BGC0000339: echinomycin biosynthetic gene cluster from Streptomyces lasaliensis
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Location: 1 - 45,600 nt. (total: 45,600 nt).
This entry is originally from NCBI GenBank AB211309.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
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Gene details
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General
Compounds
Genes
NRP
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0000339
Short description echinomycin biosynthetic gene cluster from Streptomyces lasaliensis
Status Minimal annotation: no
A minimal annotation only contains information on the BGC loci and one or more linked chemical product(s)

Completeness: Unknown
Whether the loci encodes everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRP
Loci NCBI GenBank: AB211309.1
Compounds
  • echinomycin
Species Streptomyces lasaliensis [taxonomy]
References
Chemical products information
echinomycin
Copy SMILES
C51H64N12O12S2
Chemical database entries
PubCHEM
PubCHEM
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • BAE98151.1
  • ecm1
 4597 - 6180 (-) putative AMP-binding ligase
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  • BAE98152.1
  • ecm2
 6525 - 7271 (+) putative thioesterase
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  • BAE98153.1
  • ecm3
 7225 - 8313 (+) putative dehydrogenase
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  • BAE98154.1
  • ecm4
 8381 - 9799 (+) putative FAD-dependent oxidoreductase
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  • ecm5
 10146 - 10942 (-) putative transposase
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  • BAE98155.1
  • ecm6
 11240 - 19069 (+) putative non-ribosomal peptide synthetase
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  • BAE98156.1
  • ecm7
 19078 - 28485 (+) putative non-ribosomal peptide synthetase
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  • BAE98157.1
  • ecm8
 28532 - 28744 (+) MbtH like protein
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  • BAE98158.1
  • ecm9
 28861 - 29364 (+) putative DNA-binding response regulator
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  • BAE98159.1
  • ecm10
 29481 - 30239 (+) putative tetR family transcriptional regulatory protein
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  • BAE98160.1
  • ecm11
 30252 - 30914 (-) putative tryptophan 2,3-dioxygenase
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  • BAE98161.1
  • ecm12
 31136 - 32323 (+) putative cytochrome P450
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  • BAE98162.1
  • ecm13
 32331 - 34127 (-) putative non-ribosomal peptide synthetase
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  • BAE98163.1
  • ecm14
 34217 - 35425 (-) putative esterase
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  • BAE98164.1
  • ecm15
 35494 - 36351 (-) putative transcriptional regulator
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  • BAE98165.1
  • ecm16
 36429 - 38807 (+) UvrA-like protein
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  • BAE98166.1
  • ecm17
 39169 - 40110 (+) putative oxidoreductase
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  • BAE98167.1
  • ecm18
 40330 - 41004 (+) putative SAM-dependent methyltransferase
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NRP-specific information
Subclass N/A
Cyclic? no
NRP-synthases
Gene Modules
ecm1
Module ?
Specificity: quinoxaline-2-carboxylic acid
Evidence for specificity:
  • Structure-based inference
ecm6
Module ?
Specificity: serine
Evidence for specificity:
  • Structure-based inference
  • Sequence-based prediction
Module ?
Specificity: alanine
Evidence for specificity:
  • Structure-based inference
  • Sequence-based prediction
ecm7
Module ?
Specificity: cysteine
Evidence for specificity:
  • Structure-based inference
  • Sequence-based prediction
Module ?
Specificity: valine
Evidence for specificity:
  • Structure-based inference
  • Sequence-based prediction
ecm13
Module ?
Specificity: tryptophan
Evidence for specificity:
  • Structure-based inference
  • Sequence-based prediction
Annotation changelog
MIBiG version Submitter Notes
1.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Submitted
2.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Migrated from v1.4
  • Updated compound(s) information (NPAtlas curation)
3.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Updated bioactivity data
  • Added NRP substrate specificities
3.1
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Update chemical activity to schema version 2.11
Detailed domain annotation
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