BGC0000340: echoside A biosynthetic gene cluster from Streptomyces sp. LZ35
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Location: 1 - 18,739 nt. (total: 18,739 nt).
This entry is originally from NCBI GenBank KJ156360.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
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Gene details
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General
Compounds
Genes
NRP
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0000340
Short description echoside A biosynthetic gene cluster from Streptomyces sp. LZ35
Status Minimal annotation: no
A minimal annotation only contains information on the BGC loci and one or more linked chemical product(s)

Completeness: Unknown
Whether the loci encodes everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRP
Loci NCBI GenBank: KJ156360.1
Compounds
  • echoside A
  • echoside B
  • echoside C
  • echoside D
  • echoside E
Species Streptomyces sp. LZ35 [taxonomy]
References
Chemical products information
echoside A
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C25H24O9
Chemical database entries
NPAtlas
echoside B
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C25H24O9
Chemical database entries
NPAtlas
echoside C
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C24H22O9
Chemical database entries
NPAtlas
echoside D
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C25H21N1O8S1
Chemical database entries
NPAtlas
echoside E
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C26H23N1O9S1
Chemical database entries
NPAtlas
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • AHN91915.1
  • echD
 201 - 977 (+) EchD
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  • AHN91916.1
 1208 - 1969 (-) ABC transporter
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  • AHN91917.1
 1966 - 2904 (-) ABC transporter permease
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  • AHN91918.1
 2950 - 3903 (-) ABC transporter substrate-binding protein
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  • AHN91919.1
 4417 - 5649 (+) malate dehydrogenase
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  • AHN91920.1
 5670 - 6758 (+) alcohol dehydrogenase
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  • AHN91921.1
 6927 - 7703 (-) antibiotic biosynthesis monooxygenase
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  • AHN91922.1
 7887 - 8981 (-) PadR family transcriptional regulator
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  • AHN91923.1
 8981 - 9838 (-) hypothetical protein
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  • AHN91924.1
  • echA
 10229 - 13132 (+) EchA
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  • AHN91925.1
  • echB
 13217 - 14140 (+) EchB
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  • AHN91926.1
  • echC
 14165 - 14575 (+) EchC
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  • AHN91927.1
 14670 - 15290 (-) nitroreductase
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  • AHN91928.1
 15408 - 16091 (+) TetR family transcriptional regulator
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  • AHN91929.1
 16114 - 16929 (+) SARP family transcriptional regulator
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  • AHN91930.1
 17357 - 18088 (+) short-chain dehydrogenase/reductase SDR
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  • AHN91931.1
 18159 - 18539 (+) MerR family transcriptional regulator
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NRP-specific information
Subclass N/A
Cyclic? no
NRP-synthases
Gene Modules
echA
Module ?
Specificity: phenylpyruvic acid
Evidence for specificity:
  • Structure-based inference
  • Knock-out studies
  • Mass spectrometry
Annotation changelog
MIBiG version Submitter Notes
1.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Submitted
2.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Migrated from v1.4
  • Updated compound(s) information (NPAtlas curation)
3.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Updated bioactivity data
  • Added NRP substrate specificities
3.1
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Update chemical activity to schema version 2.11
Detailed domain annotation
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