BGC0000319 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0000319 (Streptomyces clavuligerus)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	NRPS	1	34,452	cephamycin C	NRPS:Type I	100%

BGC0000319 - Region 1 - NRPS

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Location: 1 - 34,452 nt. (total: 34,452 nt) Show pHMM detection rules used

Region on contig edge.

NRPS: cds(Condensation and (AMP-binding or A-OX))

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

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Gene details

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Gene overview

MIBiG

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 34,453
Label		BGC0000319

Detailed domain annotation

Selected features only

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Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000319	1.00	NRP	cephamycin C	Streptomyces clavuligerus ATCC 27064
BGC0000820	0.33	Alkaloid	physostigmine	Streptomyces griseofuscus
BGC0001488	0.28	Other	4-formylaminooxyvinylglycine	Pseudomonas fluorescens WH6
BGC0002208	0.28	NRP	oxepinamide F	Aspergillus ustus
BGC0001561	0.27	NRP	curacomycin	Streptomyces curacoi
BGC0001825	0.27	NRP	xenematide	Xenorhabdus nematophila AN6/1
BGC0001261	0.27	NRP	AM-toxin	Alternaria alternata
BGC0001132	0.27	NRP	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0001545	0.26	NRP	chrysogine	Fusarium graminearum PH-1
BGC0000313	0.26	NRP	beauvericin	Beauveria bassiana

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000319	1.00	NRP	cephamycin C	Streptomyces clavuligerus ATCC 27064
BGC0000820	0.66	Alkaloid	physostigmine	Streptomyces griseofuscus
BGC0001488	0.62	Other	4-formylaminooxyvinylglycine	Pseudomonas fluorescens WH6
BGC0002208	0.61	NRP	oxepinamide F	Aspergillus ustus
BGC0001561	0.61	NRP	curacomycin	Streptomyces curacoi
BGC0001825	0.61	NRP	xenematide	Xenorhabdus nematophila AN6/1
BGC0001261	0.60	NRP	AM-toxin	Alternaria alternata
BGC0001132	0.60	NRP	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0001545	0.60	NRP	chrysogine	Fusarium graminearum PH-1
BGC0000313	0.59	NRP	beauvericin	Beauveria bassiana

Similar known gene clusters from MIBiG 4.0

Module view

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NRPS/PKS products

NRPS/PKS substrates

Predicted core structure(s)

For candidate cluster 1, location 405 - 34452:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (Aad - Cys - D-Val)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

SSCG_00146

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AMP-binding (239..655): Aad

nrpys: Aad

SVM prediction details:

Predicted physicochemical class:: hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
Large clusters prediction:: Aliphatic chain with H-bond donor (Asp, Asn, Glu, Gln, Aad)
Small clusters prediction:: aad (Aad)
Single AA prediction:: aad (Aad)

Stachelhaus prediction details:

Stachelhaus sequence:: EPRNLVEFVK
Nearest Stachelhaus code(s):: Aad EPRNLVEFVK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

AMP-binding (1367..1774): Cys

nrpys: Cys

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Polar, uncharged (aliphatic with -SH) (Cys)
Small clusters prediction:: Polar, uncharged (aliphatic with -SH) (Cys)
Single AA prediction:: Polar, uncharged (aliphatic with -SH) (Cys)

Stachelhaus prediction details:

Stachelhaus sequence:: DHESDIGITK
Nearest Stachelhaus code(s):: Cys DHESDIGITK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

AMP-binding (2460..2865): Val

nrpys: Val

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
Small clusters prediction:: Aliphatic, branched hydrophobic (Val, Leu, Ile, Abu, Ival)
Single AA prediction:: val (Val)

Stachelhaus prediction details:

Stachelhaus sequence:: DFESLAAVYK
Nearest Stachelhaus code(s):: Val DFESLAAVYK (100% 8Å match)
Stachelhaus code match:: 100% (strong)