BGC0000320 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0000320 (Bacillus cereus)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	NRPS	1	35,864	cereulide	NRPS:Type I	100%

BGC0000320 - Region 1 - NRPS

Download region GenBank file

Download region SVG

Location: 1 - 35,864 nt. (total: 35,864 nt) Show pHMM detection rules used

Region on contig edge.

NRPS: cds(Condensation and (AMP-binding or A-OX))

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

MIBiG

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 35,865
Label		BGC0000320

Detailed domain annotation

Selected features only

Show module domains

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000320	1.00	NRP	cereulide	Bacillus cereus
BGC0000426	0.42	NRP	sevadicin	Paenibacillus larvae
BGC0001133	0.36	NRP	taxlllaid A	Xenorhabdus bovienii SS-2004
BGC0002071	0.34	NRP	virginiafactin A, virginiafactin B, virginiafactin C, virginiafactin D	Pseudomonas sp. QS1027
BGC0002075	0.31	NRP, Alkaloid	pyreudione A, pyreudione B, pyreudione C, pyreudione D, pyreudione E	Pseudomonas fluorescens
BGC0001341	0.29	NRP	valinomycin	Rothia nasimurium
BGC0000351	0.27	NRP	exochelin	Mycolicibacterium smegmatis MC2 155
BGC0001185	0.27	NRP	bacillibactin	Bacillus velezensis FZB42
BGC0001748	0.27	NRP, Polyketide	pseudospumigin A, pseudospumigin B, pseudospumigin C, pseudospumigin D, pseudospumigin E, pseudospumigin F	Nostoc sp. CENA543
BGC0001890	0.26	NRP	amphi-enterobactin 1, amphi-enterobactin 2, amphi-enterobactin 3, amphi-enterobactin 4	Vibrio campbellii ATCC BAA-1116

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000320	1.00	NRP	cereulide	Bacillus cereus
BGC0000426	0.73	NRP	sevadicin	Paenibacillus larvae
BGC0001133	0.69	NRP	taxlllaid A	Xenorhabdus bovienii SS-2004
BGC0002071	0.68	NRP	virginiafactin A, virginiafactin B, virginiafactin C, virginiafactin D	Pseudomonas sp. QS1027
BGC0002075	0.65	NRP, Alkaloid	pyreudione A, pyreudione B, pyreudione C, pyreudione D, pyreudione E	Pseudomonas fluorescens
BGC0001341	0.63	NRP	valinomycin	Rothia nasimurium
BGC0000351	0.61	NRP	exochelin	Mycolicibacterium smegmatis MC2 155
BGC0001185	0.61	NRP	bacillibactin	Bacillus velezensis FZB42
BGC0001748	0.60	NRP, Polyketide	pseudospumigin A, pseudospumigin B, pseudospumigin C, pseudospumigin D, pseudospumigin E, pseudospumigin F	Nostoc sp. CENA543
BGC0001890	0.59	NRP	amphi-enterobactin 1, amphi-enterobactin 2, amphi-enterobactin 3, amphi-enterobactin 4	Vibrio campbellii ATCC BAA-1116

Similar known gene clusters from MIBiG 4.0

Module view

Legend

NRPS/PKS products

NRPS/PKS substrates

Predicted core structure(s)

For candidate cluster 1, location 0 - 35864:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (X - D-Ala) + (Val)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

cesA

Search NORINE for peptide: strict or relaxed

AMP-binding (126..563): X

nrpys: Kic

SVM prediction details:

Predicted physicochemical class:: N/A
Large clusters prediction:: N/A
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: GICWVGTSGK
Nearest Stachelhaus code(s):: Kic GICWVGTSGK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

AMP-binding (1796..2196): Ala

nrpys: Ala

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: N/A
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DVANIALIYK
Nearest Stachelhaus code(s):: Ala DVANIALIYK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

cesB

Search NORINE for peptide: strict or relaxed

CAL_domain (215..652): pk

minowa: fatty_acid

Prediction, score:

fatty_acid: 26.3
shikimic_acid: 0.0
NH2: 0.0
Acetyl-CoA: 0.0
AHBA: 0.0

AMP-binding (1842..2226): Val

nrpys: Val

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
Small clusters prediction:: Aliphatic, branched hydrophobic (Val, Leu, Ile, Abu, Ival)
Single AA prediction:: val (Val)

Stachelhaus prediction details:

Stachelhaus sequence:: DAFWLGGTFK
Nearest Stachelhaus code(s):: Val DAFWLGGTFK (100% 8Å match)
Stachelhaus code match:: 100% (strong)