BGC0000340: echoside A biosynthetic gene cluster from Streptomyces sp. LZ35
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Location: 1 - 18,739 nt. (total: 18,739 nt).
This entry is originally from NCBI GenBank KJ156360.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
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General
Compounds
Genes
Biosynthesis
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0000340
Short description echoside A biosynthetic gene cluster from Streptomyces sp. LZ35
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: unknown
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRPS (Type I)
Loci
KJ156360.1
via
Compounds
  • echoside A
  • echoside B
  • echoside C
  • echoside D
  • echoside E
Species Streptomyces sp. LZ35 [taxonomy]
References
Chemical products information
echoside A Evidence:
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C25H24O9
Chemical database entries
NPAtlas
echoside B Evidence:
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C25H24O9
Chemical database entries
NPAtlas
echoside C Evidence:
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C24H22O9
Chemical database entries
NPAtlas
echoside D Evidence:
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C25H21N1O8S1
Chemical database entries
NPAtlas
echoside E Evidence:
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C26H23N1O9S1
Chemical database entries
NPAtlas
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • AHN91915.1
  • echD
 201 - 977 (+) EchD
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    • AHN91916.1
    		 1208 - 1969 (-) ABC transporter
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      • AHN91917.1
      		 1966 - 2904 (-) ABC transporter permease
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        • AHN91918.1
        		 2950 - 3903 (-) ABC transporter substrate-binding protein
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          • AHN91919.1
          		 4417 - 5649 (+) malate dehydrogenase
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            • AHN91920.1
            		 5670 - 6758 (+) alcohol dehydrogenase
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              • AHN91921.1
              		 6927 - 7703 (-) antibiotic biosynthesis monooxygenase
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                • AHN91922.1
                		 7887 - 8981 (-) PadR family transcriptional regulator
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                  • AHN91923.1
                  		 8981 - 9838 (-) hypothetical protein
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                    • AHN91924.1
                    • echA
                    		 10229 - 13132 (+) EchA
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                      • AHN91925.1
                      • echB
                      		 13217 - 14140 (+) EchB
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                        • AHN91926.1
                        • echC
                        		 14165 - 14575 (+) EchC
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                          • AHN91927.1
                          		 14670 - 15290 (-) nitroreductase
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                            • AHN91928.1
                            		 15408 - 16091 (+) TetR family transcriptional regulator
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                              • AHN91929.1
                              		 16114 - 16929 (+) SARP family transcriptional regulator
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                                • AHN91930.1
                                		 17357 - 18088 (+) short-chain dehydrogenase/reductase SDR
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                                  • AHN91931.1
                                  		 18159 - 18539 (+) MerR family transcriptional regulator
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                                    Biosynthesis information

                                    Biosynthetic modules

                                    Name
                                    Unk01
                                    Type
                                    nrps-type1
                                    Genes
                                    echA
                                    Substrates
                                    phenylpyruvic acid (evidence: Structure-based inference, Knock-out studies, Mass spectrometry)
                                    Integrated Monomers
                                    Domains
                                    adenylation
                                    Annotation changelog

                                    Entry version: 4

                                    Date
                                    Changes
                                    Submitters
                                    Reviewers
                                    2022-10-07
                                    Update chemical activity to schema version 2.11
                                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                    Entry version: 3

                                    Date
                                    Changes
                                    Submitters
                                    Reviewers
                                    2022-09-15
                                    Updated bioactivity data
                                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                    2022-09-15
                                    Added NRP substrate specificities
                                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                    Entry version: 2

                                    Date
                                    Changes
                                    Submitters
                                    Reviewers
                                    2019-10-16
                                    Migrated from v1.4
                                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                    2019-10-16
                                    Updated compound(s) information (NPAtlas curation)
                                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                    Entry version: 1

                                    Date
                                    Changes
                                    Submitters
                                    Reviewers
                                    2015-06-12
                                    Submitted
                                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                    Detailed domain annotation
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