BGC0000320: cereulide biosynthetic gene cluster from Bacillus cereus
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Location: 1 - 35,864 nt. (total: 35,864 nt).
This entry is originally from NCBI GenBank DQ360825.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
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Gene details
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General
Compounds
Genes
Biosynthesis
Operons
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0000320
Short description cereulide biosynthetic gene cluster from Bacillus cereus
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: complete
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRPS (Type I)
Loci
DQ360825.1
via Knock-out studies, Enzymatic assays
Compounds
  • cereulide
Species Bacillus cereus [taxonomy]
References
Chemical products information
cereulide Evidence:
Copy SMILES
C57H96N6O18
Chemical database entries
NPAtlas
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • ABD14705.1
 278 - 466 (+) hypothetical protein
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    • ABD14706.1
    		 677 - 1156 (-) CAAX amino terminal protease
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      • ABD14707.1
      		 1781 - 3091 (+) pXO-14-like conserved protein
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        • ABD14708.1
        • cesH
        		 3342 - 4151 (+) CesH
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          • ABD14709.1
          • cesP
          		 5142 - 5897 (+) CesP
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            • ABD14710.1
            • cesT
            		 6166 - 6879 (+) CesT
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              • ABD14711.1
              • cesA
              		 6845 - 17020 (+) cesA
              • Scaffold biosynthesis
              • Activity assay
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              • ABD14712.1
              • cesB
              		 17034 - 25079 (+) cesB
              • Scaffold biosynthesis
              • Knock-out
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              • ABD14713.1
              • cesC
              		 25245 - 26120 (+) CesC
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                • ABD14714.1
                • cesD
                		 26137 - 26943 (+) CesD
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                  • ABD14715.1
                  		 27915 - 28328 (+) pXO-11-like hypothetical protein
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                    • ABD14716.1
                    		 29370 - 31298 (+) reverse transcriptase
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                      • ABD14717.1
                      		 31554 - 32564 (+) pXO1-10-like hypothetical protein
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                        • ABD14718.1
                        		 32879 - >35864 (+) pXO1-8-like hypothetical protein
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                          Biosynthesis information

                          Biosynthetic modules

                          Name
                          0
                          Type
                          nrps-type1
                          Genes
                          cesA
                          Substrates
                          2-ketoisocaproic acid (evidence: Activity assay)
                          Integrated Monomers
                          Domains
                          adenylation
                          Name
                          1
                          Type
                          nrps-type1
                          Genes
                          cesA
                          Substrates
                          alanine (evidence: Sequence-based prediction)
                          Integrated Monomers
                          Domains
                          condensation (LCL), adenylation, epimerase
                          Name
                          2
                          Type
                          nrps-type1
                          Genes
                          cesB
                          Substrates
                          2-ketoisovaleric acid (evidence: Activity assay)
                          Integrated Monomers
                          Domains
                          adenylation
                          Name
                          3
                          Type
                          nrps-type1
                          Genes
                          cesB
                          Substrates
                          valine (evidence: Sequence-based prediction)
                          Integrated Monomers
                          Domains
                          condensation (LCL), adenylation
                          Operons
                          Genes Evidence
                          cesB, cesP, cesT, cesC, cesD, cesARACE
                          Annotation changelog

                          Entry version: 4

                          Date
                          Changes
                          Submitters
                          Reviewers
                          2022-10-07
                          Update chemical activity to schema version 2.11
                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                          Entry version: 3

                          Date
                          Changes
                          Submitters
                          Reviewers
                          2022-09-15
                          Corrected NRP module activity
                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                          2022-09-15
                          Updated NRP substrate specificities
                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                          Entry version: 2

                          Date
                          Changes
                          Submitters
                          Reviewers
                          2019-10-16
                          Migrated from v1.4
                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                          2019-10-16
                          Updated compound(s) information (MIBiG Annotathon)
                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                          2019-10-16
                          Updated compound(s) information (NPAtlas curation)
                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                          Entry version: 1

                          Date
                          Changes
                          Submitters
                          Reviewers
                          2015-06-12
                          Submitted
                          • (ID: UG4XEFSSWZANFJRHIEGSOCEX)
                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                          Detailed domain annotation
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