BGC0000339: echinomycin biosynthetic gene cluster from Streptomyces lasaliensis
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Location: 1 - 45,600 nt. (total: 45,600 nt).
This entry is originally from NCBI GenBank AB211309.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
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Gene details
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General
Compounds
Genes
Biosynthesis
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0000339
Short description echinomycin biosynthetic gene cluster from Streptomyces lasaliensis
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: unknown
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRPS (Type I)
Loci
AB211309.1
via
Compounds
  • echinomycin
Species Streptomyces lasaliensis [taxonomy]
References
Chemical products information
echinomycin Evidence:
Copy SMILES
C51H64N12O12S2
Chemical database entries
PubCHEM
PubCHEM
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • BAE98151.1
  • ecm1
 4597 - 6180 (-) putative AMP-binding ligase
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    • BAE98152.1
    • ecm2
    		 6525 - 7271 (+) putative thioesterase
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      • BAE98153.1
      • ecm3
      		 7225 - 8313 (+) putative dehydrogenase
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        • BAE98154.1
        • ecm4
        		 8381 - 9799 (+) putative FAD-dependent oxidoreductase
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          • ecm5
          		 10146 - 10942 (-) putative transposase
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            • BAE98155.1
            • ecm6
            		 11240 - 19069 (+) putative non-ribosomal peptide synthetase
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              • BAE98156.1
              • ecm7
              		 19078 - 28485 (+) putative non-ribosomal peptide synthetase
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                • BAE98157.1
                • ecm8
                		 28532 - 28744 (+) MbtH like protein
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                  • BAE98158.1
                  • ecm9
                  		 28861 - 29364 (+) putative DNA-binding response regulator
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                    • BAE98159.1
                    • ecm10
                    		 29481 - 30239 (+) putative tetR family transcriptional regulatory protein
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                      • BAE98160.1
                      • ecm11
                      		 30252 - 30914 (-) putative tryptophan 2,3-dioxygenase
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                        • BAE98161.1
                        • ecm12
                        		 31136 - 32323 (+) putative cytochrome P450
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                          • BAE98162.1
                          • ecm13
                          		 32331 - 34127 (-) putative non-ribosomal peptide synthetase
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                            • BAE98163.1
                            • ecm14
                            		 34217 - 35425 (-) putative esterase
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                              • BAE98164.1
                              • ecm15
                              		 35494 - 36351 (-) putative transcriptional regulator
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                                • BAE98165.1
                                • ecm16
                                		 36429 - 38807 (+) UvrA-like protein
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                                  • BAE98166.1
                                  • ecm17
                                  		 39169 - 40110 (+) putative oxidoreductase
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                                    • BAE98167.1
                                    • ecm18
                                    		 40330 - 41004 (+) putative SAM-dependent methyltransferase
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                                      Biosynthesis information

                                      Biosynthetic modules

                                      Name
                                      Unk01
                                      Type
                                      nrps-type1
                                      Genes
                                      ecm1
                                      Substrates
                                      quinoxaline-2-carboxylic acid (evidence: Structure-based inference)
                                      Integrated Monomers
                                      Domains
                                      adenylation
                                      Name
                                      Unk02
                                      Type
                                      nrps-type1
                                      Genes
                                      ecm6
                                      Substrates
                                      serine (evidence: Structure-based inference, Sequence-based prediction)
                                      Integrated Monomers
                                      Domains
                                      adenylation
                                      Name
                                      Unk03
                                      Type
                                      nrps-type1
                                      Genes
                                      ecm6
                                      Substrates
                                      alanine (evidence: Structure-based inference, Sequence-based prediction)
                                      Integrated Monomers
                                      Domains
                                      adenylation
                                      Name
                                      Unk04
                                      Type
                                      nrps-type1
                                      Genes
                                      ecm7
                                      Substrates
                                      cysteine (evidence: Structure-based inference, Sequence-based prediction)
                                      Integrated Monomers
                                      Domains
                                      adenylation
                                      Name
                                      Unk05
                                      Type
                                      nrps-type1
                                      Genes
                                      ecm7
                                      Substrates
                                      valine (evidence: Structure-based inference, Sequence-based prediction)
                                      Integrated Monomers
                                      Domains
                                      adenylation
                                      Name
                                      Unk06
                                      Type
                                      nrps-type1
                                      Genes
                                      ecm13
                                      Substrates
                                      tryptophan (evidence: Structure-based inference, Sequence-based prediction)
                                      Integrated Monomers
                                      Domains
                                      adenylation
                                      Annotation changelog

                                      Entry version: 4

                                      Date
                                      Changes
                                      Submitters
                                      Reviewers
                                      2022-10-07
                                      Update chemical activity to schema version 2.11
                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                      Entry version: 3

                                      Date
                                      Changes
                                      Submitters
                                      Reviewers
                                      2022-09-15
                                      Updated bioactivity data
                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                      2022-09-15
                                      Added NRP substrate specificities
                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                      Entry version: 2

                                      Date
                                      Changes
                                      Submitters
                                      Reviewers
                                      2019-10-16
                                      Migrated from v1.4
                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                      2019-10-16
                                      Updated compound(s) information (NPAtlas curation)
                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                      Entry version: 1

                                      Date
                                      Changes
                                      Submitters
                                      Reviewers
                                      2015-06-12
                                      Submitted
                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                      Detailed domain annotation
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