BGC0000326 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0000326 (Streptomyces lavendulae)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	NRPS	1	55,972	isocomplestatin	NRPS:Type I	100%

BGC0000326 - Region 1 - NRPS

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Location: 1 - 55,972 nt. (total: 55,972 nt) Show pHMM detection rules used

Region on contig edge.

NRPS: cds(Condensation and (AMP-binding or A-OX))

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

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Gene details

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Gene overview

MIBiG

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 55,973
Label		BGC0000326

Detailed domain annotation

Selected features only

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Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000326	1.00	NRP	isocomplestatin	Streptomyces lavendulae
BGC0002637	0.43	NRP	rimomycin A, rimomycin B, rimomycin C	Streptomyces sp. WAC 06783
BGC0002341	0.35	Other	3,5-dibromo-p-anisic acid	Planctomycetales bacterium 10988
BGC0002608	0.33	NRP, Polyketide	ochratoxin A	Aspergillus steynii
BGC0001434	0.33	NRP	nematophin	Xenorhabdus budapestensis
BGC0002071	0.32	NRP	virginiafactin A, virginiafactin B, virginiafactin C, virginiafactin D	Pseudomonas sp. QS1027
BGC0002631	0.32	RiPP	myxarylin	Pyxidicoccus fallax
BGC0000351	0.31	NRP	exochelin	Mycolicibacterium smegmatis MC2 155
BGC0000343	0.31	NRP	enterobactin	Pseudomonas sp. J465
BGC0000900	0.30	Other	ferrichrome	Aspergillus oryzae

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000326	1.00	NRP	isocomplestatin	Streptomyces lavendulae
BGC0002637	0.74	NRP	rimomycin A, rimomycin B, rimomycin C	Streptomyces sp. WAC 06783
BGC0002341	0.68	Other	3,5-dibromo-p-anisic acid	Planctomycetales bacterium 10988
BGC0002608	0.66	NRP, Polyketide	ochratoxin A	Aspergillus steynii
BGC0001434	0.66	NRP	nematophin	Xenorhabdus budapestensis
BGC0002071	0.66	NRP	virginiafactin A, virginiafactin B, virginiafactin C, virginiafactin D	Pseudomonas sp. QS1027
BGC0002631	0.65	RiPP	myxarylin	Pyxidicoccus fallax
BGC0000351	0.65	NRP	exochelin	Mycolicibacterium smegmatis MC2 155
BGC0000343	0.65	NRP	enterobactin	Pseudomonas sp. J465
BGC0000900	0.64	Other	ferrichrome	Aspergillus oryzae

Similar known gene clusters from MIBiG 4.0

Module view

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NRPS/PKS products

NRPS/PKS substrates

Predicted core structure(s)

For candidate cluster 1, location 0 - 55972:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (X - D-Trp) + (D-Hpg) + (D-Hpg - D-Hpg - D-NMe-Tyr) + (Hpg)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

AAK81824.1

Search NORINE for peptide: strict or relaxed

AMP-binding (16..388): X

nrpys: dclohBfa, Hpg

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Aliphatic chain or phenyl group with -OH (Ser, Thr, Dhpg, Hpg)
Small clusters prediction:: Polar, uncharged (hydroxy-phenyl) (Dhpg, Hpg)
Single AA prediction:: hpg (Hpg)

Stachelhaus prediction details:

Stachelhaus sequence:: DIFHLGLLCK
Nearest Stachelhaus code(s):: dclohBfa or Hpg DIFHLGLLCK (100% 8Å match); Hpg DIFHLGLLCK (91% 8Å match)
Stachelhaus code match:: 100% (strong)

AMP-binding (1048..1438): Trp

nrpys: Trp

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Aromatic side chain (Phe, Trp, Ph-Gly, Tyr, bOH-Tyr)
Small clusters prediction:: Unpolar aromatic ring (Phe, Trp)
Single AA prediction:: trp (Trp)

Stachelhaus prediction details:

Stachelhaus sequence:: DVAVVGEVVK
Nearest Stachelhaus code(s):: Trp DVAVVGEVVK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

AAK81825.1

Search NORINE for peptide: strict or relaxed

AMP-binding (471..846): Hpg

nrpys: Hpg

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Aliphatic chain or phenyl group with -OH (Ser, Thr, Dhpg, Hpg)
Small clusters prediction:: Polar, uncharged (hydroxy-phenyl) (Dhpg, Hpg)
Single AA prediction:: hpg (Hpg)

Stachelhaus prediction details:

Stachelhaus sequence:: DIFHLGLLCK
Nearest Stachelhaus code(s):: Hpg DIFHLGLLCK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

AAK81826.1

Search NORINE for peptide: strict or relaxed

AMP-binding (462..855): Hpg

nrpys: Hpg

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Aliphatic chain or phenyl group with -OH (Ser, Thr, Dhpg, Hpg)
Small clusters prediction:: Polar, uncharged (hydroxy-phenyl) (Dhpg, Hpg)
Single AA prediction:: hpg (Hpg)

Stachelhaus prediction details:

Stachelhaus sequence:: DIFHLGLLCK
Nearest Stachelhaus code(s):: Hpg DIFHLGLLCK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

AMP-binding (1977..2350): Hpg

nrpys: Hpg

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Aliphatic chain or phenyl group with -OH (Ser, Thr, Dhpg, Hpg)
Small clusters prediction:: Polar, uncharged (hydroxy-phenyl) (Dhpg, Hpg)
Single AA prediction:: hpg (Hpg)

Stachelhaus prediction details:

Stachelhaus sequence:: DIFHLGLLCK
Nearest Stachelhaus code(s):: Hpg DIFHLGLLCK (100% 8Å match); dclohBfa or Hpg DIFHLGLLCK (91% 8Å match)
Stachelhaus code match:: 100% (strong)

AMP-binding (3483..3873): Tyr

nrpys: Tyr

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aromatic (Phe, Tyr, diOH-Bz, Ph-Gly, bOH-Tyr)
Large clusters prediction:: Aromatic side chain (Phe, Trp, Ph-Gly, Tyr, bOH-Tyr)
Small clusters prediction:: Polar aromatic ring (Tyr, bOH-Tyr)
Single AA prediction:: tyr (Tyr)

Stachelhaus prediction details:

Stachelhaus sequence:: DASTVAAVCK
Nearest Stachelhaus code(s):: Tyr DASTVAAVCK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

AAK81827.1

Search NORINE for peptide: strict or relaxed

AMP-binding (462..854): Hpg

nrpys: Hpg

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Aliphatic chain or phenyl group with -OH (Ser, Thr, Dhpg, Hpg)
Small clusters prediction:: Polar, uncharged (hydroxy-phenyl) (Dhpg, Hpg)
Single AA prediction:: hpg (Hpg)

Stachelhaus prediction details:

Stachelhaus sequence:: DAFHLGLLCK
Nearest Stachelhaus code(s):: Hpg DAFHLGLLCK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

AMP-binding (1515..1887): Tyr

nrpys: Tyr

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aromatic (Phe, Tyr, diOH-Bz, Ph-Gly, bOH-Tyr)
Large clusters prediction:: Aromatic side chain (Phe, Trp, Ph-Gly, Tyr, bOH-Tyr)
Small clusters prediction:: Polar aromatic ring (Tyr, bOH-Tyr)
Single AA prediction:: tyr (Tyr)

Stachelhaus prediction details:

Stachelhaus sequence:: AGGGID-VDK
Nearest Stachelhaus code(s):
Stachelhaus code match:: 0% (weak)