BGC0000327 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0000327 (Streptomyces ambofaciens ATCC 23877)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	NRPS	1	29,143	netropsin	NRPS:Type I	100%

BGC0000327 - Region 1 - NRPS

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Location: 1 - 29,143 nt. (total: 29,143 nt) Show pHMM detection rules used

Region on contig edge.

NRPS: cds(Condensation and (AMP-binding or A-OX))

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

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Gene details

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Gene overview

MIBiG

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 29,144
Label		BGC0000327

Detailed domain annotation

Selected features only

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Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000327	0.91	NRP	netropsin	Streptomyces ambofaciens ATCC 23877
BGC0002042	0.44	NRP	anthelvencin A, anthelvencin B, anthelvencin C	Streptomyces venezuelae
BGC0000900	0.31	Other	ferrichrome	Aspergillus oryzae
BGC0000375	0.30	NRP	indigoidine	Streptomyces chromofuscus
BGC0000772	0.29	Saccharide	lipopolysaccharide	Brucella melitensis
BGC0000707	0.29	Saccharide	kasugamycin	Streptomyces kasugaensis
BGC0000348	0.29	NRP	ergovaline	Epichloe festucae var. lolii
BGC0000343	0.28	NRP	enterobactin	Pseudomonas sp. J465
BGC0000876	0.28	Other	neopolyoxin C	Streptomyces tendae
BGC0001817	0.28	Other	vancosamine	Streptomyces sp. WAC2288

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000327	1.00	NRP	netropsin	Streptomyces ambofaciens ATCC 23877
BGC0002042	0.78	NRP	anthelvencin A, anthelvencin B, anthelvencin C	Streptomyces venezuelae
BGC0000375	0.67	NRP	indigoidine	Streptomyces chromofuscus
BGC0000772	0.66	Saccharide	lipopolysaccharide	Brucella melitensis
BGC0000343	0.66	NRP	enterobactin	Pseudomonas sp. J465
BGC0000900	0.64	Other	ferrichrome	Aspergillus oryzae
BGC0001147	0.64	NRP	disgocidine, distamycin, congocidine	Streptomyces netropsis
BGC0002652	0.63	Other, Saccharide	cytosaminomycin F, cytosaminomycin G, streptcytosine P, plicacetin, 40551-F, 12F-plicacetin, streptcytosine D, streptcytosine E	Streptomyces sp. SHP22-7
BGC0000707	0.63	Saccharide	kasugamycin	Streptomyces kasugaensis
BGC0000348	0.62	NRP	ergovaline	Epichloe festucae var. lolii

Similar known gene clusters from MIBiG 4.0

Module view

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NRPS/PKS products

NRPS/PKS substrates

Predicted core structure(s)

For candidate cluster 1, location 0 - 23627:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (X)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

SAMR0901

AMP-binding (25..432): X

nrpys: Gua

SVM prediction details:

Predicted physicochemical class:: hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
Large clusters prediction:: Aliphatic chain with H-bond donor (Asp, Asn, Glu, Gln, Aad)
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: SVEQVGEVSK
Nearest Stachelhaus code(s):: Gua SVEQVGEVSK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

SAMR0921

AMP-binding (21..433): X

nrpys: Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: N/A
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: -GAVLSVVIK
Nearest Stachelhaus code(s):
Stachelhaus code match:: 0% (weak)