ID   BGC0000315; SV 1; ; DNA; ; UNC; 82872 BP.
XX
AC   BGC0000315;
XX
DE   Calcium-dependent antibiotic biosynthetic gene cluster
XX
KW   complete genome
XX
OS   Streptomyces coelicolor A3(2)
OC   Bacteria; Actinobacteria; Actinobacteridae; Actinomycetales;
OC   Streptomycineae; Streptomycetaceae; Streptomyces; Streptomyces albidoflavus
OC   group.
XX
CC   MIBiG: Minimum Information about a Biosynthetic Gene cluster
CC   This entry originates from the region between 3519449-3602320 nt
CC   from GenBank ID AL645882.2.
XX
FH   Key             Location/Qualifiers
FT   gene            complement(1..1455)
FT                   /gene="SCO3210"
FT                   /gene_synonym="SCE8.03c"
FT   CDS             complement(1..1455)
FT                   /product="putative 2-dehydro-3-deoxyheptonate aldolase"
FT                   /codon_start=1
FT                   /gene_synonym="SCE8.03c"
FT                   /transl_table=11
FT                   /note="SCE8.03c, aro, probable 2-dehydro-3-deoxyheptonate
FT                   aldolase, len: 484 aa; similar to many e.g. TR:O52308
FT                   (EMBL:AF035756) 2-dehydro-3-deoxyheptonate aldolase from
FT                   Streptomyces sp. fasta scores; opt: 1619, z-score: 1722.0,
FT                   E(): 0, (54.5% identity in 440 aa overlap) and
FT                   SW:AROF_ARATH phospho-2-dehydro-3-deoxyheptonate aldolase 1
FT                   from Arabidopsis thaliana (525 aa) fasta scores; opt: 1457,
FT                   z-score: 1549.2, E(): 0, (48.4% identity in 457 aa
FT                   overlap)."
FT                   /db_xref="GI:4490619"
FT                   /db_xref="GOA:Q9Z4X1"
FT                   /db_xref="InterPro:IPR002480"
FT                   /db_xref="UniProtKB/TrEMBL:Q9Z4X1"
FT                   /translation="MTASDTYTQPRTAPAGTGTAAPGPTGPAADAGRGGWTPGSWRSRP
FT                   AAQQPEWPDPGELRGVEDTLALRPPLVLPDEILDLRRSLAQVAAGEGFLLQAGDCAERF
FT                   GSCTEAGVRGKLRVILQVAILLTYGSGLPVVKVGRIAGQFGKPRSRPTEAVDGVELPVY
FT                   RGDIVNGPEFTAEARRPDAGRLLSAYHHASAALNVLRALTLGGYADLGQVHEWNQEFVR
FT                   RSPAGQRYEKAADDITWALRFMSACGLDTRSQAALHQVQLYTSHEALLPQYEQALIRYD
FT                   EKRRGWFDTSAHLLWIGDRTRRVDGAHVELLAGVDNPVGVKVGPTMGVDDLRELCERLD
FT                   PDRAPGRLVLISRLGAGRGAELLPPLLRAVRDAGHAPVWACDPMHGNTFVSASGYKTRR
FT                   LSDITTEVAEFFAVHREEGLHPGGIHLELTGDDVTECLGGDLDEVLDTHLASRYETACD
FT                   PRLNAAQSIELAFGVARLLRELRGGA"
FT                   /gene="SCO3210"
FT                   /protein_id="CAB38581.1"
FT   source          1..82872
FT                   /strain="A3(2)"
FT                   /mol_type="genomic DNA"
FT                   /organism="Streptomyces coelicolor A3(2)"
FT                   /db_xref="taxon:100226"
FT   cluster         1..82872
FT                   /note="Cluster number: 1"
FT                   /note="Detection rule(s) for this cluster type: nrps:
FT                   ((Condensation & AMP-binding) or (Condensation & A-OX) or
FT                   cluster(Condensation,AMP-binding));"
FT                   /note="Structure image: structures/compound1.png;
FT                   structures/compound2.png; structures/compound3.png;
FT                   structures/compound4.png; structures/compound5.png;
FT                   structures/compound6.png; structures/compound7.png; "
FT                   /product="nrps"
FT   gene            complement(1452..2228)
FT                   /gene="SCO3211"
FT                   /gene_synonym="SCE8.04c"
FT                   /gene_synonym="trpC2"
FT   CDS             complement(1452..2228)
FT                   /product="putative indoleglycerol phosphate synthase"
FT                   /codon_start=1
FT                   /gene_synonym="SCE8.04c"
FT                   /gene_synonym="trpC2"
FT                   /transl_table=11
FT                   /note="SCE8.04c, trpC2, probable indoleglycerol phosphate
FT                   synthase, len: 258aa; similar to many inluding another from
FT                   Streptomyces coelicolor TR:O68814 (EMBL:AF054585) located
FT                   in the trpCBA locus which maps (by hybridisation) to the
FT                   overlap between cosmids 3A3 and 4G6 (269 aa) fasta scores;
FT                   opt: 652, z-score: 740.9, E(): 0, (47.2% identity in 254 aa
FT                   overlap). Also similar to SW:TRPC_PSEAE trpC, probable
FT                   indoleglycerol phosphate synthase from Pseudomonas
FT                   aeruginosa (278 aa) fasta scores; opt: 632, z-score: 718.3,
FT                   E(): 1.1e-32, (43.5% identity in 260 aa overlap). Contains
FT                   Pfam match to entry PF00218 IGPS, Indole-3-glycerol
FT                   phosphate synthases, score 316.20, E-value 3.8e-91."
FT                   /db_xref="GI:4490620"
FT                   /db_xref="GOA:Q9Z4X0"
FT                   /db_xref="InterPro:IPR001468"
FT                   /db_xref="InterPro:IPR011060"
FT                   /db_xref="InterPro:IPR013785"
FT                   /db_xref="InterPro:IPR013798"
FT                   /db_xref="UniProtKB/Swiss-Prot:Q9Z4X0"
FT                   /translation="MSGILAGLVAEAESQTGRRRALRTEAKLTELAAAAPPARDFAAAL
FT                   REPGLAVIAEMKPRSPSKGPLTDDYRPAELARAYQGGGAHAVSVLTHEAGFGGSPDHLA
FT                   VARAACELPVLRKDFVVDEYQILEARALGADALLLIVAALAPARLAALLARTRACGMEA
FT                   LVEVHDEREVDVALEAGADVIGVNHRDLRDFSIDRTLSARLRGRVGTGRVMVGESGVRG
FT                   APDARALEAAGVDAVLVGELLMRAGDPGTTIKGLVG"
FT                   /gene="SCO3211"
FT                   /protein_id="CAB38582.1"
FT   misc_feature    complement(1461..2126)
FT                   /note="Pfam match to entry PF00218 IGPS, Indole-3-glycerol
FT                   phosphate synthases, score 316.20, E-value 3.8e-91."
FT                   /gene="SCO3211"
FT                   /gene_synonym="SCE8.04c"
FT                   /gene_synonym="trpC2"
FT   gene            complement(2225..3232)
FT                   /gene="SCO3212"
FT                   /gene_synonym="SCE8.05c"
FT                   /gene_synonym="trpD2"
FT   CDS             complement(2225..3232)
FT                   /product="probable anthranilate phosphoribotransferase"
FT                   /codon_start=1
FT                   /gene_synonym="SCE8.05c"
FT                   /gene_synonym="trpD2"
FT                   /transl_table=11
FT                   /note="SCE8.05c, trpD2, anthranilate
FT                   phosphoribotransferase, len: 335 aa; similar to many e.g.
FT                   SW:TRPD_AZOBR TrpD, anthranilate phosphoribotransferase
FT                   from Azospirillum brasilense (355 aa) fasta scores; opt:
FT                   924, z-score: 1056.6, E(): 0, (49.5% identity in 315 aa
FT                   overlap). Contains Pfam match to entry PF00591
FT                   Glycos_transf_3, glycosyl transferase family, score 223.70,
FT                   E-value 2.8e-63."
FT                   /db_xref="GI:4490621"
FT                   /db_xref="GOA:Q9Z4W9"
FT                   /db_xref="InterPro:IPR000312"
FT                   /db_xref="InterPro:IPR005940"
FT                   /db_xref="InterPro:IPR017459"
FT                   /db_xref="InterPro:IPR020072"
FT                   /db_xref="UniProtKB/Swiss-Prot:Q9Z4W9"
FT                   /translation="MQRPLTEAEAADAMRVIMRGEATAAQIAAFALAVTVRGASADNLA
FT                   GMARAAQEFATPVPRAGGDLLDTCGTGGDGLNTFNISTAAAIVAAACGVRVAKHGNRSA
FT                   SSACGSADVLEELGVRIDLGAEEAAACLDRTGITFLFAPVFHPAFRHTAGPRRELGART
FT                   VFNLLGPLCNPSGARLRTLGVPSRELVEPMTEVLERLGVTRALVFHSADGMDELSTAAP
FT                   AHLVELRDGRRTTHRFDPAEHGLARSRPGDLAGGDRAVNAAVLRRVLAGGRGPARDVVL
FT                   LNAAAALRVAGVAGTWSDGLRLAASAVDGGAAAGLLDRWAHASWQRADLVEVPA"
FT                   /gene="SCO3212"
FT                   /protein_id="CAB38583.1"
FT   misc_feature    complement(2804..3229)
FT                   /note="Pfam match to entry PF00591 Glycos_transf_3,
FT                   glycosyl transferase family, score 223.70, E-value
FT                   2.8e-63."
FT                   /gene="SCO3212"
FT                   /gene_synonym="SCE8.05c"
FT                   /gene_synonym="trpD2"
FT   gene            complement(3249..3851)
FT                   /gene="SCO3213"
FT                   /gene_synonym="SCE8.06c"
FT                   /gene_synonym="trpG"
FT   CDS             complement(3249..3851)
FT                   /product="probable anthranilate synthase component II"
FT                   /codon_start=1
FT                   /gene_synonym="SCE8.06c"
FT                   /gene_synonym="trpG"
FT                   /transl_table=11
FT                   /note="SCE8.06c, trpG, anthranilate synthase component II,
FT                   len: 200aa; similar to many eg. TR:G4185545 (EMBL:AF108766)
FT                   TrpG, anthranilate synthase component II, from Rhodobacter
FT                   sphaeroides (195 aa) fasta scores; opt: 728, z-score:
FT                   825.0, E(): 0, (60.2% identity in 186 aa overlap). Contains
FT                   matches to Pfam entry PF00117 GATase, Glutamine
FT                   amidotransferases class-I, score 332.60, E-value 4.3e-96
FT                   and Prosite PS00442 Glutamine amidotransferases class-I
FT                   active site."
FT                   /note="smCOG:
FT                   SMCOG1249:carbamoyl_phosphate_synthase_small_subunit
FT                   (Score: 137.5; E-value: 8.4e-42);"
FT                   /db_xref="GI:4490622"
FT                   /db_xref="GOA:Q9Z4W8"
FT                   /db_xref="HSSP:1I1Q"
FT                   /db_xref="InterPro:IPR000991"
FT                   /db_xref="InterPro:IPR001317"
FT                   /db_xref="InterPro:IPR006220"
FT                   /db_xref="InterPro:IPR006221"
FT                   /db_xref="InterPro:IPR011702"
FT                   /db_xref="InterPro:IPR017926"
FT                   /db_xref="UniProtKB/TrEMBL:Q9Z4W8"
FT                   /translation="MSAPTGTRAGAAPRVAVIDNYDSFTYNLVHYVAELGGRPTVFRND
FT                   AVTVAELAGFDLLLLSPGPGTPAGAGICVDAVRALGARLPVLGVCLGHQAVAVAYGGSV
FT                   VRGEQVHGKASAVHHDGGGVFAGLPDPFSATRYHSLVVEPAGLPDELTVTARTADGTVM
FT                   GLRHRTHPVHGVQFHPESVLSPEGKQLIANFLECADD"
FT                   /gene="SCO3213"
FT                   /protein_id="CAB38584.1"
FT   misc_feature    complement(3261..3812)
FT                   /note="Pfam match to entry PF00117 GATase, Glutamine
FT                   amidotransferases class-I, score 332.60, E-value 4.3e-96"
FT                   /gene="SCO3213"
FT                   /gene_synonym="SCE8.06c"
FT                   /gene_synonym="trpG"
FT   misc_feature    complement(3564..3599)
FT                   /note="PS00442 Glutamine amidotransferases class-I active
FT                   site."
FT                   /gene="SCO3213"
FT                   /gene_synonym="SCE8.06c"
FT                   /gene_synonym="trpG"
FT   gene            complement(3848..5383)
FT                   /gene="SCO3214"
FT                   /gene_synonym="SCE8.07c"
FT                   /gene_synonym="trpE2"
FT   CDS             complement(3848..5383)
FT                   /product="probable anthranilate synthase component I"
FT                   /codon_start=1
FT                   /gene_synonym="SCE8.07c"
FT                   /gene_synonym="trpE2"
FT                   /transl_table=11
FT                   /note="SCE8.07c, trpE2, anthranilate synthase component I,
FT                   len: 511aa; similar to many eg. SW:TRPE_PSEPU TrpE,
FT                   anthranilate synthase component I from Pseudomonas putida
FT                   (493 aa) fasta scores; opt: 1173, z-score: 1253.8, E(): 0,
FT                   (44.3% identity in 492 aa overlap). Contains Pfam match to
FT                   entry PF00425 chorismate_bind, chorismate binding enzyme,
FT                   score 529.40, E-value 2.5e-155."
FT                   /note="smCOG: SMCOG1018:isochorismate_synthase (Score:
FT                   385.7; E-value: 6.2e-117);"
FT                   /db_xref="GI:4490623"
FT                   /db_xref="GOA:Q9Z4W7"
FT                   /db_xref="InterPro:IPR005256"
FT                   /db_xref="InterPro:IPR005801"
FT                   /db_xref="InterPro:IPR006805"
FT                   /db_xref="InterPro:IPR015890"
FT                   /db_xref="InterPro:IPR019999"
FT                   /db_xref="UniProtKB/Swiss-Prot:Q9Z4W7"
FT                   /translation="MTTHAAEAPTTDPQGAPGSQKTPDATEAEEAARATVPHRAAAAAL
FT                   AREHDVVPLHQEFLDDSVSPVTAFAQLCGPDEAGFLLESVPVSGGVARYSYVGHRPVPL
FT                   EPTGGDPLTALRSHLARSVAPVPGLPPFHGGVVGYLGYEAARHFEDLPLAAGPPPGLPE
FT                   SAFLAADDLVVFDHATRRVLLMTLYRPARESYDDAVARIVRLNRALRRAPAPAAFSGRP
FT                   LAAATPADHGTQGWTANLTEAQFTERVARAREHIAAGDAFQIVLSRRLSRPLRARPTDL
FT                   YRHLRATNPSPYMYHLSLGGGRHVIGASPELLVKAEGRTVRTRPLAGTRPRHPDPAEDL
FT                   RLERELRADEKERAEHVMLVDLGRNDLGRVTEPGTVRVERLMRVERFSHVMHLSSTVRG
FT                   RLAEGRDALDALRSAFPAGTLSGAPKIRAMEIIAELEPEQRGVYGGALGFVGADGLTDF
FT                   AIALRTMVVADGHVHVQAGAGIVADSDPAAEFRETLHKSRAMLTAVRRAEAAA"
FT                   /gene="SCO3214"
FT                   /protein_id="CAB38585.1"
FT   misc_feature    complement(3872..4663)
FT                   /note="Pfam match to entry PF00425 chorismate_bind,
FT                   chorismate binding enzyme, score 529.40, E-value 2.5e-155"
FT                   /gene="SCO3214"
FT                   /gene_synonym="SCE8.07c"
FT                   /gene_synonym="trpE2"
FT   gene            complement(5380..6396)
FT                   /gene="SCO3215"
FT                   /gene_synonym="SCE8.08c"
FT   CDS             complement(5380..6396)
FT                   /product="hypothetical protein"
FT                   /codon_start=1
FT                   /gene_synonym="SCE8.08c"
FT                   /transl_table=11
FT                   /note="SCE8.08c, unknown, len: 338 aa"
FT                   /note="smCOG: SMCOG1089:methyltransferase (Score: 57.7;
FT                   E-value: 2.1e-17);"
FT                   /db_xref="GI:4490624"
FT                   /db_xref="GOA:Q9Z4W6"
FT                   /db_xref="InterPro:IPR013216"
FT                   /db_xref="UniProtKB/TrEMBL:Q9Z4W6"
FT                   /translation="MTGDDVQGQLAELRRSHPELHALADPRRIAAWEAARGSAPGRHDD
FT                   FGADGEGSRGVEYVQAQALNRRARETGIRKLLGFAETARRTAAGDRPVLVDLLGGDGLV
FT                   RKVCEELGIGDFNILTCDASPHMVTTAWAAGVPALLQRAEQPLLRDHSVDAVLLAYGSH
FT                   HVPSSDRQTVATEARRMLRPGGTFVLHDFLVGSPVDVWFEEVTDVYSATGHKFLHFTRD
FT                   EIEGYLEKAGYDHREVVEIDDPYTAVAATPEEAELEIGRYLLNMYGLVKVFEGRTEQEA
FT                   YRWVAETAKAVFRYPDAEGGLASSELRQEGTGGWRVTIPRRAVVGVGRVSATAGKAA"
FT                   /gene="SCO3215"
FT                   /protein_id="CAB38586.1"
FT   gene            6689..9079
FT                   /gene="SCO3216"
FT                   /gene_synonym="SCE8.09"
FT   CDS             6689..9079
FT                   /product="putative integral membrane ATPase"
FT                   /codon_start=1
FT                   /gene_synonym="SCE8.09"
FT                   /transl_table=11
FT                   /note="SCE8.09, probable integral membrane ATPase, len: 796
FT                   aa; member of a large family including SW:Y1B2_MYCTU
FT                   putative cation-transporting ATPase from Mycobacterium
FT                   tuberculosis (797 aa) fasta scores; opt: 2741, z-score:
FT                   2896.9, E(): 0, (56.8% identity in 791 aa overlap).
FT                   Contains two Pfam matches to entry PF00122 E1-E2_ATPase,
FT                   E1-E2 ATPases, score 109.40, E-value 9.7e-30 and score
FT                   155.80, E-value 7.3e-43, and Prosite match to PS00154 E1-E2
FT                   ATPases phosphorylation site."
FT                   /note="smCOG:
FT                   SMCOG1037:heavy_metal_translocating_P-type_ATPase (Score:
FT                   464.6; E-value: 1e-140);"
FT                   /db_xref="GI:4490625"
FT                   /db_xref="GOA:Q9Z4W5"
FT                   /db_xref="InterPro:IPR000695"
FT                   /db_xref="InterPro:IPR001757"
FT                   /db_xref="InterPro:IPR005834"
FT                   /db_xref="InterPro:IPR008250"
FT                   /db_xref="InterPro:IPR018303"
FT                   /db_xref="UniProtKB/TrEMBL:Q9Z4W5"
FT                   /translation="MKNQLDEPGGAVRVGGGGGLSAAEVAERVAAGQVNDVPARSSRTI
FT                   GEIVRSNLFTRINAIIGVLFVIVMIVGPVQDGLFGGVILANTAIGIIQEVRAKRTLDQL
FT                   AIVGESRPRVWRDGQRLELSASEIVIDDSIDLGQGDKIVVDGTVTSGDSLEVDESLLTG
FT                   EADPVVKQPGDPVMSGSFVVAGSGTFTATRVGKEAYASQLADEARRFSLVNSELRNGID
FT                   RILKFVTYAIVPAGIALIITQFVVNDDNFSEAIRRMVGGLVPMVPEGLVLLTSLAFAVG
FT                   VVRLGKKQCLVQELPAIEGLARVDTVCLDKTGTLTEASMDVDEVLPLLPELPVDAVLGA
FT                   LGAADERPNASLQAIIESYPAPEGWRRTATAPFSSARRWSGASFAEPSGTESAWLLGAP
FT                   DTMLPAGHSVLTAADSYGARGLRVLLLARSDRPLDTLMDDPAAVPAAVTAAALVVIKQR
FT                   VRPEARATLDYFADQGVTAKVISGDNAVSVGAVASSLSLPGAERPVDARFLPDEPAELA
FT                   DAVEENTVFGRVGPQQKRDMVGALQSRGHTVAMTGDGVNDVLALKDADIGVGMGSGSPA
FT                   TRAVAQIVLLNNNFSALPSVVAEGRRVIGNIERVANLFLTKTVYSVLMALVVVIAQVPY
FT                   PFLPRHITLVGSLTIGIPAFFLALAPNKERARSNFVGRVLRFAIPAGALAAAATSVAYL
FT                   IARSVYDDNLDAETSAATLALFLTALWALAVIARPYTWWRVLLVLTMAVGFAVVLVVPY
FT                   LQEFFQLKLVGVTAPWAAVACAAVAGLVLELVWARMRRRLDAD"
FT                   /gene="SCO3216"
FT                   /protein_id="CAB38587.1"
FT   misc_feature    6917..7672
FT                   /note="Pfam match to entry PF00122 E1-E2_ATPase, E1-E2
FT                   ATPases, score 155.80, E-value 7.3e-43"
FT                   /gene="SCO3216"
FT                   /gene_synonym="SCE8.09"
FT   misc_feature    7616..7636
FT                   /note="PS00154 E1-E2 ATPases phosphorylation site."
FT                   /gene="SCO3216"
FT                   /gene_synonym="SCE8.09"
FT   misc_feature    8063..8671
FT                   /note="Pfam match to entry PF00122 E1-E2_ATPase, E1-E2
FT                   ATPases, score 109.40, E-value 9.7e-30"
FT                   /gene="SCO3216"
FT                   /gene_synonym="SCE8.09"
FT   gene            9824..11740
FT                   /gene="SCO3217"
FT                   /gene_synonym="cdaR"
FT                   /gene_synonym="SCE8.10"
FT   CDS             9824..11740
FT                   /product="putative transcriptional regulator"
FT                   /codon_start=1
FT                   /gene_synonym="cdaR"
FT                   /gene_synonym="SCE8.10"
FT                   /transl_table=11
FT                   /note="SCE8.10, cdaR, transcriptional activator protein,
FT                   len: 638 aa; Previously sequenced and therefore identical
FT                   to CdaR (EM:AF124138) transcriptional activator protein for
FT                   the CDA biosynthesis cluster in Streptomyces coelicolor.
FT                   Also similar to many including SW:AFSR_STRCO AfsR, a global
FT                   regulatory protein for secondary metabolite formation in
FT                   Streptomyces coelicolor A3(2) (993 aa) fasta scores; opt:
FT                   972, z-score: 1087.1, E(): 0, (36.6% identity in 610 aa
FT                   overlap) and SW:REDD_STRCO regulator of undecylprodigiosin
FT                   production in Streptomyces coelicolor A3(2) (350 aa) fasta
FT                   scores; opt: 382, z-score: 432.2, E(): 9.1e-17, (32.6%
FT                   identity in 258 aa overlap). Contains match to PS00017
FT                   ATP/GTP-binding site motif A (P-loop)."
FT                   /note="smCOG:
FT                   SMCOG1041:transcriptional_regulator,_SARP_family (Score:
FT                   596.4; E-value: 1.8e-180);"
FT                   /db_xref="GI:4490626"
FT                   /db_xref="GOA:Q9Z389"
FT                   /db_xref="InterPro:IPR000767"
FT                   /db_xref="InterPro:IPR001867"
FT                   /db_xref="InterPro:IPR002182"
FT                   /db_xref="InterPro:IPR003593"
FT                   /db_xref="InterPro:IPR005158"
FT                   /db_xref="InterPro:IPR011990"
FT                   /db_xref="InterPro:IPR011991"
FT                   /db_xref="InterPro:IPR016032"
FT                   /db_xref="UniProtKB/TrEMBL:Q9Z389"
FT                   /translation="MDLRLIEPIYQRIGNAEVSQKETPTAGLEFGVLGPLEVHMNGRGL
FT                   TVGGPRQRAVLSALLLSANQVVSFDSLIEEVWNGRPPSTARTQVAICIATLRKIFRTAG
FT                   WEQETIITATPGYMLSLAGHSLDSLRFEQLVSRATELTADERPAPAAEALRQALALWRG
FT                   PALGGVHAPFAETEAARLDEQRMLAVEQHMALRLQLGEHQSVLGELQALVGACPLRDRL
FT                   RYYLMLAQYRSGRRAEALTTFRDGMRYSIEEIGLELGTDLQSLHDSILRDEFPQLGVLG
FT                   IAAARKDRQQTVPSQLPESDAYFIGRSREQWLMDDVLLDGSAQNPPAIAYLTGSPGIGK
FT                   TSLAVNWAHRAAHRFPDGQLFADLREGGPLEVLHQFLRQLGDEGPLPAEPAEAAERYRG
FT                   LLEGRRVLIVLDHASSYAQVRHLLPTSGGCCVLITGRANLDELMQKYRTFRLRVAPLSD
FT                   DEARETLAGVLRDSRAQDVPEATSRLAALCGHSPLALRAAAARLLTKTHWRVLDLVCRL
FT                   ERSGDRLTALSIGEDSLRARLDRSMRELDPRVAFAYRELSRLGDADFDAEQAAQVLGTD
FT                   LLEAEDLIETLVDAQLLEAVGRSRWGGMRFKWQELVRLHASHCLTAAGSLETPAPVAVA
FT                   LTD"
FT                   /gene="SCO3217"
FT                   /protein_id="CAB38588.1"
FT   misc_feature    10823..10846
FT                   /note="PS00017 ATP/GTP-binding site motif A (P-loop)."
FT                   /gene="SCO3217"
FT                   /gene_synonym="cdaR"
FT                   /gene_synonym="SCE8.10"
FT   gene            complement(11802..12017)
FT                   /gene="SCO3218"
FT                   /gene_synonym="SCE8.11c"
FT   CDS             complement(11802..12017)
FT                   /product="putative small conserved hypothetical protein"
FT                   /codon_start=1
FT                   /gene_synonym="SCE8.11c"
FT                   /transl_table=11
FT                   /note="SCE8.11c, small conserved hypothetical protein, len:
FT                   71aa; similar to others located within antibiotic synthesis
FT                   clusters egs. TR:O52824 (EMBL:AJ223999) hypothetical
FT                   protein located within the vancomycin biosynthesis cluster
FT                   in Amycolatopsis orientalis (56 aa) fasta scores; opt: 281,
FT                   z-score: 402.6, E(): 4e-15, (67.3% identity in 52 aa
FT                   overlap) and SW:YBDZ_ECOLI hypothetical protein located
FT                   within the enterobactin region of Escherichia coli (72 aa)
FT                   fasta scores; opt: 186, z-score: 272.4, E(): 7.3e-08,
FT                   (32.8% identity in 64 aa overlap)."
FT                   /note="smCOG: SMCOG1009:mbtH-like_protein (Score: 112.4;
FT                   E-value: 1e-34);"
FT                   /db_xref="GI:4490627"
FT                   /db_xref="InterPro:IPR005153"
FT                   /db_xref="InterPro:IPR015166"
FT                   /db_xref="UniProtKB/TrEMBL:Q9Z388"
FT                   /translation="MTNPFEDADGRYLVLVNDEGQHSLWPSFVDVPAGWTVALGESDRE
FT                   ACLEYVEKNWTDMRPRSLVEAMSTGN"
FT                   /gene="SCO3218"
FT                   /protein_id="CAB38589.1"
FT   gene            complement(12140..13315)
FT                   /gene="SCO3219"
FT                   /gene_synonym="SCE8.12c"
FT   CDS             complement(12140..13315)
FT                   /product="putative lipase (putative secreted protein)"
FT                   /codon_start=1
FT                   /gene_synonym="SCE8.12c"
FT                   /transl_table=11
FT                   /note="SCE8.12c, possible lipase (putative secreted
FT                   protein), len: 391 aa; weak similarity to many eukaryotic
FT                   lipases e.g. SW:PAFA_CAVPO platelet-activating
FT                   factor-acetylhydrolase from guinea pig (Cavia porcellus)
FT                   (436 aa) fasta scores; opt: 153, z-score: 161.7, E(): 0.11,
FT                   (22.9% identity in 319 aa overlap). Contains PS00120
FT                   Lipases, serine active site. Contains possible N-terminal
FT                   region signal peptide sequence"
FT                   /db_xref="GI:4490628"
FT                   /db_xref="GOA:Q9Z360"
FT                   /db_xref="InterPro:IPR005065"
FT                   /db_xref="UniProtKB/TrEMBL:Q9Z360"
FT                   /translation="MPNVREAGRPARRCATLVAALLLALVPFGAGAPGTAAARAAPAAD
FT                   AAWTASAVPAPTGALPVGVRTAHLRDTSRRDPWNPDRYRELALSLWYPALPSRAPRASY
FT                   VTARESALILRFHRVEGVPADLLARFRVHARTAPPPLPAPARGLPLVLLSPGFALPRSS
FT                   LTGLAEELASRGYAVAAVDHAYEAPAISHPDGRVTGCLACRRHPEGARVAATRAADLRF
FT                   VRERLLRSPGAVGLPRLDPSRVAVVGHSMGGAAAFEALRTDAGFAAAANLDGTVHTGGR
FT                   SPVDRPFLLLGAGEHGRPGADPTWQRAWRDLSGPRRWLSVRGAGHLSFTDYARLLERTG
FT                   TAGEEVTLGAADAGRVTRELVVAFLDERLRRYGPRLDTAARQDPEVVTHGR"
FT                   /gene="SCO3219"
FT                   /protein_id="CAB38590.1"
FT   misc_feature    complement(12557..12586)
FT                   /note="PS00120 Lipases, serine active site."
FT                   /gene="SCO3219"
FT                   /gene_synonym="SCE8.12c"
FT   gene            complement(13523..13951)
FT                   /gene="SCO3220"
FT                   /gene_synonym="SCE8.13c"
FT   CDS             complement(13523..13951)
FT                   /product="putative secreted protein"
FT                   /codon_start=1
FT                   /gene_synonym="SCE8.13c"
FT                   /transl_table=11
FT                   /note="SCE8.13c, putative secreted protein, len: 142 aa;
FT                   contains alanine-rich N-terminal region and possible
FT                   N-terminal region signal peptide sequence"
FT                   /db_xref="GI:4490629"
FT                   /db_xref="UniProtKB/TrEMBL:Q9Z4W4"
FT                   /translation="MRGILRATALTAAIGAVALLPTTAASAAPAGPAASGCVTDSETED
FT                   FGRGEITVCVEDGEVRVTGHVEDLKPGGPFNGGDSGCVGWWIDWETASGPDSSTSTLAC
FT                   PHFTDKPYVEFDYDPTESEYGPKDVTGVADTHLTMVFM"
FT                   /gene="SCO3220"
FT                   /protein_id="CAB38591.1"
FT   gene            complement(14044..14898)
FT                   /gene="SCO3221"
FT                   /gene_synonym="SCE8.14c"
FT   CDS             complement(14044..14898)
FT                   /product="putative oxidoreductase"
FT                   /codon_start=1
FT                   /gene_synonym="SCE8.14c"
FT                   /transl_table=11
FT                   /note="SCE8.14c, probable oxidoreductase, len: 284 aa;
FT                   similar to many e.g. TR:O52817 (EMBL:AJ223999) protein
FT                   similar to prephenate dehydrogenase from the vancomycin
FT                   biosynthesis of Amycolatopsis orientalis (367 aa) fasta
FT                   scores; opt: 757, z-score: 865.8, E(): 0, (49.8% identity
FT                   in 283 aa overlap) and SW:TYRA_BACSU prephenate
FT                   dehydrogenase from Bacillus subtilis (372 aa) fasta scores;
FT                   opt: 251, z-score: 291.1, E(): 6.6e-09, (28.3% identity in
FT                   251 aa overlap)."
FT                   /db_xref="GI:4490630"
FT                   /db_xref="GOA:Q9Z4W3"
FT                   /db_xref="InterPro:IPR003099"
FT                   /db_xref="InterPro:IPR008927"
FT                   /db_xref="InterPro:IPR016040"
FT                   /db_xref="UniProtKB/TrEMBL:Q9Z4W3"
FT                   /translation="MRSVVIVGAGVIGRSVGLALRRHGVTTYLTDADPEAALAGERCGA
FT                   GFAAPPPRQADIAVLAVPPDQVAPVLAEHQKLGTARCYTDVSGVKVRLHREVRAHGCDL
FT                   TSLVSGAPVVGGSGPVQARADLFDGRPWALTPTEATGNLALNCALELVALCGAVSVLLD
FT                   PETHDRAVALVSHAPHLVASLVAARLLGGDESAVRLAGQDLRDVTRTADANPERWARIL
FT                   TANAGPVADQLDDWAAEAQAMARELRDAARSGDTDGPVRLRETLRFGVAGRARIREPHT
FT                   PSS"
FT                   /gene="SCO3221"
FT                   /protein_id="CAB38592.1"
FT   gene            complement(14996..15451)
FT                   /gene="SCO3222"
FT                   /gene_synonym="SCE8.15c"
FT   CDS             complement(14996..15451)
FT                   /product="putative secreted protein"
FT                   /codon_start=1
FT                   /gene_synonym="SCE8.15c"
FT                   /transl_table=11
FT                   /note="SCE8.15c, possible small secreted protein, len: 169
FT                   aa; similar to TR:Q9K3L2 (EMBL:AL360055) Streptomyces
FT                   coelicolor putative secreted protein SCG20A.28c, 150 aa;
FT                   fasta scores: opt: 727 Z-score: 859.9 E(): 2.9e-40; 72.109%
FT                   identity in 147 aa overlap. Contains possible N-terminal
FT                   signal sequence"
FT                   /db_xref="GI:4490631"
FT                   /db_xref="InterPro:IPR015141"
FT                   /db_xref="InterPro:IPR016090"
FT                   /db_xref="PDB:1FAZ"
FT                   /db_xref="UniProtKB/TrEMBL:Q9Z4W2"
FT                   /translation="MRTTTRTRTTLAAVGAALALGVAAAPAQAAPADKPQVLASFTQTS
FT                   ASSQNAWLAANRNQSAWAAYEFDWSTDLCTQAPDNPFGFPFNTACARHDFGYRNYKAAG
FT                   SFDANKSRIDSAFYEDMKRVCTGYTGEKNTACNSTAWTYYQAVKIFG"
FT                   /gene="SCO3222"
FT                   /protein_id="CAB38593.1"
FT   gene            complement(15606..16400)
FT                   /gene="SCO3223"
FT                   /gene_synonym="SCE8.16c"
FT   CDS             complement(15606..16400)
FT                   /product="putative ABC transporter integral membrane
FT                   protein"
FT                   /codon_start=1
FT                   /gene_synonym="SCE8.16c"
FT                   /transl_table=11
FT                   /note="SCE8.16c, probable ABC transporter integral membrane
FT                   protein, len: 266aa; located directly downstream of a
FT                   probable ABC transporter ATP-binding protein (6bp gap).
FT                   Similar to many particularly TR:O86630 (EMBL:AL031155) an
FT                   integral membrane protein located directly downstream of a
FT                   probable ABC transporter ATP-binding protein (2bp gap) from
FT                   Streptomyces coelicolor (279 aa) fasta scores; opt: 460,
FT                   z-score: 539.7, E(): 9.4e-23, (37.0% identity in 273 aa
FT                   overlap). Contains several probable membrane spanning
FT                   hydrophobic regions."
FT                   /db_xref="GI:4490632"
FT                   /db_xref="UniProtKB/TrEMBL:Q9Z4W1"
FT                   /translation="MTTTTVPKLVGPVKGGGFKGAVAFEWTKFWSVRATWWNLAVGLLL
FT                   TVAFAAMVGASADASAKKGVDVTMPAPHHASQAFLISQLTIVVLATLALTSEYSSGSIR
FT                   TTLQSVPARGRMLRSKTLVVAAVVVASGFVFSLLGTLVAAPLMGDYGDYSSGQLFGTAL
FT                   GAGVYLALLAVMAIGLGTVLRSAAGTITTLIMVLLALPQLMGVVGAKWLETASDYMPSV
FT                   AGTVLLTQDSDPYGAGTALLVLLLWALAAYAAGTAVLRRRDA"
FT                   /gene="SCO3223"
FT                   /protein_id="CAB38594.1"
FT   gene            complement(16407..17360)
FT                   /gene="SCO3224"
FT                   /gene_synonym="SCE8.17c"
FT   CDS             complement(16407..17360)
FT                   /product="putative ABC transporter ATP-binding protein"
FT                   /codon_start=1
FT                   /gene_synonym="SCE8.17c"
FT                   /transl_table=11
FT                   /note="SCE8.17c, probable ABC transporter ATP-binding
FT                   protein, len: 317aa; similar to many egs. TR:O86629
FT                   (EMBL:AL031155) ABC transporter ATP-binding protein from
FT                   Streptomyces coelicolor (312 aa) fasta scores; opt: 1080,
FT                   z-score: 1174.5, E(): 0, (57.4% identity in 303 aa overlap)
FT                   and SW:BCRA_BACLI bacitracin-resistance ABC transporter
FT                   from Bacillus licheniformis (306 aa) fasta scores; opt:
FT                   567, z-score: 621.0, E(): 2.8e-27, (42.4% identity in 217
FT                   aa overlap). N-terminal region previously sequenced
FT                   therefore identical to TR:P72389 (EMBL:U51332) partial,
FT                   designated D7 (103 aa) fasta scores; opt: 666, z-score:
FT                   734.8, E(): 0, (99.0% identity in 103 aa overlap). Contains
FT                   Pfam match to entry PF00005 ABC_tran, ABC transporter,
FT                   score 151.20, E-value 1.9e-41 and PS00017 ATP/GTP-binding
FT                   site motif A (P-loop)."
FT                   /note="smCOG: SMCOG1000:ABC_transporter_ATP-binding_protein
FT                   (Score: 167.7; E-value: 5.8e-51);"
FT                   /db_xref="GI:4490633"
FT                   /db_xref="GOA:Q9S6T6"
FT                   /db_xref="InterPro:IPR003439"
FT                   /db_xref="InterPro:IPR003593"
FT                   /db_xref="UniProtKB/TrEMBL:Q9S6T6"
FT                   /translation="MITLDRLTKRYGDKTAVSDLSFEINPGKVTGFLGPNGAGKSTTMR
FT                   MIVGLDAPTSGRALVGGKRYEELRHPLREVGALLDARAGHPGRSARHHLLGLARSNGIP
FT                   ASRVGEVLQTVGLSEVANKRIGSFSLGMGQRLGIAAALLGDPKVLLFDEPVNGLDPDGV
FT                   RWVRELMRSLAAEGRTIFVSSHLMSEMQETADHLLVIGRGKIIADAPIEEVIAGSSLTA
FT                   VRVRTPQPDVLRRELLEFGLRVEPNADSAPDELLVVGGTLEEIGDLAFHHRVPIHELSM
FT                   RKASLEQAYMELTAASVEYGSPALSQVTEVPDHQKA"
FT                   /gene="SCO3224"
FT                   /protein_id="CAB38595.1"
FT   misc_feature    complement(16752..17282)
FT                   /note="Pfam match to entry PF00005 ABC_tran, ABC
FT                   transporter, score 151.20, E-value 1.9e-41."
FT                   /gene="SCO3224"
FT                   /gene_synonym="SCE8.17c"
FT   misc_feature    complement(17238..17261)
FT                   /note="PS00017 ATP/GTP-binding site motif A (P-loop)."
FT                   /gene="SCO3224"
FT                   /gene_synonym="SCE8.17c"
FT   gene            17497..19212
FT                   /gene="SCO3225"
FT                   /gene_synonym="absA1"
FT                   /gene_synonym="SCE8.18"
FT   CDS             17497..19212
FT                   /product="two component sensor kinase"
FT                   /codon_start=1
FT                   /gene_synonym="absA1"
FT                   /gene_synonym="SCE8.18"
FT                   /transl_table=11
FT                   /note="SCE8.18, absA1, two component sensor kinase, len:
FT                   571aa; sequenced previously therefore identical to
FT                   TR:Q53893 (EMBL:U51332) AbsA1, predicted sensor histidine
FT                   kinase which acts as part of a two component signal
FT                   transduction system in the global regulation of antibiotic
FT                   synthesis in Streptomyces coelicolor (571 aa) fasta scores;
FT                   opt: 3782, z-score: 3585.7, E(): 0, (100.0% identity in 571
FT                   aa overlap)."
FT                   /note="smCOG: SMCOG1048:sensor_histidine_kinase (Score:
FT                   160.0; E-value: 9.46e-48);"
FT                   /db_xref="GI:4490634"
FT                   /db_xref="GOA:Q53893"
FT                   /db_xref="InterPro:IPR003594"
FT                   /db_xref="InterPro:IPR011712"
FT                   /db_xref="UniProtKB/TrEMBL:Q53893"
FT                   /translation="MHRWQAVRRRIESLVRVLGSERPFTRRADLVLLLVLLVPSAFATG
FT                   TLETAPVAWLTACLLIAAAVVVQRTAPLLSLLLAALLTLFYPWFGANLWPSMATVVLSC
FT                   LAGRRLTRLWPAHLVFLCVAAAGLLLVATVGQGKDWLSLLMTEFVACVLPWWAGNWWSQ
FT                   RTALTHAGWEHAEQLEWRQRYIADQARMKERARIAQDIHDSLGHELSVMALLAGGLELA
FT                   PGLSDPHRESVGQLRERCTMATERLHEVIGLLREDPNPSLTPADESVAQLVRRFQRSGT
FT                   PVRFQEDGARDRPGTPLLSDLAAYRVVQEALTNAAKHAPGAPIDVRVTHTADETVVSVV
FT                   NERPERGGSVPAAGSGSGLIGLDERVRLAGGTLRTGPRAGGFEVYARLPRGASSPSRST
FT                   EPPGPADGDGTAGGSGDGTAPGAATAGNEGRAAAAAADLPAPSGPWRSASRAALLRTRA
FT                   RIRRDARRAALIPAVLGAAIVAFLGGLYVFTSATTSLAPEDYARIRVGETRADLAPALP
FT                   ERRIKKPPPVTSEPSVPAGTTCEYYRASSGLLDFGGAMYRLCFKDDVLMAKDTL"
FT                   /gene="SCO3225"
FT                   /protein_id="CAB38596.1"
FT   gene            19231..19899
FT                   /gene="SCO3226"
FT                   /gene_synonym="absA2"
FT                   /gene_synonym="SCE8.19"
FT   CDS             19231..19899
FT                   /product="two component system response regulator"
FT                   /codon_start=1
FT                   /gene_synonym="absA2"
FT                   /gene_synonym="SCE8.19"
FT                   /transl_table=11
FT                   /note="SCE8.19, absA2, two component system response
FT                   regulator, len: 222aa; sequenced previously therefore
FT                   identical to TR:Q53894 (EMBL:U51332) AbsA2, predicted
FT                   response regulator which acts as part of a two component
FT                   signal transduction system in the global regulation of
FT                   antibiotic synthesis in Streptomyces coelicolor (222 aa)
FT                   fasta scores; opt: 1376, z-score: 1584.1, E(): 0, (100.0%
FT                   identity in 222 aa overlap). Contains Pfam matches to
FT                   entries PF00072 response_reg, Response regulator receiver
FT                   domain, score 138.20, E-value 1.5e-37 and PF00196 GerE,
FT                   Bacterial regulatory proteins, luxR family, score 70.90,
FT                   E-value 2.7e-17. Contains a probable helix-turn-helix motif
FT                   at 171-192aa (Score 1177 (+3.20 SD))."
FT                   /note="smCOG:
FT                   SMCOG1016:LuxR_family_DNA-binding_response_regulator
FT                   (Score: 209.9; E-value: 4.3e-64);"
FT                   /db_xref="GI:4490635"
FT                   /db_xref="GOA:Q53894"
FT                   /db_xref="HSSP:1A04"
FT                   /db_xref="InterPro:IPR000792"
FT                   /db_xref="InterPro:IPR001789"
FT                   /db_xref="InterPro:IPR011006"
FT                   /db_xref="InterPro:IPR011991"
FT                   /db_xref="InterPro:IPR016032"
FT                   /db_xref="UniProtKB/TrEMBL:Q53894"
FT                   /translation="MIRVLLADDETIIRAGVRSILTTEPGIEVVAEASDGREAVELARK
FT                   HRPDVALLDIRMPEMDGLTAAGEMRTTNPDTAVVVLTTFGEDRYIERALDQGVAGFLLK
FT                   ASDPRDLISGVRAVASGGSCLSPLVARRLMTELRRAPSPRSEVSGERTTLLTKREQEVL
FT                   GMLGAGLSNAEIAQRLHLVEGTIKTYVSAIFTQLEVRNRVQAAIIAYEAGLVKDADLNR
FT                   "
FT                   /gene="SCO3226"
FT                   /protein_id="CAB38597.1"
FT   misc_feature    19234..19575
FT                   /note="Pfam match to entry PF00072 response_reg, Response
FT                   regulator receiver domain, score 138.20, E-value 1.5e-37."
FT                   /gene="SCO3226"
FT                   /gene_synonym="absA2"
FT                   /gene_synonym="SCE8.19"
FT   misc_feature    19684..19881
FT                   /note="Pfam match to entry PF00196 GerE, Bacterial
FT                   regulatory proteins, luxR family, score 70.90, E-value
FT                   2.7e-17."
FT                   /gene="SCO3226"
FT                   /gene_synonym="absA2"
FT                   /gene_synonym="SCE8.19"
FT   gene            complement(19889..21223)
FT                   /gene="SCO3227"
FT                   /gene_synonym="SCE63.06"
FT                   /gene_synonym="SCE8.20c"
FT   CDS             complement(19889..21223)
FT                   /product="putative aminotransferase"
FT                   /codon_start=1
FT                   /gene_synonym="SCE63.06"
FT                   /gene_synonym="SCE8.20c"
FT                   /transl_table=11
FT                   /note="SCE8.20c, partial CDS, possible aminotransferase,
FT                   len: 431 aa; similar to many of undefined function e.g.
FT                   TR:O52815 (EMBL:AJ223998) a protein similar to
FT                   aminotransferase, from a cluster of genes involved in the
FT                   biosynthesis of a vancomycin group antibiotic in
FT                   Amycolatopsis orientalis (Actinomycete) (438 aa) fasta
FT                   scores; opt: 953, z-score: 1093.1, E(): 0, (48.4% identity
FT                   in 426 aa overlap). Also similar to TR:Q64602 (EMBL:Z50144)
FT                   kynurenine/alpha-aminoadipate aminotransferase from rat
FT                   (Rattus norvegicus) kidney (425 aa) fasta scores; opt: 293,
FT                   z-score: 338.4, E(): 1.5e-11, (25.8% identity in 419 aa
FT                   overlap).; SCE63.06, partial CDS, possible
FT                   aminotransferase, len: >45 aa; similar to the N-terminal
FT                   region of TR:O52815 (EMBL:AJ223998) a protein similar to
FT                   aminotransferase from a cluster of genes nvolved in the
FT                   biosynthesis of a vancomycin group antibiotic in
FT                   Amycolatopsis orientalis (Actinomycete) (438 aa) fasta
FT                   scores; opt: 87, z-score: 147.0, E(): 0.69, (45.2% identity
FT                   in 31 aa overlap). The remainder of this CDS lies on the
FT                   neighbouring Streptomyces coelicolor cosmid E8."
FT                   /note="smCOG: SMCOG1019:aminotransferase (Score: 318.7;
FT                   E-value: 8.9e-97);"
FT                   /db_xref="GI:24426511"
FT                   /db_xref="GOA:Q8CJX3"
FT                   /db_xref="InterPro:IPR004839"
FT                   /db_xref="InterPro:IPR015421"
FT                   /db_xref="InterPro:IPR015422"
FT                   /db_xref="InterPro:IPR015424"
FT                   /db_xref="UniProtKB/TrEMBL:Q8CJX3"
FT                   /sec_met="NRPS/PKS subtype: PKS/NRPS-like protein"
FT                   /sec_met="NRPS/PKS Domain: Aminotran_1_2 (86-431). E-value:
FT                   1.6e-31. Score: 100.9;"
FT                   /translation="MTTTTPARTDRDGVLARTALHPSLSAPLLDTMNFLNEVTLRYPQA
FT                   ISFAPGRPYEGDFDVARVPGYIETYLDHLRGRGHSEERVRTALYQYGETAGQIRDIVAR
FT                   MLEVDEDLTVDPASVVVTVGCQEAVLLTLRALFTGPEDVLLVDSPAYVGITGAAGLLDI
FT                   PVVPVPGTPDGPSPEGLERTVREIEASGRRARCLYVVPDCSNPTGVSLRREARTALLDA
FT                   AARLDLLLLEDNPYGVFSRVRRPTLKSLDTERRVVYLGSFAKTAFPGARVGFVVADQLV
FT                   AGADGRPPGLLAHELAKVKSMVTVNTPTLSQAAVAGLLLQNGGGLRAANEASARHYQST
FT                   MRCLRDTLAAELPPGAPESGGVRWNDPDGGFFLTLDVPFEADEAALDVSAEKYGVIWTP
FT                   MRHFHLDDAGDRQIRLSCSYLTTDRAAEGATRLARFVKDRAASNG"
FT                   /gene="SCO3227"
FT                   /protein_id="CAD55497.1"
FT   gene            complement(21220..22353)
FT                   /gene="SCO3228"
FT                   /gene_synonym="SCE63.05"
FT   CDS             complement(21220..22353)
FT                   /product="putative glycolate oxidase"
FT                   /codon_start=1
FT                   /gene_synonym="SCE63.05"
FT                   /transl_table=11
FT                   /note="SCE63.05, probable glycolate oxidase, len: 377 aa;
FT                   similar to many both prokaryotic and eukaryotic e.g.
FT                   TR:O52792 (EMBL:AJ223998) similar to glycolate oxidase from
FT                   a cluster of genes nvolved in the biosynthesis of a
FT                   vancomycin group antibiotic in Amycolatopsis orientalis
FT                   (Actinomycete) (357 aa) fasta scores; opt: 995, z-score:
FT                   998.4, E(): 0, (47.5% identity in 343 aa overlap) and
FT                   SW:GOX_SPIOL glycolate oxidase from Spinacia oleracea
FT                   (spinach) (369 aa) fasta scores; opt: 917, z-score: 920.7,
FT                   E(): 0, (41.9% identity in 360 aa overlap). Contains Pfam
FT                   match to entry PF01070 FMN_dh, FMN-dependent de
FT                   hydrogenase, score 412.60, E-value 3.6e-120 and PS00557
FT                   FMN-dependent alpha-hydroxy acid dehydrogenases active
FT                   site."
FT                   /db_xref="GI:4481936"
FT                   /db_xref="GOA:Q9Z4X8"
FT                   /db_xref="HSSP:1GOX"
FT                   /db_xref="InterPro:IPR000262"
FT                   /db_xref="InterPro:IPR008259"
FT                   /db_xref="InterPro:IPR012133"
FT                   /db_xref="InterPro:IPR013785"
FT                   /db_xref="UniProtKB/TrEMBL:Q9Z4X8"
FT                   /translation="MREPLTLDDFARLARGQLPAATWDFIAGGAGRERTLAANEAVFGA
FT                   VRLRPRALPGIEEPDTSVEVLGSRWPAPVGIAPVAYHGLAHPDGEPATAAAAGALGLPL
FT                   VVSTFAGRSLEEVARAASAPLWLQLYCFRDHETTLGLARRARDSGYQALVLTVDTPFTG
FT                   RRLRDLRNGFAVPAHITPANLTGTAAAGSATPGAHSRLAFDRRLDWSFVARLGAASGLP
FT                   VLAKGVLTAPDAEAAVAAGVAGIVVSNHGGRQLDGAPATLEALPEVVSAVRGRCPVLLD
FT                   GGVRTGADVLAALALGARAVLVGRPALYALAVGGASGVRRMLTLLTEDFADTMVLTGHA
FT                   ATGTIGPDTLAPPHHAPPHHGPPTAPRPAPHRDRSHG"
FT                   /gene="SCO3228"
FT                   /protein_id="CAB38520.1"
FT   misc_feature    complement(21298..22314)
FT                   /note="Pfam match to entry PF01070 FMN_dh, FMN-dependent de
FT                   hydrogenase, score 412.60, E-value 3.6e-120"
FT                   /gene="SCO3228"
FT                   /gene_synonym="SCE63.05"
FT   misc_feature    complement(21592..21612)
FT                   /note="PS00557 FMN-dependent alpha-hydroxy acid dehydrogena
FT                   ses active site."
FT                   /gene="SCO3228"
FT                   /gene_synonym="SCE63.05"
FT   gene            complement(22503..23618)
FT                   /gene="SCO3229"
FT                   /gene_synonym="SCE63.04"
FT   CDS             complement(22503..23618)
FT                   /product="putative 4-hydroxyphenylpyruvic acid dioxygenase"
FT                   /codon_start=1
FT                   /gene_synonym="SCE63.04"
FT                   /transl_table=11
FT                   /note="SCE63.04, probable 4-hydroxyphenylpyruvic acid
FT                   dioxygenase, len: 371 aa; similar to many both prokaryotic
FT                   and eukaryotic e.g. TR:O52791 (EMBL:AJ223998) similar to
FT                   hydroxyphenyl pyruvate dioxygenase from a cluster of genes
FT                   involved in the biosynthesis of a vancomycin group
FT                   antibiotic in Amycolatopsis orientalis (Actinomycete) (357
FT                   aa) fasta scores; opt: 989, z-score: 1130.3, E(): 0, (48.7%
FT                   identity in 355 aa overlap) and SW:HPPD_MOUSE hpd,
FT                   4-hydroxyphenylpyruvic acid dioxygenase from Mus musculus
FT                   (mouse) (392 aa) fasta scores; opt: 610, z-score: 698.5,
FT                   E(): 1.3e-31, (31.6% identity in 361 aa overlap)."
FT                   /db_xref="GI:4481935"
FT                   /db_xref="GOA:Q9Z4X7"
FT                   /db_xref="InterPro:IPR004360"
FT                   /db_xref="InterPro:IPR005956"
FT                   /db_xref="UniProtKB/TrEMBL:Q9Z4X7"
FT                   /translation="MLPPFPFLHWRAAMPPSDIAYAELYVADDREASGFLVDSLGFVPL
FT                   AVAGPATGTHDRRSTVLRSGEVTLVVTQALAPDTPVARYVERHGDSIADLAFGCDDVRS
FT                   CFDRAVLAGAEALQAPTPSHRAGQDAWFATVSGFGDIRHTLVPAADGDGAGLLPPDRDW
FT                   ALLPAATGRTGPRPLLDHVAVCLESGTLRSTAEFYEAAFDMPYYSSEYIEVGEQAMDSI
FT                   VVRNAGGGITFTLIEPDDTRVPGQIDQFLSAHDGPGVQHLAFLVDDIVGSVRSLGDRGV
FT                   AFLRTPGAYYDLLTERVGAMADAIEDLRETNVLADRDEWGYLLQIFTRSPYPRGTLFYE
FT                   YIQRNGARGFGSSNIKALYEAVEREREVAGR"
FT                   /gene="SCO3229"
FT                   /protein_id="CAB38519.1"
FT   gene            23887..46278
FT                   /gene="SCO3230"
FT                   /gene_synonym="cdaPSI"
FT                   /gene_synonym="SCE63.03c"
FT   CDS             23887..46278
FT                   /product="CDA peptide synthetase I"
FT                   /codon_start=1
FT                   /gene_synonym="cdaPSI"
FT                   /gene_synonym="SCE63.03c"
FT                   /transl_table=11
FT                   /note="SCE63.03c, cdaPSI, CDA peptide synthetase I, len:
FT                   7463 aa; part of the calcium-dependent antibiotic (CDA)
FT                   biosynthetic cluster from Streptomyces coelicolor. CDA is a
FT                   peptide antibiotic which is synthesised non-ribosomally by
FT                   a putative multifunctional peptide synthetase enzyme. This
FT                   CDS encodes a subunit of this enzyme and is suspected to be
FT                   responsible for the incorperation of the first 6 amino
FT                   acids into the antibiotic structure. This ORF overlaps the
FT                   downstream (cdaPSII) ORF by one base indicating possible
FT                   translational coupling. Contains eight separate Pfam
FT                   matches to entry PF00668 DUF4, Domain of unknown function
FT                   (U), six separate Pfam matches to entry PF00501
FT                   AMP-binding, AMP-binding enzyme (A) and six separate Pfam
FT                   matches to entry PF00550 pp-binding, Phosphopantetheine
FT                   attachment site (P). These Pfam matches cover the full
FT                   length of the protein in the following order from N to
FT                   C-terminal U-A-P-U-A-P-U-A-P-U-U-A-P-U-A-P-U-A-P-U."
FT                   /note="smCOG:
FT                   SMCOG1127:condensation_domain-containing_protein (Score:
FT                   278.0; E-value: 1.824e-83);"
FT                   /db_xref="GI:4481934"
FT                   /db_xref="GOA:Q9Z4X6"
FT                   /db_xref="HSSP:1AMU"
FT                   /db_xref="InterPro:IPR000873"
FT                   /db_xref="InterPro:IPR001242"
FT                   /db_xref="InterPro:IPR006162"
FT                   /db_xref="InterPro:IPR006163"
FT                   /db_xref="InterPro:IPR009081"
FT                   /db_xref="InterPro:IPR010060"
FT                   /db_xref="InterPro:IPR010071"
FT                   /db_xref="InterPro:IPR020806"
FT                   /db_xref="InterPro:IPR020845"
FT                   /db_xref="UniProtKB/TrEMBL:Q9Z4X6"
FT                   /sec_met="Type: nrps"
FT                   /sec_met="Domains detected: Condensation (E-value: 7.4e-37,
FT                   bitscore: 118.3, seeds: 42); Condensation (E-value:
FT                   3.1e-67, bitscore: 218.1, seeds: 42); Condensation
FT                   (E-value: 1.2e-68, bitscore: 222.7, seeds: 42);
FT                   Condensation (E-value: 2.8e-44, bitscore: 142.7, seeds:
FT                   42); Condensation (E-value: 1.4e-63, bitscore: 206.1,
FT                   seeds: 42); Condensation (E-value: 7e-72, bitscore: 233.3,
FT                   seeds: 42); Condensation (E-value: 3.5e-71, bitscore:
FT                   231.0, seeds: 42); Condensation (E-value: 2.2e-34,
FT                   bitscore: 110.2, seeds: 42); AMP-binding (E-value:
FT                   9.6e-127, bitscore: 414.3, seeds: 400); AMP-binding
FT                   (E-value: 6.4e-126, bitscore: 411.5, seeds: 400);
FT                   AMP-binding (E-value: 1.7e-111, bitscore: 364.0, seeds:
FT                   400); AMP-binding (E-value: 4.6e-101, bitscore: 329.7,
FT                   seeds: 400); AMP-binding (E-value: 8.8e-103, bitscore:
FT                   335.3, seeds: 400); AMP-binding (E-value: 4.3e-116,
FT                   bitscore: 379.2, seeds: 400); PP-binding (E-value: 4.5e-16,
FT                   bitscore: 50.6, seeds: 164); PP-binding (E-value: 9e-18,
FT                   bitscore: 56.0, seeds: 164); PP-binding (E-value: 3.4e-13,
FT                   bitscore: 41.4, seeds: 164); PP-binding (E-value: 3.3e-17,
FT                   bitscore: 54.2, seeds: 164); PP-binding (E-value: 6.5e-17,
FT                   bitscore: 53.3, seeds: 164); PP-binding (E-value: 1.7e-13,
FT                   bitscore: 42.4, seeds: 164)"
FT                   /sec_met="Kind: biosynthetic"
FT                   /sec_met="NRPS/PKS subtype: NRPS"
FT                   /sec_met="NRPS/PKS Domain: Condensation_Starter (7-318).
FT                   E-value: 1.6e-103. Score: 337.4;"
FT                   /sec_met="NRPS/PKS Domain: AMP-binding (496-907). E-value:
FT                   8.9e-127. Score: 414.3;"
FT                   /sec_met="NRPS/PKS Domain: PCP (1092-1160). E-value:
FT                   5.3e-27. Score: 85.1;"
FT                   /sec_met="NRPS/PKS Domain: Condensation_LCL (1174-1480).
FT                   E-value: 4.1e-114. Score: 371.9;"
FT                   /sec_met="NRPS/PKS Domain: AMP-binding (1695-2121).
FT                   E-value: 5.9e-126. Score: 411.5;"
FT                   /sec_met="NRPS/PKS Domain: PCP (2202-2270). E-value:
FT                   1.5e-27. Score: 86.9;"
FT                   /sec_met="NRPS/PKS Domain: Condensation_LCL (2284-2585).
FT                   E-value: 1.5e-116. Score: 379.8;"
FT                   /sec_met="NRPS/PKS Domain: AMP-binding (2784-3184).
FT                   E-value: 1.6e-111. Score: 364.0;"
FT                   /sec_met="NRPS/PKS Domain: PCP (3267-3333). E-value:
FT                   5.6e-20. Score: 62.6;"
FT                   /sec_met="NRPS/PKS Domain: Epimerization (3349-3651).
FT                   E-value: 3.3e-133. Score: 436.3;"
FT                   /sec_met="NRPS/PKS Domain: Condensation_DCL (3824-4122).
FT                   E-value: 5.1e-114. Score: 371.7;"
FT                   /sec_met="NRPS/PKS Domain: AMP-binding (4303-4681).
FT                   E-value: 4.3e-101. Score: 329.7;"
FT                   /sec_met="NRPS/PKS Domain: PCP (4764-4833). E-value:
FT                   8.5e-29. Score: 90.9;"
FT                   /sec_met="NRPS/PKS Domain: Condensation_LCL (4846-5147).
FT                   E-value: 3.9e-118. Score: 385.1;"
FT                   /sec_met="NRPS/PKS Domain: AMP-binding (5343-5721).
FT                   E-value: 8.1e-103. Score: 335.3;"
FT                   /sec_met="NRPS/PKS Domain: PCP (5804-5871). E-value:
FT                   6.6e-27. Score: 84.8;"
FT                   /sec_met="NRPS/PKS Domain: Condensation_LCL (5886-6187).
FT                   E-value: 7.4e-119. Score: 387.4;"
FT                   /sec_met="NRPS/PKS Domain: AMP-binding (6381-6801).
FT                   E-value: 3.9e-116. Score: 379.2;"
FT                   /sec_met="NRPS/PKS Domain: PCP (6886-6953). E-value:
FT                   1.3e-23. Score: 74.3;"
FT                   /sec_met="NRPS/PKS Domain: Epimerization (6969-7279).
FT                   E-value: 3.3e-113. Score: 370.2;"
FT                   /translation="MSENSSVRHGLTSAQHEVWLAQQLDPRGAHYRTGSCLEIDGPLDH
FT                   AVLSRALRLTVAGTETLCSRFLTDEEGRPYRAYCPPAPEGSAAVEDPDGVPYTPVLLRH
FT                   IDLSGHEDPEGEAQRWMDRDRATPLPLDRPGLSSHALFTLGGGRHLYYLGVHHIVIDGT
FT                   SMALFYERLAEVYRALRDGRAVPAAAFGDTDRMVAGEEAYRASARYERDRAYWTGLFTD
FT                   RPEPVSLTGRGGGRALAPTVRSLGLPPERTEVLGRAAEATGAHWARVVIAGVAAFLHRT
FT                   TGARDVVVSVPVTGRYGANARITPGMVSNRLPLRLAVRPGESFARVVETVSEAMSGLLA
FT                   HSRFRGEDLDRELGGAGVSGPTVNVMPYIRPVDFGGPVGLMRSISSGPTTDLNIVLTGT
FT                   PESGLRVDFEGNPQVYGGQDLTVLQERFVRFLAELAADPAATVDEVALLTPDERERVLD
FT                   GWNDTAHEVPETTLPELFAARAARTPGHEALVYEGTSLTYAELDARAERLAGALTARGA
FT                   GPERFVAVAVERSAELVVALLAVLKSGAAYVPVDPGYPADRIAHILRDAGAMLVLTTRD
FT                   TAERLPGDGTPRLLLDEPAAAGTTAAGAPAPPGTLPRALPAPGHPAYVIYTSGSTGRPK
FT                   GVVISHRAIVNRLAWMQDTYGLEPSDRVLQKTPSGFDVSVWEFFWPLVQGATLVVARPG
FT                   GHTDPAYLAGTVRREGVTTLHFVPSMLDVFLREPAAAALGGATPVRRVFCSGEALPAEL
FT                   RARFRAVSDVPLHNLYGPTEAAVDVTYWPCAEDTGDGPVPIGRPVWNTRMYVLDAALRP
FT                   VPAGVPGELYIAGVQLARGYLGRPALSAERFTADPHGAPGSRMYRTGDLARWNHDGSLD
FT                   YLGRADHQVKLRGFRIELGEIEAALVRQPEIAQAAVVLREDRPGDQRLVAYTVPARDAD
FT                   TLTGPPAEAGTHPGPGAAPDTDPATGPAAGTDSGPGSGTGSGTGSGTGSGARPGPDGTA
FT                   THTVAGAGPAAAGETAAGADAGTGTGETGAGADAGTGTGAHAGPDGAVLAARLRELLPG
FT                   YMVPSAFVALPRLPVTPNGKLDRRALPAPAESGRAAGRAPRTPGEELLCALFAEVLGVA
FT                   EVRVDDGFFDLGGHSLLATRLISRIRATAGAEVPIRRVFEAPTVAELAPALTDGGRARA
FT                   AVTARPRPDRLPLSFAQRRLWFIHQYEGPSPLYNIPAALRLTGPVDGAALSAALGDVVA
FT                   RHESLRTVFAEDAHGPHQVILSAERAAPRLKTLDSDPERLAADLARTARHTFDLTRDVP
FT                   LRATLLRVAPEEHVLLLVLHHIAGDGWSLAPLARDLGTAYAARTAGTAPDWAPLPVQYA
FT                   DYTLWQRELLGADGNGAGTGDGGEGARQLAHWREALAGLPERLELPSDRPRPARRDNSG
FT                   ARLDVSVPAGLHRSLAALAAETRTSVFMVLQAALAGLLTRLGAGEDVPIGSTIAGRTDA
FT                   AVENLVGFFVNTLVLRTDTGGDPAFRELLSRVRERDLAAYAHQDVPFERLVEAVNPDRA
FT                   TSHHPLFQVMLTFDTTQQDALGELGRLPGITTSLLPVHTGLSRFDLVFAFDERRDAAGG
FT                   QAGLDLAVEFSTELFDAGTVRALTERLLLLLTQVAADPGVRLGDLDVLLPGEHHDLLVA
FT                   ANRPGTAPASPAPASPEPASPEPASPAPGTATLPELFERQAARHPDRTALTFEGTSLSY
FT                   AELNARANRLARLLTARGIGPDALVALALPRSAELVVALLAVVKSGAAYVPLDPGYPAD
FT                   RLAHALSDSAPAALLTDRATAGRLPAHEVPRIVLDAPAPADGGTTGGDPADAHPATDLA
FT                   QGERVRPLDPRDTAYVIYTSGSTGRPKGVAVPHGNVVRLFSATAPWFGFDEHDVWTLFH
FT                   SYAFDFSVWELWGPLLHGGRLVVVPHDVTRDPAAFLALLARERVTVLNQTPSAFHQLAA
FT                   ADRENPTELALRTVVFGGEALDLSRLADWYERHAEDAPALVNMYGITETTVHVSHFALD
FT                   RATAAASSASTIGVNIPDLRVYVLDDRLRPTAPGVTGEMYVAGAGLARGYLGRPALTAD
FT                   RFPADPYAALFGERGTRMYRTGDLARRRTDGGLDYLGRADQQVKIRGFRIEPGEIEAVL
FT                   AAHPAVDDVAVVAREDVQGDPRLVAYVVTGSGATARALHDHAAGHLPDHMLPSAFVTLD
FT                   VLPLTPNGKLDTKALPAPAHAGQVTGRAPRGPREEILCALFAEVLGVPRLTVDDSFFDL
FT                   GGHSLLATRLAGRIRGTLGVELSVRRLFETPTVAGLSAALDGAERSGTGPTAGERPERL
FT                   PLSYAQQRLWFLHQLEGPSPTYNITGALRLTGDLDPGALRAAFQDVVTRHESLRTVFSE
FT                   DGHGARQTVLDAAGVRFELPVADVSEDRLDARLEEAARHCFDLTTDIPVRAELFRLGAR
FT                   EHVLLLMVHHIAGDGWSLGPLIRDLAAAYTARAARRAPDWAPLPVQYADFALWQRAALG
FT                   DAADATSPAGRQLAHWKEALAGLPDRLELPADRPLPAVASHRGGRVPLTVPAPLHSGVA
FT                   ELARESRTSVFMVLQAALAALLTRMGAGEDVPLGTPVAGRGDDAVDQVVGFFVNTLVLR
FT                   TDTGGNPTFRALLDRVRDTDLTAYDHQDLPFEHLVDVLSPTRSLSHNPLFQVLLSLDTT
FT                   QQDALAALSATGLGVRLLNVTTGVAKLDLALEIAEHRDADGAPAGLVGAAEYSADLFDE
FT                   GTVTLLVERFLRLLDALVADPSRRIGDVDVLGPRERERVLTEWNDTPRRPVQGTFADHV
FT                   ARHAAERPGHLAVETAGAAAPGGALTYGELNERANRLARALLARGAGPERFVAVALPRS
FT                   ADLVLSALAAFKAGAAYLPVDPAHPAERITHLVSDAAPTLIVTTSALAASLPDTGTPVL
FT                   LLDTPETAATLAALPGHDVTDADRPVPLRPEHPAYMIYTSGTTGRPKGVVVTHTGLPGL
FT                   LDIFTRDCAAGPGSRILQHLSPSFDASFWELAMGLLTGATLVVAPPETTPGPELAELAT
FT                   RHAATHLSLTTSVLGLLPPDSLPDGLTLVVGAEAIPPELVERWSPGRTMLNSYGPTETT
FT                   VCSTMSGPLSGPAVPPIGSPVANSAVYVLDAALRPVPPGVPGELYAAGAHLARGYHDRR
FT                   ALTAERFVANPFGEPGSRLYRTGDLVRWRPDGQLEYLGRADTQVKIRGLRIEPTEIEAV
FT                   ITERPHLARAAVIVREDRPGDRRLVAYVVPEPGATVDTAELRAALRETLPDHMIPTAFV
FT                   VLDALPLTLNGKLDRKALPAPDYSARTSGRAARDPRERLLTALFGEILGVEPAGVDDGF
FT                   FDLGGDSILSIQLVARARAAGLVLSVRDVFEHQTPALLARSAAAAPAGDRTARDSDVPA
FT                   DGPAPRTPMMGWFAALGSDLAAFNQSLVLRVPAALDPDTLDTALRAVLDRHDALRMRVA
FT                   DDWTIEIPPPGSVTPADCLVRFDAVGLDEAAVRSAVTEQARTARDRLAPADGRMLQAVW
FT                   LDRGADRDGLLLLVANHLVVDGVTWRILVPDLAAAYAGETLAPVGTPWRHWALSLSDLA
FT                   GQPRTEEELDHWHSVLGDTPHTLRLDPARDTHATAGEITAELDADTTEALLTWVPGVCH
FT                   ATVNDVFLSTFALAVAGWRRGRGEDADAPVVLDLESHGRHEEAVPGVELSRTAGWFTSM
FT                   YPVRLAPPAGASGDGSALRALKAVKEQLRTVPGDGLGYGLLRHLNPRTRAALAALPLPE
FT                   FGFNYLGRIGQEGTDEAPWTIEGGDVAGIDGAMPLAHPVDVNAVARETADGTRLRARWT
FT                   YSRTALEPEDTQRLADTWFRLLRRLVEEARQPGAGGLTPSDIAHPALAQDEIEDLEHTV
FT                   PGLQDILPLAPLQEGFLFLNLYDENARDVYVGQLAFDLEGSFDGTRMRAAAGALLRRHA
FT                   NLRAGFRQTATGTWVQVVPAELEPDWRECDLTDRADEAERDAEAGRLAAGDRERRFDLT
FT                   SPPLMRFTAIRLSADRVRLVMTNHHILLDGWSMPLLWQELTELYVSGGDPVSLPPVRPY
FT                   RDHLAWLGARDRDAARDAWRRSLSGLDEATLLAPDAGPAEAAPLGIPFGLDRDATAALS
FT                   AWARGRGVTMNTVVQGAWALALAQATGRDDVVFGATVSGRPPELPGVESMIGLFINTLP
FT                   VRARLDQAEPLGDLFRRLQNEQARLLDHQWPGLADIQHWAGHGELFDTAMVFQNYPVSA
FT                   DTTSRQLDGLRVAGYDAVESTDFAVNLVAHTRDDALRLRLDYRADACAGDLVRSLADRM
FT                   LRVLEALVTDSDRPVAHLDTLDPAVRERVLVEWNGAPTQLPGTPLHELISEQARLTPDA
FT                   VAVVCDGTSLTYAELDGGANQLARHLLGEGLGAEDFVAIALAKSLDAVISMLAVLKTGA
FT                   AYLPIDPDYPAERITYMLDDARPALTLTEPVPVERYTGHSVTAVTDEERRSPWSARHAA
FT                   YMIYTSGSTGRPKGVVIEHHALATYLHRARNTYTAMTGVTVLHSPLAFDLTITALWTPL
FT                   TSGGTVHLTSLEESDTQPSLIKATPSHLPLLTTLPETASPSHTLILGGEALHTDHLVTW
FT                   RTQHPGVQIINAYGPTESTVNITDHHVGEDTPDGPVPIGRPFANTQVYVLDSALRPVAP
FT                   GVTGELYLAGEQLARGYLGRPALTAERFTANPHSSTPGARMYRTGDLAHWNHHGHLTYD
FT                   GRADHQIKLRGHRIEPGEIEATLTAQTGITQATVQLREDQPGDQRLVAYLVVNDSTEYD
FT                   EKTVRDALTSALPDYMVPSALVTLDALPLTPNGKLDRTALPAPAYSASTAGRAPRTPRE
FT                   EVLCTLFAEVLGVDLVTIDDNFFDLGGHSLLATRLVSRTRTALGVELSIRQLFETPTVA
FT                   GLAEALDASGTVRTALTARPRPERIPLSYAQQRLWFLHQLEGPSATYNTVLTLRLGGAL
FT                   DVDALRAAISDVVARHESLRTVFTEDERGAYQIVLPVEAASTPFTVVDVAEEEIGDRLD
FT                   EAVGHCFDLAQELPARTSLFRVSEREHVLLLLIHHIASDAWSRAPLAQDLTAAYAARVR
FT                   SEAPMWAPLTVQYADYALWQQEILGDDTDADSLAGRQLAYWKQQLAGLPEQLDLPTDRP
FT                   RPAVAGYSGDRVPFTVPTELHTRLTELARATNTSAFMVIQAAVAVLLTRLGAGEDIPIG
FT                   TPVAGRTDDAADDLIGLFINTLVLRTDTSGDPTFRRLLDRVRDTDLAAYAHQDLPFERL
FT                   VEALNPARTLSHHPLFQVLLTFNNTDHEGALKDISELPGLTVALREVQRTSSKFDLSFG
FT                   FAESFDTSRRPQGIEAALDFSTELLDRRSAQAIADRFLRVLEAVTTAPDRPIGAVELMD
FT                   PAERERVLVEWNGAPTQLPGTPLHELISEQARLTPDAVAVVCDGTTLTYAELDRRANQL
FT                   ARHLLGEGLGAEDFVAIALAKSLDAVISMLAVLKTGAAYLPIDPDYPAERITYMLDDAQ
FT                   PALTLTAPIPPASYDSRPTSEITDVERRSPWSARHAAYMIYTSGSTGRPKGVVIEHHAL
FT                   ATYLHRARNTYTAMTGVTVLHSPLAFDLTITALWTPLTAGGTVHLTSLEEAEVQPSLIK
FT                   ATPSHLPLLTTLPETASPSHTLILGGEALHTDHLATWRTQHPGAQIINAYGPTESTVNI
FT                   TDHHVSEDTPDGPVPIGRPFANTQVYVLDSALRPVAPGVTGELYLAGEQLARGYLGRPA
FT                   LTAERFTANPHSSTPGARMYRTGDLAHWNHDGHLTYDGRADHQIKLRGHRIEPGEIETT
FT                   LTAQTGITQTTVQLREDTPGDQRLVAYLVVNDSTEYDEPTLRDALASALPDYMRPSAYV
FT                   TLDALPLTPNGKLDRTALPAPAYSASTTGRTPRTPREEILCTLFAEVLGVDLVTIDDNF
FT                   FDLGGHSLLATRLVSRARTALGVELSVRQFFETPTIAGLSGAFDRAGRARAALTARPRP
FT                   ERIPLSYAQQRLWFLHQLEGPSATYNIPTTLRLTGTLDTDALQSALNDLLARHESLRTT
FT                   YTEDGEGPRQVIHAWEPGMLPLGVVDTGEGELDAMLSAGVHHAFDLTAGIPVRATLFRI
FT                   SEQEHVLLLLIHHIATDAWSRTPLGHDLAAAYSARCAGDVPAWEPLPVQYADYALWQRE
FT                   VLGDEGDADAPAGRQLAYWTRQLADLPEQLDLPTDRPRPAVASQDGDRVAFSLDADLYV
FT                   RLTELARATHSSTFMVVQAALAVLLTRLGAGEDIPIGTPVAGRTDDATENLVGFFVNTL
FT                   VLRNDTSGNPTFRELLEETRRTDLAAYAHQDLPFERLVEALNPARTLAHHPLFQVMLIL
FT                   STAETDPDASLALPGLRVGAERSRLGAAKVDLAFALAEVRDGEGRSTGLTGALDFRTDL
FT                   FDRSTARSLVERFVRTLEAVVADPGVRLSRVPVLTGSERRSLLDRGTGPLLEGLDATLP
FT                   ELFAEQALRTPGAPALVRGGTTVSYAELDLRTNRLARLLRQQGVRPGTPVVMLMERSPA
FT                   HVVATLAIAKAGGAYVPLHDTYPLDRMRHVVADTAATLILTDRAEAARAGQLGARVMVV
FT                   DEFGAAPSGSEADAAPGTGTGTGTGSRSGYVDDAPEVGLRPQDLAYVMYTSGSTGVPKG
FT                   VAVTHRGVVDLVRDHCWRPGVHERVLLHAPHAFDVSCYEMWVPLVSGGTVVVAPPGHLD
FT                   PAAITDLITAHDITAIHLTAGFFRVVAEEAPECFAGVREVLTGGDVVSPAAVARVLAHH
FT                   PRIVLRHLYGPTETTLCVTQHEVTAPYEARGSLPVGRATGNTRAYVLDRYLQPVPAGVP
FT                   GELFISGSGLARGYLDRPDLTCERFVADPYGGSGERMYRTGDLVRYNAAGELEYLARAD
FT                   DQVKIRGFRVELGEIEAVLATRPELAQAAVVVREDRPGDRRLVGYVVAAAGRDGEVDPD
FT                   ALRAFSRQALPDYMVPSAFVVLGTLPLTANGKLDRKALPAPDYGAASTGRAARTPAEEL
FT                   LCTLFAQVLGLSAVGVDDGFFDLGGDSILSIQLVSRARAAGLALAVRDVFEHQSTARLA
FT                   AALTDRDDAASVPEAEAVPPYGPAPLTPVMARIAELGLGGDDFNQSVVVSLPPAVDRDR
FT                   LVPALQRVLDHHDALRLRVLPDGSTEVRAPGSVPAADVLSVVTRAPGATGEARDALLVE
FT                   AACAARDRLAPAEGRMLQAVLVDGTDDTDGTGGTSGADGVLILVAHHLVVDSVTWSIVV
FT                   PDLAAAYRGEEPAPVGTSWRQWATSLARLATDPRVEAETAHWEHTLTGAGTLRLDRGRD
FT                   LQGDAGRISLDLAPHTTEALLTRLPGGVNASVHDVLLTAFAFAVAGWRRGRGEDPDAPV
FT                   VLDLESHGRHEEAVPGAELSRTAGWFTALHPVRLAPDVTDWARLHQDGDALRDGLKQVK
FT                   EQLRSVPGDGLGHGLLRHLNPTAGPRLARLPEPDFGFNYLGRRVTPATGTPEPWTVTGG
FT                   GLAASRPTAPMAHAVELSAVVHEGADGPRLRAEWTYARRLVPDHDARRLAEQWFRALEA
FT                   LVEQADRAGTGGLTPSDVTLGSLSQSEIEEFESDLESEWEIEQ"
FT                   /gene="SCO3230"
FT                   /protein_id="CAB38518.1"
FT   misc_feature    23899..25089
FT                   /note="Pfam match to entry PF00668 DUF4, Domain of unknown
FT                   function, score 80.00, E-value 5e-20"
FT                   /gene="SCO3230"
FT                   /gene_synonym="cdaPSI"
FT                   /gene_synonym="SCE63.03c"
FT   CDS_motif       23914..23952
FT                   /note="NRPS/PKS Motif: C1_starter_004-017 (e-value: 0.03,
FT                   bit-score: 7.6);"
FT   CDS_motif       23974..24087
FT                   /note="NRPS/PKS Motif: C2_starter_024-063 (e-value:
FT                   8.9e-13, bit-score: 40.8);"
FT   misc_feature    24295..24327
FT                   /note="PS00639 Eukaryotic thiol (cysteine) proteases
FT                   histidine active site."
FT                   /gene="SCO3230"
FT                   /gene_synonym="cdaPSI"
FT                   /gene_synonym="SCE63.03c"
FT   CDS_motif       24349..24414
FT                   /note="NRPS/PKS Motif: C3_starter_134-155 (e-value:
FT                   2.9e-08, bit-score: 26.6);"
FT   CDS_motif       24742..24831
FT                   /note="NRPS/PKS Motif: C5_starter_265-294 (e-value:
FT                   9.7e-12, bit-score: 37.2);"
FT   CDS_motif       24883..24981
FT                   /note="NRPS/PKS Motif: C67_starter_14fromHMM (e-value:
FT                   9.7e-08, bit-score: 24.6);"
FT   misc_feature    25375..26607
FT                   /note="Pfam match to entry PF00501 AMP-binding, AMP-binding
FT                   enzyme, score 601.30, E-value 5.6e-177"
FT                   /gene="SCO3230"
FT                   /gene_synonym="cdaPSI"
FT                   /gene_synonym="SCE63.03c"
FT   CDS_motif       25498..25539
FT                   /note="NRPS/PKS Motif: NRPS-A_a2 (e-value: 0.0001,
FT                   bit-score: 15.6);"
FT   CDS_motif       25750..25809
FT                   /note="NRPS/PKS Motif: NRPS-A_a3 (e-value: 2.6e-10,
FT                   bit-score: 32.1);"
FT   misc_feature    25756..25791
FT                   /note="PS00455 Putative AMP-binding domain signature."
FT                   /gene="SCO3230"
FT                   /gene_synonym="cdaPSI"
FT                   /gene_synonym="SCE63.03c"
FT   CDS_motif       26191..26214
FT                   /note="NRPS/PKS Motif: NRPS-A_a5 (e-value: 1.7, bit-score:
FT                   2.4);"
FT   CDS_motif       26326..26415
FT                   /note="NRPS/PKS Motif: NRPS-A_a6 (e-value: 5.9e-16,
FT                   bit-score: 50.5);"
FT   CDS_motif       26500..26565
FT                   /note="NRPS/PKS Motif: NRPS-A_a8 (e-value: 9.3e-12,
FT                   bit-score: 36.9);"
FT   CDS_motif       27085..27111
FT                   /note="NRPS/PKS Motif: NRPS-A_a10 (e-value: 0.84,
FT                   bit-score: 3.2);"
FT   misc_feature    27166..27360
FT                   /note="Pfam match to entry PF00550 pp-binding, Phosphopante
FT                   theine attachment site, score 74.30, E-value 6.3e-19"
FT                   /gene="SCO3230"
FT                   /gene_synonym="cdaPSI"
FT                   /gene_synonym="SCE63.03c"
FT   CDS_motif       27169..27201
FT                   /note="NRPS/PKS Motif: Cy4 (e-value: 0.09, bit-score:
FT                   6.1);"
FT   misc_feature    27235..27282
FT                   /note="PS00012 Phosphopantetheine attachment site."
FT                   /gene="SCO3230"
FT                   /gene_synonym="cdaPSI"
FT                   /gene_synonym="SCE63.03c"
FT   misc_feature    27403..28605
FT                   /note="Pfam match to entry PF00668 DUF4, Domain of unknown
FT                   function, score 318.40, E-value 8.5e-92"
FT                   /gene="SCO3230"
FT                   /gene_synonym="cdaPSI"
FT                   /gene_synonym="SCE63.03c"
FT   CDS_motif       27424..27456
FT                   /note="NRPS/PKS Motif: C1_LCL_004-017 (e-value: 0.046,
FT                   bit-score: 6.9);"
FT   CDS_motif       27475..27591
FT                   /note="NRPS/PKS Motif: C2_LCL_024-062 (e-value: 1.1e-18,
FT                   bit-score: 59.6);"
FT   CDS_motif       27793..27858
FT                   /note="NRPS/PKS Motif: C3_LCL_132-143 (e-value: 4.4e-09,
FT                   bit-score: 28.8);"
FT   CDS_motif       27907..27945
FT                   /note="NRPS/PKS Motif: C4_LCL_164-176 (e-value: 0.0001,
FT                   bit-score: 14.9);"
FT   CDS_motif       28228..28317
FT                   /note="NRPS/PKS Motif: C5_LCL_267-296 (e-value: 1.3e-14,
FT                   bit-score: 46.5);"
FT   CDS_motif       28366..28485
FT                   /note="NRPS/PKS Motif: C67_LCL_14fromHMM (e-value: 3.3e-22,
FT                   bit-score: 70.9);"
FT   misc_feature    28972..30249
FT                   /note="Pfam match to entry PF00501 AMP-binding, AMP-binding
FT                   enzyme, score 563.60, E-value 1.2e-165"
FT                   /gene="SCO3230"
FT                   /gene_synonym="cdaPSI"
FT                   /gene_synonym="SCE63.03c"
FT   CDS_motif       29095..29136
FT                   /note="NRPS/PKS Motif: NRPS-A_a2 (e-value: 0.00021,
FT                   bit-score: 14.7);"
FT   CDS_motif       29371..29430
FT                   /note="NRPS/PKS Motif: NRPS-A_a3 (e-value: 9.8e-10,
FT                   bit-score: 30.4);"
FT   misc_feature    29377..29412
FT                   /note="PS00455 Putative AMP-binding domain signature."
FT                   /gene="SCO3230"
FT                   /gene_synonym="cdaPSI"
FT                   /gene_synonym="SCE63.03c"
FT   CDS_motif       29815..29838
FT                   /note="NRPS/PKS Motif: NRPS-A_a5 (e-value: 8.8, bit-score:
FT                   0.5);"
FT   CDS_motif       29959..30045
FT                   /note="NRPS/PKS Motif: NRPS-A_a6 (e-value: 4.3e-15,
FT                   bit-score: 47.8);"
FT   CDS_motif       30142..30207
FT                   /note="NRPS/PKS Motif: NRPS-A_a8 (e-value: 6.1e-12,
FT                   bit-score: 37.4);"
FT   CDS_motif       30415..30441
FT                   /note="NRPS/PKS Motif: NRPS-A_a10 (e-value: 18.0,
FT                   bit-score: -0.2);"
FT   misc_feature    30496..30690
FT                   /note="Pfam match to entry PF00550 pp-binding, Phosphopante
FT                   theine attachment site, score 82.80, E-value 2.8e-21"
FT                   /gene="SCO3230"
FT                   /gene_synonym="cdaPSI"
FT                   /gene_synonym="SCE63.03c"
FT   CDS_motif       30499..30531
FT                   /note="NRPS/PKS Motif: Cy4 (e-value: 0.17, bit-score:
FT                   5.2);"
FT   misc_feature    30565..30612
FT                   /note="PS00012 Phosphopantetheine attachment site."
FT                   /gene="SCO3230"
FT                   /gene_synonym="cdaPSI"
FT                   /gene_synonym="SCE63.03c"
FT   misc_feature    30733..31917
FT                   /note="Pfam match to entry PF00668 DUF4, Domain of unknown
FT                   function, score 302.10, E-value 6.9e-87"
FT                   /gene="SCO3230"
FT                   /gene_synonym="cdaPSI"
FT                   /gene_synonym="SCE63.03c"
FT   CDS_motif       30754..30786
FT                   /note="NRPS/PKS Motif: C1_LCL_004-017 (e-value: 0.016,
FT                   bit-score: 8.1);"
FT   CDS_motif       30805..30918
FT                   /note="NRPS/PKS Motif: C2_LCL_024-062 (e-value: 4.7e-19,
FT                   bit-score: 60.8);"
FT   CDS_motif       31123..31188
FT                   /note="NRPS/PKS Motif: C3_LCL_132-143 (e-value: 7.5e-11,
FT                   bit-score: 34.4);"
FT   CDS_motif       31237..31275
FT                   /note="NRPS/PKS Motif: C4_LCL_164-176 (e-value: 0.0001,
FT                   bit-score: 14.9);"
FT   CDS_motif       31543..31632
FT                   /note="NRPS/PKS Motif: C5_LCL_267-296 (e-value: 1.8e-12,
FT                   bit-score: 39.6);"
FT   CDS_motif       31681..31800
FT                   /note="NRPS/PKS Motif: C67_LCL_14fromHMM (e-value: 6.9e-21,
FT                   bit-score: 66.7);"
FT   misc_feature    32239..33438
FT                   /note="Pfam match to entry PF00501 AMP-binding, AMP-binding
FT                   enzyme, score 484.60, E-value 8.1e-142"
FT                   /gene="SCO3230"
FT                   /gene_synonym="cdaPSI"
FT                   /gene_synonym="SCE63.03c"
FT   CDS_motif       32362..32403
FT                   /note="NRPS/PKS Motif: NRPS-A_a2 (e-value: 0.0024,
FT                   bit-score: 11.5);"
FT   misc_feature    32491..32508
FT                   /note="PS00343 Gram-positive cocci surface proteins 'anchor
FT                   ing' hexapeptide."
FT                   /gene="SCO3230"
FT                   /gene_synonym="cdaPSI"
FT                   /gene_synonym="SCE63.03c"
FT   CDS_motif       32617..32676
FT                   /note="NRPS/PKS Motif: NRPS-A_a3 (e-value: 2.3e-09,
FT                   bit-score: 29.3);"
FT   misc_feature    32623..32658
FT                   /note="PS00455 Putative AMP-binding domain signature."
FT                   /gene="SCO3230"
FT                   /gene_synonym="cdaPSI"
FT                   /gene_synonym="SCE63.03c"
FT   CDS_motif       33025..33057
FT                   /note="NRPS/PKS Motif: NRPS-A_a5 (e-value: 0.035,
FT                   bit-score: 7.2);"
FT   CDS_motif       33157..33246
FT                   /note="NRPS/PKS Motif: NRPS-A_a6 (e-value: 8.7e-14,
FT                   bit-score: 43.6);"
FT   CDS_motif       33331..33396
FT                   /note="NRPS/PKS Motif: NRPS-A_a8 (e-value: 2.1e-10,
FT                   bit-score: 32.7);"
FT   CDS_motif       33610..33636
FT                   /note="NRPS/PKS Motif: NRPS-A_a10 (e-value: 0.84,
FT                   bit-score: 3.2);"
FT   misc_feature    33691..33873
FT                   /note="Pfam match to entry PF00550 pp-binding, Phosphopante
FT                   theine attachment site, score 59.80, E-value 6.3e-15"
FT                   /gene="SCO3230"
FT                   /gene_synonym="cdaPSI"
FT                   /gene_synonym="SCE63.03c"
FT   misc_feature    33760..33807
FT                   /note="PS00012 Phosphopantetheine attachment site."
FT                   /gene="SCO3230"
FT                   /gene_synonym="cdaPSI"
FT                   /gene_synonym="SCE63.03c"
FT   misc_feature    33931..35139
FT                   /note="Pfam match to entry PF00668 DUF4, Domain of unknown
FT                   function, score 166.50, E-value 4.5e-46"
FT                   /gene="SCO3230"
FT                   /gene_synonym="cdaPSI"
FT                   /gene_synonym="SCE63.03c"
FT   CDS_motif       33994..34104
FT                   /note="NRPS/PKS Motif: C2_LCL_024-062 (e-value: 1.8e-08,
FT                   bit-score: 26.8);"
FT   CDS_motif       34318..34383
FT                   /note="NRPS/PKS Motif: NRPS-E2 (e-value: 2.4e-09,
FT                   bit-score: 29.5);"
FT   CDS_motif       34786..34833
FT                   /note="NRPS/PKS Motif: NRPS-E5 (e-value: 2.1e-07,
FT                   bit-score: 23.1);"
FT   CDS_motif       34888..34950
FT                   /note="NRPS/PKS Motif: NRPS-E6 (e-value: 1e-09, bit-score:
FT                   30.5);"
FT   misc_feature    35356..36507
FT                   /note="Pfam match to entry PF00668 DUF4, Domain of unknown
FT                   function, score 275.20, E-value 8.5e-79"
FT                   /gene="SCO3230"
FT                   /gene_synonym="cdaPSI"
FT                   /gene_synonym="SCE63.03c"
FT   CDS_motif       35431..35550
FT                   /note="NRPS/PKS Motif: C2_DCL_024-062 (e-value: 4.9e-14,
FT                   bit-score: 44.6);"
FT   CDS_motif       35770..35835
FT                   /note="NRPS/PKS Motif: C3_DCL_135-156 (e-value: 1.2e-10,
FT                   bit-score: 33.8);"
FT   CDS_motif       36145..36240
FT                   /note="NRPS/PKS Motif: C5_DCL_263-294 (e-value: 8.7e-22,
FT                   bit-score: 69.6);"
FT   CDS_motif       36289..36402
FT                   /note="NRPS/PKS Motif: C67_DCL_14fromHMM (e-value: 1.5e-18,
FT                   bit-score: 59.2);"
FT   misc_feature    36796..37929
FT                   /note="Pfam match to entry PF00501 AMP-binding, AMP-binding
FT                   enzyme, score 435.90, E-value 3.5e-127"
FT                   /gene="SCO3230"
FT                   /gene_synonym="cdaPSI"
FT                   /gene_synonym="SCE63.03c"
FT   CDS_motif       36919..36960
FT                   /note="NRPS/PKS Motif: NRPS-A_a2 (e-value: 0.00024,
FT                   bit-score: 14.5);"
FT   CDS_motif       37117..37176
FT                   /note="NRPS/PKS Motif: NRPS-A_a3 (e-value: 6.6e-10,
FT                   bit-score: 30.9);"
FT   misc_feature    37123..37158
FT                   /note="PS00455 Putative AMP-binding domain signature."
FT                   /gene="SCO3230"
FT                   /gene_synonym="cdaPSI"
FT                   /gene_synonym="SCE63.03c"
FT   CDS_motif       37510..37536
FT                   /note="NRPS/PKS Motif: NRPS-A_a5 (e-value: 0.45, bit-score:
FT                   4.1);"
FT   CDS_motif       37648..37734
FT                   /note="NRPS/PKS Motif: NRPS-A_a6 (e-value: 1.8e-15,
FT                   bit-score: 49.0);"
FT   CDS_motif       37822..37887
FT                   /note="NRPS/PKS Motif: NRPS-A_a8 (e-value: 3.4e-10,
FT                   bit-score: 32.0);"
FT   CDS_motif       38101..38127
FT                   /note="NRPS/PKS Motif: NRPS-A_a10 (e-value: 3.0, bit-score:
FT                   1.8);"
FT   misc_feature    38182..38376
FT                   /note="Pfam match to entry PF00550 pp-binding, Phosphopante
FT                   theine attachment site, score 87.10, E-value 1.8e-22"
FT                   /gene="SCO3230"
FT                   /gene_synonym="cdaPSI"
FT                   /gene_synonym="SCE63.03c"
FT   CDS_motif       38185..38217
FT                   /note="NRPS/PKS Motif: Cy4 (e-value: 0.053, bit-score:
FT                   6.8);"
FT   misc_feature    38419..39609
FT                   /note="Pfam match to entry PF00668 DUF4, Domain of unknown
FT                   function, score 322.70, E-value 4.3e-93"
FT                   /gene="SCO3230"
FT                   /gene_synonym="cdaPSI"
FT                   /gene_synonym="SCE63.03c"
FT   CDS_motif       38440..38472
FT                   /note="NRPS/PKS Motif: C1_LCL_004-017 (e-value: 0.016,
FT                   bit-score: 8.1);"
FT   CDS_motif       38491..38604
FT                   /note="NRPS/PKS Motif: C2_LCL_024-062 (e-value: 3.9e-16,
FT                   bit-score: 51.4);"
FT   CDS_motif       38809..38874
FT                   /note="NRPS/PKS Motif: C3_LCL_132-143 (e-value: 5.1e-08,
FT                   bit-score: 25.5);"
FT   CDS_motif       38923..38961
FT                   /note="NRPS/PKS Motif: C4_LCL_164-176 (e-value: 0.00011,
FT                   bit-score: 14.8);"
FT   CDS_motif       39229..39318
FT                   /note="NRPS/PKS Motif: C5_LCL_267-296 (e-value: 1.3e-13,
FT                   bit-score: 43.3);"
FT   CDS_motif       39367..39486
FT                   /note="NRPS/PKS Motif: C67_LCL_14fromHMM (e-value: 2.2e-23,
FT                   bit-score: 74.8);"
FT   misc_feature    39916..41049
FT                   /note="Pfam match to entry PF00501 AMP-binding, AMP-binding
FT                   enzyme, score 453.50, E-value 1.8e-132"
FT                   /gene="SCO3230"
FT                   /gene_synonym="cdaPSI"
FT                   /gene_synonym="SCE63.03c"
FT   CDS_motif       40039..40080
FT                   /note="NRPS/PKS Motif: NRPS-A_a2 (e-value: 0.00024,
FT                   bit-score: 14.5);"
FT   CDS_motif       40237..40296
FT                   /note="NRPS/PKS Motif: NRPS-A_a3 (e-value: 6.6e-10,
FT                   bit-score: 30.9);"
FT   misc_feature    40243..40278
FT                   /note="PS00455 Putative AMP-binding domain signature."
FT                   /gene="SCO3230"
FT                   /gene_synonym="cdaPSI"
FT                   /gene_synonym="SCE63.03c"
FT   CDS_motif       40630..40656
FT                   /note="NRPS/PKS Motif: NRPS-A_a5 (e-value: 0.45, bit-score:
FT                   4.1);"
FT   CDS_motif       40768..40854
FT                   /note="NRPS/PKS Motif: NRPS-A_a6 (e-value: 1.8e-15,
FT                   bit-score: 49.0);"
FT   CDS_motif       40942..41007
FT                   /note="NRPS/PKS Motif: NRPS-A_a8 (e-value: 3.4e-10,
FT                   bit-score: 32.0);"
FT   CDS_motif       41221..41247
FT                   /note="NRPS/PKS Motif: NRPS-A_a10 (e-value: 3.0, bit-score:
FT                   1.8);"
FT   misc_feature    41302..41496
FT                   /note="Pfam match to entry PF00550 pp-binding, Phosphopante
FT                   theine attachment site, score 84.80, E-value 7.6e-22"
FT                   /gene="SCO3230"
FT                   /gene_synonym="cdaPSI"
FT                   /gene_synonym="SCE63.03c"
FT   CDS_motif       41305..41337
FT                   /note="NRPS/PKS Motif: Cy4 (e-value: 0.16, bit-score:
FT                   5.3);"
FT   misc_feature    41371..41418
FT                   /note="PS00012 Phosphopantetheine attachment site."
FT                   /gene="SCO3230"
FT                   /gene_synonym="cdaPSI"
FT                   /gene_synonym="SCE63.03c"
FT   misc_feature    41539..42723
FT                   /note="Pfam match to entry PF00668 DUF4, Domain of unknown
FT                   function, score 313.50, E-value 2.5e-90"
FT                   /gene="SCO3230"
FT                   /gene_synonym="cdaPSI"
FT                   /gene_synonym="SCE63.03c"
FT   CDS_motif       41560..41592
FT                   /note="NRPS/PKS Motif: C1_LCL_004-017 (e-value: 0.016,
FT                   bit-score: 8.1);"
FT   CDS_motif       41611..41724
FT                   /note="NRPS/PKS Motif: C2_LCL_024-062 (e-value: 5.6e-18,
FT                   bit-score: 57.3);"
FT   misc_feature    41827..41859
FT                   /note="PS00626 Regulator of chromosome condensation (RCC1)
FT                   signature 2."
FT                   /gene="SCO3230"
FT                   /gene_synonym="cdaPSI"
FT                   /gene_synonym="SCE63.03c"
FT   CDS_motif       41929..41994
FT                   /note="NRPS/PKS Motif: C3_LCL_132-143 (e-value: 2.8e-07,
FT                   bit-score: 23.1);"
FT   CDS_motif       42043..42081
FT                   /note="NRPS/PKS Motif: C4_LCL_164-176 (e-value: 1.8e-05,
FT                   bit-score: 17.3);"
FT   CDS_motif       42349..42438
FT                   /note="NRPS/PKS Motif: C5_LCL_267-296 (e-value: 1.9e-15,
FT                   bit-score: 49.1);"
FT   CDS_motif       42487..42603
FT                   /note="NRPS/PKS Motif: C67_LCL_14fromHMM (e-value: 4.2e-23,
FT                   bit-score: 73.8);"
FT   misc_feature    43030..44289
FT                   /note="Pfam match to entry PF00501 AMP-binding, AMP-binding
FT                   enzyme, score 471.80, E-value 5.5e-138"
FT                   /gene="SCO3230"
FT                   /gene_synonym="cdaPSI"
FT                   /gene_synonym="SCE63.03c"
FT   CDS_motif       43153..43191
FT                   /note="NRPS/PKS Motif: NRPS-A_a2 (e-value: 0.00076,
FT                   bit-score: 13.0);"
FT   CDS_motif       43447..43506
FT                   /note="NRPS/PKS Motif: NRPS-A_a3 (e-value: 2.8e-09,
FT                   bit-score: 29.0);"
FT   misc_feature    43453..43488
FT                   /note="PS00455 Putative AMP-binding domain signature."
FT                   /gene="SCO3230"
FT                   /gene_synonym="cdaPSI"
FT                   /gene_synonym="SCE63.03c"
FT   CDS_motif       43870..43896
FT                   /note="NRPS/PKS Motif: NRPS-A_a5 (e-value: 0.28, bit-score:
FT                   4.7);"
FT   CDS_motif       44008..44097
FT                   /note="NRPS/PKS Motif: NRPS-A_a6 (e-value: 6.2e-15,
FT                   bit-score: 47.3);"
FT   CDS_motif       44182..44247
FT                   /note="NRPS/PKS Motif: NRPS-A_a8 (e-value: 2.9e-11,
FT                   bit-score: 35.3);"
FT   CDS_motif       44467..44493
FT                   /note="NRPS/PKS Motif: NRPS-A_a10 (e-value: 0.84,
FT                   bit-score: 3.2);"
FT   misc_feature    44548..44739
FT                   /note="Pfam match to entry PF00550 pp-binding, Phosphopante
FT                   theine attachment site, score 69.40, E-value 1.5e-17"
FT                   /gene="SCO3230"
FT                   /gene_synonym="cdaPSI"
FT                   /gene_synonym="SCE63.03c"
FT   CDS_motif       44551..44583
FT                   /note="NRPS/PKS Motif: Cy4 (e-value: 0.19, bit-score:
FT                   5.0);"
FT   misc_feature    44617..44664
FT                   /note="PS00012 Phosphopantetheine attachment site."
FT                   /gene="SCO3230"
FT                   /gene_synonym="cdaPSI"
FT                   /gene_synonym="SCE63.03c"
FT   misc_feature    44788..46041
FT                   /note="Pfam match to entry PF00668 DUF4, Domain of unknown
FT                   function, score 108.80, E-value 1.1e-28"
FT                   /gene="SCO3230"
FT                   /gene_synonym="cdaPSI"
FT                   /gene_synonym="SCE63.03c"
FT   CDS_motif       44890..44964
FT                   /note="NRPS/PKS Motif: C2_starter_024-063 (e-value:
FT                   0.00015, bit-score: 14.5);"
FT   CDS_motif       45205..45270
FT                   /note="NRPS/PKS Motif: NRPS-E2 (e-value: 4.8e-07,
FT                   bit-score: 22.3);"
FT   CDS_motif       45670..45717
FT                   /note="NRPS/PKS Motif: NRPS-E5 (e-value: 3.7e-06,
FT                   bit-score: 19.3);"
FT   CDS_motif       45787..45849
FT                   /note="NRPS/PKS Motif: NRPS-E6 (e-value: 4.2e-09,
FT                   bit-score: 28.6);"
FT   gene            46275..57287
FT                   /gene="SCO3231"
FT                   /gene_synonym="cdaPS2"
FT                   /gene_synonym="SCE63.02c"
FT   CDS             46275..57287
FT                   /product="CDA peptide synthetase II"
FT                   /codon_start=1
FT                   /gene_synonym="cdaPS2"
FT                   /gene_synonym="SCE63.02c"
FT                   /transl_table=11
FT                   /note="SCE63.02c, cdaPS2, CDA peptide synthetase II, len:
FT                   3670 aa; part of the calcium-dependent antibiotic (CDA)
FT                   biosynthetic cluster from Streptomyces coelicolor. CDA is a
FT                   peptide antibiotic which is synthesised non-ribosomally by
FT                   a putative multifunctional peptide synthetase enzyme. This
FT                   CDS encodes a subunit of this enzyme and is suspected to be
FT                   responsible for the addition of 3 amino acids to the
FT                   peptide antibiotic. This ORF overlaps the upstream (cdaPSI)
FT                   and downstream (cdaPSIII) ORFs by one base indicating
FT                   possible translational coupling of all three. Contains four
FT                   separate Pfam matches to entry PF00668 DUF4, Domain of
FT                   unknown function (U), three separate Pfam matches to entry
FT                   PF00501 AMP-binding, AMP-binding enzyme (A) and three
FT                   separate Pfam matches to entry PF00550 pp-binding,
FT                   Phosphopantetheine attachment site (P). These Pfam matches
FT                   cover the full length of the protein in the following order
FT                   from N to C-terminal U-A-P-U-A-P-U-A-P-U. The first and
FT                   third Pfam matches to entry PF00501 also contain Prosite
FT                   matches to PS00455 Putative AMP-binding domain signature.
FT                   All three Pfam matches to entry PF00550 also contain
FT                   Prosite matches to PS00012 Phosphopantetheine attachment
FT                   site."
FT                   /note="smCOG:
FT                   SMCOG1127:condensation_domain-containing_protein (Score:
FT                   358.0; E-value: 1.4e-108);"
FT                   /db_xref="GI:4481933"
FT                   /db_xref="GOA:Q9Z4X5"
FT                   /db_xref="HSSP:1AMU"
FT                   /db_xref="InterPro:IPR000873"
FT                   /db_xref="InterPro:IPR001242"
FT                   /db_xref="InterPro:IPR006162"
FT                   /db_xref="InterPro:IPR006163"
FT                   /db_xref="InterPro:IPR009081"
FT                   /db_xref="InterPro:IPR010060"
FT                   /db_xref="InterPro:IPR010071"
FT                   /db_xref="InterPro:IPR020806"
FT                   /db_xref="InterPro:IPR020845"
FT                   /db_xref="UniProtKB/TrEMBL:Q9Z4X5"
FT                   /sec_met="Type: nrps"
FT                   /sec_met="Domains detected: Condensation (E-value: 2.5e-68,
FT                   bitscore: 221.7, seeds: 42); Condensation (E-value:
FT                   1.4e-74, bitscore: 242.2, seeds: 42); Condensation
FT                   (E-value: 7.6e-74, bitscore: 239.8, seeds: 42);
FT                   Condensation (E-value: 4e-34, bitscore: 109.3, seeds: 42);
FT                   AMP-binding (E-value: 5.3e-102, bitscore: 332.8, seeds:
FT                   400); AMP-binding (E-value: 2.8e-105, bitscore: 343.6,
FT                   seeds: 400); AMP-binding (E-value: 7.9e-107, bitscore:
FT                   348.7, seeds: 400); PP-binding (E-value: 5.7e-15, bitscore:
FT                   47.1, seeds: 164); PP-binding (E-value: 1.7e-17, bitscore:
FT                   55.1, seeds: 164); PP-binding (E-value: 2.7e-15, bitscore:
FT                   48.1, seeds: 164)"
FT                   /sec_met="Kind: biosynthetic"
FT                   /sec_met="NRPS/PKS subtype: Glycopeptide NRPS"
FT                   /sec_met="NRPS/PKS Domain: NRPS-COM_Nterm (7-34). E-value:
FT                   4.4e-07. Score: 20.3;"
FT                   /sec_met="NRPS/PKS Domain: Cglyc (11-309). E-value:
FT                   9.2e-120. Score: 390.6;"
FT                   /sec_met="NRPS/PKS Domain: AMP-binding (492-869). E-value:
FT                   4.9e-102. Score: 332.8;"
FT                   /sec_met="NRPS/PKS Domain: PCP (950-1018). E-value:
FT                   6.6e-27. Score: 84.8;"
FT                   /sec_met="NRPS/PKS Domain: Condensation_LCL (1032-1333).
FT                   E-value: 1.8e-123. Score: 402.6;"
FT                   /sec_met="NRPS/PKS Domain: AMP-binding (1525-1908).
FT                   E-value: 2.6e-105. Score: 343.6;"
FT                   /sec_met="NRPS/PKS Domain: PCP (1999-2068). E-value:
FT                   4.6e-29. Score: 91.8;"
FT                   /sec_met="NRPS/PKS Domain: Condensation_LCL (2081-2382).
FT                   E-value: 1.5e-122. Score: 399.5;"
FT                   /sec_met="NRPS/PKS Domain: AMP-binding (2588-2996).
FT                   E-value: 7.3e-107. Score: 348.7;"
FT                   /sec_met="NRPS/PKS Domain: PCP (3082-3148). E-value:
FT                   7.5e-24. Score: 75.0;"
FT                   /sec_met="NRPS/PKS Domain: Epimerization (3177-3482).
FT                   E-value: 4.1e-129. Score: 422.8;"
FT                   /translation="MSQQPTRARGKIEDILPLSPLQEGFVFLGLLHTEGPDLYIGQVAF
FT                   DLEGPFDGARMREAARALLRRHANLRAGFRQRKNGAWAQLVLRDVDLPWQDADLSTLSE
FT                   EERRAEADRLAAADRARRFDLGRPPLLRFTAIRLSADRVRLVMTNHHIVLDGWSMPVLL
FT                   RELMALYAAEGDPSALPRVRPYRDYLAWLDARDRDAARDAWRRSLSGLDEATLLAPDAG
FT                   PASTAPSQVSFTVDSEVSGALSAWARGQGVTMNTVVQGAWALALAQATGRDDVVFGATV
FT                   SGRPPELPGVESMIGLFINTLPVRARLDQAEPLGDLFRRLQNEQARLLDHQWPGLADIQ
FT                   HWAGHGELFDTAMVFQNYPVEEGDLTAPADPDRLRVASADIKGGTHFAVNVVATMRGAE
FT                   LSFRVDYRPDLYDEAYARDFGRRMLRVLETLISDPDRPVAHLDTLDPAVRERVLVEWNG
FT                   APTQLPGTPLHELISEQARLTPDAVAVVCDGTSLTYAELDGRANQLARHLLERGLGAED
FT                   FVAIALHKSLDAVTSMLAVLKTGAAYLPIDPDYPAERITYMLDDARPALTLREPVPAAA
FT                   YGHRPTDDVTDAERRTPWSALHAAYMIYTSGSTGRPKGVVIEHHALATYLHRARNTYTA
FT                   MTGVTVLHSPLAFDLTITALWTPLTAGGTVHLTSLEEAEVQPSLIKATPSHLPLLTNLA
FT                   ATASPSHTLILGGEALHTDQLTDWRTQHPGAQIINAYGPTESTVNITDHRLDGTEEGPV
FT                   PIGRPFANTQVYVLDSALRPVAPGTTGELYLAGEQLARGYLGRPALTAERFTANPHSSV
FT                   PGARMYRTGDLAHWNHHGHLTYDGRADHQIKLRGHRIEPGEIETTLTAQTGITQATVQL
FT                   REDQPGDQRLVAYLVTSTGYDENTVRDALVSALPDYMVPSALVTLDALPLTPNGKLDRT
FT                   ALPAPAYSASTTGRTPRTPREEILCTLYSEILSVNTVGIDDSFFDLGGHSLLATRLVSR
FT                   IRTTLGRELPIRQLFETPTVAGLSRALDTSGTLRTALTARPRPERIPLSYAQQRLWFLH
FT                   QLEGPTATYNIPTTLRLTGTLDTDALQSAFNDLLARHESLRTTYTEDDQGAQQIVLPVE
FT                   AVATPFAVVDVAAEDVAERVAEAAAHAFDLGAEIPVRARLFRVSEREHVLLLLVHHIAS
FT                   DAWSRGPLAQDLTAAYTARCADDAPAWQPLPVQYADYALWQQEILGDDTDPDTLAGRQL
FT                   AYWKQQLAGLPEQLDLPTDRPRPATADHTGDRVTFTVPADLHTRLTELARETNTTAFMV
FT                   IQAALAALLTRHGAGEDIPIGTPVAGRTDDATDHLIGFFVNTLVLRTDTSGNPTFRDLL
FT                   TRVRDTDLTAYTHQDLPFERLVEALNPTRSLTHHPLFQTMLTLHNTQGTKTDRFAGLAA
FT                   EVVASESVSARFDLSFALAEHFGADHSCAGMSGGVTYSTALFDRATVRDLADRLVRLLA
FT                   AAVAHPGRSVGQLEIMDAAERRLVLQEWNDTAAEPPAASVTGLFERQARRSPGATALEF
FT                   GEVRLSYAELNARANRLARHLVARGAAPGRFVAVALPRSAELVVTLLAVLKSGAAYLPI
FT                   DPHYPADRVEYMLADAGPALTVTEPVAEAGLSGYGDADLGADELRGPVHGAHPAYTIYT
FT                   SGSTGRPKGVVVPRGALDNFLADMGRRFTPGSGDRLLAVTTVGFDIAGLEIFLPLLHGA
FT                   VLVLADEETARDPHALLHRVSASGITMVQATPSLWQGVAAVAGDELAGVRVLVGGEALP
FT                   SELARALTDRARSVTNLYGPTEATIWATAADVAESGPVIGRPLANTSAYVLDSALRPVP
FT                   VGVPGELYLAGEQLAQGYHLRPALTSERFTADPYGPAGTRMYRTGDLVCRRRDGALRYL
FT                   SRVDQQVKLRGFRIELGEIEAELSRHPAVAESAVTVREDRPGDRRLVGYVVPKGPEGPA
FT                   GPTGPVPSARELRERLRGRLPEFMVPTAFVVLDALPLTPNRKLDRKALPAPEYDGEPVG
FT                   RGPRDPREEILCALFAEVLGVARVGIDDGFFDLGGHSLLATRLVSRIRTALGVELSVRQ
FT                   FFETPTIAGLSGALDRAAGARAPLAARPRPERVPLSPAQQRLWFLHQFEGPSATYNMPT
FT                   ALRLSGPVDRAALERAIGDVLVRHESLRTVFAADDGGSWQVVLPADRAVGRLDVVDVTA
FT                   GEVAERVGEAARHAFDLTADIPFLARLFRVSDTEHVLLLLIHHIAGDGWSMAPLARDLT
FT                   AAYAARCAGAAPDWEPLPVQYADYALWQREVLGDESDPDSVAARQLAYWKDALAGLPEQ
FT                   LELPTDRPRPATAGYTGDRIAFTVPTALHARLTELARSTHSSLFMVVQAAFATLLTRLG
FT                   AGEDIPVGTAVAGRNDAATEDLVGFFVNTLVLRTDTGGNPTFRELLGRVRERDLAAYAH
FT                   QDVPFERLVEALNPARSLAHHPLYQVMITFNNTAGAGDRTAPASPDTPDVSGQAGALLN
FT                   ATRMTAGTGVAKFDLALTFGERHDPSGGPAGMRGSLEYRTELFDRETAESVISRLLGVL
FT                   GSVTADPDRPIGGIGLLDPAERRQVLREWNDTARPQREGTLPRLFEEQVARTPRRPAFS
FT                   AAGTTLTYAELNSRANRLAHLLAESGAGPEQVVAISLPPSVEMGVAVLAVLKTGAAYLP
FT                   VDPGSPRERIATMAEDAAPVCALTTSAVPAGVFPAELPRLLLDDPDVTARLAAQPAHDL
FT                   TDEDRTQPLSPWNAAYIIYTSGSTGRPKGVLVEHQPVLNYLAVSAELYPGVAGNALLHS
FT                   PLSFDLTVTGLFAPLLNGGCVHLADLEELHARALDGEVPDLPQTTFLKATPSHLPLITG
FT                   LPGVCVPDGELVLGGESLTGRAVRTLLAAHPGARVLNEYGPTETIVGCTTWRVEAPDDL
FT                   ADGVLTIGRPFPNTRMLVLDPYLQPVPAGVPGELYVSGVQLARGYLNRPGQSASRFVAN
FT                   PFEGPGERMYRTGDIVRWNRRGDLEFISRVDDQVKIRGFRVELGEVESALSRQPGVPEA
FT                   VAVVREDRPGDRRLVAYLVTGAGPVPVPSDEELRERLRETLPDYMVPSAFVRLPELPLT
FT                   GNGKLDRGRLPAPDYAAAGTGRAPVTAREELLCALFAEALGLESVGVDDGFFDLGGDSI
FT                   LSIQLVSRARAKGLTLSVRDVFEHQSVARVAEALELAEAQAADGAAGASAGAVPGAAEE
FT                   EAAASGPVPATPIMGWFAALGGPVAPFNQSVVVSVPADLDAERLVAALGALLDRHDSLR
FT                   LRVAADWSMSVPEPEPGGTDAAGLLTRRAAGDVDDAGLHALLAEAGAAERDRLSPADGR
FT                   MLRACHVDRGPDRPGLLVLVAHHLAVDAVSWRLLVPDLAAAYEGRPLSPAGTGWRRWAS
FT                   ALRDLAGSPVTEAETDHWLDAARPAAEPADPVLDPARDTHARSGQVVLDLDPDTTDALL
FT                   TWVPGVFRAEINDLLLTAFGLAVADWRRDRGARGTAPVTVDLESHGRHEHLVPGADLTR
FT                   TTGWFTSMHPVPLHPEVDDPDWAEVWDGGAAAGRALKRVKEQLRAVPRDGVGHGLLRHL
FT                   NPRTRDRFAALPTPAYGFNYLGRHTGGRGGGAPGGGAGPEPWSVLGRGVAGQHPDTPLA
FT                   HPVELVAGAHDTDAGPTLHSVWTYADAVLSETEVRRLGEGWFRALKALVEHAGRPEASG
FT                   LTPSDVSLTSLSEDDISRLESEWGSL"
FT                   /gene="SCO3231"
FT                   /protein_id="CAB38517.1"
FT   misc_feature    46308..47462
FT                   /note="Pfam match to entry PF00668 DUF4, Domain of unknown
FT                   function, score 290.10, E-value 2.7e-83"
FT                   /gene="SCO3231"
FT                   /gene_synonym="cdaPS2"
FT                   /gene_synonym="SCE63.02c"
FT   CDS_motif       46383..46502
FT                   /note="NRPS/PKS Motif: C2_DCL_024-062 (e-value: 7.2e-16,
FT                   bit-score: 50.4);"
FT   CDS_motif       46719..46784
FT                   /note="NRPS/PKS Motif: C3_DCL_135-156 (e-value: 3.4e-13,
FT                   bit-score: 41.9);"
FT   CDS_motif       46827..46850
FT                   /note="NRPS/PKS Motif: C4_LCL_164-176 (e-value: 17.0,
FT                   bit-score: -1.1);"
FT   CDS_motif       47094..47189
FT                   /note="NRPS/PKS Motif: C5_DCL_263-294 (e-value: 4.1e-22,
FT                   bit-score: 70.6);"
FT   CDS_motif       47238..47351
FT                   /note="NRPS/PKS Motif: C67_DCL_14fromHMM (e-value: 7.3e-19,
FT                   bit-score: 60.2);"
FT   misc_feature    47751..48881
FT                   /note="Pfam match to entry PF00501 AMP-binding, AMP-binding
FT                   enzyme, score 446.50, E-value 2.3e-130"
FT                   /gene="SCO3231"
FT                   /gene_synonym="cdaPS2"
FT                   /gene_synonym="SCE63.02c"
FT   CDS_motif       47874..47915
FT                   /note="NRPS/PKS Motif: NRPS-A_a2 (e-value: 0.00011,
FT                   bit-score: 15.5);"
FT   CDS_motif       48072..48131
FT                   /note="NRPS/PKS Motif: NRPS-A_a3 (e-value: 3e-10,
FT                   bit-score: 31.9);"
FT   misc_feature    48078..48113
FT                   /note="PS00455 Putative AMP-binding domain signature."
FT                   /gene="SCO3231"
FT                   /gene_synonym="cdaPS2"
FT                   /gene_synonym="SCE63.02c"
FT   CDS_motif       48465..48491
FT                   /note="NRPS/PKS Motif: NRPS-A_a5 (e-value: 0.19, bit-score:
FT                   5.1);"
FT   CDS_motif       48600..48686
FT                   /note="NRPS/PKS Motif: NRPS-A_a6 (e-value: 3.5e-15,
FT                   bit-score: 48.1);"
FT   CDS_motif       48774..48839
FT                   /note="NRPS/PKS Motif: NRPS-A_a8 (e-value: 1.6e-10,
FT                   bit-score: 33.1);"
FT   CDS_motif       49047..49073
FT                   /note="NRPS/PKS Motif: NRPS-A_a10 (e-value: 1.2, bit-score:
FT                   2.8);"
FT   misc_feature    49128..49322
FT                   /note="Pfam match to entry PF00550 pp-binding, Phosphopante
FT                   theine attachment site, score 78.00, E-value 5.9e-20"
FT                   /gene="SCO3231"
FT                   /gene_synonym="cdaPS2"
FT                   /gene_synonym="SCE63.02c"
FT   misc_feature    49197..49244
FT                   /note="PS00012 Phosphopantetheine attachment site."
FT                   /gene="SCO3231"
FT                   /gene_synonym="cdaPS2"
FT                   /gene_synonym="SCE63.02c"
FT   misc_feature    49365..50543
FT                   /note="Pfam match to entry PF00668 DUF4, Domain of unknown
FT                   function, score 332.60, E-value 4.3e-96"
FT                   /gene="SCO3231"
FT                   /gene_synonym="cdaPS2"
FT                   /gene_synonym="SCE63.02c"
FT   CDS_motif       49386..49418
FT                   /note="NRPS/PKS Motif: C1_LCL_004-017 (e-value: 0.007,
FT                   bit-score: 9.1);"
FT   CDS_motif       49437..49550
FT                   /note="NRPS/PKS Motif: C2_LCL_024-062 (e-value: 2.2e-18,
FT                   bit-score: 58.6);"
FT   CDS_motif       49755..49820
FT                   /note="NRPS/PKS Motif: C3_LCL_132-143 (e-value: 6.2e-09,
FT                   bit-score: 28.4);"
FT   CDS_motif       49869..49907
FT                   /note="NRPS/PKS Motif: C4_LCL_164-176 (e-value: 5.2e-05,
FT                   bit-score: 15.8);"
FT   CDS_motif       50175..50264
FT                   /note="NRPS/PKS Motif: C5_LCL_267-296 (e-value: 7.7e-15,
FT                   bit-score: 47.2);"
FT   CDS_motif       50313..50432
FT                   /note="NRPS/PKS Motif: C67_LCL_14fromHMM (e-value: 4.9e-22,
FT                   bit-score: 70.4);"
FT   misc_feature    50850..51998
FT                   /note="Pfam match to entry PF00501 AMP-binding, AMP-binding
FT                   enzyme, score 472.70, E-value 3e-138"
FT                   /gene="SCO3231"
FT                   /gene_synonym="cdaPS2"
FT                   /gene_synonym="SCE63.02c"
FT   CDS_motif       50973..51014
FT                   /note="NRPS/PKS Motif: NRPS-A_a2 (e-value: 8.4e-05,
FT                   bit-score: 15.9);"
FT   CDS_motif       51171..51227
FT                   /note="NRPS/PKS Motif: NRPS-A_a3 (e-value: 2.3e-08,
FT                   bit-score: 26.2);"
FT   CDS_motif       51594..51617
FT                   /note="NRPS/PKS Motif: NRPS-A_a5 (e-value: 0.21, bit-score:
FT                   5.1);"
FT   CDS_motif       51717..51806
FT                   /note="NRPS/PKS Motif: NRPS-A_a6 (e-value: 2.7e-14,
FT                   bit-score: 45.3);"
FT   CDS_motif       51891..51956
FT                   /note="NRPS/PKS Motif: NRPS-A_a8 (e-value: 1.2e-10,
FT                   bit-score: 33.4);"
FT   CDS_motif       52197..52220
FT                   /note="NRPS/PKS Motif: NRPS-A_a10 (e-value: 3.0, bit-score:
FT                   1.8);"
FT   misc_feature    52275..52469
FT                   /note="Pfam match to entry PF00550 pp-binding, Phosphopante
FT                   theine attachment site, score 88.00, E-value 1e-22"
FT                   /gene="SCO3231"
FT                   /gene_synonym="cdaPS2"
FT                   /gene_synonym="SCE63.02c"
FT   misc_feature    52344..52391
FT                   /note="PS00012 Phosphopantetheine attachment site."
FT                   /gene="SCO3231"
FT                   /gene_synonym="cdaPS2"
FT                   /gene_synonym="SCE63.02c"
FT   misc_feature    52512..53732
FT                   /note="Pfam match to entry PF00668 DUF4, Domain of unknown
FT                   function, score 326.10, E-value 3.9e-94"
FT                   /gene="SCO3231"
FT                   /gene_synonym="cdaPS2"
FT                   /gene_synonym="SCE63.02c"
FT   CDS_motif       52533..52565
FT                   /note="NRPS/PKS Motif: C1_LCL_004-017 (e-value: 0.022,
FT                   bit-score: 7.8);"
FT   CDS_motif       52584..52700
FT                   /note="NRPS/PKS Motif: C2_LCL_024-062 (e-value: 2.5e-18,
FT                   bit-score: 58.5);"
FT   CDS_motif       52902..52967
FT                   /note="NRPS/PKS Motif: C3_LCL_132-143 (e-value: 3e-10,
FT                   bit-score: 32.5);"
FT   CDS_motif       53016..53054
FT                   /note="NRPS/PKS Motif: C4_LCL_164-176 (e-value: 8.1e-06,
FT                   bit-score: 18.3);"
FT   CDS_motif       53322..53411
FT                   /note="NRPS/PKS Motif: C5_LCL_267-296 (e-value: 5.9e-15,
FT                   bit-score: 47.6);"
FT   CDS_motif       53460..53576
FT                   /note="NRPS/PKS Motif: C67_LCL_14fromHMM (e-value: 3e-22,
FT                   bit-score: 71.1);"
FT   misc_feature    54039..55265
FT                   /note="Pfam match to entry PF00501 AMP-binding, AMP-binding
FT                   enzyme, score 428.90, E-value 4.6e-125"
FT                   /gene="SCO3231"
FT                   /gene_synonym="cdaPS2"
FT                   /gene_synonym="SCE63.02c"
FT   CDS_motif       54162..54203
FT                   /note="NRPS/PKS Motif: NRPS-A_a2 (e-value: 0.0002,
FT                   bit-score: 14.7);"
FT   CDS_motif       54417..54476
FT                   /note="NRPS/PKS Motif: NRPS-A_a3 (e-value: 2.1e-10,
FT                   bit-score: 32.4);"
FT   misc_feature    54423..54458
FT                   /note="PS00455 Putative AMP-binding domain signature."
FT                   /gene="SCO3231"
FT                   /gene_synonym="cdaPS2"
FT                   /gene_synonym="SCE63.02c"
FT   CDS_motif       54840..54866
FT                   /note="NRPS/PKS Motif: NRPS-A_a5 (e-value: 0.72, bit-score:
FT                   3.5);"
FT   CDS_motif       54984..55073
FT                   /note="NRPS/PKS Motif: NRPS-A_a6 (e-value: 1.7e-15,
FT                   bit-score: 49.1);"
FT   CDS_motif       55158..55223
FT                   /note="NRPS/PKS Motif: NRPS-A_a8 (e-value: 5.8e-11,
FT                   bit-score: 34.4);"
FT   CDS_motif       55443..55469
FT                   /note="NRPS/PKS Motif: NRPS-A_a10 (e-value: 9.8, bit-score:
FT                   0.4);"
FT   misc_feature    55524..55715
FT                   /note="Pfam match to entry PF00550 pp-binding, Phosphopante
FT                   theine attachment site, score 71.90, E-value 2.9e-18"
FT                   /gene="SCO3231"
FT                   /gene_synonym="cdaPS2"
FT                   /gene_synonym="SCE63.02c"
FT   misc_feature    55593..55640
FT                   /note="PS00012 Phosphopantetheine attachment site"
FT                   /gene="SCO3231"
FT                   /gene_synonym="cdaPS2"
FT                   /gene_synonym="SCE63.02c"
FT   misc_feature    55800..57047
FT                   /note="Pfam match to entry PF00668 DUF4, Domain of unknown
FT                   function, score 87.50, E-value 2.7e-22"
FT                   /gene="SCO3231"
FT                   /gene_synonym="cdaPS2"
FT                   /gene_synonym="SCE63.02c"
FT   CDS_motif       55869..55973
FT                   /note="NRPS/PKS Motif: C2_LCL_024-062 (e-value: 7e-07,
FT                   bit-score: 21.7);"
FT   CDS_motif       56193..56258
FT                   /note="NRPS/PKS Motif: NRPS-E2 (e-value: 1.9e-09,
FT                   bit-score: 29.8);"
FT   CDS_motif       56664..56711
FT                   /note="NRPS/PKS Motif: NRPS-E5 (e-value: 1.3e-06,
FT                   bit-score: 20.7);"
FT   CDS_motif       56790..56852
FT                   /note="NRPS/PKS Motif: NRPS-E6 (e-value: 2.4e-09,
FT                   bit-score: 29.4);"
FT   misc_feature    57287..58267
FT                   /note="Pfam match to entry PF00668 DUF4, Domain of unknown
FT                   function, score 187.70, E-value 1.9e-52."
FT                   /gene="SCO3232"
FT                   /gene_synonym="cdaPS3"
FT                   /gene_synonym="SCE29.01"
FT                   /gene_synonym="SCE63.01"
FT   gene            57287..64540
FT                   /gene="SCO3232"
FT                   /gene_synonym="cdaPS3"
FT                   /gene_synonym="SCE29.01"
FT                   /gene_synonym="SCE63.01"
FT   CDS             57287..64540
FT                   /product="CDA peptide synthetase III"
FT                   /codon_start=1
FT                   /gene_synonym="cdaPS3"
FT                   /gene_synonym="SCE29.01"
FT                   /gene_synonym="SCE63.01"
FT                   /transl_table=11
FT                   /note="SCE63.01, partial CDS, cdaPS3, CDA peptide
FT                   synthetase III, len: >332 aa; Constitutes the N-terminus of
FT                   cdaPS3, CDA peptide synthetase III, part of the
FT                   calcium-dependent antibiotic (CDA) biosynthetic cluster
FT                   from Streptomyces coelicolor. CDA is a peptide antibiotic
FT                   which is synthesised non-ribosomally by a putative
FT                   multifunctional peptide synthetase enzyme. This partial CDS
FT                   encodes the N-terminus of a subunit of this enzyme
FT                   suspected to be responsible for the addition of 2 amino
FT                   acids to the peptide antibiotic. This ORF overlaps the
FT                   upstream (cdaPSII) by one base indicating possible
FT                   translational coupling. Contains Pfam match to entry
FT                   PF00668 DUF4, Domain of unknown function.; SCE29.01,
FT                   partial CDS, cdaPS3, CDA peptide synthetase III, len:
FT                   >332aa; Constitutes the the majority of cdaPS3, CDA peptide
FT                   synthetase III, part of the calcium-dependent antibiotic
FT                   (CDA) biosynthetic cluster from Streptomyces coelicolor.
FT                   CDA is a peptide antibiotic which is synthesised
FT                   non-ribosomally by a putative multifunctional peptide
FT                   synthetase enzyme. This partial CDS encodes a subunit of
FT                   this enzyme suspected to be responsible for the addition of
FT                   2 amino acids to the peptide antibiotic. This ORF overlaps
FT                   the upstream (cdaPSII) by one base indicating possible
FT                   translational coupling. Contains two Pfam matches to entry
FT                   PF00501 AMP-binding, AMP-binding enzyme, a Pfam match to
FT                   entry PF00668 DUF4, Domain of unknown function, a Pfam
FT                   match to entry PF00975 Thioesterase, Thioesterase domain
FT                   and two Pfam matches to entry PF00550 pp-binding,
FT                   Phosphopantetheine attachment site. Each PF00501 contains a
FT                   Prosite match PS00455 Putative AMP-binding domain
FT                   signature. Each PF00550 contains a Prosite match PS00012
FT                   Phosphopantetheine attachment site."
FT                   /note="smCOG:
FT                   SMCOG1127:condensation_domain-containing_protein (Score:
FT                   346.1; E-value: 6.1e-105);"
FT                   /db_xref="GI:24426512"
FT                   /db_xref="GOA:Q8CJX2"
FT                   /db_xref="HSSP:1AMU"
FT                   /db_xref="InterPro:IPR000873"
FT                   /db_xref="InterPro:IPR001031"
FT                   /db_xref="InterPro:IPR001242"
FT                   /db_xref="InterPro:IPR006162"
FT                   /db_xref="InterPro:IPR006163"
FT                   /db_xref="InterPro:IPR009081"
FT                   /db_xref="InterPro:IPR010071"
FT                   /db_xref="InterPro:IPR020806"
FT                   /db_xref="InterPro:IPR020845"
FT                   /db_xref="UniProtKB/TrEMBL:Q8CJX2"
FT                   /sec_met="Type: nrps"
FT                   /sec_met="Domains detected: Condensation (E-value: 6.4e-68,
FT                   bitscore: 220.3, seeds: 42); Condensation (E-value:
FT                   2.8e-75, bitscore: 244.5, seeds: 42); AMP-binding (E-value:
FT                   1.8e-104, bitscore: 340.9, seeds: 400); AMP-binding
FT                   (E-value: 7.9e-112, bitscore: 365.1, seeds: 400);
FT                   PP-binding (E-value: 2.3e-15, bitscore: 48.3, seeds: 164);
FT                   PP-binding (E-value: 1.9e-16, bitscore: 51.8, seeds: 164)"
FT                   /sec_met="Kind: biosynthetic"
FT                   /sec_met="NRPS/PKS subtype: NRPS"
FT                   /sec_met="NRPS/PKS Domain: NRPS-COM_Nterm (2-28). E-value:
FT                   1.7e-11. Score: 34.5;"
FT                   /sec_met="NRPS/PKS Domain: Condensation_DCL (6-302).
FT                   E-value: 3e-116. Score: 379.0;"
FT                   /sec_met="NRPS/PKS Domain: AMP-binding (488-898). E-value:
FT                   1.6e-104. Score: 340.9;"
FT                   /sec_met="NRPS/PKS Domain: PCP (980-1048). E-value:
FT                   5.7e-27. Score: 85.0;"
FT                   /sec_met="NRPS/PKS Domain: Condensation_LCL (1062-1363).
FT                   E-value: 3.3e-120. Score: 391.8;"
FT                   /sec_met="NRPS/PKS Domain: AMP-binding (1562-1960).
FT                   E-value: 7.3e-112. Score: 365.1;"
FT                   /sec_met="NRPS/PKS Domain: PCP (2042-2110). E-value:
FT                   1.1e-29. Score: 93.8;"
FT                   /sec_met="NRPS/PKS Domain: Thioesterase (2129-2369).
FT                   E-value: 2.3e-40. Score: 130.7;"
FT                   /translation="MAKSGLEDILPLSPLQEGMLFHNLFDEEELDAYNVQVFIDLEGGT
FT                   DPERLRRAGQALLERHANLRAAFRHEGLKRPVQLIPRRVVLPWGEEDLSGVAEPEREAA
FT                   AERVAERDRWTRFDLSRPPLIRFTLVRLGPARHRLLLTLHHILADGWSMPILLRELMTL
FT                   YTVHGDGTALPRVRPYRDYLGWLGGRDRDAARQAWTEAFAGLDAPSIVAPGRGALTAAP
FT                   ERIDFSEDEAASAALTRFARSNGLTVNTVIQGCWGLVLSHLTGRDDVVFGVTVSGRPPE
FT                   LPGIDTMVGLFMNTLPLRVRLRPAETLTGFLRRLQGEQARLIDHQWVGLAEIQRWAGSG
FT                   ELFDTAMVFENYPLNSSRGRPPGAAPDADLPTVLGVRSKDQMHYPLGLLALPRETLRFS
FT                   LGYLPQVFDPARVEAVIAAFRRALRTVLDAPDTRVGAVALLDPEVRGTVLEKWSGSDDV
FT                   RPAERFTDLFEEQVARTPGKTALIAPDGRLTYAELDAAANRLARRLVELGVGPERHVAV
FT                   AVGRRTELVVGMLAVLKAGGAYVPVDPEYPPDRIRHMIQDADPALVLTTSDVDDRIGEE
FT                   CCGPLTFVMDDPNTGTSLGRHSGTALTDADRAAPLLPGHPAYVIYTSGTTGRPKGVVVE
FT                   HRALSAFVRHCRSSQAPDISGLSVMQASASFDQSVGSLHAPLISGGCVRLTDLRALAET
FT                   AGSEPGFHRATFMKGTPSHLALLATMPPEVAPSGTLTLGGEELRGEILAPWREAAGDVT
FT                   VVNVYGPTEATGHCLEHWIAPDRTVEPGPVPIGTPHEGVRVYVLDSALRPVAPGLDGEV
FT                   YLAGVQLARGYLGRGGLTAERFTADPFGAPGSRMYRTGDVAHWNEAGELVFAGRADRQV
FT                   KLRGYRIELGEIEAAVAGGPGVRQAAVVLREDRPGDQRLVAYVVPDPGHWDEAAARARL
FT                   ALSLPDFMMPSAFVALDALPLSPNGKLDRAALPAPTYTGRTAGRAPRTPAEEILCDLYA
FT                   EVLSLPGVTVDDDFFDLGGHSLLATRLVSRVRTTLGAELSIRQFFEAPTPAALAVVLAG
FT                   AGRARAALTARPRPERLPLSYAQQRLWFLHLLEGPSPTYNIPTVLRLSGPLRPDALRAA
FT                   LLDVVGRHESLRTTFTEDERGARQVVHPADGVRPVFETAESTEADYEADLARAARHAFD
FT                   LGAEIPVRARLLRLSEREHVLLLLVHHIASDAWSRGPLAQDLTAAYTARCAGDAPAWQP
FT                   LPVQYADYALWQQEILGDDTDPDTLAGRQLAYWKQQLAGLPERLDLPTDRPRPATADHT
FT                   GDRVEFALPADLHTRLTELARATDTTLYMVLQAALATLLTRHGAGEDIPIGTPVAGRTD
FT                   DATDHLVGFFVNTLVLRTDTSGNPTFRDLLTRVRDTDLTAYTHQDLPFERLVEALNPTR
FT                   SLTHHPLFQVVLSLRSTAPRRADGEGAPALPGGLRVSGTGGAAATAAKVDLGFSVTERR
FT                   AADHTPDGVAGVLDFRTDLFDRGTAQGLVDRLVRVLADAAAHPDRPLSRIDVLGPRERH
FT                   RVVEEWNATAKGLAPATLPELFERHVRERPGAEAVVAGDTSLSYAELNARANRLARLLV
FT                   ARGAGPERLVALALPRSAELPVAVLAVAKAGAAYLPLDPAHPAERIAGTLDDAAPVALL
FT                   TTAAVAAGLPDTDVPRLLLDEEPAAGGGEDAADLTDADRLAPLLPGHPAYVIYTSGTTG
FT                   RPKGVTVTHSGLPALLDIFTSQLDVVPGSRVLHHLSPAFDGGFWELAMGLLTGAALVVV
FT                   EPGTVPGPALAALAVRHRVTHAAITPAVLQLIPEGALPAGTTLVVAAETCPPELVARWS
FT                   AGRLMRNSYGPTETTVCATMSAPLAGAAVPPIGRPIADTAGYVLDDALQPVPPGVPGEL
FT                   YVRGPGLARGYLGRPSLTAGRFVACPFGPAGGVMYRTGDLVRHRADGDLEYLGRTDTQV
FT                   KLRGMRVEPAEIEAVTAGLPGVAQAAVLVREDTPGDRRLVGYVVPDAGASVDPGALRQA
FT                   LRGSLPEYMVPAALVVLDALPLTTNGKLDHRALPAPEYRTVEGRSPRTPREEALCRLFA
FT                   EVLGLELVGLDDGFFDLGGHSLLAIRLVERVRAELGEELGVRDLFAAPTVADLAVRLAA
FT                   RGGREPMERLLPLRAAGTARPVFCVHPGSGMSWCYSGLVRHLPPGIPVYGLQAAGLDGD
FT                   GPLPATLQEMAAEYADLVRQTQPEGPYRLLGWSLGGNVAFAMARELRARGQEVELLAFL
FT                   DAYPRRAGAGPEAPLAEVFAHNLRDAGFDVAEEELTGGRFPTARYRAFLNAAGDPMGRL
FT                   DEAELAAVLEVFMNNAALMRGHTPGTYDGDVLVLAAERADGDKLARRGAESWRPHVRGR
FT                   IERVGVDADHLGLVQSDAALAVIGRALAGRLDPATGHAASAAVPETEGVTAMNPSPEPA
FT                   PSPESLDSTEVA"
FT                   /gene="SCO3232"
FT                   /protein_id="CAD55498.1"
FT   CDS_motif       57317..57352
FT                   /note="NRPS/PKS Motif: C1_dual_004-017 (e-value: 0.00013,
FT                   bit-score: 14.7);"
FT   CDS_motif       57377..57496
FT                   /note="NRPS/PKS Motif: C2_DCL_024-062 (e-value: 1.4e-16,
FT                   bit-score: 52.8);"
FT   CDS_motif       57713..57778
FT                   /note="NRPS/PKS Motif: C3_DCL_135-156 (e-value: 8.5e-13,
FT                   bit-score: 40.6);"
FT   CDS_motif       58088..58183
FT                   /note="NRPS/PKS Motif: C5_DCL_263-294 (e-value: 1.1e-19,
FT                   bit-score: 62.9);"
FT   misc_feature    complement(58185..58285)
FT                   /note="Overlap with Streptomyces coelicolor cosmid StE63."
FT   CDS_motif       58232..58345
FT                   /note="NRPS/PKS Motif: C67_DCL_14fromHMM (e-value: 1.8e-20,
FT                   bit-score: 65.4);"
FT   misc_feature    58751..59978
FT                   /note="Pfam match to entry PF00501 AMP-binding, AMP-binding
FT                   enzyme, score 385.20, E-value 6.6e-112"
FT                   /gene="SCO3232"
FT                   /gene_synonym="cdaPS3"
FT                   /gene_synonym="SCE29.01"
FT                   /gene_synonym="SCE63.01"
FT   CDS_motif       58874..58915
FT                   /note="NRPS/PKS Motif: NRPS-A_a2 (e-value: 1.3e-05,
FT                   bit-score: 18.3);"
FT   CDS_motif       59135..59194
FT                   /note="NRPS/PKS Motif: NRPS-A_a3 (e-value: 1e-10,
FT                   bit-score: 33.3);"
FT   misc_feature    59141..59176
FT                   /note="PS00455 Putative AMP-binding domain signature."
FT                   /gene="SCO3232"
FT                   /gene_synonym="cdaPS3"
FT                   /gene_synonym="SCE29.01"
FT                   /gene_synonym="SCE63.01"
FT   CDS_motif       59558..59581
FT                   /note="NRPS/PKS Motif: NRPS-A_a5 (e-value: 0.38, bit-score:
FT                   4.3);"
FT   CDS_motif       59702..59788
FT                   /note="NRPS/PKS Motif: NRPS-A_a6 (e-value: 3.6e-11,
FT                   bit-score: 35.3);"
FT   CDS_motif       59873..59938
FT                   /note="NRPS/PKS Motif: NRPS-A_a8 (e-value: 2.3e-11,
FT                   bit-score: 35.6);"
FT   misc_feature    60230..60422
FT                   /note="Pfam match to entry PF00550 pp-binding,
FT                   Phosphopantetheine attachment site, score 78.40, E-value
FT                   4.6e-20"
FT                   /gene="SCO3232"
FT                   /gene_synonym="cdaPS3"
FT                   /gene_synonym="SCE29.01"
FT                   /gene_synonym="SCE63.01"
FT   misc_feature    60299..60346
FT                   /note="PS00012 Phosphopantetheine attachment site."
FT                   /gene="SCO3232"
FT                   /gene_synonym="cdaPS3"
FT                   /gene_synonym="SCE29.01"
FT                   /gene_synonym="SCE63.01"
FT   misc_feature    60467..61664
FT                   /note="Pfam match to entry PF00668 DUF4, Domain of unknown
FT                   function, score 335.30, E-value 6.9e-97"
FT                   /gene="SCO3232"
FT                   /gene_synonym="cdaPS3"
FT                   /gene_synonym="SCE29.01"
FT                   /gene_synonym="SCE63.01"
FT   CDS_motif       60488..60520
FT                   /note="NRPS/PKS Motif: C1_LCL_004-017 (e-value: 0.0042,
FT                   bit-score: 9.7);"
FT   CDS_motif       60539..60652
FT                   /note="NRPS/PKS Motif: C2_LCL_024-062 (e-value: 5e-18,
FT                   bit-score: 57.5);"
FT   CDS_motif       60857..60922
FT                   /note="NRPS/PKS Motif: C3_LCL_132-143 (e-value: 4e-09,
FT                   bit-score: 29.0);"
FT   CDS_motif       60971..61009
FT                   /note="NRPS/PKS Motif: C4_LCL_164-176 (e-value: 3.3e-05,
FT                   bit-score: 16.4);"
FT   CDS_motif       61277..61366
FT                   /note="NRPS/PKS Motif: C5_LCL_267-296 (e-value: 7.1e-15,
FT                   bit-score: 47.3);"
FT   CDS_motif       61415..61534
FT                   /note="NRPS/PKS Motif: C67_LCL_14fromHMM (e-value: 1.2e-21,
FT                   bit-score: 69.2);"
FT   misc_feature    61973..63164
FT                   /note="Pfam match to entry PF00501 AMP-binding, AMP-binding
FT                   enzyme, score 448.70, E-value 5.2e-131"
FT                   /gene="SCO3232"
FT                   /gene_synonym="cdaPS3"
FT                   /gene_synonym="SCE29.01"
FT                   /gene_synonym="SCE63.01"
FT   CDS_motif       62096..62137
FT                   /note="NRPS/PKS Motif: NRPS-A_a2 (e-value: 0.00011,
FT                   bit-score: 15.5);"
FT   CDS_motif       62345..62404
FT                   /note="NRPS/PKS Motif: NRPS-A_a3 (e-value: 9.7e-10,
FT                   bit-score: 30.4);"
FT   misc_feature    62351..62386
FT                   /note="PS00455 Putative AMP-binding domain signature."
FT                   /gene="SCO3232"
FT                   /gene_synonym="cdaPS3"
FT                   /gene_synonym="SCE29.01"
FT                   /gene_synonym="SCE63.01"
FT   CDS_motif       62753..62782
FT                   /note="NRPS/PKS Motif: NRPS-A_a5 (e-value: 0.011,
FT                   bit-score: 8.6);"
FT   CDS_motif       62885..62974
FT                   /note="NRPS/PKS Motif: NRPS-A_a6 (e-value: 1e-15,
FT                   bit-score: 49.8);"
FT   CDS_motif       63059..63124
FT                   /note="NRPS/PKS Motif: NRPS-A_a8 (e-value: 3.1e-10,
FT                   bit-score: 32.1);"
FT   misc_feature    63416..63608
FT                   /note="Pfam match to entry PF00550 pp-binding,
FT                   Phosphopantetheine attachment site, score 76.90, E-value
FT                   1.2e-19"
FT                   /gene="SCO3232"
FT                   /gene_synonym="cdaPS3"
FT                   /gene_synonym="SCE29.01"
FT                   /gene_synonym="SCE63.01"
FT   misc_feature    63485..63532
FT                   /note="PS00012 Phosphopantetheine attachment site."
FT                   /gene="SCO3232"
FT                   /gene_synonym="cdaPS3"
FT                   /gene_synonym="SCE29.01"
FT                   /gene_synonym="SCE63.01"
FT   misc_feature    63674..64403
FT                   /note="Pfam match to entry PF00975 Thioesterase,
FT                   Thioesterase domain, score 139.00, E-value 8.5e-38"
FT                   /gene="SCO3232"
FT                   /gene_synonym="cdaPS3"
FT                   /gene_synonym="SCE29.01"
FT                   /gene_synonym="SCE63.01"
FT   CDS_motif       63677..63706
FT                   /note="NRPS/PKS Motif: NRPS-beforete1 (e-value: 0.004,
FT                   bit-score: 10.2);"
FT   CDS_motif       63857..63931
FT                   /note="NRPS/PKS Motif: NRPS-te1 (e-value: 1.1e-15,
FT                   bit-score: 49.8);"
FT   gene            64544..65362
FT                   /gene="SCO3233"
FT                   /gene_synonym="SCE29.0"
FT   CDS             64544..65362
FT                   /product="putative hydrolase"
FT                   /codon_start=1
FT                   /gene_synonym="SCE29.0"
FT                   /transl_table=11
FT                   /note="SCE29.02, probable hydrolase, len: 272 aa; similar
FT                   to many e.g. TR:O52809 (EMBL:AJ223998) from the vancomycin
FT                   biosynthesis cluster of Amycolatopsis orientalis (276 aa)
FT                   fasta scores; opt: 892, z-score: 1028.9, E(): 0, (50.9%
FT                   identity in 271 aa overlap) and TR:O67982 (EMBL:AF003947)
FT                   PcaL; single polypeptide combining 3-oxoadipate
FT                   enol-lactone hydrolyzing and 4-carboxymuconolactone
FT                   decarboxylating activityfrom Rhodococcus opacus (400 aa)
FT                   fasta scores; opt: 288, z-score: 335.4, E(): 2.3e-11,
FT                   (32.0% identity in 256 aa overlap). Contains Pfam match to
FT                   entry PF00561 abhydrolase, alpha/beta hydrolase fold, score
FT                   77.80, E-value 2.2e-19."
FT                   /note="smCOG: SMCOG1036:alpha/beta_hydrolase_fold_protein
FT                   (Score: 162.1; E-value: 3.7e-49);"
FT                   /db_xref="GI:4490980"
FT                   /db_xref="GOA:Q9Z4Z8"
FT                   /db_xref="InterPro:IPR000073"
FT                   /db_xref="InterPro:IPR000639"
FT                   /db_xref="UniProtKB/TrEMBL:Q9Z4Z8"
FT                   /translation="MPVLTVNGIRINYYDDAPPAGAQNAPAVLLVMGSGGSGRAWHLHQ
FT                   VPALVAAGFRVISFDNRGIAPSEECPGGFGIDDLVADTAALVEELRLGPCRVAGISMGA
FT                   HIAQELALSRPDLVDRLVLMATRARPDALREALCRAEMELYDQGIRLPAAYEAVVQAMQ
FT                   NLSPRTLDNDVQARDWLDVLELTRRSGAGYRAQLGVRVDGDRREAYRGIRAATRVVAFQ
FT                   DDLIAPPHLGREVADAIPGAEYELVPDCGHYGYLESPDAVNKSLVEFLRR"
FT                   /gene="SCO3233"
FT                   /protein_id="CAB38877.1"
FT   misc_feature    64703..65353
FT                   /note="Pfam match to entry PF00561 abhydrolase, alpha/beta
FT                   hydrolase fold, score 77.80, E-value 2.2e-19."
FT                   /gene="SCO3233"
FT                   /gene_synonym="SCE29.0"
FT   gene            65374..66276
FT                   /gene="SCO3234"
FT                   /gene_synonym="SCE29.03"
FT   CDS             65374..66276
FT                   /product="putative phosphotransferase"
FT                   /codon_start=1
FT                   /gene_synonym="SCE29.03"
FT                   /transl_table=11
FT                   /note="SCE29.03, possible phosphotransferase, len: 300 aa;
FT                   weak similarity to TR:P72441 (EMBL:U70376) spectinomycin
FT                   phosphotransferase from spectinomycin producer Streptomyces
FT                   flavopersicus (330 aa) fasta scores; opt: 145, z-score:
FT                   177.0, E(): 0.015, (25.3% identity in 261 aa overlap)."
FT                   /db_xref="GI:4490981"
FT                   /db_xref="GOA:Q9Z4Z7"
FT                   /db_xref="InterPro:IPR002575"
FT                   /db_xref="InterPro:IPR011009"
FT                   /db_xref="UniProtKB/Swiss-Prot:Q9Z4Z7"
FT                   /translation="MKTESDVQTGAPTAADGALIALAREVCPGFAPGEVVYRSRTSLVV
FT                   GGELDGVEALAKVRTPDWRRQCLREIDTYDLFDAVPPPVPVPRRFASDRERAVLVMERL
FT                   TGEVLAPDRFPVTPVSREDLAGVLEAVERLRHWRPAAAGAWAVDYRGMLEGVHAQGVFD
FT                   DGHWADLLRLLELSGAPREFGHGDLVLANVVRSRGRQVLIDWASSALYLPGLDLAQLWM
FT                   LLGDVPGARARIEVEVADRADDRDGMMPFLVNLTLLLYRERRAHRRFTDDASRARAVGL
FT                   DAAWELTRHRVRQCLATAG"
FT                   /gene="SCO3234"
FT                   /protein_id="CAB38878.1"
FT   stem_loop       66281..66343
FT                   /note="Possible stem loop with 8 base loop."
FT   gene            complement(66352..68199)
FT                   /gene="SCO3235"
FT                   /gene_synonym="SCE29.04c"
FT   CDS             complement(66352..68199)
FT                   /product="putative ABC transporter"
FT                   /codon_start=1
FT                   /gene_synonym="SCE29.04c"
FT                   /transl_table=11
FT                   /note="SCE29.04c, probable ABC transporter, len: 615aa;
FT                   similar to many eg. TR:D1035364 (EMBL:AB019513) ABC
FT                   transporter from Streptomyces coelicolor fasta scores; opt:
FT                   783, z-score: 794.3, E(): 0, (42.8% identity in 596 aa
FT                   overlap). C-terminal half contains Pfam match to entry
FT                   PF00005 ABC_tran, ABC transporter (score 184.50, E-value
FT                   1.7e-51) which itself contains Prosite matches to PS00211
FT                   ABC transporters family signature and PS00017
FT                   ATP/GTP-binding site motif A (P-loop). N-terminal half
FT                   contains Pfam match to entry PF00664 ABC_membrane, ABC
FT                   transporter transmembrane region., score 129.80, E-value
FT                   4.9e-35. Contains probable transmembrane hydrophobic
FT                   regions."
FT                   /note="smCOG: SMCOG1288:ABC_transporter_related_protein
FT                   (Score: 339.0; E-value: 8.6e-103);"
FT                   /db_xref="GI:4490982"
FT                   /db_xref="GOA:Q9Z4Z6"
FT                   /db_xref="HSSP:1MV5"
FT                   /db_xref="InterPro:IPR001140"
FT                   /db_xref="InterPro:IPR003439"
FT                   /db_xref="InterPro:IPR003593"
FT                   /db_xref="InterPro:IPR011527"
FT                   /db_xref="InterPro:IPR017871"
FT                   /db_xref="InterPro:IPR017940"
FT                   /db_xref="UniProtKB/TrEMBL:Q9Z4Z6"
FT                   /translation="MTSTQTRERPPARKTGAKNAPEPGPPAPPVRKVGLRSLFPYLQGY
FT                   WPTLGIVAVLSLVVTLLTLSQPVLTRDVLADIEADRPVGRLVALLIGVLVVVAVLGGVR
FT                   DYLLQRAAEGLVLTARRRLVARLLRLPITEYDQRRTGDMLSRVGADTTMLRAVVTSGLF
FT                   DTVTNVVMVGGSALMMCLIDPTLFAATALGLGLGVLAVVGLSRRVRGASRDAQDRIGEM
FT                   TSAVERAISAVRTIRASGAEEREGKAVDGYAQQAYHAGMRIARLQAMINPITSTTIQVA
FT                   FLVVLGLGGARVASGAIQVGDMVAFVLFLFMLWFPLGRALTAYSRLQSGLGALQRIEEM
FT                   VDLPQETDAVAGPLTVRERTRPGTEPADAEPRPPAIEFEGVSFGYGDGETVLRDVSLAV
FT                   PRGTRTALVGPSGAGKSTLLSLVERFYDVTSGTVRVGGTDVRDLPRRELRGRLGYVEQS
FT                   APVLAGTVRDNLSLAAPDATDDDMREVLRSVNLMGVIERAPQGLDTEVGEGGVLLSGGE
FT                   RQRLALARTFLAAPPIMLLDEATSNLDARNEALMREAIGTVTADRTLLVVAHRLSTVVD
FT                   SDQIVVLEHGRVVAAGRHEELTGTSPLYRELASHQLLIQ"
FT                   /gene="SCO3235"
FT                   /protein_id="CAB38879.1"
FT   misc_feature    complement(66442..66996)
FT                   /note="Pfam match to entry PF00005 ABC_tran, ABC
FT                   transporter, score 184.50, E-value 1.7e-51"
FT                   /gene="SCO3235"
FT                   /gene_synonym="SCE29.04c"
FT   misc_feature    complement(66619..66663)
FT                   /note="PS00211 ABC transporters family signature."
FT                   /gene="SCO3235"
FT                   /gene_synonym="SCE29.04c"
FT   misc_feature    complement(66952..66975)
FT                   /note="PS00017 ATP/GTP-binding site motif A (P-loop)."
FT                   /gene="SCO3235"
FT                   /gene_synonym="SCE29.04c"
FT   misc_feature    complement(67249..68055)
FT                   /note="Pfam match to entry PF00664 ABC_membrane, ABC
FT                   transporter transmembrane region., score 129.80, E-value
FT                   4.9e-35."
FT                   /gene="SCO3235"
FT                   /gene_synonym="SCE29.04c"
FT   gene            complement(68239..69240)
FT                   /gene="SCO3236"
FT                   /gene_synonym="SCE29.05c"
FT   CDS             complement(68239..69240)
FT                   /product="putative oxygenase"
FT                   /codon_start=1
FT                   /gene_synonym="SCE29.05c"
FT                   /transl_table=11
FT                   /note="SCE29.05c, possible oxygenase, len: 333 aa; similar
FT                   to TR:Q05581 (EMBL:L06213) clavaminate synthase I, an
FT                   alpha-ketoglutarate-dependent oxygenase central to the
FT                   biosynthesis of clavulanic acid, a potent inhibitor of
FT                   beta-lactamases (324 aa) fasta scores; opt: 498, z-score:
FT                   571.8, E(): 1.5e-24, (34.3% identity in 283 aa overlap)."
FT                   /note="smCOG: SMCOG1046:Dioxygenase_TauD/TfdA (Score: 24.4;
FT                   E-value: 7.68e-06);"
FT                   /db_xref="GI:4490983"
FT                   /db_xref="GOA:Q9Z4Z5"
FT                   /db_xref="InterPro:IPR003819"
FT                   /db_xref="InterPro:IPR014503"
FT                   /db_xref="PDB:2OG5"
FT                   /db_xref="PDB:2OG6"
FT                   /db_xref="PDB:2OG7"
FT                   /db_xref="UniProtKB/Swiss-Prot:Q9Z4Z5"
FT                   /translation="MAANAAGPASRYDVTLDQSDAELVEEIAWKLATQATGRPDDAEWV
FT                   EAARNAWHAWPATLRRDLAGFRRDSGPDGAIVLRGLPVDSMGLPPTPRVNGSVQREASL
FT                   GAAVLLMTACGLGDPGAFLPEKNGALVQDVVPVPGMEEFQGNAGSTLLTFHNENAFHEH
FT                   RPDFVMLLCLRADPTGRAGLRTACVRRVLPLLSDSTVDALWAPEFRTAPPPSFQLSGPE
FT                   EAPAPVLLGDRSDPDLRVDLAATEPVTERAAEALRELQAHFDATAVTHRLLPGELAIVD
FT                   NRVTVHGRTEFTPRYDGTDRWLQRTFVLTDLRRSRAMRPADGYVLGAAPQPA"
FT                   /gene="SCO3236"
FT                   /protein_id="CAB38880.1"
FT   gene            complement(69298..70686)
FT                   /gene="SCO3237"
FT                   /gene_synonym="SCE29.06c"
FT   CDS             complement(69298..70686)
FT                   /product="conserved hypothetical protein"
FT                   /codon_start=1
FT                   /gene_synonym="SCE29.06c"
FT                   /transl_table=11
FT                   /note="SCE29.06c, unknown, len: 462 aa; similar to
FT                   TR:O69954 (EMBL:AL023862) hypothetical protein from
FT                   Streptomyces coelicolor (465 aa) fasta scores; opt: 2210,
FT                   z-score: 2646.8, E(): 0, (70.8% identity in 452 aa
FT                   overlap)."
FT                   /db_xref="GI:4490984"
FT                   /db_xref="GOA:Q9Z4Z4"
FT                   /db_xref="InterPro:IPR002591"
FT                   /db_xref="InterPro:IPR017849"
FT                   /db_xref="InterPro:IPR017850"
FT                   /db_xref="UniProtKB/TrEMBL:Q9Z4Z4"
FT                   /translation="MLDVVGLTPRLLAHMPRLSALRDAGTGARLDTVLPAVTCSVQSTL
FT                   LTGRPPAEHGVVGNGWYFRDLGEVLLWRQHNRLVGGEKVWQAARALHPGYTVANVCWWY
FT                   AMGADVDWTVTPRPVYYADGRKEPDCYTHPASLHDELTGRLGPFPLFHYWGPTADLASS
FT                   RWIVDAARHLHRAHKPDLNLVYVPHLDYDLQRFGPDSRRARRAAAELDRTLAPLLDEAR
FT                   RDGVTVVVLSEYGITPVSRPVDINRALRRAGLLAVHTQDGMEYLDPWTSRAFAVADHQV
FT                   AHVYVRDAADLPRVEELLHGLDGVAEVLGEAGKKEHGLDHERAGELVAVARPEAWFTYY
FT                   YWLDDARAPDFARTVEIHRKPGYDPAELGFDHHAPAKARLRAAAALARKKLGLRYTMNV
FT                   VPLDGSRVRGSHGRLPGRPEDAPVLLVSDPDAPLGELVAATEVKELLLSLAGISPHAHS
FT                   IRGR"
FT                   /gene="SCO3237"
FT                   /protein_id="CAB38881.1"
FT   gene            complement(70698..71858)
FT                   /gene="SCO3238"
FT                   /gene_synonym="SCE29.07c"
FT   CDS             complement(70698..71858)
FT                   /product="hypothetical protein"
FT                   /codon_start=1
FT                   /gene_synonym="SCE29.07c"
FT                   /transl_table=11
FT                   /note="SCE29.07c, unknown, len: 386 aa; similar to
FT                   TR:O69953 (EMBL:AL023862) hypothetical protein from
FT                   Streptomyces coelicolor (391 aa) fasta scores; opt: 1396,
FT                   z-score: 1559.7, E(): 0, (58.6% identity in 389 aa
FT                   overlap). Contains PS00730 AP endonucleases family 2
FT                   signature 2."
FT                   /db_xref="GI:4490985"
FT                   /db_xref="GOA:Q9Z4Z3"
FT                   /db_xref="InterPro:IPR012307"
FT                   /db_xref="InterPro:IPR013022"
FT                   /db_xref="InterPro:IPR018246"
FT                   /db_xref="UniProtKB/TrEMBL:Q9Z4Z3"
FT                   /translation="MRLRHRDGTTVHLAYCTNVHAAEDLDGVLAQLARYGEPVRERLGA
FT                   DRIGLGLWLAAPVVTALAADRSALDLLRKELDLRGIEVVTLNAFPYAGFHAPTVKKAVY
FT                   RPDWTERPRLDHTLACARVLAELLPPDAARGSVSTLPLAWRTPWTPRRDDLARRHLDLL
FT                   SQGLAALNADTGRTVRVGFEPEPGCLIETTGQAVARLAGADPERLGVCVDTCHLAVAFE
FT                   EPGPALTRLAAALPVVKTQASCAVHADRPADPAARAALAAFAERRFLHQTRQAAPGGPS
FT                   AVDDLPEALGGALNGDAAWRIHYHVPVQRDLPPPLRSTRPELVAALTTLLGGPTALTDH
FT                   VEVETYTWPVLPGAPDGGGLVDGIAGELAWTRSALTALGLTEESTP"
FT                   /gene="SCO3238"
FT                   /protein_id="CAB38882.1"
FT   misc_feature    complement(71211..71234)
FT                   /note="PS00730 AP endonucleases family 2 signature 2."
FT                   /gene="SCO3238"
FT                   /gene_synonym="SCE29.07c"
FT   gene            complement(71865..72734)
FT                   /gene="SCO3239"
FT                   /gene_synonym="SCE29.08c"
FT   CDS             complement(71865..72734)
FT                   /product="conserved hypothetical protein"
FT                   /codon_start=1
FT                   /gene_synonym="SCE29.08c"
FT                   /transl_table=11
FT                   /note="SCE29.08c, unknown, len: 289 aa; similar to
FT                   TR:O69952 (EMBL:AL023862) hypothetical protein from
FT                   Streptomyces coelicolor (282 aa) fasta scores; opt: 1391,
FT                   z-score: 1679.9, E(): 0, (72.3% identity in 285 aa
FT                   overlap)."
FT                   /db_xref="GI:4490986"
FT                   /db_xref="GOA:Q9Z4Z2"
FT                   /db_xref="InterPro:IPR001130"
FT                   /db_xref="InterPro:IPR012022"
FT                   /db_xref="UniProtKB/TrEMBL:Q9Z4Z2"
FT                   /translation="MTRIFDPHIHMTSRTTDDYEAMAAAGVRALVEPAFWLGQPRTGVS
FT                   SFTDYFDALLGWEPYRAEQFGIRHHCALALNPKEANDPRLAGVLDVLPDYLVRDRVVAV
FT                   GEVGYDAMTPQEDKAFTVQLELAVRHALPVLVHTPHRDKANGTRRTLDVVRESGIDPGL
FT                   VVVDHLNEVTVRAVADSGCWMGFSIYPDTKMSEDRMVALLREYGTARILVNSAADWGRS
FT                   DPLKTRRTADAMRAAGFGEDDVDQVLWRNPVAFYGQSGRLELDGPEGAEASGVRAEFEG
FT                   SSIRRGER"
FT                   /gene="SCO3239"
FT                   /protein_id="CAB38883.1"
FT   gene            complement(72731..73441)
FT                   /gene="SCO3240"
FT                   /gene_synonym="SCE29.09c"
FT   CDS             complement(72731..73441)
FT                   /product="conserved hypothetical protein"
FT                   /codon_start=1
FT                   /gene_synonym="SCE29.09c"
FT                   /transl_table=11
FT                   /note="SCE29.09c, unknown, len: 236 aa; similar to
FT                   TR:O69951 (EMBL:AL023862) hypothetical protein from
FT                   Streptomyces coelicolor (245 aa) fasta scores; opt: 416,
FT                   z-score: 464.9, E(): 1.4e-18, (45.5% identity in 220 aa
FT                   overlap)."
FT                   /db_xref="GI:4490987"
FT                   /db_xref="UniProtKB/TrEMBL:Q9Z4Z1"
FT                   /translation="MNPGGDGPRSLPDALAGALDRALAPDAAAWLEQACAAVRCEPGEV
FT                   EGTFAVAARRCGRGALDAGAEAGAGADAGTGLGAGWSVDDAARVLLLAALPVRGAALAA
FT                   VVSRLYRIGGGPERRAVLRSLSLLEAAGDLGDLGLPLVEDALRCNDPRLIAAAVGPYGA
FT                   RRLGAHAFRQAVLKCVFVGVPLDLVAALDARADAELDRMMADFAAERRAAGRALPPDVA
FT                   AYLHTHRVSTEATA"
FT                   /gene="SCO3240"
FT                   /protein_id="CAB38884.1"
FT   gene            complement(73438..74310)
FT                   /gene="SCO3241"
FT                   /gene_synonym="SCE29.10c"
FT   CDS             complement(73438..74310)
FT                   /product="putaive isomerase"
FT                   /codon_start=1
FT                   /gene_synonym="SCE29.10c"
FT                   /transl_table=11
FT                   /note="SCE29.10c, possible isomerase, len: 290 aa; similar
FT                   to TR:O69950 (EMBL:AL023862) hypothetical protein from
FT                   Streptomyces coelicolor (315 aa) fasta scores; opt: 1116,
FT                   z-score: 1331.4, E(): 0, (62.5% identity in 283 aa
FT                   overlap). Also similar to SW:XYLA_STRDI xylose isomerase
FT                   from Streptomyces diastaticus (388 aa) fasta scores; opt:
FT                   122, z-score: 148.8, E(): 0.56,25.0% identity in 296 aa
FT                   overlap."
FT                   /db_xref="GI:4490988"
FT                   /db_xref="GOA:Q9Z4Z0"
FT                   /db_xref="InterPro:IPR012307"
FT                   /db_xref="InterPro:IPR013022"
FT                   /db_xref="UniProtKB/TrEMBL:Q9Z4Z0"
FT                   /translation="MSAGTRFGYGTNGFGDHPLEDALAVLADLGYEGVGLTLDPRHLDP
FT                   FADDLPHRLRRLAARLDRLGLAVVVETGGRYVLDPWRKHQPVLMSAEGAGRRVDLLLRA
FT                   VRIAADLGAEAVSFWSGAAPADTPRQVVWDRLLAGCGTVVEAAARAGVVLGFEPEPGMF
FT                   VDTLDAYDELCRRLGGPHPLGLTLDIGHCRCLEPQPVADCVRRVADRLVNVQIEDMRRG
FT                   THEHLEFGSGEIDFPPVLSALAATGYRGLVSVELPRHSHAAPEVARRSLDFLRAADAGA
FT                   RPATRGAAA"
FT                   /gene="SCO3241"
FT                   /protein_id="CAB38885.1"
FT   gene            complement(74307..75182)
FT                   /gene="SCO3242"
FT                   /gene_synonym="SCE29.11c"
FT   CDS             complement(74307..75182)
FT                   /product="puitative transferase"
FT                   /codon_start=1
FT                   /gene_synonym="SCE29.11c"
FT                   /transl_table=11
FT                   /note="SCE29.11c, possible transferase, len: 291 aa;
FT                   similar to TR:O69949 (EMBL:AL023862) hypothetical protein
FT                   from Streptomyces coelicolor (363 aa) fasta scores; opt:
FT                   666, z-score: 682.9, E(): 9.9e-31, (51.3% identity in 312
FT                   aa overlap). Also similar to SW:UBIA_ECOLI
FT                   4-hydroxybenzoate octaprenyl transferase from Escherichia
FT                   coli (290 aa) fasta scores; opt: 137, z-score: 150.2, E():
FT                   0.47, (31.8% identity in 110 aa overlap)."
FT                   /db_xref="GI:4490989"
FT                   /db_xref="GOA:Q9Z4Y9"
FT                   /db_xref="InterPro:IPR000537"
FT                   /db_xref="UniProtKB/TrEMBL:Q9Z4Y9"
FT                   /translation="MSALPRVHDLARLVRAPAALSVPGDVLAGAAAARRPLGPGLLGMT
FT                   ASSVCLYWAGMALNDYADRDLDAVERPERPVPSGAVSPAAARAVGCGLTAAGLGLAALS
FT                   RGRRGLATALPLAGVVWAYDLVLKPTPAGAAAMAAARALNVLGGAGPGGLRRALPAAAT
FT                   VALHTGMVTRLSRYEVSGAPRAVPRQSLAVGGAVGAAVLLRGRRRPARDRVLAAGLTAV
FT                   YAYGGAAAQLAAARSPAAPQVRRAVAAGIHALIPLQAALTATAGRGAAGAALACALPWA
FT                   RRLGRKVSPT"
FT                   /gene="SCO3242"
FT                   /protein_id="CAB38886.1"
FT   gene            complement(75179..76345)
FT                   /gene="SCO3243"
FT                   /gene_synonym="SCE29.12c"
FT   CDS             complement(75179..76345)
FT                   /product="putative myo-inositol phosphate synthase"
FT                   /codon_start=1
FT                   /gene_synonym="SCE29.12c"
FT                   /transl_table=11
FT                   /note="SCE29.12c, possible myo-inositol phosphate synthase,
FT                   len: 388 aa; similar to many e.g. TR:O69948 (EMBL:AL023862)
FT                   from Streptomyces coelicolor (417 aa) fasta scores; opt:
FT                   955, z-score: 1034.1, E(): 0, (60.3% identity in 380 aa
FT                   overlap) and SW:INO1_CITPA myo-inositol phosphate synthase
FT                   from Citrus paradisi (grapefruit) fasta scores; opt: 323,
FT                   z-score: 352.1, E(): 2.6e-12, (26.9% identity in 364 aa
FT                   overlap)."
FT                   /db_xref="GI:4490990"
FT                   /db_xref="GOA:Q9Z4Y8"
FT                   /db_xref="InterPro:IPR002587"
FT                   /db_xref="InterPro:IPR013021"
FT                   /db_xref="InterPro:IPR016040"
FT                   /db_xref="UniProtKB/TrEMBL:Q9Z4Y8"
FT                   /translation="MRTGIWLVGARGSVATTTVVGAAALRAGLVPATGCVSALEAFDGV
FT                   PLPGFDELVFGGHDVVGTGLVKRAEQLAEAGVVPRGLPGVLTAELDAADAEIRPAPPGT
FT                   EEGGDGTPDQASAAGAIVADLTGFRERLGLDRVVVVNVSSTQPPAVPHPAHASAAALRE
FT                   ALARGERPLPVSSLYAYAALRAGCAFVDFTPSTGARLPALDELAREQGLPYAGSDGKTG
FT                   ETLVKSVLAPMFARRALRVRSWSGTNLLGGGDGATLADPERVVSKNASKGLVLEAELGH
FT                   AVEGGVHIHHVPDLGEWKTAWDHVTFEGFLGARMTLQFTWQGCDSSLAAPLVLDLARFM
FT                   ALAHRAGVAGPVPELGFFFKDPVGSAEHDLAAQYASLAAWARSVGAPA"
FT                   /gene="SCO3243"
FT                   /protein_id="CAB38887.1"
FT   gene            complement(76395..77192)
FT                   /gene="SCO3244"
FT                   /gene_synonym="SCE29.13c"
FT   CDS             complement(76395..77192)
FT                   /product="putative secreted protein"
FT                   /codon_start=1
FT                   /gene_synonym="SCE29.13c"
FT                   /transl_table=11
FT                   /note="SCE29.13c, putative secreted protein, len: 265 aa;
FT                   similar to SW:Y0BO_MYCTU hypothetical protein from
FT                   Mycobacterium tuberculosis (529 aa) fasta scores; opt: 116,
FT                   z-score: 133.8, E(): 3.8, (38.2% identity in 76 aa
FT                   overlap). Contains possible N-terminal region signal
FT                   peptide sequence"
FT                   /db_xref="GI:4490991"
FT                   /db_xref="InterPro:IPR006311"
FT                   /db_xref="UniProtKB/TrEMBL:Q9Z4Y7"
FT                   /translation="MSNHLDRRRLMTTALGGAAAVGLGAGAGLLGAAPAGAAERPVTPH
FT                   RGHDDFPDVPGMLGDRRANELWYMFDETTLYNVGPELEQAFTDIETALGDGWERAIFDA
FT                   WMAMAATSDYPNNFIEYVTPIKGPLQVLSKAQLGVFDTYYRPYGHGIVGAFADFAQGVL
FT                   NDPRRERPVHTMNGNPPPGYHIWFIFMRSMMLLDISRHRWERMAPINAMAWAIQTIAKP
FT                   SQFEVKEPLPRRVVAREAAKWLPRSVHRLDRDFLSYPLPEGMS"
FT                   /gene="SCO3244"
FT                   /protein_id="CAB38888.1"
FT   gene            complement(77260..78522)
FT                   /gene="SCO3245"
FT                   /gene_synonym="SCE29.14c"
FT   CDS             complement(77260..78522)
FT                   /product="putative salicylate hydroxylase (putative
FT                   secreted protein)"
FT                   /codon_start=1
FT                   /gene_synonym="SCE29.14c"
FT                   /transl_table=11
FT                   /note="SCE29.14c, possible salicylate hydroxylase (putative
FT                   secreted protein), len: 420 aa; similar to many e.g.
FT                   TR:P96555 (EMBL:AB000564) salicylate hydroxylase from
FT                   Sphingomonas sp. AJ1 (395 aa) fasta scores; opt: 830,
FT                   z-score: 827.2, E(): 0, (41.9% identity in 320 aa overlap)
FT                   and TR:G4104775 (EMBL:AF039534) salicylate hydroxylase from
FT                   Pseudomonas stutzeri strain AN10 (389 aa) fasta scores;
FT                   opt: 707, z-score: 706.0, E(): 5.1e-32, (34.7% identity in
FT                   401 aa overlap). Contains Pfam match to entry PF01360
FT                   Monooxygenase, Monooxygenase, score 91.00, E-value 2.4e-23.
FT                   Contains possible N-terminal region signal peptide
FT                   sequence"
FT                   /note="smCOG: SMCOG1087:hypothetical_protein (Score: 375.6;
FT                   E-value: 5.2e-114);"
FT                   /db_xref="GI:4490992"
FT                   /db_xref="GOA:Q9Z4Y6"
FT                   /db_xref="InterPro:IPR002938"
FT                   /db_xref="InterPro:IPR003042"
FT                   /db_xref="UniProtKB/TrEMBL:Q9Z4Y6"
FT                   /translation="MPKLRIAVVGGGIGGLAAALALTRKGHEVRVYEQAPELREAGVGM
FT                   HLGPNGSRLLERWGLGERLRALGVRPAGMEVRDWSHGGTLVRQPMGEEWLAEFGAPYYT
FT                   IHRADLHTMLAESLPSGTVRAGHRLERFTETGGGVRLEFADGSTAGADVLIGADGAHSV
FT                   VRRTLAGPDTAVFSGQSAFRGVVARDQVPGLPGDTLLVWAGPDARMLVYPVRGGRFLTF
FT                   VAVVPDPRWRLESWSAPGDLDELAARFDGWNTDVKSLVAAVRESRRWALYDREPLARWS
FT                   AGAVTLLGDAAHPMLPHHGQGVSQAVEDAAVLAHCLDAPTGPDPSASVSAAAAASAPAA
FT                   AAASAPAARRAIAAALDAYEGVRRPHTTRVQLGSRGGGSQRLRPDEDGTESTGTMSSLV
FT                   EDVSWIQRHDAEAGLPPLPPP"
FT                   /gene="SCO3245"
FT                   /protein_id="CAB38889.1"
FT   misc_feature    complement(77398..78075)
FT                   /note="Pfam match to entry PF01360 Monooxygenase,
FT                   Monooxygenase, score 91.00, E-value 2.4e-23."
FT                   /gene="SCO3245"
FT                   /gene_synonym="SCE29.14c"
FT   gene            complement(78569..79561)
FT                   /gene="SCO3246"
FT                   /gene_synonym="fabH4"
FT                   /gene_synonym="SCE29.15c"
FT   CDS             complement(78569..79561)
FT                   /product="putative 3-oxoacyl-[acyl carrier protein]
FT                   synthase III"
FT                   /codon_start=1
FT                   /gene_synonym="fabH4"
FT                   /gene_synonym="SCE29.15c"
FT                   /transl_table=11
FT                   /note="SCE29.15c, fabH4, probable 3-oxoacyl-[acyl carrier
FT                   protein] synthase III, len: aa; similar to many eg.
FT                   SW:FABH_ECOLI 3-oxoacyl-[acyl carrier protein] synthase
FT                   III, FabH, from Escherichia coli (317 aa) fasta scores;
FT                   opt: 765, z-score: 862.6, E(): 0, (40.8% identity in 314 aa
FT                   overlap). Also similar to two from Streptomyces coelicolor
FT                   - TR:O54151 (EMBL:AL021409) (335 aa) fasta scores; opt:
FT                   694, z-score: 782.9, E(): 0, (53.5% identity in 331 aa
FT                   overlap) and TR:E1359140 (EMBL:AL034443) (316 aa) fasta
FT                   scores; opt: 685, z-score: 773.2, E(): 0, (40.6% identity
FT                   in 313 aa overlap)."
FT                   /note="smCOG:
FT                   SMCOG1084:3-oxoacyl-(acyl_carrier_protein)_synthase_III
FT                   (Score: 355.8; E-value: 3.2e-108);"
FT                   /db_xref="GI:4490993"
FT                   /db_xref="GOA:Q9Z4Y5"
FT                   /db_xref="InterPro:IPR004655"
FT                   /db_xref="InterPro:IPR013747"
FT                   /db_xref="InterPro:IPR013751"
FT                   /db_xref="InterPro:IPR016038"
FT                   /db_xref="InterPro:IPR016039"
FT                   /db_xref="UniProtKB/Swiss-Prot:Q9Z4Y5"
FT                   /translation="MSAARGGRAGAVVTGVGTCLPETVVDNDEVSRHLDTDHAWIHSRT
FT                   GIERRRRVSPGTTTGDLAVTAGAAALKSAGRDDCDLVLLATTTPDRRCPATAPRVASRL
FT                   GLRAAAAFDLSAVCSGFVYGLSVASAMITAGTCDRALVIGADVYSSIVDPDDRGTAVVF
FT                   GDGAGAVLLERGDTGDPGAVLHTELGSDGTGDELITIPPDGAYLTMRGSDVYTRAVTTM
FT                   AESARSTAAHAGWDLADVDAFVGHQANLRILTSVAKRLRLPPERVVSNIADVANTAAAS
FT                   IPLALADAAAQGRIGSGDRLLLTAFGGGLTWGSAAVVWSGAEPVQDQRS"
FT                   /gene="SCO3246"
FT                   /protein_id="CAB38890.1"
FT   gene            complement(79558..81360)
FT                   /gene="SCO3247"
FT                   /gene_synonym="SCE29.16c"
FT   CDS             complement(79558..81360)
FT                   /product="putative acyl CoA oxidase"
FT                   /codon_start=1
FT                   /gene_synonym="SCE29.16c"
FT                   /transl_table=11
FT                   /note="SCE29.16c, possible acyl CoA oxidase, len: 600 aa;
FT                   similar to many acyl CoA oxidases, especially from
FT                   eukaryotes e.g. SW:CAOP_RAT acyl CoA oxidase from Rattus
FT                   norvegicus (rat) (661 aa) fasta scores; opt: 462, z-score:
FT                   477.6, E(): 2.7e-19, (27.8% identity in 425 aa overlap).
FT                   Contains PS00017 ATP/GTP-binding site motif A (P-loop)."
FT                   /note="smCOG: SMCOG1006:acyl-CoA_dehydrogenase (Score:
FT                   133.0; E-value: 1.56e-39);"
FT                   /db_xref="GI:4490994"
FT                   /db_xref="GOA:Q9Z4Y4"
FT                   /db_xref="InterPro:IPR006090"
FT                   /db_xref="InterPro:IPR006091"
FT                   /db_xref="InterPro:IPR009075"
FT                   /db_xref="InterPro:IPR009100"
FT                   /db_xref="InterPro:IPR012258"
FT                   /db_xref="UniProtKB/TrEMBL:Q9Z4Y4"
FT                   /translation="MTQREEELARVLSGPEFATIRPDDLSVLDYSLLTLRRARLLNGAG
FT                   FAANSLWLGRGDSARFPEFLRTMGWIGAYDLSLLNVLVSHQIAGDALLSHGGPEQLDAW
FT                   AGEIDAMERMYCFAGSELLAGSDLKRVRTTAVYDPHGRSLVLNTPRPADSKVWTGNSLH
FT                   TGDVAMVLARLEVGGRDEGHHWLRVPLREAGAVLPGVRIGRAEPKGGVTANQTGVLTFT
FT                   DHRLPLSALMNRWASIDEDGTYRSPLPRHRRFEECLATFTHERLFPSVGAAYAQLLACT
FT                   ITTRFAAVKQTFGRPLIGHEHYRMRLSAAVGRSLAARHAMTALAEVAVARSAEGAPARD
FT                   QVLHALISCGKSGCTGDARQTLAETRELCGGLGYHDANQIAPLLHDYEIAVTFGGDNTV
FT                   LGYQATRFALRHREDFDRVLDEAVAGAGRLDAVRVLRAVCDVLLDRVERDGAGEASAQW
FT                   SRAVHQTLAIGHWARQASTPLSERLLAQYAAVCVLEHALAALRAGILDQDALLGFEAAR
FT                   HEAAGAPLDADALLRELAVPEGLISAPIAHPDFAERHAAAAHAGTAAAHAGTVPSPGTG
FT                   PSPGTGPAPGTVQAPGTVQAGVRP"
FT                   /gene="SCO3247"
FT                   /protein_id="CAB38891.1"
FT   misc_feature    complement(80305..80328)
FT                   /note="PS00017 ATP/GTP-binding site motif A (P-loop)."
FT                   /gene="SCO3247"
FT                   /gene_synonym="SCE29.16c"
FT   gene            complement(81410..82630)
FT                   /gene="SCO3248"
FT                   /gene_synonym="fabF3"
FT                   /gene_synonym="SCE29.17c"
FT   CDS             complement(81410..82630)
FT                   /product="putative 3-oxoacyl-[acyl carrier protein]
FT                   synthase II"
FT                   /codon_start=1
FT                   /gene_synonym="fabF3"
FT                   /gene_synonym="SCE29.17c"
FT                   /transl_table=11
FT                   /note="SCE29.17c, fabF3, probable 3-oxoacyl-[acyl carrier
FT                   protein] synthase II, len: 406 aa; similar to many e.g.
FT                   TR:O54149 (EMBL:AL021409) 3-oxoacyl acyl carrier protein
FT                   synthase II from the Red cluster of Streptomyces coelicolor
FT                   (407 aa) fasta scores; opt: 1217, z-score: 1314.2, E(): 0,
FT                   (50.1% identity in 407 aa overlap) and SW:FABF_ECOLI
FT                   3-oxoacyl-[acyl carrier protein] synthase II FabF, from
FT                   Escherichia coli (412 aa) fasta scores; opt: 843, z-score:
FT                   912.2, E(): 0, (35.4% identity in 404 aa overlap). Contains
FT                   Pfam match to entry PF00109 ketoacyl-synt, Beta-ketoacyl
FT                   synthase, score 92.60, E-value 7.7e-24 and Prosite match
FT                   PS00606 Beta-ketoacyl synthases active site."
FT                   /note="smCOG: SMCOG1022:Beta-ketoacyl_synthase (Score:
FT                   348.8; E-value: 7.6e-106);"
FT                   /db_xref="GI:4490995"
FT                   /db_xref="GOA:Q9Z4Y3"
FT                   /db_xref="HSSP:1E5M"
FT                   /db_xref="InterPro:IPR000794"
FT                   /db_xref="InterPro:IPR014030"
FT                   /db_xref="InterPro:IPR014031"
FT                   /db_xref="InterPro:IPR016038"
FT                   /db_xref="InterPro:IPR016039"
FT                   /db_xref="UniProtKB/TrEMBL:Q9Z4Y3"
FT                   /sec_met="NRPS/PKS subtype: PKS/NRPS-like protein"
FT                   /sec_met="NRPS/PKS Domain: PKS_KS (65-404). E-value:
FT                   6.6e-52. Score: 168.1;"
FT                   /translation="MTEGPAAITGVGLVTPAGTDADSTWEAMCAARSLEGGDPEPLAGT
FT                   GAWHSLRVPALRPGQLTGRGTARTDPFIRFALVAVAEALAQSGLDPDSWDGSRVGVVVG
FT                   SAFGGVTTHDEQHRRLERQGAAMVSPYLHPRALINMAAGTIGARYGITGPGHTVAAACA
FT                   SGASAFGLGKTLLDAGVCDTVVVCGTDAAVTPLVVSGFARMGALSEQKATDASRPFGAD
FT                   RDGFVMSEGAAAVVMEKPAKARARGAEVLGRLLGHADTSDAHHPTAPRPDGAGAAAAVE
FT                   RALAAARMSVRNVTTVNAHGTSTPQNDLTEARLIARLFPHGPSVTANKGLLGHTLGAAG
FT                   AIEAVLTLRSLRTGVLPPIAHTERADPGLPELDLVLGGVRRHDGNVAVSTSFGFGGSNC
FT                   ALVLDAG"
FT                   /gene="SCO3248"
FT                   /protein_id="CAB38892.1"
FT   misc_feature    complement(81413..82615)
FT                   /note="Pfam match to entry PF00109 ketoacyl-synt,
FT                   Beta-ketoacyl synthase, score 92.60, E-value 7.7e-24."
FT                   /gene="SCO3248"
FT                   /gene_synonym="fabF3"
FT                   /gene_synonym="SCE29.17c"
FT   misc_feature    complement(82124..82174)
FT                   /note="PS00606 Beta-ketoacyl synthases active site."
FT                   /gene="SCO3248"
FT                   /gene_synonym="fabF3"
FT                   /gene_synonym="SCE29.17c"
FT   gene            complement(82627..82872)
FT                   /gene="SCO3249"
FT                   /gene_synonym="SCE29.18c"
FT   CDS             complement(82627..82872)
FT                   /product="putative acyl carrier protein"
FT                   /codon_start=1
FT                   /gene_synonym="SCE29.18c"
FT                   /transl_table=11
FT                   /note="SCE29.18c, probable acyl carrier protein, len: 81
FT                   aa; member of a large family including SW:ACP_HELPY acyl
FT                   carrier protein from Helicobacter pylori (78 aa) fasta
FT                   scores; opt: 121, z-score: 179.0, E(): 0.012, (37.5%
FT                   identity in 64 aa overlap). Contains Pfam match to entry
FT                   PF00550 pp-binding, Phosphopantetheine attachment site,
FT                   score 31.20, E-value 5.3e-07."
FT                   /db_xref="GI:4490996"
FT                   /db_xref="GOA:Q9Z4Y2"
FT                   /db_xref="InterPro:IPR006163"
FT                   /db_xref="InterPro:IPR009081"
FT                   /db_xref="UniProtKB/TrEMBL:Q9Z4Y2"
FT                   /sec_met="NRPS/PKS subtype: PKS/NRPS-like protein"
FT                   /sec_met="NRPS/PKS Domain: ACP (7-56). E-value: 4.7e-09.
FT                   Score: 27.8;"
FT                   /translation="MSTDPKSVVHGILAEDLEVDPAEITDGASLRNLELDSLAVAELIV
FT                   RIKEETGVDLSGDETRIADLTVGEVVLLAGSGLEAA"
FT                   /gene="SCO3249"
FT                   /protein_id="CAB38893.1"
FT   misc_feature    complement(82696..82854)
FT                   /note="Pfam match to entry PF00550 pp-binding,
FT                   Phosphopantetheine attachment site, score 31.20, E-value
FT                   5.3e-07."
FT                   /gene="SCO3249"
FT                   /gene_synonym="SCE29.18c"
SQ   Sequence 82872 BP; 10726 A; 31202 C; 30262 G; 10682 T; 0 other;
     tcacgcaccg ccgcgcagct cacgcagcaa ccgggcgact ccgaaggcga gttcgatcga        60
     ctgggcggcg ttcagccggg gatcgcaggc cgtctcgtac cggctggcca ggtgggtgtc       120
     cagcacctcg tcgaggtcgc cgccgaggca ctcggtgacg tcgtcgccgg tgagttcgag       180
     atggatgccg cccgggtgca ggccctcctc gcggtgcacc gcgaagaact cggccacctc       240
     ggtcgtgatg tccgagagcc ggcgggtctt gtagccgctc gcggagacga aggtgttccc       300
     gtgcatgggg tcgcaggccc acaccggggc gtgtccggcg tcccgcacgg cccgcagcag       360
     cggcggcagc agctccgcgc cgcgcccggc gccgagcctg ctgatcagga cgagccggcc       420
     cggcgcccgg tcggggtcca gccgctcgca cagttcccgc aggtcgtcga cgcccatggt       480
     gggccccacc ttgacgccga ccgggttgtc caccccggcg agcagttcca cgtgcgcgcc       540
     gtcgacgcgg cgggtgcggt cgccgatcca cagcaggtgc gcactggtgt cgaaccagcc       600
     ccgccgcttc tcgtcgtacc ggatcagcgc ctgctcgtac tgcggcagca gcgcctcgtg       660
     cgaggtgtag agctggacct ggtgcagggc ggcctgggag cgggtgtcca ggccgcaggc       720
     ggacatgaac ctgagggccc aggtgatgtc gtcggcggcc ttctcgtacc gctgtccggc       780
     ggggctgcgc cggacgaact cctggttcca ttcgtggacc tggcccaggt cggcgtagcc       840
     gcccagggtc agcgcccgca gcacgttcag ggccgccgag gcgtggtggt aggcgctcag       900
     cagccggccg gcgtccgggc ggcgggcctc ggcggtgaac tcggggccgt tgacgatgtc       960
     cccgcggtag acgggcagtt cgacgccgtc gacggcctcc gtggggcggc tgcggggctt      1020
     gccgaactgg ccggcgatcc tgcccacctt caccaccggc agcccggagc cgtaggtgag      1080
     caggatggcc acctggagga tgacccgcag cttgccgcgc acccctgcct cggtgcagga      1140
     cccgaaccgc tccgcgcagt cgcccgcctg gagcaggaag ccctcccccg cggcgacctg      1200
     ggccagggag cggcgcaggt cgaggatctc gtcgggcagc accaggggcg gcctgagcgc      1260
     gagggtgtcc tccacgccgc gcagttcccc ggggtcgggc cactcaggct gctgcgcggc      1320
     cggccggctc cgccacgagc cgggggtcca tccgccccgc ccggcgtcgg ccgcggggcc      1380
     ggtcgggccc ggggccgcgg tgccggtccc ggccggggcc gtgcggggtt gcgtgtacgt      1440
     gtcgctcgcc gtcatccgac cagtcccttg atcgtggtac cggggtcacc ggcccgcatg      1500
     agcagttctc cgaccaggac cgcgtccacc ccggccgctt ccagcgcgcg ggcgtcgggt      1560
     gcgccgcgca cgccgctctc cccgaccatg acccgcccgg tgccgacccg cccccgcagc      1620
     cgggccgaaa gggtccggtc gatcgagaag tcccgcaggt cgcggtggtt gacgccgatc      1680
     acgtcggcgc ccgcctccag ggccacgtcc acttcccgtt cgtcgtgcac ctcgaccagc      1740
     gcctccatgc cgcaggcacg ggtgcgggcc aggagtgcgg cgagccgtgc gggggcgagc      1800
     gcggcgacga tcagcagcag ggcgtcggcg ccgagcgccc gggcctccag gatctggtac      1860
     tcgtcgacga cgaagtcctt gcgcaggacg gggagttcgc aggccgcgcg ggcgacggcc      1920
     aggtggtccg ggctgccgcc gaagcccgcc tcgtgggtga gcaccgacac ggcgtgggcg      1980
     ccgccgccct gataggcgcg ggccagttcg gccggccggt agtcgtcggt gagcggcccc      2040
     ttggaggggc tgcggggctt catctcggcg atgaccgcga gcccgggttc gcgcagcgcg      2100
     gcggcgaagt cccgggccgg gggcgccgcg gcggccagct cggtcagctt cgcctcggtg      2160
     cgcagcgcgc gccggcgccc ggtctgcgac tcggcctcgg cgacgaggcc ggcgaggatg      2220
     ccgctcatgc cggcacctcc accaggtccg cccgctgcca ggaggcgtgg gcccagcggt      2280
     cgagcaggcc ggcggcggcg cccccgtcga cggcggacgc tgccagccgc agcccgtcgg      2340
     accaggtgcc ggccacgccg gcgacccgca gcgccgcggc ggcgttgagc aggacgacgt      2400
     cccgcgcggg tccgcgcccg ccggccagga cacggcgcag gacggccgcg ttgacggcgc      2460
     ggtcgccgcc cgccaggtcg ccggggcggg accgggccag gccgtgctcg gcggggtcga      2520
     agcggtgggt ggtgcgccgt ccgtcgcgca gttcgaccag gtgggcgggg gcggcggtgc      2580
     tcagttcgtc catgccgtcc gcgctgtgga aaaccagggc gcgggtgacg ccgagtcgtt      2640
     cgaggacctc ggtcatcggt tccaccagct cgcggctcgg cacccccagg gtgcgcagcc      2700
     gggcgcccga ggggttgcac aggggtccca gcaggttgaa gacggtccgc gcgcccagtt      2760
     cccggcgcgg tcccgccgtg tgccggaagg ccgggtggaa gaccggggcg aacaggaagg      2820
     tgatcccggt gcggtccagg caggcggcgg cctcctcggc gccgaggtcg atgcggacgc      2880
     ccagttcctc cagcacgtcg gcgctgccgc aggcggagga cgcgctgcgg ttgccgtgct      2940
     tggcgacccg taccccgcag gcggcggcga cgatcgcggc ggcggtggag atgttgaagg      3000
     tgttcagccc gtcgccgccg gtcccgcagg tgtcgagcag atcgccgccc gcgcgcggga      3060
     ccggggtggc gaactcctgg gcggcgcggg ccatgccggc caggttgtcg gcggaggcgc      3120
     cgcggaccgt gacggccagt gcgaaggcgg cgatctgggc ggccgtggcc tcgccgcgca      3180
     tgatcacgcg catcgcgtcg gccgcctcgg cctcggtgag gggccgttgc acgagcgttc      3240
     tcagtgactc aatcatcggc gcactccagg aagttcgcga tcagctgctt gccctcgggg      3300
     ctgagcaccg actcggggtg gaactgcacc ccgtggaccg ggtgcgtgcg gtggcgcagg      3360
     cccatgaccg tgccgtccgc ggtgcgggcg gtgacggtca gctcgtccgg caggccggcg      3420
     ggctcgacca cgagcgagtg gtagcgggtg gcgctgaacg ggtcgggcag gccggcgaac      3480
     accccgccgc cgtcgtggtg cacggcactg gccttgccgt gcacctgctc gccgcgcacc      3540
     accgagccgc cgtaggcgac ggcgacggcc tggtggccca ggcacacgcc gaggacgggc      3600
     agccgtgcgc cgagtgcgcg gaccgcgtcc acgcagatgc cggcgccggc gggggtgccg      3660
     gggcccggcg agagcagcag caggtcgaat ccggcgagtt cggcgacggt gacggcgtcg      3720
     ttgcggaaca ccgtggggcg gccgcccagt tcggcgacgt agtggacgag gttgtaggtg      3780
     aacgagtcgt agttgtcgat caccgcgacc cgtggcgccg cgcccgcgcg ggtgccggtg      3840
     ggggcgctca tgccgccgcc tccgcccgcc gtacggccgt gagcatggcg cgcgacttgt      3900
     gcagggtctc gcggaactcg gccgcggggt cggagtcggc gacgatcccg gcgcccgcct      3960
     gcacgtgcac gtggccgtcg gcgacgacca tggtgcgcag ggcgatggcg aagtcggtca      4020
     gaccgtccgc gccgacgaag ccgagggcgc cgccgtacac cccgcgctgc tcgggctcca      4080
     gctcggcgat gatctccatg gcccggatct tgggcgcccc ggagagcgtt ccggcgggga      4140
     aggccgagcg cagggcgtcc agcgcgtccc ggccctcggc gagccgtccg cgcacggtgg      4200
     acgacaggtg catcacgtgg gagaagcgct cgacccgcat cagccgctcc acccggaccg      4260
     tgcccggctc ggtgacccgg cccaggtcgt tgcgaccgag gtcgaccagc atgacgtgtt      4320
     cggcgcgttc cttctcgtcg gcgcgcagct cccgctccag ccgcaggtcc tcggcggggt      4380
     cggggtggcg gggccgggtg cccgcgaggg gccgggtgcg caccgtccgg ccctccgcct      4440
     tgacgagcag ctcgggcgag gcgccgatca cgtgccggcc tcctcccagg ctcaggtggt      4500
     acatgtacgg cgaggggttg gtggcccgca ggtgccggta caggtcggtc ggccgggcgc      4560
     gcagcggcct gctgagccgc cgggagagca cgatctggaa ggcgtcaccg gccgcgatgt      4620
     gctcccgggc gcgggcgacc cgctcggtga actgtgcctc ggtgaggttc gcggtccagc      4680
     cctgcgtccc gtggtcggcc ggcgtggcgg cggcgagcgg gcggccggag aaggcggcgg      4740
     gtgccggcgc gcggcgcagg gcgcggttga ggcgcacgat gcgggcgacg gcgtcgtcgt      4800
     aggactcgcg ggccgggcgg tagagggtca tcagcaggac gcgccgggtc gcgtggtcga      4860
     agacgacgag gtcgtcggcg gcgaggaagg cggactcggg cagtccgggc ggcggtccgg      4920
     cggccagggg caggtcctcg aagtggcggg ccgcctcgta cccgaggtag ccgacgacgc      4980
     cgccgtggaa cggcggcagt ccgggcaccg gcgccacgga ccgggccagg tgggaccgca      5040
     gcgcggtcag cgggtcgccg ccggtcggct cgagcggcac cggtcggtga ccgacgtacg      5100
     agtaccgtgc cacgccgccg gagaccggca cgctctccag caggaagccc gcctcgtccg      5160
     gtccgcacag ctgggcgaag gcggtgacgg ggctgaccga gtcgtccagg aactcctggt      5220
     ggagcgggac gacgtcgtgc tcgcgggcga gtgccgcggc ggcggcgcgg tgcgggacgg      5280
     tggcgcgggc ggcctcctcg gcctccgtcg cgtccggagt cttctgtgag cccggtgcgc      5340
     cctgtgggtc cgtcgtgggc gcctcggcgg cgtgggtggt catgccgcct tcccggcggt      5400
     ggccgagacc cggcccactc cgacgacggc acgccgcgga atggtgacgc gccacccgcc      5460
     ggtgccctcc tggcgcagtt cgctcgaggc gaggccgccc tcggcgtccg ggtagcggaa      5520
     gacggccttg gcggtctcgg cgacccagcg gtacgcctcc tgctcggtgc gcccctcgaa      5580
     gaccttgacc aggccgtaca tgttcagcag gtaccggccg atctccagct ccgcctcctc      5640
     gggggtggcg gcgaccgcgg tgtaggggtc gtcgatctcc acgacctcgc ggtggtcgta      5700
     gccggccttc tccaggtatc cctcgatctc gtcccgggtg aagtgcagga acttgtggcc      5760
     ggtcgccgag tacacgtcgg tgacctcctc gaaccacacg tccacgggcg agccgacgag      5820
     gaagtcgtgc aggacgaacg tgccgccggg gcggagcatc cggcgggcct cggtggccac      5880
     cgtctgccgg tccgaggacg gcacgtggtg cgagccgtag gccagcagta cggcgtcgac      5940
     gctgtggtcg cgcagcagcg gctgctcggc ccgctggagc agggcgggca cgccggccgc      6000
     ccacgccgtg gtcaccatgt ggggggacgc gtcgcaggtg aggatgttga agtcgccgat      6060
     gcccagctcc tcgcagacct tgcgcaccag tccgtcgccg ccgagcaggt cgaccaggac      6120
     gggccggtcg ccggccgcgg tgcggcgggc ggtctcggcg aagccgagga gcttcctgat      6180
     ccccgtctcg cgggcgcgcc ggttgagggc ctgggcctgt acgtactcca cgccccggct      6240
     gccctcgccg tcggcgccga agtcgtcgtg ccgcccgggg gcgctgcccc tggccgcctc      6300
     ccaggcggcg atccgccggg ggtcggccag ggcgtgcagc tcggggtggc tccgccgcag      6360
     ttccgccagc tgcccctgca cgtcgtcccc ggtcacggtg ggtccgctcg tctgtgcgcg      6420
     catgcgtcgg gatctcctcg ggtgggggtg gacgcgggca agacgatgcc cgccgggcct      6480
     gcccgcacga cggtaggagc gtcaactttc tcctcgatat cgattggttt tcgccccgcc      6540
     cggccaagat ccgtccctgt cgaaagtaag gcccaagaga cgtcgttcgt gcctggtgac      6600
     ggcggatgac gggctcctac agtcacttcg cgggggacgc agccgagacc ggaactgagc      6660
     gcggagtcga gcccggaggg cgtcagggat gaagaaccag ttggacgagc cggggggcgc      6720
     ggtccgcgtc ggcgggggtg gcggcctgag cgcggcggag gtcgccgaac gggtcgcggc      6780
     ggggcaggtc aacgacgtac cggcgcggtc gagccgcacg atcggggaga tcgtccgcag      6840
     caacctgttc acccgcatca acgcgatcat cggcgtgctg ttcgtcatcg tgatgatcgt      6900
     cgggccggtg caggacggtc tgttcggcgg cgtcatcctc gccaacaccg cgatcggcat      6960
     catccaggag gtgcgcgcca agcggaccct ggaccagctg gcgatcgtcg gcgagagccg      7020
     gccgcgggtg tggcgggacg ggcagcggct ggaactcagc gcctccgaga tcgtcatcga      7080
     cgactccatc gacctcggtc agggcgacaa gatcgtggtg gacggcaccg tcacctcggg      7140
     cgacagcctg gaggtcgacg agtcgctgct caccggcgag gccgacccgg tggtcaagca      7200
     gcccggcgac ccggtgatgt ccggcagttt cgtggtggcc ggctcgggga cgttcaccgc      7260
     cacccgggtg ggcaaggagg cgtacgcctc gcagctcgcc gacgaggcgc ggcgcttcag      7320
     cctcgtcaac tccgagctgc gcaacggcat cgaccggatc ctgaagttcg tcacctacgc      7380
     gatcgtcccg gcgggcatcg cgctgatcat cacccagttc gtggtgaacg acgacaactt      7440
     ctcggaggcg atccggcgca tggtgggcgg tctcgtcccc atggtgcccg agggcctggt      7500
     gctgctgacc tcgctggcct tcgcggtcgg cgtggtccgg ctcggcaaga agcagtgcct      7560
     cgtgcaggag ctgcccgcca tcgaggggct ggcgcgggtg gacacggtct gcctggacaa      7620
     gacgggcacg ctcaccgagg cgtcgatgga cgtcgacgag gtccttccgc tgctgccgga      7680
     gctgccggtc gacgcggtgc tcggtgccct gggcgccgcc gacgagcggc ccaacgccag      7740
     cctccaggcg atcatcgagt cgtaccccgc ccccgagggc tggcggcgca ccgccaccgc      7800
     gccgttctcg tccgcccggc gctggagcgg cgcctccttc gccgagccct ccggcacgga      7860
     gtcggcgtgg ctgctggggg caccggacac gatgctgccg gccgggcact cggtgctcac      7920
     cgccgccgac tcctacgggg cccggggcct gcgggtcctg ctcctggcgc gcagcgaccg      7980
     gccgctggac acgctgatgg acgaccccgc ggccgtgccc gccgccgtca cggccgccgc      8040
     gctcgtcgtc atcaagcagc gggtgcggcc ggaggcgcgg gccaccctgg actacttcgc      8100
     cgaccagggc gtcacggcca aggtgatctc gggcgacaac gcggtctcgg tgggagccgt      8160
     ggcgtcgagc ctgtcgctgc ccggggcgga acggccggtg gacgcccggt tcctgccgga      8220
     cgagccggcc gaactggccg acgcggtcga ggagaacacc gtcttcggac gggtggggcc      8280
     gcagcagaag cgggacatgg tgggcgcgct ccagtcccgc gggcacaccg tggcgatgac      8340
     gggcgacggc gtcaacgacg tcctcgcgct caaggacgcg gacatcggcg tggggatggg      8400
     ctcgggcagc ccggccaccc gggcggtcgc gcagatcgtc ctgctgaaca acaacttctc      8460
     ggcgctgccc tcggtggtcg cggaggggcg ccgggtcatc ggcaacatcg agcgggtggc      8520
     caacctcttc ctcaccaaga ccgtctactc ggtgctgatg gcgctggtgg tcgtgatcgc      8580
     ccaggtgccc tacccgttcc tgccgcgcca catcacgctg gtcgggtcgc tgaccatcgg      8640
     catccccgcg ttcttcctcg ccctcgcgcc caacaaggag cgggcccggt ccaacttcgt      8700
     cggccgggtg ctcaggttcg cgatcccggc cggcgcgctc gcggccgccg ccacctcggt      8760
     cgcctatctg atcgcccggt cggtgtacga cgacaacctg gacgccgaga cctcggcggc      8820
     gaccctcgcg ctgttcctca cggccctgtg ggcgctggcc gtcatcgccc gcccctacac      8880
     ctggtggcgc gtgctgctgg tgctgaccat ggcggtgggc ttcgccgtgg tgctggtggt      8940
     gccctacctc caggagttct tccagctgaa gctggtcggc gtcaccgcgc cgtgggcggc      9000
     ggtcgcctgt gcggcggtcg ccgggctggt gctggagttg gtgtgggcac gtatgcggcg      9060
     tcgtctcgac gccgactgag cccaccgggc ggtcgacccc cgtaccgccc ggtgaagagg      9120
     aggggacgcc cggtccgtgc cgggcgtccc ctccgtcttt gtgcgccccc cgccgaccgg      9180
     aacggcacga tccggccaaa cctgcgcagc ggtgcggccg gaggagccgc ttccgggccg      9240
     ttcgacgggc ggcccgccac gggaccggaa cgagccccgg catccgccgc caccagcgga      9300
     tttcacattc cttacgcaat cggcggcgag agcgaccggc aggtaacctc ggggctgaat      9360
     ccaggccatc ggggaatagc aaacggcgca ctgacgaaag caagggcaga gacctgccga      9420
     aagttgagtg ttggattcaa agaagatccg tattattccg actgcaggca ggggggagcc      9480
     ggctacgaag gaaaagttcc gcaggtcaga ttgggccggg tcgcaggcag cgccgcaccg      9540
     gcaaccacga ccgcgacttt cgtcgacgca ccccctcgca ccgccgcccg gccaccggtc      9600
     cgggcgcacg acccgaaggg aagtgaggct cacgcacgga ccagcagctc ctgacgcagc      9660
     gacccggacc cggaggtgag tgacatgacg acgaggcccc gaccagcggt gaaccctgct      9720
     gacccggccg taacgaagtc ttcatgcccg tggcacccga cggcttcgga gagtttcggc      9780
     acgcagacat cagcacaact tgacgcgggg gtatcaagag gtcatggatc ttcggctgat      9840
     agaaccgata taccagagaa tcggaaatgc ggaagtctcc caaaaggaaa ccccgaccgc      9900
     cggtctcgaa ttcggagtgc tcgggccact cgaagtgcac atgaatggcc gaggtcttac      9960
     ggtgggcggc ccccggcaac gggccgtgct ctccgcacta cttctctccg ctaatcaggt     10020
     cgtttctttc gactccctga tcgaggaggt ctggaacggc cgtccgccca gtaccgcgcg     10080
     cacccaggtg gccatttgca tcgccacact gcgcaaaatc ttccgtaccg cgggctggga     10140
     acaggaaacc atcatcacgg ccacacccgg ctacatgctc agcctcgccg gccactcact     10200
     cgactcgctc cgtttcgaac aactggtctc cagagccacc gaactgacgg cggacgaacg     10260
     tccggccccg gcggccgagg cgctgcgcca ggccctggcc ctgtggcgcg gccccgccct     10320
     gggcggcgtc cacgcaccct tcgccgagac cgaggcggcc cggctggacg aacagcgcat     10380
     gctggccgtc gaacagcaca tggcgctgcg cctccaactc ggcgagcacc agtcggtcct     10440
     gggcgaactc caggcactgg tcggtgcctg cccgctgcgc gaccggctgc gctactacct     10500
     gatgctcgct cagtaccgtt cgggacggcg ggcggaggca ctcacgacat tccgcgacgg     10560
     aatgcggtat tccatcgaag agatcggtct tgaactgggt accgacctcc agtcgctgca     10620
     cgactcgatc ctgcgcgacg aattcccgca gctcggcgtc ctgggcatag cggcggcgcg     10680
     aaaggaccgg cagcagaccg ttccgagtca gcttccggaa agcgacgcct acttcatcgg     10740
     gcgtagccgc gagcagtggt tgatggatga tgtgctgctc gacggatcgg cgcagaatcc     10800
     gcccgccatc gcctacctca ccggaagtcc cggaatcgga aagacgagcc tggcggtcaa     10860
     ctgggcgcac cgtgcggcgc acagatttcc cgacgggcag ctcttcgccg acctgcggga     10920
     gggcggcccg ctggaggtgc tccaccagtt cctgcgccag ctgggggacg agggtccgct     10980
     gcccgccgag cccgcggagg cggcggagcg gtaccgcgga ctgctggagg gccggcgggt     11040
     cctgatcgtg ctcgaccacg cctcctccta cgcccaggta cgtcatctgc tgcccacgag     11100
     cggcgggtgc tgcgtactca tcaccggccg ggccaatctg gacgagctga tgcagaagta     11160
     ccgcaccttc cggctgcggg tcgcgcccct gtcggacgac gaggcgcggg agacgctggc     11220
     cggcgtgctg cgggactcac gggcgcagga cgtgcccgag gcgaccagca ggctcgccgc     11280
     gctgtgcggg cattcgccgc tggcgctgcg ggccgccgcg gccaggctgc tcaccaagac     11340
     gcactggcgg gtgctcgacc tggtatgccg gctggaacgc tcgggcgacc ggctgacggc     11400
     cctcagcatc ggggaggact cgctgcgcgc ccggctggac cgcagcatgc gggagctgga     11460
     ccccagggtg gccttcgcct accgggagct gagccgcctc ggcgacgcgg acttcgacgc     11520
     ggagcaggcg gcccaggtgc tcggcacgga cctgctggag gccgaggacc tgatcgagac     11580
     cctggtcgac gcgcagctcc tggaggcggt cggccgcagc cgctggggcg ggatgcgctt     11640
     taagtggcag gagctggtac ggctgcacgc gtcccactgc ctgacggccg cggggtccct     11700
     ggagaccccg gccccggtcg ccgtggccct caccgactga gccgggaacg gcgacggccc     11760
     gtacgccccc tgccggggac gtacgggccg tcgtggtccg gtcagttgcc ggtgctcatc     11820
     gcctccacga ggctcctggg ccgcatgtcg gtccagttct tctccacgta ctccaggcac     11880
     gcctcccggt cggactcgcc gagggcgacc gtccacccgg cgggcacgtc cacgaaggac     11940
     ggccacagcg agtgctgccc ctcatcgttg accagcacga gatagcggcc gtctgcgtct     12000
     tcgaacggat tggtcacgtc gcattccttc cgggagcgtc gggctggaga ctctgcgcgg     12060
     gtcgcggacc ctgccgaccc cggtcaaggt actgagaccg tctttccttc cgatatcgat     12120
     ccgttttccc acgggccgct cagcgtccgt gggtgacgac ctccgggtcc tgccgggcgg     12180
     cggtgtcgag gcgtggcccg taccgccgca gccgttcgtc gaggaaggcc accaccagct     12240
     ccctggtgac gcgcccggcg tcggccgcgc cgagcgtgac ctcctcgccc gccgtgccgg     12300
     tgcgttcgag gagccgggcg tagtcggtga aggacaggtg cccggcgccc cgcaccgaca     12360
     gccagcggcg cggccccgac aggtcccgcc aggcccgctg ccaggtgggg tcggcgccgg     12420
     gccggccgtg ttcgccggcg ccgagcagca ggaacggccg gtccaccggg ctcctgccgc     12480
     cggtgtggac ggtgccgtcc aggttggccg cggcggcgaa gccggcgtcg gtgcgcagcg     12540
     cctcgaaggc ggcggcgccg cccatcgagt ggcccaccac cgccacccgc gacgggtcga     12600
     gccgcggcag ccccacggcg cccggcgacc gcagcagccg ctcgcgcacg aagcggaggt     12660
     ccgcggcgcg ggtggcggcg acccgtgcgc cctccgggtg ccgtcggcag gccaggcagc     12720
     cggtcacgcg gccgtcgggg tggctgatgg ccggggcctc gtaggcgtgg tcgaccgcgg     12780
     cgacggcgta cccgcggctc gccagctcct cggcgagccc ggtcagcgac gagcggggca     12840
     gcgcgaagcc cggcgagagc aggacgaggg gcagcccgcg ggcgggcgcg ggcagcggcg     12900
     gcggggccgt gcgcgcgtgg acgcggaaac gggcgagcag gtcggcgggc acgccctcga     12960
     cccggtggaa gcgcaggatc agcgccgact cccgggccgt gacgtacgag gcgcgcggcg     13020
     cccgcgaggg cagcgccggg taccagagcg agagggccag ctcgcggtac cggtcggggt     13080
     tccaggggtc gcgccgggag gtgtcgcgca ggtgcgcggt gcgcacgccg accggcaggg     13140
     cgccggtcgg cgcgggcacg gcggacgcgg tccacgcggc gtcggcggcc ggcgcggccc     13200
     gcgcggctgc cgtgccgggg gcgcccgcgc cgaagggcac gagggccagc agcagggccg     13260
     ccacgagggt ggcacaccgg cgcgccggac gaccggcttc cctcacgttc ggcatcagcg     13320
     ctcacttcgt cggaagcagg aacaccgatc acgctaggag cgggaagcac gaggtgaaag     13380
     cggcaacggc ggtttcatca ccttggtcgc cacaagtgga tgcgatcttc gtgggccggc     13440
     cggtgaagcg cctggacttc cgtcgtccgc ccgcacgccc ggccctgtcc tttcgacagg     13500
     gccgggcgtg cgggcgggag cgtcacatga agaccatcgt gagatgggtg tccgccacgc     13560
     ccgtgacatc cttggggccg tactccgact cggtcgggtc gtagtcgaac tcgacgtagg     13620
     gcttgtcggt gaagtgcggg caggccaggg tgctggtgct ggagtcgggt ccggacgccg     13680
     tctcccagtc gatccaccag cccacgcagc cggagtcgcc tccgttgaag gggccgccgg     13740
     gcttgaggtc ctcgacgtgg ccggtcaccc gtacctcgcc gtcctcgacg cagacggtga     13800
     tctcgccccg gccgaagtcc tcggtctcgc tgtccgtgac acagccggag gccgcgggcc     13860
     cggcgggcgc ggcggaggcg gccgtcgtcg ggagcagggc gaccgcgccg atcgccgcgg     13920
     tgagcgccgt ggcgcgcagg attccacgca tggtcgtgtc ctttccatcg gtggtgccgg     13980
     atgacggtgg tggcgcgggt cctcgggatg ccggggccgc ggcggtccgt cgcccccggg     14040
     gggtcaggac gagggagtgt gcggctcccg gatgcgggcg cgtccggcca cgccgaagcg     14100
     cagggtctcc cgcagccgga ccgggccgtc ggtgtcgccg gaccgcgcgg cgtccctcag     14160
     ttcgcgggcc atcgcctgcg cctcggccgc ccagtcgtcc aactggtcgg cgacgggacc     14220
     ggcgttggcg gtcaggatgc gggcccagcg ttccgggttg gcgtccgcgg tcctggtgac     14280
     gtcccgcagg tcctggccgg ccagccgtac ggccgactcg tcgccgccga gcagccgcgc     14340
     ggcgaccagg ctcgcgacca ggtgcggggc gtgcgagacg agggccacgg cgcggtcgtg     14400
     ggtctcgggg tccagcagca ccgagaccgc cccgcacagc gcgaccagtt ccagcgcgca     14460
     gttcagggcg aggttcccgg tggcctcggt gggcgtgagc gcccagggcc tgccgtcgaa     14520
     gaggtcggcg cgggcctgga cggggccgct gccgccgacc acgggggcgc cgctgaccag     14580
     ggaggtcagg tcgcagccgt gcgccctgac ctcccggtgc agacgcacct tgacgccgga     14640
     gacgtcggtg tagcagcggg ccgtgccgag cttctggtgc tcggcgagca ccggcgcgac     14700
     ctggtcgggc ggcaccgcga gcaccgcgat gtcggcctgt cgcggcggcg gcgccgcgaa     14760
     gccggccccg cagcgttcgc ccgccagcgc cgcctcgggg tcggcgtcgg tcaggtacgt     14820
     ggtcacgccg tgccgccgca gggcgagccc gacggagcgg ccgatcacac cggcgcccac     14880
     gatgacgacg ctgcgcatgc gtcttcccct cctcggcccg gggcccgcgc tgcctgctcc     14940
     gccctgctcg gctcggcagg ctcgttcggc tcggctcggc tcagctcggc tcggctcagc     15000
     cgaagatctt gacggcctgg tagtaggtcc aggcggtgct gttgcaggcc gtgttcttct     15060
     cgccggtgta gccggtgcag acgcgcttca tgtcctcgta gaaggcgctg tcgatacggc     15120
     tcttgttggc gtcgaagctg cccgccgcct tgtagttgcg gtaaccgaag tcgtggcgcg     15180
     cgcaggccgt gttgaacggg aagccgaagg ggttgtcggg cgcctgggtg cacaggtccg     15240
     tggaccagtc gaactcgtag gcggcccagg cggactggtt ccggttggcc gcgagccagg     15300
     cgttctggct ggacgcgctg gtctgcgtga aggaggcgag tacctggggc ttgtccgcgg     15360
     gggccgcctg ggcgggcgcg gcggcgacgc cgagggcgag cgccgcaccg acggcggcga     15420
     gcgtggtccg ggtcctggtg gtggtgcgca cgggcggcct ccaaggtggg gggcggatac     15480
     ggctccacca ccttggctgg gcccgctatg ggccccttat cgcaccggta tcgacgaagg     15540
     ggccgtgctc cggcagccgg agcacggccc ccggctcccc ctggggagcc cggacgagtg     15600
     gcgggtcagg cgtcgcggcg gcgcagcacc gcggtgccgg cggcgtaggc ggccagggcc     15660
     cacagcagga ggaccagcag tgcggtgccg gcgccgtagg ggtcgctgtc ctgggtcagc     15720
     aggacggtac cggcgacgct cggcatgtag tccgaggcgg tctccagcca cttggcgccg     15780
     acgacgccca tcagctgggg cagcgcgagc aggaccatga tgagggtggt gatggtgccc     15840
     gcggcgctgc gcaggacggt gccgagcccg atggccatga cggcgaggag ggcgaggtag     15900
     accccggcgc cgagcgcggt gccgaacagc tggccgctgc tgtagtcgcc gtagtcgccc     15960
     atcaggggcg cggccaccag ggtgcccagc aggctgaaga cgaagcccga cgcgaccacg     16020
     acggcggcga cgaccagggt cttggagcgc agcatccggc cgcgcgcggg cacgctctgc     16080
     aacgtggtgc ggatcgagcc gctggagtac tcgctggtga gggcgagggt ggcgaggacc     16140
     acgatggtca gctgggagat gaggaaggcc tgcgaggcgt ggtgcggggc gggcatcgtg     16200
     acgtcgacgc ccttcttcgc gctggcgtcg gcggaggcgc cgaccatggc ggcgaaggcc     16260
     acggtgagca gcaggccgac ggccaggttc caccaggtgg cccgcacgct ccagaacttg     16320
     gtccactcga aggcgacggc gcccttgaag ccgccgccct tcacgggacc cacgagcttg     16380
     gggacggttg tagtagtcat atccagttac gccttctggt ggtccgggac ttcggtgacc     16440
     tgggagagcg cgggagagcc gtactccacg ctcgcggcgg tgagttccat gtacgcctgt     16500
     tccaggctgg ccttgcgcat gctgagttcg tggatcggaa cgcggtggtg gaaggcgagg     16560
     tcgccgatct cctccagggt tccgccgacg acgaggagtt cgtcgggcgc ggagtccgcg     16620
     ttcggctcga cgcgcagtcc gaactccagc agctcccgcc tgagcacgtc gggctgcggg     16680
     gtccgcaccc gtacggcggt cagcgagctg cccgcgatga cctcctcgat cggcgcatcg     16740
     gcgatgatct ttccgcgccc gatgaccagg aggtggtcgg cggtctcctg catctcgctc     16800
     atcaggtgac tggacacgaa gatcgtcctg ccctccgccg cgagggaacg catcagctcg     16860
     cggacccagc ggacaccgtc cgggtccagt ccgttgaccg gttcgtcgaa gagcagcacc     16920
     ttggggtcgc ccagcagggc ggcggcgatc ccgagccgct ggcccatgcc gagggagaag     16980
     gagccgatgc gcttgttcgc cacctcggac aggcccacgg tctgaaggac ctcgccgacc     17040
     cgggacgccg ggatcccgtt gctgcgggcc agcccgagca ggtggtgccg ggccgaacgg     17100
     ccggggtggc ccgcgcgggc gtcgagcagc gcaccgacct cgcgcaacgg gtgccgcagc     17160
     tcctcgtaac gcttgccgcc caccagggcc cgccccgagg tgggcgcgtc cagaccgacg     17220
     atcatgcgca tcgtcgtcga ctttcccgcg ccgttcgggc cgaggaatcc ggtgaccttt     17280
     cccggattga tctcgaacga gaggtccgag acggccgtct tgtcgccgta ccgcttggtc     17340
     agtcggtcca aagtgatcat cgcctggtgg ctccttccaa agtcacgtcc tcaacgctag     17400
     ggagaggcag gggcacgaaa catctggcga tcggcaacga ccgcagtcga ctttcggcag     17460
     atccggcggc cggggccgct cttgtagcgt gctggaatgc accgatggca ggccgtgcgc     17520
     cgacgaatcg aatcgcttgt acgggtcctc ggctccgagc gcccgttcac ccggcgcgcc     17580
     gatctggtgc tgctgctcgt actgctcgtg ccctccgcgt tcgccaccgg gacgctcgag     17640
     accgcgccgg tcgcctggct gaccgcgtgt ctgctcatcg cggccgcggt cgtggtgcag     17700
     cgcaccgcgc cgctgctgtc cctgctgctc gcggcgctgc tcacgctgtt ctatccgtgg     17760
     ttcggggcga acctgtggcc gtcgatggcg acggtggtgc tgagctgcct cgcgggccgc     17820
     agactgaccc ggctgtggcc cgcgcacctg gtgttcctct gtgtcgccgc ggccgggctc     17880
     ctgctggtgg ccaccgtcgg ccagggcaag gactggctga gcctgctgat gaccgagttc     17940
     gtcgcctgtg tgctgccctg gtgggcgggc aactggtgga gccagcgcac cgcgctgacc     18000
     cacgccggct gggagcacgc cgagcaactg gagtggcgcc agcgctacat cgccgaccag     18060
     gccaggatga aggagcgggc caggatcgcg caggacatcc acgactccct gggccacgaa     18120
     ctgagcgtga tggccctgct cgccggcggc ctggagctgg cccccgggct gtcggacccg     18180
     caccgggagt cggtgggcca gttgcgggag cggtgcacga tggccaccga gcggctgcac     18240
     gaggtgatcg ggctgctgcg ggaggacccc aatccgtcgc tgacccccgc cgacgagtcc     18300
     gtcgcccagc tcgtgcgccg tttccagcgc tccggtacgc cggtccggtt ccaggaggac     18360
     ggggcccggg accgccccgg cacgccgctg ctgtccgacc tcgcggccta ccgggtggtg     18420
     caggaggcgc tgacgaacgc ggccaagcac gcgccgggcg cgcccatcga cgtacgggtg     18480
     acgcacaccg cggacgagac ggtggtgtcg gtcgtcaacg agcggccgga gcggggcggg     18540
     agtgttccgg cggccgggag cgggtcgggg ctgatcggcc tcgacgagcg ggtccggctc     18600
     gcgggcggca cgctgcgcac gggcccgcgg gcgggcggtt tcgaggtgta cgcgcgactg     18660
     ccgcgcggcg cctcctcgcc gtcgcggtcc accgagccgc cggggccggc cgacggggac     18720
     ggcacggccg gtggctcggg cgacggcacg gcgcccgggg ccgcgacggc cggcaacgag     18780
     gggcgggccg cggccgccgc ggcggacctg cccgccccct ccgggccgtg gcgcagcgcc     18840
     tcccgggccg cgctgctgcg cacccgggcc cggatcaggc gggacgcccg gcgggccgcg     18900
     ctgatacccg cggtgctcgg cgccgccatc gtggccttcc tcggcgggct ctacgtcttc     18960
     acctcggcga ccacgtccct cgcccccgag gactacgccc ggatccgggt gggcgagacc     19020
     cgcgccgatc tggcgcccgc gctgccggag cgccggatca agaagccgcc gccggtcacc     19080
     tccgagccgt ccgtcccggc cggcacgacc tgcgagtact accgggcgag cagcggtctg     19140
     ctcgacttcg gcggcgccat gtaccggctg tgcttcaagg atgatgtcct catggccaag     19200
     gacacgctct gaccaccagg gaaggatcgg atgattcgcg tactgctcgc cgacgacgag     19260
     accatcatca gggccggggt tcgctccatc ctgacgaccg aaccgggcat cgaggtggtc     19320
     gccgaggcgt ccgacgggcg ggaggcggtg gaactggccc gcaagcaccg gcccgacgtg     19380
     gccctgctcg acatccggat gccggagatg gacggcctga cggccgcggg tgagatgcgg     19440
     accaccaacc cggacaccgc ggtcgtcgtc ctcaccacct tcggggagga ccggtacatc     19500
     gaacgggccc tggaccaggg cgtggccggg ttcctgctca aggcgtccga tccgcgggac     19560
     ctgatctccg gcgtacgggc cgtggcgtcc ggcggctcct gcctctcccc gctggtggcg     19620
     cggcggctga tgaccgagct gcgccgggcc ccctcaccgc gctcggaggt gtcgggggag     19680
     cgcacgacgc tgctgaccaa gcgggagcag gaggtcctcg gcatgctggg ggccgggctg     19740
     tcgaacgcgg agatcgcgca gcggctgcac ctggtcgagg gcacgatcaa gacgtatgtc     19800
     agcgccatct tcacccagtt ggaggtccgc aaccgggtgc aggcggcgat catcgcgtac     19860
     gaggcgggac tggtgaagga cgccgacctc aaccgttaga cgccgcgcgg tccttgacga     19920
     agcgggccag ccgcgtcgcc ccctcggcgg cgcggtcggt ggtgaggtag ctgcacgaga     19980
     ggcggatctg ccggtcgccc gcgtcgtcca ggtggaagtg gcgcatcggg gtccagatga     20040
     cgccgtactt ctccgcggag acgtccagcg cggcctcgtc cgcctcgaag ggcacgtcga     20100
     gggtcaggaa gaacccgccg tccgggtcgt tccaccgcac gccgcccgat tccggtgcgc     20160
     cgggcggcag ttcggcggcg agggtgtcgc gcaggcaccg catcgtggac tggtagtggc     20220
     gggccgaggc ctcgttcgcc gcccgcagtc ccccgccgtt ctgcagcagc agtccggcga     20280
     ccgcggcctg gctcagggtg ggggtgttga cggtgaccat gctcttgacc ttggccagtt     20340
     cgtgggcgag cagaccgggc ggccgcccgt ccgcgccggc cacgagctgg tcggcgacga     20400
     cgaagccgac gcgggcgccc gggaaggccg tcttcgcgaa ggaaccgagg tagacgacgc     20460
     gccgttcggt gtcgagggac ttgagggtgg ggcggcgcac ccggctgaac accccgtagg     20520
     gattgtcctc caggaggagc aggtccagcc gcgcggcggc gtcgagcagg gcggtgcggg     20580
     cctcgcggcg caagctgacg ccggtcgggt tggagcagtc gggcaccacg tacaggcacc     20640
     tggcgcgccg gccgctcgcc tcgatctccc ggacggtgcg ctccagccct tccgggctcg     20700
     gcccgtcggg ggtgccgggc accggcacga cggggatgtc cagcaggccg gccgcgccgg     20760
     tgatgccgac gtaggcggga ctgtcgacga ggagcacgtc ctccggaccg gtgaacaggg     20820
     cgcgcagggt gagcaggacg gcctcctggc agccgaccgt caccaccacg gaggcggggt     20880
     cgaccgtcag gtcctcgtcc acctcgagca tgcgggcgac gatgtccctg atctgcccgg     20940
     cggtctcgcc gtactggtag agcgcggtgc ggacgcgctc ctcggagtgg ccgcgcccgc     21000
     gcaggtggtc gaggtaggtc tcgatgtacc cggggacgcg tgcgacgtcg aagtctccct     21060
     cgtaggggcg tcccggggcg aaggagatcg cctgcgggta gcggagggtc acctcgttga     21120
     ggaagttcat cgtgtcgagc agcggggcgg acaggctggg gtgcagggcg gtccgcgcca     21180
     ggacgccgtc ccggtccgtg cgcgctgggg tggtggtggt catccgtggc tcctgtctcg     21240
     gtgcggcgcc gggcggggcg cggtgggcgg cccgtggtgc ggcggggcgt ggtgcggcgg     21300
     ggccagggtg tccgggccga tcgtgccggt ggcggcgtgg ccggtgagca ccatcgtgtc     21360
     cgcgaagtcc tcggtcagca gggtgagcat ccggcgcacg cccgaggcgc cgccgaccgc     21420
     cagcgcgtac agcgcggggc gcccgaccag gacggcacgg gcaccgaggg ccagggcggc     21480
     gaggacgtcg gcgccggtgc ggacgccgcc gtcgaggagg accgggcagc gtccgcgcac     21540
     ggcggacacc acctcgggca gcgcctccag ggtggccggt gcgccgtcga gttggcggcc     21600
     cccgtggttg gagacgacga tgcccgcgac gcccgccgcg accgcggcct cggcgtccgg     21660
     cgcggtcagc acgcccttgg ccagcaccgg caggccgctc gccgcgccca ggcgggccac     21720
     gaaggaccag tccaggcggc ggtcgaaggc cagcctgctg tgcgcgccgg gggtggcgct     21780
     gccggccgcc gccgtgccgg tcaggttggc cggggtgatg tgggcgggga ccgcgaagcc     21840
     gttgcgcagg tcgcgcagcc ggcggccggt gaacggggtg tcgacggtga gcaccagcgc     21900
     ctggtagccg ctgtcgcggg ccctgcgggc caggcccagg gtggtctcgt ggtcgcggaa     21960
     gcagtacagc tggagccaca gcggtgcgct cgccgcgcgg gccacctctt cgaggctccg     22020
     gccggcgaag gtgctgacga cgagcgggag tccgagcgcg cccgccgccg cggcggtcgc     22080
     cggttcgccg tcggggtggg cgagcccgtg gtaggccacc ggcgcgatgc ccacgggcgc     22140
     cggccaccgg gagccgagca cctccacgga ggtgtccggc tcctcgatgc cgggcagtgc     22200
     cctgggccgc agccgtacgg ctccgaagac ggcctcgttg gcggcgaggg tccgctcccg     22260
     ccccgcgccg cccgcaatga agtcccaggt ggcggcaggc agttgcccgc gtgcgagtcg     22320
     tgcgaagtcg tcgagcgtga gcggctcccg caccccggcg ccggcgccgc ccgccgcgct     22380
     cccggccgcc actggcgccg gggccccgga cccgccgggt gccgccggtg ccgtgccccc     22440
     ggacccgccg cggtccgccg gtgccgggtc ttcggggtcc gccgggtgcc ggacggcgga     22500
     ggtcatcggc cggccacttc ccgctcccgc tcgacggcct cgtacagggc cttgatgttg     22560
     gaactgccga agccgcgggc gccgttgcgc tggatgtact cgtagaagag ggtgccgcgc     22620
     gggtagggcg agcgggtgaa gatctgcagc aggtagcccc actcgtcgcg gtccgcgagg     22680
     acgttggtct cgcgcaggtc ctcgatggcg tcggccatcg cgccgacccg ctcggtgagc     22740
     aggtcgtagt aggcgcccgg ggtgcgcagg aaggccacgc cgcggtcgcc gagcgagcgg     22800
     accgagccga cgatgtcgtc caccaggaag gccaggtgct ggacgcccgg cccgtcgtgg     22860
     gcgctcagga actggtcgat ctggcccggc acccgggtgt cgtccggttc gatgagcgtg     22920
     aaggtgatgc cgccgccggc gttgcgcacg acgatggagt ccatcgcctg ctcgcccacc     22980
     tcgatgtact cggaggagta gtagggcatg tcgaaggccg cttcgtagaa ctcggcggtg     23040
     ctccgcagcg tgccggactc caggcagacg gcgacgtggt cgaggagggg ccgcggcccc     23100
     gtgcggccgg tggcggccgg gagcagcgcc cagtcccggt cgggcggcag cagccccgcg     23160
     ccgtccccgt ccgccgccgg gaccagggtg tgccggatgt ccccgaagcc ggagacggtg     23220
     gcgaaccacg cgtcctggcc cgcccggtgg gagggcgtcg gggcctgaag cgcctcggca     23280
     ccggcgagga ccgcgcggtc gaagcaggag cgcacgtcgt cgcagccgaa ggcgaggtcg     23340
     gcgatggagt cgccgtgccg ctccacgtac cgggcgaccg gggtgtccgg cgccagcgcc     23400
     tgggtgacca cgagcgtgac ctcgccgctg cgcagcaccg tggaccggcg gtcgtgggtg     23460
     ccggtggcgg ggcccgccac cgccaggggg acgaaaccga ggctgtcgac gaggaagccg     23520
     gaggcctccc ggtcgtccgc gacgtacagc tcggcgtacg cgatgtcact gggcggcatg     23580
     gcggctctcc aatgaaggaa ggggaaagga gggagcactg agggagcgcc cgccggggag     23640
     agggaagggg gccctctctt tctccggcag caatgagaaa tgcacgttgc cacactctac     23700
     aaatgacccg tataacctcg ctatcgactg gttatcaagg ctcctacctg cggttatctt     23760
     ccctaataag catattgacc agctcgtcgc ggccttgcta gcgtcccagt tcgccctcaa     23820
     tttaatgccg tccggtaaat gccgcacggg cacacatctt gttcgttttg cattgtgagg     23880
     agacaggtgt ctgagaactc ttcggttcgg cacggtctga cgagcgcgca gcacgaggtg     23940
     tggctcgccc agcagctgga tccgcgtggc gcgcactacc ggacgggatc ctgcctggag     24000
     atcgacggac ccctggacca cgcggtgctg agccgcgccc tgcggctcac cgtggccggt     24060
     acggagacgc tctgctcgcg cttcctcacc gacgaggagg gccggccgta ccgcgcgtac     24120
     tgcccgcccg cgccggaggg ttcggccgcc gtcgaggacc cggacggggt gccgtacacc     24180
     cccgtgctgc tgcgccacat cgacctctcc ggtcacgagg accccgaggg cgaggcccag     24240
     cggtggatgg accgggaccg cgcgacgccg ctgccgctgg accggcccgg cctgagcagc     24300
     cacgcgctgt tcacgctcgg cgggggccgg cacctgtact acctgggcgt ccaccacatc     24360
     gtgatcgacg gcaccagcat ggccctgttc tacgagcggc tggccgaggt gtaccgcgcg     24420
     ctgcgggacg ggcgtgcggt gcccgcggcc gccttcgggg acacggaccg gatggtcgcg     24480
     ggcgaggagg cctaccgcgc gtcggcgcgg tacgagcgtg accgggccta ctggaccggc     24540
     ctgttcaccg accgccccga gcccgtctcg ctcaccgggc gcggcggcgg ccgggccctc     24600
     gcgccgaccg tgaggagcct gggcctgccc ccggagcgca cggaggtgct cggccgggcc     24660
     gccgaggcga ccggtgcgca ctgggcgcgc gtggtcatcg ccggtgtggc cgccttcctg     24720
     caccggacga cgggcgcccg ggacgtcgtg gtgtcggtgc cggtcaccgg gcgctacggc     24780
     gcgaacgccc ggatcacccc cggcatggtc tccaaccggc tgccgctgcg gctggcggtg     24840
     cgccccggcg agagtttcgc gcgggtggtc gagaccgtgt ccgaggcgat gagcggcctc     24900
     ctggcgcaca gccgcttccg cggcgaggac ctcgaccggg agctgggcgg cgcgggggtg     24960
     tcggggccca ccgtcaacgt catgccgtac atcaggccgg tggacttcgg cggtccggtc     25020
     ggcctgatgc gcagcatcag ttcgggtccg accaccgatc tgaacatcgt gctgaccggc     25080
     acccccgagt ccggcctgcg cgtcgacttc gagggcaacc cgcaggtgta cggcggccag     25140
     gacctgacgg tgctgcagga acgcttcgtc cggttcctgg cggagctggc ggccgacccc     25200
     gcagccaccg tcgacgaggt cgcgctgctg acgccggacg agcgggagcg ggtcctcgac     25260
     gggtggaacg acaccgccca cgaggtcccg gagaccacgc tgcccgagct gttcgccgcg     25320
     cgggccgcgc gcacgcccgg gcacgaggcc ctggtctacg agggcacctc gctgacgtac     25380
     gccgaactgg acgcccgcgc cgagcggctg gccggtgcgc tgacggcgcg gggcgcgggc     25440
     ccggagcggt tcgtcgcggt cgccgtggag cggtccgcgg agctggtggt ggcgctgctc     25500
     gcggtgctca agtcgggcgc ggcgtacgta cccgtggacc ccggctaccc ggccgaccgc     25560
     atcgcgcaca tcctgcggga cgcgggcgcg atgctggtgc tgaccacccg ggacacggcg     25620
     gagcggctgc ccggggacgg cacgccgcgg ctgctgctcg acgagccggc cgcggcgggg     25680
     accaccgcgg cgggggcacc cgccccgccc ggcaccctcc cgcgggcgct gcccgctccc     25740
     ggccaccccg cctacgtcat ctacacctcg gggtccaccg gccgccccaa gggcgtggtg     25800
     atctcccacc gggcgatcgt caaccggctg gcctggatgc aggacaccta cggcctggag     25860
     ccgtccgacc gggtgctgca gaagacgccg tccggtttcg acgtgtccgt gtgggagttc     25920
     ttctggccgc tcgtccaggg cgccaccctg gtcgtggccc ggcccggggg ccacactgac     25980
     ccggcctacc tggccggcac cgtccggcgc gagggcgtga ccaccctgca cttcgtgccg     26040
     tcgatgctcg acgtgttcct gcgggagccc gccgcggccg cgctgggcgg tgcgacgccg     26100
     gtgcggcggg tgttctgcag cggcgaggcg ctcccggcgg agctgcgggc ccgtttccgg     26160
     gccgtgtcgg acgtgcccct gcacaacctg tacgggccca ccgaggccgc cgtcgacgtg     26220
     acgtactggc cgtgcgccga ggacaccggc gacgggccgg tgccgatcgg acggccggtg     26280
     tggaacaccc ggatgtacgt gctcgacgcc gcgctgcggc cggtcccggc cggggtgccc     26340
     ggcgagctgt acatcgccgg tgtgcagctc gcccgcggct acctgggccg ccccgcgctg     26400
     agcgccgaac gcttcaccgc cgacccgcac ggcgcgcccg gcagccggat gtaccgcacc     26460
     ggcgacctgg cgcgctggaa ccacgacggc agcctcgact acctcgggcg cgccgaccac     26520
     caggtcaagc tgcgcggctt ccgcatcgaa ctcggcgaga tcgaggccgc gctcgtacgg     26580
     cagccggaga tcgcccaggc cgccgtcgtc ctgcgcgagg accgccccgg cgaccagcgc     26640
     ctggtcgcct acaccgtgcc ggctcgggac gcggacacgc tcacgggccc gcctgcggag     26700
     gcggggacgc accccgggcc gggcgccgca ccggacacag acccggccac cgggcccgcc     26760
     gccgggacgg actccggccc ggggtccgga acggggtccg gaacggggtc cggaacgggg     26820
     tccggagcgc gccccggacc ggacggcacg gcgacgcaca ccgttgccgg cgccggaccg     26880
     gccgcggccg gggaaaccgc cgccggggcg gacgccggga ccgggaccgg ggaaaccggc     26940
     gccggggcgg acgccgggac cgggaccggg gcacacgccg gcccggacgg tgccgtgctc     27000
     gccgcgcggc tgcgggagtt gctgcccggg tacatggtgc cctcggcctt cgtcgcgctg     27060
     ccccggctgc ccgtcacacc gaacggcaag ctggaccggc gggccctgcc cgcccccgcg     27120
     gagtccgggc gcgccgccgg gcgggcgccg cgcacgccgg gcgaggagct gctgtgcgcg     27180
     ctcttcgccg aggtgctcgg cgtggccgag gtcagggtcg acgacggctt cttcgacctg     27240
     ggcggccact cgctgctcgc cacccggctg atcagccgca tccgcgccac cgccggggcg     27300
     gaggtgccga tccggcgcgt cttcgaggcg ccgaccgtgg cggagctggc cccggcgctg     27360
     acggacggcg ggcgggcccg tgccgcggtc accgcccggc cgcgccccga ccgcctgccg     27420
     ctctccttcg cgcagcggcg cctgtggttc atccaccagt acgaggggcc ctcgccgctc     27480
     tacaacatcc cggccgcgct gcggctgacg ggcccggtgg acggcgccgc cctgtcggcg     27540
     gccctcggcg acgtggtggc ccggcacgag agcctgcgca ccgtcttcgc cgaggacgcg     27600
     cacggccccc accaggtgat cctgtccgcc gagcgggccg cgccccggct caagacgctg     27660
     gacagcgacc cggagcggct ggccgccgac ctcgcgcgca ccgcccggca caccttcgac     27720
     ctgacccggg acgtaccgct gcgggccacc ctgctgcggg tggcgcccga ggagcacgtg     27780
     ctgctcctcg tcctgcacca catcgcgggc gacggctggt cgctggcgcc cctcgcccgg     27840
     gacctgggca ccgcctacgc cgcccggacc gccggcacgg cccccgactg ggcgccgctg     27900
     ccggtgcagt acgccgacta cacgctgtgg cagcgtgaac tgctcggcgc cgacgggaac     27960
     ggcgcgggca ccggggacgg cggtgagggc gcccggcagc tcgcccactg gcgcgaggcg     28020
     ctggccgggc tgccggagcg gctggagctg ccgagcgacc ggccgcgacc ggcgcgccgc     28080
     gacaactccg gcgcgcgcct ggacgtgtcc gtgcccgccg ggctgcaccg ctcgctggcc     28140
     gcgctcgccg ccgagacgcg gaccagcgtc ttcatggtgc tccaggccgc gctggcgggg     28200
     ctgctgaccc ggctcggcgc gggcgaggac gtgcccatcg gctcgaccat cgcgggccgc     28260
     accgacgccg ccgtcgagaa cctggtcggc ttcttcgtca acacgctggt gctgcgcacc     28320
     gacaccggcg gcgacccggc cttccgcgag ctgctctccc gcgtccgcga gcgcgacctg     28380
     gccgcctacg cccaccagga cgtgcccttc gagcggctcg tcgaggcggt caacccggac     28440
     cgggccacct cccaccaccc gctgttccag gtgatgctga ccttcgacac cacccagcag     28500
     gacgccctcg gcgagctggg ccggctgccc gggatcacga cctcgctgct gcccgtgcac     28560
     accgggctgt cccggttcga cctcgtgttc gccttcgacg agcggcggga cgccgcgggc     28620
     gggcaggccg gtctcgacct cgcggtggag ttcagcaccg agctgttcga cgccggcacc     28680
     gtgcgcgccc tcaccgagcg gctgctgcta ctgctcacgc aggtcgccgc cgatcccggc     28740
     gtgcgcctgg gcgacctcga cgtcctcctc cccggcgagc accacgacct gctggtggcc     28800
     gccaaccggc ccggcaccgc gcccgcttca ccggcacccg cttcaccgga gcccgcgtca     28860
     ccggagcccg cgtcccccgc gccggggacg gccacgctcc ccgagctgtt cgagcggcag     28920
     gccgcccggc accccgaccg caccgcgctg accttcgagg gcacctcgct gtcctacgcc     28980
     gagctgaacg cgcgcgccaa ccgcctggcc cggctgctga ccgcccgcgg gatcggcccc     29040
     gacgcgctgg tcgccctggc cctgccccgc tccgccgaac tggtcgtggc cctgctcgcg     29100
     gtggtcaagt cgggcgccgc ctacgtgccg ctcgacccgg gataccccgc cgaccggctc     29160
     gcccacgcgc tgtccgactc cgcgcccgcg gccctgctca ccgaccgcgc caccgccggc     29220
     cggctgcccg cccacgaggt gccccgcatc gtcctcgacg cccccgcccc ggcggacggc     29280
     ggcaccacgg gcggcgaccc ggcggacgcc caccccgcca ccgacctggc gcagggcgag     29340
     cgggtcagac cgctggaccc gagggacacg gcgtacgtca tctacacctc cggctcgacg     29400
     ggccgcccca agggcgtggc cgtgccgcac ggcaacgtcg tacggctctt ctccgccacc     29460
     gcgccctggt tcggcttcga cgagcacgac gtgtggacgc tcttccactc gtacgccttc     29520
     gacttctcgg tgtgggagct gtggggtccg ctgctgcacg gcggccggct cgtcgtcgtc     29580
     ccgcacgacg tcacccggga ccccgccgcc ttcctcgccc tgctcgcgcg cgaacgcgtc     29640
     accgtcctca accagacgcc gtccgccttc caccagctgg ccgccgccga ccgtgagaac     29700
     cccaccgaac tcgccctgcg caccgtggtg ttcggcggtg aggccctgga cctgtcccgg     29760
     ctggccgact ggtacgagcg gcacgccgag gacgcgcccg ccctggtcaa catgtacggc     29820
     atcaccgaga ccaccgtcca cgtctcgcac ttcgccctgg accgggccac cgcggccgcc     29880
     tcgtccgcca gcaccatcgg cgtcaacatc cccgacctgc gggtctacgt cctcgacgac     29940
     cggctgcgcc ccaccgctcc cggcgtcacc ggcgagatgt acgtggccgg tgcgggcctc     30000
     gcccgcggct atctgggccg cccggcgctg accgcggacc gcttccccgc cgacccgtac     30060
     gccgccctct tcggcgagcg cggcacccgc atgtaccgca ccggcgacct ggccaggcgc     30120
     cgcaccgacg gcggcctcga ctacctgggc cgcgccgacc agcaggtcaa gatccgcggc     30180
     ttccgcatcg agcccggcga gatcgaggcc gtgctcgccg cccaccccgc cgtcgacgac     30240
     gtggccgtgg tggcgcgcga ggacgtccag ggcgaccccc ggctcgtcgc gtacgtggtg     30300
     accggctccg gcgccacggc ccgcgcgctg cacgaccacg cggccgggca cctgcccgac     30360
     cacatgctgc cgtcggcgtt cgtcaccctg gacgtgctgc cgctgacgcc caacggcaag     30420
     ctcgacacca aggcactgcc cgccccggcc cacgcggggc aggtgaccgg acgcgcgccg     30480
     cgcgggccgc gcgaggagat cctgtgcgcc ctgttcgccg aggtgctcgg ggtgccccgg     30540
     ctgaccgtcg acgacagctt cttcgacctc ggcgggcact ccctgctcgc cacccggctg     30600
     gccggccgca tccgcggcac cctcggcgtg gagctgtccg tgcggcggct gttcgagacc     30660
     cccacggtcg ccgggctgtc cgccgccctc gacggcgccg aacggtccgg caccggcccg     30720
     acggccgggg agcgcccgga gcggctgccg ctgtcgtacg cccagcagcg gctgtggttc     30780
     ctgcaccagc tggagggccc ctcccccacg tacaacatca ccggcgccct gcggctgacc     30840
     ggcgacctcg accccggggc gctgcgcgcg gccttccagg acgtcgtcac gcgccacgag     30900
     agcctgcgga ccgtcttctc ggaggacggg cacggcgccc ggcagaccgt gctcgacgcc     30960
     gccggtgtgc gcttcgagct gccggtcgcc gacgtgagcg aggaccggct ggacgcgcgc     31020
     ctcgaggagg ccgcccggca ctgcttcgac ctgacgaccg acatcccggt gcgggcggag     31080
     ctgttccggc tcggcgcgcg ggagcacgtc ctgctgctga tggtgcacca catcgccggt     31140
     gacggctggt ccctcggccc gctgatccgc gacctggccg ccgcctacac ggcccgcgcg     31200
     gcccgtcgcg cccccgactg ggcgccgctg cccgtgcagt acgcggactt cgccctgtgg     31260
     cagcgcgccg cgctcgggga cgccgccgac gccaccagcc cggcgggccg gcagctcgcg     31320
     cactggaagg aggccctggc cggactgccc gaccggctgg aactgcccgc ggaccggccg     31380
     ctgcccgccg tcgcctcgca ccgcggcggc cgggtgccgc tcaccgtccc cgcgcccctg     31440
     cacagcggtg tcgcggagct ggccagggag tcccgcacca gcgtcttcat ggtgctccag     31500
     gcggcactgg cggcactgct gacccggatg ggcgcgggcg aggacgtacc gctcggcacc     31560
     ccggtggcgg gccgcggcga cgacgccgtc gaccaggtcg tcggcttctt cgtcaacacc     31620
     ctggtcctgc gcaccgacac cggcggcaac cccaccttcc gcgcactcct cgaccgggtc     31680
     cgcgacaccg acctgaccgc ctacgaccac caggacctgc cgttcgagca cctggtggac     31740
     gtcctctccc cgaccaggtc gctctcccac aacccgctgt tccaggtgct gctgagcctg     31800
     gacaccaccc agcaggacgc cctggccgcg ctctccgcca ccggcctcgg cgtgcggctg     31860
     ctgaacgtca ccaccggggt cgccaagctg gacctcgccc tggagatcgc cgagcaccgc     31920
     gacgccgacg gcgcccccgc cgggctggtg ggcgcggccg agtacagcgc ggacctcttc     31980
     gacgagggca ccgtcacgct gctggtggag cggttcctgc ggcttctgga cgcgctggtc     32040
     gcggacccgt cccggcgcat cggcgacgtc gacgtgctcg gcccccggga acgggagcgg     32100
     gtcctgaccg agtggaacga caccccccgc cggccggtgc agggcacctt cgccgaccac     32160
     gtcgcccggc acgccgccga gcgccccggc cacctcgcgg tcgagacggc cggcgccgcg     32220
     gcgcccggcg gcgcgctgac ctacggcgaa ctgaacgagc gcgccaaccg gctggcccgc     32280
     gccctgctcg cgcggggcgc gggcccggag cggttcgtgg cggtcgccct gccccgctcc     32340
     gccgacctgg tcctctcggc gctcgccgcc ttcaaggcgg gcgcggccta cctgcccgtg     32400
     gaccccgcgc accccgccga acggatcacc cacctcgtct cggacgcggc gcccaccctc     32460
     atcgtgacca cgtccgccct ggccgcgagc ctcccggaca ccggcacgcc ggtcctcctg     32520
     ctcgacaccc ccgagaccgc cgcgaccctc gccgcactcc ccggccacga cgtcaccgac     32580
     gccgaccggc cggtaccgct gcgccccgag caccccgcgt acatgatcta cacctcggga     32640
     acgaccggcc gccccaaggg cgtcgtcgtc acccacaccg ggctgcccgg cctcctggac     32700
     atcttcaccc gcgactgcgc ggccggcccg ggcagcagga tcctccagca cctctccccg     32760
     agcttcgacg cctcgttctg ggagctggcg atgggcctgc tcaccggggc caccctggtc     32820
     gtggcgccgc cggagaccac gccgggaccg gagctggccg agctggcgac ccggcacgcg     32880
     gcgacccacc tgagcctgac cacgtccgtc ctcgggctcc tgccgccgga ctcgctgccc     32940
     gacggactga ccctcgtcgt gggcgccgag gccatcccgc ccgagctggt ggagcgctgg     33000
     tcgccgggcc gtacgatgct gaactcctac gggcccaccg agaccaccgt ctgctccacc     33060
     atgagcggcc cgctgtccgg ccccgccgtc ccgcccatcg gctcccccgt cgccaacagc     33120
     gccgtgtacg tgctggacgc ggcgctgcgt ccggtcccgc ccggcgtgcc cggcgagctg     33180
     tacgcggccg gagcgcatct ggcccgcggc taccacgacc gccgggcgct gaccgccgaa     33240
     cggttcgtgg ccaacccctt cggcgagccc ggcagccggc tctaccgcac cggcgacctg     33300
     gtccgctggc ggcccgacgg acagctggag tacctggggc gcgccgacac ccaggtcaag     33360
     atccgcggcc tgcggatcga gcccaccgag atcgaggcgg tcatcaccga acgcccgcac     33420
     ctggcgcggg cggccgtgat cgtacgcgag gaccggcccg gcgaccggcg gctcgtcgcc     33480
     tacgtcgtgc ccgagcccgg cgccaccgtg gacaccgccg aactccgcgc cgcactgcgc     33540
     gagaccctgc ccgaccatat gatcccgacc gcgttcgtgg tgctggacgc gctgccgctg     33600
     accctcaacg gcaagctgga ccgcaaggcg ctgcccgccc ccgactactc cgcccgcacc     33660
     tccggccggg ccgcccgcga cccgcgcgag cggctgctga ccgcactgtt cggcgagatc     33720
     ctcggcgtgg agccggccgg cgtcgacgac ggcttcttcg acctgggcgg ggacagcatc     33780
     ctctccatcc agctcgtcgc ccgcgcccgc gcggcgggcc tggtcctgtc ggtgcgggac     33840
     gtcttcgaac accagacgcc cgcgctgctc gcccggtcgg ccgccgccgc acccgccggg     33900
     gaccgcacgg cgcgggactc cgacgtgccc gccgacggcc cggcgccgcg caccccgatg     33960
     atgggctggt tcgccgctct cggctccgac ctggccgcgt tcaaccagtc gctggtcctg     34020
     cgcgtgcccg ccgccctcga ccccgacacg ctcgacaccg ccctgcgggc cgtgctcgac     34080
     cggcacgacg cgctgcgcat gcgggtggcc gacgactgga ccatcgagat cccgccgccc     34140
     ggctcggtga ccccggccga ctgcctggtc cgcttcgacg ccgtaggcct cgacgaggcc     34200
     gccgtgcgct cggcggtcac cgagcaggca cggacggccc gcgaccggct ggccccggcg     34260
     gacggccgca tgctccaggc cgtctggctc gaccgcggcg ccgaccggga cgggctgctc     34320
     ctcctggtcg ccaaccacct ggtcgtggac ggcgtcacct ggcgcatcct ggtccccgac     34380
     ctggcggccg cctacgcggg cgagaccctc gccccggtgg gcaccccgtg gcggcactgg     34440
     gccctgtccc tctccgacct cgccgggcag ccgcgaaccg aggaggagct ggaccactgg     34500
     cactcggtcc tcggcgacac cccgcacacg ctccgcctgg accccgcgcg ggacacccac     34560
     gcgaccgccg gcgagatcac cgccgaactc gacgcagaca ccaccgaggc cctgctcacc     34620
     tgggtccccg gcgtctgcca cgccacggtc aacgacgtgt tcctgagcac cttcgccctg     34680
     gccgtcgccg ggtggcggcg cgggcgcggc gaggacgccg acgcacccgt cgtgctcgac     34740
     ctggagagcc acggccgcca cgaggaggcg gtcccgggcg tcgaactcag ccgcacggcg     34800
     ggctggttca cgtcgatgta ccccgtccgt ctcgcaccac ccgccggcgc ctccggggac     34860
     ggatcggcgc tccgcgcgct gaaggccgtc aaggagcagc tgcgcaccgt cccgggcgac     34920
     ggcctcggct acggcctgct gcgccacctc aacccccgca cccgggccgc cctcgccgcc     34980
     ctgcccctcc ccgagttcgg cttcaactac ctcggccgga tcggccagga gggcaccgac     35040
     gaggccccct ggaccatcga gggcggcgac gtcgccggta tcgacggtgc catgccgctg     35100
     gcccaccccg tggacgtgaa cgccgtcgcc cgggagaccg ccgacggcac ccggctgcgc     35160
     gcccgctgga cgtactcccg cacagcgctg gagcccgagg acacccagcg gctggccgac     35220
     acctggttcc ggctgctgcg ccgcctcgtc gaggaggccc ggcagcccgg cgcgggcggc     35280
     ctcaccccct ccgacatcgc tcaccccgcc ctcgcccagg acgagatcga ggacctggag     35340
     cacaccgtcc ccggcctcca ggacatcctg cccctcgccc ccctccagga gggcttcctc     35400
     ttcctcaacc tgtacgacga gaacgcccgc gacgtctacg tcggccagct cgccttcgac     35460
     ctggagggct ccttcgacgg cacccgcatg cgcgcggcgg ccggggccct gctgcgccgc     35520
     cacgccaacc tgcgggccgg gttccggcag acggcgaccg gcacgtgggt gcaggtcgtg     35580
     cccgccgagc tcgaaccgga ctggcgggag tgcgacctga ccgaccgcgc cgacgaggcg     35640
     gaacgggacg cggaggccgg gcggctggcg gccggggacc gcgaacgccg cttcgacctc     35700
     accagcccgc cgctgatgcg cttcaccgcg atccggctgt ccgccgaccg cgtccggctg     35760
     gtgatgacca accaccacat cctgctcgac ggctggtcca tgcccctgct ctggcaggaa     35820
     ctgaccgagc tgtacgtctc cggcggcgac cccgtgagcc tccccccggt ccgcccgtac     35880
     cgcgaccacc tggcctggct cggcgcccgc gaccgggacg ccgcccgcga cgcctggcgg     35940
     cggtccctgt ccgggctcga cgaggccacc ctcctcgccc cggacgccgg cccggccgag     36000
     gcggcaccgc tgggcatccc gttcggcctg gaccgtgacg ccacggcggc cctgtccgcg     36060
     tgggcgcggg gtcggggggt gaccatgaac acggtggtcc agggtgcctg ggccctcgcg     36120
     ctggcccagg ccaccggacg cgacgacgtc gtcttcggcg ccaccgtctc cggccgcccg     36180
     cccgagctgc ccggcgtcga gtccatgatc ggcctgttca tcaacaccct gcccgtccgc     36240
     gcccgcctcg accaggccga acccctcggc gacctcttcc gccgcctcca gaacgaacag     36300
     gcccgcctcc tggaccacca gtggcccgga ctcgccgaca tccagcactg ggccggacac     36360
     ggcgaactct tcgacaccgc catggtcttc cagaactacc cggtgagcgc cgacacgacg     36420
     agccgacagc tcgacggact gcgggtggcc ggttacgacg cggtcgagag caccgacttc     36480
     gccgtcaacc tcgtcgccca cacccgcgac gacgccctgc ggctgcgcct cgactaccgc     36540
     gcggacgcct gcgccggcga cctggtccgc tcactggcgg accggatgct gcgggtcctg     36600
     gaagcactgg tcaccgactc ggaccgtccc gtggcccacc tggacaccct cgacccggcc     36660
     gtacgggagc gggtcctggt ggagtggaac ggggccccga cccagcttcc cgggacaccg     36720
     ctgcacgaac tgatcagcga gcaggcccgg ttgacgccgg acgccgtggc ggtggtgtgc     36780
     gacgggacct ccctgaccta cgccgagctg gacgggggcg ccaaccagct cgcccggcac     36840
     ctgctgggag aaggcctcgg tgcggaggac ttcgtcgcga tcgccctggc caagtcgctg     36900
     gacgcggtga tcagcatgct ggccgtgctc aagaccggcg cggcctacct gcccatcgac     36960
     ccggactacc ccgccgaacg catcacctac atgctcgacg acgcccgacc cgccctgacc     37020
     ctgaccgagc cggtacccgt ggagaggtac acggggcact ccgtcacggc agtcacggat     37080
     gaggagcgcc gtagcccctg gtcggcacgc catgccgcgt acatgatcta cacctccggc     37140
     tcgaccggcc gccccaaggg cgtcgtcatc gagcaccacg ccctggccac ctacctccac     37200
     cgcgcccgca acacctacac cgccatgacc ggtgtgaccg tcctgcactc cccgctggcc     37260
     ttcgacctca ccatcaccgc cctgtggacg ccattgacaa gcggcggcac ggtccacctc     37320
     accagcctcg aagagtcgga cacgcaaccg agcctgatca aggccacacc cagccacctc     37380
     cccctgctca ccacactccc cgagacggcg tccccgtccc acaccctcat cctcggcggc     37440
     gaagccctcc acaccgacca cctcgtcacc tggcggaccc agcaccccgg cgttcagatc     37500
     atcaacgcct acggacccac cgaatccacc gtcaacatca ccgaccacca cgtaggcgaa     37560
     gacacccctg acggtcccgt ccccatcgga cggcccttcg ccaacaccca ggtctacgtc     37620
     ctcgactcgg ccctgcgccc cgtcgccccc ggcgtcaccg gagagctgta cctcgccggt     37680
     gaacagctcg cccgcggcta cctcggccgc cccgcgctga ccgccgaacg cttcaccgcc     37740
     aacccccaca gcagcacccc cggcgcccgc atgtaccgca ccggtgacct cgcccactgg     37800
     aaccaccacg gccacctcac ctacgacgga cgcgccgacc accagatcaa actccgcggc     37860
     caccgcatcg aacccggtga gatcgaagcc accctcaccg cacagaccgg catcacccaa     37920
     gccaccgtcc aactccgtga ggaccagccg ggcgaccagc gcctcgtcgc ctacctcgtc     37980
     gtcaacgact ccaccgaata cgacgagaaa accgtgcgcg acgcactcac gagcgcactg     38040
     cccgactaca tggtccccag cgcactcgtc accctcgacg ccctccccct cacccccaac     38100
     ggcaaactcg accgcaccgc cctccccgcc cccgcctact cggcatccac cgccggacga     38160
     gcacctcgca ccccccgcga agaagtcctc tgcaccctct tcgccgaagt cctcggcgtc     38220
     gacctcgtca ccatcgacga caacttcttc gacctcggcg gacactccct cctcgccacc     38280
     cgcctcgtct cccgcacccg caccgcactc ggcgtcgaac tgtccatccg gcagctcttc     38340
     gagacgccga ccgtggcggg tctcgccgag gccctcgacg cgtcgggcac cgtccgcacc     38400
     gcgctcaccg cgaggccgcg ccccgagcgc atcccgctct cctacgccca gcaacgcctc     38460
     tggttcctcc accagctcga aggaccatcg gcgacctaca acaccgtgct cacgctgcgg     38520
     ctcggcggcg cgctcgacgt ggacgccctg cgcgcggcga tcagtgacgt cgtcgcccgg     38580
     cacgagagcc tgcggacggt cttcaccgag gacgagcgag gcgcgtacca gatcgtgctg     38640
     cccgtggagg ctgcctcgac gcccttcacc gtcgtcgacg tggccgagga ggagatcggc     38700
     gaccggctcg acgaagccgt cggccactgc ttcgacctcg cccaggaact tcccgcgcgc     38760
     acctcgctgt tccgggtgtc ggagcgggag cacgtactgc tgctcctcat ccaccacatc     38820
     gccagtgacg cctggtcccg cgccccactg gcccaggacc tcaccgccgc ctacgcggcc     38880
     cgcgtccgca gcgaggcgcc catgtgggcc ccgctcaccg tccagtacgc cgactacgcg     38940
     ctctggcagc aggagatcct cggcgacgac accgatgccg acagcctcgc cggccgccag     39000
     ctcgcctact ggaaacagca gctcgccggc ctgcccgaac agctcgacct ccccaccgac     39060
     cggccccgac cggcggtcgc ggggtactcg ggggaccgtg ttccgttcac cgtgccgacg     39120
     gagctgcaca cgcggctgac ggagctggcg cgcgccacca acaccagtgc cttcatggtg     39180
     atccaggctg cggtcgccgt cctgctcacc cgtctgggcg ccggtgagga catcccgatc     39240
     ggcacccccg tcgccggacg cacggacgac gccgccgacg acctgatcgg gctcttcatc     39300
     aacacgctgg tcctccgcac cgacacgtcc ggtgatccga ccttccgccg actcctcgac     39360
     cgcgtgcggg acaccgacct ggccgcctac gcgcaccagg acctcccctt cgagcggctg     39420
     gtcgaggcgc tgaacccggc acgcacgctg tcccatcacc cgctcttcca ggtcctgctg     39480
     acgttcaaca acacggacca cgaaggcgcg ctgaaggaca tctccgagct tccggggctc     39540
     accgtcgcac ttcgggaggt ccagcggacc tcgtcgaagt tcgacctctc cttcgggttc     39600
     gcggagtcct tcgacacgtc tcgtcggcca caaggcatcg aagcggcact ggacttcagt     39660
     acggaacttc tcgaccgccg gtccgcccag gcgatcgcgg accggttcct gcgggtgctg     39720
     gaagccgtca ccacagcccc ggaccggccg atcggcgccg tcgagctgat ggacccggcc     39780
     gagcgggagc gggtcctggt ggagtggaac ggggccccga cccagcttcc cgggacaccg     39840
     ctgcacgaac tgatcagcga gcaggcccgg ttgacgccgg acgccgtggc ggtggtgtgc     39900
     gacggcacca ccctgaccta cgccgagctg gaccggcgcg ccaaccagct cgcccggcac     39960
     ctgctgggag aaggcctcgg tgcggaggac ttcgtcgcga tcgccctggc caagtcgctg     40020
     gacgcggtga tcagcatgct ggccgtgctc aagaccggcg cggcctacct gcccatcgac     40080
     ccggactacc ccgccgaacg catcacctac atgctcgacg acgcccagcc ggccctgacc     40140
     ctcaccgcgc ccataccgcc cgcttcgtac gacagccggc ccaccagcga gatcaccgat     40200
     gtggagcgcc gtagcccctg gtcggcacgc catgccgcgt acatgatcta cacctccggc     40260
     tcgaccggcc gccccaaggg cgtcgtcatc gagcaccacg ccctggccac ctacctccac     40320
     cgcgcccgca acacctacac cgccatgacc ggcgtgaccg tcctgcactc cccgctggcc     40380
     ttcgacctca ccatcaccgc cctgtggacg cctctcaccg ccggcggcac ggtccacctg     40440
     accagcctgg aggaggctga ggtccagccc agcctgatca aggccacacc cagccacctc     40500
     cccctgctca ccacactccc cgagacggcg tccccgtccc acaccctcat cctcggcggc     40560
     gaagccctcc acaccgacca cctcgccacc tggcgcaccc agcaccccgg cgcccagatc     40620
     atcaacgcct acgggcccac cgaatccacc gtcaacatca ccgaccacca cgtaagcgaa     40680
     gacacccctg acggtcccgt ccccatcgga cggcccttcg ccaacaccca ggtctacgtc     40740
     ctcgactcag ccctgcggcc cgtcgccccc ggcgtcaccg gagagctgta cctcgccggt     40800
     gaacaactcg cccgcggcta cctcggccgc cccgccctca ccgccgaacg cttcaccgcc     40860
     aacccccaca gcagcacccc cggcgcccgc atgtaccgca ccggcgacct cgcccactgg     40920
     aaccacgacg gccacctcac ctacgacgga cgcgccgacc accagatcaa actccgcggc     40980
     caccgcatcg aacccggcga gatcgaaacc accctcaccg cacagaccgg catcacccaa     41040
     accacggtcc aactccgcga agacaccccc ggcgaccaac gcctcgtcgc ctacctcgtc     41100
     gtcaacgact ccaccgaata cgacgagccc acccttcggg acgccctggc cagcgcactc     41160
     cccgactaca tgcgcccctc cgcctacgtc accctcgacg ccctccccct cacccccaac     41220
     ggcaaactcg accgcaccgc cctccccgcc cccgcctact cggcatccac caccggacga     41280
     accccccgca ccccccgcga agaaatcctc tgcacactct tcgccgaagt cctcggcgtc     41340
     gacctcgtca ccatcgacga caacttcttc gacctcggcg gacactcgct tctcgccacc     41400
     cgcctcgtca gccgcgcccg caccgcactc ggcgtcgaac tgtccgtgcg gcagttcttc     41460
     gagacgccga cgatcgccgg gctctcgggg gcgttcgacc gggccggccg tgcgcgggcc     41520
     gcgctcacgg cgaggccgcg ccccgagcgc atcccgctct cctacgccca gcaacgcctc     41580
     tggttcctcc accagctcga aggaccatcg gcgacctaca acatccccac caccctccgc     41640
     ctcaccggca ccctcgacac cgacgccctg caatccgcgc tcaacgacct cctcgcccgc     41700
     cacgaaagcc tgcgcaccac ctacaccgag gacggcgaag gcccccgtca ggtgatccac     41760
     gcctgggagc ccggaatgct gccgctcggc gtggtcgaca ccggggaggg cgagctggac     41820
     gcgatgctct ccgcgggggt tcatcacgcg ttcgacctca cggcgggcat cccggtgcgg     41880
     gccacgctgt tccggatctc ggagcaggag cacgtactgc tgctcctcat ccaccacatc     41940
     gccaccgacg cctggtcccg caccccgctg ggtcacgacc tcgccgccgc ctactcggcg     42000
     cgctgtgcgg gcgacgtgcc ggcgtgggag ccgctgcccg tgcagtacgc cgactacgcg     42060
     ctctggcagc gggaggttct cggcgacgaa ggcgacgccg acgcccccgc gggcaggcaa     42120
     ctcgcctact ggacacggca gctcgccgac ctgcccgagc agctcgacct ccccaccgac     42180
     cggccccggc cggccgtggc gagccaggac ggcgaccgcg tcgccttctc gctcgacgcg     42240
     gacctgtacg tgcggctgac cgagctggcc agggccaccc actcgagtac gttcatggtg     42300
     gtgcaggcgg cgctcgccgt actgctgacc cggctgggcg cgggcgagga catcccgatc     42360
     ggcaccccgg tcgccggacg caccgacgac gcgacggaga acctggtcgg cttcttcgtg     42420
     aacacgctcg tcctgcgcaa cgacaccagc ggcaacccca ccttccggga gctgctggag     42480
     gagacgcgcc gcaccgacct ggccgcctac gcgcaccagg acctcccctt cgagcggctg     42540
     gtggaggcgc tgaacccggc ccgtactctg gcgcaccacc cgctcttcca ggtgatgctg     42600
     atcctgagca cggcggagac ggacccggac gcctcgctgg cactgccggg actgcgggtc     42660
     ggcgcggagc gcagccggct cggggcggcc aaggtcgacc tggcgttcgc gctcgccgag     42720
     gtccgggacg gtgagggccg gagcaccggg ctgacgggcg cgctggactt ccggaccgac     42780
     ctgttcgacc gttccacggc ccggtccctg gtggagcggt tcgtgcggac gctggaggcg     42840
     gtcgtcgccg atcccggtgt gcggctgtcc cgggtgccgg tgctgaccgg gtccgaacgg     42900
     cgctcgctgc tcgaccgggg gaccggtccc ctgctggagg ggctggacgc gacgctgccg     42960
     gaactgttcg cggagcaggc gctccggacg cccggggcac cggcgctggt gcggggcggg     43020
     acgacggtgt cgtacgccga actcgacctg cgcaccaacc ggctggcccg gctgctgcgg     43080
     cagcaggggg tgcggccggg cacgccggtg gtcatgctga tggagcggtc gcccgcccat     43140
     gtcgtggcga cgctggccat cgccaaggcg ggcggcgcct acgtgcccct gcacgacacg     43200
     tatcccctcg accggatgcg gcacgtggtg gcggacaccg ccgcgacgct gatcctcacc     43260
     gaccgggccg aggcggcgcg ggccgggcag ctcggcgcgc gggtgatggt ggtcgacgag     43320
     ttcggcgccg ccccgtccgg ctcggaggcc gacgcggccc ccggcaccgg caccggcacc     43380
     ggcaccggct cgcgctccgg gtacgtcgac gatgctccgg aggtgggcct gcgcccgcag     43440
     gatctcgcgt acgtgatgta cacctccggg tccaccgggg tgccgaaggg cgtcgcggtc     43500
     acccaccgcg gggtcgtgga cctggtccgc gaccactgct ggcggccggg cgtccacgag     43560
     cgggtgctgc tgcacgcccc gcacgcgttc gacgtgtcct gctacgagat gtgggtgccc     43620
     ctggtctcgg gcggaacggt cgtcgtggca ccgcccggac acctggaccc ggccgcgatc     43680
     accgacctga tcaccgctca cgacatcacc gcgatccacc tcaccgcggg cttcttccgg     43740
     gtcgtcgcgg aggaggcacc ggagtgcttc gccggtgtgc gggaggtgct gaccggcggc     43800
     gacgtggtct cgccagccgc ggtggcccgg gtcctcgcgc accacccgcg gatcgtactg     43860
     cgtcacctgt acgggccgac cgagacgacg ctgtgcgtga cgcagcacga ggtcaccgcg     43920
     ccgtacgagg cccgcggcag cctgccggtc gggcgggcga cggggaacac ccgggcctac     43980
     gtgctcgacc ggtacctcca gccggtgccg gccggcgtgc cgggcgagct gttcatctcc     44040
     ggctccggtc tggcgcgcgg ctacctggac cgtcccgacc tgacctgtga gcggttcgtc     44100
     gccgatccgt acggcgggtc cggcgagcgg atgtaccgca cgggcgacct ggtccgctac     44160
     aacgcggcgg gcgaactgga gtacctggcc cgcgccgacg accaggtcaa gatccgcggc     44220
     ttccgggtgg aactgggcga gatcgaggcg gtcctggcca cgcgcccgga gctggcccag     44280
     gccgccgtcg tcgtccgcga ggaccggccc ggcgaccggc gcctggtcgg ctacgtggtg     44340
     gccgcggcgg gccgggacgg cgaggtcgac ccggacgcgc tgcgcgcctt ctcccgccag     44400
     gcgctgccgg actacatggt gccgtcggcg ttcgtggtcc tcggcaccct gccgctgacc     44460
     gccaacggca aactggaccg caaggcgctg cccgcgcccg actacggggc ggcgtccacc     44520
     gggcgggccg cccgcacccc tgccgaggag ctgctgtgca cgctcttcgc ccaggtgctc     44580
     ggcctgtccg cggtgggcgt cgacgacggg ttcttcgatc tgggcggcga cagcatcctg     44640
     tccatccagc tcgtcagccg ggcccgcgcc gccggactcg ccctcgccgt ccgcgacgtc     44700
     ttcgagcacc agtcgacggc ccggctggcc gccgcgctga cggaccggga cgacgcggcc     44760
     tccgtgccgg aggccgaagc ggtgccgccg tacggtcccg ccccgctgac ccccgtgatg     44820
     gcccgcatcg ccgaactggg cctgggcgga gacgacttca accagtcggt cgtggtgtcc     44880
     ctgccgcccg cggtggaccg ggaccggctc gtcccggccc tgcaacgtgt gctcgaccac     44940
     catgacgcgc tgcgcctgcg cgtcctgccc gacgggagca cggaggtacg cgccccgggc     45000
     agtgtgccgg ccgcggacgt cctgagcgtc gtcacgcggg cccccggcgc caccggcgag     45060
     gcgcgcgacg ccctgctcgt ggaggcggcg tgcgccgcac gggaccggct cgcaccggcc     45120
     gagggccgca tgctccaggc ggtcctggtc gacggcacgg acgacacgga cggcacgggc     45180
     gggacctccg gggcggacgg cgtgctgatc ctggtcgccc accacctggt ggtcgactcg     45240
     gtgacgtgga gcatcgtcgt accggacctc gccgcggcct accggggcga ggagcccgcc     45300
     ccggtgggca cctcgtggcg gcagtgggcc acctccctgg cacggctggc caccgacccc     45360
     cgcgtcgagg cggagaccgc ccactgggag cacacgctca ccggggcggg caccctgcgg     45420
     ctggaccgcg gccgcgatct ccagggcgac gccggacgca tcagcctcga cctggccccg     45480
     cacacgaccg aggccctgct cacgcgcctg cccgggggcg tcaacgcgag cgtgcacgac     45540
     gtcctgctga ccgccttcgc gttcgccgtc gccgggtggc ggcgcggacg cggcgaggac     45600
     ccggacgcgc ccgtcgtgct cgacctggag agccacggcc ggcacgagga ggcggtgccg     45660
     ggcgccgaac tcagccgcac ggcgggctgg ttcacggccc tccacccggt gcggctggct     45720
     ccggacgtca ccgactgggc gcggctgcac caggacggcg acgcgctccg ggacggcctc     45780
     aagcaggtga aggaacagtt gcggtccgta ccgggcgacg gcctcggcca cggcttgctg     45840
     cgccacctca accccaccgc tgggccccgc ctcgcacgcc ttcccgagcc cgacttcggc     45900
     ttcaactacc tgggccgccg ggtcaccccg gccaccggca ccccggaacc gtggaccgtc     45960
     acgggcggcg gcctcgccgc ctcgcggccc acggcgccga tggcccacgc ggtggagctg     46020
     agcgccgtcg tccacgaggg ggcggacggc ccccgactgc gcgcggagtg gacctacgca     46080
     cgccgcctgg tccccgatca cgacgcccgc cgcctggccg agcaatggtt ccgggcgctg     46140
     gaagccctgg tggagcaggc cgaccgggcc ggcaccggcg gcctgacccc gtccgacgtg     46200
     accctcggct cgctcagcca gtccgagatc gaggaattcg agtccgacct tgagtccgag     46260
     tgggagattg agcagtgagc cagcaaccga cccgtgcgcg cggcaagatc gaggacatcc     46320
     ttccgctctc cccgctgcaa gagggcttcg tgttcctcgg gctgctgcac accgaggggc     46380
     ccgacctcta catcggccag gtggccttcg acctggaggg ccccttcgac ggcgcccgga     46440
     tgcgcgaggc ggcccgggcg ctgctgcgcc ggcacgccaa cctgcgcgcc gggttccggc     46500
     agcgcaagaa cggggcctgg gcccaactgg tcctgcgcga cgtcgacctg ccgtggcagg     46560
     acgccgacct gagcacgctg tccgaggagg agcgccgggc ggaggccgac cggctcgcgg     46620
     ccgccgaccg tgcccgccgt ttcgacctgg gccggccccc gctgctgcgc ttcaccgcca     46680
     tccggctgtc cgccgaccgc gtccgcctgg tgatgaccaa ccaccacatc gtgctggacg     46740
     gctggtccat gccggtcctg ctgcgcgaac tcatggcgct ctacgccgcc gagggtgacc     46800
     cctccgcgct cccccgggtc cgtccctacc gcgactacct ggcctggctc gacgcccgcg     46860
     accgggacgc cgcccgcgac gcctggcggc ggtccctgtc cgggctcgac gaggccaccc     46920
     tcctcgcccc ggacgccggc ccggcgtcga ccgctccctc gcaggtgtcc ttcaccgtgg     46980
     actccgaggt cagcggcgcc ctgtcggcct gggctcgggg ccagggcgtg accatgaaca     47040
     cggtggtcca gggtgcctgg gccctcgcgc tggcccaggc caccggacgc gacgacgtcg     47100
     tcttcggcgc caccgtctcc ggccgcccgc ccgagctgcc cggcgtcgag tccatgatcg     47160
     gcctgttcat caacaccctg cccgtccgcg cccgcctcga ccaggccgaa cccctcggcg     47220
     acctcttccg ccgcctccag aacgaacagg cccgcctcct ggaccaccag tggcccggac     47280
     tcgccgacat ccagcactgg gccggacacg gcgaactctt cgacaccgcc atggtcttcc     47340
     agaactaccc ggtcgaggag ggcgacctca ccgcccccgc cgacccggac cggctccggg     47400
     tcgcctcggc cgacatcaag ggcggcacgc acttcgccgt caacgtcgtc gcgacgatgc     47460
     gcggcgccga actgtccttc cgcgtcgact accgacccga cctctacgac gaggcgtacg     47520
     cccgcgactt cggccgacgg atgctacggg tactggaaac cctgatctcc gacccggacc     47580
     gtcccgtggc ccacctggac accctcgacc cggccgtacg ggagcgggtc ctggtggagt     47640
     ggaacggggc cccgacccag cttcccggaa cgccgctgca cgaactgatc agcgagcagg     47700
     cccggttgac tccagacgcc gtggcagtgg tgtgcgacgg cacctccctg acctacgccg     47760
     agctggacgg gcgcgccaac cagctcgccc ggcacctgct cgaacgaggg ctcggagcag     47820
     aggacttcgt cgcgatcgcg ctgcacaagt ccctggacgc cgtcaccagc atgctggccg     47880
     tgctcaagac cggcgcggcc tacctgccca tcgacccgga ctaccccgcc gaacgcatca     47940
     cctacatgct cgacgacgcc cgaccggcgc tcaccctcag ggagcccgta ccggcggctg     48000
     catacggtca ccggcccacc gacgacgtca cggacgcgga acgacggacg ccctggtcgg     48060
     cactccatgc cgcgtacatg atctacacct ccggctcgac cggccgcccc aagggcgtcg     48120
     tcatcgaaca ccacgctcta gccacctacc tccaccgcgc ccgcaacacc tacaccgcca     48180
     tgaccggcgt gaccgtcctg cactcacccc tggccttcga cctcaccatc accgccctgt     48240
     ggacgcctct caccgccggc ggcacagtcc acctgaccag cctggaggag gctgaggtcc     48300
     agcccagcct gatcaaggcc acacccagcc acctccccct gctcaccaac ctggcagcca     48360
     cggcatcccc gtcccacacc ctcatcctcg gcggcgaagc cctccacacc gaccagctga     48420
     ccgactggcg cacccagcac cccggcgccc agatcatcaa cgcctacgga cccaccgaat     48480
     ccaccgtcaa catcaccgac caccgcctcg acggcacgga agaaggcccc gtccccatcg     48540
     gacggccctt cgccaacacc caggtctacg tcctcgactc agccctgcgg cccgtcgccc     48600
     ccggcaccac cggagagctg tacctcgccg gagaacaact cgcccgcggc tacctcggcc     48660
     gccccgccct caccgccgaa cgcttcaccg ccaaccccca cagcagcgtt cccggcgccc     48720
     gcatgtaccg caccggcgac ctcgcccact ggaaccacca cggccacctc acctacgacg     48780
     gacgcgccga ccaccagatc aaactccgcg gccaccgcat cgaacccggc gagatcgaaa     48840
     ccaccctcac cgcacagacc ggcatcaccc aagccaccgt ccaactccgt gaggaccagc     48900
     cgggcgacca gcgcctcgtc gcctacctgg tcacctccac cggatacgac gagaacaccg     48960
     tgcgcgacgc cctggtcagc gcactgcccg actacatggt ccccagcgca ctcgtcaccc     49020
     tcgacgccct ccccctcacc cccaacggca aactcgaccg caccgccctc cccgcccccg     49080
     cctactcggc atccaccacc ggacgaaccc cccgcacccc ccgcgaggaa atcctctgca     49140
     ccctgtactc ggagatcctc tcggtgaaca ccgtgggcat cgacgacagc ttcttcgacc     49200
     tcggcgggca ctccctcctc gccacccgcc tggtgagccg catccgcacc accctcgggc     49260
     gggagctgcc gatccggcag cttttcgaga cgccgaccgt cgctggcctc tcccgtgccc     49320
     tggacacgtc cggcaccctg cgcaccgcgc tcaccgcgag gccgcgcccc gagcgcatcc     49380
     cgctctccta cgcccagcaa cgcctctggt tcctccacca actcgaagga cccaccgcca     49440
     cctacaacat ccccaccacc ctccgcctca ccggcaccct cgacaccgac gccctgcaat     49500
     ccgcgttcaa cgacctcctc gcccgccacg aaagcctgcg caccacctac accgaggacg     49560
     atcagggcgc ccagcagatc gtgttgcccg tggaggccgt cgcgacgccg ttcgccgtcg     49620
     tcgacgtggc cgcggaggac gtggcggaac gggtggccga ggcggcggcg cacgccttcg     49680
     atctgggcgc ggagatcccg gtacgggcgc ggctgttccg ggtctcggag cgggagcacg     49740
     tcctgctgct gctcgtgcac cacatcgcca gtgacgcctg gtcccgcggc ccactggccc     49800
     aggacctcac cgccgcctac accgcccgct gcgccgacga cgcacccgcc tggcagcccc     49860
     tccccgtcca gtacgccgac tacgccctgt ggcagcagga gatcctcggc gacgacaccg     49920
     accccgacac cctcgccggc cgccagctcg cctactggaa acagcagctc gccggcctgc     49980
     ccgaacagct cgacctcccc accgaccggc cccggcccgc caccgccgac cacaccggcg     50040
     accgcgtcac cttcaccgtc cccgccgacc tgcacacccg tctgaccgaa ctcgcccggg     50100
     agaccaacac cacggcgttc atggtgatcc aggcggcgtt ggcggcgttg ctgacgcggc     50160
     acggcgcggg cgaggacatc ccgatcggca cccccgtcgc cggacgcacc gacgacgcca     50220
     ccgaccacct catcggcttc ttcgtcaaca ccctcgtcct gcgcaccgac accagcggca     50280
     accccacctt ccgcgacctc ctcacccgag tccgcgacac cgacctcacc gcctacaccc     50340
     accaggacct ccccttcgaa cgcctcgtag aagccctcaa ccccacccgc tccctcaccc     50400
     accaccccct cttccagacg atgctcaccc tgcacaacac gcagggcacg aagacggacc     50460
     ggttcgccgg gctggctgcg gaggtggtgg cgtcggagtc ggtgtcggcg cgcttcgacc     50520
     tgtcgttcgc gctggccgag cacttcggtg ccgaccattc ctgcgcgggc atgagcggcg     50580
     gcgtcacgta cagcacggcg ctcttcgacc gtgccacggt gcgggacctc gccgaccggc     50640
     tggtgcggtt gctcgcggcg gcggtggcac acccggggcg gtccgtgggg cagttggaaa     50700
     tcatggacgc ggccgaacgg cggctggtcc ttcaggagtg gaacgacacc gcggccgagc     50760
     cgccggccgc gtcggtgacc gggctcttcg agcggcaggc gcggcggtcg ccgggggcga     50820
     cggccctgga gttcggcgag gtgcggctgt cctacgcgga gctgaacgcg cgcgccaacc     50880
     ggctggcccg gcatctcgtc gcgcggggcg cggcgccggg ccggttcgtg gccgtggcgc     50940
     tgccccgctc ggcggagctg gtcgtgacgc tgctggcggt cctcaagtcc ggggccgcct     51000
     acctgccgat cgacccgcac tacccggccg accgggtgga gtacatgctg gccgacgcgg     51060
     ggcccgcgct cacggtgacc gaaccggtgg cggaggccgg gctgtcgggg tacggggacg     51120
     cggacctcgg ggcggacgag ctgcggggcc cggtccacgg ggcgcatccg gcgtacacga     51180
     tctacacctc gggttccacg gggcggccca agggcgtggt ggtgccgcgc ggggcgctgg     51240
     acaacttcct ggccgacatg ggccggcggt tcacgccggg gtccggtgac cggctgctcg     51300
     ccgtgaccac ggtgggcttc gacatcgcgg gcctggagat cttcctcccg ctgctgcacg     51360
     gcgcggtgct ggtgctcgcc gacgaggaga ccgcgcgcga cccgcacgcg ctgctgcacc     51420
     gggtgtcggc gtcggggatc accatggtcc aggcgacgcc gagcctgtgg cagggggtcg     51480
     cggccgtggc cggggacgag ctggccgggg tgcgggtgct ggtgggcggg gaggcgttgc     51540
     cgtccgagct ggcgcgggcg ctgacggacc gcgcccgctc cgtgacgaac ctgtacgggc     51600
     cgacggaggc gacgatctgg gcgacggcgg ccgatgtcgc cgagtccggg ccggtcatcg     51660
     gccggccgct cgccaacacc tcggcctacg tgctggactc ggcgctgcgg ccggtcccgg     51720
     tcggtgtgcc gggcgagttg tatctggccg gggagcagtt ggcgcagggt tatcacctgc     51780
     gtcccgcgct gacgtcggag cggttcaccg ccgacccgta cggcccggcc ggtacccgga     51840
     tgtaccgcac gggcgacctg gtgtgccggc gccgggacgg tgcgctgcgc tatctgagcc     51900
     gggtggacca gcaggtcaag ctgcggggtt tccgtatcga gctcggggag atcgaggcgg     51960
     agctgtcccg gcatccggcg gtggccgagt ccgcggtgac ggtgcgcgag gaccggccgg     52020
     gcgaccggcg gctggtcggg tacgtcgtac cgaagggtcc ggagggaccg gcgggtccga     52080
     caggtccggt gccgagcgcg cgggagttgc gggagcggct gcgcggacgg ctgccggagt     52140
     tcatggtgcc gacggcgttc gtggtgctcg acgcgctgcc gctgacgccg aacaggaagc     52200
     tggaccgcaa ggcgctgccc gctccggagt acgacggcga gccggtgggc cgggggccgc     52260
     gggatccgcg cgaggagatc ctgtgcgcgc tgttcgccga ggtgctgggc gtcgcccggg     52320
     tcggcatcga cgacggcttc ttcgacctgg gcgggcactc gctgctcgcc acccggctgg     52380
     tcagccgcat caggacggcg ctgggcgtcg aactgtccgt gcgccagttc ttcgagacgc     52440
     cgacgatcgc cgggctctcc ggcgccctgg accgggcggc gggcgcgcgg gcgccgctgg     52500
     cggcccggcc gcgtccggag cgggtcccgc tgtcgccggc gcagcagcgc ctgtggttcc     52560
     tgcaccagtt cgagggcccg tcggcgacgt acaacatgcc gacggcgctc cggctgtccg     52620
     gtccggtgga ccgggcggcg ctggagcggg cgatcggtga cgtgctggtc cggcacgaga     52680
     gcctgcggac cgtgttcgcg gcggacgacg gggggtcgtg gcaggtcgtg ctgcccgccg     52740
     accgggccgt cggccgcctg gacgtggtcg acgtgaccgc cggggaggtg gcggagcggg     52800
     tcggcgaggc ggcccggcac gccttcgacc tgacggccga catcccgttc ctggcccggc     52860
     tgttccgcgt ctcggacacc gagcacgtcc tgctgctgct catccaccac atcgcgggcg     52920
     acggctggtc gatggccccg ctggcccgtg atctcacggc cgcgtacgcg gcgcgctgcg     52980
     cgggcgcggc accggactgg gagccgctgc cggtgcagta cgccgactac gcgctgtggc     53040
     agcgggaggt cctcggcgac gagtccgacc ccgacagcgt ggcggcgcgg cagctggcct     53100
     actggaagga cgccctggcg gggctgccgg agcagttgga gctgcccacc gaccggcccc     53160
     gcccggcgac cgccggatac accggcgacc gcatcgcgtt cacggtgccg acggcgctgc     53220
     acgcgcggct gacggagctg gcgcggtcca cgcactccag cctgttcatg gtggtccagg     53280
     cggcgttcgc cacactgctg acgcggctgg gggcgggcga ggacattccc gtcggcacgg     53340
     cggtcgcggg gcgcaacgac gccgccaccg aggatctcgt cggcttcttc gtgaacacgc     53400
     tggtgctgcg caccgacacc ggcggcaacc cgaccttccg cgagctgctg ggccgggtgc     53460
     gcgagcgcga cctggccgcg tacgcgcacc aggacgtgcc gttcgagcgg ctggtggagg     53520
     cgctgaaccc ggcgcgcagt ctggcccacc acccgctgta ccaggtgatg atcaccttca     53580
     acaacacggc cggtgcgggc gaccgcaccg cgcccgcctc cccggacacc ccggacgtgt     53640
     ccgggcaggc cggagcgctc ctgaacgcga cccggatgac ggccggtacc ggggtggcca     53700
     agttcgacct ggcgctgacc ttcggcgagc ggcacgatcc gtcgggcggt cccgcgggca     53760
     tgcgcggttc gctggagtac cgcacggagc tgttcgaccg ggagaccgcg gagtcggtga     53820
     tctcgcggct gctcggggtg ctgggctcgg tcaccgccga cccggaccgg ccgatcggcg     53880
     ggatcggcct gctggacccg gccgagcggc gccaggtgct gcgggagtgg aacgacaccg     53940
     cgcgcccgca gcgcgagggg accctgcccc ggctgttcga ggagcaggtc gccaggactc     54000
     cgcgccgccc ggcgttctcg gccgccggga cgacgctgac gtacgccgag ctgaactcgc     54060
     gtgccaaccg gctcgcccat ctcctcgcgg agtccggggc gggcccggag caggtggtgg     54120
     cgatctcgtt gccgccgtcg gtggagatgg gcgtggcggt gctcgcggtg ctgaagacgg     54180
     gggccgcgta cctgccggtc gacccgggca gtccgcgcga gcggatcgcc accatggccg     54240
     aggacgcggc gccggtgtgc gcgctgacga cgtccgcggt cccggccggg gtgttcccgg     54300
     cggagctgcc ccggctgctg ctcgacgacc cggacgtcac cgcccggctg gcggcgcagc     54360
     ccgcgcacga cctgacggac gaggaccgca cgcagccgct gtcgccgtgg aacgcggcgt     54420
     acatcatcta cacgtcgggc tccacgggcc gccccaaggg ggtgctcgtg gagcaccagc     54480
     cggtgctgaa ctacctggcg gtgtcggcgg agctgtaccc gggcgtggcg ggcaacgcac     54540
     tgctgcactc gccgctctcc ttcgacctga cggtgacggg tctgttcgcg ccgctgctga     54600
     acggcggctg cgtgcacctc gcggacctgg aggagctgca cgcgcgggcg ctggacggcg     54660
     aggtgcccga cctgccgcag acgacgttcc tgaaggcgac gccgagccat ctgccgctga     54720
     tcaccgggct gcccggggtg tgcgtgccgg acggggagct ggtcctgggc ggcgagtcgc     54780
     tgaccggccg cgcggtgcgg acgctgctcg cggcgcatcc gggggcgcgg gtcctcaacg     54840
     agtacggtcc gaccgagacg atcgtgggct gcacgacctg gcgggtcgag gcgccggacg     54900
     acctcgcgga cggtgtgctg accatcggcc gcccgttccc caacacgcgc atgctggtcc     54960
     tcgacccgta cttgcagccc gtaccggccg gggtgccggg cgagttgtac gtgtccgggg     55020
     tgcagctggc gcgcggctat ctgaaccggc ccgggcagag cgcgtcccgg ttcgtcgcca     55080
     accccttcga ggggccgggc gagcggatgt accgcaccgg cgacatcgtg cgctggaacc     55140
     ggcggggtga cctggagttc atcagccggg tcgacgacca ggtgaagatc cgcggcttcc     55200
     gggtggagct gggcgaggtc gagtcggccc tgtcgcggca gccgggggtg ccggaggcgg     55260
     tggccgtggt gcgcgaggac cggccgggcg accggcggct ggtggcgtac ctggtgaccg     55320
     gagccggacc ggtgccggtg ccctcggacg aggagctgcg ggagcggctg cgcgagacgc     55380
     tgcccgacta catggtgccg tcggcgttcg tgcgcctgcc ggagctgccg ctgaccggca     55440
     acggcaaact ggaccggggg cggctgcccg caccggacta cgcggccgcc ggcacgggcc     55500
     gggccccggt cacggcgcgc gaggagctgc tgtgcgcgct gttcgccgag gcgctgggcc     55560
     tggagtcggt cggtgtcgac gacggcttct tcgacctggg cggcgacagc atcctgtcca     55620
     tccagctggt cagccgggcc cgcgcgaagg gcctcacgct ctccgtgcgg gacgtcttcg     55680
     agcaccagag cgtcgcccgc gtcgccgagg cactcgaact cgccgaggcg caggccgccg     55740
     acggcgcggc gggggcgtcg gcgggtgccg taccgggagc ggcggaagag gaggcagcgg     55800
     cgagcgggcc ggtgcccgcg acgccgatca tggggtggtt cgccgcgctg ggcgggccgg     55860
     tcgcgccgtt caaccagtcg gtggtggtgt cggtgcccgc ggacctggac gcggagcggc     55920
     tggtggccgc cctcggggcg ctcctggacc ggcacgactc gctgcggctg cgggtcgccg     55980
     cggactggtc catgtccgtg cccgagcccg agcccggcgg cacggacgcc gccggtctcc     56040
     tcacgcgccg cgcggccggg gacgtcgacg acgccgggct gcacgctctg ctggccgagg     56100
     cgggcgccgc cgagcgcgac cggctgtccc cggccgacgg gcggatgctg cgggcctgcc     56160
     acgtcgaccg tgggccggac cggccggggc tgttggtcct ggtcgcccac cacctggccg     56220
     tggacgcggt cagctggcgg ctgctcgtgc cggacctggc cgccgcctac gagggccgcc     56280
     cgctcagccc ggcgggcacc ggctggcgcc ggtgggcgtc ggcgctgcgg gacctggccg     56340
     gctcccccgt caccgaggcc gagacggacc actggctgga cgcggcccgc ccggccgccg     56400
     agccggcgga cccggtactg gatccggcgc gcgacaccca cgcccgctcg gggcaggtcg     56460
     tcctcgacct cgacccggac accaccgacg ccctgctcac ctgggtgccc ggggtgttcc     56520
     gggcggagat caacgacctg ctgctcaccg cgttcgggct ggccgtcgcc gactggcggc     56580
     gcgaccgggg cgcccggggc acggcgcccg tcacggtgga cctggagagc cacggccgcc     56640
     acgagcacct ggtgccgggc gccgacctca cccgcaccac cggctggttc acctcgatgc     56700
     acccggtgcc gctgcacccc gaggtcgacg acccggactg ggccgaggtg tgggacggcg     56760
     gggcagcggc cgggcgggcc ctgaagcggg tcaaggagca actgcgcgcc gtcccgcgcg     56820
     acggtgtggg ccacggcctg ctccgtcacc tcaacccgcg cacccgggac cgtttcgccg     56880
     ccctgccgac accggcgtac ggcttcaact acctgggccg ccacaccggc ggccggggcg     56940
     gcggcgcacc gggcggcggc gccgggcccg agccgtggag cgtgctcggg cggggcgtgg     57000
     cggggcagca ccccgacacc ccgctggcgc acccggtgga actggtcgcg ggcgcccacg     57060
     acaccgacgc ggggcccacg ctgcacagcg tgtggacgta cgcggacgcc gtgctgtccg     57120
     agaccgaggt gcggcgcctg ggcgagggct ggttccgggc cctgaaggcg ctggtcgagc     57180
     acgccggccg gcccgaggcg agcggtctga ccccctcgga cgtctccctc acctcgctca     57240
     gcgaggacga catctcccga ctcgagagcg aatggggttc cctctgatgg ccaagtccgg     57300
     cttggaagac atcctgccgc tgtccccgct ccaggagggg atgctgttcc acaacctctt     57360
     cgacgaggag gaactggacg cctacaacgt ccaggtcttc atcgacctgg agggcggcac     57420
     ggacccggag cggctgcgcc gggccgggca ggcgctgctg gagcggcacg ccaacctgcg     57480
     ggccgccttc cggcacgagg ggctcaagcg cccggtgcag ctcatccccc gccgggtcgt     57540
     cctgccctgg ggcgaggagg acctgtcggg cgtcgccgaa ccggagcggg aggcggcggc     57600
     ggagcgggtc gccgagcggg accgctggac gcgcttcgac ctgtcccggc cgccgctgat     57660
     ccgcttcacc ctggtccggc tcggcccggc ccgtcaccgg ctgctgctga cgctccacca     57720
     catcctggcg gacggctggt ccatgccgat cctgctgcgc gagctgatga ccctgtacac     57780
     cgtccacggc gacggtacgg ccctgccccg ggtgcgcccc taccgcgact acctgggctg     57840
     gctcggcggc cgggaccggg acgccgcccg gcaggcctgg acggaggcgt tcgccgggct     57900
     cgacgcgccg agcatcgtcg cccccggccg gggcgcgctc accgcggcgc ccgagcggat     57960
     cgacttctcc gaggacgagg cggcgagcgc cgcgctgacc cggttcgccc ggtccaacgg     58020
     gctgacggtg aacacggtga tccagggctg ctggggactg gtcctgtccc atctgacggg     58080
     ccgggacgac gtggtgttcg gcgtgaccgt cagcggccgc ccgccggagc tgcccggtat     58140
     cgacaccatg gtcggcctgt tcatgaacac cctgccgctg cgggtgcggc tgcggcccgc     58200
     cgagacgctg accgggttcc tgcgccggct gcagggcgag caggcgcggc tcatcgacca     58260
     ccagtgggtg ggcctcgcgg agatccagcg ctgggcgggt tccggcgaac tcttcgacac     58320
     ggccatggtg ttcgagaact atccgctcaa ctccagccgc ggccgccccc cgggggccgc     58380
     gccggacgcg gacctcccga ccgtcctcgg ggtccgttcg aaggaccaga tgcactaccc     58440
     gctgggtctg ctggccctgc cccgcgagac cctgcggttc tcgctgggct atctgccgca     58500
     ggtcttcgac ccggcgcggg tcgaggcggt gatcgccgcg ttccgccggg cgctgcgcac     58560
     cgtcctggac gccccggaca cccgggtcgg cgcggtcgcg ctgctcgacc cggaggtgcg     58620
     gggcaccgtc ctggagaagt ggagcggctc ggacgacgtg cggcccgcag agcggttcac     58680
     cgacctgttc gaggagcagg tggcgcgcac ccccggcaag acggcgctga tcgcccccga     58740
     cgggcggctg acctacgccg aactcgacgc cgccgccaac cggctggccc gtcgcctggt     58800
     cgagctgggc gtcggcccgg aacggcacgt ggcggtcgcg gtggggcgcc gcacggaact     58860
     ggtggtcggc atgctggcgg tgctcaaggc gggcggcgcc tatgtgccgg tcgacccgga     58920
     gtacccgccg gaccgcatcc gccacatgat ccaggacgcg gaccccgcgc tcgtcctcac     58980
     cacctccgac gtggacgacc ggatcggcga ggagtgctgc gggccgctga cgttcgtcat     59040
     ggacgacccc aacaccggaa cgtcgctggg caggcactcc gggacggctc tcaccgacgc     59100
     cgaccgcgcg gcgccgctgc tgccgggcca tccggcgtac gtcatctaca cctcgggcac     59160
     gacgggccgc cccaagggcg tcgtcgtcga gcaccgggcc ctgtcggcgt tcgtgcggca     59220
     ctgccggtcc tcccaggcgc cggacatctc ggggctgtcc gtgatgcagg cgtccgcgtc     59280
     cttcgaccag agcgtcggct cgctgcacgc cccgctgatc agcggcggct gcgtccggct     59340
     gacggatctg cgcgccctcg ccgagacggc cgggtccgaa cccggcttcc accgtgccac     59400
     cttcatgaag ggcaccccgt cgcacctggc gctgctggcc accatgccgc cggaggtcgc     59460
     gccctcgggc accctgaccc tgggcggcga ggagctgcgc ggggagatcc tggcaccctg     59520
     gcgcgaggcc gcgggggacg tgacggtggt gaacgtctac gggcccaccg aggccaccgg     59580
     tcactgcctg gagcactgga tcgccccgga ccgcacggtg gagccgggcc cggtgccgat     59640
     cggcaccccg cacgaggggg tgcgggtgta cgtcctcgac tccgcgctgc gcccggtcgc     59700
     accgggtctg gacggcgagg tgtacctggc gggcgtgcag ctggcgcgcg gctacctggg     59760
     ccgcggcggg ctgaccgccg agcggttcac ggccgacccg ttcggcgcgc cgggcagccg     59820
     catgtaccgc acgggcgacg tcgcgcactg gaacgaagcg ggggagctgg tcttcgccgg     59880
     gcgcgcggac cggcaggtca agctgcgcgg gtaccgcatc gagctgggcg agatcgaggc     59940
     cgccgtcgcg ggcgggccgg gtgtgcgcca ggccgcggtc gtcctgcgcg aggaccggcc     60000
     gggcgaccag cggctggtgg cctacgtcgt cccggacccc ggccactggg acgaggccgc     60060
     cgcccgtgcc cggctggccc tgtccctgcc ggacttcatg atgccctcgg ccttcgtcgc     60120
     cctggacgcc ctgccgctca gcccgaacgg caagctggac cgggcggcgc tgcccgcccc     60180
     gacgtacacc ggccggaccg cgggccgggc accgcgcacc cccgccgagg agatcctctg     60240
     cgacctgtac gcggaggtcc tgtcgctgcc gggcgtcacc gtcgacgacg acttcttcga     60300
     cctcggcggt cactccctgc tcgccacccg gctcgtcagc cgggtccgca ccacgctggg     60360
     ggccgagctg tccatccggc agttcttcga ggcgccgacc ccggccgcgc tcgccgtggt     60420
     gctcgccggg gcgggccggg cgcgggccgc gctcaccgca cggccccgtc ccgagcgcct     60480
     cccgctctcc tacgcccagc agcgcctgtg gttcctccac ctgctcgaag ggccgagccc     60540
     cacctacaac atcccgacgg tgctccggct gagcggaccg ctgcgcccgg acgcgctgcg     60600
     cgcggcgctg ctggacgtgg tcgggcggca cgagagcctg cggacgacgt tcaccgagga     60660
     cgagcggggg gcccggcagg tggtgcaccc cgccgacggg gtccggccgg tcttcgagac     60720
     ggccgagtcc acggaggccg actacgaggc cgacctcgca cgggcggccc ggcacgcctt     60780
     cgatctgggc gcggagatcc cggtacgggc gcggctgctg cggctgtcgg agcgggagca     60840
     cgtcctgctg ctgctcgtgc accacatcgc cagcgacgcc tggtcccgcg gcccactggc     60900
     ccaggacctc accgccgcct acaccgcccg ctgcgccggc gacgcacccg cctggcagcc     60960
     cctccccgtc cagtacgccg actacgccct gtggcagcag gagatcctcg gcgacgacac     61020
     cgaccccgac accctcgccg gccgccagct cgcctactgg aaacagcagc tcgccggcct     61080
     gcccgaacgg ctcgacctcc ccaccgaccg gccccggccc gccaccgccg accacaccgg     61140
     cgaccgcgtc gagttcgccc tccccgccga cctgcacacc cgtctgaccg aactcgcccg     61200
     ggccaccgac acgaccctct acatggtgct ccaggccgcc ctcgcgacgc tgctcacccg     61260
     gcacggcgcc ggtgaggaca tcccgatcgg cacccccgtc gccggacgca ccgacgacgc     61320
     caccgaccac ctcgtcggct tcttcgtcaa caccctcgtc ctgcgcaccg acaccagcgg     61380
     caaccccacc ttccgcgacc tcctcacccg agtccgcgac accgacctca ccgcctacac     61440
     ccaccaggac ctccccttcg aacgcctcgt agaagccctc aaccccaccc gctccctcac     61500
     ccaccacccc ctcttccagg tggtgctgtc gctgcgcagc accgcaccgc ggcgggcgga     61560
     cggggagggc gcgccggcgc tgccgggcgg gctgagggtg agcggcacgg gcggtgcggc     61620
     ggcgacggcg gccaaggtcg acctcgggtt ctcggtgacg gagcgccggg cggccgacca     61680
     cacccccgac ggggtggcgg gcgtcctcga cttccgcacc gacctcttcg accgcggcac     61740
     cgcgcagggt ctggtggacc ggctggtgcg ggtgctcgcc gacgcggccg cccaccccga     61800
     ccggccgctg agccgcatcg acgtgctcgg accgcgggag cggcaccggg tcgtcgagga     61860
     gtggaacgcg acggcgaagg ggctcgcccc ggccaccctg cccgagctgt tcgagcggca     61920
     cgtgcgggag cgccccggcg ccgaggcggt ggtcgccggc gacacgtcgc tgagctacgc     61980
     ggagctgaac gcgcgcgcca accggctggc ccggctgctg gtggcgcggg gcgcgggccc     62040
     cgagcggctg gtggcgctgg cgctgccccg ctcggccgaa ctgcccgtcg ccgtcctcgc     62100
     ggtggccaag gcgggcgccg cctacctgcc gctggacccg gcccacccgg cggagcggat     62160
     cgcgggcacc ctcgacgacg cggcaccggt cgcgctgctg accacggccg cggtggccgc     62220
     cggcctcccg gacacggacg tgcccaggct gctccttgac gaggagcccg cggccggcgg     62280
     tggcgaggac gccgccgacc tcaccgacgc cgaccggctc gcgccgctgc tgccggggca     62340
     tcccgcgtac gtcatctaca cctccggcac caccggccgc cccaagggcg tcaccgtgac     62400
     gcactcgggc ctgcccgccc tgctggacat cttcacctcg cagctggacg tcgtacccgg     62460
     cagccgcgtc ctgcaccacc tctcccccgc cttcgacggc gggttctggg agctggcgat     62520
     ggggctgctg accggtgcgg ccctcgtcgt cgtggagccc ggcaccgtgc cggggcccgc     62580
     cctggccgcg ctggcggtcc gccaccgggt cacccacgcg gcgatcaccc ccgcggtgct     62640
     ccagctgatc cccgagggcg cgctgcccgc cggcacgacc ctggtcgtcg ccgccgagac     62700
     ctgcccgccc gaactggtcg cccgctggtc cgcgggacgc ctgatgcgca attcctacgg     62760
     gccgacggag accacggtct gcgccaccat gagcgccccg ctggcgggcg cggccgtccc     62820
     gccgatcggt aggccgatcg ccgacaccgc cgggtacgtc ctggacgacg cgctccagcc     62880
     ggtgccgccg ggcgtgcccg gggagctgta cgtgcgcggg cccggactcg cccgcggcta     62940
     cctgggccgc ccgtcgctga ccgcgggccg cttcgtggcg tgcccgttcg ggccggcggg     63000
     cggcgtgatg taccgcaccg gcgacctggt acgccaccgc gcggacggcg acctggagta     63060
     cctgggccgc accgacaccc aggtcaagct gcgcggcatg cgcgtagagc cggccgagat     63120
     cgaggcggtg acggcgggcc tgcccggcgt ggcgcaggcg gccgtgctgg tccgcgagga     63180
     cacgcccggc gaccgccgcc tggtcggcta cgtcgtgccg gacgccgggg cgagtgtgga     63240
     ccccggcgcg ctgcggcagg cgctgcgcgg ctcgctgccc gagtacatgg tgcccgccgc     63300
     cctcgtggtc ctcgacgcgc tgccgctcac caccaacggc aagctggacc accgtgcgct     63360
     gcccgccccg gagtaccgca ccgtcgaggg ccgctcgccg cgcaccccgc gcgaggaggc     63420
     cctgtgccgg ctcttcgccg aggtcctcgg tctggagctg gtcggtctcg acgacggctt     63480
     cttcgacctg ggcggccact cgctgctggc gatccggctc gtggagcggg tccgtgccga     63540
     gctgggcgag gagctgggcg tgcgcgacct gttcgccgct cccacggtcg ccgacctggc     63600
     ggtgcggctc gcggcgcgcg gcggccggga gccgatggag cggctgctcc cgctgcgtgc     63660
     cgccggtacc gcccggccgg tgttctgcgt ccaccccggt tccggcatga gctggtgcta     63720
     ctccggcctg gtgcgccacc tgccgcccgg tatcccggtg tacggcctcc aggccgccgg     63780
     actcgacggc gacgggccgc tgcccgcgac gcttcaggag atggccgccg agtacgcgga     63840
     tctggtccgg cagacgcagc ccgagggccc gtaccggctg ctgggctggt cgctcggcgg     63900
     caacgtggcc ttcgccatgg cccgcgaact ccgcgcccgc gggcaggagg tggagctgct     63960
     ggccttcctg gacgcctatc cgcgccgggc gggcgcgggc ccggaggccc cgctggccga     64020
     ggtgttcgcg cacaacctgc gcgacgccgg gttcgacgtc gccgaggagg agctcaccgg     64080
     cggccgcttc cccacggccc gctaccgcgc gttcctgaac gccgccgggg acccgatggg     64140
     ccgcctggac gaggccgaac tggccgcggt cctggaggtg ttcatgaaca acgcggccct     64200
     gatgcgcggc cacacccccg gcacctacga cggcgacgtg ctggtgctgg cggccgagcg     64260
     ggcggacggc gacaagctgg cccgccgcgg cgccgagtcg tggcgcccgc acgtgcgggg     64320
     ccggatcgaa cgggtcggtg tcgacgccga ccacctcggc ctcgtgcagt ccgacgccgc     64380
     cctcgccgtc atcggccgcg cgctggccgg ccgcctggac ccggcgacgg gccacgcggc     64440
     ttccgcagca gttcccgaga ccgaaggagt caccgccatg aacccctcgc ccgagcccgc     64500
     cccgtcgccc gagtcgctcg attcgaccga ggtcgcctga gccatgcccg tcctcaccgt     64560
     caacggcatc aggatcaact actacgacga cgcgcccccg gcgggtgcgc agaacgcgcc     64620
     cgccgtgctg ctcgtcatgg gctcgggcgg cagcggccgg gcctggcacc tgcaccaggt     64680
     gcccgcgctg gtcgccgccg ggttccgggt gatcagcttc gacaaccggg gcatcgcgcc     64740
     gagcgaggag tgccccgggg gcttcggcat cgacgacctg gtcgccgaca cggcggccct     64800
     cgtcgaggaa ctgcggctgg ggccctgccg ggtggccggc atctcgatgg gcgcgcacat     64860
     cgcccaggag ctggccctgt cccggcccga cctcgtggac cggctggtcc tgatggcgac     64920
     ccgggcccgc ccggacgcgc tgcgcgaggc gctgtgccgc gcggagatgg agctgtacga     64980
     ccaggggatc aggctgcccg ccgcctacga ggcggtcgtg caggccatgc agaacctgtc     65040
     gccgcgcacc ctcgacaacg acgtgcaggc ccgcgactgg ctggacgtgc tggaactgac     65100
     ccggcgctcc ggtgcgggct accgggccca gctcggggtg cgggtggacg gcgaccggcg     65160
     ggaggcctac cgcggcatcc gggccgccac ccgcgtcgtc gccttccagg acgacctgat     65220
     cgccccgccc cacctgggcc gggaggtggc cgacgcgatc cccggcgccg agtacgagct     65280
     ggtgcccgac tgcgggcact acggctacct ggagtcgccg gacgcggtga acaagagcct     65340
     cgtcgaattc ctgcgccggt gaaggagaac ccgttgaaga ctgagtccga tgtccagacc     65400
     ggtgcgccga cggccgccga cggcgcgctg atcgcgctgg cccgtgaggt gtgcccaggc     65460
     ttcgcccccg gggaggtcgt ctaccgcagc cgcacctcgc tggtggtggg cggcgagctg     65520
     gacggcgtcg aggcgctggc caaggtgcgc acgcccgact ggcggcgcca gtgcctgcgc     65580
     gagatcgaca cctacgacct gttcgacgcg gtgcccccgc cggtgccggt gccgcggcgg     65640
     ttcgcctccg accgggagcg ggccgtgctg gtcatggagc ggctcacggg agaggtgctg     65700
     gcgccggacc ggttcccggt cactccggtc tcccgggagg acctggccgg ggtgctggag     65760
     gccgtggagc ggctgcggca ctggcggccc gcggcggccg gcgcgtgggc ggtggactac     65820
     cgggggatgc tggagggggt gcacgcccag ggcgtcttcg acgacgggca ctgggcggac     65880
     ctgctccggc tcctcgaact gtccggtgcg ccccgcgagt tcggccacgg cgacctggtg     65940
     ctggcgaacg tggtccgcag ccggggccgg caggtcctga tcgactgggc gagcagcgcc     66000
     ctgtacctgc ccggactcga cctggcccag ctctggatgc tcctcggcga cgtccccggg     66060
     gcgcgggccc gcatcgaggt ggaggtggcc gaccgcgccg acgaccggga cgggatgatg     66120
     ccgttcctgg tgaacctgac gctgctgctg taccgcgagc gccgcgccca ccggcggttc     66180
     accgacgacg cctcgcgggc ccgggcggtg gggctcgacg ccgcctggga gctgacccgg     66240
     caccgcgtcc ggcagtgcct ggcgacggcc ggctgaccgg cccggcgcac acgaaggggc     66300
     ctcccggtga agtgcgccgg gaggcccctt cgtgtggggg gggaaggcgg tctactggat     66360
     gagcagttgg tggctggcca gctcccggta gagggggctg gtgccggtga gttcctcgtg     66420
     ccggcccgcg gcgacgaccc ggccgtgctc caggacgacg atctggtcgc tgtccacgac     66480
     ggtggacagc cggtgggcga ccacgagcag cgtccggtcg gcggtgacgg tgccgatggc     66540
     ctcccgcatc agggcctcgt tgcgggcgtc gaggttgctg gtcgcctcgt cgagcagcat     66600
     gatcggcggc gcggccagga aggtgcgggc cagcgccagg cgctgccgtt cgccgccgga     66660
     cagcaggacg ccgccctcgc cgacctcggt gtccaggccc tgcggcgccc gctcgatcac     66720
     gcccatgagg ttgaccgagc gcagcacctc ccgcatgtcg tcgtcggtgg cgtcgggcgc     66780
     ggcgagggag aggttgtcgc ggacggtgcc ggcgaggacc ggcgccgact gctcgacgta     66840
     gccgaggcgt ccgcgcagtt cgcggcgggg caggtcgcgt acgtcggtgc cgccgacccg     66900
     gacggtgccg gaggtgacgt cgtagaaccg ttccaccagc gacaggaggg tggacttgcc     66960
     cgctccggag gggccgacga gcgcggtgcg ggtgccgcgg gggacggcga gggagacgtc     67020
     ccgcaggacc gtctcgccgt cgccgtagcc gaagctgacg ccctcgaact cgatcgcggg     67080
     cggccgcggt tccgcgtcgg cgggctcggt cccgggccgg gtgcgttcgc gcaccgtgag     67140
     cggtcccgcg acggcgtcgg tctcctgcgg caggtccacc atctcctcga tgcgctggag     67200
     ggcgcccagc ccggactgga gccgggagta ggcggtcagc gcgcggccga gcgggaacca     67260
     cagcatgaac aggaagagca cgaaggcgac catgtcgccg acctggatgg cgccgctggc     67320
     cacccgggcg ccgccgaggc cgaggacgac gaggaacgcc acctggatgg tggtcgaggt     67380
     gatcgggttg atcatcgcct ggagccgggc gatgcgcatc ccggcgtggt aggcctgctg     67440
     cgcgtacccg tcgacggcct tgccctcgcg ttcctcggcg ccgctggcgc ggatggtgcg     67500
     cacggcggag atggcgcgct cgacggcgga ggtcatctcg ccgatccggt cctgggcgtc     67560
     gcgggaggcg ccccgcaccc gccgggagag cccgacgacg gcgaggacgc cgagtccgag     67620
     gccgagggcg gtggccgcga acagggtggg gtcgatcagg cacatcatga gcgcggagcc     67680
     gccgaccatg acgacgttgg tcacggtgtc gaagaggccg gaggtgacca ccgcgcgcag     67740
     catggtggtg tcggcgccga cccgggagag catgtcgccg gtgcggcgct ggtcgtactc     67800
     ggtgatgggc agccgcagca gccgggccac cagccggcgg cgggcggtca gcacgagccc     67860
     ttcggcggcc cgctggagca ggtagtcgcg gaccccgccg agcacggcca ccaccacgag     67920
     gacgccgatg agcagggcca ccagccgccc caccggcctg tccgcctcga tgtcggccag     67980
     tacgtcccgg gtcagcaccg gctggctgag ggtcagcagg gtgaccacca gggagagcac     68040
     cgcgacgatc cccagcgtcg gccagtagcc ctggagatag gggaacaggg agcgcagccc     68100
     gaccttgcgg accggcgggg cgggcggtcc gggctccggc gcgttcttcg cgccggtctt     68160
     ccgggcgggc ggtcgctccc tggtctgcgt gctcgtcatc gcactcctac tcatgtctca     68220
     ctgcgggggc ttggccggtc aggcgggctg cggggccgct ccgagcacgt agccgtcggc     68280
     cggccgcatc gcgcgcgagc ggcgcaggtc ggtgagcacg aaggtgcgct ggagccagcg     68340
     gtcggtgccg tcgtagcggg gggtgaactc ggtgcggccg tgcacggtga cgcggttgtc     68400
     cacgatcgcc agctccccgg gcaggaggcg gtgggtgacg gcggtggcgt cgaagtgggc     68460
     ctggagttcg cgcagggcct cggcggcccg ctcggtcacc ggctcggtgg ccgccaggtc     68520
     cacccgcagg tcggggtccg aacggtcgcc gaggagtacc ggtgcgggtg cctcctcggg     68580
     gccgctcagc tggaaggagg gcggcggcgc ggtgcggaac tccggtgccc acagggcgtc     68640
     cacggtggag tcggacagca gcggcagcac ccgccgcacg cacgcggtgc gcaggcccgc     68700
     ccggcccgtg gggtcggcgc gcaggcacag cagcatcacg aagtcggggc ggtgctcgtg     68760
     gaaggcgttc tcgttgtgga acgtcagcag ggtcgaaccg gcgttgccct ggaactcctc     68820
     catgcccggc acggggacga cgtcctgtac gagggcgccg ttcttctccg gcaggaacgc     68880
     gccggggtcg ccgagcccgc aggcggtcat cagcagcacg gcggcgccca gcgaggcctc     68940
     gcgctgcacg gagccgttga cccgcggggt cggcggcagc cccatggagt cgacgggcag     69000
     accgcgcagc acgatcgcgc cgtccggtcc cgagtcccgg cggaatccgg cgaggtcccg     69060
     gcgcagggtc gccggccagg cgtgccaggc gttcctggcc gcctcgaccc attcggcgtc     69120
     gtcgggccgc ccggtcgcct gcgtggcgag tttccaggcg atctcctcga cgagttccgc     69180
     atccgactga tccagcgtca cgtcgtagcg cgacgccggt cccgcggcat tcgcagccat     69240
     gggcagagcc tccgtccacc gtcgttttgt gtgtactcgg gacgctatgg gccgtcgtta     69300
     tcggccgcgt atcgagtgag catggggaga gatcccggcc agggagagca gcagttcctt     69360
     gacctccgtc gcggcgacca actcccccag cggcgcgtcc gggtcggaga ccagcagcac     69420
     cggcgcgtcc tcggggcggc cgggcaggcg tccgtggctg ccgcggaccc gggagccgtc     69480
     cagggggacg acgttcatgg tgtagcgcag cccgagcttc ttgcgggcca gcgccgccgc     69540
     cgcgcggagc cgggccttcg ccggggcgtg gtggtcgaag cccagctcgg ccgggtcgta     69600
     gccgggcttg cggtggatct cgacggtgcg ggcgaagtcc ggggcgcggg cgtcgtccag     69660
     ccagtagtag taggtgaacc aggcctcggg ccgggcgacg gcgacgagtt caccggcccg     69720
     ctcgtggtcg aggccgtgtt ccttcttccc ggcctcgccg agcacctcgg cgacgccgtc     69780
     caggccgtgc agcagttcct cgacgcgcgg caggtcggcg gcgtcgcgca cgtagacgtg     69840
     ggcgacctgg tggtcggcga cggcgaaggc cctcgacgtc caggggtcca ggtactccat     69900
     gccgtcctgg gtgtgcacgg ccagcagccc ggcccggcgc agcgcccggt tgatgtcgac     69960
     gggcctgctg accggggtga tgccgtactc gctcagcacc acgacggtga cgccgtcgcg     70020
     gcgggcctcg tcgagcagcg gtgccagggt gcggtccagt tcggcggcgg cccggcgggc     70080
     ccggcggctg tccgggccga agcgctggag gtcgtagtcg aggtgcggca cgtagacgag     70140
     gttcaggtcg ggcttgtggg cgcggtgcag atggcgggcc gcgtcgacga tccagcggga     70200
     ggaggcgagg tccgcggtgg gcccccagta gtggaagagc ggaaagggcc cgaggcggcc     70260
     ggtcagctcg tcgtgcaggg aggccgggtg ggtgtagcag tcgggctcct tgcggccgtc     70320
     ggcgtagtag accggccggg gcgtcaccgt ccagtcgacg tcggcgccca tggcgtacca     70380
     ccagcagacg ttggcgacgg tgtagccggg gtgcagcgcg cgggccgcct gccacacctt     70440
     ctcgccgccg acgagccggt tgtgctgccg ccacagcagt acctcgccca ggtcgcggaa     70500
     gtaccagccg ttgccgacga cgccgtgctc cgcgggcggc cggccggtca gcagcgtgga     70560
     ctgcaccgag caggtcacgg cgggcagcac ggtgtccagg cgggcgccgg tgccggcgtc     70620
     gcgcagcgcc gagaggcggg gcatgtgggc cagcaggcgc ggggtgagcc ccacgacgtc     70680
     cagcacgagc aggcgcttca cggggtgctc tcctccgtca ggccgagggc ggtcagggcg     70740
     gagcgggtcc aggcgagttc accggcgatg ccgtcgacga ggccgccgcc gtcgggtgcg     70800
     ccgggcagca ccggccaggt gtaggtctcg acctccacgt ggtcggtgag cgcggtcggc     70860
     ccgccgagca gggtggtcag cgcggcgacc agttcggggc gggtgctgcg caggggcggc     70920
     ggcaggtcgc gctggacggg cacgtggtag tggatccgcc aggccgcgtc gccgttcagc     70980
     gcgcccccaa gcgcctcggg caggtcgtcg acggccgacg ggccgcccgg cgcggcctgc     71040
     cgcgtctggt gcaggaaccg ccgctcggcg aaggcggcca gcgcggcgcg ggcggccggg     71100
     tcggccggcc ggtcggcgtg caccgcgcag gacgcctggg tcttgacgac gggcagcgcg     71160
     gcggccagcc gggtcagcgc gggtcccggc tcctcgaagg cgacggcgag gtggcaggtg     71220
     tcgacgcaga cgccgagccg ttcggggtcc gcgccggcga gccgtgccac cgcctggccg     71280
     gtcgtctcga tcaggcaccc gggctcgggt tcgaacccga cgcgcacggt gcgcccggtg     71340
     tccgcgttga gcgccgccag cccctgggag agcaggtcga ggtggcgccg ggcgaggtcg     71400
     tcccggcgcg gggtccaggg tgtgcgccag gccagtggca gcgtggagac ggagccgcgg     71460
     gcggcgtccg gcggcagcag ctcggccagg acgcgggcgc aggccagggt gtggtcgagg     71520
     cggggccgct cggtccagtc gggccggtag acggccttct tgacggtcgg ggcgtggaag     71580
     cccgcgtagg ggaaggcgtt gagggtgacg acctcgatgc cgcgcaggtc cagttccttg     71640
     cggagcaggt cgagcgcgga ccggtccgcg gccagggccg tcacgaccgg tgccgccagc     71700
     cacagtccga ggccgatccg gtcggcgccg agccgttcgc gcaccggctc cccgtagcgg     71760
     gccagctggg ccaggacgcc gtcgaggtcc tcggccgcgt ggacgttggt gcagtaggcg     71820
     aggtggacgg tggtgccgtc gcggtgccgc aggcgcacgg cccgtcacct ctccccgcgg     71880
     cggatcgagc tgccctcgaa ctccgcgcgg acgccggagg cttcggcgcc ctcggggccg     71940
     tcgagttcga ggcgcccgct ctgcccgtag aaggcgaccg gattgcgcca cagcacctgg     72000
     tcgacgtcgt cctcgccgaa gccggcggcg cgcatggcgt cggcggtgcg gcgggtcttc     72060
     agcgggtcgc tgcggcccca gtcggcggcg gagttgacga ggatccgcgc ggtgccgtac     72120
     tcgcgcagca gcgcgaccat gcggtcctcg ctcatcttgg tgtcggggta gatcgagaaa     72180
     cccatccagc agccgctgtc cgcgacggcg cgcacggtca cctcgttgag gtggtcgacg     72240
     acgaccaggc ccgggtcgat gccggactcg cggaccacgt ccagggtgcg gcgggtgccg     72300
     ttggccttgt cgcggtgcgg ggtgtgcacc aggacgggca gggcgtgccg cacggcgagt     72360
     tcgagctgca cggtgaacgc cttgtcctcc tgcggcgtca tcgcgtcgta gccgacctcg     72420
     ccgaccgcca ccacccggtc ccggaccagg tagtcgggca ggacgtcgag caccccggcc     72480
     agccgggggt cgttggcctc cttggggttc agggcgagcg cgcagtggtg gcggatgccg     72540
     aactgctcgg cccggtaggg ctcccagccg agcagcgcgt cgaagtagtc ggtgaacgag     72600
     ctgacgccgg tgcgcggctg gcccagccag aaggcgggtt cgaccagcgc gcggaccccg     72660
     gcggcggcca tcgcctcgta gtcgtcggtg gtgcgggacg tcatgtggat gtgcgggtcg     72720
     aagatgcgcg tcacgccgtg gcctccgtgg atacgcggtg ggtgtgcagg taggcggcga     72780
     cgtcgggcgg gagtgcccgt cccgcggcgc gccgctcggc ggcgaagtcg gccatcatcc     72840
     ggtccagttc cgcgtcggcg cgtgcgtcca gcgcggccac caggtccagc gggacgccga     72900
     cgaacacgca tttgaggacg gcctgccgga aggcgtgcgc accgagccgg cgggcgccgt     72960
     acgggccgac ggcggcggcg atcagcctcg ggtcgttgca ccgcagcgcg tcctcgacca     73020
     gcggcagccc caggtccccg aggtcgcccg cggcctccag cagcgacagc gaccgcagga     73080
     cggcccgccg ttcgggcccg cccccgatcc ggtacagccg ggagacgacg gccgccagcg     73140
     cggcaccgcg caccggaagc gcggcgagca gcagcacgcg cgcggcgtcg tcgacgctcc     73200
     accccgcgcc cagccccgta cccgcatccg cacccgcgcc cgcttccgcg ccggcgtcga     73260
     gcgcgccccg accgcaccgc cgggcggcga ccgcgaacgt cccctcgacc tcgcccggct     73320
     cgcaccgcac cgccgcgcac gcctgctcca gccacgcggc ggcgtccggg gcgagcgcgc     73380
     ggtccagggc gccggcgagg gcgtccggca gggaccgggg tccgtcgccg ccggggttca     73440
     cgcggccgct ccccgggtcg cggggcgggc gccggcgtcg gccgcgcgca ggaagtccag     73500
     ggaccggcgg gccacctcgg gggcggcgtg gctgtgccgg ggcagctcca ccgagaccag     73560
     tccgcggtag ccggtggcgg ccagcgcgga cagcacgggc gggaagtcga tctccccgct     73620
     gccgaactcc aggtgctcgt gggtgccccg gcgcatgtcc tcgatctgca cgttgaccag     73680
     ccggtcggcg acccgccgta cgcagtcggc gaccggctgc ggctccaggc agcggcagtg     73740
     cccgatgtcc agggtcagcc ccagcgggtg cgggccgccg agcctgcggc acagttcgtc     73800
     gtaggcgtcc agggtgtcca cgaacatgcc gggctccggt tcgaagccca gcacgacccc     73860
     ggcccgcgcg gcggcctcga cgacggtgcc gcagccggcc agcagccggt cccagaccac     73920
     ctgccggggc gtgtcggcgg gggcggcgcc gctccagaag gacacggcct ccgcgccgag     73980
     gtcggcggcg atccgcacgg cccgcagcag caggtcgacc cggcgcccgg cgccctcggc     74040
     ggacatcagc accggctggt gcttgcgcca ggggtcgagc acgtaccgcc cgccggtctc     74100
     gacgacgacg gccagcccca gccggtccag ccgcgccgcg agccgccgca gccggtgcgg     74160
     caggtcgtcg gcgaacgggt cgaggtgccg cgggtccagg gtgagtccga cgccctcgta     74220
     gcccagatcc gcgaggacgg ccagggcgtc ctccagcgga tggtcgccga agccgttggt     74280
     gccgtacccg aatctcgtac cggcgctcat gtgggggaca cctttctgcc cagtcgtcgg     74340
     gcccacggga gggcgcaggc cagcgcggcg ccggcggcgc cgcgtccggc ggtcgcggtc     74400
     agcgccgcct ggagcgggat cagcgcgtgg atgccggccg ccaccgcccg ccgcacctgc     74460
     ggcgcggccg gactccgcgc ggccgcgagc tgcgccgccg cacccccgta cgcgtacacg     74520
     gccgtcaggc ccgcggccag gacccggtcc cgggccggcc gacggcggcc gcgcagcagt     74580
     acggcggctc cgaccgcccc gccgacggcg agcgactgcc ggggcaccgc gcggggcgca     74640
     ccgctcacct cgtaccggct cagccgggtg accatgccgg tgtgcagggc gacggtggcc     74700
     gccgccggca gcgcccggcg cagtccgccc ggtcccgcgc cgcccaggac gttcagcgcg     74760
     cgggccgcgg ccatcgcggc cgcaccggcc ggggtgggct tgagcacgag gtcgtacgcc     74820
     cagacgacac cggccagggg cagcgccgtg gccaggcccc ggcggccgcg ggacagtgcc     74880
     gcgaggccga gcccggccgc ggtgagcccg cagccgaccg cgcgggccgc ggccgggctc     74940
     accgccccgg agggcaccgg gcgttcgggc cgctccaccg cgtcgaggtc gcggtccgcg     75000
     tagtcgttga gcgccatccc cgcccagtac aggcagaccg acgaggccgt catgccgagc     75060
     agtccggggc cgagcggccg ccgggccgcc gccgctccgg cgaggacgtc cccgggcacc     75120
     gacagcgcgg ccggggcccg gaccaggcgg gccaggtcgt gcacccgcgg cagcgcactc     75180
     acgcgggcgc ccccaccgag cgcgcccagg cggccaggct cgcgtactgc gcggccaggt     75240
     cgtgctcggc ggagcccacc gggtccttga agaagaagcc cagctccggc accggcccgg     75300
     cgacgcctgc gcggtgcgcg agggccatga accgggccag gtccagcacg agcggcgcgg     75360
     ccagcgagga gtcgcagccc tgccacgtga actgaagggt catccgggcc ccgaggaacc     75420
     cctcgaacgt cacgtggtcc caggcggtct tccactcccc gaggtcggga acgtggtgga     75480
     tgtgcacgcc gccctcgacg gcgtggccca gctccgcctc cagcaccagg cccttggagg     75540
     cgttcttgct gaccacccgc tccgggtcgg cgagggtggc cccgtcgccg ccgcccagca     75600
     ggttggtgcc ggaccaggag cgcacccgca gcgcccggcg cgcgaacatc ggcgcgagca     75660
     ccgacttgac cagggtctcg ccggtcttgc cgtcgctgcc ggcgtagggc aggccctgtt     75720
     cccgggcgag ttcgtccagc gcgggcaggc gcgctcccgt cgacggggtg aagtcgacga     75780
     aggcgcagcc ggcccgcagc gccgcgtagg cgtacaggga gctgacgggc agcggccgtt     75840
     cgccccgcgc cagcgcctcg cgcagggccg ccgccgaggc gtgcgccggg tgcggcacgg     75900
     ccggcggctg ggtggaggag acgttcacga cgacgacccg gtccagaccg aggcgctccc     75960
     ggaagccggt gaggtcggcg acgatcgccc cggcggccga cgcctggtcc ggggtgccgt     76020
     cgccgccctc ctccgtgccc ggcggcgcgg gcctgatctc ggcgtcggcc gcgtcgagtt     76080
     ccgcggtcag cacacccggc aggccgcggg gcacgacgcc cgcctcggcg agctgctcgg     76140
     cccgtttgac caggccggtg ccgacgacgt cgtggccgcc gaagaccagc tcgtcgaagc     76200
     cgggcagcgg cacgccgtcg aaggcctcga gcgcgctcac acagccggtg gccggcacca     76260
     gcccggcgcg cagcgcggcg gcgccgacga cggtcgtggt ggccaccgag ccgcgggcac     76320
     ccaccagcca gattccggta cgcatgatgt ctcctcctgt ccttgccgtt gtcctcgccg     76380
     cggcgccggg tccgtcagct catgccttcg ggcagcgggt aggacaggaa gtcgcggtcg     76440
     agccggtgca cgctgcgcgg cagccacttg gcggcctccc gggccacgac ccggcgcggc     76500
     agcggctcct tgacctcgaa ctgggagggc ttggcgatgg tctggatcgc ccacgccatc     76560
     gcgttgatcg gggccatccg ctcccagcgg tgcctgctga tgtccagcag catcatcgac     76620
     cgcatgaaga tgaaccagat gtggtagccg ggcggcgggt tgccgttcat ggtgtgcacc     76680
     gggcgctcgc ggcgggggtc gttgagcacg ccctgggcga agtccgcgaa ggcgccgacg     76740
     atgccgtggc cgtagggccg gtagtaggtg tcgaagacgc cgagctgggc cttggagagc     76800
     acctggagcg ggcccttgat gggggtgacg tactcgatga agttgttcgg gtagtcgctg     76860
     gtggcggcca tggccatcca ggcgtcgaag atggcccgct cccagccgtc gccgagcgcg     76920
     gtctcgatgt cggtgaacgc ctgctccagc tccgggccca cgttgtagag cgtggtctcg     76980
     tcgaacatgt accagagttc gttggcgcgg cggtcgccga gcatgccggg tacgtcgggg     77040
     aagtcgtcgt ggccgcggtg cggggtgacg gggcgctcgg cggcaccggc cggagcggcg     77100
     cccagcagac cggcgccggc gccgaggccg acggccgcgg caccgccgag ggcggtggtc     77160
     atcaggcgcc gccggtcgag gtggttcgac atgggttctc cttggttctc tcgcgcgggc     77220
     agggtgggct cgggggtggg ttcagggggt cgcggcgggc tacggcggcg gcagcggtgg     77280
     gaggccggcc tcggcgtcgt ggcgctggat ccaggacacg tcctcgacga gggacgacat     77340
     cgtgcccgtg gactcggtcc cgtcctcgtc gggccgcagc cgctgggagc cgccgccccg     77400
     cgagccgagt tggacccggg tggtgtgcgg cctgcggaca ccctcgtagg cgtccagcgc     77460
     ggccgcgatc gcccgccggg cggcgggagc ggaagcggcg gctgcggcgg gagcggaggc     77520
     ggcggctgcg gcggatacgg aggccgaggg gtccgggccc gtcggggcgt ccaggcagtg     77580
     tgcgaggacc gccgcgtcct cgacggcctg gctgacgccc tggccgtggt ggggcagcat     77640
     cgggtgggcc gcgtcgccga gcagggtgac ggcgcccgcg ctccagcggg ccagcggctc     77700
     acggtcgtac agcgcccagc gccgggactc ccgcaccgcg gccaccaggg acttgacgtc     77760
     ggtgttccag ccgtcgaagc gggcggccag ttcgtccagg tcgcccgggg cgctccagga     77820
     ctccaggcgc caccgcgggt cgggcacgac ggcgacgaag gtgaggaacc gcccgccgcg     77880
     caccgggtag accagcatgc gggcgtccgg tcccgcccac accaggagcg tgtcaccggg     77940
     caggccggga acctggtcgc gggcgacgac gccgcggaag gcgctctggc cggagaagac     78000
     ggcggtgtcg ggcccggcga gggtgcggcg caccacggag tgcgccccgt ccgcgccgat     78060
     caggacgtcc gcgccggcgg tggagccgtc ggcgaactcc agccggaccc cgcccccggt     78120
     ctcggtgaac cgttcgagcc ggtgcccggc ccgcaccgtg ccggagggca gcgactcggc     78180
     gagcatggtg tgcaggtcgg cccggtggat cgtgtagtac ggcgccccga actcggcgag     78240
     ccattcctcg cccatcggct gccgcaccag ggtgcccccg tgcgaccagt cccgcacctc     78300
     catgcccgcg ggccgtacac cgagggcgcg cagccgctcg ccgaggcccc agcgttccag     78360
     aaggcggctg ccgttggggc ccaggtgcat gcccacgccc gcttccctga gttccggcgc     78420
     ctgctcgtag acgcgtacct cgtggccctt ccgggtcagg gcgagggcgg cggcgagtcc     78480
     gccgatgccc ccgccgacga ctgcgatccg cagcttcggc accacgttgt cccttcctct     78540
     cgtgcgcctg gttcgtcgct cggtccggtc agctccgctg gtcctggacg ggttccgcgc     78600
     ccgaccagac gacggcggcg gagccccagg tcagcccgcc gccgaaggcg gtcaggagca     78660
     ggcggtcccc ggagccgata cggccctgcg cggccgcgtc ggccagcgcg agggggatgg     78720
     acgcggcggc ggtgttggcc acgtccgcga tgttcgacac cacccgctcc gggggcagcc     78780
     gcagccgctt cgccaccgag gtgaggatgc ggaggttcgc ctggtgcccg acgaaggcgt     78840
     ccacgtccgc caggtcccag cccgcgtgcg cggcggtgga acgcgccgac tccgccatgg     78900
     tggtcacggc acgggtgtag acgtcgctgc cgcgcatggt gaggtacgcg ccgtccggcg     78960
     ggatggtgat cagctcgtcg ccggtgccgt cgctgccgag ctcggtgtgc agcacggcgc     79020
     ccgggtcgcc ggtgtcgccg cgctccagga gcacggcgcc cgcgccgtcg ccgaagacga     79080
     cggcggtgcc ccggtcgtcg gggtccacga tcgaggagta gacgtccgcg ccgatgacca     79140
     gggcccggtc gcaggtgccc gcggtgatca tcgcgctggc cacggacagc ccgtacacga     79200
     agccggagca cacggcggac aggtcgaacg cggcggcggc ccgcagcccg agccgggacg     79260
     ccacccgggg cgcggtggcg gggcagcgcc ggtccggtgt ggtggtggcg aggaggacga     79320
     ggtcgcagtc gtcccgtccg gcggacttca gcgcggcggc cccggcggtg acggcgaggt     79380
     cccccgtggt ggtcccgggc gacacccggc gccggcgctc gatgccggta cggctgtgga     79440
     tccaggcgtg gtcggtgtcc aggtgccgcg acacctcgtc gttgtcgacc acggtctccg     79500
     gcagacaggt gcccaccccg gtgacgacgg ccccggcccg accgccgcgc gcggcgctca     79560
     cgggcgtact ccggcctgca cggtgccggg ggcctgcacg gtgcccgggg ccggtccggt     79620
     acccgggctc ggtccggtac ccgggctcgg gacggtgccg gcatgggccg cggcggtgcc     79680
     ggcatgggcc gcggcggcgt gccgttccgc gaagtccggg tgggcgatcg gggcgctgat     79740
     caggccctcg ggcacggcca gttcgcgcag cagcgcgtcg gcgtcgaggg gggcgcccgc     79800
     cgcctcgtgc cgggccgcct cgaaccccag gagggcgtcc tggtcgagga tcccggcccg     79860
     cagggcggcc agcgcgtgtt ccagcacgca gaccgccgcg tactgcgcga gcagccgctc     79920
     ggacagcggg gtcgatgcct gccgggccca gtggccgatc gccagcgtct ggtggacggc     79980
     acggctccac tgcgcgctgg cctcaccggc gccgtcccgc tccacccggt cgagcaggac     80040
     gtcgcagacg gcccgcagca cccggacggc gtccagccgt ccggccccgg cgaccgcctc     80100
     gtccagcacc cggtcgaagt cctcgcggtg gcgcagggcg aaccgggtcg cctggtagcc     80160
     gaggacggtg ttgtcaccgc cgaaggtgac cgcgatctcg tagtcgtgca gcagcggcgc     80220
     gatctggttg gcgtcgtggt agccgagccc gccgcacagc tcccgggtct cggccagcgt     80280
     ttgccgggcg tcgccggtgc agccggactt gccgcacgag atcagggcgt gcagcacctg     80340
     gtcgcgggcc ggtgctccct cggcgctccg ggccaccgcc acctcggcca gcgccgtcat     80400
     ggcgtgccgg gcggccagcg agcgccccac ggccgccgac agccgcatgc ggtagtgctc     80460
     gtggccgatc agcggcctgc cgaaggtctg cttgacggcc gcgaaccgcg tggtgatcgt     80520
     gcaggcgagc agttgcgcgt acgccgctcc caccgacggg aaaagccgct cgtgggtgaa     80580
     ggtggccagg cactcctcga accgccggtg gcgcggcagc ggggaccggt aggtgccgtc     80640
     ctcgtcgatc gacgcccagc ggttcatcag cgcggacagc ggcagccggt ggtccgtgaa     80700
     ggtcagtacg ccggtctggt tggccgtgac accgcccttc ggctcggccc ggccgatgcg     80760
     cacgccgggc agtacggccc cggcctcgcg cagcggtacc cgcagccagt ggtgtccctc     80820
     gtcgcgcccg ccgacctcca gccgggccag caccatggcc acgtcgccgg tgtgcaggct     80880
     gttgccggtc cacaccttgc tgtcggcggg ccggggcgtg ttcagcacca ggctccgccc     80940
     gtgcgggtcg tagaccgcgg tggtccgcac ccgcttcagg tccgagccgg cgaggagttc     81000
     ggaaccggcg aagcagtaca tccgctccat cgcgtcgatc tccccagccc aggcgtccag     81060
     ttgctccgga ccgccgtggc tgagcagcgc gtcgcccgcg atctggtgcg agaccaggac     81120
     gttgagcagg gacaggtcgt acgcgccgat ccagcccatg gtgcgcagga actccgggaa     81180
     gcgggcactg tcgccccggc ccagccagag ggagttcgcc gcgaaaccgg cgccgttgag     81240
     gagccgcgcc cggcgcagcg tcagcaggct gtagtcgagg acgctcaggt cgtccggtcg     81300
     gatggtggcg aactcgggcc cggagaggac acgggccagc tcttcttcgc gttgcgtcat     81360
     gggctctcca ggggagggaa gctcggatcc gtggacgccg tggcgtcgtt cagccggcgt     81420
     ccagcaccag cgcgcagttg ctgccgccga acccgaagga ggtgctcacg gcgacgttcc     81480
     cgtcgtgccg gcgcaccccg ccgaggacca ggtccagctc gggcaggccg gggtcggccc     81540
     gctcggtgtg cgcgatcggc ggcagcacgc cggtgcgcag gctgcgcagg gtcagtacgg     81600
     cctcgatggc gcccgccgcg ccgagcgtgt ggcccagcag gcccttgttc gcggtgacgg     81660
     acgggccgtg cgggaagagg cgggcgatga gccgggcctc cgtcaggtcg ttctgcgggg     81720
     tcgaggtgcc gtgcgcgttg acggtggtca cgttccgcac cgacatccgc gccgccgcca     81780
     gcgcccgctc cacggcggcc gcggcgcccg caccgtccgg ccggggggcc gtcggatgat     81840
     gcgcgtcgga ggtgtcggca tgcccgagca gccgccccag cacctccgct ccccgcgccc     81900
     gcgccttggc cggcttctcc atgacgacgg cggcggcacc ctccgacatc acgaagccgt     81960
     cgcggtcggc gccgaacggc cgggaggcgt cggtcgcctt ctgttcggac agcgcgccca     82020
     tccgggcgaa gccggagacg acgagggggg tgacggccgc gtccgtgccg cagacgacga     82080
     ccgtgtcgca gacaccggcg tccagcagcg tcttgccgag cccgaacgcc gaggcccccg     82140
     aggcacaggc ggcggccacg gtgtgaccgg gcccggtgat cccgtaccgg gcgccgatgg     82200
     tcccggccgc catgttgatc agggcccggg ggtgcaggta cggcgacacc atggccgccc     82260
     cctgccgctc cagccgccgg tgctgctcgt cgtgcgtggt cacgcccccg aaggcgctgc     82320
     ccacgacgac cccgacccgg ctgccgtccc agctgtccgg gtcgagcccc gactgcgcca     82380
     gcgcctccgc cacggccacc agcgcgaacc ggatgaacgg atcggtacgg gcggtcccgc     82440
     gcccggtcag ctgccccggc cgcagcgcgg gcacccgcag gctgtgccac gccccggtcc     82500
     cggccagcgg ctcggggtca ccgccctcca gggaccgggc tgcgcacatc gcctcccagg     82560
     tcgagtcggc gtcggtaccg gccggcgtca ccagcccgac accggtgatg gcggcgggcc     82620
     cctcggtcac gccgcttcca gacccgagcc ggccagcagg accacttccc cgacggtgag     82680
     atccgcgatc cgcgtctcgt caccgctgag gtccacgccg gtctcctcct tgatccgcac     82740
     gatcagctcg gcgacggcca gcgagtccag ctccaggttc cgcagcgagg caccgtccgt     82800
     gatctccgcg gggtccactt ccagatcctc ggccagaatc ccgtgcacaa ccgacttggg     82860
     gtccgtactc at                                                         82872
//