BGC0000333: cyclomarin D biosynthetic gene cluster from Salinispora arenicola CNS-205
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Location: 5,140,169 - 5,187,645 nt. (total: 47,477 nt).
This entry is originally from NCBI GenBank CP000850.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
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Gene details
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General
Compounds
Genes
Biosynthesis
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0000333
Short description cyclomarin D biosynthetic gene cluster from Salinispora arenicola CNS-205
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: complete
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRPS (Type I)
Loci
CP000850.1
5140169 - 5187645
via Knock-out studies
Compounds
  • cyclomarin D
Species Salinispora arenicola CNS-205 [taxonomy]
References
Chemical products information
cyclomarin D Evidence:
Copy SMILES
C55H80N8O10
Chemical database entries
NPAtlas
PubCHEM
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • Sare_4547
  • ABW00316.1
 5140169 - 5141329 (-) pyruvate phosphate dikinase PEP/pyruvate-binding
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    • Sare_4548
    • ABW00317.1
    		 5141420 - 5142064 (+) conserved hypothetical protein
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      • Sare_4549
      • ABW00318.1
      		 5142074 - 5142676 (+) Phosphoglycerate mutase
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        • Sare_4550
        • ABW00319.1
        		 5142742 - 5143686 (+) daunorubicin resistance ABC transporter ATPase subunit
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          • Sare_4551
          • ABW00320.1
          		 5143683 - 5144477 (+) ABC-2 type transporter
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            • Sare_4552
            • ABW00321.1
            		 5144395 - 5147526 (-) transcriptional regulator, winged helix family
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              • Sare_4553
              • ABW00322.1
              		 5147696 - 5148910 (+) cytochrome P450
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                • Sare_4554
                • ABW00323.1
                		 5148907 - 5149698 (+) methyltransferase FkbM family
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                  • Sare_4555
                  • ABW00324.1
                  		 5149695 - 5150423 (+) Thioesterase
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                    • Sare_4556
                    • ABW00325.1
                    		 5150433 - 5150924 (+) hypothetical protein
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                      • Sare_4557
                      • ABW00326.1
                      		 5150951 - 5152213 (-) cytochrome P450
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                        • Sare_4558
                        • ABW00327.1
                        		 5152562 - 5153386 (+) transposase IS4 family protein
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                          • Sare_4559
                          • ABW00328.1
                          		 5153724 - 5156357 (+) transcriptional regulator, LuxR family
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                            • Sare_4560
                            • ABW00329.1
                            		 5156489 - 5157676 (+) cytochrome P450
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                              • Sare_4561
                              • ABW00330.1
                              		 5157756 - 5158550 (+) Phytanoyl-CoA dioxygenase
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                                • Sare_4562
                                • ABW00331.1
                                		 5158591 - 5181948 (+) amino acid adenylation domain
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                                  • Sare_4563
                                  • ABW00332.1
                                  		 5181948 - 5182163 (+) MbtH domain protein
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                                    • Sare_4564
                                    • ABW00333.1
                                    		 5182167 - 5182757 (+) isopentenyl-diphosphate delta-isomerase, type 1
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                                      • Sare_4565
                                      • ABW00334.1
                                      		 5182801 - 5183922 (+) hypothetical protein
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                                        • Sare_4566
                                        • ABW00335.1
                                        		 5183919 - 5184806 (+) Acetaldehyde dehydrogenase
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                                          • Sare_4567
                                          • ABW00336.1
                                          		 5184806 - 5185852 (+) pyruvate carboxyltransferase
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                                            • Sare_4568
                                            • ABW00337.1
                                            		 5185871 - 5186854 (+) Methyltransferase type 12
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                                              • Sare_4569
                                              • ABW00338.1
                                              		 5186851 - 5187645 (+) 4-oxalocrotonate decarboxylase
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                                                Biosynthesis information

                                                Biosynthetic modules

                                                Name
                                                7
                                                Type
                                                nrps-type1
                                                Genes
                                                Sare_4562
                                                Substrates
                                                2-amino-3,5-dimethyl-4-hexenoic Acid (evidence: Structure-based inference)
                                                Integrated Monomers
                                                Domains
                                                condensation (LCL), adenylation
                                                Name
                                                6
                                                Type
                                                nrps-type1
                                                Genes
                                                Sare_4562
                                                Substrates
                                                leucine (evidence: Structure-based inference)
                                                Integrated Monomers
                                                Domains
                                                condensation (LCL), adenylation
                                                Name
                                                5
                                                Type
                                                nrps-type1
                                                Genes
                                                Sare_4562
                                                Substrates
                                                valine (evidence: Structure-based inference)
                                                Integrated Monomers
                                                Domains
                                                condensation (LCL), adenylation
                                                Name
                                                4
                                                Type
                                                nrps-type1
                                                Genes
                                                Sare_4562
                                                Substrates
                                                phenylalanine (evidence: Structure-based inference)
                                                Integrated Monomers
                                                Domains
                                                condensation (LCL), adenylation
                                                Name
                                                3
                                                Type
                                                nrps-type1
                                                Genes
                                                Sare_4562
                                                Substrates
                                                alanine (evidence: Structure-based inference)
                                                Integrated Monomers
                                                Domains
                                                condensation (LCL), adenylation
                                                Name
                                                2
                                                Type
                                                nrps-type1
                                                Genes
                                                Sare_4562
                                                Substrates
                                                leucine (evidence: Structure-based inference)
                                                Integrated Monomers
                                                Domains
                                                condensation (LCL), adenylation, methyltransferase
                                                Name
                                                1
                                                Type
                                                nrps-type1
                                                Genes
                                                Sare_4562
                                                Substrates
                                                tryptophan, 1-(1,1-dimethylallyl)-tryptophan, N-(1-methyl)-tryptophan, N-(1-propargyl)-tryptophan (evidence: Feeding study, Knock-out studies, Structure-based inference)
                                                Integrated Monomers
                                                Domains
                                                adenylation
                                                Annotation changelog

                                                Entry version: 4

                                                Date
                                                Changes
                                                Submitters
                                                Reviewers
                                                2022-10-07
                                                Update chemical activity to schema version 2.11
                                                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                Entry version: 3

                                                Date
                                                Changes
                                                Submitters
                                                Reviewers
                                                2022-09-15
                                                Corrected NRP module activity
                                                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                2022-09-15
                                                Corrected gene identifiers
                                                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                2022-09-15
                                                Corrected NRP gene names
                                                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                2022-09-15
                                                Updated NRP substrate specificities
                                                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                Entry version: 2

                                                Date
                                                Changes
                                                Submitters
                                                Reviewers
                                                2019-10-16
                                                Migrated from v1.4
                                                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                2019-10-16
                                                Updated compound(s) information (NPAtlas curation)
                                                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                Entry version: 1

                                                Date
                                                Changes
                                                Submitters
                                                Reviewers
                                                2015-06-12
                                                Submitted
                                                • (ID: FGOE6VD55GZRETNYSNOKUJZO)
                                                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                Detailed domain annotation
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