BGC0000321 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0000321 (Achaetomiella virescens)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 1	NRPS	1	43,979	High	chaetocin	NRPS:Type I

BGC0000321 - Region 1 - NRPS

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Location: 1 - 43,979 nt. (total: 43,979 nt) Show pHMM detection rules used

Region on contig edge.

NRPS: cds(Condensation and (AMP-binding or A-OX) and not alpha_am_amid)

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

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Gene details

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Gene overview

MIBiG

Tailoring

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

NRPS/PKS domains

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 43,980
Label		BGC0000321

Tailoring functions

Oxidoreductases: oxygenase reductase

ctg1_orf003: alkyl hydroperoxide reductase subunit

smcogs: SMCOG1176: alkyl hydroperoxide reductase subunit

ctg1_orf11: cytochrome P450

smcogs: SMCOG1034: cytochrome P450

Transferases: aminotransferase methyltransferase sulfotransferase

ctg1_orf0002: O-methyltransferase

smcogs: SMCOG1042: O-methyltransferase

ctg1_orf12: aminotransferase

smcogs: SMCOG1019: aminotransferase

ctg1_orf6: glutathione S-transferase

smcogs: SMCOG1193: glutathione S-transferase

Ligases: ligase

ctg1_orf10: AMP-dependent synthetase and ligase

smcogs: SMCOG1002: AMP-dependent synthetase and ligase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000321.4	0.94	NRPS	chaetocin	Collariella virescens
BGC0001240.4	0.64	NRPS	serinocyclin A, serinocyclin B	Metarhizium robertsii
BGC0001641.4	0.61	NRPS	kolossin	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001585.3	0.54	other (other)	melinacidin IV	Escovopsis weberi
BGC0000292.4	0.50	NRPS	acetylaranotin	Aspergillus terreus NIH2624
BGC0002226.3	0.48	NRPS	acu-dioxomorpholine B, acu-dioxomorpholine A	Aspergillus aculeatus ATCC 16872
BGC0001609.4	0.46	NRPS	gliovirin	Trichoderma virens Gv29-8
BGC0000372.5	0.43	NRPS	hexadehydroastechrome, terezine-D, astechrome	Aspergillus fumigatus Af293
BGC0001123.5	0.43	NRPS	aspirochlorine	Aspergillus oryzae RIB40
BGC0001841.2	0.42	NRPS, PKS	detoxin P1, detoxin P2, detoxin P3	Amycolatopsis jejuensis

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000321.4	0.99	NRPS	chaetocin	Collariella virescens
BGC0001240.4	0.64	NRPS	serinocyclin A, serinocyclin B	Metarhizium robertsii
BGC0001641.4	0.61	NRPS	kolossin	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001585.3	0.53	other (other)	melinacidin IV	Escovopsis weberi
BGC0000292.4	0.52	NRPS	acetylaranotin	Aspergillus terreus NIH2624
BGC0002226.3	0.48	NRPS	acu-dioxomorpholine B, acu-dioxomorpholine A	Aspergillus aculeatus ATCC 16872
BGC0001609.4	0.45	NRPS	gliovirin	Trichoderma virens Gv29-8
BGC0000372.5	0.44	NRPS	hexadehydroastechrome, terezine-D, astechrome	Aspergillus fumigatus Af293
BGC0001841.2	0.42	NRPS, PKS	detoxin P1, detoxin P2, detoxin P3	Amycolatopsis jejuensis
BGC0001123.5	0.42	NRPS	aspirochlorine	Aspergillus oryzae RIB40

Similar known clusters from MIBiG 4.0

Module view

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Detailed domain annotation

Selected features only

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NRPS/PKS products

NRPS/PKS substrates

Predicted core structure(s)

For candidate cluster 1, location 9833 - 43979:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (Trp)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

ctg1_orf10: Trp

Search NORINE for peptide: strict or relaxed

AMP-binding (1050..1463): Trp

nrpys: Trp

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aromatic (Phe, Tyr, diOH-Bz, Ph-Gly, bOH-Tyr)
Large clusters prediction:: Aromatic side chain (Phe, Trp, Ph-Gly, Tyr, bOH-Tyr)
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DYVTYTAICK
Nearest Stachelhaus code(s):: Trp DYVTYTAICK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

Link to PARAS substrate predictor