BGC0000319: cephamycin C biosynthetic gene cluster from Streptomyces clavuligerus ATCC 27064
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Location: 142,995 - 177,446 nt. (total: 34,452 nt).
This entry is originally from NCBI GenBank DS570624.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
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Gene details
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General
Compounds
Genes
NRP
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0000319
Short description cephamycin C biosynthetic gene cluster from Streptomyces clavuligerus ATCC 27064
Status Minimal annotation: no
A minimal annotation only contains information on the BGC loci and one or more linked chemical product(s)

Completeness: complete
Whether the loci encodes everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRP (Beta-lactam)
Loci NCBI GenBank: DS570624.1
Compounds
  • cephamycin C
Species Streptomyces clavuligerus ATCC 27064 [taxonomy]
References
Chemical products information
cephamycin C
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C16H22N4O9S1
Chemical database entries
NPAtlas
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • SSCG_00130
  • EDY47102.1
 142995 - 143993 (+) beta-lactamase
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  • SSCG_00131
  • EDY47103.1
 144030 - 146111 (-) D-alanyl-D-alanine carboxypeptidase
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  • SSCG_00132
  • EDY47104.1
 146465 - 147934 (-) cephamycin export protein cmcT
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  • SSCG_00133
  • EDY47105.1
 148322 - 149860 (-) aldehyde dehydrogenase
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  • SSCG_00134
  • EDY47106.1
 149876 - 150811 (-) deacetoxycephalosporin C synthetase
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  • SSCG_00135
  • EDY47107.1
 150890 - 152086 (-) isopenicillin N epimerase
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  • SSCG_00136
  • EDY47108.1
 152449 - 152568 (-) hypothetical protein
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  • SSCG_00137
  • EDY47109.1
 152861 - 153571 (+) conserved hypothetical protein
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  • SSCG_00138
  • EDY47110.1
 153620 - 154552 (+) 7-alpha-cephem-methoxylase P8 chain
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  • SSCG_00139
  • EDY47111.1
 154649 - 155605 (+) deacetoxycephalosporin C hydroxylase
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  • SSCG_00140
  • EDY47112.1
 155681 - 157246 (+) 3'-hydroxymethylcephem-O-carbamoyltransferase
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  • SSCG_00141
  • EDY47113.1
 158162 - 158950 (+) positive regulator
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  • SSCG_00142
  • EDY47114.1
 159019 - 159195 (-) hypothetical protein
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  • SSCG_00143
  • EDY47115.1
 159273 - 160289 (+) secreted protein
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  • SSCG_00144
  • EDY47116.1
 160636 - 161184 (+) BLP
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  • SSCG_00145
  • EDY47117.1
 161790 - 163163 (+) L-lysine-epsilon aminotransferase
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  • SSCG_00146
  • EDY47118.1
 163400 - 174661 (+) N-(5-amino-5-carboxypentanoyl)-L-cysteinyl-D- valine synthase
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  • SSCG_00147
  • EDY47119.1
 174693 - 175682 (+) isopenicillin N synthetase
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  • SSCG_00148
  • EDY47121.1
 175791 - 177446 (-) secreted penicillin binding protein
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NRP-specific information
Subclass Beta-lactam
Cyclic? yes
NRP-synthases
Gene Modules
SSCG_00146
Module 0
Specificity: 2-aminoadipic acid
Evidence for specificity:
  • Activity assay
Module 1
Specificity: cysteine
Evidence for specificity:
  • Activity assay
Condensation domain type: DCL
Module 2
Specificity: valine
Evidence for specificity:
  • Activity assay
Condensation domain type: LCL
Annotation changelog
MIBiG version Submitter Notes
1.0
  • Hidden contributor (ID: SDHXYXULZ6ZTMHSITTYHRAHA, no GDPR consent given).
  • Submitted
2.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Migrated from v1.4
  • Updated compound(s) information (NPAtlas curation)
3.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Corrected NRP module activity
  • Updated NRP substrate specificities
3.1
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Update chemical activity to schema version 2.11
Detailed domain annotation
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