BGC0000334: cyclosporin A biosynthetic gene cluster from Tolypocladium inflatum NRRL 8044
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Location: 1,270,402 - 1,378,084 nt. (total: 107,683 nt).
This entry is originally from NCBI GenBank QEPI01000018.1, but has been modified (see Modifications tab for details).

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
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General
Compounds
Genes
Biosynthesis
History
NRPS/PKS domains
KnownClusterBlast
Modifications
General information about the BGC
MIBiG accession BGC0000334
Short description cyclosporin A biosynthetic gene cluster from Tolypocladium inflatum NRRL 8044
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: unknown
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRPS (Type I)
Loci
QEPI01000018.1
1270402 - 1378084
via
Compounds
  • cyclosporin A
Species Tolypocladium inflatum NRRL 8044 [taxonomy]
References
Chemical products information
cyclosporin A [synonyms: cyclosporine, cyclosporin] Evidence: Mass spectrometry [1]
Copy SMILES
C62H111N11O12
Chemical database entries
PubCHEM
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • cds_0_1525
 1270403 - 1271927 (+)
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    • cds_2368_3434
    		 1272771 - 1273836 (+)
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      • cds_3806_6518
      		 1274209 - 1276920 (-)
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        • cds_7545_9017
        		 1277948 - 1279419 (+)
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          • cds_9169_10992
          		 1279572 - 1281394 (-)
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            • cds_11355_12157
            		 1281758 - 1282559 (+)
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              • cds_12312_14460
              		 1282715 - 1284862 (-)
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                • cds_16753_18238
                		 1287156 - 1288640 (+)
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                  • simA
                  		 1289514 - 1335359 (-)
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                    • simB
                    		 1336218 - 1338014 (+)
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                      • simC
                      		 1340760 - 1341592 (+)
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                        • simD
                        		 1342450 - 1346420 (-)
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                          • simE
                          		 1347534 - 1348864 (+)
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                            • simF
                            		 1348989 - 1350603 (-)
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                              • simG
                              		 1351282 - 1360001 (-)
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                                • simH
                                		 1361610 - 1362714 (+)
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                                  • simI
                                  		 1364850 - 1366103 (+)
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                                    • simJ
                                    		 1367154 - 1368405 (-)
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                                      • simK
                                      		 1369665 - 1371787 (-)
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                                        • simL
                                        		 1376526 - 1378084 (+)
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                                          Biosynthesis information

                                          Biosynthetic modules

                                          Name
                                          Unk01
                                          Type
                                          nrps-type1
                                          Genes
                                          simA
                                          Substrates
                                          D-alanine (evidence: )
                                          Integrated Monomers
                                          Domains
                                          adenylation
                                          Name
                                          Unk02
                                          Type
                                          nrps-type1
                                          Genes
                                          simA
                                          Substrates
                                          leucine (evidence: )
                                          Integrated Monomers
                                          Domains
                                          adenylation
                                          Name
                                          Unk03
                                          Type
                                          nrps-type1
                                          Genes
                                          simA
                                          Substrates
                                          leucine (evidence: )
                                          Integrated Monomers
                                          Domains
                                          adenylation
                                          Name
                                          Unk04
                                          Type
                                          nrps-type1
                                          Genes
                                          simA
                                          Substrates
                                          valine (evidence: )
                                          Integrated Monomers
                                          Domains
                                          adenylation
                                          Name
                                          Unk05
                                          Type
                                          nrps-type1
                                          Genes
                                          simA
                                          Substrates
                                          4R-butenyl-4R-methylthreonine (evidence: )
                                          Integrated Monomers
                                          Domains
                                          adenylation
                                          Name
                                          Unk06
                                          Type
                                          nrps-type1
                                          Genes
                                          simA
                                          Substrates
                                          2-aminobutyric acid (evidence: )
                                          Integrated Monomers
                                          Domains
                                          adenylation
                                          Name
                                          Unk07
                                          Type
                                          nrps-type1
                                          Genes
                                          simA
                                          Substrates
                                          glycine (evidence: )
                                          Integrated Monomers
                                          Domains
                                          adenylation
                                          Name
                                          Unk08
                                          Type
                                          nrps-type1
                                          Genes
                                          simA
                                          Substrates
                                          leucine (evidence: )
                                          Integrated Monomers
                                          Domains
                                          adenylation
                                          Name
                                          Unk09
                                          Type
                                          nrps-type1
                                          Genes
                                          simA
                                          Substrates
                                          valine (evidence: )
                                          Integrated Monomers
                                          Domains
                                          adenylation
                                          Name
                                          Unk10
                                          Type
                                          nrps-type1
                                          Genes
                                          simA
                                          Substrates
                                          leucine (evidence: )
                                          Integrated Monomers
                                          Domains
                                          adenylation
                                          Name
                                          Unk11
                                          Type
                                          nrps-type1
                                          Genes
                                          simA
                                          Substrates
                                          alanine (evidence: )
                                          Integrated Monomers
                                          Domains
                                          adenylation
                                          Annotation changelog

                                          Entry version: next

                                          Date
                                          Changes
                                          Submitters
                                          Reviewers
                                          2024-07-24
                                          MIBiG v4 annotathon
                                          • (ID: W2BYPPSEDLNNXA67JK6WMVNI)
                                          • (ID: C62OJVVH7XOTOTFZSJT727YU)
                                          • (ID: X3QVFXOIMTNXSB4JQGP4RI6A)
                                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                          Entry version: 3

                                          Date
                                          Changes
                                          Submitters
                                          Reviewers
                                          2022-09-15
                                          Corrected gene annotations, along with a new sequence
                                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                          2022-09-15
                                          Corrected compound name
                                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                          2022-09-15
                                          Added NRP substrate specificities
                                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                          Entry version: 2

                                          Date
                                          Changes
                                          Submitters
                                          Reviewers
                                          2019-10-16
                                          Migrated from v1.4
                                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                          2019-10-16
                                          Updated compound(s) information (NPAtlas curation)
                                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                          Entry version: 1

                                          Date
                                          Changes
                                          Submitters
                                          Reviewers
                                          2015-06-12
                                          Submitted
                                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                          Detailed domain annotation
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                                          Modifications to original record
                                          • cds_0_1525 was added
                                          • cds_2368_3434 was added
                                          • cds_3806_6518 was added
                                          • cds_7545_9017 was added
                                          • cds_9169_10992 was added
                                          • cds_11355_12157 was added
                                          • cds_12312_14460 was added
                                          • cds_16753_18238 was added
                                          • simA was added
                                          • simB was added
                                          • simC was added
                                          • simD was added
                                          • simE was added
                                          • simF was added
                                          • simG was added
                                          • simH was added
                                          • simI was added
                                          • simJ was added
                                          • simK was added
                                          • simL was added