttcgg cttcaactac ctcggccgga tcggccagga gggcaccgac 35040 gaggccccct ggaccatcga gggcggcgac gtcgccggta tcgacggtgc catgccgctg 35100 gcccaccccg tggacgtgaa cgccgtcgcc cgggagaccg ccgacggcac ccggctgcgc 35160 gcccgctgga cgtactcccg cacagcgctg gagcccgagg acacccagcg gctggccgac 35220 acctggttcc ggctgctgcg ccgcctcgtc gaggaggccc ggcagcccgg cgcgggcggc 35280 ctcaccccct ccgacatcgc tcaccccgcc ctcgcccagg acgagatcga ggacctggag 35340 cacaccgtcc ccggcctcca ggacatcctg cccctcgccc ccctccagga gggcttcctc 35400 ttcctcaacc tgtacgacga gaacgcccgc gacgtctacg tcggccagct cgccttcgac 35460 ctggagggct ccttcgacgg cacccgcatg cgcgcggcgg ccggggccct gctgcgccgc 35520 cacgccaacc tgcgggccgg gttccggcag acggcgaccg gcacgtgggt gcaggtcgtg 35580 cccgccgagc tcgaaccgga ctggcgggag tgcgacctga ccgaccgcgc cgacgaggcg 35640 gaacgggacg cggaggccgg gcggctggcg gccggggacc gcgaacgccg cttcgacctc 35700 accagcccgc cgctgatgcg cttcaccgcg atccggctgt ccgccgaccg cgtccggctg 35760 gtgatgacca accaccacat cctgctcgac ggctggtcca tgcccctgct ctggcaggaa 35820 ctgaccgagc tgtacgtctc cggcggcgac cccgtgagcc tccccccggt ccgcccgtac 35880 cgcgaccacc tggcctggct cggcgcccgc gaccgggacg ccgcccgcga cgcctggcgg 35940 cggtccctgt ccgggctcga cgaggccacc ctcctcgccc cggacgccgg cccggccgag 36000 gcggcaccgc tgggcatccc gttcggcctg gaccgtgacg ccacggcggc cctgtccgcg 36060 tgggcgcggg gtcggggggt gaccatgaac acggtggtcc agggtgcctg ggccctcgcg 36120 ctggcccagg ccaccggacg cgacgacgtc gtcttcggcg ccaccgtctc cggccgcccg 36180 cccgagctgc ccggcgtcga gtccatgatc ggcctgttca tcaacaccct gcccgtccgc 36240 gcccgcctcg accaggccga acccctcggc gacctcttcc gccgcctcca gaacgaacag 36300 gcccgcctcc tggaccacca gtggcccgga ctcgccgaca tccagcactg ggccggacac 36360 ggcgaactct tcgacaccgc catggtcttc cagaactacc cggtgagcgc cgacacgacg 36420 agccgacagc tcgacggact gcgggtggcc ggttacgacg cggtcgagag caccgacttc 36480 gccgtcaacc tcgtcgccca cacccgcgac gacgccctgc ggctgcgcct cgactaccgc 36540 gcggacgcct gcgccggcga cctggtccgc tcactggcgg accggatgct gcgggtcctg 36600 gaagcactgg tcaccgactc ggaccgtccc gtggcccacc tggacaccct cgacccggcc 36660 gtacgggagc gggtcctggt ggagtggaac ggggccccga cccagcttcc cgggacaccg 36720 ctgcacgaac tgatcagcga gcaggcccgg ttgacgccgg acgccgtggc ggtggtgtgc 36780 gacgggacct ccctgaccta cgccgagctg gacgggggcg ccaaccagct cgcccggcac 36840 ctgctgggag aaggcctcgg tgcggaggac ttcgtcgcga tcgccctggc caagtcgctg 36900 gacgcggtga tcagcatgct ggccgtgctc aagaccggcg cggcctacct gcccatcgac 36960 ccggactacc ccgccgaacg catcacctac atgctcgacg acgcccgacc cgccctgacc 37020 ctgaccgagc cggtacccgt ggagaggtac acggggcact ccgtcacggc agtcacggat 37080 gaggagcgcc gtagcccctg gtcggcacgc catgccgcgt acatgatcta cacctccggc 37140 tcgaccggcc gccccaaggg cgtcgtcatc gagcaccacg ccctggccac ctacctccac 37200 cgcgcccgca acacctacac cgccatgacc ggtgtgaccg tcctgcactc cccgctggcc 37260 ttcgacctca ccatcaccgc cctgtggacg ccattgacaa gcggcggcac ggtccacctc 37320 accagcctcg aagagtcgga cacgcaaccg agcctgatca aggccacacc cagccacctc 37380 cccctgctca ccacactccc cgagacggcg tccccgtccc acaccctcat cctcggcggc 37440 gaagccctcc acaccgacca cctcgtcacc tggcggaccc agcaccccgg cgttcagatc 37500 atcaacgcct acggacccac cgaatccacc gtcaacatca ccgaccacca cgtaggcgaa 37560 gacacccctg acggtcccgt ccccatcgga cggcccttcg ccaacaccca ggtctacgtc 37620 ctcgactcgg ccctgcgccc cgtcgccccc ggcgtcaccg gagagctgta cctcgccggt 37680 gaacagctcg cccgcggcta cctcggccgc cccgcgctga ccgccgaacg cttcaccgcc 37740 aacccccaca gcagcacccc cggcgcccgc atgtaccgca ccggtgacct cgcccactgg 37800 aaccaccacg gccacctcac ctacgacgga cgcgccgacc accagatcaa actccgcggc 37860 caccgcatcg aacccggtga gatcgaagcc accctcaccg cacagaccgg catcacccaa 37920 gccaccgtcc aactccgtga ggaccagccg ggcgaccagc gcctcgtcgc ctacctcgtc 37980 gtcaacgact ccaccgaata cgacgagaaa accgtgcgcg acgcactcac gagcgcactg 38040 cccgactaca tggtccccag cgcactcgtc accctcgacg ccctccccct cacccccaac 38100 ggcaaactcg accgcaccgc cctccccgcc cccgcctact cggcatccac cgccggacga 38160 gcacctcgca ccccccgcga agaagtcctc tgcaccctct tcgccgaagt cctcggcgtc 38220 gacctcgtca ccatcgacga caacttcttc gacctcggcg gacactccct cctcgccacc 38280 cgcctcgtct cccgcacccg caccgcactc ggcgtcgaac tgtccatccg gcagctcttc 38340 gagacgccga ccgtggcggg tctcgccgag gccctcgacg cgtcgggcac cgtccgcacc 38400 gcgctcaccg cgaggccgcg ccccgagcgc atcccgctct cctacgccca gcaacgcctc 38460 tggttcctcc accagctcga aggaccatcg gcgacctaca acaccgtgct cacgctgcgg 38520 ctcggcggcg cgctcgacgt ggacgccctg cgcgcggcga tcagtgacgt cgtcgcccgg 38580 cacgagagcc tgcggacggt cttcaccgag gacgagcgag gcgcgtacca gatcgtgctg 38640 cccgtggagg ctgcctcgac gcccttcacc gtcgtcgacg tggccgagga ggagatcggc 38700 gaccggctcg acgaagccgt cggccactgc ttcgacctcg cccaggaact tcccgcgcgc 38760 acctcgctgt tccgggtgtc ggagcgggag cacgtactgc tgctcctcat ccaccacatc 38820 gccagtgacg cctggtcccg cgccccactg gcccaggacc tcaccgccgc ctacgcggcc 38880 cgcgtccgca gcgaggcgcc catgtgggcc ccgctcaccg tccagtacgc cgactacgcg 38940 ctctggcagc aggagatcct cggcgacgac accgatgccg acagcctcgc cggccgccag 39000 ctcgcctact ggaaacagca gctcgccggc ctgcccgaac agctcgacct ccccaccgac 39060 cggccccgac cggcggtcgc ggggtactcg ggggaccgtg ttccgttcac cgtgccgacg 39120 gagctgcaca cgcggctgac ggagctggcg cgcgccacca acaccagtgc cttcatggtg 39180 atccaggctg cggtcgccgt cctgctcacc cgtctgggcg ccggtgagga catcccgatc 39240 ggcacccccg tcgccggacg cacggacgac gccgccgacg acctgatcgg gctcttcatc 39300 aacacgctgg tcctccgcac cgacacgtcc ggtgatccga ccttccgccg actcctcgac 39360 cgcgtgcggg acaccgacct ggccgcctac gcgcaccagg acctcccctt cgagcggctg 39420 gtcgaggcgc tgaacccggc acgcacgctg tcccatcacc cgctcttcca ggtcctgctg 39480 acgttcaaca acacggacca cgaaggcgcg ctgaaggaca tctccgagct tccggggctc 39540 accgtcgcac ttcgggaggt ccagcggacc tcgtcgaagt tcgacctctc cttcgggttc 39600 gcggagtcct tcgacacgtc tcgtcggcca caaggcatcg aagcggcact ggacttcagt 39660 acggaacttc tcgaccgccg gtccgcccag gcgatcgcgg accggttcct gcgggtgctg 39720 gaagccgtca ccacagcccc ggaccggccg atcggcgccg tcgagctgat ggacccggcc 39780 gagcgggagc gggtcctggt ggagtggaac ggggccccga cccagcttcc cgggacaccg 39840 ctgcacgaac tgatcagcga gcaggcccgg ttgacgccgg acgccgtggc ggtggtgtgc 39900 gacggcacca ccctgaccta cgccgagctg gaccggcgcg ccaaccagct cgcccggcac 39960 ctgctgggag aaggcctcgg tgcggaggac ttcgtcgcga tcgccctggc caagtcgctg 40020 gacgcggtga tcagcatgct ggccgtgctc aagaccggcg cggcctacct gcccatcgac 40080 ccggactacc ccgccgaacg catcacctac atgctcgacg acgcccagcc ggccctgacc 40140 ctcaccgcgc ccataccgcc cgcttcgtac gacagccggc ccaccagcga gatcaccgat 40200 gtggagcgcc gtagcccctg gtcggcacgc catgccgcgt acatgatcta cacctccggc 40260 tcgaccggcc gccccaaggg cgtcgtcatc gagcaccacg ccctggccac ctacctccac 40320 cgcgcccgca acacctacac cgccatgacc ggcgtgaccg tcctgcactc cccgctggcc 40380 ttcgacctca ccatcaccgc cctgtggacg cctctcaccg ccggcggcac ggtccacctg 40440 accagcctgg aggaggctga ggtccagccc agcctgatca aggccacacc cagccacctc 40500 cccctgctca ccacactccc cgagacggcg tccccgtccc acaccctcat cctcggcggc 40560 gaagccctcc acaccgacca cctcgccacc tggcgcaccc agcaccccgg cgcccagatc 40620 atcaacgcct acgggcccac cgaatccacc gtcaacatca ccgaccacca cgtaagcgaa 40680 gacacccctg acggtcccgt ccccatcgga cggcccttcg ccaacaccca ggtctacgtc 40740 ctcgactcag ccctgcggcc cgtcgccccc ggcgtcaccg gagagctgta cctcgccggt 40800 gaacaactcg cccgcggcta cctcggccgc cccgccctca ccgccgaacg cttcaccgcc 40860 aacccccaca gcagcacccc cggcgcccgc atgtaccgca ccggcgacct cgcccactgg 40920 aaccacgacg gccacctcac ctacgacgga cgcgccgacc accagatcaa actccgcggc 40980 caccgcatcg aacccggcga gatcgaaacc accctcaccg cacagaccgg catcacccaa 41040 accacggtcc aactccgcga agacaccccc ggcgaccaac gcctcgtcgc ctacctcgtc 41100 gtcaacgact ccaccgaata cgacgagccc acccttcggg acgccctggc cagcgcactc 41160 cccgactaca tgcgcccctc cgcctacgtc accctcgacg ccctccccct cacccccaac 41220 ggcaaactcg accgcaccgc cctccccgcc cccgcctact cggcatccac caccggacga 41280 accccccgca ccccccgcga agaaatcctc tgcacactct tcgccgaagt cctcggcgtc 41340 gacctcgtca ccatcgacga caacttcttc gacctcggcg gacactcgct tctcgccacc 41400 cgcctcgtca gccgcgcccg caccgcactc ggcgtcgaac tgtccgtgcg gcagttcttc 41460 gagacgccga cgatcgccgg gctctcgggg gcgttcgacc gggccggccg tgcgcgggcc 41520 gcgctcacgg cgaggccgcg ccccgagcgc atcccgctct cctacgccca gcaacgcctc 41580 tggttcctcc accagctcga aggaccatcg gcgacctaca acatccccac caccctccgc 41640 ctcaccggca ccctcgacac cgacgccctg caatccgcgc tcaacgacct cctcgcccgc 41700 cacgaaagcc tgcgcaccac ctacaccgag gacggcgaag gcccccgtca ggtgatccac 41760 gcctgggagc ccggaatgct gccgctcggc gtggtcgaca ccggggaggg cgagctggac 41820 gcgatgctct ccgcgggggt tcatcacgcg ttcgacctca cggcgggcat cccggtgcgg 41880 gccacgctgt tccggatctc ggagcaggag cacgtactgc tgctcctcat ccaccacatc 41940 gccaccgacg cctggtcccg caccccgctg ggtcacgacc tcgccgccgc ctactcggcg 42000 cgctgtgcgg gcgacgtgcc ggcgtgggag ccgctgcccg tgcagtacgc cgactacgcg 42060 ctctggcagc gggaggttct cggcgacgaa ggcgacgccg acgcccccgc gggcaggcaa 42120 ctcgcctact ggacacggca gctcgccgac ctgcccgagc agctcgacct ccccaccgac 42180 cggccccggc cggccgtggc gagccaggac ggcgaccgcg tcgccttctc gctcgacgcg 42240 gacctgtacg tgcggctgac cgagctggcc agggccaccc actcgagtac gttcatggtg 42300 gtgcaggcgg cgctcgccgt actgctgacc cggctgggcg cgggcgagga catcccgatc 42360 ggcaccccgg tcgccggacg caccgacgac gcgacggaga acctggtcgg cttcttcgtg 42420 aacacgctcg tcctgcgcaa cgacaccagc ggcaacccca ccttccggga gctgctggag 42480 gagacgcgcc gcaccgacct ggccgcctac gcgcaccagg acctcccctt cgagcggctg 42540 gtggaggcgc tgaacccggc ccgtactctg gcgcaccacc cgctcttcca ggtgatgctg 42600 atcctgagca cggcggagac ggacccggac gcctcgctgg cactgccggg actgcgggtc 42660 ggcgcggagc gcagccggct cggggcggcc aaggtcgacc tggcgttcgc gctcgccgag 42720 gtccgggacg gtgagggccg gagcaccggg ctgacgggcg cgctggactt ccggaccgac 42780 ctgttcgacc gttccacggc ccggtccctg gtggagcggt tcgtgcggac gctggaggcg 42840 gtcgtcgccg atcccggtgt gcggctgtcc cgggtgccgg tgctgaccgg gtccgaacgg 42900 cgctcgctgc tcgaccgggg gaccggtccc ctgctggagg ggctggacgc gacgctgccg 42960 gaactgttcg cggagcaggc gctccggacg cccggggcac cggcgctggt gcggggcggg 43020 acgacggtgt cgtacgccga actcgacctg cgcaccaacc ggctggcccg gctgctgcgg 43080 cagcaggggg tgcggccggg cacgccggtg gtcatgctga tggagcggtc gcccgcccat 43140 gtcgtggcga cgctggccat cgccaaggcg ggcggcgcct acgtgcccct gcacgacacg 43200 tatcccctcg accggatgcg gcacgtggtg gcggacaccg ccgcgacgct gatcctcacc 43260 gaccgggccg aggcggcgcg ggccgggcag ctcggcgcgc gggtgatggt ggtcgacgag 43320 ttcggcgccg ccccgtccgg ctcggaggcc gacgcggccc ccggcaccgg caccggcacc 43380 ggcaccggct cgcgctccgg gtacgtcgac gatgctccgg aggtgggcct gcgcccgcag 43440 gatctcgcgt acgtgatgta cacctccggg tccaccgggg tgccgaaggg cgtcgcggtc 43500 acccaccgcg gggtcgtgga cctggtccgc gaccactgct ggcggccggg cgtccacgag 43560 cgggtgctgc tgcacgcccc gcacgcgttc gacgtgtcct gctacgagat gtgggtgccc 43620 ctggtctcgg gcggaacggt cgtcgtggca ccgcccggac acctggaccc ggccgcgatc 43680 accgacctga tcaccgctca cgacatcacc gcgatccacc tcaccgcggg cttcttccgg 43740 gtcgtcgcgg aggaggcacc ggagtgcttc gccggtgtgc gggaggtgct gaccggcggc 43800 gacgtggtct cgccagccgc ggtggcccgg gtcctcgcgc accacccgcg gatcgtactg 43860 cgtcacctgt acgggccgac cgagacgacg ctgtgcgtga cgcagcacga ggtcaccgcg 43920 ccgtacgagg cccgcggcag cctgccggtc gggcgggcga cggggaacac ccgggcctac 43980 gtgctcgacc ggtacctcca gccggtgccg gccggcgtgc cgggcgagct gttcatctcc 44040 ggctccggtc tggcgcgcgg ctacctggac cgtcccgacc tgacctgtga gcggttcgtc 44100 gccgatccgt acggcgggtc cggcgagcgg atgtaccgca cgggcgacct ggtccgctac 44160 aacgcggcgg gcgaactgga gtacctggcc cgcgccgacg accaggtcaa gatccgcggc 44220 ttccgggtgg aactgggcga gatcgaggcg gtcctggcca cgcgcccgga gctggcccag 44280 gccgccgtcg tcgtccgcga ggaccggccc ggcgaccggc gcctggtcgg ctacgtggtg 44340 gccgcggcgg gccgggacgg cgaggtcgac ccggacgcgc tgcgcgcctt ctcccgccag 44400 gcgctgccgg actacatggt gccgtcggcg ttcgtggtcc tcggcaccct gccgctgacc 44460 gccaacggca aactggaccg caaggcgctg cccgcgcccg actacggggc ggcgtccacc 44520 gggcgggccg cccgcacccc tgccgaggag ctgctgtgca cgctcttcgc ccaggtgctc 44580 ggcctgtccg cggtgggcgt cgacgacggg ttcttcgatc tgggcggcga cagcatcctg 44640 tccatccagc tcgtcagccg ggcccgcgcc gccggactcg ccctcgccgt ccgcgacgtc 44700 ttcgagcacc agtcgacggc ccggctggcc gccgcgctga cggaccggga cgacgcggcc 44760 tccgtgccgg aggccgaagc ggtgccgccg tacggtcccg ccccgctgac ccccgtgatg 44820 gcccgcatcg ccgaactggg cctgggcgga gacgacttca accagtcggt cgtggtgtcc 44880 ctgccgcccg cggtggaccg ggaccggctc gtcccggccc tgcaacgtgt gctcgaccac 44940 catgacgcgc tgcgcctgcg cgtcctgccc gacgggagca cggaggtacg cgccccgggc 45000 agtgtgccgg ccgcggacgt cctgagcgtc gtcacgcggg cccccggcgc caccggcgag 45060 gcgcgcgacg ccctgctcgt ggaggcggcg tgcgccgcac gggaccggct cgcaccggcc 45120 gagggccgca tgctccaggc ggtcctggtc gacggcacgg acgacacgga cggcacgggc 45180 gggacctccg gggcggacgg cgtgctgatc ctggtcgccc accacctggt ggtcgactcg 45240 gtgacgtgga gcatcgtcgt accggacctc gccgcggcct accggggcga ggagcccgcc 45300 ccggtgggca cctcgtggcg gcagtgggcc acctccctgg cacggctggc caccgacccc 45360 cgcgtcgagg cggagaccgc ccactgggag cacacgctca ccggggcggg caccctgcgg 45420 ctggaccgcg gccgcgatct ccagggcgac gccggacgca tcagcctcga cctggccccg 45480 cacacgaccg aggccctgct cacgcgcctg cccgggggcg tcaacgcgag cgtgcacgac 45540 gtcctgctga ccgccttcgc gttcgccgtc gccgggtggc ggcgcggacg cggcgaggac 45600 ccggacgcgc ccgtcgtgct cgacctggag agccacggcc ggcacgagga ggcggtgccg 45660 ggcgccgaac tcagccgcac ggcgggctgg ttcacggccc tccacccggt gcggctggct 45720 ccggacgtca ccgactgggc gcggctgcac caggacggcg acgcgctccg ggacggcctc 45780 aagcaggtga aggaacagtt gcggtccgta ccgggcgacg gcctcggcca cggcttgctg 45840 cgccacctca accccaccgc tgggccccgc ctcgcacgcc ttcccgagcc cgacttcggc 45900 ttcaactacc tgggccgccg ggtcaccccg gccaccggca ccccggaacc gtggaccgtc 45960 acgggcggcg gcctcgccgc ctcgcggccc acggcgccga tggcccacgc ggtggagctg 46020 agcgccgtcg tccacgaggg ggcggacggc ccccgactgc gcgcggagtg gacctacgca 46080 cgccgcctgg tccccgatca cgacgcccgc cgcctggccg agcaatggtt ccgggcgctg 46140 gaagccctgg tggagcaggc cgaccgggcc ggcaccggcg gcctgacccc gtccgacgtg 46200 accctcggct cgctcagcca gtccgagatc gaggaattcg agtccgacct tgagtccgag 46260 tgggagattg agcagtgagc cagcaaccga cccgtgcgcg cggcaagatc gaggacatcc 46320 ttccgctctc cccgctgcaa gagggcttcg tgttcctcgg gctgctgcac accgaggggc 46380 ccgacctcta catcggccag gtggccttcg acctggaggg ccccttcgac ggcgcccgga 46440 tgcgcgaggc ggcccgggcg ctgctgcgcc ggcacgccaa cctgcgcgcc gggttccggc 46500 agcgcaagaa cggggcctgg gcccaactgg tcctgcgcga cgtcgacctg ccgtggcagg 46560 acgccgacct gagcacgctg tccgaggagg agcgccgggc ggaggccgac cggctcgcgg 46620 ccgccgaccg tgcccgccgt ttcgacctgg gccggccccc gctgctgcgc ttcaccgcca 46680 tccggctgtc cgccgaccgc gtccgcctgg tgatgaccaa ccaccacatc gtgctggacg 46740 gctggtccat gccggtcctg ctgcgcgaac tcatggcgct ctacgccgcc gagggtgacc 46800 cctccgcgct cccccgggtc cgtccctacc gcgactacct ggcctggctc gacgcccgcg 46860 accgggacgc cgcccgcgac gcctggcggc ggtccctgtc cgggctcgac gaggccaccc 46920 tcctcgcccc ggacgccggc ccggcgtcga ccgctccctc gcaggtgtcc ttcaccgtgg 46980 actccgaggt cagcggcgcc ctgtcggcct gggctcgggg ccagggcgtg accatgaaca 47040 cggtggtcca gggtgcctgg gccctcgcgc tggcccaggc caccggacgc gacgacgtcg 47100 tcttcggcgc caccgtctcc ggccgcccgc ccgagctgcc cggcgtcgag tccatgatcg 47160 gcctgttcat caacaccctg cccgtccgcg cccgcctcga ccaggccgaa cccctcggcg 47220 acctcttccg ccgcctccag aacgaacagg cccgcctcct ggaccaccag tggcccggac 47280 tcgccgacat ccagcactgg gccggacacg gcgaactctt cgacaccgcc atggtcttcc 47340 agaactaccc ggtcgaggag ggcgacctca ccgcccccgc cgacccggac cggctccggg 47400 tcgcctcggc cgacatcaag ggcggcacgc acttcgccgt caacgtcgtc gcgacgatgc 47460 gcggcgccga actgtccttc cgcgtcgact accgacccga cctctacgac gaggcgtacg 47520 cccgcgactt cggccgacgg atgctacggg tactggaaac cctgatctcc gacccggacc 47580 gtcccgtggc ccacctggac accctcgacc cggccgtacg ggagcgggtc ctggtggagt 47640 ggaacggggc cccgacccag cttcccggaa cgccgctgca cgaactgatc agcgagcagg 47700 cccggttgac tccagacgcc gtggcagtgg tgtgcgacgg cacctccctg acctacgccg 47760 agctggacgg gcgcgccaac cagctcgccc ggcacctgct cgaacgaggg ctcggagcag 47820 aggacttcgt cgcgatcgcg ctgcacaagt ccctggacgc cgtcaccagc atgctggccg 47880 tgctcaagac cggcgcggcc tacctgccca tcgacccgga ctaccccgcc gaacgcatca 47940 cctacatgct cgacgacgcc cgaccggcgc tcaccctcag ggagcccgta ccggcggctg 48000 catacggtca ccggcccacc gacgacgtca cggacgcgga acgacggacg ccctggtcgg 48060 cactccatgc cgcgtacatg atctacacct ccggctcgac cggccgcccc aagggcgtcg 48120 tcatcgaaca ccacgctcta gccacctacc tccaccgcgc ccgcaacacc tacaccgcca 48180 tgaccggcgt gaccgtcctg cactcacccc tggccttcga cctcaccatc accgccctgt 48240 ggacgcctct caccgccggc ggcacagtcc acctgaccag cctggaggag gctgaggtcc 48300 agcccagcct gatcaaggcc acacccagcc acctccccct gctcaccaac ctggcagcca 48360 cggcatcccc gtcccacacc ctcatcctcg gcggcgaagc cctccacacc gaccagctga 48420 ccgactggcg cacccagcac cccggcgccc agatcatcaa cgcctacgga cccaccgaat 48480 ccaccgtcaa catcaccgac caccgcctcg acggcacgga agaaggcccc gtccccatcg 48540 gacggccctt cgccaacacc caggtctacg tcctcgactc agccctgcgg cccgtcgccc 48600 ccggcaccac cggagagctg tacctcgccg gagaacaact cgcccgcggc tacctcggcc 48660 gccccgccct caccgccgaa cgcttcaccg ccaaccccca cagcagcgtt cccggcgccc 48720 gcatgtaccg caccggcgac ctcgcccact ggaaccacca cggccacctc acctacgacg 48780 gacgcgccga ccaccagatc aaactccgcg gccaccgcat cgaacccggc gagatcgaaa 48840 ccaccctcac cgcacagacc ggcatcaccc aagccaccgt ccaactccgt gaggaccagc 48900 cgggcgacca gcgcctcgtc gcctacctgg tcacctccac cggatacgac gagaacaccg 48960 tgcgcgacgc cctggtcagc gcactgcccg actacatggt ccccagcgca ctcgtcaccc 49020 tcgacgccct ccccctcacc cccaacggca aactcgaccg caccgccctc cccgcccccg 49080 cctactcggc atccaccacc ggacgaaccc cccgcacccc ccgcgaggaa atcctctgca 49140 ccctgtactc ggagatcctc tcggtgaaca ccgtgggcat cgacgacagc ttcttcgacc 49200 tcggcgggca ctccctcctc gccacccgcc tggtgagccg catccgcacc accctcgggc 49260 gggagctgcc gatccggcag cttttcgaga cgccgaccgt cgctggcctc tcccgtgccc 49320 tggacacgtc cggcaccctg cgcaccgcgc tcaccgcgag gccgcgcccc gagcgcatcc 49380 cgctctccta cgcccagcaa cgcctctggt tcctccacca actcgaagga cccaccgcca 49440 cctacaacat ccccaccacc ctccgcctca ccggcaccct cgacaccgac gccctgcaat 49500 ccgcgttcaa cgacctcctc gcccgccacg aaagcctgcg caccacctac accgaggacg 49560 atcagggcgc ccagcagatc gtgttgcccg tggaggccgt cgcgacgccg ttcgccgtcg 49620 tcgacgtggc cgcggaggac gtggcggaac gggtggccga ggcggcggcg cacgccttcg 49680 atctgggcgc ggagatcccg gtacgggcgc ggctgttccg ggtctcggag cgggagcacg 49740 tcctgctgct gctcgtgcac cacatcgcca gtgacgcctg gtcccgcggc ccactggccc 49800 aggacctcac cgccgcctac accgcccgct gcgccgacga cgcacccgcc tggcagcccc 49860 tccccgtcca gtacgccgac tacgccctgt ggcagcagga gatcctcggc gacgacaccg 49920 accccgacac cctcgccggc cgccagctcg cctactggaa acagcagctc gccggcctgc 49980 ccgaacagct cgacctcccc accgaccggc cccggcccgc caccgccgac cacaccggcg 50040 accgcgtcac cttcaccgtc cccgccgacc tgcacacccg tctgaccgaa ctcgcccggg 50100 agaccaacac cacggcgttc atggtgatcc aggcggcgtt ggcggcgttg ctgacgcggc 50160 acggcgcggg cgaggacatc ccgatcggca cccccgtcgc cggacgcacc gacgacgcca 50220 ccgaccacct catcggcttc ttcgtcaaca ccctcgtcct gcgcaccgac accagcggca 50280 accccacctt ccgcgacctc ctcacccgag tccgcgacac cgacctcacc gcctacaccc 50340 accaggacct ccccttcgaa cgcctcgtag aagccctcaa ccccacccgc tccctcaccc 50400 accaccccct cttccagacg atgctcaccc tgcacaacac gcagggcacg aagacggacc 50460 ggttcgccgg gctggctgcg gaggtggtgg cgtcggagtc ggtgtcggcg cgcttcgacc 50520 tgtcgttcgc gctggccgag cacttcggtg ccgaccattc ctgcgcgggc atgagcggcg 50580 gcgtcacgta cagcacggcg ctcttcgacc gtgccacggt gcgggacctc gccgaccggc 50640 tggtgcggtt gctcgcggcg gcggtggcac acccggggcg gtccgtgggg cagttggaaa 50700 tcatggacgc ggccgaacgg cggctggtcc ttcaggagtg gaacgacacc gcggccgagc 50760 cgccggccgc gtcggtgacc gggctcttcg agcggcaggc gcggcggtcg ccgggggcga 50820 cggccctgga gttcggcgag gtgcggctgt cctacgcgga gctgaacgcg cgcgccaacc 50880 ggctggcccg gcatctcgtc gcgcggggcg cggcgccggg ccggttcgtg gccgtggcgc 50940 tgccccgctc ggcggagctg gtcgtgacgc tgctggcggt cctcaagtcc ggggccgcct 51000 acctgccgat cgacccgcac tacccggccg accgggtgga gtacatgctg gccgacgcgg 51060 ggcccgcgct cacggtgacc gaaccggtgg cggaggccgg gctgtcgggg tacggggacg 51120 cggacctcgg ggcggacgag ctgcggggcc cggtccacgg ggcgcatccg gcgtacacga 51180 tctacacctc gggttccacg gggcggccca agggcgtggt ggtgccgcgc ggggcgctgg 51240 acaacttcct ggccgacatg ggccggcggt tcacgccggg gtccggtgac cggctgctcg 51300 ccgtgaccac ggtgggcttc gacatcgcgg gcctggagat cttcctcccg ctgctgcacg 51360 gcgcggtgct ggtgctcgcc gacgaggaga ccgcgcgcga cccgcacgcg ctgctgcacc 51420 gggtgtcggc gtcggggatc accatggtcc aggcgacgcc gagcctgtgg cagggggtcg 51480 cggccgtggc cggggacgag ctggccgggg tgcgggtgct ggtgggcggg gaggcgttgc 51540 cgtccgagct ggcgcgggcg ctgacggacc gcgcccgctc cgtgacgaac ctgtacgggc 51600 cgacggaggc gacgatctgg gcgacggcgg ccgatgtcgc cgagtccggg ccggtcatcg 51660 gccggccgct cgccaacacc tcggcctacg tgctggactc ggcgctgcgg ccggtcccgg 51720 tcggtgtgcc gggcgagttg tatctggccg gggagcagtt ggcgcagggt tatcacctgc 51780 gtcccgcgct gacgtcggag cggttcaccg ccgacccgta cggcccggcc ggtacccgga 51840 tgtaccgcac gggcgacctg gtgtgccggc gccgggacgg tgcgctgcgc tatctgagcc 51900 gggtggacca gcaggtcaag ctgcggggtt tccgtatcga gctcggggag atcgaggcgg 51960 agctgtcccg gcatccggcg gtggccgagt ccgcggtgac ggtgcgcgag gaccggccgg 52020 gcgaccggcg gctggtcggg tacgtcgtac cgaagggtcc ggagggaccg gcgggtccga 52080 caggtccggt gccgagcgcg cgggagttgc gggagcggct gcgcggacgg ctgccggagt 52140 tcatggtgcc gacggcgttc gtggtgctcg acgcgctgcc gctgacgccg aacaggaagc 52200 tggaccgcaa ggcgctgccc gctccggagt acgacggcga gccggtgggc cgggggccgc 52260 gggatccgcg cgaggagatc ctgtgcgcgc tgttcgccga ggtgctgggc gtcgcccggg 52320 tcggcatcga cgacggcttc ttcgacctgg gcgggcactc gctgctcgcc acccggctgg 52380 tcagccgcat caggacggcg ctgggcgtcg aactgtccgt gcgccagttc ttcgagacgc 52440 cgacgatcgc cgggctctcc ggcgccctgg accgggcggc gggcgcgcgg gcgccgctgg 52500 cggcccggcc gcgtccggag cgggtcccgc tgtcgccggc gcagcagcgc ctgtggttcc 52560 tgcaccagtt cgagggcccg tcggcgacgt acaacatgcc gacggcgctc cggctgtccg 52620 gtccggtgga ccgggcggcg ctggagcggg cgatcggtga cgtgctggtc cggcacgaga 52680 gcctgcggac cgtgttcgcg gcggacgacg gggggtcgtg gcaggtcgtg ctgcccgccg 52740 accgggccgt cggccgcctg gacgtggtcg acgtgaccgc cggggaggtg gcggagcggg 52800 tcggcgaggc ggcccggcac gccttcgacc tgacggccga catcccgttc ctggcccggc 52860 tgttccgcgt ctcggacacc gagcacgtcc tgctgctgct catccaccac atcgcgggcg 52920 acggctggtc gatggccccg ctggcccgtg atctcacggc cgcgtacgcg gcgcgctgcg 52980 cgggcgcggc accggactgg gagccgctgc cggtgcagta cgccgactac gcgctgtggc 53040 agcgggaggt cctcggcgac gagtccgacc ccgacagcgt ggcggcgcgg cagctggcct 53100 actggaagga cgccctggcg gggctgccgg agcagttgga gctgcccacc gaccggcccc 53160 gcccggcgac cgccggatac accggcgacc gcatcgcgtt cacggtgccg acggcgctgc 53220 acgcgcggct gacggagctg gcgcggtcca cgcactccag cctgttcatg gtggtccagg 53280 cggcgttcgc cacactgctg acgcggctgg gggcgggcga ggacattccc gtcggcacgg 53340 cggtcgcggg gcgcaacgac gccgccaccg aggatctcgt cggcttcttc gtgaacacgc 53400 tggtgctgcg caccgacacc ggcggcaacc cgaccttccg cgagctgctg ggccgggtgc 53460 gcgagcgcga cctggccgcg tacgcgcacc aggacgtgcc gttcgagcgg ctggtggagg 53520 cgctgaaccc ggcgcgcagt ctggcccacc acccgctgta ccaggtgatg atcaccttca 53580 acaacacggc cggtgcgggc gaccgcaccg cgcccgcctc cccggacacc ccggacgtgt 53640 ccgggcaggc cggagcgctc ctgaacgcga cccggatgac ggccggtacc ggggtggcca 53700 agttcgacct ggcgctgacc ttcggcgagc ggcacgatcc gtcgggcggt cccgcgggca 53760 tgcgcggttc gctggagtac cgcacggagc tgttcgaccg ggagaccgcg gagtcggtga 53820 tctcgcggct gctcggggtg ctgggctcgg tcaccgccga cccggaccgg ccgatcggcg 53880 ggatcggcct gctggacccg gccgagcggc gccaggtgct gcgggagtgg aacgacaccg 53940 cgcgcccgca gcgcgagggg accctgcccc ggctgttcga ggagcaggtc gccaggactc 54000 cgcgccgccc ggcgttctcg gccgccggga cgacgctgac gtacgccgag ctgaactcgc 54060 gtgccaaccg gctcgcccat ctcctcgcgg agtccggggc gggcccggag caggtggtgg 54120 cgatctcgtt gccgccgtcg gtggagatgg gcgtggcggt gctcgcggtg ctgaagacgg 54180 gggccgcgta cctgccggtc gacccgggca gtccgcgcga gcggatcgcc accatggccg 54240 aggacgcggc gccggtgtgc gcgctgacga cgtccgcggt cccggccggg gtgttcccgg 54300 cggagctgcc ccggctgctg ctcgacgacc cggacgtcac cgcccggctg gcggcgcagc 54360 ccgcgcacga cctgacggac gaggaccgca cgcagccgct gtcgccgtgg aacgcggcgt 54420 acatcatcta cacgtcgggc tccacgggcc gccccaaggg ggtgctcgtg gagcaccagc 54480 cggtgctgaa ctacctggcg gtgtcggcgg agctgtaccc gggcgtggcg ggcaacgcac 54540 tgctgcactc gccgctctcc ttcgacctga cggtgacggg tctgttcgcg ccgctgctga 54600 acggcggctg cgtgcacctc gcggacctgg aggagctgca cgcgcgggcg ctggacggcg 54660 aggtgcccga cctgccgcag acgacgttcc tgaaggcgac gccgagccat ctgccgctga 54720 tcaccgggct gcccggggtg tgcgtgccgg acggggagct ggtcctgggc ggcgagtcgc 54780 tgaccggccg cgcggtgcgg acgctgctcg cggcgcatcc gggggcgcgg gtcctcaacg 54840 agtacggtcc gaccgagacg atcgtgggct gcacgacctg gcgggtcgag gcgccggacg 54900 acctcgcgga cggtgtgctg accatcggcc gcccgttccc caacacgcgc atgctggtcc 54960 tcgacccgta cttgcagccc gtaccggccg gggtgccggg cgagttgtac gtgtccgggg 55020 tgcagctggc gcgcggctat ctgaaccggc ccgggcagag cgcgtcccgg ttcgtcgcca 55080 accccttcga ggggccgggc gagcggatgt accgcaccgg cgacatcgtg cgctggaacc 55140 ggcggggtga cctggagttc atcagccggg tcgacgacca ggtgaagatc cgcggcttcc 55200 gggtggagct gggcgaggtc gagtcggccc tgtcgcggca gccgggggtg ccggaggcgg 55260 tggccgtggt gcgcgaggac cggccgggcg accggcggct ggtggcgtac ctggtgaccg 55320 gagccggacc ggtgccggtg ccctcggacg aggagctgcg ggagcggctg cgcgagacgc 55380 tgcccgacta catggtgccg tcggcgttcg tgcgcctgcc ggagctgccg ctgaccggca 55440 acggcaaact ggaccggggg cggctgcccg caccggacta cgcggccgcc ggcacgggcc 55500 gggccccggt cacggcgcgc gaggagctgc tgtgcgcgct gttcgccgag gcgctgggcc 55560 tggagtcggt cggtgtcgac gacggcttct tcgacctggg cggcgacagc atcctgtcca 55620 tccagctggt cagccgggcc cgcgcgaagg gcctcacgct ctccgtgcgg gacgtcttcg 55680 agcaccagag cgtcgcccgc gtcgccgagg cactcgaact cgccgaggcg caggccgccg 55740 acggcgcggc gggggcgtcg gcgggtgccg taccgggagc ggcggaagag gaggcagcgg 55800 cgagcgggcc ggtgcccgcg acgccgatca tggggtggtt cgccgcgctg ggcgggccgg 55860 tcgcgccgtt caaccagtcg gtggtggtgt cggtgcccgc ggacctggac gcggagcggc 55920 tggtggccgc cctcggggcg ctcctggacc ggcacgactc gctgcggctg cgggtcgccg 55980 cggactggtc catgtccgtg cccgagcccg agcccggcgg cacggacgcc gccggtctcc 56040 tcacgcgccg cgcggccggg gacgtcgacg acgccgggct gcacgctctg ctggccgagg 56100 cgggcgccgc cgagcgcgac cggctgtccc cggccgacgg gcggatgctg cgggcctgcc 56160 acgtcgaccg tgggccggac cggccggggc tgttggtcct ggtcgcccac cacctggccg 56220 tggacgcggt cagctggcgg ctgctcgtgc cggacctggc cgccgcctac gagggccgcc 56280 cgctcagccc ggcgggcacc ggctggcgcc ggtgggcgtc ggcgctgcgg gacctggccg 56340 gctcccccgt caccgaggcc gagacggacc actggctgga cgcggcccgc ccggccgccg 56400 agccggcgga cccggtactg gatccggcgc gcgacaccca cgcccgctcg gggcaggtcg 56460 tcctcgacct cgacccggac accaccgacg ccctgctcac ctgggtgccc ggggtgttcc 56520 gggcggagat caacgacctg ctgctcaccg cgttcgggct ggccgtcgcc gactggcggc 56580 gcgaccgggg cgcccggggc acggcgcccg tcacggtgga cctggagagc cacggccgcc 56640 acgagcacct ggtgccgggc gccgacctca cccgcaccac cggctggttc acctcgatgc 56700 acccggtgcc gctgcacccc gaggtcgacg acccggactg ggccgaggtg tgggacggcg 56760 gggcagcggc cgggcgggcc ctgaagcggg tcaaggagca actgcgcgcc gtcccgcgcg 56820 acggtgtggg ccacggcctg ctccgtcacc tcaacccgcg cacccgggac cgtttcgccg 56880 ccctgccgac accggcgtac ggcttcaact acctgggccg ccacaccggc ggccggggcg 56940 gcggcgcacc gggcggcggc gccgggcccg agccgtggag cgtgctcggg cggggcgtgg 57000 cggggcagca ccccgacacc ccgctggcgc acccggtgga actggtcgcg ggcgcccacg 57060 acaccgacgc ggggcccacg ctgcacagcg tgtggacgta cgcggacgcc gtgctgtccg 57120 agaccgaggt gcggcgcctg ggcgagggct ggttccgggc cctgaaggcg ctggtcgagc 57180 acgccggccg gcccgaggcg agcggtctga ccccctcgga cgtctccctc acctcgctca 57240 gcgaggacga catctcccga ctcgagagcg aatggggttc cctctgatgg ccaagtccgg 57300 cttggaagac atcctgccgc tgtccccgct ccaggagggg atgctgttcc acaacctctt 57360 cgacgaggag gaactggacg cctacaacgt ccaggtcttc atcgacctgg agggcggcac 57420 ggacccggag cggctgcgcc gggccgggca ggcgctgctg gagcggcacg ccaacctgcg 57480 ggccgccttc cggcacgagg ggctcaagcg cccggtgcag ctcatccccc gccgggtcgt 57540 cctgccctgg ggcgaggagg acctgtcggg cgtcgccgaa ccggagcggg aggcggcggc 57600 ggagcgggtc gccgagcggg accgctggac gcgcttcgac ctgtcccggc cgccgctgat 57660 ccgcttcacc ctggtccggc tcggcccggc ccgtcaccgg ctgctgctga cgctccacca 57720 catcctggcg gacggctggt ccatgccgat cctgctgcgc gagctgatga ccctgtacac 57780 cgtccacggc gacggtacgg ccctgccccg ggtgcgcccc taccgcgact acctgggctg 57840 gctcggcggc cgggaccggg acgccgcccg gcaggcctgg acggaggcgt tcgccgggct 57900 cgacgcgccg agcatcgtcg cccccggccg gggcgcgctc accgcggcgc ccgagcggat 57960 cgacttctcc gaggacgagg cggcgagcgc cgcgctgacc cggttcgccc ggtccaacgg 58020 gctgacggtg aacacggtga tccagggctg ctggggactg gtcctgtccc atctgacggg 58080 ccgggacgac gtggtgttcg gcgtgaccgt cagcggccgc ccgccggagc tgcccggtat 58140 cgacaccatg gtcggcctgt tcatgaacac cctgccgctg cgggtgcggc tgcggcccgc 58200 cgagacgctg accgggttcc tgcgccggct gcagggcgag caggcgcggc tcatcgacca 58260 ccagtgggtg ggcctcgcgg agatccagcg ctgggcgggt tccggcgaac tcttcgacac 58320 ggccatggtg ttcgagaact atccgctcaa ctccagccgc ggccgccccc cgggggccgc 58380 gccggacgcg gacctcccga ccgtcctcgg ggtccgttcg aaggaccaga tgcactaccc 58440 gctgggtctg ctggccctgc cccgcgagac cctgcggttc tcgctgggct atctgccgca 58500 ggtcttcgac ccggcgcggg tcgaggcggt gatcgccgcg ttccgccggg cgctgcgcac 58560 cgtcctggac gccccggaca cccgggtcgg cgcggtcgcg ctgctcgacc cggaggtgcg 58620 gggcaccgtc ctggagaagt ggagcggctc ggacgacgtg cggcccgcag agcggttcac 58680 cgacctgttc gaggagcagg tggcgcgcac ccccggcaag acggcgctga tcgcccccga 58740 cgggcggctg acctacgccg aactcgacgc cgccgccaac cggctggccc gtcgcctggt 58800 cgagctgggc gtcggcccgg aacggcacgt ggcggtcgcg gtggggcgcc gcacggaact 58860 ggtggtcggc atgctggcgg tgctcaaggc gggcggcgcc tatgtgccgg tcgacccgga 58920 gtacccgccg gaccgcatcc gccacatgat ccaggacgcg gaccccgcgc tcgtcctcac 58980 cacctccgac gtggacgacc ggatcggcga ggagtgctgc gggccgctga cgttcgtcat 59040 ggacgacccc aacaccggaa cgtcgctggg caggcactcc gggacggctc tcaccgacgc 59100 cgaccgcgcg gcgccgctgc tgccgggcca tccggcgtac gtcatctaca cctcgggcac 59160 gacgggccgc cccaagggcg tcgtcgtcga gcaccgggcc ctgtcggcgt tcgtgcggca 59220 ctgccggtcc tcccaggcgc cggacatctc ggggctgtcc gtgatgcagg cgtccgcgtc 59280 cttcgaccag agcgtcggct cgctgcacgc cccgctgatc agcggcggct gcgtccggct 59340 gacggatctg cgcgccctcg ccgagacggc cgggtccgaa cccggcttcc accgtgccac 59400 cttcatgaag ggcaccccgt cgcacctggc gctgctggcc accatgccgc cggaggtcgc 59460 gccctcgggc accctgaccc tgggcggcga ggagctgcgc ggggagatcc tggcaccctg 59520 gcgcgaggcc gcgggggacg tgacggtggt gaacgtctac gggcccaccg aggccaccgg 59580 tcactgcctg gagcactgga tcgccccgga ccgcacggtg gagccgggcc cggtgccgat 59640 cggcaccccg cacgaggggg tgcgggtgta cgtcctcgac tccgcgctgc gcccggtcgc 59700 accgggtctg gacggcgagg tgtacctggc gggcgtgcag ctggcgcgcg gctacctggg 59760 ccgcggcggg ctgaccgccg agcggttcac ggccgacccg ttcggcgcgc cgggcagccg 59820 catgtaccgc acgggcgacg tcgcgcactg gaacgaagcg ggggagctgg tcttcgccgg 59880 gcgcgcggac cggcaggtca agctgcgcgg gtaccgcatc gagctgggcg agatcgaggc 59940 cgccgtcgcg ggcgggccgg gtgtgcgcca ggccgcggtc gtcctgcgcg aggaccggcc 60000 gggcgaccag cggctggtgg cctacgtcgt cccggacccc ggccactggg acgaggccgc 60060 cgcccgtgcc cggctggccc tgtccctgcc ggacttcatg atgccctcgg ccttcgtcgc 60120 cctggacgcc ctgccgctca gcccgaacgg caagctggac cgggcggcgc tgcccgcccc 60180 gacgtacacc ggccggaccg cgggccgggc accgcgcacc cccgccgagg agatcctctg 60240 cgacctgtac gcggaggtcc tgtcgctgcc gggcgtcacc gtcgacgacg acttcttcga 60300 cctcggcggt cactccctgc tcgccacccg gctcgtcagc cgggtccgca ccacgctggg 60360 ggccgagctg tccatccggc agttcttcga ggcgccgacc ccggccgcgc tcgccgtggt 60420 gctcgccggg gcgggccggg cgcgggccgc gctcaccgca cggccccgtc ccgagcgcct 60480 cccgctctcc tacgcccagc agcgcctgtg gttcctccac ctgctcgaag ggccgagccc 60540 cacctacaac atcccgacgg tgctccggct gagcggaccg ctgcgcccgg acgcgctgcg 60600 cgcggcgctg ctggacgtgg tcgggcggca cgagagcctg cggacgacgt tcaccgagga 60660 cgagcggggg gcccggcagg tggtgcaccc cgccgacggg gtccggccgg tcttcgagac 60720 ggccgagtcc acggaggccg actacgaggc cgacctcgca cgggcggccc ggcacgcctt 60780 cgatctgggc gcggagatcc cggtacgggc gcggctgctg cggctgtcgg agcgggagca 60840 cgtcctgctg ctgctcgtgc accacatcgc cagcgacgcc tggtcccgcg gcccactggc 60900 ccaggacctc accgccgcct acaccgcccg ctgcgccggc gacgcacccg cctggcagcc 60960 cctccccgtc cagtacgccg actacgccct gtggcagcag gagatcctcg gcgacgacac 61020 cgaccccgac accctcgccg gccgccagct cgcctactgg aaacagcagc tcgccggcct 61080 gcccgaacgg ctcgacctcc ccaccgaccg gccccggccc gccaccgccg accacaccgg 61140 cgaccgcgtc gagttcgccc tccccgccga cctgcacacc cgtctgaccg aactcgcccg 61200 ggccaccgac acgaccctct acatggtgct ccaggccgcc ctcgcgacgc tgctcacccg 61260 gcacggcgcc ggtgaggaca tcccgatcgg cacccccgtc gccggacgca ccgacgacgc 61320 caccgaccac ctcgtcggct tcttcgtcaa caccctcgtc ctgcgcaccg acaccagcgg 61380 caaccccacc ttccgcgacc tcctcacccg agtccgcgac accgacctca ccgcctacac 61440 ccaccaggac ctccccttcg aacgcctcgt agaagccctc aaccccaccc gctccctcac 61500 ccaccacccc ctcttccagg tggtgctgtc gctgcgcagc accgcaccgc ggcgggcgga 61560 cggggagggc gcgccggcgc tgccgggcgg gctgagggtg agcggcacgg gcggtgcggc 61620 ggcgacggcg gccaaggtcg acctcgggtt ctcggtgacg gagcgccggg cggccgacca 61680 cacccccgac ggggtggcgg gcgtcctcga cttccgcacc gacctcttcg accgcggcac 61740 cgcgcagggt ctggtggacc ggctggtgcg ggtgctcgcc gacgcggccg cccaccccga 61800 ccggccgctg agccgcatcg acgtgctcgg accgcgggag cggcaccggg tcgtcgagga 61860 gtggaacgcg acggcgaagg ggctcgcccc ggccaccctg cccgagctgt tcgagcggca 61920 cgtgcgggag cgccccggcg ccgaggcggt ggtcgccggc gacacgtcgc tgagctacgc 61980 ggagctgaac gcgcgcgcca accggctggc ccggctgctg gtggcgcggg gcgcgggccc 62040 cgagcggctg gtggcgctgg cgctgccccg ctcggccgaa ctgcccgtcg ccgtcctcgc 62100 ggtggccaag gcgggcgccg cctacctgcc gctggacccg gcccacccgg cggagcggat 62160 cgcgggcacc ctcgacgacg cggcaccggt cgcgctgctg accacggccg cggtggccgc 62220 cggcctcccg gacacggacg tgcccaggct gctccttgac gaggagcccg cggccggcgg 62280 tggcgaggac gccgccgacc tcaccgacgc cgaccggctc gcgccgctgc tgccggggca 62340 tcccgcgtac gtcatctaca cctccggcac caccggccgc cccaagggcg tcaccgtgac 62400 gcactcgggc ctgcccgccc tgctggacat cttcacctcg cagctggacg tcgtacccgg 62460 cagccgcgtc ctgcaccacc tctcccccgc cttcgacggc gggttctggg agctggcgat 62520 ggggctgctg accggtgcgg ccctcgtcgt cgtggagccc ggcaccgtgc cggggcccgc 62580 cctggccgcg ctggcggtcc gccaccgggt cacccacgcg gcgatcaccc ccgcggtgct 62640 ccagctgatc cccgagggcg cgctgcccgc cggcacgacc ctggtcgtcg ccgccgagac 62700 ctgcccgccc gaactggtcg cccgctggtc cgcgggacgc ctgatgcgca attcctacgg 62760 gccgacggag accacggtct gcgccaccat gagcgccccg ctggcgggcg cggccgtccc 62820 gccgatcggt aggccgatcg ccgacaccgc cgggtacgtc ctggacgacg cgctccagcc 62880 ggtgccgccg ggcgtgcccg gggagctgta cgtgcgcggg cccggactcg cccgcggcta 62940 cctgggccgc ccgtcgctga ccgcgggccg cttcgtggcg tgcccgttcg ggccggcggg 63000 cggcgtgatg taccgcaccg gcgacctggt acgccaccgc gcggacggcg acctggagta 63060 cctgggccgc accgacaccc aggtcaagct gcgcggcatg cgcgtagagc cggccgagat 63120 cgaggcggtg acggcgggcc tgcccggcgt ggcgcaggcg gccgtgctgg tccgcgagga 63180 cacgcccggc gaccgccgcc tggtcggcta cgtcgtgccg gacgccgggg cgagtgtgga 63240 ccccggcgcg ctgcggcagg cgctgcgcgg ctcgctgccc gagtacatgg tgcccgccgc 63300 cctcgtggtc ctcgacgcgc tgccgctcac caccaacggc aagctggacc accgtgcgct 63360 gcccgccccg gagtaccgca ccgtcgaggg ccgctcgccg cgcaccccgc gcgaggaggc 63420 cctgtgccgg ctcttcgccg aggtcctcgg tctggagctg gtcggtctcg acgacggctt 63480 cttcgacctg ggcggccact cgctgctggc gatccggctc gtggagcggg tccgtgccga 63540 gctgggcgag gagctgggcg tgcgcgacct gttcgccgct cccacggtcg ccgacctggc 63600 ggtgcggctc gcggcgcgcg gcggccggga gccgatggag cggctgctcc cgctgcgtgc 63660 cgccggtacc gcccggccgg tgttctgcgt ccaccccggt tccggcatga gctggtgcta 63720 ctccggcctg gtgcgccacc tgccgcccgg tatcccggtg tacggcctcc aggccgccgg 63780 actcgacggc gacgggccgc tgcccgcgac gcttcaggag atggccgccg agtacgcgga 63840 tctggtccgg cagacgcagc ccgagggccc gtaccggctg ctgggctggt cgctcggcgg 63900 caacgtggcc ttcgccatgg cccgcgaact ccgcgcccgc gggcaggagg tggagctgct 63960 ggccttcctg gacgcctatc cgcgccgggc gggcgcgggc ccggaggccc cgctggccga 64020 ggtgttcgcg cacaacctgc gcgacgccgg gttcgacgtc gccgaggagg agctcaccgg 64080 cggccgcttc cccacggccc gctaccgcgc gttcctgaac gccgccgggg acccgatggg 64140 ccgcctggac gaggccgaac tggccgcggt cctggaggtg ttcatgaaca acgcggccct 64200 gatgcgcggc cacacccccg gcacctacga cggcgacgtg ctggtgctgg cggccgagcg 64260 ggcggacggc gacaagctgg cccgccgcgg cgccgagtcg tggcgcccgc acgtgcgggg 64320 ccggatcgaa cgggtcggtg tcgacgccga ccacctcggc ctcgtgcagt ccgacgccgc 64380 cctcgccgtc atcggccgcg cgctggccgg ccgcctggac ccggcgacgg gccacgcggc 64440 ttccgcagca gttcccgaga ccgaaggagt caccgccatg aacccctcgc ccgagcccgc 64500 cccgtcgccc gagtcgctcg attcgaccga ggtcgcctga gccatgcccg tcctcaccgt 64560 caacggcatc aggatcaact actacgacga cgcgcccccg gcgggtgcgc agaacgcgcc 64620 cgccgtgctg ctcgtcatgg gctcgggcgg cagcggccgg gcctggcacc tgcaccaggt 64680 gcccgcgctg gtcgccgccg ggttccgggt gatcagcttc gacaaccggg gcatcgcgcc 64740 gagcgaggag tgccccgggg gcttcggcat cgacgacctg gtcgccgaca cggcggccct 64800 cgtcgaggaa ctgcggctgg ggccctgccg ggtggccggc atctcgatgg gcgcgcacat 64860 cgcccaggag ctggccctgt cccggcccga cctcgtggac cggctggtcc tgatggcgac 64920 ccgggcccgc ccggacgcgc tgcgcgaggc gctgtgccgc gcggagatgg agctgtacga 64980 ccaggggatc aggctgcccg ccgcctacga ggcggtcgtg caggccatgc agaacctgtc 65040 gccgcgcacc ctcgacaacg acgtgcaggc ccgcgactgg ctggacgtgc tggaactgac 65100 ccggcgctcc ggtgcgggct accgggccca gctcggggtg cgggtggacg gcgaccggcg 65160 ggaggcctac cgcggcatcc gggccgccac ccgcgtcgtc gccttccagg acgacctgat 65220 cgccccgccc cacctgggcc gggaggtggc cgacgcgatc cccggcgccg agtacgagct 65280 ggtgcccgac tgcgggcact acggctacct ggagtcgccg gacgcggtga acaagagcct 65340 cgtcgaattc ctgcgccggt gaaggagaac ccgttgaaga ctgagtccga tgtccagacc 65400 ggtgcgccga cggccgccga cggcgcgctg atcgcgctgg cccgtgaggt gtgcccaggc 65460 ttcgcccccg gggaggtcgt ctaccgcagc cgcacctcgc tggtggtggg cggcgagctg 65520 gacggcgtcg aggcgctggc caaggtgcgc acgcccgact ggcggcgcca gtgcctgcgc 65580 gagatcgaca cctacgacct gttcgacgcg gtgcccccgc cggtgccggt gccgcggcgg 65640 ttcgcctccg accgggagcg ggccgtgctg gtcatggagc ggctcacggg agaggtgctg 65700 gcgccggacc ggttcccggt cactccggtc tcccgggagg acctggccgg ggtgctggag 65760 gccgtggagc ggctgcggca ctggcggccc gcggcggccg gcgcgtgggc ggtggactac 65820 cgggggatgc tggagggggt gcacgcccag ggcgtcttcg acgacgggca ctgggcggac 65880 ctgctccggc tcctcgaact gtccggtgcg ccccgcgagt tcggccacgg cgacctggtg 65940 ctggcgaacg tggtccgcag ccggggccgg caggtcctga tcgactgggc gagcagcgcc 66000 ctgtacctgc ccggactcga cctggcccag ctctggatgc tcctcggcga cgtccccggg 66060 gcgcgggccc gcatcgaggt ggaggtggcc gaccgcgccg acgaccggga cgggatgatg 66120 ccgttcctgg tgaacctgac gctgctgctg taccgcgagc gccgcgccca ccggcggttc 66180 accgacgacg cctcgcgggc ccgggcggtg gggctcgacg ccgcctggga gctgacccgg 66240 caccgcgtcc ggcagtgcct ggcgacggcc ggctgaccgg cccggcgcac acgaaggggc 66300 ctcccggtga agtgcgccgg gaggcccctt cgtgtggggg gggaaggcgg tctactggat 66360 gagcagttgg tggctggcca gctcccggta gagggggctg gtgccggtga gttcctcgtg 66420 ccggcccgcg gcgacgaccc ggccgtgctc caggacgacg atctggtcgc tgtccacgac 66480 ggtggacagc cggtgggcga ccacgagcag cgtccggtcg gcggtgacgg tgccgatggc 66540 ctcccgcatc agggcctcgt tgcgggcgtc gaggttgctg gtcgcctcgt cgagcagcat 66600 gatcggcggc gcggccagga aggtgcgggc cagcgccagg cgctgccgtt cgccgccgga 66660 cagcaggacg ccgccctcgc cgacctcggt gtccaggccc tgcggcgccc gctcgatcac 66720 gcccatgagg ttgaccgagc gcagcacctc ccgcatgtcg tcgtcggtgg cgtcgggcgc 66780 ggcgagggag aggttgtcgc ggacggtgcc ggcgaggacc ggcgccgact gctcgacgta 66840 gccgaggcgt ccgcgcagtt cgcggcgggg caggtcgcgt acgtcggtgc cgccgacccg 66900 gacggtgccg gaggtgacgt cgtagaaccg ttccaccagc gacaggaggg tggacttgcc 66960 cgctccggag gggccgacga gcgcggtgcg ggtgccgcgg gggacggcga gggagacgtc 67020 ccgcaggacc gtctcgccgt cgccgtagcc gaagctgacg ccctcgaact cgatcgcggg 67080 cggccgcggt tccgcgtcgg cgggctcggt cccgggccgg gtgcgttcgc gcaccgtgag 67140 cggtcccgcg acggcgtcgg tctcctgcgg caggtccacc atctcctcga tgcgctggag 67200 ggcgcccagc ccggactgga gccgggagta ggcggtcagc gcgcggccga gcgggaacca 67260 cagcatgaac aggaagagca cgaaggcgac catgtcgccg acctggatgg cgccgctggc 67320 cacccgggcg ccgccgaggc cgaggacgac gaggaacgcc acctggatgg tggtcgaggt 67380 gatcgggttg atcatcgcct ggagccgggc gatgcgcatc ccggcgtggt aggcctgctg 67440 cgcgtacccg tcgacggcct tgccctcgcg ttcctcggcg ccgctggcgc ggatggtgcg 67500 cacggcggag atggcgcgct cgacggcgga ggtcatctcg ccgatccggt cctgggcgtc 67560 gcgggaggcg ccccgcaccc gccgggagag cccgacgacg gcgaggacgc cgagtccgag 67620 gccgagggcg gtggccgcga acagggtggg gtcgatcagg cacatcatga gcgcggagcc 67680 gccgaccatg acgacgttgg tcacggtgtc gaagaggccg gaggtgacca ccgcgcgcag 67740 catggtggtg tcggcgccga cccgggagag catgtcgccg gtgcggcgct ggtcgtactc 67800 ggtgatgggc agccgcagca gccgggccac cagccggcgg cgggcggtca gcacgagccc 67860 ttcggcggcc cgctggagca ggtagtcgcg gaccccgccg agcacggcca ccaccacgag 67920 gacgccgatg agcagggcca ccagccgccc caccggcctg tccgcctcga tgtcggccag 67980 tacgtcccgg gtcagcaccg gctggctgag ggtcagcagg gtgaccacca gggagagcac 68040 cgcgacgatc cccagcgtcg gccagtagcc ctggagatag gggaacaggg agcgcagccc 68100 gaccttgcgg accggcgggg cgggcggtcc gggctccggc gcgttcttcg cgccggtctt 68160 ccgggcgggc ggtcgctccc tggtctgcgt gctcgtcatc gcactcctac tcatgtctca 68220 ctgcgggggc ttggccggtc aggcgggctg cggggccgct ccgagcacgt agccgtcggc 68280 cggccgcatc gcgcgcgagc ggcgcaggtc ggtgagcacg aaggtgcgct ggagccagcg 68340 gtcggtgccg tcgtagcggg gggtgaactc ggtgcggccg tgcacggtga cgcggttgtc 68400 cacgatcgcc agctccccgg gcaggaggcg gtgggtgacg gcggtggcgt cgaagtgggc 68460 ctggagttcg cgcagggcct cggcggcccg ctcggtcacc ggctcggtgg ccgccaggtc 68520 cacccgcagg tcggggtccg aacggtcgcc gaggagtacc ggtgcgggtg cctcctcggg 68580 gccgctcagc tggaaggagg gcggcggcgc ggtgcggaac tccggtgccc acagggcgtc 68640 cacggtggag tcggacagca gcggcagcac ccgccgcacg cacgcggtgc gcaggcccgc 68700 ccggcccgtg gggtcggcgc gcaggcacag cagcatcacg aagtcggggc ggtgctcgtg 68760 gaaggcgttc tcgttgtgga acgtcagcag ggtcgaaccg gcgttgccct ggaactcctc 68820 catgcccggc acggggacga cgtcctgtac gagggcgccg ttcttctccg gcaggaacgc 68880 gccggggtcg ccgagcccgc aggcggtcat cagcagcacg gcggcgccca gcgaggcctc 68940 gcgctgcacg gagccgttga cccgcggggt cggcggcagc cccatggagt cgacgggcag 69000 accgcgcagc acgatcgcgc cgtccggtcc cgagtcccgg cggaatccgg cgaggtcccg 69060 gcgcagggtc gccggccagg cgtgccaggc gttcctggcc gcctcgaccc attcggcgtc 69120 gtcgggccgc ccggtcgcct gcgtggcgag tttccaggcg atctcctcga cgagttccgc 69180 atccgactga tccagcgtca cgtcgtagcg cgacgccggt cccgcggcat tcgcagccat 69240 gggcagagcc tccgtccacc gtcgttttgt gtgtactcgg gacgctatgg gccgtcgtta 69300 tcggccgcgt atcgagtgag catggggaga gatcccggcc agggagagca gcagttcctt 69360 gacctccgtc gcggcgacca actcccccag cggcgcgtcc gggtcggaga ccagcagcac 69420 cggcgcgtcc tcggggcggc cgggcaggcg tccgtggctg ccgcggaccc gggagccgtc 69480 cagggggacg acgttcatgg tgtagcgcag cccgagcttc ttgcgggcca gcgccgccgc 69540 cgcgcggagc cgggccttcg ccggggcgtg gtggtcgaag cccagctcgg ccgggtcgta 69600 gccgggcttg cggtggatct cgacggtgcg ggcgaagtcc ggggcgcggg cgtcgtccag 69660 ccagtagtag taggtgaacc aggcctcggg ccgggcgacg gcgacgagtt caccggcccg 69720 ctcgtggtcg aggccgtgtt ccttcttccc ggcctcgccg agcacctcgg cgacgccgtc 69780 caggccgtgc agcagttcct cgacgcgcgg caggtcggcg gcgtcgcgca cgtagacgtg 69840 ggcgacctgg tggtcggcga cggcgaaggc cctcgacgtc caggggtcca ggtactccat 69900 gccgtcctgg gtgtgcacgg ccagcagccc ggcccggcgc agcgcccggt tgatgtcgac 69960 gggcctgctg accggggtga tgccgtactc gctcagcacc acgacggtga cgccgtcgcg 70020 gcgggcctcg tcgagcagcg gtgccagggt gcggtccagt tcggcggcgg cccggcgggc 70080 ccggcggctg tccgggccga agcgctggag gtcgtagtcg aggtgcggca cgtagacgag 70140 gttcaggtcg ggcttgtggg cgcggtgcag atggcgggcc gcgtcgacga tccagcggga 70200 ggaggcgagg tccgcggtgg gcccccagta gtggaagagc ggaaagggcc cgaggcggcc 70260 ggtcagctcg tcgtgcaggg aggccgggtg ggtgtagcag tcgggctcct tgcggccgtc 70320 ggcgtagtag accggccggg gcgtcaccgt ccagtcgacg tcggcgccca tggcgtacca 70380 ccagcagacg ttggcgacgg tgtagccggg gtgcagcgcg cgggccgcct gccacacctt 70440 ctcgccgccg acgagccggt tgtgctgccg ccacagcagt acctcgccca ggtcgcggaa 70500 gtaccagccg ttgccgacga cgccgtgctc cgcgggcggc cggccggtca gcagcgtgga 70560 ctgcaccgag caggtcacgg cgggcagcac ggtgtccagg cgggcgccgg tgccggcgtc 70620 gcgcagcgcc gagaggcggg gcatgtgggc cagcaggcgc ggggtgagcc ccacgacgtc 70680 cagcacgagc aggcgcttca cggggtgctc tcctccgtca ggccgagggc ggtcagggcg 70740 gagcgggtcc aggcgagttc accggcgatg ccgtcgacga ggccgccgcc gtcgggtgcg 70800 ccgggcagca ccggccaggt gtaggtctcg acctccacgt ggtcggtgag cgcggtcggc 70860 ccgccgagca gggtggtcag cgcggcgacc agttcggggc gggtgctgcg caggggcggc 70920 ggcaggtcgc gctggacggg cacgtggtag tggatccgcc aggccgcgtc gccgttcagc 70980 gcgcccccaa gcgcctcggg caggtcgtcg acggccgacg ggccgcccgg cgcggcctgc 71040 cgcgtctggt gcaggaaccg ccgctcggcg aaggcggcca gcgcggcgcg ggcggccggg 71100 tcggccggcc ggtcggcgtg caccgcgcag gacgcctggg tcttgacgac gggcagcgcg 71160 gcggccagcc gggtcagcgc gggtcccggc tcctcgaagg cgacggcgag gtggcaggtg 71220 tcgacgcaga cgccgagccg ttcggggtcc gcgccggcga gccgtgccac cgcctggccg 71280 gtcgtctcga tcaggcaccc gggctcgggt tcgaacccga cgcgcacggt gcgcccggtg 71340 tccgcgttga gcgccgccag cccctgggag agcaggtcga ggtggcgccg ggcgaggtcg 71400 tcccggcgcg gggtccaggg tgtgcgccag gccagtggca gcgtggagac ggagccgcgg 71460 gcggcgtccg gcggcagcag ctcggccagg acgcgggcgc aggccagggt gtggtcgagg 71520 cggggccgct cggtccagtc gggccggtag acggccttct tgacggtcgg ggcgtggaag 71580 cccgcgtagg ggaaggcgtt gagggtgacg acctcgatgc cgcgcaggtc cagttccttg 71640 cggagcaggt cgagcgcgga ccggtccgcg gccagggccg tcacgaccgg tgccgccagc 71700 cacagtccga ggccgatccg gtcggcgccg agccgttcgc gcaccggctc cccgtagcgg 71760 gccagctggg ccaggacgcc gtcgaggtcc tcggccgcgt ggacgttggt gcagtaggcg 71820 aggtggacgg tggtgccgtc gcggtgccgc aggcgcacgg cccgtcacct ctccccgcgg 71880 cggatcgagc tgccctcgaa ctccgcgcgg acgccggagg cttcggcgcc ctcggggccg 71940 tcgagttcga ggcgcccgct ctgcccgtag aaggcgaccg gattgcgcca cagcacctgg 72000 tcgacgtcgt cctcgccgaa gccggcggcg cgcatggcgt cggcggtgcg gcgggtcttc 72060 agcgggtcgc tgcggcccca gtcggcggcg gagttgacga ggatccgcgc ggtgccgtac 72120 tcgcgcagca gcgcgaccat gcggtcctcg ctcatcttgg tgtcggggta gatcgagaaa 72180 cccatccagc agccgctgtc cgcgacggcg cgcacggtca cctcgttgag gtggtcgacg 72240 acgaccaggc ccgggtcgat gccggactcg cggaccacgt ccagggtgcg gcgggtgccg 72300 ttggccttgt cgcggtgcgg ggtgtgcacc aggacgggca gggcgtgccg cacggcgagt 72360 tcgagctgca cggtgaacgc cttgtcctcc tgcggcgtca tcgcgtcgta gccgacctcg 72420 ccgaccgcca ccacccggtc ccggaccagg tagtcgggca ggacgtcgag caccccggcc 72480 agccgggggt cgttggcctc cttggggttc agggcgagcg cgcagtggtg gcggatgccg 72540 aactgctcgg cccggtaggg ctcccagccg agcagcgcgt cgaagtagtc ggtgaacgag 72600 ctgacgccgg tgcgcggctg gcccagccag aaggcgggtt cgaccagcgc gcggaccccg 72660 gcggcggcca tcgcctcgta gtcgtcggtg gtgcgggacg tcatgtggat gtgcgggtcg 72720 aagatgcgcg tcacgccgtg gcctccgtgg atacgcggtg ggtgtgcagg taggcggcga 72780 cgtcgggcgg gagtgcccgt cccgcggcgc gccgctcggc ggcgaagtcg gccatcatcc 72840 ggtccagttc cgcgtcggcg cgtgcgtcca gcgcggccac caggtccagc gggacgccga 72900 cgaacacgca tttgaggacg gcctgccgga aggcgtgcgc accgagccgg cgggcgccgt 72960 acgggccgac ggcggcggcg atcagcctcg ggtcgttgca ccgcagcgcg tcctcgacca 73020 gcggcagccc caggtccccg aggtcgcccg cggcctccag cagcgacagc gaccgcagga 73080 cggcccgccg ttcgggcccg cccccgatcc ggtacagccg ggagacgacg gccgccagcg 73140 cggcaccgcg caccggaagc gcggcgagca gcagcacgcg cgcggcgtcg tcgacgctcc 73200 accccgcgcc cagccccgta cccgcatccg cacccgcgcc cgcttccgcg ccggcgtcga 73260 gcgcgccccg accgcaccgc cgggcggcga ccgcgaacgt cccctcgacc tcgcccggct 73320 cgcaccgcac cgccgcgcac gcctgctcca gccacgcggc ggcgtccggg gcgagcgcgc 73380 ggtccagggc gccggcgagg gcgtccggca gggaccgggg tccgtcgccg ccggggttca 73440 cgcggccgct ccccgggtcg cggggcgggc gccggcgtcg gccgcgcgca ggaagtccag 73500 ggaccggcgg gccacctcgg gggcggcgtg gctgtgccgg ggcagctcca ccgagaccag 73560 tccgcggtag ccggtggcgg ccagcgcgga cagcacgggc gggaagtcga tctccccgct 73620 gccgaactcc aggtgctcgt gggtgccccg gcgcatgtcc tcgatctgca cgttgaccag 73680 ccggtcggcg acccgccgta cgcagtcggc gaccggctgc ggctccaggc agcggcagtg 73740 cccgatgtcc agggtcagcc ccagcgggtg cgggccgccg agcctgcggc acagttcgtc 73800 gtaggcgtcc agggtgtcca cgaacatgcc gggctccggt tcgaagccca gcacgacccc 73860 ggcccgcgcg gcggcctcga cgacggtgcc gcagccggcc agcagccggt cccagaccac 73920 ctgccggggc gtgtcggcgg gggcggcgcc gctccagaag gacacggcct ccgcgccgag 73980 gtcggcggcg atccgcacgg cccgcagcag caggtcgacc cggcgcccgg cgccctcggc 74040 ggacatcagc accggctggt gcttgcgcca ggggtcgagc acgtaccgcc cgccggtctc 74100 gacgacgacg gccagcccca gccggtccag ccgcgccgcg agccgccgca gccggtgcgg 74160 caggtcgtcg gcgaacgggt cgaggtgccg cgggtccagg gtgagtccga cgccctcgta 74220 gcccagatcc gcgaggacgg ccagggcgtc ctccagcgga tggtcgccga agccgttggt 74280 gccgtacccg aatctcgtac cggcgctcat gtgggggaca cctttctgcc cagtcgtcgg 74340 gcccacggga gggcgcaggc cagcgcggcg ccggcggcgc cgcgtccggc ggtcgcggtc 74400 agcgccgcct ggagcgggat cagcgcgtgg atgccggccg ccaccgcccg ccgcacctgc 74460 ggcgcggccg gactccgcgc ggccgcgagc tgcgccgccg cacccccgta cgcgtacacg 74520 gccgtcaggc ccgcggccag gacccggtcc cgggccggcc gacggcggcc gcgcagcagt 74580 acggcggctc cgaccgcccc gccgacggcg agcgactgcc ggggcaccgc gcggggcgca 74640 ccgctcacct cgtaccggct cagccgggtg accatgccgg tgtgcagggc gacggtggcc 74700 gccgccggca gcgcccggcg cagtccgccc ggtcccgcgc cgcccaggac gttcagcgcg 74760 cgggccgcgg ccatcgcggc cgcaccggcc ggggtgggct tgagcacgag gtcgtacgcc 74820 cagacgacac cggccagggg cagcgccgtg gccaggcccc ggcggccgcg ggacagtgcc 74880 gcgaggccga gcccggccgc ggtgagcccg cagccgaccg cgcgggccgc ggccgggctc 74940 accgccccgg agggcaccgg gcgttcgggc cgctccaccg cgtcgaggtc gcggtccgcg 75000 tagtcgttga gcgccatccc cgcccagtac aggcagaccg acgaggccgt catgccgagc 75060 agtccggggc cgagcggccg ccgggccgcc gccgctccgg cgaggacgtc cccgggcacc 75120 gacagcgcgg ccggggcccg gaccaggcgg gccaggtcgt gcacccgcgg cagcgcactc 75180 acgcgggcgc ccccaccgag cgcgcccagg cggccaggct cgcgtactgc gcggccaggt 75240 cgtgctcggc ggagcccacc gggtccttga agaagaagcc cagctccggc accggcccgg 75300 cgacgcctgc gcggtgcgcg agggccatga accgggccag gtccagcacg agcggcgcgg 75360 ccagcgagga gtcgcagccc tgccacgtga actgaagggt catccgggcc ccgaggaacc 75420 cctcgaacgt cacgtggtcc caggcggtct tccactcccc gaggtcggga acgtggtgga 75480 tgtgcacgcc gccctcgacg gcgtggccca gctccgcctc cagcaccagg cccttggagg 75540 cgttcttgct gaccacccgc tccgggtcgg cgagggtggc cccgtcgccg ccgcccagca 75600 ggttggtgcc ggaccaggag cgcacccgca gcgcccggcg cgcgaacatc ggcgcgagca 75660 ccgacttgac cagggtctcg ccggtcttgc cgtcgctgcc ggcgtagggc aggccctgtt 75720 cccgggcgag ttcgtccagc gcgggcaggc gcgctcccgt cgacggggtg aagtcgacga 75780 aggcgcagcc ggcccgcagc gccgcgtagg cgtacaggga gctgacgggc agcggccgtt 75840 cgccccgcgc cagcgcctcg cgcagggccg ccgccgaggc gtgcgccggg tgcggcacgg 75900 ccggcggctg ggtggaggag acgttcacga cgacgacccg gtccagaccg aggcgctccc 75960 ggaagccggt gaggtcggcg acgatcgccc cggcggccga cgcctggtcc ggggtgccgt 76020 cgccgccctc ctccgtgccc ggcggcgcgg gcctgatctc ggcgtcggcc gcgtcgagtt 76080 ccgcggtcag cacacccggc aggccgcggg gcacgacgcc cgcctcggcg agctgctcgg 76140 cccgtttgac caggccggtg ccgacgacgt cgtggccgcc gaagaccagc tcgtcgaagc 76200 cgggcagcgg cacgccgtcg aaggcctcga gcgcgctcac acagccggtg gccggcacca 76260 gcccggcgcg cagcgcggcg gcgccgacga cggtcgtggt ggccaccgag ccgcgggcac 76320 ccaccagcca gattccggta cgcatgatgt ctcctcctgt ccttgccgtt gtcctcgccg 76380 cggcgccggg tccgtcagct catgccttcg ggcagcgggt aggacaggaa gtcgcggtcg 76440 agccggtgca cgctgcgcgg cagccacttg gcggcctccc gggccacgac ccggcgcggc 76500 agcggctcct tgacctcgaa ctgggagggc ttggcgatgg tctggatcgc ccacgccatc 76560 gcgttgatcg gggccatccg ctcccagcgg tgcctgctga tgtccagcag catcatcgac 76620 cgcatgaaga tgaaccagat gtggtagccg ggcggcgggt tgccgttcat ggtgtgcacc 76680 gggcgctcgc ggcgggggtc gttgagcacg ccctgggcga agtccgcgaa ggcgccgacg 76740 atgccgtggc cgtagggccg gtagtaggtg tcgaagacgc cgagctgggc cttggagagc 76800 acctggagcg ggcccttgat gggggtgacg tactcgatga agttgttcgg gtagtcgctg 76860 gtggcggcca tggccatcca ggcgtcgaag atggcccgct cccagccgtc gccgagcgcg 76920 gtctcgatgt cggtgaacgc ctgctccagc tccgggccca cgttgtagag cgtggtctcg 76980 tcgaacatgt accagagttc gttggcgcgg cggtcgccga gcatgccggg tacgtcgggg 77040 aagtcgtcgt ggccgcggtg cggggtgacg gggcgctcgg cggcaccggc cggagcggcg 77100 cccagcagac cggcgccggc gccgaggccg acggccgcgg caccgccgag ggcggtggtc 77160 atcaggcgcc gccggtcgag gtggttcgac atgggttctc cttggttctc tcgcgcgggc 77220 agggtgggct cgggggtggg ttcagggggt cgcggcgggc tacggcggcg gcagcggtgg 77280 gaggccggcc tcggcgtcgt ggcgctggat ccaggacacg tcctcgacga gggacgacat 77340 cgtgcccgtg gactcggtcc cgtcctcgtc gggccgcagc cgctgggagc cgccgccccg 77400 cgagccgagt tggacccggg tggtgtgcgg cctgcggaca ccctcgtagg cgtccagcgc 77460 ggccgcgatc gcccgccggg cggcgggagc ggaagcggcg gctgcggcgg gagcggaggc 77520 ggcggctgcg gcggatacgg aggccgaggg gtccgggccc gtcggggcgt ccaggcagtg 77580 tgcgaggacc gccgcgtcct cgacggcctg gctgacgccc tggccgtggt ggggcagcat 77640 cgggtgggcc gcgtcgccga gcagggtgac ggcgcccgcg ctccagcggg ccagcggctc 77700 acggtcgtac agcgcccagc gccgggactc ccgcaccgcg gccaccaggg acttgacgtc 77760 ggtgttccag ccgtcgaagc gggcggccag ttcgtccagg tcgcccgggg cgctccagga 77820 ctccaggcgc caccgcgggt cgggcacgac ggcgacgaag gtgaggaacc gcccgccgcg 77880 caccgggtag accagcatgc gggcgtccgg tcccgcccac accaggagcg tgtcaccggg 77940 caggccggga acctggtcgc gggcgacgac gccgcggaag gcgctctggc cggagaagac 78000 ggcggtgtcg ggcccggcga gggtgcggcg caccacggag tgcgccccgt ccgcgccgat 78060 caggacgtcc gcgccggcgg tggagccgtc ggcgaactcc agccggaccc cgcccccggt 78120 ctcggtgaac cgttcgagcc ggtgcccggc ccgcaccgtg ccggagggca gcgactcggc 78180 gagcatggtg tgcaggtcgg cccggtggat cgtgtagtac ggcgccccga actcggcgag 78240 ccattcctcg cccatcggct gccgcaccag ggtgcccccg tgcgaccagt cccgcacctc 78300 catgcccgcg ggccgtacac cgagggcgcg cagccgctcg ccgaggcccc agcgttccag 78360 aaggcggctg ccgttggggc ccaggtgcat gcccacgccc gcttccctga gttccggcgc 78420 ctgctcgtag acgcgtacct cgtggccctt ccgggtcagg gcgagggcgg cggcgagtcc 78480 gccgatgccc ccgccgacga ctgcgatccg cagcttcggc accacgttgt cccttcctct 78540 cgtgcgcctg gttcgtcgct cggtccggtc agctccgctg gtcctggacg ggttccgcgc 78600 ccgaccagac gacggcggcg gagccccagg tcagcccgcc gccgaaggcg gtcaggagca 78660 ggcggtcccc ggagccgata cggccctgcg cggccgcgtc ggccagcgcg agggggatgg 78720 acgcggcggc ggtgttggcc acgtccgcga tgttcgacac cacccgctcc gggggcagcc 78780 gcagccgctt cgccaccgag gtgaggatgc ggaggttcgc ctggtgcccg acgaaggcgt 78840 ccacgtccgc caggtcccag cccgcgtgcg cggcggtgga acgcgccgac tccgccatgg 78900 tggtcacggc acgggtgtag acgtcgctgc cgcgcatggt gaggtacgcg ccgtccggcg 78960 ggatggtgat cagctcgtcg ccggtgccgt cgctgccgag ctcggtgtgc agcacggcgc 79020 ccgggtcgcc ggtgtcgccg cgctccagga gcacggcgcc cgcgccgtcg ccgaagacga 79080 cggcggtgcc ccggtcgtcg gggtccacga tcgaggagta gacgtccgcg ccgatgacca 79140 gggcccggtc gcaggtgccc gcggtgatca tcgcgctggc cacggacagc ccgtacacga 79200 agccggagca cacggcggac aggtcgaacg cggcggcggc ccgcagcccg agccgggacg 79260 ccacccgggg cgcggtggcg gggcagcgcc ggtccggtgt ggtggtggcg aggaggacga 79320 ggtcgcagtc gtcccgtccg gcggacttca gcgcggcggc cccggcggtg acggcgaggt 79380 cccccgtggt ggtcccgggc gacacccggc gccggcgctc gatgccggta cggctgtgga 79440 tccaggcgtg gtcggtgtcc aggtgccgcg acacctcgtc gttgtcgacc acggtctccg 79500 gcagacaggt gcccaccccg gtgacgacgg ccccggcccg accgccgcgc gcggcgctca 79560 cgggcgtact ccggcctgca cggtgccggg ggcctgcacg gtgcccgggg ccggtccggt 79620 acccgggctc ggtccggtac ccgggctcgg gacggtgccg gcatgggccg cggcggtgcc 79680 ggcatgggcc gcggcggcgt gccgttccgc gaagtccggg tgggcgatcg gggcgctgat 79740 caggccctcg ggcacggcca gttcgcgcag cagcgcgtcg gcgtcgaggg gggcgcccgc 79800 cgcctcgtgc cgggccgcct cgaaccccag gagggcgtcc tggtcgagga tcccggcccg 79860 cagggcggcc agcgcgtgtt ccagcacgca gaccgccgcg tactgcgcga gcagccgctc 79920 ggacagcggg gtcgatgcct gccgggccca gtggccgatc gccagcgtct ggtggacggc 79980 acggctccac tgcgcgctgg cctcaccggc gccgtcccgc tccacccggt cgagcaggac 80040 gtcgcagacg gcccgcagca cccggacggc gtccagccgt ccggccccgg cgaccgcctc 80100 gtccagcacc cggtcgaagt cctcgcggtg gcgcagggcg aaccgggtcg cctggtagcc 80160 gaggacggtg ttgtcaccgc cgaaggtgac cgcgatctcg tagtcgtgca gcagcggcgc 80220 gatctggttg gcgtcgtggt agccgagccc gccgcacagc tcccgggtct cggccagcgt 80280 ttgccgggcg tcgccggtgc agccggactt gccgcacgag atcagggcgt gcagcacctg 80340 gtcgcgggcc ggtgctccct cggcgctccg ggccaccgcc acctcggcca gcgccgtcat 80400 ggcgtgccgg gcggccagcg agcgccccac ggccgccgac agccgcatgc ggtagtgctc 80460 gtggccgatc agcggcctgc cgaaggtctg cttgacggcc gcgaaccgcg tggtgatcgt 80520 gcaggcgagc agttgcgcgt acgccgctcc caccgacggg aaaagccgct cgtgggtgaa 80580 ggtggccagg cactcctcga accgccggtg gcgcggcagc ggggaccggt aggtgccgtc 80640 ctcgtcgatc gacgcccagc ggttcatcag cgcggacagc ggcagccggt ggtccgtgaa 80700 ggtcagtacg ccggtctggt tggccgtgac accgcccttc ggctcggccc ggccgatgcg 80760 cacgccgggc agtacggccc cggcctcgcg cagcggtacc cgcagccagt ggtgtccctc 80820 gtcgcgcccg ccgacctcca gccgggccag caccatggcc acgtcgccgg tgtgcaggct 80880 gttgccggtc cacaccttgc tgtcggcggg ccggggcgtg ttcagcacca ggctccgccc 80940 gtgcgggtcg tagaccgcgg tggtccgcac ccgcttcagg tccgagccgg cgaggagttc 81000 ggaaccggcg aagcagtaca tccgctccat cgcgtcgatc tccccagccc aggcgtccag 81060 ttgctccgga ccgccgtggc tgagcagcgc gtcgcccgcg atctggtgcg agaccaggac 81120 gttgagcagg gacaggtcgt acgcgccgat ccagcccatg gtgcgcagga actccgggaa 81180 gcgggcactg tcgccccggc ccagccagag ggagttcgcc gcgaaaccgg cgccgttgag 81240 gagccgcgcc cggcgcagcg tcagcaggct gtagtcgagg acgctcaggt cgtccggtcg 81300 gatggtggcg aactcgggcc cggagaggac acgggccagc tcttcttcgc gttgcgtcat 81360 gggctctcca ggggagggaa gctcggatcc gtggacgccg tggcgtcgtt cagccggcgt 81420 ccagcaccag cgcgcagttg ctgccgccga acccgaagga ggtgctcacg gcgacgttcc 81480 cgtcgtgccg gcgcaccccg ccgaggacca ggtccagctc gggcaggccg gggtcggccc 81540 gctcggtgtg cgcgatcggc ggcagcacgc cggtgcgcag gctgcgcagg gtcagtacgg 81600 cctcgatggc gcccgccgcg ccgagcgtgt ggcccagcag gcccttgttc gcggtgacgg 81660 acgggccgtg cgggaagagg cgggcgatga gccgggcctc cgtcaggtcg ttctgcgggg 81720 tcgaggtgcc gtgcgcgttg acggtggtca cgttccgcac cgacatccgc gccgccgcca 81780 gcgcccgctc cacggcggcc gcggcgcccg caccgtccgg ccggggggcc gtcggatgat 81840 gcgcgtcgga ggtgtcggca tgcccgagca gccgccccag cacctccgct ccccgcgccc 81900 gcgccttggc cggcttctcc atgacgacgg cggcggcacc ctccgacatc acgaagccgt 81960 cgcggtcggc gccgaacggc cgggaggcgt cggtcgcctt ctgttcggac agcgcgccca 82020 tccgggcgaa gccggagacg acgagggggg tgacggccgc gtccgtgccg cagacgacga 82080 ccgtgtcgca gacaccggcg tccagcagcg tcttgccgag cccgaacgcc gaggcccccg 82140 aggcacaggc ggcggccacg gtgtgaccgg gcccggtgat cccgtaccgg gcgccgatgg 82200 tcccggccgc catgttgatc agggcccggg ggtgcaggta cggcgacacc atggccgccc 82260 cctgccgctc cagccgccgg tgctgctcgt cgtgcgtggt cacgcccccg aaggcgctgc 82320 ccacgacgac cccgacccgg ctgccgtccc agctgtccgg gtcgagcccc gactgcgcca 82380 gcgcctccgc cacggccacc agcgcgaacc ggatgaacgg atcggtacgg gcggtcccgc 82440 gcccggtcag ctgccccggc cgcagcgcgg gcacccgcag gctgtgccac gccccggtcc 82500 cggccagcgg ctcggggtca ccgccctcca gggaccgggc tgcgcacatc gcctcccagg 82560 tcgagtcggc gtcggtaccg gccggcgtca ccagcccgac accggtgatg gcggcgggcc 82620 cctcggtcac gccgcttcca gacccgagcc ggccagcagg accacttccc cgacggtgag 82680 atccgcgatc cgcgtctcgt caccgctgag gtccacgccg gtctcctcct tgatccgcac 82740 gatcagctcg gcgacggcca gcgagtccag ctccaggttc cgcagcgagg caccgtccgt 82800 gatctccgcg gggtccactt ccagatcctc ggccagaatc ccgtgcacaa ccgacttggg 82860 gtccgtactc at 82872 //