BGC0000337 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0000337 (Metarhizium robertsii ARSEF 23)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	NRPS	1	106,198	destruxin A	NRPS:Type I	100%

BGC0000337 - Region 1 - NRPS

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Location: 1 - 106,198 nt. (total: 106,198 nt) Show pHMM detection rules used

Region on contig edge.

NRPS: cds(Condensation and (AMP-binding or A-OX))

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

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Gene details

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Gene overview

MIBiG

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 106,199
Label		BGC0000337

Detailed domain annotation

Selected features only

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Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000337	1.04	NRP	destruxin A	Metarhizium robertsii ARSEF 23
BGC0001893	0.60	Other	abscisic acid	Botrytis cinerea B05.10
BGC0001518	0.54	Terpene	astellolide A	Aspergillus oryzae RIB40
BGC0000321	0.54	NRP	chaetocin	Collariella virescens
BGC0001135	0.51	NRP	bicornutin A1, bicornutin A2	Xenorhabdus budapestensis
BGC0002135	0.51	NRP	bovienimide A	Xenorhabdus bovienii SS-2004
BGC0001585	0.50	Alkaloid	melinacidin IV	Escovopsis weberi
BGC0002248	0.46	Terpene, NRP	flavunoidine	Aspergillus flavus NRRL3357
BGC0000686	0.45	Terpene	helvolic acid	Aspergillus fumigatus Af293
BGC0001277	0.45	Terpene	nivalenol, vomitoxin, 3-acetyldeoxynivalenol, 15-acetyldeoxynivalenol, neosolaniol, calonectrin, apotrichodiol, isotrichotriol, 15-deacetylcalonectrin, T-2 toxin, 3-acetyl T-2 toxin, trichodiene	Fusarium graminearum

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000337	1.00	NRP	destruxin A	Metarhizium robertsii ARSEF 23
BGC0000313	0.68	NRP	beauvericin	Beauveria bassiana
BGC0000342	0.68	NRP	enniatin	Fusarium equiseti
BGC0002670	0.67	Other	fosfonochlorin	Fusarium oxysporum f. sp. lycopersici 4287
BGC0000355	0.67	NRP	fumiquinazoline A, fumiquinazoline C, fumiquinazoline D	Aspergillus fumigatus Af293
BGC0002710	0.67	NRP	metachelin C, metachelin A, metachelin A-CE, metachelin B, dimerumic acid 11-mannoside, dimerumic acid	Metarhizium robertsii ARSEF 23
BGC0002208	0.66	NRP	oxepinamide F	Aspergillus ustus
BGC0001659	0.66	Terpene	mangicol A	Fusarium equiseti
BGC0002245	0.66	Terpene	terpestacin, preterpestacin 3, preterpestacin 2, preterpestacin 1	Bipolaris maydis C5
BGC0001261	0.66	NRP	AM-toxin	Alternaria alternata

Similar known gene clusters from MIBiG 4.0

Module view

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NRPS/PKS products

NRPS/PKS substrates

Predicted core structure(s)

For candidate cluster 1, location 0 - 91714:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (X - Leu) + (bAla - D-X - Pro - Ile - NMe-Val - NMe-Ala)

Direct lookup in NORINE database: strict or relaxed

For candidate cluster 2, location 0 - 46899:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (X - Leu)

Direct lookup in NORINE database: strict or relaxed

For candidate cluster 3, location 27922 - 91714:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (bAla - D-X - Pro - Ile - NMe-Val - NMe-Ala)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

MAA_10036

Search NORINE for peptide: strict or relaxed

AMP-binding (14..409): X

nrpys: Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: N/A
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DAAVIGAIMK
Nearest Stachelhaus code(s):: Leu DAWIIGAIVK (41% 8Å match)
Stachelhaus code match:: 70% (weak)

AMP-binding (1109..1436): Leu

nrpys: Leu

SVM prediction details:

Predicted physicochemical class:: N/A
Large clusters prediction:: N/A
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DILILGGVAK
Nearest Stachelhaus code(s):: Leu DIFALGGVAK (47% 8Å match)
Stachelhaus code match:: 80% (moderate)

MAA_10043

Search NORINE for peptide: strict or relaxed

AMP-binding (262..662): bAla

nrpys: bAla

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
Small clusters prediction:: N/A
Single AA prediction:: ala (Ala)

Stachelhaus prediction details:

Stachelhaus sequence:: DIFYAIATAK
Nearest Stachelhaus code(s):: bAla DIFYAIATAK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

AMP-binding (1331..1740): X

nrpys: Hpea, dohPen

SVM prediction details:

Predicted physicochemical class:: N/A
Large clusters prediction:: N/A
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: GANLIGATVK
Nearest Stachelhaus code(s):: Hpea or dohPen GANLIGATVK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

AMP-binding (2862..3255): Pro

nrpys: Pro

SVM prediction details:

Predicted physicochemical class:: N/A
Large clusters prediction:: N/A
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DLHEIGIISK
Nearest Stachelhaus code(s):: Pro DLHEIGIISK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

AMP-binding (3923..4321): Ile

nrpys: Ile

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: N/A
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DGLFIGIPVK
Nearest Stachelhaus code(s):: Ile DGLFIGIPVK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

AMP-binding (4990..5390): Val

nrpys: Val

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
Small clusters prediction:: Aliphatic, branched hydrophobic (Val, Leu, Ile, Abu, Ival)
Single AA prediction:: val (Val)

Stachelhaus prediction details:

Stachelhaus sequence:: DAWFYGGTFK
Nearest Stachelhaus code(s):: Val DAWFYGGTFK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

AMP-binding (6465..6860): Ala

nrpys: Ala

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DVWIYAAVIK
Nearest Stachelhaus code(s):: Ala DVWIYAAVIK (100% 8Å match)
Stachelhaus code match:: 100% (strong)