BGC0000320: cereulide biosynthetic gene cluster from Bacillus cereus
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Location: 1 - 35,864 nt. (total: 35,864 nt).
This entry is originally from NCBI GenBank DQ360825.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
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Gene details
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General
Compounds
Genes
NRP
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0000320
Short description cereulide biosynthetic gene cluster from Bacillus cereus
Status Minimal annotation: no
A minimal annotation only contains information on the BGC loci and one or more linked chemical product(s)

Completeness: complete
Whether the loci encodes everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRP (Cyclic depsipeptide)
Loci NCBI GenBank: DQ360825.1
Compounds
  • cereulide
Species Bacillus cereus [taxonomy]
References
Chemical products information
cereulide
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C57H96N6O18
Chemical database entries
NPAtlas
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • ABD14705.1
 278 - 466 (+) hypothetical protein
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  • ABD14706.1
 677 - 1156 (-) CAAX amino terminal protease
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  • ABD14707.1
 1781 - 3091 (+) pXO-14-like conserved protein
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  • ABD14708.1
  • cesH
 3342 - 4151 (+) CesH
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  • ABD14709.1
  • cesP
 5142 - 5897 (+) CesP
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  • ABD14710.1
  • cesT
 6166 - 6879 (+) CesT
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  • ABD14711.1
  • cesA
 6845 - 17020 (+) cesA
  • Scaffold biosynthesis
Activity assay
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  • ABD14712.1
  • cesB
 17034 - 25079 (+) cesB
  • Scaffold biosynthesis
Knock-out
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  • ABD14713.1
  • cesC
 25245 - 26120 (+) CesC
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  • ABD14714.1
  • cesD
 26137 - 26943 (+) CesD
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  • ABD14715.1
 27915 - 28328 (+) pXO-11-like hypothetical protein
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  • ABD14716.1
 29370 - 31298 (+) reverse transcriptase
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  • ABD14717.1
 31554 - 32564 (+) pXO1-10-like hypothetical protein
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  • ABD14718.1
 32879 - >35864 (+) pXO1-8-like hypothetical protein
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NRP-specific information
Subclass Cyclic depsipeptide
Cyclic? yes
NRP-synthases
Gene Modules
cesA
Module 0
Specificity: 2-ketoisocaproic acid
Evidence for specificity:
  • Activity assay
Modification domains: Unknown
Non-canonical activity:
  • Other
Evidence for non-canonical activity:
  • Structure-based inference
Module 1
Specificity: alanine
Evidence for specificity:
  • Sequence-based prediction
Condensation domain type: LCL
Non-canonical activity:
  • Other
Evidence for non-canonical activity:
  • Structure-based inference
Module 2
Condensation domain type: DCL
cesB
Module 2
Specificity: 2-ketoisovaleric acid
Evidence for specificity:
  • Activity assay
Modification domains: Unknown
Non-canonical activity:
  • Other
Evidence for non-canonical activity:
  • Structure-based inference
Module 3
Specificity: valine
Evidence for specificity:
  • Sequence-based prediction
Condensation domain type: LCL
Non-canonical activity:
  • Other
Evidence for non-canonical activity:
  • Structure-based inference
Annotation changelog
MIBiG version Submitter Notes
1.0
  • Hidden contributor (ID: UG4XEFSSWZANFJRHIEGSOCEX, no GDPR consent given).
  • Submitted
2.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Migrated from v1.4
  • Updated compound(s) information (MIBiG Annotathon)
  • Updated compound(s) information (NPAtlas curation)
3.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Corrected NRP module activity
  • Updated NRP substrate specificities
3.1
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Update chemical activity to schema version 2.11
Detailed domain annotation
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