BGC0000326: isocomplestatin biosynthetic gene cluster from Streptomyces lavendulae
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Location: 1 - 55,972 nt. (total: 55,972 nt).
This entry is originally from NCBI GenBank AF386507.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
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Gene details
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General
Compounds
Genes
Biosynthesis
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0000326
Short description isocomplestatin biosynthetic gene cluster from Streptomyces lavendulae
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: unknown
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRPS (Type I)
Loci
AF386507.1
via
Compounds
  • isocomplestatin
Species Streptomyces lavendulae [taxonomy]
References
Chemical products information
isocomplestatin Evidence:
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C61H45Cl6N7O15
Chemical database entries
NPAtlas
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • AAK81822.1
 2020 - 3066 (+) transcriptional regulator
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    • AAK81823.1
    		 3491 - 5617 (+) ABC transporter
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      • AAK81824.1
      		 5664 - 12014 (+) peptide synthetase
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        • AAK81825.1
        		 12011 - 16606 (+) peptide synthetase
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          • AAK81826.1
          		 16705 - 31401 (+) peptide synthetase
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            • AAK81827.1
            		 31439 - 37933 (+) peptide synthetase
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              • AAK81828.1
              		 37938 - 38159 (+) hypothetical protein
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                • AAK81829.1
                		 38198 - 39475 (+) integral membrane ion antiporter
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                  • AAK81830.1
                  		 39504 - 40997 (+) non-heme halogenase
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                    • AAK81831.1
                    		 41015 - 42208 (+) P450-related oxidase
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                      • AAK81832.1
                      		 42222 - 43493 (+) P450-related oxidase
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                        • AAK81833.1
                        		 43538 - 43756 (+) ferredoxin
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                          • AAK81834.1
                          		 43834 - 44952 (-) glycolate oxidase
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                            • AAK81835.1
                            		 44939 - 45955 (-) hydroxyphenyl pyruvate dioxygenase
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                              • AAK81836.1
                              		 46193 - 47539 (+) aminotransferase
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                                • AAK81837.1
                                		 47536 - 48684 (+) prephenate dehydrogenase
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                                  Biosynthesis information

                                  Biosynthetic modules

                                  Name
                                  Unk01
                                  Type
                                  nrps-type1
                                  Genes
                                  AAK81824.1
                                  Substrates
                                  p-hydroxybenzoylformic acid (evidence: Structure-based inference [2])
                                  Integrated Monomers
                                  Domains
                                  adenylation
                                  Name
                                  Unk02
                                  Type
                                  nrps-type1
                                  Genes
                                  AAK81824.1
                                  Substrates
                                  tryptophan (evidence: Structure-based inference [2])
                                  Integrated Monomers
                                  Domains
                                  adenylation
                                  Name
                                  Unk03
                                  Type
                                  nrps-type1
                                  Genes
                                  AAK81825.1
                                  Substrates
                                  4-hydroxyphenylglycine (evidence: Structure-based inference [1], [2])
                                  Integrated Monomers
                                  Domains
                                  adenylation
                                  Name
                                  Unk04
                                  Type
                                  nrps-type1
                                  Genes
                                  AAK81826.1
                                  Substrates
                                  4-hydroxyphenylglycine (evidence: Structure-based inference [1], [2])
                                  Integrated Monomers
                                  Domains
                                  adenylation
                                  Name
                                  Unk05
                                  Type
                                  nrps-type1
                                  Genes
                                  AAK81826.1
                                  Substrates
                                  4-hydroxyphenylglycine (evidence: Structure-based inference [1], [2])
                                  Integrated Monomers
                                  Domains
                                  adenylation
                                  Name
                                  Unk06
                                  Type
                                  nrps-type1
                                  Genes
                                  AAK81826.1
                                  Substrates
                                  tyrosine (evidence: Structure-based inference [2])
                                  Integrated Monomers
                                  Domains
                                  adenylation
                                  Name
                                  Unk07
                                  Type
                                  nrps-type1
                                  Genes
                                  AAK81827.1
                                  Substrates
                                  4-hydroxyphenylglycine (evidence: Structure-based inference [1], [2])
                                  Integrated Monomers
                                  Domains
                                  adenylation
                                  Annotation changelog

                                  Entry version: 4

                                  Date
                                  Changes
                                  Submitters
                                  Reviewers
                                  2022-10-07
                                  Update chemical activity to schema version 2.11
                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                  Entry version: 3

                                  Date
                                  Changes
                                  Submitters
                                  Reviewers
                                  2022-09-15
                                  Updated bioactivity data
                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                  2022-09-15
                                  Added NRP substrate specificities
                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                  Entry version: 2

                                  Date
                                  Changes
                                  Submitters
                                  Reviewers
                                  2019-10-16
                                  Migrated from v1.4
                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                  2019-10-16
                                  Updated compound(s) information (NPAtlas curation)
                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                  Entry version: 1

                                  Date
                                  Changes
                                  Submitters
                                  Reviewers
                                  2015-06-12
                                  Submitted
                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
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