BGC0000334: cyclosporin biosynthetic gene cluster from Tolypocladium inflatum NRRL 8044
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Location: 1,270,402 - 1,378,084 nt. (total: 107,683 nt).
This entry is originally from NCBI GenBank QEPI01000018.1, but has been modified (see Modifications tab for details).

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
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Gene details
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General
Compounds
Genes
NRP
History
NRPS/PKS domains
KnownClusterBlast
Modifications
General information about the BGC
MIBiG accession BGC0000334
Short description cyclosporin biosynthetic gene cluster from Tolypocladium inflatum NRRL 8044
Status Minimal annotation: no
A minimal annotation only contains information on the BGC loci and one or more linked chemical product(s)

Completeness: Unknown
Whether the loci encodes everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRP
Loci NCBI GenBank: QEPI01000018.1
Compounds
  • cyclosporin
Species Tolypocladium inflatum NRRL 8044 [taxonomy]
References
Chemical products information
cyclosporin
Copy SMILES
C62H111N11O12
Chemical database entries
PubCHEM
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • cds_0_1525
 1270403 - 1271927 (+)
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  • cds_2368_3434
 1272771 - 1273836 (+)
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  • cds_3806_6518
 1274209 - 1276920 (-)
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  • cds_7545_9017
 1277948 - 1279419 (+)
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  • cds_9169_10992
 1279572 - 1281394 (-)
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  • cds_11355_12157
 1281758 - 1282559 (+)
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  • cds_12312_14460
 1282715 - 1284862 (-)
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  • cds_16753_18238
 1287156 - 1288640 (+)
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  • simA
 1289514 - 1335359 (-)
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  • simB
 1336218 - 1338014 (+)
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  • simC
 1340760 - 1341592 (+)
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  • simD
 1342450 - 1346420 (-)
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  • simE
 1347534 - 1348864 (+)
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  • simF
 1348989 - 1350603 (-)
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  • simG
 1351282 - 1360001 (-)
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  • simH
 1361610 - 1362714 (+)
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  • simI
 1364850 - 1366103 (+)
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  • simJ
 1367154 - 1368405 (-)
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  • simK
 1369665 - 1371787 (-)
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  • simL
 1376526 - 1378084 (+)
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NRP-specific information
Subclass N/A
Cyclic? no
NRP-synthases
Gene Modules
simA
Module ?
Specificity: D-alanine
Evidence for specificity:
Module ?
Specificity: leucine
Evidence for specificity:
Module ?
Specificity: leucine
Evidence for specificity:
Module ?
Specificity: valine
Evidence for specificity:
Module ?
Specificity: 4R-butenyl-4R-methylthreonine
Evidence for specificity:
Module ?
Specificity: 2-aminobutyric acid
Evidence for specificity:
Module ?
Specificity: glycine
Evidence for specificity:
Module ?
Specificity: leucine
Evidence for specificity:
Module ?
Specificity: valine
Evidence for specificity:
Module ?
Specificity: leucine
Evidence for specificity:
Module ?
Specificity: alanine
Evidence for specificity:
Annotation changelog
MIBiG version Submitter Notes
1.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Submitted
2.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Migrated from v1.4
  • Updated compound(s) information (NPAtlas curation)
3.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Corrected gene annotations, along with a new sequence
  • Corrected compound name
  • Added NRP substrate specificities
Detailed domain annotation
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Similar known gene clusters
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Modifications to original record
  • cds_0_1525 was added
  • cds_2368_3434 was added
  • cds_3806_6518 was added
  • cds_7545_9017 was added
  • cds_9169_10992 was added
  • cds_11355_12157 was added
  • cds_12312_14460 was added
  • cds_16753_18238 was added
  • simA was added
  • simB was added
  • simC was added
  • simD was added
  • simE was added
  • simF was added
  • simG was added
  • simH was added
  • simI was added
  • simJ was added
  • simK was added
  • simL was added