Genomic loci for this biosynthetic pathway

Cluster Type From To
The following clusters are from record BGC0000337.1:
Cluster 1NRP1106198

BGC0000337, destruxins biosynthetic gene cluster from Metarhizium anisopliae. Locus 1. Full MIBiG entry.

Chemical compounds

Compound: destruxin
PubChem ID: 122810
SMILES string: Copy to clipboard
Molecular formula: C29H47N5O7
Average molecular mass: 577.723 Da
Molecular activity: Other

Class-specific details

Biosynthetic class(es):
Other (linear)
Thioesterase type:
Release / cyclization type:

Gene cluster description

destruxins (BGC0000337). Gene Cluster 1. Biosynthetic class = NRP. GenBank Not derived from GenBank. Click on genes for more information.


biosynthetic genes
transport-related genes
regulatory genes
other genes

Domain annotation

Homologous known gene clusters

General MIBiG information on this cluster

Complete gene cluster sequence?complete
Evidence for cluster-compound connection:Knock-out studies
Comments:The metabolite destruxins are used by the fungus to evade insect host immunities
Contact for this cluster:Chengshu Wang (Insitute of Plant Physiology and Ecology, Shanghai Institutes for Biological Sciences, CAS)

Literature references

1. Wang B et al. (2012) Unveiling the biosynthetic puzzle of destruxins in Metarhizium species. Proc Natl Acad Sci U S A 109(4):1287-92. doi:
2. Dunn VK, Sacco WP. (1988) Effect of instructional set on responses to the Geriatric Depression Scale. Psychol Aging 3(3):315-6.